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421 results on '"Yoshimi, Akira"'

101. Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

Author

Kushima, Itaru, primary, Aleksic, Branko, additional, Nakatochi, Masahiro, additional, Shimamura, Teppei, additional, Okada, Takashi, additional, Uno, Yota, additional, Morikawa, Mako, additional, Ishizuka, Kanako, additional, Shiino, Tomoko, additional, Kimura, Hiroki, additional, Arioka, Yuko, additional, Yoshimi, Akira, additional, Takasaki, Yuto, additional, Yu, Yanjie, additional, Nakamura, Yukako, additional, Yamamoto, Maeri, additional, Iidaka, Tetsuya, additional, Iritani, Shuji, additional, Inada, Toshiya, additional, Ogawa, Nanayo, additional, Shishido, Emiko, additional, Torii, Youta, additional, Kawano, Naoko, additional, Omura, Yutaka, additional, Yoshikawa, Toru, additional, Uchiyama, Tokio, additional, Yamamoto, Toshimichi, additional, Ikeda, Masashi, additional, Hashimoto, Ryota, additional, Yamamori, Hidenaga, additional, Yasuda, Yuka, additional, Someya, Toshiyuki, additional, Watanabe, Yuichiro, additional, Egawa, Jun, additional, Nunokawa, Ayako, additional, Itokawa, Masanari, additional, Arai, Makoto, additional, Miyashita, Mitsuhiro, additional, Kobori, Akiko, additional, Suzuki, Michio, additional, Takahashi, Tsutomu, additional, Usami, Masahide, additional, Kodaira, Masaki, additional, Watanabe, Kyota, additional, Sasaki, Tsukasa, additional, Kuwabara, Hitoshi, additional, Tochigi, Mamoru, additional, Nishimura, Fumichika, additional, Yamasue, Hidenori, additional, Eriguchi, Yosuke, additional, Benner, Seico, additional, Kojima, Masaki, additional, Yassin, Walid, additional, Munesue, Toshio, additional, Yokoyama, Shigeru, additional, Kimura, Ryo, additional, Funabiki, Yasuko, additional, Kosaka, Hirotaka, additional, Ishitobi, Makoto, additional, Ohmori, Tetsuro, additional, Numata, Shusuke, additional, Yoshikawa, Takeo, additional, Toyota, Tomoko, additional, Yamakawa, Kazuhiro, additional, Suzuki, Toshimitsu, additional, Inoue, Yushi, additional, Nakaoka, Kentaro, additional, Goto, Yu-ichi, additional, Inagaki, Masumi, additional, Hashimoto, Naoki, additional, Kusumi, Ichiro, additional, Son, Shuraku, additional, Murai, Toshiya, additional, Ikegame, Tempei, additional, Okada, Naohiro, additional, Kasai, Kiyoto, additional, Kunimoto, Shohko, additional, Mori, Daisuke, additional, Iwata, Nakao, additional, and Ozaki, Norio, additional

Published
2018
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103. Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

Author

Mouri, Akihiro, primary, Ukai, Mayu, additional, Uchida, Mizuki, additional, Hasegawa, Sho, additional, Taniguchi, Masayuki, additional, Ito, Takahiro, additional, Hida, Hirotake, additional, Yoshimi, Akira, additional, Yamada, Kiyofumi, additional, Kunimoto, Shohko, additional, Ozaki, Norio, additional, Nabeshima, Toshitaka, additional, and Noda, Yukihiro, additional

Published
2018
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108. Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders

Author

Ishizuka, Kanako, primary, Tabata, Hidenori, additional, Ito, Hidenori, additional, Kushima, Itaru, additional, Noda, Mariko, additional, Yoshimi, Akira, additional, Usami, Masahide, additional, Watanabe, Kyota, additional, Morikawa, Mako, additional, Uno, Yota, additional, Okada, Takashi, additional, Mori, Daisuke, additional, Aleksic, Branko, additional, Ozaki, Norio, additional, and Nagata, Koh-ichi, additional

Published
2017
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109. MOESM1 of Expression of ustR and the Golgi protease KexB are required for ustiloxin B biosynthesis in Aspergillus oryzae

Author

Yoshimi, Akira, Myco Umemura, Nagano, Nozomi, Koike, Hideaki, Machida, Masayuki, and Keietsu Abe

Subjects
food and beverages
Abstract

Additional file 1:Table S1. PCR primers used in this study. Figure S1. Expression of the genes of the cluster for ustiloxin B biosynthesis in A. oryzae wild-type (RIB40) and ustR EX (G101 and G301) strains grown for 1 day. Figure S2. Expression of the genes of the cluster for ustiloxin B biosynthesis in A. oryzae wild-type (RIB40) and ustR EX (G101 and G301) strains grown for 3 day. Figure S3. Expression of the genes of the cluster for ustiloxin B biosynthesis in A. oryzae wild-type (RIB40) and ustR EX (G101 and G301) strains grown for 7 day. Figure S4. Expression of the genes of the cluster for ustiloxin B biosynthesis in the A. oryzae strains ∆kexB, ustR EX/∆kexB, NSlD-∆P10 (∆P10), and ustR EX/∆P10.

Published
2016
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111. Mitogen-activated protein kinases MpkA and MpkB independently affect micafungin sensitivity in Aspergillus nidulans

Author

Yoshimi, Akira, Fujioka, Tomonori, Mizutani, Osamu, Marui, Junichiro, Hagiwara, Daisuke, and Keietsu Abe

Abstract

The transcriptional regulation of the MAPK mpkA and cell wall-related genes in Aspergillus nidulans differs from that of their counterparts in Saccharomyces cerevisiae. The A. nidulans MAPK MpkB is putatively orthologous to the yeast MAPKs Kss1p and Fus3p. To investigate MpkB and its contribution to cell wall integrity in A. nidulans, we constructed mpkB-disruptant (mpkB∆) strains. We previously showed that mpkA∆ strains exhibited reduced colony growth and increased sensitivity to the β-1,3-glucan synthase inhibitor micafungin. Like mpkA∆ strains, mpkB∆ strains exhibited slight growth retardation and increased sensitivity to micafungin. Although MpkB-dependent signaling modulated the transcription of some cell wall-related genes, the sugar composition of cell wall fractions was similar among wild-type, mpkA∆, and mpkB∆ strains. To elucidate the relationship between MpkA and MpkB pathways, we compared conditional mutants of mpkB with those with mpkA deletion. Sensitivity testing suggested that MpkA and MpkB additively contribute to micafungin activity in A. nidulans.

Published
2015
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112. Analysis of the self-assembly process of Aspergillus oryzaehydrophobin RolA by Langmuir–Blodgett method

Author

Terauchi, Yuki, Tanaka, Takumi, Mitsuishi, Masaya, Yabu, Hiroshi, Yoshimi, Akira, Nantani, Kei, and Abe, Keietsu

Abstract

ABSTRACTHydrophobins are small, amphipathic proteins secreted by filamentous fungi. Hydrophobin RolA, which is produced by Aspergillus oryzae, attaches to solid surfaces, recruits the polyesterase CutL1, and consequently promotes hydrolysis of polyesters. Because this interaction requires the N-terminal, positively charged residue of RolA to be exposed on the solid surface, the orientation of RolA on the solid surface is important for recruitment. However, the process by which RolA forms the self-assembled structure at the interface remains unclear. Using the Langmuir–Blodgett technique, we analyzed the process by which RolA forms a self-assembled structure at the air–water interface and observed the structures on the hydrophobic or hydrophilic SiO2substrates via atomic force microscopy. We found that RolA formed self-assembled films in two steps during phase transitions. We observed different assembled structures of RolA on hydrophilic and hydrophobic SiO2substrates.

Published
2020
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114. Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population

Author

Takasaki, Yuto, primary, Koide, Takayoshi, additional, Wang, Chenyao, additional, Kimura, Hiroki, additional, Xing, Jingrui, additional, Kushima, Itaru, additional, Ishizuka, Kanako, additional, Mori, Daisuke, additional, Sekiguchi, Mariko, additional, Ikeda, Masashi, additional, Aizawa, Miki, additional, Tsurumaru, Naoko, additional, Iwayama, Yoshimi, additional, Yoshimi, Akira, additional, Arioka, Yuko, additional, Yoshida, Mami, additional, Noma, Hiromi, additional, Oya-Ito, Tomoko, additional, Nakamura, Yukako, additional, Kunimoto, Shohko, additional, Aleksic, Branko, additional, Uno, Yota, additional, Okada, Takashi, additional, Ujike, Hiroshi, additional, Egawa, Jun, additional, Kuwabara, Hitoshi, additional, Someya, Toshiyuki, additional, Yoshikawa, Takeo, additional, Iwata, Nakao, additional, and Ozaki, Norio, additional

Published
2016
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119. Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders

Author

Xing, Jingrui, primary, Kimura, Hiroki, additional, Wang, Chenyao, additional, Ishizuka, Kanako, additional, Kushima, Itaru, additional, Arioka, Yuko, additional, Yoshimi, Akira, additional, Nakamura, Yukako, additional, Shiino, Tomoko, additional, Oya-Ito, Tomoko, additional, Takasaki, Yuto, additional, Uno, Yota, additional, Okada, Takashi, additional, Iidaka, Tetsuya, additional, Aleksic, Branko, additional, Mori, Daisuke, additional, and Ozaki, Norio, additional

Published
2016
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120. Class of cyclic ribosomal peptide synthetic genes in filamentous fungi

Author

Nagano, Nozomi, primary, Umemura, Myco, additional, Izumikawa, Miho, additional, Kawano, Jin, additional, Ishii, Tomoko, additional, Kikuchi, Moto, additional, Tomii, Kentaro, additional, Kumagai, Toshitaka, additional, Yoshimi, Akira, additional, Machida, Masayuki, additional, Abe, Keietsu, additional, Shin-ya, Kazuo, additional, and Asai, Kiyoshi, additional

Published
2016
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121. An Analysis of Behavioral and Genetic Risk Factors for Chemotherapy-Induced Nausea and Vomiting in Japanese Subjects

Author

Mukoyama, Naoki, primary, Yoshimi, Akira, additional, Goto, Aya, additional, Kotani, Haruka, additional, Ishikawa, Kazuhiro, additional, Miyazaki, Noriko, additional, Miyazaki, Masayuki, additional, Yamada, Kiyofumi, additional, Kikkawa, Fumitaka, additional, Hasegawa, Yoshinori, additional, Ozaki, Norio, additional, and Noda, Yukihiro, additional

Published
2016
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122. Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population

Author

Kimura, Hiroki, primary, Tanaka, Satoshi, additional, Kushima, Itaru, additional, Koide, Takayoshi, additional, Banno, Masahiro, additional, Kikuchi, Tsutomu, additional, Nakamura, Yukako, additional, Shiino, Tomoko, additional, Yoshimi, Akira, additional, Oya-Ito, Tomoko, additional, Xing, Jingrui, additional, Wang, Chenyao, additional, Takasaki, Yuto, additional, Aleksic, Branko, additional, Okada, Takashi, additional, Ikeda, Masashi, additional, Inada, Toshiya, additional, Iidaka, Tetsuya, additional, Iwata, Nakao, additional, and Ozaki, Norio, additional

Published
2015
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124. Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders

Author

Xing, Jingrui, primary, Wang, Chenyao, additional, Kimura, Hiroki, additional, Takasaki, Yuto, additional, Kunimoto, Shohko, additional, Yoshimi, Akira, additional, Nakamura, Yukako, additional, Koide, Takayoshi, additional, Banno, Masahiro, additional, Kushima, Itaru, additional, Uno, Yota, additional, Okada, Takashi, additional, Aleksic, Branko, additional, Ikeda, Masashi, additional, Iwata, Nakao, additional, and Ozaki, Norio, additional

Published
2014
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125. Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility

Author

Kimura, Hiroki, primary, Tsuboi, Daisuke, additional, Wang, Chenyao, additional, Kushima, Itaru, additional, Koide, Takayoshi, additional, Ikeda, Masashi, additional, Iwayama, Yoshimi, additional, Toyota, Tomoko, additional, Yamamoto, Noriko, additional, Kunimoto, Shohko, additional, Nakamura, Yukako, additional, Yoshimi, Akira, additional, Banno, Masahiro, additional, Xing, Jingrui, additional, Takasaki, Yuto, additional, Yoshida, Mami, additional, Aleksic, Branko, additional, Uno, Yota, additional, Okada, Takashi, additional, Iidaka, Tetsuya, additional, Inada, Toshiya, additional, Suzuki, Michio, additional, Ujike, Hiroshi, additional, Kunugi, Hiroshi, additional, Kato, Tadafumi, additional, Yoshikawa, Takeo, additional, Iwata, Nakao, additional, Kaibuchi, Kozo, additional, and Ozaki, Norio, additional

Published
2014
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129. Functional Analysis of the α-1,3-Glucan Synthase Genes agsA and agsB in Aspergillus nidulans: AgsB Is the Major α-1,3-Glucan Synthase in This Fungus

Author

Yoshimi, Akira, primary, Sano, Motoaki, additional, Inaba, Azusa, additional, Kokubun, Yuko, additional, Fujioka, Tomonori, additional, Mizutani, Osamu, additional, Hagiwara, Daisuke, additional, Fujikawa, Takashi, additional, Nishimura, Marie, additional, Yano, Shigekazu, additional, Kasahara, Shin, additional, Shimizu, Kiminori, additional, Yamaguchi, Masashi, additional, Kawakami, Kazuyoshi, additional, and Abe, Keietsu, additional

Published
2013
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131. Analysis of the VAV3 as Candidate Gene for Schizophrenia: Evidences From Voxel-Based Morphometry and Mutation Screening

Author

Aleksic, Branko, primary, Kushima, Itaru, additional, Hashimoto, Ryota, additional, Ohi, Kazutaka, additional, Ikeda, Masashi, additional, Yoshimi, Akira, additional, Nakamura, Yukako, additional, Ito, Yoshihito, additional, Okochi, Tomo, additional, Fukuo, Yasuhisa, additional, Yasuda, Yuka, additional, Fukumoto, Motoyuki, additional, Yamamori, Hidenaga, additional, Ujike, Hiroshi, additional, Suzuki, Michio, additional, Inada, Toshiya, additional, Takeda, Masatoshi, additional, Kaibuchi, Kozo, additional, Iwata, Nakao, additional, and Ozaki, Norio, additional

Published
2012
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133. Reliability and Validity of the Japanese Version of BEMIB Modified for Patients With Bipolar Disorder: a Self-rating Scale for Medication Adherence

Author

Tokura, Tatsuya, primary, Kimura, Hiroyuki, additional, Yoshimi, Akira, additional, Ohashi, Mitsuki, additional, Masuda, Mie, additional, Senzaki, Koji, additional, Yoshida, Keizo, additional, Aleksic, Branko, additional, Noda, Yukihiro, additional, Yamada, Kiyofumi, additional, and Ozaki, Norio, additional

Published
2012
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136. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems

Author

Noda, Yukihiro, primary, Mouri, Akihiro, additional, Ando, Yu, additional, Waki, Yukari, additional, Yamada, Shin-nosuke, additional, Yoshimi, Akira, additional, Yamada, Kiyofumi, additional, Ozaki, Norio, additional, Wang, Dayong, additional, and Nabeshima, Toshitaka, additional

Published
2010
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142. Practical Clinical Pharmacy Training through Cooperation between Medical and Pharmaceutical Schools: Resident Faculty-led Practical Training Employing "Age-mixing Method"

Author

Kato, Hiroshi, primary, Kurata, Yoko, additional, Kishi, Rina, additional, Kondo, Sumiyo, additional, Yoshimi, Akira, additional, Kawamura, Yukiko, additional, Fukushima, Kuriko, additional, Mizuno, Tomohiro, additional, Waki, Yukari, additional, Ito, Tatsuo, additional, Yamada, Kiyofumi, additional, Nabeshima, Toshitaka, additional, and Noda, Yukihiro, additional

Published
2009
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143. KAGAKU TO SEIBUTSU

Author

TANAKA, Chihiro, primary, IZUMITSU, Kosuke, additional, YOSHIMI, Akira, additional, SHIMIZU, Kiminori, additional, KIMURA, Makoto, additional, and MOTOYAMA, Takayuki, additional

Published
2009
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144. KAGAKU TO SEIBUTSU

Author

NISHIMURA, Marie, primary, FUJIKAWA, Takashi, additional, YOSHIMI, Akira, additional, and ABE, Keietsu, additional

Published
2009
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150. Increased enzyme production under liquid culture conditions in the industrial fungus Aspergillus oryzaeby disruption of the genes encoding cell wall α-1,3-glucan synthase

Author

Miyazawa, Ken, Yoshimi, Akira, Zhang, Silai, Sano, Motoaki, Nakayama, Mayumi, Gomi, Katsuya, and Abe, Keietsu

Abstract

Under liquid culture conditions, the hyphae of filamentous fungi aggregate to form pellets, which reduces cell density and fermentation productivity. Previously, we found that loss of α-1,3-glucan in the cell wall of the fungus Aspergillus nidulansincreased hyphal dispersion. Therefore, here we constructed a mutant of the industrial fungus A. oryzaein which the three genes encoding α-1,3-glucan synthase were disrupted (tripleΔ). Although the hyphae of the tripleΔ mutant were not fully dispersed, the mutant strain did form smaller pellets than the wild-type strain. We next examined enzyme productivity under liquid culture conditions by transforming the cutinase-encoding gene cutL1into A. oryzaewild-type and the tripleΔ mutant (i.e. wild-type-cutL1, tripleΔ-cutL1). A. oryzaetripleΔ-cutL1 formed smaller hyphal pellets and showed both greater biomass and increased CutL1 productivity compared with wild-type-cutL1, which might be attributable to a decrease in the number of tripleΔ-cutL1 cells under anaerobic conditions.

Published
2016
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