344 results on '"Zorzi, C."'
Search Results
102. Deep brain stimulation of the internal part of pallidum in the surgical treatment of Dystonia,La neurostimolazione cerebrale profonda del nucleo pallido interno nel trattamento chirurgico della distonia
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Franzini, A., Carlo Efisio Marras, Tringali, G., Ferroli, P., Zorzi, C., Romito, L., and Broggi, G.
103. Effect of infused hypothalamic phospholipids on the maturation of foetal rabbit lungs
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Rubaltelli, F.F., primary, Saia, S.O., additional, Chiozza, M.Laura, additional, Zorzi, C., additional, Baroni, A., additional, Terribile, V., additional, Gonzato, P., additional, and Cantarutti, F., additional
- Published
- 1979
- Full Text
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104. NEURODEVELOPMENTAL OUTCOME IN PRETERM INFANTS WITH CEREBRAL INTRAVENTRICULAR HEMORRHAGE
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Dalla Barba, B, primary, Stefani, D, additional, Benini, F, additional, Zaramella, P, additional, Ruzza, P, additional, Melli, R, additional, Bricca, P, additional, Zorzi, C, additional, and Rubaltelli, F F, additional
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- 1987
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105. BRAIN ULTRASONOGRAPHY IN NEWBORNS AND INFANTS
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Saia, O S, primary, Zorzi, C, additional, Sambugaro, D, additional, Frate, E, additional, and Rubaltell, F F, additional
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- 1984
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106. Randomized, single center, observer-blind, parallel-group trial to evaluate the safety and effectiveness of HYADD®4-G a viscoelastic hydrogel, for the treatment of meniscus tear.
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Zorzi, C., Rigotti, S., Giordan, N., Madonna, V., Condello, V., Cortese, F., and Iacono, V.
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- 2014
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107. The contribution of neuropsychological and clinical-epidemiological variables in the prediction of treatment outcome in obsessive-compulsive disorder
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Cavedini, P., Ubbiali, A., Gorini, A., Zorzi, C., Bassi, T., Giordani, S., and D'Annucci, A.
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- 2002
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108. NEURODEVELOPMENTAL OUTCOME IN PRETERM INFANTS WITH CEREBRAL INTRAVENTRICULAR HEMORRHAGE
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Barba, B Dalla, Stefani, D, Benini, F, Zaramella, P, Ruzza, P, Melli, R, Bricca, P, Zorzi, C, and Rubaltelli, F F
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- 1987
109. Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year follow-up
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Simone, Natali, Daniele, Screpis, Michele, Romeo, Stefano, Magnanelli, Giuseppe, Rovere, Amarossi, Andrea, Lawrence, Camarda, Claudio, Zorzi, Natali S., Screpis D., Romeo M., Magnanelli S., Rovere G., Andrea A., Camarda L., and Zorzi C.
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Adipose-derived mesenchymal stem cells ,Hip osteoarthritis ,Orthopedics and Sports Medicine ,Surgery ,Autologous micro-fragmented adipose tissue - Abstract
Background Recently, increased attention on regenerative medicine and biological injective treatments have been proposed to restore native cartilage. Micro-fragmented adipose tissue (MFAT) has been studied for its anti-inflammatory, paracrine, and immunomodulatory effects. The long-term effects of MFAT are still poorly understood: the aim of the present study is to demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes. Methods Seventy-one consecutive patients affected by early hip osteoarthritis underwent an ultrasound-guided hip injection of autologous MFAT between June 2017 and December 2018. Patients were divided into four groups according to the Oxford Hip Score. All patients received 4 mL of autologous micro-fragmented adipose tissue under an ultrasound guide. A clinical evaluation was done between 29 and 41 months after the initial treatment. During this follow-up period, we recorded any new treatment the patients had done, whether that be injection or arthroplasty surgery. Results The study included 55 patients. Out of 55 patients, 28 saw benefits and were in no need of further treatment. Moreover, the score between the beginning and control increased by 6.9 points. Ten patients underwent a new articular injection: the mean time between the two injections was 635.7 ± 180 days. Seventeen patients underwent total hip replacement: the mean period between the autologous MFAT injection and the surgery was 495 days. Conclusion This study found that intra-articular injections with autologous MFAT achieve beneficial clinical results in patients affected by early to moderate hip osteoarthritis, with an OHS between 48 and 30. Furthermore, these subjects are the ideal patients for whom this treatment obtains good clinical results.
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- 2022
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110. Metal PVD honey-combs coated with TIO2 and Al2O3 via PECVD suitable for sensoring applications.
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Cavallin, T., Visentin, F., Peruzzo, V., Desideri, D., Maschio, A., El Habra, N., Sartori, A., De Zorzi, C., Gerbasi, R., Favaro, M., and Rossetto, G.
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PHYSICAL vapor deposition , *HONEYCOMB structures , *TITANIUM oxides , *PLASMA-enhanced chemical vapor deposition , *ENERGY dispersive X-ray spectroscopy , *METALLIC films - Abstract
Abstract: Economical and self-assembling polystyrene ‘Breath Figures’ method has been used to obtain a large polymeric 3D honey-comb structure substrate successively coated with metallic ductile films with thickness of few hundreds of nanometers deposited via DC magnetron sputtering. Finally, the obtained metallic 3D honey-comb structures have been functionalized by ceramic coatings such as titanium dioxide (TiO2) and aluminum oxide (Al2O3) via radio frequency-plasma enhanced chemical vapor deposition (RF-PECVD) having the role of the active parts. The films have been investigated by scanning electron microscopy (SEM) and optical microscopy to define their morphology, while energy dispersive X-ray spectroscopy (EDS) measurements were carried out to determine their elemental composition. The electrical characterization of the metallic films has been performed by using a four-point probe method. The sheet resistance RS of the films has been derived and the results discussed taking into account its dependence on the effective superficial length due to Breath Figures morphological benefit. [Copyright &y& Elsevier]
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- 2013
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111. Validation of the Somnotouch-NIBP noninvasive continuous blood pressure monitor according to the European Society of Hypertension International Protocol revision 2010
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Juan E. Ochoa Munera, Gianfranco Parati, Cristina Zorzi, Valentina Giuli, Camilla Torlasco, Grzegorz Bilo, Bilo, G, Zorzi, C, OCHOA MUNERA, J, Torlasco, C, Giuli, V, and Parati, G
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Male ,medicine.medical_specialty ,Systole ,Diastole ,Assessment and Diagnosis ,Pulse Wave Analysis ,continuous blood pressure monitoring ,Assessment and Diagnosi ,Electrocardiography ,Clinical Protocols ,Heart Rate ,pulse transit time ,Internal medicine ,Heart rate ,medicine ,Internal Medicine ,Plethysmograph ,Humans ,Aged ,Protocol (science) ,Observer Variation ,validation ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,Anthropometry ,business.industry ,Disease Management ,General Medicine ,Equipment Design ,Blood Pressure Monitoring, Ambulatory ,Middle Aged ,Blood Pressure Monitors ,Surgery ,Plethysmography ,Blood pressure ,Hypertension ,Cardiology ,Arm ,Female ,business ,Cardiology and Cardiovascular Medicine ,Devices and Technology - Abstract
Objective The present study aimed to evaluate the accuracy of the Somnotouch-NIBP noninvasive continuous blood pressure monitor according to the European Society of Hypertension International Protocol revision 2010. Materials and methods Systolic and diastolic blood pressures were sequentially measured in 33 adults (11 women, mean age 63.5±11.9 years) using a mercury sphygmomanometer (two observers) and the Somnotouch-NIBP device (one supervisor). A total of 99 pairs of comparisons were obtained from 33 participants for judgments in two parts with three grading phases. Results All the validation requirements were fulfilled. The Somnotouch-NIBP device fulfilled the requirements of the part 1 of the validation study. The number of absolute differences between device and observers within 5, 10, and 15 mmHg was 75/99, 90/99, and 96/99, respectively, for systolic blood pressure and 90/99, 99/99, and 99/99, respectively, for diastolic blood pressure. The device also fulfilled the criteria in part 2 of the validation study. Twenty-seven and 31 participants had at least two of the three device-observers differences less than or equal to 5 mmHg for systolic and diastolic blood pressure, respectively. All three device-observer differences were greater than 5 mmHg in two participants for systolic and in one participant for diastolic blood pressure. Conclusion The Somnotouch-NIBP noninvasive continuous blood pressure monitor has passed the requirements of the International Protocol revision 2010, and hence can be recommended for blood pressure monitoring in adults, at least under conditions corresponding to those investigated in our study.
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- 2015
112. The problems in the revision of unicompartimental prosthesis with total knee arthroplasty
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ROSA, DONATO, RUSSO, ARCANGELO, Zorzi Claudio, Madonna, Auletta, Nicola, Crispino, Vincenzo, Rosa D, Zorzi C, Madonna V, Russo A, Auletta N, Crispino V, Rosa, Donato, Zorzi Claudio, Madonna, Russo, Arcangelo, Auletta, Nicola, and Crispino, Vincenzo
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- 2013
113. Ricostruzione con STG a Singolo Fascio – Tecnica Transtibiale, Transportale, Over The Top
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ZAFFAGNINI, STEFANO, NITRI, MARCO, BONANZINGA, TOMMASO, MARCACCI, MAURILIO, Adravanti P, Denti M, Mazzola C, Randelli P, Zorzi C., Zaffagnini, S., Nitri, M., Bonanzinga, T., and Marcacci, M.
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Over the top ,anteriore ,ACL ,Crociato ,ricostruzione - Abstract
No abstact
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- 2012
114. Tecniche chirurgiche con scaffold
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KON, ELIZAVETA, FILARDO, GIUSEPPE, MARCACCI, MAURILIO, F. Perdisa, A. Di Martino, S. Patella, B. Di Matteo, M. L. Merli, L. De Pasqual, Randelli P, Mazzola C, Adravanti P, Zorzi C, Denti M, E. Kon, G. Filardo, F. Perdisa, A. Di Martino, S. Patella, B. Di Matteo, M.L. Merli, L. De Pasqual, and M. Marcacci.
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Scaffold - Abstract
La maggior attenzione oggi rivolta all’attività fisica in ogni fascia d’età e le crescenti aspettative di recupero dei pazienti rendono le patologie a carico della cartilagine articolare un problema più che mai attuale. Sfortunatamente l’isolamento del tessuto cartilagineo dalla circolazione sistemica e la sua mancanza di apporto vascolo-nervoso ne determinano la scarsa capacità rigenerativa (1,2), che rende difficile il trattamento di questi difetti i quali, anche quando isolati, rappresentano un importante fattore di rischio di ulteriore danno articolare. Nel tempo sono state proposte molte tecniche per il trattamento cartilagineo, più o meno efficaci (3,4,5,6). Sono anzitutto state sviluppate tecniche che mirano a reclutare cellule staminali dal midollo quali potenziali precursori della cartilagine (7). Trattamenti di questo tipo come abrasione, drilling o microfratture, producono però soprattutto un tessuto di riparazione fibroso a base prevalentemente di collagene tipo I, fibrociti e matrice non organizzata (8), privo dunque delle appropriate caratteristiche biomeccaniche e viscoelastiche che ne consentirebbero la durata a lungo termine (9). Un altro tipo di approccio alla ricostruzione cartilaginea, l’innesto osteocondrale autologo (osteochondral autologous allograft: OAT) proposto da Hangody (10), si è rilevato utile nel ridurre il dolore e migliorare la funzione, ma limitatamente a lesioni di superficie compresa tra 1 e 2,5 cm di dimensione (11). Quest’ultima è inoltre una procedura tecnicamente impegnativa in cui la sede e la taglia del prelievo giocano un ruolo fondamentale. La completa copertura del difetto, la stabilità meccanica dei plugs e la possibilità di ricostruire una buona superficie cartilaginea sono obiettivi difficili da ottenere. Vi è infine un’importante limitazione nella disponibilità di grafts che limita molto l’impiego di questa tecnica. Già da diversi anni più ambiziose procedure rigenerative stanno emergendo come potenziali alternative a queste tecniche, con l’obiettivo di ricreare un tessuto simil-ialino capace di ripristinare una valida superficie articolare (12,13,14). La prima procedura di questo genere ad essere sviluppata è stata l’innesto di condrociti autologhi (ACI), successivamente etichettato come “di prima generazione”. La tecnica consiste nel prelevare condrociti da una zona di non carico dell’articolazione interessata ed innestarli a livello del difetto cartilagineo da trattare in seguito a 4 settimane di coltura cellulare (13). Per mantenere l’innesto in sede, trattandosi di una soluzione cellulare, è prevista la sutura di un lembo periostale prelevato dalla tibia omolaterale a coprire il difetto precedentemente preparato. A dispetto degli incoraggianti risultati clinici e della superficie simil-ialina ottenuta (12,13,14,15), l’originale tecnica ACI doveva far fronte a numerose limitazioni dovute a complessità e morbidità della procedura chirurgica, poiché era necessario un ampio accesso artrotomico, accrescendo il rischio di rigidità e fibrosi articolare (16,17,18). Altri punti critici si sono evidenziati nel mantenere il fenotipo condrocitico durante la coltura cellulare in monostrato. I condrociti in colture cellulari bidimensionali alterano infatti il loro fenotipo e si de-differenziano in fibroblasti, perdendo la loro capacità di produrre collagene tipo II o proteoglicani (12), e non è ancora chiaro se le cellule ritornino ad esprimere il loro fenotipo dopo il trapianto. E’ poi dibattuto se i condrociti in sospensione cellulare liquida si distribuiscano in maniera uniforme all’interno dello spazio tridimensionale del difetto. Infine sono state rilevate complicanze di non secondaria importanza dovute alla possibile ipertrofia del lembo periostale impiegato. Tutti questi motivi hanno spinto principalmente la ricerca allo sviluppo di tecniche alternative, avvalendosi delle nuove tecniche di bioingegneria tissutale, capaci di ovviare a queste problematiche.
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- 2012
115. Search for same-sign top-quark production and fourth-generation down-type quarks in pp collisions at √s = 7 TeV with the ATLAS detector
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G. AAD, E. ABAT, B. ABBOTT, J. ABDALLAH, A. A. ABDELALIM, A. ABDESSELAM, O. ABDINOV, B. ABI, M. ABOLINS, H. ABRAMOWICZ, H. ABREU, E. ACERBI, B. S. ACHARYA, M. ACKERS, D. L. ADAMS, T. N. ADDY, J. ADELMAN, M. ADERHOLZ, C. ADORISIO, P. ADRAGNA, T. ADYE, S. AEFSKY, J. A. AGUILAR SAAVEDRA, M. AHARROUCHE, S. P. AHLEN, F. AHLES, A. AHMAD, H. AHMED, M. AHSAN, G. AIELLI, T. AKDOGAN, P. F. AKESSON, T. P. A. AKESSON, G. AKIMOTO, A. V. AKIMOV, A. AKTAS, M. S. ALAM, M. A. ALAM, J. ALBERT, S. ALBRAND, M. ALEKSA, I. N. ALEKSANDROV, M. ALEPPO, F. ALESSANDRIA, C. ALEXA, G. ALEXANDER, G. ALEXANDRE, T. ALEXOPOULOS, M. ALHROOB, M. ALIEV, G. ALIMONTI, J. ALISON, M. ALIYEV, P. P. ALLPORT, S. E. ALLWOOD SPIERS, J. ALMOND, A. ALOISIO, R. ALON, A. ALONSO, J. ALONSO, M. G. ALVIGGI, K. AMAKO, P. AMARAL, G. AMBROSINI, G. AMBROSIO, C. AMELUNG, V. V. AMMOSOV, A. AMORIM, G. AMOROS, N. AMRAM, C. ANASTOPOULOS, T. ANDEEN, C. F. ANDERS, K. J. ANDERSON, A. ANDREAZZA, V. ANDREI, M. L. ANDRIEUX, X. S. ANDUAGA, A. ANGERAMI, F. ANGHINOLFI, N. ANJOS, A. ANNOVI, A. ANTONAKI, M. ANTONELLI, S. ANTONELLI, J. ANTOS, B. ANTUNOVIC, F. ANULLI, S. AOUN, G. ARABIDZE, I. ARACENA, Y. ARAI, A. T. H. ARCE, J. P. ARCHAMBAULT, S. ARFAOUI, J. F. ARGUIN, T. ARGYROPOULOS, E. ARIK, M. ARIK, A. J. ARMBRUSTER, K. E. ARMS, S. R. ARMSTRONG, O. ARNAEZ, C. ARNAULT, A. ARTAMONOV, D. ARUTINOV, M. ASAI, S. ASAI, R. ASFANDIYAROV, S. ASK, B. ASMAN, D. ASNER, L. ASQUITH, K. ASSAMAGAN, A. ASTBURY, A. ASTVATSATOUROV, B. ATHAR, G. ATOIAN, B. AUBERT, B. AUERBACH, E. AUGE, K. AUGSTEN, M. AUROUSSEAU, N. AUSTIN, G. AVOLIO, R. AVRAMIDOU, D. AXEN, C. AY, G. AZUELOS, Y. AZUMA, M. A. BAAK, G. BACCAGLIONI, C. BACCI, A. M. BACH, H. BACHACOU, K. BACHAS, G. BACHY, M. BACKES, E. BADESCU, P. BAGNAIA, Y. BAI, D. C. BAILEY, T. BAIN, J. T. BAINES, O. K. BAKER, M. D. BAKER, S. BAKER, F. BALTASAR DOS SANTOS PEDROSA, E. BANAS, P. BANERJEE, S. BANERJEE, D. BANFI, A. BANGERT, V. BANSAL, S. P. BARANOV, S. BARANOV, A. BARASHKOU, T. BARBER, E. L. BARBERIO, D. BARBERIS, M. BARBERO, D. Y. BARDIN, T. BARILLARI, M. BARISONZI, T. BARKLOW, N. BARLOW, B. M. BARNETT, R. M. BARNETT, A. BARONCELLI, M. BARONE, A. J. BARR, F. BARREIRO, J. BARREIRO GUIMARAES DA COSTA, P. BARRILLON, V. BARTHELD, H. BARTKO, R. BARTOLDUS, D. BARTSCH, R. L. BATES, S. BATHE, L. BATKOVA, J. R. BATLEY, A. BATTAGLIA, M. BATTISTIN, G. BATTISTONI, F. BAUER, H. S. BAWA, M. BAZALOVA, B. BEARE, T. BEAU, P. H. BEAUCHEMIN, R. BECCHERLE, N. BECERICI, P. BECHTLE, G. A. BECK, H. P. BECK, M. BECKINGHAM, K. H. BECKS, A. J. BEDDALL, A. BEDDALL, V. A. BEDNYAKOV, C. BEE, M. BEGEL, S. BEHAR HARPAZ, P. K. BEHERA, M. BEIMFORDE, G. A. N. BELANGER, C. BELANGER CHAMPAGNE, B. BELHORMA, P. J. BELL, W. H. BELL, G. BELLA, L. BELLAGAMBA, F. BELLINA, G. BELLOMO, M. BELLOMO, A. BELLONI, K. BELOTSKIY, O. BELTRAMELLO, A. BELYMAM, S. BEN AMI, O. BENARY, D. BENCHEKROUN, C. BENCHOUK, M. BENDEL, B. H. BENEDICT, N. BENEKOS, Y. BENHAMMOU, G. P. BENINCASA, D. P. BENJAMIN, M. BENOIT, J. R. BENSINGER, K. BENSLAMA, S. BENTVELSEN, M. BERETTA, D. BERGE, E. BERGEAAS KUUTMANN, N. BERGER, F. BERGHAUS, E. BERGLUND, J. BERINGER, K. BERNARDET, P. BERNAT, R. BERNHARD, C. BERNIUS, T. BERRY, F. BERTINELLI, S. BERTOLUCCI, M. I. BESANA, N. BESSON, S. BETHKE, R. M. BIANCHI, M. BIANCO, O. BIEBEL, M. BIERI, J. BIESIADA, M. BIGLIETTI, H. BILOKON, M. BINDER, S. BINET, A. BINGUL, C. BINI, C. BISCARAT, R. BISCHOF, U. BITENC, K. M. BLACK, R. E. BLAIR, O. BLANCH, J. B. BLANCHARD, G. BLANCHOT, C. BLOCKER, J. BLOCKI, A. BLONDEL, W. BLUM, U. BLUMENSCHEIN, C. BOARETTO, G. J. BOBBINK, A. BOCCI, D. BOCIAN, R. BOCK, M. BOEHLER, M. BOEHM, J. BOEK, N. BOELAERT, S. BOSER, J. A. BOGAERTS, A. BOGOUCH, C. BOHM, J. BOHM, V. BOISVERT, T. BOLD, V. BOLDEA, A. BOLDYREV, V. G. BONDARENKO, M. BONDIOLI, R. BONINO, M. BOONEKAMP, G. BOORMAN, M. BOOSTEN, C. N. BOOTH, P. S. L. BOOTH, P. BOOTH, J. R. A. BOOTH, S. BORDONI, C. BORER, K. BORER, A. BORISOV, G. BORISSOV, I. BORJANOVIC, S. BORRONI, K. BOS, D. BOSCHERINI, M. BOSMAN, H. BOTERENBROOD, D. BOTTERILL, J. BOUCHAMI, J. BOUDREAU, E. V. BOUHOVA THACKER, C. BOULAHOUACHE, C. BOURDARIOS, A. BOVEIA, J. BOYD, B. H. BOYER, I. R. BOYKO, N. I. BOZHKO, I. BOZOVIC JELISAVCIC, S. BRACCINI, J. BRACINIK, A. BRAEM, E. BRAMBILLA, P. BRANCHINI, G. W. BRANDENBURG, A. BRANDT, G. BRANDT, O. BRANDT, U. BRATZLER, B. BRAU, J. E. BRAU, H. M. BRAUN, S. BRAVO, B. BRELIER, J. BREMER, R. BRENNER, S. BRESSLER, D. BRETON, N. D. BRETT, P. G. BRIGHT THOMAS, D. BRITTON, F. M. BROCHU, I. BROCK, R. BROCK, T. J. BRODBECK, E. BRODET, F. BROGGI, C. BROMBERG, G. BROOIJMANS, W. K. BROOKS, G. BROWN, E. BRUBAKER, P. A. BRUCKMAN DE RENSTROM, D. BRUNCKO, R. BRUNELIERE, S. BRUNET, A. BRUNI, G. BRUNI, M. BRUSCHI, T. BUANES, F. BUCCI, J. BUCHANAN, N. J. BUCHANAN, P. BUCHHOLZ, A. G. BUCKLEY, I. A. BUDAGOV, B. BUDICK, V. BUSCHER, L. BUGGE, D. BUIRA CLARK, E. J. BUIS, F. BUJOR, O. BULEKOV, M. BUNSE, T. BURAN, H. BURCKHART, S. BURDIN, T. BURGESS, S. BURKE, E. BUSATO, P. BUSSEY, C. P. BUSZELLO, F. BUTIN, B. BUTLER, J. M. BUTLER, C. M. BUTTAR, J. M. BUTTERWORTH, T. BYATT, J. CABALLERO, S. CABRERA URBAN, M. CACCIA, O. CAKIR, P. CALAFIURA, G. CALDERINI, P. CALFAYAN, R. CALKINS, L. P. CALOBA, R. CALOI, D. CALVET, A. CAMARD, P. CAMARRI, M. CAMBIAGHI, D. CAMERON, J. CAMMIN, S. CAMPANA, M. CAMPANELLI, V. CANALE, F. CANELLI, A. CANEPA, J. CANTERO, L. CAPASSO, M. D. M. CAPEANS GARRIDO, I. CAPRINI, M. CAPRINI, M. CAPRIO, M. CAPUA, R. CAPUTO, C. CARAMARCU, R. CARDARELLI, L. CARDIEL SAS, T. CARLI, G. CARLINO, L. CARMINATI, B. CARON, S. CARON, C. CARPENTIERI, G. D. CARRILLO MONTOYA, S. CARRON MONTERO, A. A. CARTER, J. R. CARTER, J. CARVALHO, D. CASADEI, M. P. CASADO, M. CASCELLA, C. CASO, A. M. CASTANEDA HERNADEZ, E. CASTANEDA MIRANDA, V. CASTILLO GIMENEZ, N. F. CASTRO, F. CASTROVILLARI, G. CATALDI, F. CATANEO, A. CATINACCIO, J. R. CATMORE, A. CATTAI, G. CATTANI, S. CAUGHRON, D. CAUZ, A. CAVALLARI, P. CAVALLERI, D. CAVALLI, M. CAVALLI SFORZA, V. CAVASINNI, A. CAZZATO, F. CERADINI, C. CERNA, A. S. CERQUEIRA, A. CERRI, L. CERRITO, F. CERUTTI, M. CERVETTO, S. A. CETIN, F. CEVENINI, A. CHAFAQ, D. CHAKRABORTY, K. CHAN, J. D. CHAPMAN, J. W. CHAPMAN, E. CHAREYRE, D. G. CHARLTON, S. CHARRON, S. CHATTERJII, V. CHAVDA, S. CHEATHAM, S. CHEKANOV, S. V. CHEKULAEV, G. A. CHELKOV, H. CHEN, L. CHEN, S. CHEN, T. CHEN, X. CHEN, S. CHENG, A. CHEPLAKOV, V. F. CHEPURNOV, R. CHERKAOUI EL MOURSLI, V. TCHERNIATINE, D. CHESNEANU, E. CHEU, S. L. CHEUNG, L. CHEVALIER, F. CHEVALLIER, V. CHIARELLA, G. CHIEFARI, L. CHIKOVANI, J. T. CHILDERS, A. CHILINGAROV, G. CHIODINI, V. CHIZHOV, G. CHOUDALAKIS, S. CHOURIDOU, T. CHRISTIANSEN, I. A. CHRISTIDI, A. CHRISTOV, D. CHROMEK BURCKHART, M. L. CHU, J. CHUDOBA, G. CIAPETTI, E. CICALINI, A. K. CIFTCI, R. CIFTCI, D. CINCA, V. CINDRO, M. D. CIOBOTARU, C. CIOCCA, A. CIOCIO, M. CIRILLI, M. CITTERIO, A. CLARK, P. J. CLARK, W. CLELAND, J. C. CLEMENS, B. CLEMENT, C. CLEMENT, D. CLEMENTS, R. W. CLIFFT, Y. COADOU, M. COBAL, A. COCCARO, J. COCHRAN, R. COCO, P. 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VAN DER GRAAF, E. VAN DER KRAAIJ, E. VAN DER POEL, D. VAN DER STER, B. VAN EIJK, N. VAN ELDIK, P. VAN GEMMEREN, Z. VAN KESTEREN, I. VAN VULPEN, W. VANDELLI, G. VANDONI, A. VANIACHINE, P. VANKOV, F. VANNUCCI, F. VARELA RODRIGUEZ, R. VARI, E. W. VARNES, D. VAROUCHAS, A. VARTAPETIAN, K. E. VARVELL, L. VASILYEVA, V. I. VASSILAKOPOULOS, F. VAZEILLE, G. VEGNI, J. J. VEILLET, C. VELLIDIS, F. VELOSO, R. VENESS, S. VENEZIANO, A. VENTURA, D. VENTURA, S. VENTURA, M. VENTURI, N. VENTURI, V. VERCESI, M. VERDUCCI, W. VERKERKE, J. C. VERMEULEN, L. VERTOGARDOV, M. C. VETTERLI, I. VICHOU, T. VICKEY, G. H. A. VIEHHAUSER, E. G. VILLANI, M. VILLAPLANA PEREZ, E. VILUCCHI, P. VINCENT, M. G. VINCTER, E. VINEK, V. B. VINOGRADOV, M. VIRCHAUX, S. VIRET, J. VIRZI, O. VITELLS, I. VIVARELLI, F. VIVES VAQUE, S. VLACHOS, M. VLASAK, N. VLASOV, A. VOGEL, H. VOGT, P. VOKAC, C. F. VOLLMER, M. VOLPI, G. VOLPINI, H. VON DER SCHMITT, J. VON LOEBEN, H. VON RADZIEWSKI, E. VON TOERNE, V. VOROBEL, A. P. VOROBIEV, V. 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WIELERS, P. WIENEMANN, M. WIESMANN, C. WIGLESWORTH, L. A. M. WIIK, A. WILDAUER, M. A. WILDT, I. WILHELM, H. G. WILKENS, E. WILLIAMS, H. H. WILLIAMS, W. WILLIS, S. WILLOCQ, J. A. WILSON, M. G. WILSON, A. WILSON, I. WINGERTER SEEZ, F. WINKLMEIER, M. WITTGEN, E. WOEHRLING, M. W. WOLTER, H. WOLTERS, B. K. WOSIEK, J. WOTSCHACK, M. J. WOUDSTRA, K. WRAIGHT, C. WRIGHT, D. WRIGHT, B. WRONA, S. L. WU, X. WU, J. WUESTENFELD, E. WULF, R. WUNSTORF, B. M. WYNNE, L. XAPLANTERIS, S. XELLA, S. XIE, Y. XIE, D. XU, G. XU, N. XU, M. YAMADA, A. YAMAMOTO, K. YAMAMOTO, S. YAMAMOTO, T. YAMAMURA, J. YAMAOKA, T. YAMAZAKI, Y. YAMAZAKI, Z. YAN, H. YANG, S. YANG, U. K. YANG, Y. YANG, Z. YANG, W. M. YAO, Y. YAO, K. YARRADODDI, Y. YASU, J. YE, S. YE, M. YILMAZ, R. YOOSOOFMIYA, K. YORITA, H. YOSHIDA, R. YOSHIDA, C. YOUNG, S. P. YOUSSEF, D. YU, J. YU, J. YUAN, L. YUAN, A. YURKEWICZ, V. G. ZAETS, R. ZAIDAN, A. M. ZAITSEV, Z. ZAJACOVA, Y.O. K. ZALITE, V. ZAMBRANO, L. ZANELLO, P. ZARZHITSKY, A. ZAYTSEV, M. ZDRAZIL, C. ZEITNITZ, M. ZELLER, P. F. ZEMA, A. ZEMLA, C. ZENDLER, A. V. ZENIN, O. ZENIN, T. ZENIS, Z. ZENONOS, S. ZENZ, D. ZERWAS, G. ZEVI DELLA PORTA, Z. ZHAN, H. ZHANG, J. ZHANG, Q. ZHANG, X. ZHANG, L. ZHAO, T. ZHAO, Z. ZHAO, A. ZHEMCHUGOV, S. ZHENG, J. ZHONG, B. ZHOU, N. ZHOU, Y. ZHOU, C. G. ZHU, H. ZHU, Y. ZHU, X. ZHUANG, V. ZHURAVLOV, B. ZILKA, R. ZIMMERMANN, S. ZIMMERMANN, M. ZIOLKOWSKI, R. ZITOUN, L. ZIVKOVIC, V. V. ZMOUCHKO, G. ZOBERNIG, Y. ZOLNIEROWSKI, A. ZSENEI, M. ZUR NEDDEN, V. ZUTSHI, BERTIN, ANTONIO, BINDI, MARCELLO, CAFORIO, DAVIDE, DE CASTRO, STEFANO, DI SIPIO, RICCARDO, FABBRI, LAURA, FRANCHINI, MATTEO, MASSA, IGNAZIO GIACOMO, MENGARELLI, ALBERTO, MONZANI, SIMONE, PICCININI, MAURIZIO, RINALDI, LORENZO, SBARRA, CARLA, SBRIZZI, ANTONIO, SEMPRINI CESARI, NICOLA, VALENTINETTI, SARA, VILLA, MAURO, ZOCCOLI, ANTONIO, UAM. Departamento de Física Teórica, Abdelalim Aly, Ahmed Aly, Alexandre, Gauthier, Backes, Moritz, Barone, Gaetano, Bell, Paul, Bell, William, Benhar Noccioli, Eleonora, Blondel, Alain, Bucci, Francesca, Clark, Allan Geoffrey, Dao, Valerio, Doglioni, Caterina, Ferrere, Didier, Gadomski, Szymon, Gonzalez Sevilla, Sergio, Goulette, Marc, Iacobucci, Giuseppe, La Rosa, Alessandro, Leger, Annie, Lister, Alison, Martin Dit Latour, Bertrand, Mermod, Philippe, Mora Herrera, Maria Clemencia Rosario, Nektarijevic, Snezana, Nikolics, Katalin, Pasztor, Arpad, Picazio, Attilio, Pohl, Martin, Rosbach, Kilian, Rosselet, Laurent, Wu, Xin, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire, Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Aad, G, Abbott, B, Abdallah, J, Khalek, Sa, Abdelalim, Aa, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abouzeid, O, Abramowicz, H, Abreu, H, Acerbi, E, Aeharya, B, Adamezyk, L, Aams, Dl, Addy, Tn, Adelman, J, Aderhoz, M, Adomeit, S, Adragna, P, Adye, T, Aefsky, S, Aguilar Saavedra, Ja, Aharrouche, M, Ahlen, Sp, Ahles, F, Ahmad, A, Ahsan, M, Aielli, G, Akdogan, T, Akesson, Tpa, Akimoto, G, Akimov, Av, Akiyama, A, Alam, M, Alam, Ma, Albert, J, Albrand, S, Aleksa, M, Aleksandrov, In, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Aliyev, M, Allbrooke, Bmm, Allport, Pp, Allwood Spiers, Se, Almond, J, Aloisio, A, Alon, R, Alonso, A, Gonzalez, Ba, Alviggi, Mg, Amako, K, Amaral, P, Amelung, C, Ammosov, Vv, Amorim, A, Amoros, G, Amram, N, Anastopoulos, C, Aneu, L, Andari, N, Andeen, T, Anders, Cf, Anders, G, Anderson, Kj, Andreazza, A, Andrei, V, Andrieux, Ml, Anduaga, X, Angerami, A, Anghinolfi, F, Anisenkov, A, Anjos, N, Annovi, A, Antonaki, A, Antonelli, M, Antonov, A, Antos, J, Anulli, F, Aoun, S, Bella, La, Apolle, R, Arabidze, G, Aracena, I, Arai, Y, Arce, Ath, Arfaoui, S, Arguin, Jf, Arik, E, Arik, M, Armbruster, Aj, Arnaez, O, Arnal, V, Arnault, C, Artamonov, A, Artoni, G, Arutinov, D, Asai, S, Asfandiyarov, R, Ask, S, Asman, B, Asquith, L, Assamagan, K, Astbury, A, Astvatsatourov, A, Aubert, B, Auge, E, Augsten, K, Aurousseau, M, Avolio, G, Avramidou, R, Axen, D, Ay, C, Azuelos, G, Azuma, Y, Baak, Ma, Baccaglioni, G, Bacci, C, Bach, Am, Bachacou, H, Bachas, K, Backes, M, Backhaus, M, Badescu, E, Bagnaia, P, Bahinipati, S, Bai, Y, Bailey, Dc, Bain, T, Baines, Jt, Baker, Ok, Baker, Md, Baker, S, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Bansil, H, Barak, L, Baranov, Sp, Barashkou, A, Galtieri, Ab, Barber, T, Barberio, El, 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Zajacova, Z, Zanello, L, Zavtsev, A, Zeitnitz, C, Zeller, A, Zeman, M, Zemla, A, Zendler, C, Zenin, O, Zenis, T, Zinonos, Z, Zenz, S, Zerwas, D, della Porta, Gz, Zhan, Z, Zhang, D, Zhang, H, Zhang, J, Zhang, X, Zhang, Z, Zhao, L, Zhao, T, Zhao, Z, Zhemchugov, A, Zheng, S, Zhong, J, Zhou, B, Zhou, N, Zhou, Y, Zu, Cg, Zhu, H, Zhu, J, Zhu, Y, Zhuang, X, Zhuravlov, V, Zieminska, D, Zimmermann, R, Zimmermann, S, Ziolkowski, M, Zitoun, R, Zivkovic, L, Zmouchko, Vv, Zobernig, G, Zoccoli, A, Zolnierwski, Y, Zsenei, A, zur Nedden, M, Zutshi, V, Zwalinki, L., Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 3056, ATLAS (IHEF, IoP, FNWI), Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Cevenini, F., Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Patricelli, Sergio, Conventi, F., DELLA PIETRA, Massimo, Giordano, Raffaele, Musto, E., Rossi, E., Sanchez, A., Carlino, G., de Asmundis, R., Doria, A., Izzo, V., Sekhniaidze, G., Doğuş Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, TR3959, Çetin, Serkant Ali, Aad, G., Bianco, Michele, Chiodini, G., Gorini, Edoardo, Primavera, Margherita, Spagnolo, Stefania Antonia, Ventura, Andrea, G. 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VENTURA, S. VENTURA, M. VENTURI, N. VENTURI, V. VERCESI, M. VERDUCCI, W. VERKERKE, J.C. VERMEULEN, L. VERTOGARDOV, M.C. VETTERLI, I. VICHOU, T. VICKEY, G.H.A. VIEHHAUSER, M. VILLA, E.G. VILLANI, M. VILLAPLANA PEREZ, E. VILUCCHI, P. VINCENT, M.G. VINCTER, E. VINEK, V.B. VINOGRADOV, M. VIRCHAUX, S. VIRET, J. VIRZI, O. VITELLS, I. VIVARELLI, F. VIVES VAQUE, S. VLACHOS, M. VLASAK, N. VLASOV, A. VOGEL, H. VOGT, P. VOKAC, C.F. VOLLMER, M. VOLPI, G. VOLPINI, H. VON DER SCHMITT, J. VON LOEBEN, H. VON RADZIEWSKI, E. VON TOERNE, V. VOROBEL, A.P. VOROBIEV, V. VORWERK, M. VOS, K.C. VOSS, R. VOSS, T.T. VOSS, J.H. VOSSEBELD, A.S. VOVENKO, N. VRANJES, M. VRANJES MILOSAVLJEVIC, V. VRBA, M. VREESWIJK, T. VU ANH, B. VUARIDEL, D. VUDRAGOVIC, R. VUILLERMET, I. VUKOTIC, A. WAANANEN, P. WAGNER, H. WAHLEN, J. WALBERSLOH, J. WALDER, R. WALKER, W. WALKOWIAK, R. WALL, S. WALSH, C. WANG, H. WANG, J. WANG, J.C. WANG, M.W. WANG, S.M. WANG, F. WAPPLER, A. WARBURTON, C.P. WARD, M. WARSINSKY, R. WASTIE, P.M. 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XELLA, S. XIE, Y. XIE, D. XU, G. XU, N. XU, M. YAMADA, A. YAMAMOTO, K. YAMAMOTO, S. YAMAMOTO, T. YAMAMURA, J. YAMAOKA, T. YAMAZAKI, Y. YAMAZAKI, Z. YAN, H. YANG, S. YANG, U.K. YANG, Y. YANG, Z. YANG, W.-M. YAO, Y. YAO, K. YARRADODDI, Y. YASU, J. YE, S. YE, M. YILMAZ, R. YOOSOOFMIYA, K. YORITA, H. YOSHIDA, R. YOSHIDA, C. YOUNG, S.P. YOUSSEF, D. YU, J. YU, J. YUAN, L. YUAN, A. YURKEWICZ, V.G. ZAETS, R. ZAIDAN, A.M. ZAITSEV, Z. ZAJACOVA, YO.K. ZALITE, V. ZAMBRANO, L. ZANELLO, P. ZARZHITSKY, A. ZAYTSEV, M. ZDRAZIL, C. ZEITNITZ, M. ZELLER, P.F. ZEMA, A. ZEMLA, C. ZENDLER, A.V. ZENIN, O. ZENIN, T. ZENIS, Z. ZENONOS, S. ZENZ, D. ZERWAS, G. ZEVI DELLA PORTA, Z. ZHAN, H. ZHANG, J. ZHANG, Q. ZHANG, X. ZHANG, L. ZHAO, T. ZHAO, Z. ZHAO, A. ZHEMCHUGOV, S. ZHENG, J. ZHONG, B. ZHOU, N. ZHOU, Y. ZHOU, C.G. ZHU, H. ZHU, Y. ZHU, X. ZHUANG, V. ZHURAVLOV, B. ZILKA, R. ZIMMERMANN, S. ZIMMERMANN, M. ZIOLKOWSKI, R. ZITOUN, L. ZIVKOVIC, V.V. ZMOUCHKO, G. ZOBERNIG, A. ZOCCOLI, Y. ZOLNIEROWSKI, A. ZSENEI, M. ZUR NEDDEN, V. ZUTSHI, Universidade do Minho, and ATLAS Collaboration (ukupan broj autora: 3058)
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Top quark ,FOURTH GENERATION ,Hardron-Hadron Scattering ,01 natural sciences ,7. Clean energy ,Settore FIS/04 - Fisica Nucleare e Subnucleare ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,ddc:539 ,Physics ,Settore FIS/01 - Fisica Sperimentale ,ATLAS ,medicine.anatomical_structure ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Física nuclear ,LHC ,pp collisions ,Particle Physics - Experiment ,Quark ,Nuclear and High Energy Physics ,Particle physics ,Ciências Naturais::Ciências Físicas ,Ciências Físicas [Ciências Naturais] ,FOS: Physical sciences ,ddc:500.2 ,Hadron-hadron scattering ,TOP QUARK ,Electric charge ,Standard Model ,quarks ,Nuclear physics ,Atlas (anatomy) ,0103 physical sciences ,medicine ,ddc:530 ,High Energy Physics ,010306 general physics ,Science & Technology ,010308 nuclear & particles physics ,ATLAS Detector ,High Energy Physics::Phenomenology ,Física ,Charge (physics) ,PERFORMANCE ,Pair production ,HADRON-HADRON COLLISIONS ,Experimental High Energy Physics ,High Energy Physics::Experiment ,Lepton - Abstract
A search is presented for same-sign top-quark production and down-type heavy quarks of charge −1/3 in events with two isolated leptons (e or μ) that have the same electric charge, at least two jets and large missing transverse momentum. The data are selected from pp collisions at √s=7TeV recorded by the ATLAS detector and correspond to an integrated luminosity of 1.04 fb−1. The observed data are consistent with expectations from Standard Model processes. Upper limits are set at 95 % confidence level on the cross section of new sources of same-sign top-quark pair production of 1.4-2.0 pb depending on the assumed mediator mass. Upper limits are also set on the pair-production cross-section for new heavy down-type quarks; a lower limit of 450 GeV is set at 95 % confidence level on the mass of heavy down-type quarks under the assumption that they decay 100 % of the time to W t., We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN: CONICYT, Chile: CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET and ERC, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany: GSRT, Greece; ISF, MINERVA, CIF, Center, Israel; INFN, Italy; MEXT and,JSPS Japan; CNRST, MoroccDIP and Benoziyoo; FOM and NAWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NOGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NI.-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and anBNL (U.S.A.) d in the Tier-2 facilities worldwide., info:eu-repo/semantics/publishedVersion
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- 2012
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116. Second-generation autologous chondrocyte implantation: results in patients older than 40 years
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Giuseppe Filardo, Elizaveta Kon, Vincenzo Condello, Alessandro Di Martino, Marco Collarile, Claudio Zorzi, Maurilio Marcacci, Kon E., Filardo G., Condello V., Collarile M., Di Martino A., Zorzi C., and Marcacci M.
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Adult ,Male ,medicine.medical_specialty ,Arthroplasty, Subchondral ,medicine.medical_treatment ,Physical Therapy, Sports Therapy and Rehabilitation ,Knee Injuries ,Osteoarthritis ,Transplantation, Autologous ,Condyle ,Arthroscopy ,Chondrocytes ,medicine ,Humans ,Orthopedics and Sports Medicine ,In patient ,Autologous chondrocyte implantation ,medicine.diagnostic_test ,business.industry ,Cartilage ,autologous chondrocyte transplantation ,Age Factors ,Middle Aged ,medicine.disease ,Arthroplasty ,Surgery ,Transplantation ,medicine.anatomical_structure ,Female ,business - Abstract
Background Aging is responsible for degenerative changes in all cartilage elements, thus impairing its properties and healing potential. Most studies on surgical procedures for cartilage focus on young patients because these procedures are generally not considered suitable for older patients. Purpose To analyze the clinical outcome of cartilage lesion treatment using second-generation autologous chondrocyte implantation (ACI) techniques in patients more than 40 years old with no clear signs of osteoarthritis, to understand their real potential in relation to aging, the failure rate, and complications in older patients. Study Design Case series; Level of evidence, 4. Methods Sixty-one patients with grade III to IV cartilaginous lesions of the condyles with no clear signs of osteoarthritis and a minimum age of 40 years were treated with second-generation ACI and prospectively evaluated at 5 years’ follow-up. Twenty-two patients were treated with arthroscopic Hyalograft C implantation, and 39 underwent the open Chondro-Gide MACI procedure. Results A significant improvement in both subjective and objective evaluations was observed. The International Knee Documentation Committee (IKDC) subjective score improved from 36.8 ± 8.4 to 68.1 ± 21.8 at the final evaluation. The failure rate was 20%. A faster improvement was observed in the group treated with the arthroscopic Hyalograft C technique, whereas similar scores were found at the 24-month follow-up and final evaluation. Conclusion A clinical improvement was found in patients more than 40 years old, who in most cases benefited from second-generation ACI with good results lasting at medium-term follow-up. However, the results were inferior with respect to those previously found for younger populations, and the failure rate at medium-term follow-up was also higher. These findings were consistent in the 2 treatment groups. The only difference was the faster recovery when the arthroscopic approach was used.
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- 2011
117. Results of isolated posterolateral corner reconstruction
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Claudio Zorzi, Vincenzo Condello, Michele D'Arienzo, Fabrizio Cortese, Vincenzo Madonna, Lawrence Camarda, Camarda, L, Condello, V, Madonna, V, Cortese, F, D'Arienzo, M, and Zorzi, C.
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Surgical results ,Male ,Knee Joint ,Posterolateral corner (PLC) reconstruction ,Tendons ,Postoperative Complications ,Settore MED/33 - Malattie Apparato Locomotore ,Orthopedics and Sports Medicine ,Orthopedic Procedures ,Range of Motion, Articular ,Venous Thrombosis ,Fibular collateral ligament ,Posterolateral corner (PLC) reconstruction, Fibular collateral ligament, Knee ligament reconstruction, Popliteofibular ligament ,Middle Aged ,musculoskeletal system ,Treatment Outcome ,Popliteofibular ligament ,Ligaments, Articular ,Original Article ,Female ,Radiology ,Range of motion ,musculoskeletal diseases ,Adult ,Joint Instability ,Reoperation ,medicine.medical_specialty ,Adolescent ,Knee Injuries ,Transplantation, Autologous ,Young Adult ,medicine ,Posterolateral corner ,Humans ,Retrospective Studies ,Arthritis, Infectious ,business.industry ,Knee ligament reconstruction ,Plastic Surgery Procedures ,Surgery ,Transplantation ,Orthopedic surgery ,Chronic Disease ,business ,Pulmonary Embolism ,Follow-Up Studies - Abstract
Background Isolated posterolateral corner (PLC) tears are relatively rare events. Various surgical techniques to treat posterolateral knee instability have been described; because surgical results are linked to cruciate reconstructions it has been difficult to date to define whether one surgical procedure has better prognosis than another. The goal of this study is to determine the clinical outcome of PLC reconstruction following fibular-based technique. Materials and methods We retrospectively evaluated a case series of patients who received isolated PLC reconstruction between March 2005 and January 2007. Ten patients were surgically treated for isolated injuries and were available for follow-up; average patient age was 27.4 years (range 16–47 years). All patients were treated following the fibular-based technique: double femoral tunnel was performed in six patients, while in the remaining four patients, the reconstruction of the PLC was performed with a single femoral tunnel. Six patients had semitendinosus allograft and four had semitendinosus autograft. All patients had the same evaluation and the same rehabilitation protocol. Results Mean follow-up was 27.5 months (range 18–40 months). Mean range of motion (ROM) was 143.5° for flexion (range 135–150°) and 0.5° for extension (range 0–3°). Three patients showed 1+ on varus stress test, while on Dial test another three patients showed 10° reduction of external rotation compared with contralateral knee. The average Lysholm score was 94 points (range 83–100), and the mean International Knee Documentation Committee (IKDC) subjective result was 88.48 (range 74–96.5). Based on Lysholm score, the results were excellent in eight knees and good in two knees. On IKDC evaluation, two patients were grade A and eight were grade B. No significant difference in clinical results was observed between single and double femoral tunnel. Conclusion Fibular-based technique showed good results in terms of clinical outcome, restoring varus and rotation stability of knees in treatment of chronic isolated PLC injury.
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- 2010
118. Executive dysfunctions in obsessive-compulsive patients and unaffected relatives: searching for a new intermediate phenotype
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Laura Bellodi, Paolo Cavedini, Claudia Zorzi, Monica Piccinni, Maria Cristina Cavallini, Cavedini, P, Zorzi, C, Piccinni, M, Cavallini, Mc, and Bellodi, Laura
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Adult ,Male ,medicine.medical_specialty ,Obsessive-Compulsive Disorder ,Neuropsychological Tests ,behavioral disciplines and activities ,Executive Function ,Wisconsin Card Sorting Test ,mental disorders ,medicine ,Humans ,Family ,Neuropsychological assessment ,Psychiatry ,Biological Psychiatry ,Family Health ,medicine.diagnostic_test ,Cognitive disorder ,Cognitive flexibility ,Middle Aged ,medicine.disease ,Executive functions ,Iowa gambling task ,humanities ,Phenotype ,ROC Curve ,Endophenotype ,Female ,Psychology ,Cognition Disorders ,Neurocognitive - Abstract
Background Evidence in literature suggests that neurocognitive deficits may represent suitable intermediate-phenotype candidates for the dissection of obsessive-compulsive disorder (OCD) genetic heterogeneity. The aim of this study was to search for possible OCD neurocognitive endophenotypes by assessing decision-making, planning, and mental flexibility profiles in OCD probands, healthy control subjects (HC), and their respective relatives. Methods The sample consisted of 35 pairs of OCD probands without other Axis I comorbidities and unaffected first-degree relatives and 31 pairs of HC subjects without a known family history of OCD and their relatives. Neuropsychological assessment was performed using the Iowa Gambling Task (IGT), the Tower of Hanoi (ToH), and the Wisconsin Card Sorting Test (WCST). Results Obsessive-compulsive disorder patients showed impairments in decision making, planning, and mental flexibility, given that OCD probands performed significantly poorer than HC probands at the IGT, the ToH, and the WCST. Obsessive-compulsive disorder relatives performed poorer at these tests than HC probands and relatives. Symptom severity was found to have no influence on neurocognitive performance. Analysis of proband/relative concordance in task performance was performed for each task. A significant overall difference was found when comparing the percentages of the different concordance profiles of our OCD and HC samples with regard to IGT and ToH performance. No significant difference was found in the WCST. Conclusions Executive dysfunctions may qualify as a suitable endophenotype candidate for OCD. Concordance rates in neuropsychological task performance suggest that decision-making and planning deficits aggregate in these families and therefore might be a heritable component of OCD.
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- 2008
119. The advantages of choosing antiobsessive therapy according to decision-making functioning
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Paolo Cavedini, Tommaso Bassi, Laura Bellodi, Claudia Zorzi, Cavedini, P, Bassi, T, Zorzi, C, and Bellodi, Laura
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Adult ,Male ,medicine.medical_specialty ,Obsessive-Compulsive Disorder ,medicine.drug_class ,Decision Making ,Atypical antipsychotic ,Fluvoxamine ,Neuropsychological Tests ,Placebo ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Single-Blind Method ,Psychiatry ,Analysis of Variance ,Risperidone ,Chi-Square Distribution ,Middle Aged ,medicine.disease ,Iowa gambling task ,Psychiatry and Mental health ,Drug Therapy, Combination ,Female ,Psychology ,Reuptake inhibitor ,Chi-squared distribution ,Anxiety disorder ,medicine.drug - Abstract
Objective: Previous studies stressed the role of decision-making functioning in predicting antiobsessive treatment outcome with serotonin reuptake inhibitors drugs in patients with obsessive-compulsive disorder. Nevertheless, the use of an augmentation strategy with atypical antipsychotic drugs has proved to be effective in obsessive-compulsive patients nonresponding to serotonin reuptake inhibitors treatment. We investigated whether the performance at the Iowa Gambling Task (IGT), a used neuro-psychologic task which assesses decision-making, can be an effective criterion for pharmacologic treatment choice in these patients and whether the use of different treatment strategies, according IGT performance, can increase the rate of antiobsessive outcome. Method: Thirty patients with obsessive-compulsive disorder were treated in a single-blind design with fluvoxamine plus placebo or fluvoxamine plus risperidone according to their IGT performance. Treatment outcome was recorded after 6 and 12 weeks. Results: Patients with good IGT performance showed a good antiobsessive treatment outcome with fluvoxamine only, while only adopting an augmentation strategy with risperidone, the number of responders patients within the subjects with bad IGT performance increased. Conclusions: IGT performance may be considered an effective criterion for pharmacologic treatment choice in obsessive-compulsive patients given that antiobsessive treatment outcome is increased to 85% of responders choosing an appropriate drug strategy according to the IGT performance.
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- 2004
120. Results from KLOE at DA Phi NE
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Aloisio, A., Ambrosino, F., Antonelli, A., Antonelli, M., Bacci, C., Bencivenni, G., Bertolucci, S., Bini, C., Bloise, C., Bocci, V., Bossi, F., Branchini, P., Baulychjov, Sa, Caloi, R., Campana, P., Capon, G., Capussela, T., Carboni, G., Cataldi, G., Ceradini, F., Cervelli, F., Cevenini, F., Chiefari, G., Ciambrone, P., Conetti, S., Lucia, E., Simone, P., Zorzi, G., Agnello, S., Denig, A., Di Domenico, A., Di Donato, C., Di Falco, S., Di Micco, B., Doria, A., Dreucci, M., Erriquez, O., Farilla, A., Felici, G., Ferrari, A., Ferrer, Ml, Finocchiaro, G., Forti, C., Franceschi, A., Franzini, P., Gatti, C., Gauzzi, P., Giovannella, S., Gorini, E., Graziani, E., Incagli, M., Kluge, W., Kulikov, V., Lacava, F., Lanfranchi, G., Lee-Franzini, F., Leone, D., Lu, F., Martemianov, M., Matsyuk, M., Mei, W., Merola, L., Messi, R., Miscetti, S., Moulson, M., Muller, S., Murtas, F., Napolitano, M., Nedosekin, A., Nguyen, F., Palutan, M., Pasqualucci, E., Passalacqua, L., Passeri, A., Patera, V., Perfetto, F., Petrolo, E., Pontecorvo, L., Primavera, M., Ruggieri, F., Santangelo, P., Santovetti, E., Saracino, G., Schamberger, Rd, Sciascia, B., Sciubba, A., Scuri, F., Sfiligoi, I., Sibidanov, A., Spadaro, T., Spiriti, E., Testa, M., Tortora, L., Valente, P., Valeriani, B., Venanzoni, G., Veneziano, S., Ventura, A., Ventura, S., Roberto Versaci, Villella, I., Xu, G., Klempt E, Koch H, Orht H, Aloisio, Alberto, Ambrosino, Fabio, Antonelli, A, Antonelli, M, Bacci, C, Bencivenni, G, Bertolucci, S, Bini, C, Bloise, C, Bocci, V, Bossi, F, Branchini, P, Bulychjov, Sa, Caloi, R, Campana, P, Capon, G, Capussela, T, Carboni, G, Cataldi, G, Ceradini, F, Cervelli, Cevenini, F, Chiefari, Giovanni, Ciambrone, P, Conetti, S, De Lucia, E, De Simone, P, De Zorzi, C, Dell'Agnello, S, Denig, A, Di Domenico, A, DI DONATO, Camilla, Di Falco, S, Di Micco, B, Doria, A, Dreucci, T, Erriquez, O, Farilla, A, Felici, G, Ferrari, A, Ferrer, Ml, Finocchiaro, G, Forti, C, Franceschi, A, Franzini, P, Gatti, C, Gauzzi, P, Giovanella, S, Gorini, E, Graziani, E, Incagli, M, Kluge, W, Kulikov, V, Lacava, F, Lanfranchi, G, Lee Franzini, J, Leone, D, Lu, F, Martemianov, M, Matsyuk, M, Mei, W, Merola, Leonardo, Messi, R, Miscetti, S, Moulson, M, Muller, S, Murtas, F, Napolitano, Marco, Nedosekin, A, Nguyen, F, Palutan, M, Pasqualucci, E, Passalacqua, L, Passeri, A, Patera, V, Perfetto, F, Petrolo, E, Pontecorvo, L, Primavera, M, Ruggieri, F, Santangelo, P, Samovetti, E, Saracino, Giulio, Schamberger, Rd, Sciascia, B, Sciubba, A, Scuri, F, Sfiligoi, I, Sibidanov, A, Spadaro, T, Spiriti, E, Testa, M, Tortora, L, Valente, P, Valeriani, B, Venanzoni, G, Veneziano, S, Ventura, A, Ventura, S, Versaci, R, Villella, V, and Xu, G.
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K-S, DECAY, DETECTOR, CALORIMETER ,CALORIMETER ,K-S ,DECAY ,DETECTOR - Published
- 2004
121. Conservative Management of Bowel Endometriosis: Cross-Sectional Analysis for Assessing Clinical Outcomes and Quality-of-Life.
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Ceccaroni M, Baggio S, Capezzuoli T, Albanese M, Mainardi P, Zorzi C, Foti G, and Barra F
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Background/Objectives : Bowel endometriosis (BE) is characterized by the presence of endometrial-like tissue within the muscular layer of the bowel wall. When BE does not result in the severe obstruction to fecal transit and in the absence of (sub)occlusive symptoms, the decision to perform surgery can be challenging, as intestinal procedures are associated with higher complication rates and long-term bowel dysfunction. This cross-sectional study aims to evaluate the quality of life (QoL) in patients with BE who avoided surgery, as well as to investigate the impact of the characteristics of BE nodules on the QoL and intestinal function. Methods : A retrospective cross-sectional analysis was conducted involving 580 patients with BE who did not undergo surgery but were treated conservatively with medical therapy or expectant management between January 2017 and August 2022. The diagnosis of BE was established through transvaginal ultrasound and confirmed via double contrast barium enema. After at least one year of follow-up, the QoL and intestinal function were assessed using the Endometriosis Health Profile-5 (EHP-5) questionnaire and the Bowel Endometriosis Symptom (BENS) score, while pain symptoms were quantified with the Visual Analog Scale (VAS 0-10). Statistical analyses were performed to explore potential associations between the QoL and the characteristics of BE nodules (size, location, and evidence of stenosis), as well as the type and duration of medical therapy. Results : Patients with BE reported a satisfactory overall QoL, with a mean EHP-5 score of 105.42 ± 99.98 points and a VAS score below three across all pain domains. They did not demonstrate significant impairment in bowel function, as indicated by a mean BENS score of 4.89 ± 5.28 points. Notably, patients receiving medical therapy exhibited a better QoL compared to those not receiving treatment ( p < 0.05), with the exception of postmenopausal patients, who reported the highest QoL overall ( p < 0.05). Among the characteristics of BE, nodule location significantly impacted the QoL and symptom intensity, with low (rectal or rectosigmoid) nodules less tolerated compared to sigmoid nodules, particularly regarding non-menstrual pelvic pain (NMPP), dyschezia, and psychological impact on daily life ( p < 0.05). Conclusions : Women can effectively manage BE conservatively in the absence of (sub)occlusive symptoms, even when large nodules are present, causing significant radiological stenosis. The characteristics of BE nodules do not significantly affect the QoL or symptom intensity; however, the location of BE nodules is a crucial factor negatively influencing these outcomes. Medical therapy may confer a beneficial impact on patients of reproductive age with BE, but its use should be carefully considered for those approaching menopause, weighing the risks and benefits.
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- 2024
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122. Mid-term outcomes of medial metal backed and all-polyethylene unicompartmental knee arthroplasty in obese patients: a retrospective propensity-matched analysis.
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De Berardinis L, Piovan G, Screpis D, Senarighi M, Baldini M, Povegliano L, Gigante AP, and Zorzi C
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- Humans, Retrospective Studies, Male, Female, Aged, Middle Aged, Treatment Outcome, Follow-Up Studies, Time Factors, Prosthesis Design, Patient Reported Outcome Measures, Arthroplasty, Replacement, Knee methods, Obesity surgery, Obesity complications, Propensity Score, Metals, Polyethylene, Knee Prosthesis
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Background: This retrospective study compares the outcomes of unicompartmental medial fixed-bearing knee arthroplasty (mUKA), involving a cemented metal-backed (MB) or an all-polyethylene (AP) tibial component, performed in obese patients with a body mass index (BMI) > 30 with a follow-up of at least 5 years., Methods: The institutional database was mined for primary mUKAs involving an MB or an AP tibial component (MB-UKA and AP-UKA groups, respectively) performed from January 2015 to August 2019. Patient demographics and patient-reported outcome measures (PROMs) were compared and a propensity score matching (PSM) analysis (1:1) using multiple variables was conducted., Results: PSM analysis yielded 37 pairs of obese MB-UKA and AP-UKA patients. At 5 years, the Knee Society Function Score (KSFS) was 75.1 ± 10.6 in MB-UKA and 79.4 ± 9.1 in AP-UKA patients (p = 0.029), and the Oxford Knee Score (OKS) was 38.1 ± 4.4 in MB-UKA and 40.6 ± 5.7 in AP-UKA patients (p = 0.011)., Conclusion: At five-year follow-up, in a matched group of obese MB-UKA and AP-UKA patients, the AP-UKA group achieved better KSFSs and OKSs. Both the AP and the MB tibial components were able to bring about a significant improvement of the most widely used PROMs., (© 2024. The Author(s).)
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- 2024
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123. Ultrasonographic characterization of parametrial endometriosis: a prospective study.
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Barra F, Zorzi C, Albanese M, De Mitri P, Stepniewska A, Roviglione G, Giani M, Albertini G, Ferrero S, and Ceccaroni M
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- Humans, Female, Prospective Studies, Adult, Laparoscopy, Ultrasonography methods, Predictive Value of Tests, Young Adult, Reproducibility of Results, Middle Aged, Endometriosis diagnostic imaging, Endometriosis surgery, Endometriosis pathology
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Objective: To study the ultrasonographic diagnostic accuracy and characteristics of parametrial endometriosis comprehensively., Design: This prospective study enrolled patients with suspected deep endometriosis (DE) scheduled for laparoscopic surgical treatment. Preoperative ultrasonographic examinations were performed following the International Deep Endometriosis Analysis criteria. This study aimed to evaluate the presence of parametrial endometriosis and its ultrasonographic characteristics, using surgical diagnosis as the reference standard. Additionally, indirect signs of DE and concomitant DE nodules associated with parametrial involvement were identified, assessing their predictive significance in the anterior, lateral, and posterior parametrial areas., Setting: Referral institution for endometriosis., Patients: Patients with suspected DE scheduled for surgical treatment., Interventions: Standardized preoperative ultrasonographic examination., Main Outcome Measures: The diagnostic accuracy of transvaginal ultrasound in identifying parametrial endometriosis, including sensitivity and specificity, and the ultrasonographic characteristics of parametrial nodules, prevalence in distinct parametrial areas, and associations with indirect DE signs and concomitant DE nodules., Results: Surgical confirmation of parametrial nodules was observed in 105 of 545 patients (left, 18.5; right, 17.0%). Transvaginal ultrasound demonstrated a sensitivity of 77.1% (95% confidence interval, 68.0%-84.8%) and specificity of 99.1% (95% confidence interval, 67.7%-99.8%). Parametrial nodules typically exhibited characteristics such as a mild hypoechoic appearance (83.6%), starry morphology (74.7%), irregular margins (70.2%), and low vascularization. The posterior parametrial region was the most common location (52.2%), followed by the lateral (41.0%) and anterior (6.8%) parametrial regions. Concomitant DE nodules in the rectum (63.5%) and infiltrating the rectovaginal septum (56.5%) were significantly more prevalent in patients with parametrial involvement. Indirect DE signs, such as the ovaries fixed to the uterine wall (71.8%) and the absence of a posterior sliding sign (51.8%), were also more common in women with parametrial nodules. Hydronephrosis, although relatively uncommon in patients with parametrial involvement (8.2%), was largely detected in lateral parametrial nodules (70.0%)., Conclusions: This study represents a systematic ultrasonographic characterization of parametrial endometriosis. Specifically, it comprehensively assesses the diagnostic accuracy of transvaginal ultrasound in identifying parametrial involvement within a sizable cohort of patients with preoperative suspicion of DE., Clinical Trial Registration Number: NCT06017531., Competing Interests: Declaration of Interests F.B. has nothing to disclose. C.Z. has nothing to disclose. M.A. has nothing to disclose. P.D.M. has nothing to disclose. A.S. has nothing to disclose. G.R. has nothing to disclose. M.G. has nothing to disclose. G.A. has nothing to disclose. S.F. has nothing to disclose. M.C. has nothing to disclose., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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124. "From the tip to the deep of the iceberg": Parametrial involvement in endometriosis.
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Barra F, Ferrero S, Zorzi C, Evangelisti G, Perrone U, Valente I, Capezzuoli T, D'Ancona G, Bogliolo S, Roviglione G, and Ceccaroni M
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- Humans, Female, Ultrasonography, Endometriosis pathology, Endometriosis diagnostic imaging, Endometriosis surgery
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Deep endometriosis (DE) can be localized in the parametrium, a complex bilateral anatomical structure, sometimes necessitating intricate surgical intervention due to the potential involvement of autonomic nerves, uterine artery, and ureter. If endometriotic ovarian cysts have been considered metaphorically representative of "the tip of the iceberg" concerning concealed DE lesions, it is reasonable to assert that parametrial lesions should be construed as the most profound region of this iceberg. Also, based on a subdual clinical presentation, a comprehensive diagnostic parametrial evaluation becomes imperative to strategize optimal management for patients with suspected DE. Recently, the ULTRAPARAMETRENDO studies aimed to evaluate the role of transvaginal ultrasound for parametrial endometriosis, showing distinctive features, such as a mild hypoechoic appearance, starry morphology, irregular margins, and limited vascularization. The impact of medical therapy on parametrial lesions has not been described in the current literature, primarily due to the lack of adequate detection at imaging. The extension of DE into the parametrium poses significant challenges during the surgical approach, thereby increasing the risk of intra- and postoperative complications, mainly if performed by centers with low expertise and following multiple surgical procedures where parametrial involvement has gone unrecognized. Over time, the principles of nerve-sparing surgery have been incorporated into the surgical DE treatment to minimize iatrogenic damage and potentially reduce the risk of functional complications., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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125. Surgical and Biological Treatment with a Platelet-Rich Fibrin Matrix for Patellar Tendinopathy: Clinical Outcomes and Return to Sport at 2-Year Follow-Up.
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Iacono V, Padovani L, Qordja F, De Berardinis L, Screpis D, Gigante AP, and Zorzi C
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Background: Patellar tendinopathy (PT) involves anterior knee pain and functional. Platelet-rich fibrin matrix (PRFM) is a promising biological therapy for tendinopathies. We examined a cohort of PT patients treated with tendon debridement and autologous PRFM at the 24-month follow-up to assess whether the combined treatment facilitated return to sports and yielded satisfactory clinical and functional scores., Methods: Baseline and 24-month visual analogue scale (VAS), Victorian Institute of Sport Assessment Scale for Patellar Tendinopathy (VISA-P), Tegner Activity Scale (TAS), and Blazina scores were compared to evaluate treatment effectiveness. The Friedman test was used to compare repeated observations of VAS, VISA-P, TAS, and Blazina Score values. Return to sport rate, Tampa Scale of Kinesiophobia (TKS) score and patient satisfaction were collected at 24 months., Results: The postoperative clinical scores demonstrated significant improvement compared with their preoperative values (all p < 0.001). Specifically, the VISA-P score was 80.32 (±20.58), 92.10% of patients had resumed sports activities and patient satisfaction was 9.21 (±1.21) at 24 months., Conclusions: Surgical debridement and autologous PRFM application in patients with chronic PT resulted in a higher rate of return to sports when compared to solely surgical treatment, significantly improved clinical outcomes and excellent patient satisfaction at 24 months.
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- 2024
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126. Metal-backed or all-poly tibial components: which are better for medial unicompartmental knee arthroplasty? A propensity-score-matching retrospective study at the 5-year follow-up.
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Piovan G, De Berardinis L, Screpis D, Senarighi M, Povegliano L, Natali S, Gigante AP, and Zorzi C
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- Humans, Retrospective Studies, Male, Female, Aged, Follow-Up Studies, Middle Aged, Tibia surgery, Polyethylene, Treatment Outcome, Osteoarthritis, Knee surgery, Arthroplasty, Replacement, Knee methods, Propensity Score, Prosthesis Design, Knee Prosthesis, Patient Reported Outcome Measures, Metals
- Abstract
Background: This retrospective medium-term follow-up study compares the outcomes of medial fixed-bearing unicompartmental knee arthroplasty (mUKA) using a cemented metal-backed (MB) or an all-polyethylene (AP) tibial component., Materials and Methods: The database of our institution was mined for primary mUKA patients implanted with an MB or an AP tibial component (the MB-UKA and AP-UKA groups, respectively) from 2015 to 2018. We compared patient demographics, patient-reported outcome measures (PROMs), and motion analysis data obtained with the Riablo™ system (CoRehab, Trento, Italy). We conducted propensity-score-matching (PSM) analysis (1:1) using multiple variables., Results: PSM analysis yielded 77 pairs of MB-UKA and AP-UKA patients. At 5 years, the physical component summary (PCS) score was 52.4 ± 8.3 in MB-UKA and 48.2 ± 8.3 in AP-UKA patients (p < 0.001). The Forgotten Joint Score (FJS-12) was 82.9 ± 18.8 in MB-UKAs and 73.4 ± 22.5 in AP-UKAs (p = 0.015). Tibial pain was reported by 7.8% of the MB-UKA and 35.1% of the AP-UKA patients (p < 0.001). Static postural sway was, respectively, 3.9 ± 2.1 cm and 5.4 ± 2.3 (p = 0.0002), and gait symmetry was, respectively, 92.7% ± 3.7 cm and 90.4% ± 5.4 cm (p = 0.006). Patient satisfaction was 9.2 ± 0.8 in the MB-UKA and 8.3 ± 2.0 in the AP-UKA group (p < 0.003)., Conclusions: MB-UKA patients experienced significantly better 5-year static sway and gait symmetry outcomes than AP-UKA patients. Although the PROMs of the two groups overlapped, MB-UKA patients had a lower incidence of tibial pain, better FJS-12 and PCS scores, and were more satisfied., (© 2024. The Author(s).)
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- 2024
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127. Double Vector: A Combined Biomechanical and Anatomical Posterolateral Corner Reconstruction Technique.
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Screpis D, Santamaria F, Magnanelli S, De Berardinis L, Natali S, Gigante AP, and Zorzi C
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Posterolateral corner (PLC) injuries are complex knee injuries that are becoming increasingly frequent. Often undiagnosed and underestimated, a systematic diagnostic workup is necessary to assess the severity of PLC injury in order to then be able to select the proper surgery approach. Anatomical and nonanatomical PLC-reconstruction techniques have been described. In this Technical Note, we describe our technique of biomechanical reconstruction of PLC in case of severe posterolateral rotational instability., Competing Interests: The authors report no conflicts of interest in the authorship and publication of this article. Full ICMJE author disclosure forms are available for this article online, as supplementary material., (© 2023 The Authors.)
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- 2024
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128. "Things Have Changed"-Laparoscopic Cytoreduction for Advanced and Recurrent Ovarian Cancer: The Experience of a Referral Center on 108 Patients.
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Ceccaroni M, Roviglione G, Bruni F, Dababou S, Venier M, Zorzi C, Salgarello M, Ruffo G, Alongi F, Gori S, Driul L, Uccella S, and Barra F
- Abstract
Objective: To report the feasibility of laparoscopic cytoreduction surgery for primary and recurrent ovarian cancer in a select group of patients., Methods: A retrospective analysis was conducted on a cohort of patients with FIGO stage IIIA-IV advanced ovarian cancer who underwent laparoscopic primary debulking surgery (PDS), interval debulking surgery (IDS), or secondary debulking surgery (SDS) between June 2008 and January 2020. The primary endpoint was achieving optimal cytoreduction, defined as residual tumor less than 1 cm. Secondary endpoints included evaluating surgical complications and long-term survival, assessed at three-month intervals during the initial two years and then every six months., Results: This study included a total of 108 patients, among whom, 40 underwent PDS, 44 underwent IDS, and 24 underwent SDS. Optimal cytoreduction rates were found to be 95.0%, 97.7%, and 95.8% for the PDS, ISD, and SDS groups, respectively. Early postoperative complications (<30 days from surgery) occurred in 19.2% of cases, with 7.4% of these cases requiring reintervention. One patient died following postoperative respiratory failure. Late postoperative complications (<30 days from surgery) occurred in 9.3% of cases, and they required surgical reintervention only in one case. After laparoscopic optimal cytoreduction with a median follow-up time of 25 months, the overall recurrence rates were 45.7%, 38.5%, and 39.3% for PDS, ISD, and SDS, respectively. The three-year overall survival rates were 84%, 66%, and 63%, respectively, while the three-year disease-free survival rates were 48%, 51%, and 71%, respectively., Conclusions: Laparoscopic cytoreduction surgery is feasible for advanced ovarian cancer in carefully selected patients, resulting in high rates of optimal cytoreduction, satisfactory peri-operative morbidity, and encouraging survival outcomes. Future studies should focus on establishing standardized selection criteria and conducting well-designed investigations to further refine patient selection and evaluate long-term outcomes.
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- 2023
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129. Train vs. Play: Evaluating the Effects of Gamified and Non-Gamified Wheelchair Skills Training Using Virtual Reality.
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Zorzi C, Tabbaa L, Covaci A, Sirlantzis K, and Marcelli G
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This study compares the influence of a gamified and a non-gamified virtual reality (VR) environment on wheelchair skills training. In specific, the study explores the integration of gamification elements and their influence on wheelchair driving performance in VR-based training. Twenty-two non-disabled participants volunteered for the study, of whom eleven undertook the gamified VR training, and eleven engaged in the non-gamified VR training. To measure the efficacy of the VR-based wheelchair skills training, we captured the heart rate (HR), number of joystick movements, completion time, and number of collisions. In addition, an adapted version of the Wheelchair Skills Training Program Questionnaire (WSTP-Q), the Igroup Presence Questionnaire (IPQ), and the Simulator Sickness Questionnaire (SSQ) questionnaires were administered after the VR training. The results showed no differences in wheelchair driving performance, the level of involvement, or the ratings of presence between the two environments. In contrast, the perceived cybersickness was statistically higher for the group of participants who trained in the non-gamified VR environment. Remarkably, heightened cybersickness symptoms aligned with increased HR, suggesting physiological connections. As such, while direct gamification effects on the efficacy of VR-based wheelchair skills training were not statistically significant, its potential to amplify user engagement and reduce cybersickness is evident.
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- 2023
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130. Efficacy and Long-Term Outcomes of Intra-Articular Autologous Micro-Fragmented Adipose Tissue in Individuals with Glenohumeral Osteoarthritis: A 36-Month Follow-Up Study.
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Natali S, Screpis D, Patania E, De Berardinis L, Benoni A, Piovan G, Iacono V, Magnan B, Gigante AP, and Zorzi C
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Background: Glenohumeral osteoarthritis (GOA) is associated with disabling shoulder pain that affects everyday life. Its management comprises various treatment approaches, both conservative and surgical. Regenerative medicine has gained a major role in the conservative treatment of osteoarthritis. Intra-articular injection of adipose-derived mesenchymal stem cells (ADMSCs) is a widely used regenerative medicine approach. The aim of this retrospective study was to report the safety and clinical outcomes of intra-articular injection of ADMSCs in patients with GOA over 36-months., Methods: This retrospective observational study involved patients with chronic shoulder pain resistant to standard conservative treatment and a diagnosis of concentric GOA, who received an intra-articular injection of autologous micro-fragmented adipose tissue (μFAT). The values of the Constant-Murley score (CMS), the visual analog scale (VAS), and the simple shoulder test (SST), collected at baseline and at 12, 24, and 36 months, were analyzed to assess treatment efficacy. The single assessment numeric evaluation (SANE) was used to rate patient satisfaction. The Friedman test was used to compare observations of CMS, VAS, and SST values repeated on the same subjects. The significance threshold was set at 0.05., Results: The participants were 65 patients with a mean age of 54.19 years and a nearly equal gender distribution. Most had mild concentric GOA classified as Samilson-Prieto grade 1. The mean follow-up duration was 44.25 months. The postoperative clinical scores showed significant improvement. At 36 months, the CMS was 84.60, the VAS score was 3.34, and the SST score was 10.15 (all p < 0.0001). The SANE score at 36 months indicated that 54 patients (83.08%) were completely satisfied with the treatment., Conclusion: ADMSC treatment exerted favorable effects on the clinical outcomes of patients with GOA, providing pain relief and improving shoulder function. Our data support its use as a conservative treatment option for osteoarthritis.
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- 2023
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131. Dual-Energy CT Arthrography: Advanced Muscolo-Skelatal Applications in Clinical Practice.
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Foti G, Booz C, Buculo GM, Oliboni E, Longo C, Avanzi P, Campacci A, and Zorzi C
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- Tomography, X-Ray Computed, Arthrography, Contrast Media
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This paper provides a comprehensive overview of the potential applications of dual-energy CT (DECT) in improving image quality and the diagnostic capabilities of CT arthrography (CTA) in clinical practice. The paper covers the use of virtual non-contrast (VNC) images, in which the injected contrast medium is subtracted from the articular cavity in order to better analyze 2D and 3D images of the bone. Moreover, virtual monoenergetic imaging (VMI) applications and their potential use for the reduction of metal artifacts and improving image contrast are reviewed. The role of virtual non-calcium (VNCa) in detecting bone marrow edema surrounding the imaged joint will be discussed. Furthermore, the role of iodine maps in enhancing the contrast between soft tissues, optimizing the visualization of contrast material, and distinguishing contrast material from calcifications is described. Finally, a case series including different joints is provided to underline the additional advantages of high-spatial-resolution dual-energy CT reconstructed images.
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- 2023
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132. Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year follow-up.
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Natali S, Screpis D, Romeo M, Magnanelli S, Rovere G, Andrea A, Camarda L, and Zorzi C
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- Humans, Follow-Up Studies, Transplantation, Autologous methods, Injections, Intra-Articular methods, Adipose Tissue, Treatment Outcome, Osteoarthritis, Hip surgery, Osteoarthritis, Knee surgery
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Background: Recently, increased attention on regenerative medicine and biological injective treatments have been proposed to restore native cartilage. Micro-fragmented adipose tissue (MFAT) has been studied for its anti-inflammatory, paracrine, and immunomodulatory effects. The long-term effects of MFAT are still poorly understood: the aim of the present study is to demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes., Methods: Seventy-one consecutive patients affected by early hip osteoarthritis underwent an ultrasound-guided hip injection of autologous MFAT between June 2017 and December 2018. Patients were divided into four groups according to the Oxford Hip Score. All patients received 4 mL of autologous micro-fragmented adipose tissue under an ultrasound guide. A clinical evaluation was done between 29 and 41 months after the initial treatment. During this follow-up period, we recorded any new treatment the patients had done, whether that be injection or arthroplasty surgery., Results: The study included 55 patients. Out of 55 patients, 28 saw benefits and were in no need of further treatment. Moreover, the score between the beginning and control increased by 6.9 points. Ten patients underwent a new articular injection: the mean time between the two injections was 635.7 ± 180 days. Seventeen patients underwent total hip replacement: the mean period between the autologous MFAT injection and the surgery was 495 days., Conclusion: This study found that intra-articular injections with autologous MFAT achieve beneficial clinical results in patients affected by early to moderate hip osteoarthritis, with an OHS between 48 and 30. Furthermore, these subjects are the ideal patients for whom this treatment obtains good clinical results., (© 2022. The Author(s).)
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- 2023
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133. Moist and warm conditions in Eurasia during the last glacial of the Middle Pleistocene Transition.
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Sánchez Goñi MF, Extier T, Polanco-Martínez JM, Zorzi C, Rodrigues T, and Bahr A
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The end of the Middle Pleistocene Transition (MPT, ~ 800-670 thousand years before present, ka) was characterised by the emergence of large glacial ice-sheets associated with anomalously warm North Atlantic sea surface temperatures enhancing moisture production. Still, the direction and intensity of moisture transport across Eurasia towards potential ice-sheets is poorly constrained. To reconstruct late MPT moisture production and dispersal, we combine records of upper ocean temperature and pollen-based Mediterranean forest cover, a tracer of westerlies and precipitation, from a subtropical drill-core collected off South-West Iberia, with records of East Asia summer monsoon (EASM) strength and West Pacific surface temperatures, and model simulations. Here we show that south-western European winter precipitation and EASM strength reached high levels during the Marine Isotope Stage 18 glacial. This anomalous situation was caused by nearly-continuous moisture supply from both oceans and its transport to higher latitudes through the westerlies, likely fuelling the accelerated expansion of northern hemisphere ice-sheets during the late MPT., (© 2023. The Author(s).)
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- 2023
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134. Return to Sports and Functional Outcomes after Autologous Platelet-Rich Fibrin Matrix (PRFM) and Debridement in Midportion Achilles Tendinopathy: A Case Series with 24-Month Follow-Up.
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Iacono V, Natali S, De Berardinis L, Screpis D, Gigante AP, and Zorzi C
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(1) Background: Achilles tendinopathy (AT) is characterized by load-induced tendon pain, stiffness, and functional impairment that may affect the tendon midportion or insertion. Platelet-rich fibrin matrix (PRFM) is a promising adjunctive therapy for AT. We analyzed 24-month pain and functional outcomes in a cohort of patients managed by tendon debridement and autologous PRFM application to determine whether the combined treatment ensured an early return to sports/work and satisfactory clinical outcomes and functional scores. (2) Methods: The 24-month outcomes of 32 sport-practicing patients with chronic midportion AT treated with debridement and autologous PRFM were evaluated in terms of time to return to sports/work. The AOFAS and VISA-A were computed preoperatively and at 6 and 24 months. Blazina scores were evaluated preoperatively and at 6 months; ankle range of motion was assessed at 1, 6, 12, 24 months; and patient satisfaction was assessed at 24 months. (3) Results: Altogether, all patients had resumed their sport(s) activity, at the same or higher level, after 25.41 days (±5.37). Regarding work, all patients were able to return to their jobs after 16.41 days (±2.43). Ankle dorsiflexion and plantarflexion increased significantly: the AOFAS rose from 54.56 (±6.47) to 97.06 (±4.06) and 98.88 (±2.21) at 6 and 12 months, respectively, and the mean VISA-A score rose from 69.16 (±7.35) preoperatively to 95.03 (±4.67) and 97.28 (±2.43) at 6 and 12 months, respectively, after treatment. There were no complications. Most (90.62%) patients were very satisfied. (4) Conclusions: In symptomatic midportion AT, surgical debridement and autologous PRFM ensured a fast return to sports/work (4 weeks), significantly improving AOFAS and VISA-A and Blazina scores already at 6 months and providing excellent clinical outcomes at 24 months.
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- 2023
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135. Long-Term Survival and Predictors of Failure of Opening Wedge High Tibial Osteotomy.
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Guarino A, Farinelli L, Iacono V, Cozzolino A, Natali S, Zorzi C, and Mariconda M
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- Humans, Male, Adolescent, Young Adult, Adult, Middle Aged, Aged, Female, Treatment Outcome, Retrospective Studies, Tibia surgery, Knee Joint surgery, Osteotomy methods, Obesity, Osteoarthritis, Knee surgery
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Objective: High tibial valgus osteotomy (HTO) is a widely accepted procedure indicated for varus knee with symptomatic osteoarthritis of the medial compartment. However, there is a lack of studies evaluating long term results of this procedure. The primary aim of this study was to evaluate the long-term survival of opening wedge high tibial osteotomy (HTO) for isolated osteoarthritis in the medial compartment of the knee. The secondary objective was to identify independent predictors of conversion to total knee arthroplasty (TKA)., Methods: This is a long term retrospective study of 296 cases of open wedge HTOs performed at a single center (level of evidence IV) between January 2005 and August 2015. Opening wedge medial HTO was always performed after diagnostic arthroscopy. Eighty-three percent of the population (233 patients, 247 procedures) was followed up at a mean 11.6 years (6-17) by telephone interview, to evaluate the possible conversion to TKA. Mean age at the index operation was 42.8 years (range 15-70) and most patients were male (70%). Associated procedures (e.g., platelet rich plasma supplementation, microfractures, meniscectomy, etc.) were carried out at the time of the HTO in 80 (32%) cases. Survival of HTO and its association with age, sex, body mass index, smoking habit, preoperative severity of varus deformity, cartilage status at surgery, and associated procedures were evaluated. Kaplan-Meier and Cox regression analyses were performed., Results: Thirty-three of the 247 HTOs (13.4%) were converted to knee replacement, with 86.6% of the original procedures surviving at a mean 12-year follow-up. Kaplan-Meier survival estimates at 17 years for HTO were 75.5% (95% confidence interval [CI] 66.7-84.3). There was significant difference (P < 0.001) in the 17-year survival rate between obese (55.5%; 95% CI 35.3-75.6) and non-obese (79.7%; 95% CI 70.1-89.2) patients. The determinants of conversion to knee arthroplasty detected at multivariate Cox regression analysis were body mass index, severity of cartilage degeneration in the medial compartment (Outerbridge grade), and age., Conclusion: The long-term survival of open wedge HTO for osteoarthritis in the medial compartment of the knee is satisfactory. The risk of conversion to TKA is significantly increased in obese patients. Advanced age and severity of pre-existing cartilage damage may also contribute to the risk of conversion to TKA., (© 2023 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.)
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- 2023
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136. Why to Use an Old Map to Explore a New World? The Time for Considering an Ultrasonographic Parametrial Topography Has Come.
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Ceccaroni M, Zorzi C, Albanese M, Clarizia R, Stepniewska AK, Roviglione G, Ferrero S, and Barra F
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- Female, Humans, Endometriosis diagnostic imaging, Ultrasonography
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- 2023
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137. Dual-Energy CT for Detecting Painful Knee Prosthesis Loosening.
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Foti G, Longo C, D'Onofrio M, Natali S, Piovan G, Oliboni E, Iacono V, Guerriero M, and Zorzi C
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- Female, Humans, Knee Joint, Prospective Studies, Prosthesis Failure, Radiography, Radiography, Dual-Energy Scanned Projection methods, Tomography, X-Ray Computed methods
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Background Dual-energy CT (DECT) is an alternative to radiography and single-energy CT (SECT) for detecting prosthesis-related complications. Purpose To compare the diagnostic performance of DECT, SECT, and radiography for knee prosthesis loosening, with use of surgery or imaging follow-up reference standards. Materials and Methods In this prospective single-center study from December 2018 to June 2021, participants with unilateral painful knee prostheses underwent radiographic, SECT, and DECT imaging. Five blinded readers, four radiologists, and one orthopedic surgeon evaluated the images. Prosthesis loosening was diagnosed by a periprosthetic lucent zone greater than 2 mm. The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of each method were determined and compared with use of a multireader multicase analysis. Results There were 92 study participants (mean age ± SD, 70 years ± 9.4; 67 women) evaluated. Tibial and femoral loosening were diagnosed in 47 and 24 participants, respectively. For the tibia, mean sensitivity and specificity for arthroplasty loosening were 88% and 91%, respectively, for DECT, 73% and 78% for SECT, and 68% and 81% for radiography. For the tibia, DECT demonstrated similar diagnostic performance (AUC, 0.90) to SECT (AUC: 0.90 vs AUC: 0.87, respectively; P = .13) but was superior to radiography (AUC: 0.90 vs AUC: 0.82; P = .002). Overall diagnostic performance of DECT (AUC, 0.87) for the femur was superior to both SECT and radiography ( P < .001). Conclusion Dual-energy CT had generally better diagnostic performance in detecting loosening of tibial and femoral components after total knee arthroplasty compared with single-energy CT or radiography. Clinical trial registration no. 2942 © RSNA, 2022.
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- 2023
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138. Arthroscopic Superior Capsular Reconstruction (ASCR): All Soft Anchors Technique.
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Avanzi P, Cardoni G, and Zorzi C
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Rotator cuff tears are among the most common orthopaedic injuries. If not treated, they can result in a massive irreparable tear because of tendon retraction and muscle atrophy. Mihata et al. in 2012 described the technique of superior capsular reconstruction (SCR) using fascia lata autograft. This has been considered an acceptable and effective method for treating irreparable massive rotator cuff tears. We describe an arthroscopically assisted superior capsular reconstruction (ASCR) technique using all soft anchors to preserve the bone stock and reduce possible hardware complications. Moreover, knotless anchors for the lateral fixation make the technique easier to reproduce., (© 2022 The Authors.)
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- 2023
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139. Anatomic Combined Anterior Cruciate Ligament and Antero-Lateral Ligament Reconstruction Using Autologous Gracilis and Semitendinosus Graft With Single Tibial and Femoral Tunnel.
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Screpis D, Baldini M, Magnanelli S, Amarossi A, Piovan G, Natali S, and Zorzi C
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Anterior cruciate ligament (ACL) injuries are among the most common lesions in orthopaedics practice, but still today, rates up to 24% of unsatisfactory results are reported. Unaddressed anterolateral complex (ALC) injuries have been claimed to be responsible for residual anterolateral rotatory instability (ALRI) after isolate ACL reconstruction and have demonstrated to increase graft failure. In this article, we present our technique for reconstruction of the ACL and anterolateral (ALL) ligament combining the advantages of the anatomical position and the intraosseous femoral fixation to ensure anteroposterior and anterolateral rotational stability., (© 2022 The Authors.)
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- 2023
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140. Ultrasonographic Findings Indirectly Predicting Parametrial Involvement in Patients with Deep Endometriosis: The ULTRA-PARAMETRENDO I Study.
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Barra F, Zorzi C, Albanese M, Stepniewska A, Deromemaj X, De Mitri P, Roviglione G, Clarizia R, Gustavino C, Ferrero S, and Ceccaroni M
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- Humans, Female, Sensitivity and Specificity, Retrospective Studies, Rectum pathology, Vagina diagnostic imaging, Vagina surgery, Vagina pathology, Ultrasonography methods, Endometriosis complications, Endometriosis diagnostic imaging, Endometriosis surgery, Laparoscopy methods, Peritoneal Neoplasms surgery
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Study Objective: To evaluate ultrasonographic findings as a first-line imaging tool to indirectly predict the presence of parametrial endometriosis (PE) in women with suspected deep endometriosis (DE) undergoing surgery., Design: Retrospective analysis of a prospectively collected database (ULTRA-PARAMETRENDO I study; NCT05239871)., Setting: Referral center for DE., Patients: Consecutive patients undergoing laparoscopic surgery for DE., Interventions: Preoperative transvaginal ultrasonography was done according to the International Deep Endometriosis Analysis consensus statement. A stepwise forward regression analysis was performed considering the simultaneous presence of DE nodules and the following ultrasonographic indirect signs of DE: diffuse adenomyosis, endometriomas, ovary fixed to the lateral pelvic wall or the uterine wall, absence of anterior/posterior sliding sign, and hydronephrosis. The gold standard for the presence of PE was surgery with histologic confirmation., Measurements and Main Results: Of 1079 patients, 212 had a surgical diagnosis of PE (left: 18.5%; right: 17.0%; bilateral: 15.9%). The obtained prediction model (χ
2 = 222.530; p <.001) for PE included, as independent indirect DE signs presence of hydronephrosis (odds ratio [OR] = 14.5; p = .002), complete absence of posterior sliding sign (OR = 3.3; p <.001), presence of multiple endometriomas per ovary (OR = 3.0; p = .001), and ovary fixation to the uterine wall (OR = 2.4; p <.001); as independent concomitant DE nodules, presence of uterosacral nodules with the largest diameter >10 mm (OR = 3.2; p <.001), presence of rectal endometriosis with the largest diameter >25 mm (OR = 2.3; p = .004), and rectovaginal septum infiltration (OR = 2.3; p = .003). The optimal diagnostic balance was obtained considering at least 2 concomitant DE nodules and at least 1 indirect DE sign (area under the curve 0.75; 95% confidence interval, 0.72-0.79)., Conclusion: Specific indirect ultrasonographic findings should raise suspicion of PE in women undergoing preoperative assessment for DE. The suspicion of parametrial invasion may be critical to address patients to expert leading centers, where proper diagnosis and surgical treatment for PE can be performed., (Copyright © 2022 AAGL. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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141. The role of antibiotic calcium sulfate beads in acute periprosthetic knee infection: a retrospective cohort study.
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Piovan G, Farinelli L, Screpis D, Marocco S, Motta L, Palazzolo G, Natali S, and Zorzi C
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Background: The study aimed to compare debridement, antibiotics, and implant retention (DAIR) vs. debridement antibiotic bead and retention of the implant (DABRI) in terms of infection-free success rate and treatment cost for acute periprosthetic joint infections after total knee arthroplasty (TKA)., Method: Between 2017 and 2020, 32 patients with acute periprosthetic joint infection who were treated by total knee arthroplasty were retrospectively reviewed. The patients were divided into a DAIR group (n=15) and a DABRI group (n=17). During the DABRI, additional calcium ulphate antibiotic beads were used. Patient age, the Musculoskeletal Infection Society score, microorganisms involved, and success rate were assessed., Results: The mean age of DAIR group (n=15) was 69 years, with 7 being male, and 8 female. The mean follow-up period lasted 30 months. The success rate was 80% (12/15). The mean age of DABRI group (n=17) was 64 years, with 10 patients being male and 7 female. The mean follow-up period was 16 months. The success rate was 88% (15/17). There were no significant differences in patient age (P>0.05), the Musculoskeletal Infection Society score (P>0.05), and success rate (P>0.05). A significant difference was found in the follow-up period between the two groups (P<0.05)., Conclusion: Both DAIR and DABRI could be used to treat acute periprosthetic joint infections and the outcomes and treatment costs of the two procedures were comparable. Additional use of calcium sulfate beads was safe, but might not improve the treatment result. Randomized controlled studies are warranted for the routine use., (© 2022. The Author(s).)
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- 2022
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142. Simultaneous Bilateral Total Knee Arthroplasty in Elderly: Are There Factors that Can Influence Safety and Clinical Outcome?
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Piovan G, Screpis D, Natali S, Iacono V, Baldini M, Farinelli L, Guerriero M, and Zorzi C
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Objective: The aim of this study was to look for preoperative patients' related factors correlating with worse clinical outcomes in a cohort of elderly patients undergoing simultaneous bilateral total knee arthroplasty (SiBTKA) to search for risk factors, which may influence clinical outcomes and safety. Subjects and Methods . The hospital database was mined searching for patients older than 70 years that underwent SiBTKA for severe bilateral knee osteoarthritis (OA) between 2012 and 2016. Preoperative clinical information, Oxford Knee Score (OKS), and Knee Injury and Osteoarthritis Outcome Score (KOOS) prior to surgery were recorded. The OKS and the KOOS were submitted again after a minimum of 5 years of follow-up (FU)., Results: An improvement was observed in all clinical scores at last FU. The major complication rate was 5.4%. No patients' clinical data showed correlation with perioperative complications or need for transfusions. Functional scores at the last FU were negatively affected by age at surgery and positively affected by preoperative clinical scores. Discussion . In the setting of severe symptomatic bilateral knee OA, SiBTKA seems to be effective in improving symptoms at midterm follow-up, with acceptable rates of perioperative complications in patients older than 70. Higher age at surgery and lower preoperative functional scores are associated with worse clinical outcomes at FU. This could assist surgeons in advising patients that delay of surgical treatment could worsen outcomes., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2022 G. Piovan et al.)
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- 2022
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143. Distal femoral osteotomy versus lateral unicompartmental arthroplasty for isolated lateral tibiofemoral osteoarthritis with intra-articular and extra-articular deformity: a propensity score-matched analysis.
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Piovan G, Farinelli L, Screpis D, Iacono V, Povegliano L, Bonomo M, Auregli L, and Zorzi C
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Purpose: Lateral unicompartmental arthroplasty (UKA) and distal femoral osteotomy (DFO) represent surgical solutions in cases of valgus malalignment and isolated lateral osteoarthritis (OA) of the knee. The aim of the present study was to assess the clinical results, complications, and the overall postoperative alignment of a series of DFO and lateral UKA with a minimum 2-year follow-up in active middle-aged patients., Methods: Patients with valgus knee and isolated lateral OA who underwent opening-wedge DFO or UKA from 2017 to 2019 were reviewed. Each patient was characterized by a joint line convergence angle (JLCA) > 3° and mechanical lateral distal femoral angle (mLDFA) < 87°. We excluded patients who underwent meniscus or osteochondral allograft during DFO. The Oxford Knee Score (OKS), Knee Injury and Osteoarthritis Outcome Score (KOOS), complications, and postoperative alignment were assessed. Propensity score matching was used to identify comparable patients., Results: The DFO and lateral UKA groups consisted of 29 patients each. No statistically significant differences in gender, age, body mass index (BMI), length of follow-up, or limb deformity were reported between the two groups. In the DFO group, OKS was reported to improve from 27.51 to 38.59 (p < 0.05) and KOOS from 51.14 to 67.2 (p < 0.05). Similarly, in the UKA group, OKS improved from 26.23 to 35.43 (p < 0.05) and KOOS from 50.12 to 65.91 (p < 0.05). However, the improvement in OKS and KOOS (delta) did not differ between groups (p = 0.35 and p = 0.95). The DFO and UKA groups were characterized by similar postoperative hip-knee-ankle (HKA) angle measurements of -3.26 and -3.00, respectively (p = 0.65). No patients in the UKA group underwent revision or other knee surgeries during follow-up. No infections were detected in either group. In the DFO group, no cases of nonunion or delayed union were reported. However, 40% of DFO patients underwent plate removal. One patient in each group was characterized by progression of medial OA with Kellgren-Lawrence (KL) grade > 3., Conclusion: UKA and DFO represent an effective treatment in lateral knee OA with intra-articular and extra-articular deformity. Both surgeries were able to provide a significant and comparable clinical improvement., Level of Evidence: III, comparative retrospective cohort study., (© 2022. The Author(s).)
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- 2022
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144. Human Amniotic Suspension Allograft Improves Pain and Function in Knee Osteoarthritis: A Prospective Not Randomized Clinical Pilot Study.
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Natali S, Farinelli L, Screpis D, Trojan D, Montagner G, Favaretto F, and Zorzi C
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Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of joints. Among various cell therapies, mesenchymal stem cell (MSC) therapy appears to provide encouraging results. Human amniotic suspension allografts (HASA) have anti-inflammatory and chondroregenerative potential and represent a promising treatment strategy. The purpose of the present study was to prospectively assess the safety, clinical effectiveness, and feasibility of intra-articular injections of human amniotic suspension allograft (HASA) in unilateral knee OA in order to assess the improvement of symptoms and delay the necessity for invasive surgical procedures. A total of 25 symptomatic patients, affected by knee OA were treated with 3 mL of HASA. Clinical evaluations before the treatment and after 3, 6, and 12 months were performed through International Knee Documentation Committee (IKDC) score and Visual Analogue Scale (VAS) scores. Adverse events were recorded. No severe complications were noted during the treatment and the follow-up period. A statistically significant improvement from basal evaluation to the 3-, 6-, and 12-month follow-up visits was observed. The present pilot study indicates that a single intra-articular injection of HASA seems safe and able to provide positive clinical outcomes, potentially offering a new minimally invasive therapeutic option for patients with knee OA.
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- 2022
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145. Lateral extra-articular tenodesis and anterior cruciate ligament reconstruction in young patients: clinical results and return to sport.
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Guarino A, Farinelli L, Iacono V, Screpis D, Piovan G, Rizzo M, Mariconda M, and Zorzi C
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Lateral extra-articular tenodesis (L.E.T.) have been proposed to reduce the tibia's anterior translation and internal rotation in concomitant to Anterior cruciate ligament (A.C.L.) reconstruction. Recent studies show that the addition of L.E.T. to A.C.L. reconstruction results in a statistically significant reduction in graft failure. The purpose of the present study was to evaluate the clinical outcomes, complications, and rate of return to preinjury sports level in pediatric patients who underwent combined A.C.L. reconstruction with L.E.T. at a minimum 2-year follow-up. The authors retrospectively evaluated 42 pediatric patients at high risk of graft failure who experienced ACLR connected to L.E.T. IKDC and Tegner-Lysholm Knee Scores Scale were used to assess clinical outcomes, and the Tegner Activity Scale to evaluate the return to sport. No graft failure or subsequent surgery related to A.C.L. reconstruction occurred. Furthermore, 88% of patients returned to the sport. Satisfactory clinical results were obtained on a short and medium-term follow-up. These findings help to consider this procedure for active adolescents at a high risk of graft failure to enhance A.C.L. reconstruction., Competing Interests: All authors declare that there is no conflict of interest.
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- 2022
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146. Tibial Tubercle Screw Fixation on Custom Metaphyseal Cone: Surgical Tip in Severe Metaphyseal Tibia Bone Loss.
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Piovan G, Farinelli L, Screpis D, Povegliano L, Gigante AP, and Zorzi C
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Tibial tubercle osteotomy (TTO) facilitates exposure in knee arthroplasty revision. However, it comes with complications, especially if it invades the intramedullary canal. Most revisions are characterized by compromised femur and/or tibia bone stock, and the use of metaphyseal cones or sleeves for implant fixation has become increasingly frequent. Several methods of fixation of the tibial tubercle have been proposed, such as screw fixation, cerclage wiring, and suture repair. Despite screws providing the strongest fixation for TTO, their placement around a tibial intramedullary stem or a metaphyseal tibial cone may be difficult. We described the use of a custom-made metaphyseal tibial cone with holes in its anterior surface that allow the surgeon to achieve accurate TTO fixation by screws., (© 2022 The Authors.)
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- 2022
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147. Traumatic biceps femoris tendon subluxation in a young football player.
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Padovani L, Iacono V, Auregli L, Guarino A, Natali S, Zorzi C, and Mariconda M
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Snapping a knee related to a biceps femoris tendon subluxation is an uncommon syndrome that could be disabling in patients with high functional requirements such as athletes. We report a case of a 21-year-old soccer player with a painful left snapping biceps femoris tendon due to a varus trauma. He underwent knee arthroscopy and surgical exploration of the knee: the long head of the biceps femoris tendon was partially detached from his fibular insertion and there was a prominence on the fibular head. Reinsertion of the tendon and osteotomy of the fibular head allowed for resolution of all symptoms and the return to sport., Competing Interests: All authors declare that there is not any conflict of interest.
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- 2022
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148. Autologous Microfragmented Adipose Tissue for the Treatment of Knee Osteoarthritis: Real-World Data at Two Years Follow-Up.
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Screpis D, Natali S, Farinelli L, Piovan G, Iacono V, de Girolamo L, Viganò M, and Zorzi C
- Abstract
The purpose of the present study was to assess, prospectively, the safety, clinical effectiveness, and feasibility of a single intra-articular injection of microfragmented adipose tissue in different stages of knee osteoarthritis (OA). The study included patients (aged 18−70 years), affected by OA (Kellgren−Lawrence I-IV). Unselected patients were evaluated before and prospectively after 6, 12, and 24 months from the injection. Visual analog scale (VAS) and knee injury and osteoarthritis outcome score (KOOS) were used for clinical evaluations. A total of 202 patients were eligible. The mean follow-up time in the cohort of patients was 24.5 ± 9.6 months. Total KOOS significantly improved from pre-operative baseline levels to 6-month follow-up (p < 0.001), and again between 6- and 12-month follow-ups (p < 0.001). The VAS showed a prompt reduction at 6 months (p < 0.001 vs. baseline), but then it increased again at 12 months compared to the 6-month assessment (p < 0.001), even though it remained lower than baseline (p < 0.001). At 24 months, patients with KL-IV demonstrated a lower improvement compared to baseline; patients that had undergone previous corticosteroid injections had a greater risk to further injection treatment. The collected clinical results suggest that MFAT may represent a safe and effective treatment for OA symptoms, offering a low-demanding and minimally invasive treatment.
- Published
- 2022
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149. Role of ultrasonographic parameters for predicting tubal involvement in infertile patients affected by endometriosis: A retrospective cohort study.
- Author
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Stepniewska AK, Clarizia R, De Mitri P, Pesci A, Zorzi C, Albanese M, Trivella G, Guerriero M, Improda FP, and Ceccaroni M
- Subjects
- Adult, Cohort Studies, Endometriosis physiopathology, Fallopian Tube Diseases epidemiology, Fallopian Tubes diagnostic imaging, Female, Humans, Infertility, Female epidemiology, Infertility, Female etiology, Italy epidemiology, Retrospective Studies, Ultrasonography statistics & numerical data, Endometriosis complications, Fallopian Tube Diseases diagnostic imaging, Fallopian Tube Diseases etiology, Ultrasonography methods
- Abstract
Introduction: Transvaginal ultrasound is fundamental for the mapping of endometriosis, and the imaging criteria have been clearly described for different organs study. However, no specific ultrasonographic signs of tubal endometriosis have been reported, with the exception of hydrosalpinx, which is the expression of an extreme tubal damage and obstruction. The detection of tubal pathology in infertile patients is fundamental, therefore the aim of the study was to evaluate incidence of tubal endometriosis in infertile patients, and to analyze ultrasonographic signs useful for detection of this condition., Material and Methods: It is a single-center, retrospective cohort study. All 500 consecutive infertile women who underwent laparoscopic surgery for endometriosis were included. The preoperative workup included transvaginal ultrasound and was compared to intraoperative findings and histologic study., Results: The incidence of tubal endometriosis in our study was 8%. Using hydrosalpinx as the ultrasonographic marker for tubal involvement the overall pooled, sensitivity and specificity of TVU were 12% (95%CI, 5-23%) and 99% (95%CI, 98-100%), respectively. If at least one ultrasonographic parameter like hydrosalpinx, periadnexal adhesions or ovarian cyst was considered as a sign of tubal endometriosis, a sensitivity, VPN and specificity were 94% (95% IC, 85-98%), 97% (95%IC, 93-99%) and 31% (95%CI, 27-36%), respectively., Discussion: Hydrosalpinx as ultrasonographic sign alone is characterized by a high specificity but low sensitivity for detection of tubal endometriosis; its sensitivity can be improved by the addition of other markers such as endometrioma and/or periadnexal adhesions., Competing Interests: Declaration of Competing Interest The authors declare that they wave no conflicts of interest and nothing to disclose., (Copyright © 2021. Published by Elsevier Masson SAS.)
- Published
- 2021
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150. The use of autologous platelet-rich fibrin matrix combined with meniscal repair in the treatment of parameniscal cyst: clinical results and cyst recurrence after 2-year of follow up.
- Author
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Screpis D, Piovan G, Natali S, Pasqualotto S, Magnanelli S, Iacono V, Farinelli L, Grassi M, and Zorzi C
- Abstract
Purpose: Parameniscal cysts are associate with horizontal meniscal tears. Arthroscopic meniscal repair and the excision of the cyst by mini-open approach represent a valid treatment. However, the recurrence of cyst is still a current issue. Therefore, biological factors may be considered to promote the biological repair and avoid recurrence. The aim of the present study was to report the clinical results and the rate of recurrence of the cyst after minimum 2-year of follow up in a cohort of patients treated by meniscal repair and autologous platelet-rich fibrin matrix augment., Methods: Patients with lateral parameniscal cyst undergoing arthroscopic meniscal repair and autologous platelet-rich fibrin matrix augment between 2016 and 2019 were retrospectively reviewed in March 2021. Inclusion criteria were absence of prior surgery on the affected knee with minimum 2-year of follow-up. Exclusion criteria were concomitant ligament lesions, rheumatic diseases and knee osteoarthritis. After reviewing the database, each selected patient was contacted and asked to participate in the study; at the follow-up evaluation all patient signed an informed consent. Tegner-Lysholm knee score, IKDC and NRS were collected before surgery and at follow-up., Results: This study included 15 patients (8 male) with mean age of 32.8 years old. No recurrence of the cysts was observed. The Tegner-Lysholm knee score and IKDC subjective scores increased respectively from 41.3 ± 5.4 and 37.6 ± 5.1 at baseline to 92.3 ± 4.6 and 89.4 ± 2.6 at the final follow up. Concerning pain relief, the Numeric Pain Rating Scale (NRS) displayed a significant improvement reaching at the follow up a score of 1,3 ± 1.1 in comparison to 6.8 ± 0.9 at the baseline., Conclusion: Surgical management of symptomatic lateral parameniscal cyst with cyst excision, autologous PRP membrane application and meniscus repair demonstrated excellent subjective clinical outcome with any cyst reoccurrence., Level of Evidence: III, retrospective cohort study., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
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