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Oxidative stress is believed to be one of the primary causes in ischemic stroke injury, and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is the most important endogenous antioxidative stress damage pathway. Cottonseed oil (CSO), which is used mostly as a solvent for lipid-soluble drugs, has been shown to exert antioxidative effects against peripheral tissue injury. However, the effects and mechanisms of CSO on ischemic stroke-induced oxidative stress injury and the Nrf2 signaling pathway remain largely unknown. In this study, we investigated the potential of CSO in regulating oxidative stress injury induced by middle cerebral artery occlusion and reperfusion (MCAO-R), or oxygen and glucose deprivation and reperfusion (OGD-R). We found that 1.3 mL/kg CSO treatment of male rats with a subcutaneous injection once every other day for 3 weeks significantly improved neurological deficit; reduced infarction volume; alleviated neuronal injuries; reduced the content of ROS and MDA; increased the activity of SOD, GSH, and GSH-PX; and markedly increased the expression of Nrf2. Furthermore, treatment with 10−9 μL/mL CSO to a neuron cell line (HT-22) for 24 h significantly increased cell viability and decreased cell apoptosis after OGD-R injury; significantly reduced the levels of ROS and MDA; increased the activity of SOD, GSH, and GSH-PX; and induced an increase in Nrf2 nuclear translocation. Based on our findings, we conclude that CSO treatment alleviates ischemic stroke injury-induced oxidative stress via activating the Nrf2 signaling pathway, highlighting the potential that CSO has as a therapeutic for ischemic strokes.

In order to achieve rapid and effective analysis of praziquantel and pymetrozine residues in food, a new magnetic solid phase extraction (m-SPE) material based on GO and ZIF-67 was synthesized. Because the release of ZIF and GO materials may lead to secondary environmental pollution and their separation from solutions is difficult, ZIF-67 loaded on sheet-like MGO@PDA, a magnetic porous nano-composite, was fabricated by a convenient method at room temperature. The poly-dopamine (PDA) layer can improve the hydrophilicity of the material. The resultant MGO@PDA@ZIF-67 preserved the properties of ZIF-67 and MGO. The adsorbent material was characterized by XRD, VSM, TEM, SEM, TGA, XPS and FTIR experiments. An m-SPE technique was developed to selectively enrich two pyridine ring insecticides (praziquantel and pymetrozine) using high performance liquid chromatography (HPLC). The adsorption mechanism was investigated. Results showed that the maximum adsorption capacities of the new material for praziquantel and pymetrozine are 22.68 and 24.27 mg g−1, respectively. The method was successfully applied to the analysis of praziquantel and pymetrozine in vegetable samples with satisfactory recoveries (92.3%–102.8%) and precisions. Due to the advantages of easy preparation, high efficiency, and renewability, the prepared hydrophilic magnetic porous nano-composite is an excellent candidate for adsorption and separation and provides a promising magnetic ZIF-67 material for multi-component system separation.

As wind farms grow in number and size worldwide, it is important that their potential impacts on the environment are studied and understood. The Fitch parameterization implemented in the Weather Research and Forecasting (WRF) Model since version 3.3 is a widely used tool today to study such impacts. We identified two important issues related to the way the added turbulent kinetic energy (TKE) generated by a wind farm is treated in the WRF Model with the Fitch parameterization. The first issue is a simple “bug” in the WRF code, and the second issue is the excessive value of a coefficient, called CTKE, that relates TKE to the turbine electromechanical losses. These two issues directly affect the way that a wind farm wake evolves, and they impact properties like near-surface temperature and wind speed at the wind farm as well as behind it in the wake. We provide a bug fix and a revised value of CTKE that is one-quarter of the original value. This 0.25 correction factor is empirical; future studies should examine its dependence on parameters such as atmospheric stability, grid resolution, and wind farm layout. We present the results obtained with the Fitch parameterization in the WRF Model for a single turbine with and without the bug fix and the corrected CTKE and compare them with high-fidelity large-eddy simulations. These two issues have not been discovered before because they interact with one another in such a way that their combined effect is a somewhat realistic vertical TKE profile at the wind farm and a realistic wind speed deficit in the wake. All WRF simulations that used the Fitch wind farm parameterization are affected, and their conclusions may need to be revisited.

To improve the flame retardant and anti-dripping property of polyamide fabric, Graphene oxide (GO), Melamine and TAC（Triallyl cyanurate） were used as finishing agents to modify polyamide fabric by ...

Brain edema is a grave complication of brain ischemia and is the main cause of herniation and death. Although astrocytic swelling is the main contributor to cytotoxic edema, the molecular mechanism involved in this process remains elusive. N‐myc downstream‐regulated gene 2 (NDRG2), a well‐studied tumor suppressor gene, is mainly expressed in astrocytes in mammalian brains. Here, we found that NDRG2 deficiency leads to worsened cerebral edema, imbalanced Na+ transfer, and astrocyte swelling after ischemia. We also found that NDRG2 deletion in astrocytes dramatically changed the expression and distribution of aquaporin‐4 and Na+‐K+‐ATPase β1, which are strongly associated with cell polarity, in the ischemic brain. Brain edema and astrocyte swelling were significantly alleviated by rescuing the expression of astrocytic Na+‐K+‐ATPase β1 in NDRG2‐knockout mouse brains. In addition, the upregulation of astrocytic NDRG2 by lentiviral constructs notably attenuated brain edema, astrocytic swelling, and blood–brain barrier destruction. Our results indicate a particular role of NDRG2 in maintaining astrocytic polarization to facilitate Na+ and water transfer balance and to protect the brain from ischemic edema. These findings provide insight into NDRG2 as a therapeutic target in cerebral edema., Main Points NDRG2‐KO mice were susceptible to stroke‐induced brain edema and astrocytic swelling.NDRG2 deficiency dramatically changed astrocytic morphology and polarity.NDRG2 may serve as a potential target for ischemic brain edema intervention.

17β-Estradiol (estradiol or E2) is a steroid hormone that has been broadly applied as a neuroprotective therapy for a variety of neurodegenerative and cerebrovascular disorders such as ischemic stroke, Alzheimer's disease, and Parkinson's disease. Several laboratory and clinical studies have reported that Estrogen Replacement Therapy (ERT) had no effect against these diseases in elderly postmenopausal women, and at worst, increased their risk of onset and mortality. This review focuses on the growing body of data from in vitro and animal models characterizing the potential underlying mechanisms and signaling pathways that govern successful neuroprotection by ERT, including the roles of E2 receptors in mediating neuroprotection, E2 genomic regulation of apoptosis- related pathways, membrane-bound receptor-mediated non-genomic signaling pathways, and the antioxidant mechanisms of E2. Also discussed is the current evidence for a critical period of effective treatment with estrogen following natural or surgical menopause and the outcomes of E2 administration within an advantageous time period. The known mechanisms governing the duration of the critical period include depletion of E2 receptors, the switch to a ketogenic metabolic profile by neuronal mitochondria, and a decrease in acetylcholine that accompanies E2 deficiency. Also the major clinical trials and observational studies concerning postmenopausal Hormone Therapy (HT) are summarized to compare their outcomes with respect to neurological disease and discuss their relevance to the critical period hypothesis. Finally, potential controversies and future directions for this field are discussed throughout the review.

Postmenopausal women experience a higher risk for neurodegenerative diseases, including cognitive impairment and ischemic stroke. Many preclinical studies have indicated that estrogen replacement therapy (ERT) may provide protective effects against these neurological diseases. However, the results of Women’s Health Initiative (WHI) studies have led to the proposal of “critical period hypothesis,” which states that there is a precise window of opportunity for administering beneficial hormone therapy following menopause. However, the underlying molecular mechanisms require further characterization. Here, we explored the effects of ERT on cognition decline and global cerebral ischemia (GCI)-induced hippocampal neuronal damage in mice that had experienced both short-term (ovariectomized (OVX) 1 week) and long-term (OVX 10 weeks) estrogen deprivation. We also further explored the concentration of 17β-estradiol (E2) in the circulation and hippocampus and the expression of aromatase and estrogen receptors (ERα, ERα-Ser118, and ERβ). We found that the neuroprotective effectiveness of ERT against hippocampus damage exhibited in OVX1w mice was totally absent in OVX10w mice. Interestingly, the concentration of hippocampal E2 was irreversibly reduced in OVX10w mice, which was related to the decrease of aromatase expression in the hippocampus. In addition, long-term estrogen deprivation (LTED) led to a decrease in estrogen receptor proteins in the hippocampus. Thus, we concluded that the loss of ERT neuroprotection against hippocampus injury in LTED mice was related to the reduction in hippocampus E2 production and estrogen receptor degradation. These results provide several intervention targets to restore the effectiveness of ERT neuroprotection in elderly post-menopausal women.

Zero liquid discharge (ZLD) treatment and reuse equipment of high salinity wastewater in coal-chemical industry often occur in various types of blockage problems because of high salt content, affecting the long-term stability of the device. In this study, the effects of solution temperature, steel, reaction time and wall roughness on fouling were investigated. The changes in the contents of fouling and fouling substances were qualitatively and quantitatively analyzed by XRD and EDS respectively, and the formation of scale was observed by SEM. The results show that with temperature increasing, Q235 steel is the most difficult to scale. Scaling rate of all salt scales reaches a maximum after 12 h, and the fouling rate decreases significantly from 12 to 48 h. It gradually stabilizes at 48 to 96 h. With the roughness increasing, the thickness of fouling layer increases, and a linear relationship is presented for 1 to 10 h. By comparing actual and simulated wastewater scaling rates, the relationship between actual and simulated wastewater scaling rates is y = ax−0.494. The composition of the scale was analyzed, calcium carbonate is the main product and increases with fouling time. Based on the above-mentioned results combining literatures, the hybrid prediction model with calcium carbonate as the main product is put forward. It is discussed microscopically that calcium carbonate is converted from aragonite and vaterite in a thermodynamically metastable state to calcite in a thermodynamically stable state.

A new restricted access material (RAM) based on magnetic graphene oxide (MGO) and a temperature-response polymer brush was developed and used as an adsorbent for the magnetic solid-phase extraction (MSPE) of malachite green (MG). The adsorption and desorption of MG could be achieved on the obtained smart material only through changing the temperature of the solution. At 20 °C, lower than the lower critical solution temperature (LCST) of poly (N-isopropylacrylamide) (PNIPAAM), the temperature-response polymer chains are swollen and are in a hydrophilic state, which can improve mass transfer and binding capacity, and further enhance recognition capability and extraction efficiency for MG. When the temperature is above the LCST, the adsorbent shows hydrophilic to hydrophobic surface property alterations, leading to a gradually weakening interaction between MG and the adsorbent material, so the captured MG molecules were released. The smart material and aqueous solution achieve separation using a magnet within 2 min. The main parameters affecting the extraction efficiency were optimized. An effective analytical method for MG was developed by combining with a UV-Vis spectrophotometer. In real sample analysis, the average recoveries with their respective relative standard deviation (RSD%) for crucian and green shrimp were 79.7–90.1 (3.8–5.3%) and 73.6–81.2 (3.7–4.3%), respectively. It indicated that the new method can be applied in the determination of MG in complex real samples.

In response to a series of national strategic guidelines for green and sustainable development, recycled concrete is used as a recyclable resource. First, the mechanical properties, workability, and durability of recycled concrete are briefly introduced, and the benefit and necessities of research on recycled concrete are described from environmental, economic, and social perspectives. Second, the mixing method and molding process of recycled concrete are described in detail, and the influence of vibration molding and compression molding on the performance of recycled concrete is analyzed. It is found that the compressive strength first increases and then decreases with the increase of molding pressure. In addition, porosity decreases as molding pressure build-up. Therefore, it is recommended that the molding pressure of recycled concrete be generally controlled between 600 and 800 N. Then, the influence of the water-cement ratio on recycled concrete’s fluidity and mechanical properties is discussed. It is found that with the increase of the water-cement ratio, the compressive strength first increases and then decreases and the optimum water-cement ratio is proposed to be 0.2. Finally, the application status and problems of recycled concrete in road engineering are briefly described, and relevant suggestions for construction technology are put forward. Based on the fire safety and reliability requirements of concrete structures, the performance of high-performance concrete structures after fire can be restored to the initial level or even improved through the processes and measures of building structure design, repair, and reinforcement; the strength and crack healing of high-performance concrete after fire can be gradually restored by applying or soaking repair agent and water curing; the recovery of pH value of concrete after fire and the reduction of carbonation depth can be realized by using electrochemical realkalization technology; using carbon fiber to strengthen the components after fire can restore the bearing capacity, but the degree of stiffness recovery is low; and beam side steel plate reinforcement and steel bonding reinforcement can realize the recoverability of bearing capacity, stiffness, and ductility of members after fire.

Metabolic dysregulation and disruption of immune homeostasis have been widely associated with perioperative complications including perioperative ischemic stroke. Although immunometabolite S-2-hydroxyglutarate (S-2HG) is an emerging regulator of immune cells and thus triggers the immune response, it is unclear whether and how S-2HG elicits perioperative ischemic brain injury and exacerbates post-stroke cognitive dysfunction.Perioperative ischemic stroke was induced by transient middle cerebral artery occlusion for 60 min in C57BL/6 mice 1 day after ileocecal resection. CD8The perioperative stroke mice exhibit more severe cerebral ischemic injury and neurological dysfunction than the stroke-only mice. CD8Our study establishes that S-2HG signaling-mediated activation and neurotoxicity of CD8

Growing evidence indicates that estrogen plays a pivotal role in neuroprotection against cerebral ischemia, but the molecular mechanism of this protection is still elusive. N-myc downstream‐regulated gene 2 (Ndrg2), an estrogen-targeted gene, has been shown to exert neuroprotective effects against cerebral ischemia in male mice. However, the role of Ndrg2 in the neuroprotective effect of estrogen remains unknown. In this study, we first detected NDRG2 expression levels in the cortex and striatum in both female and male mice with western blot analyses. We then detected cerebral ischemic injury by constructing middle cerebral artery occlusion and reperfusion (MCAO-R) models in Ndrg2 knockout or conditional knockdown female mice. We further implemented estrogen, ERα or ERβ agonist replacement in the ovariectomized (OVX) Ndrg2 knockouts or conditional knockdowns female mice, then tested for NDRG2 expression, glial fibrillary acidic protein (GFAP) expression, and extent of cerebral ischemic injury. We found that NDRG2 expression was significantly higher in female than in male mice in both the cortex and striatum. Ndrg2 knockouts and conditional knockdowns showed significantly aggravated cerebral ischemic injury in female mice. Estrogen and ERβ replacement treatment (DPN) led to NDRG2 upregulation in both the cortex and striatum of OVX mice. Estrogen and DPN also led to GFAP upregulation in OVX mice. However, the effect of estrogen and DPN in activating astrocytes was lost in Ndrg2 knockouts OVX mice and primary cultured astrocytes, but partially retained in conditional knockdowns OVX mice. Most importantly, we found that the neuroprotective effects of E2 and DPN against cerebral ischemic injury were lost in Ndrg2 knockouts OVX mice but partially retained in conditional knockdowns OVX mice. These findings demonstrate that estrogen alleviated cerebral ischemic injury via ERβ upregulation of Ndrg2, which could activate astrocytes, indicating that Ndrg2 is a critical mediator of E2-induced neuroprotection against cerebral ischemic injury.

To envaluate the effect of public cardiopulmonary resuscitation (CPR) training in Ningnan Mountain area.Using the method of convenient sampling, 775 people in Ningnan Mountain area were investigated about CPR and first aid knowledge by questionnaire from January to December 2019. The awareness rate of CPR, operation score, and operation qualification rate of the public before and after CPR training in the primary trauma treatment (PTC) mode were observed.After PTC training, the public's CPR knowledge score, operation score and operation qualification rate, in terms of first aid telephone, consciousness judgment method, identification of respiratory arrest, artificial respiration implementation method, effective CPR indication and extrathoracic cardiac compression position were significantly improved [first aid telephone score: 82.68±8.54 vs. 60.25±10.38, consciousness judgment method score: 79.46±10.82 vs. 58.35±9.26, identification of respiratory arrest score: 80.85±9.64 vs. 59.26±11.45, artificial respiration implementation method score: 81.54±9.48 vs. 56.47±10.54, extrathoracic cardiac compression site score: 80.35±10.48 vs. 59.56±9.85, effective indication of CPR score: 81.02±9.45 vs. 58.21±8.69, operation assessment score: 60.25±10.45 vs. 50.38±9.68, operation assessment qualified rate: 60.39% (468/775) vs. 12.13% (94/775), all P0.05].PTC mode is helpful to improve the effect of public CPR training, which is worthy of clinical promotion.

Spent methanol-to-propylene (MTP) catalysts have a large specific surface area and high porosity but are usually disposed of in landfills directly, and recycling has rarely been reported. In this study, the spent MTP catalyst was moderately dealuminized with organic acids and etched with alkali solvent to increase its specific surface area, further silanized by octyl triethoxy silane (OTS). A novel superhydrophobic adsorbent covered with -Si(CH2)7CH3 groups was obtained. The characterization of XRD, SEM, FTIR and XPS shows that the adsorbent maintains a typical ZSM-5 zeolite structure, and the -Si(CH2)7CH3 group is successfully grafted into the sample, not only on the surface but also in some pore space. Taking high chemical oxygen demand (COD) wastewater as the object, the influence of contract time and pH temperature on COD removal was investigated. The removal process could be better depicted by the Langmuir isotherm model and the pseudo second-order dynamic model; moreover, the results of the thermodynamic study (∆G is −79.35 kJ/mol, ∆S is 423.68 J/mol∙K, and ∆H is 46.91 kJ/mol) show that the adsorption was a spontaneous and endothermic process. These findings indicate that the modified spent MTP catalyst has potential application for the removal of COD from wastewater.

Photothermal bimorph actuators have attracted considerable attention in intelligent devices because of their cordless control and lightweight and easy preparation. However, current photothermal bimorph actuators are mostly based on films or papers driven by near-infrared sources, which are deficient in flexibility and adaptability, restricting their potential in wearable applications. Herein, a bimorph textile actuator that can be scalably fabricated with a traditional textile route and autonomously triggered by sunlight is reported. The active layer and passive layer of the bimorph are constructed by polypropylene tape and a MXene-modified polyamide filament. Because of the opposite thermal expansion and MXene-enhanced photothermal efficiency (>260%) of the bimorph, the textile actuator presents effective deformation (1.38 cm–1) under low sunlight power (100 mW/cm2). This work provides a new pathway for wearable sunlight-triggered actuators and finds attractive applications for smart textiles.

The single, double, triple, and quadruple Auger decays of ${\mathrm{Ar}}^{+}(2{s}^{\ensuremath{-}1})$ are studied, based on many-body perturbation theory. The level-to-level investigation indicates that the double Auger primarily comes from the cascade process involving the Coster-Kronig decay. Moreover, the complex triple Auger and quadruple Auger decay are expressed by the multistep approach, i.e., the combination of cascade and direct processes. On the other hand, by employing the separate orbital sets for optimizing the single-electron wave functions, our ion yield ratios (${\mathrm{Ar}}^{2+}:{\mathrm{Ar}}^{3+}:{\mathrm{Ar}}^{4+}:{\mathrm{Ar}}^{5+}=3.5:88.7:7.5:0.26$) agree quite well with the recent experimental data (3:89:8:0.3) [Lablanquie et al., Phys. Chem. Chem. Phys. 13, 18355 (2011)]. Moreover, the single, double, and triple Auger spectra, as well as lifetime, are all in accord with the measurements of Lablanquie et al.

Flexible textile-based supercapacitors (SCs) have attracted a lot of attention, with the artificial intelligence technology and smart wearable electronic textiles developing rapidly. However, energy-storage performance of common textile-based SCs is always restricted with the low-dimensional substrates (i.e., one-dimensional fibers or two-dimensional fabrics), and hence flexible textile-based SCs with multifarious hierarchical substrates are highly desired. Herein, a multidimensional hierarchical fabric electrode model with a bionic fiber microarray structure has been designed, inspired by the "grasp effect" of the sophisticated arrangement structures of hedgehog spines, and the bionic assembled SCs exhibit an enhanced specific areal capacitance (245.5 mF/cm

Forest edges have significant impacts on flow dynamics and mass exchange across the forest–atmosphere interface. A better understanding of edge flows and scalar transport has implications for locating and interpreting eddy-covariance flux measurements over finite-size forests with edges. Here the large-eddy simulation module within the Weather Research and Forecasting model is deployed to study the influence of forest edges on flow dynamics and scalar transport for a range of vertical distributions of foliage and scalar sources/sinks. For plant canopies with a relatively dense trunk space, a strong in-canopy flow convergence develops near the leading edge, which dominates the flow dynamics and leads to distinct scalar concentration and flux patterns not only across edges but also across the forest–atmosphere interface for sources near the ground and lower part of the canopy. For plant canopies with a deep, sparse trunk space, a strong and long sub-canopy jet develops, leading to simpler features in flow dynamics and scalar transfer. A real case with scalar sources/sink distributions as simulated by a newly developed multiple-layer canopy module produces even more complex scalar concentration and flux patterns. The budget equations for scalars are also analyzed to quantify the contributions of different terms to scalar fluxes. Our results demonstrate that both the scalar source distributions and canopy structures should be considered when eddy-covariance flux measurements are made over finite-size forests with edges.

Since goaf water can cause water inrush, collapse or other severe geological hazards in coal mining, its detection has become a significant issue. As the grounded electrical source airborne transient electromagnetic (GREATEM) system can provide considerable prospecting depth, lateral resolution, and high detection efficiency, the method may be suitable for goaf water detection. To verify the feasibility, a field electromagnetic survey over Qinshui coal mine (Shanxi province, China) was conducted, and the system was used to detect the geoelectric characteristics of goaf water. After data acquisition, data processing, and apparent resistivity calculation, the resistivity profile of survey area is clearly presented, which is consistent with the information provided by Shanxi Coal Geology Geophysical Surveying Exploration Institute, China. The result shows that the application of GREATEM system is an effective technique for resistivity detection of goaf water, and can reduce the risks in coal mining.

Forest canopies play a critical role in affecting momentum and scalar transfer. Although there have been recent advances in numerical simulations of turbulent flows and scalar transfer across plant canopies and the atmosphere interface, few models have incorporated all important physical and physiological processes in subcanopy layers. Here we describe and evaluate an advanced multiple‐layer canopy module (MCANOPY), which is developed based largely on the Community Land Model version 4.5 and then coupled with the Weather Research and Forecasting model with large‐eddy simulations (WRF‐LES). The MCANOPY includes a suite of subcanopy processes, including radiation transfer, photosynthesis, canopy layer energy balance, momentum drag, and heat, water vapor, and CO2 exchange between canopy layers and the canopy atmosphere. Numerical schemes for heat and water transport in soil, ground surface energy balance, and soil respiration are also included. Both the stand‐alone MCANOPY and the coupled system (the WRF‐LES‐MCANOPY) are evaluated against data measured in the Canopy Horizontal Array Turbulence Study field experiment. The MCANOPY performs reasonably well in reproducing vertical profiles of mean and turbulent flows as well as second‐order statistical quantities including heat and scalar fluxes within the canopy under unstable stability conditions. The coupled WRF‐LES‐MCANOPY captures major features of canopy edge flows under both neutral and unstable conditions. Limitations of the MCANOPY are discussed for our further work. Our results suggest that our model can be a promising modeling system for a variety of applications to study canopy flows and scalar transport (e.g., CO2).

Purpose The student-managed investment fund (SMIF) program at California State University, Long Beach (CSULB), was launched in 1995 with one portfolio worth $50,000. In the two decades since then, the program has grown to include three portfolios with a combined value of more than $700,000, managed on behalf of three different clients. The purpose of this paper is to describe the creation, evolution and growth of the program including the development of the new quantitative approach and its subsequent implementation. The paper also discusses the ongoing organizational, educational and investment-management challenges associated with the program. Design/methodology/approach The paper includes a description of the development and evolution of the program along with a discussion of the investment results for one of its three portfolios. Findings The paper finds: the new quantitative approach implemented in the program is effective as insurance against “black swan” events; and SMIF-type programs can provide learning experiences both for students and faculty members. Practical implications The paper explains the practical application of the new quantitative approach as well as the educational benefits of a SMIF-type program. Originality/value The paper provides insight into the structure of CSULB’s SMIF program and discusses a unique quantitative approach to asset allocation and security selection.

A new type of zeolite composite antibacterial agents was prepared by introducing zinc oxide and copper ions into 13X zeolite through the coprecipitation and ion-exchange methods. The structural properties of the tested antibacterial material were characterized and the antibacterial activity was evaluated. In Cu2+/ZnO-13X (CZ-13), zinc oxide and copper ions were either embedded in the interlayer space or dispersed on surface of 13X zeolite. Excellent antimicrobial activity of CZ-13 was observed on Escherichia coli (E. coli) and Staphylococcus aureus (S.aureus). In the case of Cu2+/ZnO-13X, both MIC and MBC against E.coli were 0.2 mg/mL and 0.8 mg/mL. For S.aureus, CZ-13 also showed similar antibacterial properties. The bacterial cells turned from normal rod-shape into irregular shapes after treatment with the tested CZ-13. An increase of the intracellular enzyme activity after CZ-13 addition suggested that the permeability of the cell membrane increased and bacteria were damaged.

Nitrogen and sulfur-codoped reduced graphene oxide (RGO) was prepared with the assistance of an environmentally benign and facile route using an inductive coupled plasma (ICP) source. This novel ga...

The utilization of two isomorphic ligands with different substituents leads to two centrosymmetric DyIII dimers, namely, [Dy2(bfbpen)2(H2O)2]·2I- (1) and [Dy2(bcbpen)2(H2O)2]·2I-·0.5H2O (2) (H2bfbpen = N,N'-bis-(2-hydroxy-5-fluoro-benzyl)-N,N'-bis-(pyridin-2-ylmethyl)ethylenediamine and H2bcbpen = N,N'-bis-(2-hydroxy-5-chloro-benzyl)-N,N'-bis-(pyridin-2-ylmethyl)ethylenediamine). Although Dy ions in both compounds uniformly exhibit a square-antiprism geometry, the critical difference found in the terminal substituents of the two ligands fine-tunes the local crystal field around Dy centers and the dinuclear molecular structures of 1 and 2. Magnetic investigations unveil that both 1 and 2 display dynamic magnetic relaxation of single-molecule magnet (SMM) behaviour with different energy barriers of 20.9 K for 1 and 72.7 K for 2 under a zero direct-current (dc) field, as well as 26.9 K for 1 under a 1200 Oe dc field. Compared to 1, the stronger uniaxial anisotropy and magnetic exchange in 2 render it a better SMM as evidenced by the higher energy barrier. Ab initio calculations are also performed on both Dy2 compounds to rationalize the observed discrepancy in their magnetic behaviours. The contribution illustrates that the SMM behaviour could be effectively enhanced by means of deliberate local structural manipulation.

By means of the solvent effect, three new azido-copper 1D coordination polymers, [Cu(4-aba)(N3)] (1), [Cu(4-aba)(N3)(CH3OH)] (2), and [Cu(4-aba)(N3)(C2H5OH)] (3) (4-aba = 4-azidobenzoic acid), were successfully prepared in the presence of Cu2+ ion, NaN3 and 4-azidobenzoic acid. Interestingly, 1 can be employed as a precursor and transformed to 2 and 3via the coordination of methanol or ethanol, respectively. Meanwhile, the identical products of 1, namely 1a and 1b, could be obtained from both 2 and 3 by a dealcoholized process. As a result, the geometric configurations of Cu(II) ions vary from the tetracoordinated square-planar in 1 to the hexacoordinated octahedron in 2 or 3. Compound 1 displays a well-isolated 1D chain with dual-bridges of EO-azido and syn,syn-carboxylate, while isomorphic 2 and 3 are triple-bridged chain-like motifs containing EO-azido, syn,syn-carboxylate and μ2-alkanol. The structural transformations caused by the intervention of alkanol molecules modulate the intrachain Cu–Cu distances (3.570 for 1, 3.204 A for 2 and 3.154 A for 3) and Cu–N–Cu angles (127.3° for 1, 106.82° for 2 and 104.81° for 3). This modulation, however, further leads to different intrachain ferromagnetic interactions (J = 28.4 cm−1 for 1, 67.6 cm−1 for 2, 40.2 cm−1 for 3) that are qualitatively demonstrated by theoretical calculation. More importantly, the significant scenarios of magnetic ordering and slow magnetic relaxation, which are infrequent in most of the reported azido-copper cases, are only observed in 2 and 3, due to the distinct interchain networks among 1–3. In addition, heat-capacity measurements highlight the characteristics of long-range ferromagnetic ordering in 2 and 3.

To break the limitation of salt removal capacity of capacitive desalination (CDI), a novel dual-ion hybrid CDI (Di-HCDI) system is proposed which is composed of Na1.1V3O7.9@reduced graphene oxide (NVO@rGO) acting as the sodium ion intercalation electrode while Ag@rGO served as the chloride ion intercalation electrode. Once a direct voltage is applied, the faradaic redox reactions trigger on both electrodes, resulting in sodium ions and chloride ions being removed from the salty electrolyte. NVO exhibits a ribbon structure, having a high sodium intercalation capacity. By coupling with rGO, an ion conductor network is introduced, providing high sodium ion mobility as well as improving the structural stability due to the flexibility of rGO. As a result, the Ag@rGO‖NVO@rGO device demonstrates a superior desalination performance, i.e. ultra-high desalination capacity, rate capability and regeneration. When it was operated in NaCl solution with an initial concentration of 2000 mg L−1 at 1.4 V, the salt removal capacity was 82.2 mg g−1. Remarkably, the charge efficiency of the Ag@rGO‖NVO@rGO device reached 94.4% even in highly concentrated brine, indicating the co-ion effect has been restricted. Benefiting from this, the system proves a Di-HCDI strategy which reveals advances over most of the current CDIs.

The resonance 3C ([(2p5)1/23d3/2]J=1 → [2p6]J=0) to intercombination 3D ([(2p5)3/23d5/2]J=1 → [2p6]J=0) line intensity ratio of neonlike ions has been studied. The measured line intensity ratio for neonlike Xe44+ ions shows an apparent change, which is reproduced by the calculations using the relativistic configuration interaction plus many-body perturbation theory. It is clearly elucidated that the change in the 3C/3D line intensity ratio is caused by strong configuration mixing between the upper levels of the 3D and 3F ([(2p5)1/23s]J=1 → [2p6]J=0) lines. The present measurement allows us to discuss the 3C/3D line intensity ratio for the highest-Z ions hitherto, which suggests that the experiment-theory discrepancy in the 3C/3D line intensity ratio of neonlike ions diminishes with increasing atomic number Z and further trends to vanish at higher-Z ions. Furthermore, the present study provides benefits to better understand configuration mixing effect in the radiative opacity of hot plasmas.

Background: Studies have shown that excitatory amino acid transporter 3 (EAAT3) function inhibition is related to several neurodegenerative diseases. Our previous studies also found that the EAAT3 function is intimately linked to learning and memory. In this study, we examined the role of EAAT3 in postoperative cognitive dysfunction (POCD) and explored the potential benefit of riluzole against POCD. Methods: We performed mutation analysis of SLC1A1 (encoding EAAT3) gene exons in patients of different age groups and measured EAAT3 protein expression in hippocampus of mice at different ages. Next, we established a recombinant adeno-associated viral (rAAV)-mediated shRNA to knockdown EAAT3 expression in the hippocampus of adult male mice. And then the mice received 2μg of lipopolysaccharide (LPS) intracerebroventricular microinjection to construct the POCD model. In addition, we intraperitoneally injected 4mg/kg of riluzole 2 days before LPS microinjection for consecutive 3 days in elderly male mice. Cognitive function was assessed using a Morris water maze 24h after LPS microinjection. Animal behavioral tests, as well as pathological and biochemical assays, were performed to clarify the role of EAAT3 function in POCD and evaluate the effect of activation of EAAT3 function by riluzole. Results: We found that point mutation of SLC1A1 gene exon in elderly patients was significantly different from children and adult people, and expression of EAAT3 was significantly decreased in old mice. And EAAT3 knockdown in hippocampus aggravated LPS-induced learning and memory deficits in adult male mice, and LPS significantly inhibited hippocampal EAAT3 membrane protein expression and GluA1 protein phosphorylation level in adult male mice. Moreover, riluzole pretreatment significantly increased hippocampal EAAT3 membrane protein expression and ameliorated LPS-induced cognitive impairment in old male mice. Conclusions: Our results demonstrated that the dysfunction of EAAT3 is an important risk factor for POCD susceptibility and riluzole may be a promising strategy for prevention and treating of POCD in the elderly people.

Anxiety and depression are common mental illness in stroke caregivers, resulting in significant stress to the emotion health of caregivers. Caregivers’ emotion can seriously affect the recovery rate of stroke patient, therefore, how to control and affect the caregivers’ anxiety and depression is of great importance. Here three multiple centers observation and validation study were performed to screen out the risk factors for development of anxiety and depression in main family caregiver, and the effect of anxiety and depression of family caregivers on 6-month mortality of patients with moderate-severe stroke. The severity of the stroke, the duration of care time and the medical payment associated with increased risk of anxiety and depression. Anxiety and depression of main family caregivers are associated with increased risk 6-month mortality of patients with moderate-severe stroke. Therefore, the support provided to the family caregivers might have positive effect on prognosis of the patients with stroke.

Debye-screening effects on the electron-impact excitation (EIE) processes for the dipole-allowed transition 1s2 1 S → 1s2p 1P in He-like Al11+ and Fe24+ ions are investigated using the fully relativistic distorted-wave methods with the Debye–Hückel (DH) model potential. Debye-screening effects on the continuum-bound (CB) interaction and target ion are discussed, both of which result in reduction of EIE cross sections. This reduction due to screening on the CB interaction is dominant. The non-spherical and spherical DH potentials are adopted for considering the screening effect on the CB interaction. It is found that the spherical DH potential could significantly overestimate the influence of plasma screening on EIE cross sections for multielectron He-like ions.

To explore the application value of primary trauma treatment (PTC) teaching mode in special professional cardiopulmonary resuscitation (CPR) guide training.Cluster sampling method was adopted, and the residents' committee selected special occupation population from every town/sub-district office in the southern mountainous area of Ningxia Hui Autonomous Region for CPR training. A monthly session was held from January to December 2019, with personnel trained by traditional operation teaching and individual practice method from January to June 2019 as the control group and personnel trained by PTC teaching mode from July to December 2019 as the observation group. The two groups of trainers, training objectives and assessment standards were consistent. Questionnaire survey was conducted at the beginning and end of each training period, including the degree of mastery of first-aid knowledge and skills and the level of self-efficacy, etc., to evaluate the training effect.There were 503 trainees in each group, and there was no significant difference in gender, age, education and occupation distribution between the two groups. There was no significant difference in the first aid principles, CPR skill level and self-efficacy between the two groups before the training. The first aid principle, CPR skills level and self-efficacy of the two groups after training were all improved, and the principle of first aid and CPR skills level in the observation group was obviously higher than that in the control group (first aid related concepts: 4.39±0.76 vs. 3.87±0.89, gold life-saving time: 5.71±0.49 vs. 4.53±0.62, the meaning of the first witnesses: 5.33±0.82 vs. 4.18±0.78, cardiac, respiratory cardiac arrest in the judgment: 5.12±0.73 vs. 4.07±0.73, CPR skills: 5.29±0.64 vs. 4.15±0.71, all P0.05). The self-efficacy score of the observation group was significantly higher than that of the control group (emergency attitude: 18.17±1.24 vs. 17.35±1.25, self-efficacy: 13.56±1.54 vs. 11.35±1.26, behavioral intention: 9.56±0.84 vs. 8.92±0.95, all P0.05).The application of PTC teaching mode in the training of CPR guidelines for special professions has significant effects, which can effectively help special professions to master CPR knowledge and skills, and has promotion value.

Momentum and mass exchanges between the atmosphere and forests situated on complex terrain continue to draw significant research attention primarily because of their significance to a plethora of applications. In this paper, we investigated flows behavior on the leeward side of a two-dimensional forested ridge under neutrally stratified conditions using large-eddy simulations (LESs). The goal is to understand how variations in leaf area index (LAI), vertical canopy foliage distributions, and forest edge positions affect mean/turbulent flow statistics, momentum fluxes, and onset of recirculation patterns. Although pressure perturbations are dominated by the hill shape, it is demonstrated here that changes in canopy foliage distribution modulate intensities and patterns of the leeward adverse pressure gradients. Such changes in the adverse pressure gradients alter the mean velocity streamlines including the patterns and magnitudes of the leeward downward mean vertical velocity and the velocity variances and momentum flux in the wake region. While a downwind recirculation zone develops in all cases, the details regarding the incipient location and recirculation zone size vary including positions of the separation and reattachment points. Furthermore, changes in the strength and depth of the zone occur due to canopy-induced changes in adverse pressure gradients, advection, and canopy drag. Because the recirculation zone impacts the local mean advective terms in momentum and scalar exchanges, the simulations here indicate that canopy morphology-induced changes in the leeward flows have significant implications to both measurements and models of biosphere-atmosphere exchange over complex terrain.

In this study, a Rh(I)/Ru(III) catalyst with a bimetallic space structure was designed and synthesized. The interaction between the metals of the bimetallic catalyst and the structure of the bridged dimer can effectively reduce the steric hindrance effect and help speed up the reaction rate while ensuring the stability of the catalyst. X-ray photoelectron spectroscopy (XPS) results show that rhodium accepts electrons from chlorine, thereby increasing the electron-rich nature of rhodium and improving the catalytic activity. This promotes the nucleophilic reaction of the catalyst with methyl iodide and reduces the reaction energy barrier. The methanol carbonylation performance of the Rh/Ru catalyst was evaluated, and the results show that the conversion rate of methyl acetate and the yield of acetic acid are 96.0% under certain conditions. Furthermore, during the catalysis, no precipitate is formed and the amount of water is greatly reduced. It can be seen that the catalyst has good stability and activity.

Multifunctional ultrafiltration membranes, which achieve ultrafiltration and additional functions in one unit, are a new strategy developed in recent years for wastewater treatment. In this mini review, we summarized and commented on the development of adsorptive and catalytically oxidative multifunctional ultrafiltration membranes, as well as pointed out possible further trends. The main methods for membrane preparation, i.e., blending, surface coating, reverse filtration, etc., were summarized, and the advantages and disadvantages of each method were discussed. In addition, the key criteria which influence the performance of membranes, including the efficiency of additional functions, original ultrafiltration, permeance, and stability, were analyzed. Furthermore, we introduced the applications of different classes of multifunctional ultrafiltration membranes, and tried to further analyzed some examples of multifunctional ultrafiltration membranes used for adsorption and catalytic oxidation. The most significant advantage of this technology is the high efficiency for the simultaneous removal of different kinds of pollutants or for the removal of one kind of pollutant during the deep treatment of multicomponent wastewater. However, some challenges still oppose the practical application of multifunctional ultrafiltration. We believe that breaking the trade-off between the high efficiency of additional functions and high flux, strengthening the stability of the membranes, achieving synergistic effects between multi-effect functions, and investigating the interaction mechanisms between active materials and the membrane are key points for further research.

Minimization and stabilization of arsenic-containing smelting wastewater and residue is of crucial issue to resolve the arsenic contamination. Calcium arsenate is a typical precipitate produced from disposal of smelting acid wastewater. However, it suffers from poor stability and large quantity in the aqueous environment. Copper slags, as for rich-iron species materials, are disposed of in landfills or open-air tailing ponds, which are another waste material that have not been effectively utilized for reuse application. In this study, strategy for sequence of phase-controlled and thermal-doped copper slag technique was used as the efficient means of minimization and stabilization of arsenic-bearing resides. Detailed results were showed that stepwise phase precipitation significantly reduced the formation of hazardous solid waste; the total solid waste was reduced 47.0 wt% because the gypsum was separated from arsenic calcium residues through two-step methods. Subsequently, solid waste stabilization was achieved by using thermal-doped slag, and the high yield of magnetite (75.6 wt%) and fayalite (22.7 wt%) was produced from copper slags. It was proved that these iron-rich species displayed the remarkable performance to stabilize arsenic due to the formation of Fe-As-Ca-O complex; compared with the raw solid waste, the arsenic leachability was decreased from 280.75 to 1.05 mg/L via copper slag stabilization process. The immobilized arsenic content was 25.0 wt%. Overall, the proposed strategy for stepwise phase-controlled and thermal-doped copper slags was a potentially effective strategy for reducing emissions and pollution of arsenic-containing wastewater and residue.