32,014 results on '"Yu, Xin"'
Search Results
102. Water use efficiency in China is impacted by climate change and land use and land cover
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Fu, Yimin, Jian, Shengqi, and Yu, Xin
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- 2024
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103. TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway
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Song, Jia, Sun, Dong-lei, Li, Chen-yang, Luo, Yu-xin, Liu, Qian, Yao, Yue, Zhang, Hong, Yang, Ting-ting, Song, Mei, Bai, Xin-li, and Zhang, Xiao-lan
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- 2024
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104. Where is the money? Insights into China’s post-COVID healthcare corruption-busting campaign
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Su, Zhaohui, Bentley, Barry L., Yu, Xin, Jiang, Jianlin, Liu, Yifan, McDonnell, Dean, Cheshmehzangi, Ali, da Veiga, Claudimar Pereira, and Xiang, Yu-Tao
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- 2024
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105. Research Progress of Caspase in Endometriosis
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Yang, Yuan, Li, Lei-Lei, Qi, Yu-Xin, and Liu, Da-Jiang
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- 2024
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106. Irrigation combines with nitrogen application to optimize soil carbon and nitrogen, increase maize yield, and nitrogen use efficiency
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Li, Zhen Wei, Wang, Gui Yang, Khan, Kashif, Yang, Li, Chi, Yu Xin, Wang, Yong, and Zhou, Xun Bo
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- 2024
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107. Fabrication of MXene-Bi2WO6 heterojunction by Bi2Ti2O7 hinge for extraordinary LED-light-driven photocatalytic performance
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Li, Zhiwen, Xu, Liangliang, Babar, Zaheer Ud Din, Raza, Ali, Zhang, Yifei, Gu, Xinrui, Miao, Yu-Xin, Zhao, Zhen, and Li, Gao
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- 2024
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108. Engineered interface of three-dimensional coralliform NiS/FeS2 heterostructures for robust electrocatalytic water cleavage
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Yu, Xin, Mei, Jing, Du, Yeshuang, Cheng, Xiaohong, Wang, Xing, and Wu, Qi
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- 2024
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109. Optimizing Stock Portfolio Performance with a Combined RG1-TOPSIS Model: Insights from the Chinese Market
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Tan, YingShuang, Yang, Wanshuo, Suntrayuth, Sid, Yu, Xin, Sindakis, Stavros, and Showkat, Saloome
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- 2024
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110. Functional Bayesian Tucker Decomposition for Continuous-indexed Tensor Data
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Fang, Shikai, Yu, Xin, Wang, Zheng, Li, Shibo, Kirby, Mike, and Zhe, Shandian
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Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Tucker decomposition is a powerful tensor model to handle multi-aspect data. It demonstrates the low-rank property by decomposing the grid-structured data as interactions between a core tensor and a set of object representations (factors). A fundamental assumption of such decomposition is that there are finite objects in each aspect or mode, corresponding to discrete indexes of data entries. However, real-world data is often not naturally posed in this setting. For example, geographic data is represented as continuous indexes of latitude and longitude coordinates, and cannot fit tensor models directly. To generalize Tucker decomposition to such scenarios, we propose Functional Bayesian Tucker Decomposition (FunBaT). We treat the continuous-indexed data as the interaction between the Tucker core and a group of latent functions. We use Gaussian processes (GP) as functional priors to model the latent functions. Then, we convert each GP into a state-space prior by constructing an equivalent stochastic differential equation (SDE) to reduce computational cost. An efficient inference algorithm is developed for scalable posterior approximation based on advanced message-passing techniques. The advantage of our method is shown in both synthetic data and several real-world applications. We release the code of FunBaT at \url{https://github.com/xuangu-fang/Functional-Bayesian-Tucker-Decomposition}.
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- 2023
111. Text-to-3D with Classifier Score Distillation
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Yu, Xin, Guo, Yuan-Chen, Li, Yangguang, Liang, Ding, Zhang, Song-Hai, and Qi, Xiaojuan
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Graphics - Abstract
Text-to-3D generation has made remarkable progress recently, particularly with methods based on Score Distillation Sampling (SDS) that leverages pre-trained 2D diffusion models. While the usage of classifier-free guidance is well acknowledged to be crucial for successful optimization, it is considered an auxiliary trick rather than the most essential component. In this paper, we re-evaluate the role of classifier-free guidance in score distillation and discover a surprising finding: the guidance alone is enough for effective text-to-3D generation tasks. We name this method Classifier Score Distillation (CSD), which can be interpreted as using an implicit classification model for generation. This new perspective reveals new insights for understanding existing techniques. We validate the effectiveness of CSD across a variety of text-to-3D tasks including shape generation, texture synthesis, and shape editing, achieving results superior to those of state-of-the-art methods. Our project page is https://xinyu-andy.github.io/Classifier-Score-Distillation, Comment: Our project page is https://xinyu-andy.github.io/Classifier-Score-Distillation
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- 2023
112. QCD equation of state and thermodynamic observables from computationally minimal Dyson-Schwinger Equations
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Lu, Yi, Gao, Fei, Liu, Yu-Xin, and Pawlowski, Jan M.
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High Energy Physics - Phenomenology ,Nuclear Experiment ,Nuclear Theory - Abstract
We study the QCD equation of state and other thermodynamic observables including the isentropic trajectories and the speed of sound. These observables are of eminent importance for the understanding of experimental results in heavy ion collisions and also provide a QCD input for studies of the timeline of heavy-ion-collisions with hydrodynamical simulations. They can be derived from the quark propagator whose gap equation is solved within a minimal approximation to the Dyson-Schwinger equations of QCD at finite temperature and density. This minimal approximation aims at a combination of computational efficiency and simplification of the truncation scheme while maintaining quantitative precision. This minimal DSE scheme is confronted and benchmarked with results for correlation functions and observables from first principles QCD lattice at vanishing density and quantitative functional approaches at finite density., Comment: 14 pages, 13 figures
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- 2023
113. Measurement and feedforward induced entanglement negativity transition
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Seif, Alireza, Wang, Yu-Xin, Movassagh, Ramis, and Clerk, Aashish A.
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Quantum Physics ,Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Statistical Mechanics - Abstract
We study the interplay between measurement-induced dynamics and conditional unitary evolution in quantum systems. We numerically and analytically investigate commuting random measurement and feedforward (MFF) processes, and find a sharp transition in their ability to generate entanglement negativity as the number of MFF channels varies. We also establish a direct connection between these findings and transitions induced by random dephasing from an environment with broken time-reversal symmetry. In one variant of the problem, we employ free probability theory to rigorously prove the transition's existence. Furthermore, these MFF processes have dynamic circuit representations that can be experimentally explored on current quantum computing platforms., Comment: Close to final published version. 6 pages, 4 figures (main) + 14 pages, 5 figures (supplementary materials)
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- 2023
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114. Constructing the Equation of State of QCD in a functional QCD based scheme
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Lu, Yi, Gao, Fei, Fu, Bao-Chi, Song, Hui-Chao, and Liu, Yu-Xin
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High Energy Physics - Phenomenology ,Nuclear Experiment ,Nuclear Theory - Abstract
We construct the equation of state (EoS) of QCD based on the finite chemical potential information from the functional QCD approaches, with the assistance of the lattice QCD EoS. The obtained EoS is consistent with the up-to-date estimations of the QCD phase diagram, including a phase transition temperature at zero chemical potential of $T=155$ MeV, the curvature of the transition line $\kappa=0.016$ and also a critical end point at $(T,\mu_B)=(118, 600)$ MeV. In specific, the phase diagram mapping is achieved by incorporating the order parameters into the EoS, namely the dynamical quark mass for the chiral phase transition together with the Polyakov loop parameter for the deconfinement phase transition. We also implement the EoS in hydrodynamic simulations to compute the particle yields, ratios and collective flow, and find that our obtained EoS agrees well with the commonly used one based on the combination of lattice QCD simulation and hadron resonance gas model., Comment: 8 pages, 12 figures
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- 2023
115. Streaming Factor Trajectory Learning for Temporal Tensor Decomposition
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Fang, Shikai, Yu, Xin, Li, Shibo, Wang, Zheng, Kirby, Robert, and Zhe, Shandian
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Computer Science - Machine Learning - Abstract
Practical tensor data is often along with time information. Most existing temporal decomposition approaches estimate a set of fixed factors for the objects in each tensor mode, and hence cannot capture the temporal evolution of the objects' representation. More important, we lack an effective approach to capture such evolution from streaming data, which is common in real-world applications. To address these issues, we propose Streaming Factor Trajectory Learning for temporal tensor decomposition. We use Gaussian processes (GPs) to model the trajectory of factors so as to flexibly estimate their temporal evolution. To address the computational challenges in handling streaming data, we convert the GPs into a state-space prior by constructing an equivalent stochastic differential equation (SDE). We develop an efficient online filtering algorithm to estimate a decoupled running posterior of the involved factor states upon receiving new data. The decoupled estimation enables us to conduct standard Rauch-Tung-Striebel smoothing to compute the full posterior of all the trajectories in parallel, without the need for revisiting any previous data. We have shown the advantage of SFTL in both synthetic tasks and real-world applications. The code is available at {https://github.com/xuangu-fang/Streaming-Factor-Trajectory-Learning}.
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- 2023
116. Dynamical and finite-size effects on the signal of first-order phase transition
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Jiang, Lijia, Gao, Fei, and Liu, Yu-xin
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Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
We study the dynamical behaviors of the criterion identifying the first-order phase transition in the matter generated by the relativistic heavy-ion collisions, by explicitly involving the dynamical effects based on the Fokker-Plank framework. The perspectives we taken into account range from phase transition scenarios, initial temperatures, volume effect, relaxation rates, and evolution trajectories. Our numerical calculations show that the dynamical signal of the first-order phase transition can be reserved in certain conditions. Besides the delaying effects due to a finite relaxation time, a larger initial temperature, a smaller volume, a larger relaxation rate, or bending of the trajectory will lead to reduction of the signal. Our discussions on the criterion offer valuable reference information for the experimental detection of the first-order phase transition signal., Comment: 9 pages, 7 figures
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- 2023
117. Dyson-Schwinger equations towards cold-dense QCD matter with improved truncations
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Bai, Zhan and Liu, Yu-Xin
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High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
We take the Dyson-Schwinger equation (DSE) approach of QCD to study the phase transition and the equation of state of cold dense matter. Besides the bare vertex and Gauss gluon model, we take into account an improved truncation scheme, the CLRQ vertex and infrared-constant gluon model. For the dynamical chiral symmetry breaking solution of the DSE, we require that the emergence of quark number density to be at the chemical potential for the nuclear liquid-gas phase transition to take place, by incorporating a chemical potential dependent modification factor to the gluon model. The result shows that our modified scheme can not only describe the phase transition of the cold dense matter well but also the deduced equation of state of the matter can describe the recent astronomical observations consistently.
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- 2023
118. Open-CRB: Towards Open World Active Learning for 3D Object Detection
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Chen, Zhuoxiao, Luo, Yadan, Wang, Zixin, Wang, Zijian, Yu, Xin, and Huang, Zi
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
LiDAR-based 3D object detection has recently seen significant advancements through active learning (AL), attaining satisfactory performance by training on a small fraction of strategically selected point clouds. However, in real-world deployments where streaming point clouds may include unknown or novel objects, the ability of current AL methods to capture such objects remains unexplored. This paper investigates a more practical and challenging research task: Open World Active Learning for 3D Object Detection (OWAL-3D), aimed at acquiring informative point clouds with new concepts. To tackle this challenge, we propose a simple yet effective strategy called Open Label Conciseness (OLC), which mines novel 3D objects with minimal annotation costs. Our empirical results show that OLC successfully adapts the 3D detection model to the open world scenario with just a single round of selection. Any generic AL policy can then be integrated with the proposed OLC to efficiently address the OWAL-3D problem. Based on this, we introduce the Open-CRB framework, which seamlessly integrates OLC with our preliminary AL method, CRB, designed specifically for 3D object detection. We develop a comprehensive codebase for easy reproducing and future research, supporting 15 baseline methods (\textit{i.e.}, active learning, out-of-distribution detection and open world detection), 2 types of modern 3D detectors (\textit{i.e.}, one-stage SECOND and two-stage PV-RCNN) and 3 benchmark 3D datasets (\textit{i.e.}, KITTI, nuScenes and Waymo). Extensive experiments evidence that the proposed Open-CRB demonstrates superiority and flexibility in recognizing both novel and known classes with very limited labeling costs, compared to state-of-the-art baselines. Source code is available at \url{https://github.com/Luoyadan/CRB-active-3Ddet/tree/Open-CRB}.
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- 2023
119. CBARF: Cascaded Bundle-Adjusting Neural Radiance Fields from Imperfect Camera Poses
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Fu, Hongyu, Yu, Xin, Li, Lincheng, and Zhang, Li
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Existing volumetric neural rendering techniques, such as Neural Radiance Fields (NeRF), face limitations in synthesizing high-quality novel views when the camera poses of input images are imperfect. To address this issue, we propose a novel 3D reconstruction framework that enables simultaneous optimization of camera poses, dubbed CBARF (Cascaded Bundle-Adjusting NeRF).In a nutshell, our framework optimizes camera poses in a coarse-to-fine manner and then reconstructs scenes based on the rectified poses. It is observed that the initialization of camera poses has a significant impact on the performance of bundle-adjustment (BA). Therefore, we cascade multiple BA modules at different scales to progressively improve the camera poses. Meanwhile, we develop a neighbor-replacement strategy to further optimize the results of BA in each stage. In this step, we introduce a novel criterion to effectively identify poorly estimated camera poses. Then we replace them with the poses of neighboring cameras, thus further eliminating the impact of inaccurate camera poses. Once camera poses have been optimized, we employ a density voxel grid to generate high-quality 3D reconstructed scenes and images in novel views. Experimental results demonstrate that our CBARF model achieves state-of-the-art performance in both pose optimization and novel view synthesis, especially in the existence of large camera pose noise.
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- 2023
120. Divide and Ensemble: Progressively Learning for the Unknown
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Zhang, Hu, Shen, Xin, Du, Heming, Chen, Huiqiang, Liu, Chen, Sheng, Hongwei, Xu, Qingzheng, Khan, MD Wahiduzzaman, Yu, Qingtao, Zhu, Tianqing, Chapman, Scott, Huang, Zi, and Yu, Xin
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Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
In the wheat nutrient deficiencies classification challenge, we present the DividE and EnseMble (DEEM) method for progressive test data predictions. We find that (1) test images are provided in the challenge; (2) samples are equipped with their collection dates; (3) the samples of different dates show notable discrepancies. Based on the findings, we partition the dataset into discrete groups by the dates and train models on each divided group. We then adopt the pseudo-labeling approach to label the test data and incorporate those with high confidence into the training set. In pseudo-labeling, we leverage models ensemble with different architectures to enhance the reliability of predictions. The pseudo-labeling and ensembled model training are iteratively conducted until all test samples are labeled. Finally, the separated models for each group are unified to obtain the model for the whole dataset. Our method achieves an average of 93.6\% Top-1 test accuracy~(94.0\% on WW2020 and 93.2\% on WR2021) and wins the 1$st$ place in the Deep Nutrient Deficiency Challenge~\footnote{https://cvppa2023.github.io/challenges/}.
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- 2023
121. Uncovering measurement-induced entanglement via directional adaptive dynamics and incomplete information
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Wang, Yu-Xin, Seif, Alireza, and Clerk, Aashish A.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The rich entanglement dynamics and transitions exhibited by monitored quantum systems typically only exist in the conditional state, making observation extremely difficult. In this work we construct a general recipe for mimicking the conditional entanglement dynamics of a monitored system in a corresponding measurement-free dissipative system involving directional interactions between the original system and a set of auxiliary register modes. This mirror setup autonomously implements a measurement-feedforward dynamics that effectively retains a small fraction of the information content in a typical measurement record. We illustrate our ideas in a bosonic system featuring a competition between entangling measurements and local unitary dynamics, and also discuss extensions to qubit systems and truly many-body systems., Comment: 7+11 pages, 4+7 figures
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- 2023
122. DeformUX-Net: Exploring a 3D Foundation Backbone for Medical Image Segmentation with Depthwise Deformable Convolution
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Lee, Ho Hin, Liu, Quan, Yang, Qi, Yu, Xin, Bao, Shunxing, Huo, Yuankai, and Landman, Bennett A.
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Computer Science - Computer Vision and Pattern Recognition - Abstract
The application of 3D ViTs to medical image segmentation has seen remarkable strides, somewhat overshadowing the budding advancements in Convolutional Neural Network (CNN)-based models. Large kernel depthwise convolution has emerged as a promising technique, showcasing capabilities akin to hierarchical transformers and facilitating an expansive effective receptive field (ERF) vital for dense predictions. Despite this, existing core operators, ranging from global-local attention to large kernel convolution, exhibit inherent trade-offs and limitations (e.g., global-local range trade-off, aggregating attentional features). We hypothesize that deformable convolution can be an exploratory alternative to combine all advantages from the previous operators, providing long-range dependency, adaptive spatial aggregation and computational efficiency as a foundation backbone. In this work, we introduce 3D DeformUX-Net, a pioneering volumetric CNN model that adeptly navigates the shortcomings traditionally associated with ViTs and large kernel convolution. Specifically, we revisit volumetric deformable convolution in depth-wise setting to adapt long-range dependency with computational efficiency. Inspired by the concepts of structural re-parameterization for convolution kernel weights, we further generate the deformable tri-planar offsets by adapting a parallel branch (starting from $1\times1\times1$ convolution), providing adaptive spatial aggregation across all channels. Our empirical evaluations reveal that the 3D DeformUX-Net consistently outperforms existing state-of-the-art ViTs and large kernel convolution models across four challenging public datasets, spanning various scales from organs (KiTS: 0.680 to 0.720, MSD Pancreas: 0.676 to 0.717, AMOS: 0.871 to 0.902) to vessels (e.g., MSD hepatic vessels: 0.635 to 0.671) in mean Dice., Comment: 14 pages, the source code with our pre-trained model is available at this https://github.com/MASILab/deform-uxnet
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- 2023
123. Multi-Resolution Active Learning of Fourier Neural Operators
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Li, Shibo, Yu, Xin, Xing, Wei, Kirby, Mike, Narayan, Akil, and Zhe, Shandian
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Computer Science - Machine Learning - Abstract
Fourier Neural Operator (FNO) is a popular operator learning framework. It not only achieves the state-of-the-art performance in many tasks, but also is efficient in training and prediction. However, collecting training data for the FNO can be a costly bottleneck in practice, because it often demands expensive physical simulations. To overcome this problem, we propose Multi-Resolution Active learning of FNO (MRA-FNO), which can dynamically select the input functions and resolutions to lower the data cost as much as possible while optimizing the learning efficiency. Specifically, we propose a probabilistic multi-resolution FNO and use ensemble Monte-Carlo to develop an effective posterior inference algorithm. To conduct active learning, we maximize a utility-cost ratio as the acquisition function to acquire new examples and resolutions at each step. We use moment matching and the matrix determinant lemma to enable tractable, efficient utility computation. Furthermore, we develop a cost annealing framework to avoid over-penalizing high-resolution queries at the early stage. The over-penalization is severe when the cost difference is significant between the resolutions, which renders active learning often stuck at low-resolution queries and inferior performance. Our method overcomes this problem and applies to general multi-fidelity active learning and optimization problems. We have shown the advantage of our method in several benchmark operator learning tasks. The code is available at https://github.com/shib0li/MRA-FNO.
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- 2023
124. Baichuan 2: Open Large-scale Language Models
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Yang, Aiyuan, Xiao, Bin, Wang, Bingning, Zhang, Borong, Bian, Ce, Yin, Chao, Lv, Chenxu, Pan, Da, Wang, Dian, Yan, Dong, Yang, Fan, Deng, Fei, Wang, Feng, Liu, Feng, Ai, Guangwei, Dong, Guosheng, Zhao, Haizhou, Xu, Hang, Sun, Haoze, Zhang, Hongda, Liu, Hui, Ji, Jiaming, Xie, Jian, Dai, JunTao, Fang, Kun, Su, Lei, Song, Liang, Liu, Lifeng, Ru, Liyun, Ma, Luyao, Wang, Mang, Liu, Mickel, Lin, MingAn, Nie, Nuolan, Guo, Peidong, Sun, Ruiyang, Zhang, Tao, Li, Tianpeng, Li, Tianyu, Cheng, Wei, Chen, Weipeng, Zeng, Xiangrong, Wang, Xiaochuan, Chen, Xiaoxi, Men, Xin, Yu, Xin, Pan, Xuehai, Shen, Yanjun, Wang, Yiding, Li, Yiyu, Jiang, Youxin, Gao, Yuchen, Zhang, Yupeng, Zhou, Zenan, and Wu, Zhiying
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Computer Science - Computation and Language - Abstract
Large language models (LLMs) have demonstrated remarkable performance on a variety of natural language tasks based on just a few examples of natural language instructions, reducing the need for extensive feature engineering. However, most powerful LLMs are closed-source or limited in their capability for languages other than English. In this technical report, we present Baichuan 2, a series of large-scale multilingual language models containing 7 billion and 13 billion parameters, trained from scratch, on 2.6 trillion tokens. Baichuan 2 matches or outperforms other open-source models of similar size on public benchmarks like MMLU, CMMLU, GSM8K, and HumanEval. Furthermore, Baichuan 2 excels in vertical domains such as medicine and law. We will release all pre-training model checkpoints to benefit the research community in better understanding the training dynamics of Baichuan 2., Comment: Baichuan 2 technical report. Github: https://github.com/baichuan-inc/Baichuan2
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- 2023
125. Pound-Drever-Hall Feedforward: Laser Phase Noise Suppression beyond Feedback
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Chao, Yu-Xin, Hua, Zhen-Xing, Liang, Xin-Hui, Yue, Zong-Pei, You, Li, and Tey, Meng Khoon
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Physics - Optics ,Condensed Matter - Quantum Gases ,Physics - Applied Physics ,Physics - Atomic Physics - Abstract
Pound-Drever-Hall (PDH) laser frequency stabilization is a powerful technique widely used for building narrow-linewidth lasers. This technique is however ineffective in suppressing high-frequency (>100~kHz) laser phase noise detrimental for many applications. Here, we introduce an effective method which can greatly enhance its high-frequency performance. The idea is to recycle the residual PDH signal of a laser locked to a cavity, by feedforwarding it directly to the laser output field after a delay fiber. Using this straightforward method, we demonstrate a phase noise suppression capability about 4 orders of magnitude better than just using usual PDH feedback for phase noise around a few MHz. We further find that this method exhibits noise suppression performance equivalent to cavity filtering. The new method holds great promise for applications demanding highly stable lasers with diminished phase noise up to tens of MHz, e.g. precise and high-speed control of atomic and molecular quantum states.
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- 2023
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126. Deep conditional generative models for longitudinal single-slice abdominal computed tomography harmonization
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Yu, Xin, Yang, Qi, Tang, Yucheng, Gao, Riqiang, Bao, Shunxing, Cai, Leon Y., Lee, Ho Hin, Huo, Yuankai, Moore, Ann Zenobia, Ferrucci, Luigi, and Landman, Bennett A.
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Two-dimensional single-slice abdominal computed tomography (CT) provides a detailed tissue map with high resolution allowing quantitative characterization of relationships between health conditions and aging. However, longitudinal analysis of body composition changes using these scans is difficult due to positional variation between slices acquired in different years, which leading to different organs/tissues captured. To address this issue, we propose C-SliceGen, which takes an arbitrary axial slice in the abdominal region as a condition and generates a pre-defined vertebral level slice by estimating structural changes in the latent space. Our experiments on 2608 volumetric CT data from two in-house datasets and 50 subjects from the 2015 Multi-Atlas Abdomen Labeling Challenge dataset (BTCV) Challenge demonstrate that our model can generate high-quality images that are realistic and similar. We further evaluate our method's capability to harmonize longitudinal positional variation on 1033 subjects from the Baltimore Longitudinal Study of Aging (BLSA) dataset, which contains longitudinal single abdominal slices, and confirmed that our method can harmonize the slice positional variance in terms of visceral fat area. This approach provides a promising direction for mapping slices from different vertebral levels to a target slice and reducing positional variance for single-slice longitudinal analysis. The source code is available at: https://github.com/MASILab/C-SliceGen.
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- 2023
127. Investigating a Global Collapsing Hub-Filament Cloud G326.611+0.811
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He, Yu-Xin, Liu, Hong-Li, Tang, Xin-Di, Qin, Sheng-Li, Zhou, Jian-Jun, Esimbek, Jarken, Pan, Si-Rong, Li, Da-Lei, Zhao, Meng-Ke, Ji, Wei-Guang, and Komesh, Toktarkhan
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Astrophysics - Astrophysics of Galaxies - Abstract
We present the dynamics study toward the G326.611+0.811 (G326) hub-filament-system (HFS) cloud using the new APEX observations of both $^{13}$CO and C$^{18}$O (J = 2-1). The G326 HFS cloud constitutes a central hub and at least four hub-composing filaments that are divided into a major branch of filaments (F1, and F2) and a side branch (F3-F5). The cloud holds ongoing high-mass star formation as characterised by three massive dense clumps (i.e., 370-1100 $M_{\odot}$ and 0.14-0.16 g cm$^{-2}$ for C1-C3) with the high clump-averaged mass infalling rates ($>10^{-3}$ $M_{\odot}$ yr$^{-1}$) within in the major filament branch, and the associated point sources bright at 70 $\mu$m typical of young protostars. Along the five filaments, the velocity gradients are found in both $^{13}$CO and C$^{18}$O (J = 2-1) emission, suggesting that the filament-aligned gravitational collapse toward the central hub (i.e., C2) is being at work for high-mass star formation therein. Moreover, a periodic velocity oscillation along the major filament branch is revealed in both $^{13}$CO and C$^{18}$O (J = 2-1) emission with a characteristic wavelength of $\sim$3.5 pc and an amplitude of $\sim$0.31-0.38 km s$^{-1}$. We suggest that this pattern of velocity oscillation in G326 could arise from the clump-forming gas motions induced by gravitational instability. Taking into account the prevalent velocity gradients, the fragmentation of the major branch of filaments, and the ongoing collapse of the three massive dense clumps, it is indicative that G326 is a HFS undergoing global collapse., Comment: 21 pages, 13 figures, 2 tables, Accepted for publication in ApJ
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- 2023
128. Enhancing Hierarchical Transformers for Whole Brain Segmentation with Intracranial Measurements Integration
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Yu, Xin, Tang, Yucheng, Yang, Qi, Lee, Ho Hin, Bao, Shunxing, Huo, Yuankai, and Landman, Bennett A.
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Whole brain segmentation with magnetic resonance imaging (MRI) enables the non-invasive measurement of brain regions, including total intracranial volume (TICV) and posterior fossa volume (PFV). Enhancing the existing whole brain segmentation methodology to incorporate intracranial measurements offers a heightened level of comprehensiveness in the analysis of brain structures. Despite its potential, the task of generalizing deep learning techniques for intracranial measurements faces data availability constraints due to limited manually annotated atlases encompassing whole brain and TICV/PFV labels. In this paper, we enhancing the hierarchical transformer UNesT for whole brain segmentation to achieve segmenting whole brain with 133 classes and TICV/PFV simultaneously. To address the problem of data scarcity, the model is first pretrained on 4859 T1-weighted (T1w) 3D volumes sourced from 8 different sites. These volumes are processed through a multi-atlas segmentation pipeline for label generation, while TICV/PFV labels are unavailable. Subsequently, the model is finetuned with 45 T1w 3D volumes from Open Access Series Imaging Studies (OASIS) where both 133 whole brain classes and TICV/PFV labels are available. We evaluate our method with Dice similarity coefficients(DSC). We show that our model is able to conduct precise TICV/PFV estimation while maintaining the 132 brain regions performance at a comparable level. Code and trained model are available at: https://github.com/MASILab/UNesT/tree/main/wholebrainSeg.
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- 2023
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129. When 3D Bounding-Box Meets SAM: Point Cloud Instance Segmentation with Weak-and-Noisy Supervision
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Yu, Qingtao, Du, Heming, Liu, Chen, and Yu, Xin
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Learning from bounding-boxes annotations has shown great potential in weakly-supervised 3D point cloud instance segmentation. However, we observed that existing methods would suffer severe performance degradation with perturbed bounding box annotations. To tackle this issue, we propose a complementary image prompt-induced weakly-supervised point cloud instance segmentation (CIP-WPIS) method. CIP-WPIS leverages pretrained knowledge embedded in the 2D foundation model SAM and 3D geometric prior to achieve accurate point-wise instance labels from the bounding box annotations. Specifically, CP-WPIS first selects image views in which 3D candidate points of an instance are fully visible. Then, we generate complementary background and foreground prompts from projections to obtain SAM 2D instance mask predictions. According to these, we assign the confidence values to points indicating the likelihood of points belonging to the instance. Furthermore, we utilize 3D geometric homogeneity provided by superpoints to decide the final instance label assignments. In this fashion, we achieve high-quality 3D point-wise instance labels. Extensive experiments on both Scannet-v2 and S3DIS benchmarks demonstrate that our method is robust against noisy 3D bounding-box annotations and achieves state-of-the-art performance.
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- 2023
130. UV/Chlorine-BAC treatment of antidepressant drug in drinking water: efficacy, process optimization, and microbiological characterization
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Li, Xianzhong, Yan, Wanli, Li, Jianguo, Zhang, Kaiting, Ye, Chengsong, Feng, Mingbao, and Yu, Xin
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- 2024
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131. The variation of microbiological characteristics in surface waters during persistent precipitation
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Xiao, Xinyan, Chen, Chenlan, Li, Haoran, Li, Lihua, and Yu, Xin
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- 2024
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132. Analysis of Ginsenosides Rb1 and Rg1 Digestion Products in vitro Based on UHPLC-TSQ MS
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Hua-zhou NIU, Yu-xin GUO, Ting ZHOU, Hui LI, and Wei WU
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ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry (uhplc-tsq ms) ,ginsenoside rb1 ,ginsenoside rg1 ,products of digestion in vitro ,Chemistry ,QD1-999 - Abstract
A method of ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-TSQ MS) was used to study the products of protopanaxadiol ginsenoside Rb1 and protopanaxatriol ginsenoside Rg1 in simulated digestion solution in vitro for researching the digestion characteristics of ginsenoside. The resullt showed that ginsenoside Rd, Rg3, Rg5, and Rk1 are found in the digestion products of ginsenoside Rb1. In addition, ginsenoside F2 is found in the simulated intestinal juice, suggesting that it is the peculiar degradation product. Therefore, the degradation pathways of ginsenoside Rb1 are as follows: ginsenoside Rb1→ginsenoside Rd→insenoside Rg3→ginsenoside Rg5/Rk1,ginsenoside Rb1→ginsenoside Rd→ginsenoside F2. In the digestive fluids of Rg1, both F1 and Rh1 are identified. The degradation pathways of ginsenoside Rg1 are determined to be: ginsenoside Rg1→ginsenoside F1 and ginsenoside Rg1→ginsenoside Rh1. The results showed that the contents of degradation products in simulated saliva, simulated gastric juice and simulated intestinal juice change with the digestion time. The digestion products ginsenoside Rd, Rg3, Rg5 and Rk1 of ginsenoside Rb1 are the highest after 2-6 h of simulated gastric juice digestion. Ginsenoside F2 is only produced in simulated intestinal juice to digest, in simulated intestinal juice to digest after 4 h content to the maximum. In simulated intestinal fluid, the degradation products of ginsenosides Rb1 and Rg1 are the highest at 4-6 h of digestion. Ginsenoside Rg1 is degraded in the mock digest to generate F1 and Rh1. Degradation products in simulated saliva, gastric juice and intestinal juice content gradually increased, in simulated gastric juice to digest its content reached the highest after 2 h. The degradation of ginsenosides in simulated saliva is milder compared to simulated gastric juice and simulated intestinal juice. However, the degradation products in simulated gastric juice are more abundant than in simulated intestinal juice. In the process of digestion, ginsenoside Rg1 degrades more easily than Rb1. Ginsenosides Rg1 and Rb1 are hydrolyzed in the digestive tract to produce a variety of small molecular saponins, which provide an important chemical and biological basis for the development and utilization of ginsenosides.
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- 2024
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133. Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease
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Xi-xi Han, Hui-ying Zhang, Jing-wen Kong, Yu-xin Liu, Ke-ren Zhang, and Wen-ying Ren
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Maintenance hemodialysis ,Uremia ,Cardiovascular disease ,Inflammation index ,Chronic micro-inflammation ,Medicine - Abstract
Abstract Background and objectives Maintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), a common complication and leading cause of death. Persistent micro-inflammation is a unique feature of MHD. Given the established role of inflammation in the pathogenesis of atherosclerosis, this study aims to explore whether novel inflammatory markers (inflammation index) can serve as independent risk factors for CVD in MHD patients. Methods A cross-sectional survey was conducted on patients from three dialysis centers, categorized into a CVD and non-CVD group based on medical history, laboratory tests, and physical examination. Fasting blood samples were collected from all participants for indicator testing. Results The analysis of 209 patients revealed that 104 had concurrent CVD. Patients in the CVD group were significantly older and exhibited higher anxiety and depression scores. Forward stepwise multivariate logistic regression results identified the inflammation index neutrophil-to-lymphocyte ratio (NLR) (OR = 1.27, 95% CI 1.082–1.491, P
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- 2024
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134. The value of D-dimer in the prognosis of dilated cardiomyopathy: a retrospective cohort study
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Yuan Huang, Li-Hua Yang, Yu-Xin Li, Hong Chen, Jia-Hao Li, Hua-Bin Su, Chun Gui, and Qiang Su
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Dilated cardiomyopathy ,D-dimer ,All-cause mortality ,Prognosis ,Medicine ,Science - Abstract
Abstract D-dimer is a biomarker of coagulation and fibrinolytic system activation in response to the hypercoagulable state of the body. The research aimed to analyze the value of D-dimer in the prognosis of patients with dilated cardiomyopathy (DCM). Patients admitted to our center for the first time with DCM were enrolled consecutively. The clinical characteristics variables were obtained from the electronic medical record system, and the prognostic information was obtained using telephone return visits and a review of repeated hospitalization records. Univariate and multivariate Cox regression was used to explore the association of D-dimer with all-cause mortality. Smooth curve fitting, threshold saturation effect analysis, and subgroup analysis were performed. Ultimately, 534 patients were included. After a follow-up of the enrolled patients, 485 patients obtained prognostic information, of which 159 died from all causes, and the main cause of death was heart failure (89/159), the sudden death accounted for about 17%. The independent positive association between D-dimer and all-cause mortality remained unchanged in both unadjusted and adjusted Cox regression models. In the fully adjusted model, each standard deviation increase in D-dimer was associated with a 14% increase in all-cause mortality (HR = 1.14; 95% CI: 1.02 ~ 1.27; P
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- 2024
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135. FNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis in male mice
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Xin Zhang, Yi-Peng Gao, Wen-Sheng Dong, Kang Li, Yu-Xin Hu, Yun-Jia Ye, and Can Hu
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Science - Abstract
Abstract Fibronectin type III domain-containing (FNDC) proteins play critical roles in cellular homeostasis and cardiac injury, and our recent findings define FNDC5 as a promising cardioprotectant against doxorubicin- and aging-related cardiac injury. FNDC4 displays a high homology with FNDC5; however, its role and mechanism in cardiac ischemia/reperfusion (I/R) injury remain elusive. Here, we show that cardiac and plasma FNDC4 levels are elevated during I/R injury in a hypoxia-inducible factor 1α (HIF1α)-dependent manner. Cardiac-specific FNDC4 overexpression facilitates, while cardiac-specific FNDC4 knockdown inhibits cardiomyocyte survival and angiogenesis in I/R-stressed hearts of male mice through regulating the proteasomal degradation of HIF1α. Interestingly, FNDC4 does not directly stimulate angiogenesis of endothelial cells, but increases the expression and secretion of fibroblast growth factor 1 from cardiomyocytes to enhance angiogenesis in a paracrine manner. Moreover, therapeutic administration of recombinant FNDC4 protein is sufficient to alleviate cardiac I/R injury in male mice, without resulting in significant side effects. In this work, we reveal that FNDC4 alleviates cardiac I/R injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis, and define FNDC4 as a promising predictive and therapeutic target of cardiac I/R injury.
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- 2024
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136. Parental awareness on myopia prevention and control among 350 children
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Tian-Tian Li, Zi-Shui Fang, Yu-Xin Xue, Shi-Jun Chen, Ying-Xin Yang, Tie-Jun Li, Yue Yang, and Yan Wu
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myopia ,myopia prevention and control ,parental perspectives ,pre- and school-aged children ,Ophthalmology ,RE1-994 - Abstract
AIM: To understand the current situation of parental perspectives, knowledge, and practices concerning myopia prevention and control for both pre- and school-aged children. METHODS: This study was a cross-sectional survey that involved children aged 0 to 15y and their parents. Participants were required to respond to an online questionnaire by scanning a quick response (QR) code. The questionnaire consisted of 25 tick-box questions and was open to response from December 22, 2022, to January 5, 2023. The dioptric traits of the children, the visual status and educational background of the parents, the parental perspectives towards myopia and its risks, and the parents' knowledge and practices related to myopia prevention and control were recorded and measured. The Chi-square test and binomial logistic regression were used for statistics. RESULTS: Totally 350 parents responded to the questionnaire. The prevalence and severity of myopia among the surveyed children exhibited a positive correlation with advancing age (P
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- 2024
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137. NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout
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Jingwei Chi, Ying Chen, Changgui Li, Shiguo Liu, Kui Che, Zili Kong, Ziheng Guo, Yanchen Chu, Yajing Huang, Libo Yang, Cunwei Sun, Yunyang Wang, Wenshan Lv, Qing Zhang, Hui Guo, Han Zhao, Zhitao Yang, Lili Xu, Ping Wang, Bingzi Dong, Jianxia Hu, Shihai Liu, Fei Wang, Yanyun Zhao, Mengmeng Qi, Yu Xin, Huiqi Nan, Xiangzhong Zhao, Wei Zhang, Min Xiao, Ke Si, Yangang Wang, and Yihai Cao
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Cytology ,QH573-671 - Abstract
Abstract Defective renal excretion and increased production of uric acid engender hyperuricemia that predisposes to gout. However, molecular mechanisms underlying defective uric acid excretion remain largely unknown. Here, we report a rare genetic variant of gout-unprecedented NUMB gene within a hereditary human gout family, which was identified by an unbiased genome-wide sequencing approach. This dysfunctional missense variant within the conserved region of the NUMB gene (NUMBR630H) underwent intracellular redistribution and degradation through an autophagy-dependent mechanism. Mechanistically, we identified the uric acid transporter, ATP Binding Cassette Subfamily G Member 2 (ABCG2), as a novel NUMB-binding protein through its intracellular YxNxxF motif. In polarized renal tubular epithelial cells (RTECs), NUMB promoted ABCG2 trafficking towards the apical plasma membrane. Genetic loss-of-function of NUMB resulted in redistribution of ABCG2 in the basolateral domain and ultimately defective excretion of uric acid. To recapitulate the clinical situation in human gout patients, we generated a NUMBR630H knock-in mouse strain, which showed marked increases of serum urate and decreased uric acid excretion. The NUMBR630H knock-in mice exhibited clinically relevant hyperuricemia. In summary, we have uncovered a novel NUMB-mediated mechanism of uric acid excretion and a functional missense variant of NUMB in humans, which causes hyperuricemia and gout.
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- 2024
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138. S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis
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Wei-Yuan Zhang, Li Wen, Li Du, Ting Ting Liu, Yang Sun, Yi-Zhu Chen, Yu-Xin Lu, Xiao-Chen Cheng, Hui-Yan Sun, Feng-Jun Xiao, and Li-Sheng Wang
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Mesenchymal stem cells ,Engineered exosomes ,SARS-CoV-2-S-RBD ,MiR-486-5p ,Ferroptosis ,Radiation-induced pulmonary injury ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Background Radiation-induced lung injury (RILI) is associated with alveolar epithelial cell death and secondary fibrosis in injured lung. Mesenchymal stem cell (MSC)-derived exosomes have regenerative effect against lung injury and the potential to intervene of RILI. However, their intervention efficacy is limited because they lack lung targeting characters and do not carry sufficient specific effectors. SARS-CoV-2 spike glycoprotein (SARS-CoV-2-S-RBD) binds angiotensin-converting enzyme 2 (ACE2) receptor and mediates interaction with host cells. MiR-486-5p is a multifunctional miRNA with angiogenic and antifibrotic potential and acts as an effector in MSC-derived exosomes. Ferroptosis is a form of cell death associated with radiation injury, its roles and mechanisms in RILI remain unclear. In this study, we developed an engineered MSC-derived exosomes with SARS-CoV-2-S-RBD- and miR-486-5p- modification and investigated their intervention effects on RIPF and action mechanisms via suppression of epithelial cell ferroptosis. Results Adenovirus-mediated gene modification led to miR-486-5p overexpression in human umbilical cord MSC exosomes (p
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- 2024
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139. High-Entropy Engineering in Hollow Layered Hydroxide Arrays to Boost 5‑Hydroxymethylfurfural Electrooxidation by Suppressing Oxygen Evolution
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Yu Xin, Hongchuan Fu, Liyu Chen, Yongfei Ji, Yingwei Li, and Kui Shen
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Chemistry ,QD1-999 - Published
- 2024
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140. Potential cardiac-derived exosomal miRNAs involved in cardiac healing and remodeling after myocardial ischemia–reperfusion injury
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Yu Liu, Jiao Chen, Jian Xiong, Jin-Qun Hu, Li-Yuan Yang, Yu-Xin Sun, Ying Wei, Yi Zhao, Xiao Li, Qian-Hua Zheng, Wen-Chuan Qi, and Fan-Rong Liang
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Myocardial ischemia‒reperfusion injury ,Exosomal miRNA ,Cell migration ,Locomotion ,Medicine ,Science - Abstract
Abstract Migratory cells exist in the heart, such as immune cells, fibroblasts, endothelial cells, etc. During myocardium injury, such as ischemia–reperfusion (MIRI), cells migrate to the site of injury to perform repair functions. However, excessive aggregation of these cells may exacerbate damage to the structure and function of the heart, such as acute myocarditis and myocardial fibrosis. Myocardial injury releases exosomes, which are a type of vesicle with signal transduction function and the miRNA carried by exosomes can control cell migration function. Therefore, regulating this migratory cell population through cardiac-derived exosomal miRNA is crucial for protecting and maintaining cardiac function. Through whole transcriptome RNA sequencing, exosomal miRNA sequencing and single-cell dataset analysis, we (1) determined the potential molecular regulatory role of the lncRNA‒miRNA‒mRNA axis in MIRI, (2) screened four important exosomal miRNAs that could be released by cardiac tissue, and (3) screened seven genes related to cell locomotion that are regulated by four miRNAs, among which Tradd and Ephb6 may be specific for promoting migration of different cells of myocardial tissue in myocardial infarct. We generated a core miRNA‒mRNA network based on the functions of the target genes, which may be not only a target for cardiac repair but also a potential diagnostic marker for interactions between the heart and other tissues or organs. In conclusion, we elucidated the potential mechanism of MIRI in cardiac remodeling from the perspective of cell migration, and inhibition of cellular overmigration based on this network may provide new therapeutic targets for MIRI and to prevent MIRI from developing into other diseases.
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- 2024
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141. Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota
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Lin Chen, Yu-Xin Xu, Yuan-Shuo Wang, Ying-Ying Ren, Xue-Man Dong, Pu Wu, Tian Xie, Qi Zhang, and Jian-Liang Zhou
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Prostate cancer ,Tumor microenvironment ,Immune cells ,Vascular system ,Stromal cells ,Microbiota ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Prostate cancer (PCa) is one of the most prevalent malignancies in males worldwide. Increasing research attention has focused on the PCa microenvironment, which plays a crucial role in tumor progression and therapy resistance. This review aims to provide a comprehensive overview of the key components of the PCa microenvironment, including immune cells, vascular systems, stromal cells, and microbiota, and explore their implications for diagnosis and treatment. Methods Keywords such as “prostate cancer”, “tumor microenvironment”, “immune cells”, “vascular system”, “stromal cells”, and “microbiota” were used for literature retrieval through online databases including PubMed and Web of Science. Studies related to the PCa microenvironment were selected, with a particular focus on those discussing the roles of immune cells, vascular systems, stromal cells, and microbiota in the development, progression, and treatment of PCa. The selection criteria prioritized peer-reviewed articles published in the last five years, aiming to summarize and analyze the latest research advancements and clinical relevance regarding the PCa microenvironment. Results The PCa microenvironment is highly complex and dynamic, with immune cells contributing to immunosuppressive conditions, stromal cells promoting tumor growth, and microbiota potentially affecting androgen metabolism. Vascular systems support angiogenesis, which fosters tumor expansion. Understanding these components offers insight into the mechanisms driving PCa progression and opens avenues for novel therapeutic strategies targeting the tumor microenvironment. Conclusions A deeper understanding of the PCa microenvironment is crucial for advancing diagnostic techniques and developing precision therapies. This review highlights the potential of targeting the microenvironment to improve patient outcomes, emphasizing its significance in the broader context of PCa research and treatment innovation. Graphical Abstract
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- 2024
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142. Family burden and psychological distress among Chinese caregivers of elderly people with dementia: a moderated mediation model
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Yi-xin Wang, Chan Cai, Yu-xin Zhu, Wen-li Shi, Bing Cheng, Chen-yang Li, and Chong-qing Shi
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Dementia ,Informal caregivers ,Burden ,Psychological distress ,Coping resources ,Nursing ,RT1-120 - Abstract
Abstract Background Although the Stress-Coping Model (SCM) has been widely used to explain the coping process of individuals facing stressful situations, its applicability to caregivers of elderly people with dementia (PwD) in China needs to be further investigated. Furthermore, the role of external resources in caregivers stress coping is not yet clear. Therefore, our study aimed to investigated the mediating and moderating mechanisms between family burden and psychological distress in PwD caregivers based on the SCM. Methods A cross-sectional study, with 193 pairs of PwD and caregivers completed the self-designed questionnaire, Family Burden Scale of Disease, Kessler Psychological Distress Scale, General Self-Efficacy Scale, Simplified Coping Style Question, The Family Adaptation and Cohesion Evaluation Scales II-CV and Social Support Rating Scale. Partial least squares-structural equation modeling (PLS-SEM) analyzed the mediating and moderating effects. Results Family burden positively correlated with psychological distress; the chain mediation effects of self-efficacy and positive coping between family burden and psychological distress was significant; the interaction term (family function_positive coping) did not but (social support_positive coping) had a significant positive impact on psychological distress. Conclusions The findings provides a practical basis for the use of SCM in informal caregivers of elderly PwD, assists understanding the mechanism of the relationship between family burden and psychological distress. And it supplies new perspectives for reducing the negative psychological health status and a theoretical basis for designing interventions for caregivers.
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- 2024
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143. Multimodal apparent diffusion MRI model in noninvasive evaluation of breast cancer and Ki-67 expression
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Huan Chang, Jinming Chen, Dawei Wang, Hongxia Li, Lei Ming, Yuting Li, Dan Yu, Yu Xin Yang, Peng Kong, Wenjing Jia, Qingqing Yan, Xinhui Liu, and Qingshi Zeng
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Diffusion magnetic resonance imaging ,Breast cancer ,Multimodal apparent diffusion analysis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background To assess the capability of multimodal apparent diffusion (MAD) weighted magnetic resonance imaging (MRI) to distinguish between malignant and benign breast lesions, and to predict Ki-67 expression level in breast cancer. Methods This retrospective study was conducted with 93 patients who had postoperative pathology-confirmed breast cancer or benign breast lesions. MAD images were acquired using a 3.0 T MRI scanner with 16 b values. The MAD parameters, as flow (fF, DF), unimpeded (fluid) (fUI), hindered (fH, DH, and αH), and restricted (fR, DR), were calculated. The differences of the parameters were compared by Mann–Whitney U test between the benign/malignant lesions and high/low Ki-67 expression level. The diagnostic performance was assessed by the area under the receiver operating characteristic curve (AUC). Results The fR in the malignant lesions was significantly higher than in the benign lesions (P = 0.001), whereas the fUI and DH were found to be significantly lower (P = 0.007 and P
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- 2024
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144. CD276 is a promising biomarker for the prognosis of clear cell renal cell carcinoma
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Yan‐Hang Yu, Jian‐Hao Xu, Hao Chen, Yu‐Xin Lin, Jun Ou‐Yang, and Zhi‐Yu Zhang
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CD276 ,clear cell renal cell carcinoma ,nomogram ,progression‐free interval ,tumor diameter ,Medicine (General) ,R5-920 - Abstract
Abstract This study aimed to investigate the role of cluster of differentiation 276 (CD276) in evaluating the prognosis of clear cell renal carcinoma (ccRCC) and to build a nomogram for predicting ccRCC progression post‐surgery. Using data downloaded from The Cancer Genome Atlas (TCGA) database, we constructed a Kaplan–Meier (KM) curve depicting the relationship between CD276 expression levels and the progression‐free interval (PFI) in 539 ccRCC cases. We further validated this by plotting a KM curve of the relationship between CD276 expression levels and PFI in 116 ccRCC patients from our hospital. Using clinical data collected from 116 patients, we identified independent risk factors affecting postoperative PFI in patients with ccRCC through univariate and multivariate COX analyses and created a nomogram for visual representation. Both TCGA and clinical data revealed a negative correlation between the expression levels of CD276 and PFI (p
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- 2024
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145. An early and stable mouse model of polymyxin-induced acute kidney injury
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Linqiong Liu, Yuxi Liu, Yu Xin, Yanqi Liu, Yan Gao, Kaijiang Yu, and Changsong Wang
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Polymyxin B ,Polymyxin E ,AKI ,Mouse model ,GFR ,KIM-1 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Polymyxins have been revived as a last-line therapeutic option for multi-drug resistant bacteria and continue to account for a significant proportion of global antibiotic usage. However, kidney injury is often a treatment limiting event with kidney failure rates ranging from 5 to 13%. The mechanisms underlying polymyxin-induced nephrotoxicity are currently unclear. Researches of polymyxin-associated acute kidney injury (AKI) models need to be more standardized, which is crucial for obtaining consistent and robust mechanistic results. Methods In this study, male C57BL/6 mice received different doses of polymyxin B (PB) and polymyxin E (PE, also known as colistin) by different routes once daily (QD), twice daily (BID), and thrice daily (TID) for 3 days. We continuously monitored the glomerular filtration rate (GFR) and the AKI biomarkers, including serum creatinine (Scr), blood urea nitrogen (BUN), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1). We also performed histopathological examinations to assess the extent of kidney injury. Results Mice receiving PB (35 mg/kg/day subcutaneously) once daily exhibited a significant decrease in GFR and a notable increase in KIM-1 two hours after the first dose. Changes in GFR and KIM-1 at 24, 48 and 72 h were consistent and demonstrated the occurrence of kidney injury. Histopathological assessments showed a positive correlation between the severity of kidney injury and the changes in GFR and KIM-1 (Spearman’s rho = 0.3167, P = 0.0264). The other groups of mice injected with PB and PE did not show significant changes in GFR and AKI biomarkers compared to the control group. Conclusion The group receiving PB (35 mg/kg/day subcutaneously) once daily consistently developed AKI at 2 h after the first dose. Establishing an early and stable AKI model facilitates researches into the mechanisms of early-stage kidney injury. In addition, our results indicated that PE had less toxicity than PB and mice receiving the same dose of PB in the QD group exhibited more severe kidney injury than the BID and TID groups.
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- 2024
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146. Crystal structure of poly[(μ4-(3-amino-1H-1,2,4-triazol-1-yl)benzene-1,3-dicarboxylato-κ4N:O:O':O')(1-methylpyrroldin-2-one-κ1O)dicopper(II)] – 1-methylpyrroldin-2-one (1/3), C40H48Cu2N12O12
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Xia Yu-Pei and Huang Yu-Xin
- Subjects
2325277 ,Physics ,QC1-999 ,Crystallography ,QD901-999 - Abstract
C40H48Cu2N12O12, monoclinic, P21/n (no. 14), a = 10.9519(1) Å, b = 17.4351(2) Å, c = 24.4288(3) Å, β = 102.143(1)°, V = 4560.25(9) Å3, Z = 4, Rgt(F) = 0.0647, wRref(F2) = 0.1904, T = 120 K.
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- 2024
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147. Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models
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Yu Xin, Yanqi Liu, Linqiong Liu, Xinran Wang, Dawei Wang, Yuchen Song, Lifeng Shen, Yuxi Liu, Yuhan Liu, Yahui Peng, Xibo Wang, Yang Zhou, Hongxu Li, Yuxin Zhou, Pengfei Huang, Mengyao Yuan, Yu Xiao, Kaijiang Yu, and Changsong Wang
- Subjects
Acute kidney injury ,Real time glomerular filtration rate ,Sepsis ,Ischemia reperfusion ,Cisplatin ,Folic acid ,Medicine - Abstract
Abstract In this study, we dynamically monitored the glomerular filtration rate and other assessment of renal function and markers of injury in various mice models of acute kidney injury. Male C57BL/6 mice were utilized to establish acute kidney injury models of sepsis, ischemia reperfusion, cisplatin, folic acid, aristolochic acid and antibiotic. In addition to the real time glomerular filtration rate, renal LCN-2 and HAVCR-1 mRNA expression levels, and serum creatinine, urea nitrogen and cystatin c levels were also used to evaluate renal function. In addition, the protein levels of LCN-2 and HAVCR-1 in renal, serum and urine were measured. Our results demonstrated that the changes in biomarkers always lagged the real time glomerular filtration rate during the progression and recovery of renal injury. Cystatin-c can reflect renal injury earlier than other markers, but it remains higher in the recovery stage. Perhaps the glomerular filtration rate does not reflect the greater injury caused by vancomycin plus piperacillin.
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- 2024
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148. Lee–Yang edge singularities in QCD via the Dyson–Schwinger equations
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Zi-Yan Wan, Yi Lu, Fei Gao, and Yu-xin Liu
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract We take the Dyson–Schwinger Equation approach of QCD for the quark propagator at complex chemical potential to study the QCD phase transition. The phase transition line of the $$(2+1)$$ ( 2 + 1 ) -flavor QCD matter in the imaginary chemical potential region is computed via a simplified truncation scheme, whose curvature is found to be consistent with the one at real chemical potential. Moreover, the computation in the complex chemical potential plane allows us to determine the location of the Lee–Yang edge singularities. We show explicitly that the critical end point coincides with the Lee–Yang edge singularities on the real $$\mu _{B} $$ μ B axis. We also investigate the scaling behavior of the singularities and discuss the possibility of extrapolating the CEP from a certain range of chemical potential.
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- 2024
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149. Entanglement phase transition due to reciprocity breaking without measurement or post-selection
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Lee, Gideon, Jin, Tony, Wang, Yu-Xin, McDonald, Alexander, and Clerk, Aashish
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Statistical Mechanics - Abstract
Despite its fully unitary dynamics, the bosonic Kitaev chain (BKC) displays key hallmarks of non-Hermitian physics including non-reciprocal transport and the non-Hermitian skin effect. Here we demonstrate another remarkable phenomena: the existence of an entanglement phase transition (EPT) in a variant of the BKC that occurs as a function of a Hamiltonian parameter g, and which coincides with a transition from a reciprocal to a non-reciprocal phase. As g is reduced below a critical value, the post-quench entanglement entropy of a subsystem of size l goes from a volume-law phase where it scales as l to a super-volume law phase where it scales like lN with N the total system size. This EPT occurs for a system undergoing purely unitary evolution and does not involve measurements, post-selection, disorder or dissipation. We derive analytically the entanglement entropy out of and at the critical point for the $l=1$ and $l/N \ll 1$ case.
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- 2023
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150. EfficientDreamer: High-Fidelity and Robust 3D Creation via Orthogonal-view Diffusion Prior
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Hu, Zhipeng, Zhao, Minda, Zhao, Chaoyi, Liang, Xinyue, Li, Lincheng, Zhao, Zeng, Fan, Changjie, Zhou, Xiaowei, and Yu, Xin
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Computer Science - Computer Vision and Pattern Recognition - Abstract
While image diffusion models have made significant progress in text-driven 3D content creation, they often fail to accurately capture the intended meaning of text prompts, especially for view information. This limitation leads to the Janus problem, where multi-faced 3D models are generated under the guidance of such diffusion models. In this paper, we propose a robust high-quality 3D content generation pipeline by exploiting orthogonal-view image guidance. First, we introduce a novel 2D diffusion model that generates an image consisting of four orthogonal-view sub-images based on the given text prompt. Then, the 3D content is created using this diffusion model. Notably, the generated orthogonal-view image provides strong geometric structure priors and thus improves 3D consistency. As a result, it effectively resolves the Janus problem and significantly enhances the quality of 3D content creation. Additionally, we present a 3D synthesis fusion network that can further improve the details of the generated 3D contents. Both quantitative and qualitative evaluations demonstrate that our method surpasses previous text-to-3D techniques. Project page: https://efficientdreamer.github.io.
- Published
- 2023
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