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Your search keyword '"Zhao, Shizhen"' showing total 450 results
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450 results on '"Zhao, Shizhen"'

102. Molecular signatures and formation mechanisms of particulate matter (PM) water-soluble chromophores from Karachi (Pakistan) over South Asia.

Author

Tang, Jiao, Li, Jun, Zhao, Shizhen, Zhong, Guangcai, Mo, Yangzhi, Jiang, Hongxing, Jiang, Bin, Chen, Yingjun, Tang, Jianhui, Tian, Chongguo, Zong, Zheng, Syed, Jabir Hussain, Song, Jianzhong, and Zhang, Gan

Subjects
ION cyclotron resonance spectrometry, PARTICULATE matter, CHROMOPHORES, FOURIER transform spectroscopy, LIGHT absorption, FLUORESCENCE spectroscopy
Abstract

Excitation-emission matrix (EEM) fluorescence spectroscopy has been widely used to characterize chemical components of brown carbon (BrC), yet the molecular basics and formation mechanisms of chromophores decomposed by parallel factor (PARAFAC) analysis are not fully understood. Here, water-soluble organic carbon (WSOC) in aerosols from Karachi, Pakistan, were characterized with EEM spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Three PARAFAC components were identified, including two humic-like (C1 and C2), and one protein-like (C3) species. Among them, the C2 shows the longest emission maxima (~494 nm), and correlates tightly with the mass absorption efficiency at 365 nm (MAE365), the character of BrC. Molecular families associated with each of the three components were determined by Spearman correlation analysis between FT-ICR MS peaks and PARAFAC component intensities. The C1 and C2 components are associated with nitrogen-enriched compounds, despite that C2 more with higher aromaticity, higher N content, and highly oxygenated compounds. The formulas associated with C3 include fewer nitrogen-containing species, with a lower unsaturated degree and oxidation state. A dominant oxidation pathway for the formation of C1 and C2 components was suggested, notwithstanding their different precursor types. A large number of formulas associated with C2 were found to be located in the "potential BrC" region, overlapped with BrC-associated formulas, and readily correlated tightly with MAE365. This suggests that the compounds illuminating C2 may have also contributed substantially to the BrC light absorption. These findings were important for future studies using the EEM-PARAFAC method to explore the compositions, processes, and sources of atmospheric BrC. [ABSTRACT FROM AUTHOR]

Published
2023
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104. Molecular Characteristics of Organosulfur Compounds in Guangzhou, South China: Heterogeneous Secondary Reactions Drivers the Molecular Distribution

Author

Jiang, Hongxing, primary, Li, Jun, additional, Tang, Jiao, additional, Cui, Min, additional, Zhao, Shizhen, additional, Mo, Yangzhi, additional, Tian, Chongguo, additional, Zhang, Xiangyun, additional, Jiang, Bin, additional, Liao, Yuhong, additional, Chen, Yinjun, additional, and Zhang, Gan, additional

Published
2022
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105. Supplementary material to "Molecular Characteristics of Organosulfur Compounds in Guangzhou, South China: Heterogeneous Secondary Reactions Drivers the Molecular Distribution"

Author

Jiang, Hongxing, primary, Li, Jun, additional, Tang, Jiao, additional, Cui, Min, additional, Zhao, Shizhen, additional, Mo, Yangzhi, additional, Tian, Chongguo, additional, Zhang, Xiangyun, additional, Jiang, Bin, additional, Liao, Yuhong, additional, Chen, Yinjun, additional, and Zhang, Gan, additional

Published
2022
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118. Large contribution of fossil-derived components to aqueous secondary organic aerosols in China

Author

Xu, Buqing, primary, Zhang, Gan, additional, Gustafsson, Örjan, additional, Kawamura, Kimitaka, additional, Lin, Jun, additional, Andersson, August, additional, Bikkina, Srinivas, additional, Kunwar, Bhagawati, additional, Pokhrel, Ambarish, additional, Zhong, Guangcai, additional, Zhao, Shizhen, additional, Li, Jing, additional, Huang, Chen, additional, Cheng, Zhineng, additional, Zhu, Sanyuan, additional, Peng, Ping'an, additional, and Sheng, Guoying, additional

Published
2021
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130. DDT, Chlordane, and Hexachlorobenzene in the Air of the Pearl River Delta Revisited: A Tale of Source, History, and Monsoon

Author

Tian, Lele, primary, Li, Jing, additional, Zhao, Shizhen, additional, Tang, Jiao, additional, Li, Jun, additional, Guo, Hai, additional, Liu, Xin, additional, Zhong, Guangcai, additional, Xu, Yue, additional, Lin, Tian, additional, Lyv, Xiaopu, additional, Chen, Duohong, additional, Li, Kechang, additional, Shen, Jin, additional, and Zhang, Gan, additional

Published
2021
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132. Enabling Quasi-Static Reconfigurable Networks With Robust Topology Engineering

Author

Teh, Min Yee, Zhao, Shizhen, Cao, Peirui, and Bergman, Keren

Abstract

Many optical circuit switched data center networks (DCN) have been proposed in the last decade to attain higher capacity and topology reconfigurability, though commercial adoption of these architectures have been minimal. One major challenge these architectures face is the difficulty of handling uncertain traffic demands using commercial optical circuit switches (OCS) with high switching latency. Prior works have generally focused on developing fast-switching OCS prototypes to quickly react to traffic variations through frequent reconfigurations. This approach, however, adds tremendous complexity overhead to the control plane, and raises the barrier for commercial adoption of optical circuit switched data center networks. We propose COUDER, a robust topology and routing optimization framework for reconfigurable optical circuit switched data centers. COUDER co-optimizes topology and routing based on a convex set of traffic matrices, and offers strict throughput guarantees for any future traffic matrices bounded by the convex set. For the bursty traffic demands that are unbounded by the convex set, we employ a desensitization technique to reduce performance hit. This enables COUDER to generate topology and routing solutions capable of handling unexpected traffic changes without relying on frequent topology reconfigurations. Our extensive evaluations based on Facebook’s production DCN traces show that, even with daily reconfigurations which could be realized by current commercial MEMS-based OCSs from Calient Technologies, COUDER achieves about 20% lower max link utilization, and about 32% lower average hop count compared to cost-equivalent static topologies. Our work shows that adoption of reconfigurable topologies in commercial DCNs is feasible even without fast OCSs.

Published
2023
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143. Ligand-based pharmacophore modeling, virtual screening and biological evaluation to identify novel TGR5 agonists

Author

Li Xinping, Wei-Dong Chen, Yang Zhao, Wenjing Peng, Wenbo Yin, Ye Wenling, Weiguo Li, Zhao Shizhen, Yan-Dong Wang, and Le Wang

Subjects
Agonist, 0303 health sciences, Virtual screening, Nonsteroidal, Chemistry, medicine.drug_class, General Chemical Engineering, General Chemistry, Computational biology, Ligand (biochemistry), G protein-coupled bile acid receptor, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Pharmacophore, 030304 developmental biology, Biological evaluation
Abstract

Takeda G-protein-coupled receptor 5 (TGR5) is emerging as an important and promising target for the development of anti-diabetic drugs. To understand the structural characteristics of TGR5 agonists, the common feature pharmacophore models were generated and molecular docking was performed. The ligand-based virtual screening combined with pharmacophore mapping and molecular docking was performed to identify novel nonsteroidal TGR5 agonists. Finally, 20 compounds were screened for in vitro TGR5 agonistic activity assay, and results showed most compounds exhibiting TGR5 agonistic activity at 40 μM. Among these compounds, V12 and V14 displayed obvious TGR5 agonist activity, with the EC50 values of 19.5 μM and 7.7 μM, respectively. Compounds V12 and V14 could be considered potential TGR5 agonist candidates and also may be used as initial hits for developing novel TGR5 agonists.

Published
2020

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