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Rolling shear modulus and strength are the key factors affecting the mechanical performance of some wood products such as cross-laminated timber (CLT). As reported, rolling shear property strongly depends on the sawing pattern such as the aspect ratio and grain direction (grain mode). However, the mechanism behind this phenomenon has not yet been clarified. In this work, the rolling shear modulus and strength of spruce-pine-fir (SPF) with different grain modes and aspect ratios were experimentally investigated. In addition, a theoretical investigation was carried out to reveal the mechanism behind this phenomenon. The results exhibited that the rolling shear moduli of 0° and 90° grain-mode wood were the same. This value can be called the pure rolling shear modulus. Rolling shear modulus of wood with angles other than 0° and 90° can be calculated from the pure rolling shear modulus and grain angle. Therefore, this modulus can be called the apparent rolling shear modulus. Thus, using 0° and 90° grain-mode specimens to determine the pure rolling shear modulus and strength of wood is recommended.

Scene text detection, this task of detecting text from real images, is a hot research topic in the machine vision community. Most of the current research is based on an anchor box. These methods are complex in model design and time-consuming to train. In this paper, we propose a new Fully Convolutional One-Stage Object Detection (FCOS)-based text detection method that can robustly detect multioriented and multilingual text from natural scene images in a per pixel prediction approach. Our proposed text detector employs an anchor-free approach, unlike state-of-the-art text detectors that do not rely on a predefined anchor box. In order to enhance the feature representation ability of FCOS for text detection tasks, we apply the Bidirectional Feature Pyramid Network (BiFPN) as the backbone network, enhancing the model learning capacity and increasing the receptive field. We demonstrate the superior performance of our method on multioriented (ICDAR-2015, ICDAR-2017 MLT) and horizontal (ICDAR-2013) text detection benchmark tasks. Moreover, our method has an f-measure of 88.65 and 86.32 for the benchmark datasets ICDAR 2013 and ICDAR 2015, respectively, and 80.75 for the ICDAR-2017 MLT dataset.

Traditional rigid robot application in the medical field is limited due to the limited degrees of freedom caused by their material and structure. Inspired by trunk, tentacles, and snakes, continuum robot (CR) could traverse confined space, manipulate objects in complex environment, and conform to curvilinear paths in space. The continuum robot has broad prospect in surgery due to its high dexterity, which can reach circuitous areas of the body and perform precision surgery. Recently, many efforts have been done by researchers to improve the design and actuation methods of continuum robots. Several continuum robots have been applied in clinic surgical interventions and demonstrated superiorities to conventional rigid-link robots. In this paper, we provide an overview of the current development of continuum robots, including the design principles, actuation methods, application prospect, limitations, and challenge. And we also provide perspective for the future development. We hope that with the development of material science, Engineering ethics, and manufacture technology, new methods can be applied to manufacture continuum robots for specific surgical procedures.

Scene text detection is attracting more and more attention and has become an important topic in machine vision research. With the development of mobile IoT (Internet of things) and deep learning technology, text detection research has made significant progress. This survey aims to summarize and analyze the main challenges and significant progress in scene text detection research. In this paper, we first introduce the history and progress of scene text detection and classify the traditional methods and deep learning-based methods in detail, pointing out the corresponding key issues and techniques. Then, we introduce commonly used benchmark datasets and evaluation protocols and identify state-of-the-art algorithms by comparison. Finally, we summarize and predict potential future research directions.

Ionizing radiation creates free radicals, the effect of which is enhanced by the presence of oxygen; a low oxygen level produces radioprotective effects for insects compared with irradiation in ambient air. Modified (controlled) atmosphere packaging is used for maintaining quality and shelf-life extension; therefore, treatment efficacy may be affected, and there is a need to determine the critical O2 levels that may cause radioprotective effects. Late third-instar Bactrocera dorsalis (Hendel) larvae were irradiated in bags filled with ambient or low-oxygen air (0%, 2%, 4%, 6%, 8% O2) and were exposed to radiation doses of 8 to 64 Gy with intervals of 8 Gy. Efficacy was measured by the prevention of adult emergence. Dose–response data on mortality (failure of adult emergence) were analyzed via two-way ANOVA (analysis of variance), ANCOVA (analysis of covariance), and probit regression. The difference in radiotolerance was only significant in 0% O2 atmospheres through two-way ANOVA; therefore, the 95% confidence limits (CLs) of lethal dose ratios at LD99 were used to determine significant differences between treatments at different O2 levels. The differences in radiotolerance were significant in 0% and 2% O2 but insignificant in 4%, 6%, and 8% O2 environments when compared with radiation in ambient air. The critical threshold of radioprotective effects for late third-instar B. dorsalis larvae is an O2 level of ≥4% and

Studies have demonstrated that the solute carrier family 11 member 1 (SLC11A1) is heavily glycosylated and phosphorylated in macrophages. However, the mechanisms of SLC11A1 phosphorylation, and the effects of phosphorylation on SLC11A1 activity remain largely unknown. Here, the tyrosine phosphorylation of SLC11A1 is observed in SLC11A1-expressing U937 cells when differentiated into macrophages by phorbol myristate acetate (PMA). The phosphorylation of SLC11A1 is almost completely blocked by treatment with PP2, a selective inhibitor of Src family kinases. Furthermore, we found that SLC11A1 is a direct substrate for active c-Src kinase and siRNA-mediated knockdown of cellular Src (c-Src) expression results in a significant decrease in tyrosine phosphorylation. We found that PMA induces the interaction of SLC11A1 with c-Src kinase. We demonstrated that SLC11A1 is phosphorylated by Src family kinases at tyrosine 15 and this type of phosphorylation is required for SLC11A1-mediated modulation of NF-κB activation and nitric oxide (NO) production induced by LPS. Our results demonstrate important roles for c-Src tyrosine kinase in phosphorylation and activation of SLC11A1 in macrophages.

Timber is used extensively in construction. Therefore, it is important to characterize the response of wood when exposed to elevated temperatures for a sustained period of time. In fire-resistant designs for timber structures, the main goal is to assess in-fire and post-fire structural integrity. The objectives of this study were to study the immediate effect and the residual effect of temperature on bending properties for Chinese larch (Larix gmelinii). A total of 72 specimens were subjected to a static 3-point bending test at various temperatures. The results indicated that both the bending strength (BS) and modulus of elasticity (MOE) decreased nonlinearly as the temperature was increased from 20 to 225 °C for the immediate effect test. For the residual effect test, both the BS and MOE first increased non-linearly and then decreased with increasing temperature. There were significant differences between the immediate effect test and the residual effect test for both BS and MOE. The bending properties in the residual effect test were larger than those in the immediate effect test.

The older and deeper hydrocarbon accumulations receive increasing attention across the world, providing more technical and commercial challenges to hydrocarbon exploration. We present a study of an asymmetrical, N-S striking intracratonic sag which developed across the Sichuan basin, south China, from Late Ediacaran to Early Cambrian times. The Mianyang-Changning intracratonic sag is ~50 km wide, with its steepest part in the basin center. In particular the eastern margin shows its greatest steepness. Five episodes in the evolutions of the sag can be recognized. It begins in the Late Ediacaran with an uplift and erosion correlated to Tongwan movement. Initial extension occurred during the Early Cambrian Maidiping period, when more strata of the Maidiping Formation were deposited across the sag. Subsequently, maximum extension occurred during the Early Cambrian Qiongzhusi period that resulted in 450–1700 m thick Maidiping-Canglangpu Formations being deposited in the sag. Then, the sag disappeared at the Longwangmiao period, as it was infilled by the sediments. The intracratonic sag has significant influence on the development of high-quality reservoirs in the Dengying and Longwangmiao Formations and source-rock of the Niutitang Formation. It thus indicates that a high probability for oil/gas accumulation exists along the intracratonic sag, across the central Sichuan basin.

The objective of this study was to determine the design value for the compressive strength (CS) for bamboo fiber-reinforced composite (BFRC) based on a reliability analysis. A total of 180 specimens were subjected to static compressive testing. The CS of the BFRC was significantly higher than that of raw bamboo and other bamboo-based composites, and its cumulative probability distribution accorded with a normal distribution. Furthermore, a calculation program of the reliability index (β) was developed by adopting the first-order second-moment method. Results of the reliability analysis indicate that β increases nonlinearly not only with the enhancement of the partial coefficient but also with the live-to-dead load ratio in all the simulation load cases. The simulation load case of the maximum and minimum β is G+LO and G+LS, respectively. To meet the target reliability requirement, it is suggested that the design value of CS for BFRC be 43.247 MPa and the partial coefficient be 2.0.

A safety analysis for Larch (Larix gmelinii) 2×4 lumber, based on the requirements of Chinese national standards, is presented in this paper. Static, third-point bending tests were conducted using an MTS universal testing machine. The bending strength was adjusted to 15% moisture content (MOR15) and was fitted with three different probability distribution models. The best fitting MOR15 model for Larch 2×4 lumber possessed lognormal distribution. Furthermore, a procedure for calculation of a reliability index (β) was developed using the first-order second-moment method. Results of reliability analysis indicated that the reliability index decreased nonlinearly as both the design value of bending strength increased and the reduction of live to dead load ratio (ρ). Finally, it was suggested that the design values for the bending strength of Larch 2×4 lumber were 18.4 MPa for grade SS, 11.6 MPa for grade No.1, 12.7 MPa for grade No.2, and 10.3 MPa for grade No.3, to meet the target reliability level.

Experiments were performed to test the compressive strength of bamboo scrimber board at different grain angle directions. Investigation of test samples allows for the identification of the correlation between compression failure stress and various failure mechanisms at different grain angles. The results of the experiments showed that the density of bamboo scrimber influenced compression failure stress linearly. A new approach to describe the failure stresses of bamboo scrimber was proposed. The density was introduced as a model parameter to describe compressive properties at varying angles of grain. In comparison to a one-dimensional model, there was much less relative error between predicted values and measured values by this 2D model. This report aims to improve the precision of existing strength models for various grain angles and to provide a competing method for the practical use of bamboo scrimber.

Chaohu basin is located in the central economic belt, as an important part of the Yangtze River Basin. Based on the data of land use classification from 2000 to 2015, this paper makes a dynamic econometric analysis on the spatial structure of land use in Chaohu basin. The results show that: (1) The agricultural land has been in a downward trend from 2000 to 2015. However, the construction land has been increasing. From 2005 to 2010, the change of agriculture and the construction land have reached the maximum value, which are -0.279% and 1.814%, respectively. (2) During 2000-2015, every five years, the change of land use degree in Chaohu basin is greater than 0. The land use in the study area is in the development period, among which the change of land use from 2000 to 2005 is the largest. (3) The information entropy of land use in Chaohu basin is more than 1, and the change of information entropy is more than 0, which indicates that the information entropy is on the rise and the land use is in disorder. The results are of practical significance to the ecological security and optimal regulation of Chaohu Basin.

Nanoparticles composed of galactosylated chitosan oligosaccharide (Gal-CSO) and adenosine triphosphate (ATP) were prepared for hepatocellular carcinoma cell-specific uptake, and the characteristics of Gal-CSO/ATP nanoparticles were evaluated. CSO/ATP nanoparticles were prepared as a control. The average diameter and zeta potential of Gal-CSO/ATP nanoparticles were 51.03 ± 3.26 nm and 30.50 ± 1.25 mV, respectively, suggesting suitable properties for a drug delivery system. Subsequently, the cytotoxicity of Gal-CSO/ATP nanoparticles were examined by the methyl tetrazolium (MTT) assay, and the half maximal inhibitory concentration (IC50) values were calculated with HepG2 (human hepatocellular carcinoma cell line) cells. The results showed that the cytotoxic effect of nanoparticles on HepG2 cells was low. In the meantime, it was also found that the Gal-CSO/ATP nanoparticles could be uptaken by HepG2 cells, due to expression of the asialoglycoprotein receptor (ASGP-R) on their surfaces. The presented results indicate that the Gal-CSO nanoparticles might be very attractive to be used as an intracellular drug delivery carrier for hepatocellular carcinoma cell targeting, thus warranting further in vivo or clinical investigations.

To investigate the prevalence of general and abdominal obesity and associated factors in Bouyei and Han peoples.A cross-sectional study was carried out in Guizhou province, southwest China in 2012, with multi-stage sampling to enroll 4551 participants aged 20 to 80 years. General and abdominal obesity were defined by World Health Organization (WHO) for Chinese. A design-based analysis was performed to evaluate prevalence of obesity and its related factors.Bouyei people had a significantly lower prevalence of general obesity (4.8% vs. 10.9%, p < 0.05) and abdominal obesity (13.6% vs. 26.8%, p < 0.05) than that in Han people. Prevalence of obesity increased with age until middle-age period and declined thereafter. Men aged 40-49 years group and women aged 50-59 years group have the highest prevalence of general obesity. Prevalence of abdominal obesity was higher than that of general obesity. Middle-age, Higher income, Han people were significantly associated with an increased risk of General/abdominal obesity.Bouyei people had a lower prevalence of general and abdominal obesity than the Han people. Etiological studies should be conducted to determine underlying genetic factors and dietary factors.

Atypical coronary artery disease (ACAD) is characterized by atypical angina pectoris or silent myocardial ischemia. However, conventional diagnostic techniques are insufficient to identify this subtype of coronary atherosclerotic pathology, and specific and sensitive markers for diagnosing ACAD are still currently lacking. The aim of the present study is to identify a novel serum microRNA (miRNA) expression profile of ACAD patients and evaluate its clinical diagnostic value.127 patients who were diagnosed with ACAD and 54 age-matched controls were enrolled in this study. An initial screen of miRNA expression was performed in serum samples from 35 patients and 20 controls using TaqMan Low Density Array. A stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay was conducted in the training and validation sets to confirm the levels of the altered miRNAs in 122 patients with ACAD and 68 controls. In addition, the potential target genes of the altered miRNAs were predicted using bioinformatics methods.The TaqMan low density array and RT-qPCR analysis identified four serum miRNAs including miR-487a, miR-502, miR-208 and miR-215 that were significantly increased, while one miRNA, miR-29b, that was significantly decreased in ACAD patients compared with normal controls (P

BACKGROUND: The exacerbation of IgA nephropathy (IgAN) is related to respiratory tract infection with hemolytic streptococcus (HS), but the mechanism is unknown. In this study we investigated the role of chemokine ligand 20 (CCL20) in response to the effect of T helper 17 (Th17) cells in the pathogenesis of IgAN associated with HS. METHODS: Thirty mice were randomly divided into five groups: control mice (control), IgAN mice (IgAN), HS-infected IgAN mice (HS-IgAN), CCL20-treated IgAN mice (CCL20-IgAN), and CCL20-treated HS infected IgAN mice (CCL20-HS-IgAN). IgAN mice were induced with lipopolysaccharide, carbon tetrachloride and bovine serum albumin. Then the mice were sensitized with CCL20 antibody and infected with alpha-hemolytic streptococcus (α-HS) isolated from tonsils in sequence. Urine Albumin-Creatinine ratio and sediments were measured. The pathological changes in kidney and lung tissues were observed under microscopy. Th17 cells and regulatory T cells (Tregs) in kidneys were tested by flow cytometry. CCL20, IL-17A, IL-6 and IL-21 in the kidneys were detected by ELISA. RESULTS: The IgAN mice had albuminuria and microscopic hematuria, renal mesangial proliferation, IgA deposition, high electron dense deposition in glomerular mesangial region, decreased frequency of Tregs, increased frequency of Th17 and Th17-Treg ratio. Furthermore, Th17-related cytokines CCL20, IL-17A, IL-6 and IL-21 were all increased in the kidneys of IgAN mice. Compared with IgAN mice, the manifestations in HS-IgAN mice were more severe, but alleviated in CCL20-treated groups. CONCLUSION: α-HS may exacerbate kidney damage in IgAN through CCL20 response to the effect of Th17 cells.

Integrated field data, microstructural and three-dimensional strain analyses are used to document coaxial N-S shortening and southward increase in deformation intensity and metamorphism at the Jiaochang structure. Two episodes of deformation (D1,D2) with localized post-D2 deformation have been identified in the area. The first deformation (D1) episode is defined by a main axial-plane of parallel folds observable on a micro- to kilometer-scale, while the second episode of deformation (D2) is defined by micro-scale metamorphic folds, associated with E-W oriented stretching lineation. These processes are the result of Indosinian tectonism (Late Triassic to Early Jurassic) characterized by nearly coaxial N-S compression and deformation. This is indicated by E-W trending, sub-parallel to parallel foliation (S1, e.g. axial-plane of folds, and S2, i.e. axial-plane of metamorphic folds, crenulation cleavage) and lineation (L1, e.g. axis of folds, and L2, i.e. stretching lineation, axis of metamorphic folds and B-axis of echelon lens). Most of the porphyroblasts and minerals (e.g. pyrite, biotite) show two growth phases with localized growth in the third phase (muscovite). The progressive D1-D2 structure is widespread in the south of the Jiaochang area, but only D1 structure crops out at the north. The strain intensity (γ), compression ratios (c%) and octahedral strain intensity (εs) are similar across the Jiaochang structure (i.e., γ ≈ 1.8, c ≈ 27%, εs = 0.9), showing a broad range of Flinn values (K = 0.77 to 7.57). The long-axis orientations are roughly symmetric between two limbs of the structure. Therefore, we suggest that the architecture of the Jiaochang structure has been controlled by coaxial N-S shortening and deformation (D1-D2) during the Indosinian tectonic epoch, with insignificant post-D2 deformation.

BACKGROUND: The association of diabetes mellitus (DM) with nonarteritic anterior ischemic optic neuropathy (NAION) has been inconclusive. PURPOSE: To determine whether DM is associated with an increased risk of NAION. METHODS: A comprehensive literature search was performed for published studies reporting both DM and NAION based on PubMed and EMBASE. After reviewing characteristics of all the included studies systematically, meta-analytical method was employed to calculate the pooled odds ratio (OR) and associated 95% confidence interval (CI) from random-effects models. Heterogeneity was assessed by Q-statistic test. Funnel Plot, Begg's and Egger's linear regression test were applied to evaluate publication bias. A sensitivity analysis and meta-regression analysis were also performed to assess the robustness of results. RESULTS: 2,096 participants from 12 case-control studies were pooled for a meta-analysis. The result of meta-analysis of these studies indicated that DM is associated with increased risk of NAION (pooled OR = 1.64, 95% CI = 1.17-2.30; P = 0.004). Sensitivity analysis indicated our findings are robust, and meta-regression analysis revealed no significant effect in terms of geographical area, gender, age of patients with NAION, the year of the publication, source of the controls, and sample size (all p>0.05). Evidence of publication bias was not observed in our study. CONCLUSION: Meta-analysis suggests that DM might be associated with increased risk of NAION.

The objective of this study was to investigate the compressive strength parallel to the grain of bamboo scrimber during and after exposure to various temperatures, in a range from 20 to 225 °C. These data were used to provide a basis for the evaluation of the fire performance of bamboo structures. A total of 152 specimens, assembled as group “during-fire” and “post-fire”, were tested during and after exposure to high temperatures. The experimental results indicated that there were significant differences in compressive properties between the “during-fire” and “post-fire” groups. At one temperature level, the compressive strength and modulus of elasticity of the “post-fire” group were significantly higher than those properties of the “during fire” group, but the ductility coefficient was reversed. FTIR analysis results showed that 175 °C was a key turning point, at which thermal decomposition occurred in the cellulose of the bamboo and phenolic resin.

This study investigated the size effect on the bending strength (modulus of rupture—MOR) of dimension lumber of Northeast China larch (Larix gmelinii); providing a basis for the further application in light wood frame construction. Experimental and statistical evaluations were conducted on the bending strength. A total of 2409 full-size dimension lumber samples were tested by static bending tests; which included three different sizes: 2 × 3; 2 × 4; and 2 × 6. Results indicate that the size has a significant effect on the MOR. Both the chi-square (χ2) and Kolmogorov-Smirnov (K-S) test results show that the lognormal distribution generally fits to the MOR better than to the normal distribution. Additionally; the effects of partial safety factor (γR) and live-to-dead load ratio (ρ) were studied by reliability analysis. Reliability analysis results indicate that the reliability index increases nonlinearly with the decrease of γR and the rise of ρ. Finally; the design value of bending strength and its adjusting factor of size effect of 2 × 3; 2 × 4; and 2 × 6 larch dimension lumber were obtained according to the Chinese National Standards’ requirements of the reliability index.