Search

The rapid variation of atmospheric water vapor is important for a regional hydrologic cycle and climate change. However, it is rarely investigated in China, due to the lack of a precipitable water vapor (PWV) dataset with high temporal resolution. Therefore, this study focuses on the generation of an hourly PWV dataset using Global Navigation Satellite System (GNSS) observations derived from the Crustal Movement Observation Network of China. The zenith total delay parameters estimated by GAMIT/GLOBK software are used and validated with an average root mean square (RMS) error of 4–5 mm. The pressure (P) and temperature (T) parameters used to calculate the zenith hydrostatic delay (ZHD) and weighted average temperature of atmospheric water vapor (Tm) are derived from the fifth-generation reanalysis dataset of the European Centre for Medium-Range Weather Forecasting (ECMWF ERA5) products. The values of P and T at the GNSS stations are obtained by interpolation in the horizontal and vertical directions using empirical formulas. Tm is calculated at the GNSS stations using the improved global pressure and temperature 2 wet (IGPT2w) model in China with an RMS of 3.32 K. The interpolated P and T are validated by interpolating the grid-based ERA5 data into radiosonde stations. The average RMS and bias of P and T in China are 2.71/−1.11 hPa and 1.88/−0.51 K, respectively. Therefore, the error in PWV with a theoretical RMS of 1.85 mm over the period of 2011–2017 in China can be obtained. Finally, the hourly PWV dataset in China is generated and the practical accuracy of the generated PWV dataset is validated using the corresponding AERONET and radiosonde data at specific stations. Numerical results reveal that the average RMS values of the PWV dataset in the four geographical regions of China are less than 3 mm. A case analysis of the PWV diurnal variations as a response to the EI Niño event of 2015–2016 is performed. Results indicate the capability of the hourly PWV dataset of monitoring the rapid water vapor changes in China. [ABSTRACT FROM AUTHOR]

Typhoons can be serious natural disasters for the sustainability and development of society. The development of a typhoon usually involves a pre-existing weather disturbance, warm tropical oceans, and a large amount of moisture. This implies that a large variation in the atmospheric water vapor over the path of a typhoon can be used to study the characteristics of the typhoon. This is the reason that the variation in precipitable water vapor (PWV) is often used to capture the signature of a typhoon in meteorology. This study investigates the usability of real-time PWV retrieved from global navigation satellite systems (GNSS) for typhoons' characterizations, and especially, the following aspects were investigated: (1) The correlation between PWV and atmospheric parameters including pressure, temperature, precipitation, and wind speed; (2) water vapor transportation during a typhoon period; and (3) the correlation between the movement of a typhoon and the transportation of water vapor. The case study selected for this research was Super Typhoon Mangkhut that occurred in mid-September 2018 in Hong Kong. The PWV time series were obtained from a conversion of GNSS-derived zenith total delays (ZTDs) using observations at 10 stations selected from the Hong Kong GNSS continuously operating reference stations (CORS) network, which are also located along the path of the typhoon. The Bernese GNSS Software (ver. 5.2) was used to obtain the ZTDs; and the root mean square (RMS) of the differences between the GNSS-ZTDs and International GNSS Service post-processed ZTDs time series was less than 8 mm. The RMS of the differences between the GNSS-PWVs (i.e., the ZTDs converted PWVs) and radiosonde-derived PWVs (RS-PWVs) time series was less than 2 mm. The changes in PWV reflect the variation in wind speed during the typhoon period to a certain degree, and their correlation coefficient was 0.76, meaning a significant positive correlation. In addition, a new approach was proposed to estimate the direction and speed of a typhoon's movement using the time difference of PWV arrival at different sites. The direction and speed estimated agreed well with the ones published by the China Meteorological Administration. These results suggest that GNSS-derived PWV has a great potential for the monitoring and even prediction of typhoon events, especially for near real-time warnings. [ABSTRACT FROM AUTHOR]

Metastasis is the leading cause for the high mortality of lung cancer, however, effective anti-metastatic drugs are still limited. Here it is reported that the RNA-binding protein RBMS1 is positively associated with increased lymph node metastasis in non-small cell lung cancer (NSCLC). Depletion of RBMS1 suppresses cancer cell migration and invasion in vitro and inhibits cancer cell metastasis in vivo. Mechanistically, RBMS1 interacts with YTHDF1 to promote the translation of S100P, thereby accelerating NSCLC cell metastasis. The RRM2 motif of RBMS1 and the YTH domain of YTHDF1 are required for the binding of RBMS1 and YTHDF1. RBMS1 ablation inhibits the translation of S100P and suppresses tumor metastasis. Targeting RBMS1 with NTP, a small molecular chemical inhibitor of RBMS1, attenuates tumor metastasis in a mouse lung metastasis model. Correlation studies in lung cancer patients further validate the clinical relevance of the findings. Collectively, the study provides insight into the molecular mechanism by which RBMS1 promotes NSCLC metastasis and offers a therapeutic strategy for metastatic NSCLC., (© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)