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Your search keyword '"Yuan, Weizhong"' showing total 453 results
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453 results on '"Yuan, Weizhong"'

103. Reversible Thermoresponsive Hydrogel Fabricated from Natural Biopolymer for the Improvement of Critical Limb Ischemia by Controlling Release of Stem Cells

Author

Xue Li, Yebin Ni, Rui Wang, Li Maoquan, Li Tingyu, Ligong Lu, Xueliang Yao, Yuan Weizhong, Mingming Jin, and Xie Xiaoyun

Subjects
Male, Biocompatibility, Angiogenesis, Biomedical Engineering, Ischemia, Mice, Nude, Neovascularization, Physiologic, Pharmaceutical Science, 02 engineering and technology, Methylcellulose, 010402 general chemistry, 01 natural sciences, Biomaterials, Mice, Biopolymers, Pregnancy, Fibrosis, medicine, Animals, Humans, Neovascularization, Pathologic, Chemistry, Stem Cells, Temperature, Extremities, Hydrogels, Critical limb ischemia, 021001 nanoscience & nanotechnology, medicine.disease, Cytoprotection, 0104 chemical sciences, Cell biology, Mice, Inbred C57BL, Perfusion, body regions, Transplantation, HEK293 Cells, Pregnancy, Animal, Female, Stress, Mechanical, Atrophy, medicine.symptom, Stem cell, Rheology, 0210 nano-technology, Stem Cell Transplantation
Abstract

Stem cells therapy is an effective treatment for critical limb ischemia diseases (CLI), but is limited to low cells retention and poor target release in severe ischemia tissues. Due to the notable feature of CLI, namely, the temperature of ischemia tissues decreases with the severity of the lesions, a thermoresponsive and reversible hydrogel based on methylcellulose-salt system encapsulating stem cells is facilely prepared and successfully achieved the goal of releasing stem cells in lower temperature areas. The investigations show that the thermogel presents notable biocompatibility, thermoresponsiveness, and cytoprotection. Furthermore, the combined transplantation of hydrogel and stem cells system effectively inhibits the fibrosis and muscular atrophy of lower limb ischemia, accelerates the recovery of lower limb blood flow, and promotes angiogenesis, indicating that the reversible thermogel can promote vascular repair by controlling the release of loaded stem cells in the treatment of CLI.

Published
2019
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115. Preparation and characterization of novel poly[cyclotriphosphazene-co-(4,4′-sulfonyldiphenol)] nanofiber matrices

Author

Huang Xiaobin, Tang Xiao-zhen, Pan Yang, Zhu Lu, and Yuan Weizhong

Subjects
chemistry.chemical_classification, Materials science, Polymers and Plastics, Chemical structure, Organic Chemistry, Nuclear magnetic resonance spectroscopy, Polymer, Matrix (mathematics), Synthetic fiber, Polymerization, chemistry, Nanofiber, Polymer chemistry, Materials Chemistry, Chemical decomposition
Abstract

Novel poly[cyclotriphosphazene-co-(4,4′-sulfonyldiphenol)] nanofiber matrices were synthesized via a facile one-pot polymerization. The fibers are 20–50 nm in diameter and 500 nm or more in length. Uniform nanoscale fibers linked covalently with each other and formed three-dimensional matrices. The highly cross-linked chemical structure of the nanofiber matrices was measured by means of Fourier transform infrared and quantitative solid-state NMR spectroscopy. Experiments show the pH had an effect on the hydrolytic degradation of the polymer. The hydrolysis of the matrices could be accelerated by alkaline conditions. The as-synthesized nanofiber matrices have potential applications in tissue engineering materials. Copyright © 2006 Society of Chemical Industry

Published
2006
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116. A superhydrophobic poly(lactic acid) electrospun nanofibrous membrane surface-functionalized with TiO2 nanoparticles and methyltrichlorosilane for oil/water separation and dye adsorption.

Author

Zhou, Zixuan, Liu, Lejing, and Yuan, Weizhong

Subjects
LACTIC acid, SURFACE energy, CONTACT angle, ADSORPTION (Chemistry), PETROLEUM, METHYLENE blue, POLYVINYLIDENE fluoride, POLYMERIC membranes
Abstract

A functionalized nanofiber membrane with high oil/water separation efficiency and methylene blue adsorption has been successfully fabricated by electrospinning and a surface modification approach. The substrate poly(lactic acid) (PLA) nanofiber film was firstly coated with titanium dioxide (TiO2) nanoparticles (NPs) by the sol–gel method. Then, polysiloxane formed by the hydrolysis and polycondensation of methyltrichlorosilane (MTS) was deposited on the modified nanofiber surface to increase the surface roughness and reduce the surface energy. The PLA nanofibrous membrane functionalized with TiO2 NPs and MTS exhibited excellent superhydrophobicity (water contact angle = 157.4 ± 0.9°), high permeation flux (2297.6 ± 51.6 L m−2 h−1) and ideal filtration efficiency (98.4 ± 1.0%). Moreover, the functionalized nanofibrous membrane could also achieve rapid and recyclable adsorption of toxic dyes such as methylene blue in aqueous solution. It provides a new prospect to facilely fabricate nanofibrous membrane materials to achieve the dual functions of oil/water separation and removal of toxic dyes with high efficiency. [ABSTRACT FROM AUTHOR]

Published
2019
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129. A fluorescent nanoprobe based on cellulose nanocrystals with porphyrin pendants for selective quantitative trace detection of Hg2+.

Author

Chen, Jiangdi, Zhou, Zixuan, Chen, Zixun, Yuan, Weizhong, and Li, Maoquan

Subjects
CELLULOSE nanocrystals, FLUORESCENT probes, TRACE element analysis
Abstract

A well-dispersed chemosensor based on cellulose nanocrystals (CNCs) with porphyrin pendants (CNC-SA-COOC6TPP) was facilely synthesized by the combination of carboxylation, extended esterification and dicyclohexylcarbodiimide (DCC) reaction. The CNC-SA-COOC6TPP nanomaterials promoted the solubility of porphyrin groups in water and the nanomaterials could be easily separated from water by filtering. The structure of CNC-SA-COOC6TPP nanomaterials could be verified by FT-IR, 1H NMR and XPS characterization. The TEM images showed that CNC-SA-COOC6TPP nanomaterials presented needle-like morphologies. The unique properties of high sensitivity and selectivity for Hg2+ of porphyrin-modified CNCs were investigated separately via fluorescence emission spectroscopy under characteristic excitation wavelengths of porphyrin moieties. Further investigation revealed that CNC-SA-COOC6TPP nanomaterials (0.01 wt% in H2O) could specifically detect Hg2+ with a detection limit for Hg2+ of ca. 5.0 × 10−8 mol L−1 (50 nM). In addition, Hg2+ was specifically detected with interference from other metal ions, which was attributed to the specific formation of the Hg2+–porphyrin complex with an interaction stoichiometry of one Hg2+ per porphyrin moiety. The concentration of all other metal ions could be qualitatively detected based on the relationship between fluorescence intensity and concentration. As a result, the good dispersion of cellulose nanocrystals and the high selectively and sensitivity of porphyrin pendants resulted in the highly efficient detection of Hg2+ in water, which makes CNC-SA-COOC6TPP a promising fluorescence chemosensor. [ABSTRACT FROM AUTHOR]

Published
2017
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137. The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healingElectronic supplementary information (ESI) available: A detailed Experimental section and FT-IR and 1H NMR spectra of materials. See DOI: 10.1039/c9bm01207a

Author

Wang, Chunyao, Liang, Chenyu, Wang, Rui, Yao, Xueliang, Guo, Peng, Yuan, Weizhong, Liu, Yang, Song, Ye, Li, Zhihong, and Xie, Xiaoyun

Abstract

Unhealable diabetic wounds and disabling scar formation in severe wounds need to be addressed with the help of multiple techniques. Here we put forward an idea to use exosomes loaded into a supporting scaffold to rebuild the vascular transportation system, which could solve hypoxia and infertility in these wounds. A highly efficient self-healing and biocompatible natural-based methylcellulose-chitosan hydrogel loaded with biological exosome nanoparticles has the appropriate strength and is made by an easy preparation process, and it eventually achieves the integrated structure needed for healing severe diabetic conditions. Hydrogels perform well in the cell proliferation and skin remodeling stages because of their three-dimensional porous structure, and self-healing and adhesion properties. Also, exosomes accumulated to an effective concentration for a period of time could induce proliferation, especially relating to vascular formation. After the overpass (vascular) has been constructed with the help of the base (hydrogel) and workers (exosomes), the society (skin) is reconstructed under a system of supply and regulation. The research results indicate that these novel complex hydrogels loaded with exosomes provide wide prospects for the healing of severe wounds.

Published
2019
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