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105. Selection of the Optimal Candidate to MitraClip for Secondary Mitral Regurgitation: Beyond Mitral Valve Morphology

Author

Salvatore, Tanya, primary, Ricci, Fabrizio, additional, Dangas, George D., additional, Rana, Bushra S., additional, Ceriello, Laura, additional, Testa, Luca, additional, Khanji, Mohammed Y., additional, Caterino, Anna Laura, additional, Fiore, Corrado, additional, Popolo Rubbio, Antonio, additional, Appignani, Marianna, additional, Di Fulvio, Maria, additional, Bedogni, Francesco, additional, Gallina, Sabina, additional, and Zimarino, Marco, additional

Published
2021
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113. Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study

Author

Yacob, Omar, primary, Garcia-Garcia, Hector M., additional, Dan, Kazuhiro, additional, Soud, Mohamad, additional, Adamo, Marianna, additional, Picchi, Andrea, additional, Sardella, Gennaro, additional, Frigoli, Enrico, additional, Limbruno, Ugo, additional, Rigattieri, Stefano, additional, Diletti, Roberto, additional, Boccuzzi, Giacomo, additional, Zimarino, Marco, additional, Contarini, Marco, additional, Russo, Filippo, additional, Calabro, Paolo, additional, Ando, Giuseppe, additional, Varbella, Ferdinando, additional, Garducci, Stefano, additional, Palmieri, Cataldo, additional, Briguori, Carlo, additional, Kuku, Kayode O., additional, Karagiannis, Alexios, additional, and Valgimigli, Marco, additional

Published
2020
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114. The legacy of ISCHEMIA

Author

Ianni, Umberto, primary, Radico, Francesco, additional, Ricci, Fabrizio, additional, Perfetti, Matteo, additional, Archilletti, Federico, additional, Renda, Giulia, additional, Maddestra, Nicola, additional, Gallina, Sabina, additional, and Zimarino, Marco, additional

Published
2020
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118. Assessment of residual thrombus burden in patients with ST‐segment elevation myocardial infarction undergoing bivalirudin versus unfractionated heparin infusion: The MATRIX (minimizing adverse hemorrhagic events by transradial access site and angioX) OCT study

Author

Garcia‐Garcia, Hector M., primary, Adamo, Marianna, additional, Soud, Mohamad, additional, Yacob, Omar, additional, Picchi, Andrea, additional, Sardella, Gennaro, additional, Frigoli, Enrico, additional, Limbruno, Ugo, additional, Rigattieri, Stefano, additional, Diletti, Roberto, additional, Boccuzzi, Giacomo, additional, Zimarino, Marco, additional, Contarini, Marco, additional, Russo, Filippo, additional, Calabrò, Paolo, additional, Andò, Giuseppe, additional, Varbella, Ferdinando, additional, Garducci, Stefano, additional, Palmieri, Cataldo, additional, Briguori, Carlo, additional, Karagiannis, Alexios, additional, and Valgimigli, Marco, additional

Published
2019
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119. Assessment of residual thrombus burden in patients with ST‐segment elevation myocardial infarction undergoing bivalirudin versus unfractionated heparin infusion: The MATRIX (minimizing adverse hemorrhagic events by transradial access site and angioX) OCT study

Author

Garcia‐Garcia, Hector M., Adamo, Marianna, Soud, Mohamad, Yacob, Omar, Picchi, Andrea, Sardella, Gennaro, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabrò, Paolo, Andò, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, and Briguori, Carlo

Published
2020
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120. Comparison of intra-procedural vs. post-stenting prolonged bivalirudin infusion for residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing: the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and angioX) OCT study

Author

Garcia-Garcia, Hector M, Picchi, Andrea, Sardella, Gennaro, Adamo, Marianna, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabro', Paolo, Andò, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, Briguori, Carlo, Kuku, Kayode O, and Rothenbühler, Martina

Subjects
THROMBOSIS prevention, BIVALIRUDIN, COMPARATIVE studies, INTRAOPERATIVE care, MEDICAL cooperation, MYOCARDIAL infarction, POSTOPERATIVE care, RESEARCH, STATISTICAL sampling, OPTICAL coherence tomography, RANDOMIZED controlled trials, TREATMENT effectiveness, DESCRIPTIVE statistics, PERCUTANEOUS coronary intervention
Abstract

Aims To compare prolonged bivalirudin infusion vs. an intra-procedural only bivalirudin infusion administration in subjects with ST-segment elevation myocardial infarction (STEMI) regarding residual stent strut thrombosis. Methods and results Multivessel STEMI patients undergoing primary percutaneous coronary intervention (PPCI) and scheduled for a staged percutaneous coronary intervention (PCI) before hospital discharge were selected among those allocated to either prolonged bivalirudin or intra-procedural only bivalirudin infusion in the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and angioX) Treatment-Duration study. Optical coherence tomography (OCT) of the infarct-related artery was performed at the end of PPCI and 4–5 days thereafter during staged intervention. The predefined endpoint was the percentage difference in the number of stent cross-sections with a thrombotic area >5% at the end of PPCI and at the time of staged PCI (ΔThCS). Between September 2013 and November 2015, 137 were randomized to either intra-procedural only bivalirudin infusion (N  = 64) or prolonged bivalirudin (N  = 73) at 16 European sites. Mean stent area, minimum lumen area, percentage of malapposed struts, and mean percent thrombotic area were comparable after index or staged PCI. The difference in the proportion of frames with percent thrombotic area >5% (ΔTh > 5%) were −7.7 (−22.1 to 5.1) in the intra-procedural bivalirudin infusion group and −8.8 (−23.1 to 2.6) in the prolonged infusion group (P  = 0.994). Time from index to follow-up OCT imaging and the infarct vessel artery did not affect this OCT-based endpoint. Conclusion A strategy of prolonged bivalirudin infusion after PPCI did not reduce residual stent strut thrombosis when compared with intra-procedural only bivalirudin infusion administration (funded by The Medicines Company and Terumo; MATRIX ClinicalTrials.gov number, NCT01433627). [ABSTRACT FROM AUTHOR]

Published
2019
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121. Factors for heterogeneous outcomes of angina and myocardial ischemia without obstructive coronary atherosclerosis.

Author

Radico, Francesco, Di Castelnuovo, Augusto, Aimo, Alberto, Zimarino, Marco, Knuuti, Juhani, Rossi, Serena, Pastormerlo, Luigi Emilio, Zyw, Luc, Orsini, Enrico, Iacoviello, Licia, Neglia, Danilo, Emdin, Michele, de Gaetano, Giovanni, and De Caterina, Raffaele

Subjects
MYOCARDIAL ischemia, CORONARY artery disease, ANGINA pectoris, ATHEROSCLEROSIS, MUCOCUTANEOUS lymph node syndrome, CORONARY angiography, MYOCARDIAL infarction
Abstract

Background and objectives: The absence of obstructive coronary artery disease (CAD) in patients with angina is common, but its prognosis is debated. We investigated outcomes of such patients to identify predictors of cardiovascular events. Methods: We selected 1014 patients with angina, evidence of myocardial ischemia at the electrocardiogram (ECG) exercise test or imaging stress tests, and nonobstructive CAD (absence of lumen diameter reduction ≥50%) at coronary angiography between 1999 and 2015. Note that, 1905 age‐ and risk factors‐matched asymptomatic subjects served as "real‐world" comparators. The primary endpoint was the occurrence of all‐cause death or myocardial infarction. Results: At 6‐years median follow‐up (interquartile range, 3–9 years), the primary endpoint occurred in 53 patients (5.5%, 0.92/100 person‐years). Besides similar event rates compared with asymptomatic subjects (hazard ratio [HR] 0.85, 95% confidence interval [CI] 0.62–1.15, p = 0.28), the index population showed a very heterogeneous prognosis. Patients with nonobstructive CAD (HR 1.85, 95% CI 1.02–3.37, p = 0.04, compared with "normal" coronary arteries) and ischemia at imaging tests (HR 2.11, 95% CI 1.07–4.14, p = 0.03, compared with ischemia detected only at the ECG exercise test) were at higher risk and those with both these components showing even >10‐fold event rates as compared with the absence of both. Three‐hundred and twenty‐five patients (34%) continued to experience angina, 69 (7.2%) underwent repeat coronary angiography, and 14 (1.5%) had consequent coronary revascularization for atherosclerosis progression. Conclusion: Apart from the impaired quality of life, angina without obstructive CAD has an overall benign but very heterogeneous prognosis. Nonobstructive CAD and myocardial ischemia at imaging tests both confer a higher risk. [ABSTRACT FROM AUTHOR]

Published
2022
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122. OCT Appraisal of Residual Thrombus Burden in Patients With STEMI Undergoing Intraprocedural Versus Post-Stenting Prolonged Bivalirudin Infusion: The MATRIX OCT Study

Author

Picchi, Andrea, Garcia-Garcia, Hector M, Sardella, Gennaro, Adamo, Marianna, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabro, Paolo, Andò, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, Briguori, Carlo, Kuku, Kayode O, Rothenbühler, Martina, Karagiannis, Alexios, Valgimigli, Marco, Picchi, A., Garcia-Garcia, H. M., Sardella, G., Adamo, M., Frigoli, E., Limbruno, U., Rigattieri, S., Diletti, R., Boccuzzi, G., Zimarino, M., Contarini, M., Russo, F., Calabro, P., Ando, G., Varbella, F., Garducci, S., Palmieri, C., Briguori, C., Kuku, K. O., Rothenbuhler, M., Karagiannis, A., and Valgimigli, M.

Subjects
Hirudin, Coronary Thrombosi, Time Factors, Time Factor, Antithrombin, Coronary Thrombosis, Predictive Value of Test, Recombinant Protein, Hirudins, Antithrombins, Drug Administration Schedule, Peptide Fragments, Recombinant Proteins, Percutaneous Coronary Intervention, Treatment Outcome, Peptide Fragment, Predictive Value of Tests, Stent, Humans, ST Elevation Myocardial Infarction, Infusions, Parenteral, Stents, 610 Medicine & health, Tomography, Optical Coherence, Human
Published
2019

131. Impact of sex on comparative outcomes of bivalirudin versus unfractionated heparin in patients with acute coronary syndromes undergoing invasive management: a pre-specified analysis of the MATRIX trial

Author

Gargiulo, Giuseppe, primary, da Costa, Bruno R., additional, Frigoli, Enrico, additional, Palmieri, Cataldo, additional, Nazzaro, Marco Stefano, additional, Falcone, Camillo, additional, Liso, Armando, additional, Vigna, Carlo, additional, Abate, Fabio, additional, Comeglio, Marco, additional, Diletti, Roberto, additional, Gabrielli, Gabriele, additional, Di Lorenzo, Emilio, additional, Mazzarotto, Pietro, additional, Zimarino, Marco, additional, Moretti, Claudio, additional, Colombo, Antonio, additional, Penzo, Carlo, additional, Pasquetto, Giampaolo, additional, Brugaletta, Salvatore, additional, Ferrari, Fabio, additional, Casu, Gavino, additional, Guiducci, Vincenzo, additional, Dellavalle, Antonio, additional, Liistro, Francesco, additional, Mauro, Ciro, additional, van't Hof, Arnoud W.J., additional, Omerovic, Elmir, additional, Curello, Salvatore, additional, de la Torre Hernandez, Jose Maria, additional, De Servi, Stefano, additional, Belloni, Flavia, additional, Windecker, Stephan, additional, and Valgimigli, Marco, additional

Published
2019
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132. OCT Appraisal of Residual Thrombus Burden in Patients With STEMI Undergoing Intraprocedural Versus Post-Stenting Prolonged Bivalirudin Infusion

Author

Picchi, Andrea, primary, Garcia-Garcia, Hector M., additional, Sardella, Gennaro, additional, Adamo, Marianna, additional, Frigoli, Enrico, additional, Limbruno, Ugo, additional, Rigattieri, Stefano, additional, Diletti, Roberto, additional, Boccuzzi, Giacomo, additional, Zimarino, Marco, additional, Contarini, Marco, additional, Russo, Filippo, additional, Calabro, Paolo, additional, Andò, Giuseppe, additional, Varbella, Ferdinando, additional, Garducci, Stefano, additional, Palmieri, Cataldo, additional, Briguori, Carlo, additional, Kuku, Kayode O., additional, Rothenbühler, Martina, additional, Karagiannis, Alexios, additional, and Valgimigli, Marco, additional

Published
2019
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133. Mid-term outcomes after percutaneous interventions in coronary bifurcations

Author

Zimarino, Marco, primary, Briguori, Carlo, additional, Amat-Santos, Ignacio J., additional, Radico, Francesco, additional, Barbato, Emanuele, additional, Chieffo, Alaide, additional, Cirillo, Plinio, additional, Costa, Ricardo A., additional, Erglis, Andrejs, additional, Gamra, Habib, additional, Gil, Robert J., additional, Kanic, Vojko, additional, Kedev, Sasko A., additional, Maddestra, Nicola, additional, Nakamura, Sunao, additional, Pellicano, Mariano, additional, Petrov, Ivo, additional, Strozzi, Maja, additional, Tesorio, Tullio, additional, Vukcevic, Vladan, additional, De Caterina, Raffaele, additional, and Stankovic, Goran, additional

Published
2019
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136. IMPACT OF CLINICAL PRESENTATION, LESION COMPLEXITY, AND TREATMENT STRATEGIES ON MID-TERM OUTCOMES AFTER PERCUTANEOUS INTERVENTIONS IN CORONARY BIFURCATIONS: A RETROSPECTIVE ANALYSIS FROM THE EURO BIFURCATION CLUB REGISTRY

Author

Chieffo, Alaide, primary, Radico, Francesco, additional, Costa, Ricardo, additional, Zimarino, Marco, additional, Briguori, Carlo, additional, Amat-Santos, Ignacio, additional, Barbato, Emanuele, additional, Cirillo, Plinio, additional, Erglis, Andrejs, additional, Gamra, Habib, additional, Gill, Robert, additional, Kanic, Vojko, additional, Kedev, Sasko, additional, Maddestra, Nicola, additional, Nakamura, Sunao, additional, Pellicano, Mariano, additional, Petrov, Ivo, additional, Strozzi, Maja, additional, Tesorio, Tullio, additional, Vladan, Vukcevic, additional, and Stankovic, Goran, additional

Published
2019
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141. Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis

Author

Radico, Francesco, primary, Zimarino, Marco, additional, Fulgenzi, Fabio, additional, Ricci, Fabrizio, additional, Di Nicola, Marta, additional, Jespersen, Lasse, additional, Chang, Su Min, additional, Humphries, Karin H, additional, Marzilli, Mario, additional, and De Caterina, Raffaele, additional

Published
2018
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146. Bivalirudin or unfractionated heparin in patients with acute coronary syndromes managed invasively with and without ST elevation (MATRIX): randomised controlled trial

Author

Leonardi, Sergio, primary, Frigoli, Enrico, additional, Rothenbühler, Martina, additional, Navarese, Eliano, additional, Calabró, Paolo, additional, Bellotti, Paolo, additional, Briguori, Carlo, additional, Ferlini, Marco, additional, Cortese, Bernardo, additional, Lupi, Alessandro, additional, Lerna, Salvatore, additional, Zavallonito-Parenti, Dennis, additional, Esposito, Giovanni, additional, Tresoldi, Simone, additional, Zingarelli, Antonio, additional, Rigattieri, Stefano, additional, Palmieri, Cataldo, additional, Liso, Armando, additional, Abate, Fabio, additional, Zimarino, Marco, additional, Comeglio, Marco, additional, Gabrielli, Gabriele, additional, Chieffo, Alaide, additional, Brugaletta, Salvatore, additional, Mauro, Ciro, additional, Van Mieghem, Nicolas M, additional, Heg, Dik, additional, Jüni, Peter, additional, Windecker, Stephan, additional, and Valgimigli, Marco, additional

Published
2016
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147. ST segment/heart rate hysteresis improves the diagnostic accuracy of ECG stress test for coronary artery disease in patients with left ventricular hypertrophy

Author

Zimarino, Marco, primary, Montebello, Elena, additional, Radico, Francesco, additional, Gallina, Sabina, additional, Perfetti, Matteo, additional, Iachini Bellisarii, Francesco, additional, Severi, Silva, additional, Limbruno, Ugo, additional, Emdin, Michele, additional, and De Caterina, Raffaele, additional

Published
2016
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148. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries

Author

Agewall, Stefan, primary, Beltrame, John F., additional, Reynolds, Harmony R., additional, Niessner, Alexander, additional, Rosano, Giuseppe, additional, Caforio, Alida L. P., additional, De Caterina, Raffaele, additional, Zimarino, Marco, additional, Roffi, Marco, additional, Kjeldsen, Keld, additional, Atar, Dan, additional, Kaski, Juan C., additional, Sechtem, Udo, additional, and Tornvall, Per, additional

Published
2016
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149. The left atrial appendage: from embryology to prevention of thromboembolism

Author

Patti, Giuseppe, primary, Pengo, Vittorio, additional, Marcucci, Rossella, additional, Cirillo, Plinio, additional, Renda, Giulia, additional, Santilli, Francesca, additional, Calabrò, Paolo, additional, De Caterina, Alberto Ranieri, additional, Cavallari, Ilaria, additional, Ricottini, Elisabetta, additional, Parato, Vito Maurizio, additional, Zoppellaro, Giacomo, additional, Di Gioia, Giuseppe, additional, Sedati, Pietro, additional, Cicchitti, Vincenzo, additional, Davì, Giovanni, additional, Golia, Enrica, additional, Pariggiano, Ivana, additional, Simeone, Paola, additional, Abbate, Rosanna, additional, Prisco, Domenico, additional, Zimarino, Marco, additional, Sofi, Francesco, additional, Andreotti, Felicita, additional, and De Caterina, Raffaele, additional

Published
2016
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