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Biomass-based pellet is an important source of renewable energy. In this study, to obtain the high-quality fuel pellet via the densification of pruned branches of fruit trees, we investigated the optimization of blending ratios for different raw materials using branches from jujube (Ziziphus jujuba Mill.), which is a widely distributed waste biomass resource in China. Through the characterization of raw materials and pellets, the effects of different raw materials on the storage, transportation, and combustion performances of the pellets can be understood. The cost evaluation analysis showed that the two optimized, co-densified pellets had great cost advantages compared with the pure jujube branch pellets. This indicates the potential industrial value of optimized pellets. The results of this study can help to improve the application value of orchard residues and generate an additional profit for fruit plantations, simultaneously avoiding the environmental damage caused by its open combustion.

Background Infertility, an important source of stress, could affect sexual life. Extensive studies suggest that the incidence of sexual dysfunction is highly prevalent in infertile women. As the duration of infertility increases, the level of stress is also likely to increase even further, and this could aggravate psychological pain and cause sexual dysfunction. However, the effect of infertility duration on sexual health is unclear. Methods We conducted a case-control study in which 715 patients participated between September 1,2020 and December 25, 2020. We included patients diagnosed with infertility (aged between 20 to 45), who were divided into four groups according to their infertility durations: ≤ 2 years (Group I, n = 262), > 2 years but ≤ 5 years (Group II, n = 282), > 5 years but ≤ 8 years (Group III, n = 97), and > 8 years (Group IV, n = 74). A questionnaire survey on female sexual functions and psychological depression was administered to participants, and their female sexual functions and depression status were measured using the Female Sexual Function Index (FSFI) and Patient Health Questionnaire (PHQ-9), respectively. Results As the number of years of infertility increased, the PHQ-9 score as well as the incidence of psychological depression increased significantly (p < 0.05), but the total score of FSFI and those of its six domains/sub-scales were not significantly different among the four groups. An analysis of the relevant factors affecting sexual functions, using the multivariable logistic regression model, revealed that when the infertility duration was greater than 8 years, there was a significant increase in the incidence of sexual dysfunction [adjusted odds ratios (AOR) = 5.158, 95% confidence interval (CI): 1.935–13.746, P = 0.001], arousal disorder (AOR = 2.955, 95% CI: 1.194–7.314, P = 0.019), coital pain (AOR = 3.811, 95% CI: 1.045–13.897, P = 0.043), and lubrication disorder (AOR = 5.077, 95% CI: 1.340–19.244, P = 0.017). Conclusions An increasing infertility duration is a risk factor for the occurrence of sexual dysfunction. Hence, as the infertility duration increases, the incidence of female sexual dysfunction and psychological distress could also increase, especially when the infertility duration is more than 8 years.

Vascular calcification is very commonly observed in patients with chronic kidney disease (CKD), but there is no efficient therapy available. Oxidative stress plays critical roles in the progression of vascular calcification. Celastrol (Cel), a natural constituent derived from Chinese herbals, exhibits anti-oxidative stress activity. Here, we investigated the effect of celastrol on vascular calcification using vascular smooth muscle cells (VSMCs), arterial rings and CKD rats. Alizarin red staining and gene expression analysis showed that Cel dose-dependently inhibited rat VSMC calcification and osteogenic differentiation. Similarly, ex vivo study revealed that Cel inhibited calcification of rat and human arterial rings. In addition, micro-computed tomography, alizarin red staining and calcium content analysis confirmed that Cel inhibited aortic calcification in CKD rats. Interestingly, Cel treatment increased the mRNA and protein levels of heme oxygenase-1 (HMOX-1), and reduced the levels of reactive oxygen species (ROS) in VSMCs. Furthermore, both pharmacological inhibition of HMOX-1 and knockdown of HMOX-1 by siRNA independently counteracted the inhibitory effect of Cel on vascular calcification. Moreover, knockdown of HMOX-1 prevented Cel treatment-mediated reduction in ROS levels. Finally, Cel treatment reduced Vitamin D3-induced aortic calcification in mice and this effect was blocked by HMOX-1 inhibitor ZnPP9. Collectively, our results suggest that up-regulation of HMOX-1 is required for the inhibitory effect of Cel on vascular calcification. Modulation of HMOX-1 may provide a novel strategy for the treatment of vascular calcification in CKD.

Vascular calcification is an actively regulated process resembling bone formation and contributes to the cardiovascular morbidity and mortality of chronic kidney disease (CKD). However, an effective therapy for vascular calcification is still lacking. The ketone body β-hydroxybutyrate (BHB) has been demonstrated to have health-promoting effects including anti-inflammation and cardiovascular protective effects. However, whether BHB protects against vascular calcification in CKD remains unclear. In this study, Alizarin Red staining and calcium content assay showed that BHB reduced calcification of vascular smooth muscle cells (VSMCs) and arterial rings. Of note, compared with CKD patients without thoracic calcification, serum BHB levels were lower in CKD patients with thoracic calcification. Supplementation with 1,3-butanediol (1,3-B), the precursor of BHB, attenuated aortic calcification in CKD rats and VitD3-overloaded mice. Furthermore, RNA-seq analysis revealed that BHB downregulated HDAC9, which was further confirmed by RT-qPCR and western blot analysis. Both pharmacological inhibition and knockdown of HDAC9 attenuated calcification of human VSMCs, while overexpression of HDAC9 exacerbated calcification of VSMCs and aortic rings, indicating that HDAC9 promotes vascular calcification under CKD conditions. Of note, BHB treatment antagonized HDAC9-induced vascular calcification. In addition, HDAC9 overexpression activated the NF-κB signaling pathway and inhibition of NF-κB attenuated HDAC9-induced VSMC calcification, suggesting that HDAC9 promotes vascular calcification via activation of NF-κB. In conclusion, our study demonstrates that BHB supplementation inhibits vascular calcification in CKD via modulation of the HDAC9-dependent NF-κB signaling pathway. Moreover, we unveil a crucial mechanistic role of HDAC9 in vascular calcification under CKD conditions; thus, nutritional intervention or pharmacological approaches to enhance BHB levels could act as promising therapeutic strategies to target HDAC9 for the treatment of vascular calcification in CKD. © 2022 The Pathological Society of Great Britain and Ireland.

Oaks (Quercus spp.) are considered as model plants for studying plant evolution and natural gene introgression. However, interspecific hybridization often occurred in sympatric sibling specie, resulting in blurred interspecific boundaries and hindering the development of breeding. Beijing area is at the junction between Taihang Mountain and Yanshan Mountain. It is a key area for deciduous oaks native to China and an overlapping area of several oaks. It is urgently necessary to evaluate the genetic diversity and population structure of the 4 deciduous oak species to understand the degree of gene introgression and to screen out ideal breeding materials. In this study, we collected 11 populations of 4 oak species (Q. variabilis, Q. mongolica, Q. dentata and Q. aliena) in the junction between Taihang Mountain and Yanshan Mountain. By using the polymorphic SSR markers, we analyzed the genetic variation of the collected 400 individuals and investigated the population structure and found gene introgression events. Q. variabilis had a clearer genetic background as compared to the other three species and the artificial population of Q. variabilis might have been transplanted from other regions outside Beijing. Q. mongolica had a more frequent gene introgression with Q. dentata and Q. aliena in this area. In addition, our results provided DNA fingerprints of the sampled 40 individuals according 9 SSR markers. This research reported useful SSR data for analyzing the genetic variation of oak species native to China, laying the foundation of whole genome sequencing and conducting an oak germplasm nursery with clear genetic background.

Due to melanoma is one of the skin cancers with the highest mortality rate and have a large amount of data during the collection and diagnosis, there is an urgent need to improve the diagnostic efficiency and accuracy. However, there remain problems in analyzing medical big data for skin lesion application, such as the intra-class variation and inter-class similarity in skin lesion images and the lacks of ability to focus on the lesion area affecting the classification results of the model. To address these dilemmas, in this paper, we proposed a novel machine learning-based approach that builds on top of DenseNet. It combines the attention mechanism and large margin loss to enhance the classification accuracy in terms of intra-class compactness and inter-class separability. We evaluated our model on ISIC 2017 (International Skin Imaging Collaboration) dataset, which has achieved 92% of Mean AUC. The experimental results show the effectiveness of our solution outperforms the state-of-the-art significantly in classify skin lesion and can accurately classify malignant melanoma on medical images.

Ceramics have been widely used in the field of tribology due to their superior corrosion resistance and low friction coefficient. The tribological properties of ceramics can be improved by machining proper surface texture. This work uses a nanosecond laser to process dimples on different ceramic surfaces. The morphology and size of dimples as a function of the number of laser shots and laser power are investigated. A theoretical model relating laser parameters and dimple size is established. In the initial point contact friction test, based on the experimental parameters mentioned in this paper, the existence of surface texture reduces the wear volume of Si3N4 balls in water by 41.5% and the wear volume of ZrO2 balls in oil by 51%.

Salvia miltiorrhiza is a traditional Chinese medicine with the application of more than a two-thousand-year history. It is a common medicine used in the clinical treatment of cardiovascular and cerebrovascular diseases and is listed as the top grade in Shennong's Classic of Materia Medica. Polysaccharide is an important chemical component of Salvia miltiorrhiza and has a variety of biological activities.In this review, we summarized the preparation methods, structural characteristics, and biological activities of Salvia miltiorrhiza polysaccharides, as well as discussed current research problems, providing support for further research, development, and utilization.By inputting the search term "Salvia miltiorrhiza polysaccharides", relevant research information was obtained from databases such as Google Scholar, PubMed, VIP, Web of Science, and China Knowledge Network (CNKI).It has been found that the monosaccharide composition of Salvia miltiorrhiza polysaccharides containing glucose (Glc), galactose (Gal), mannose (Man), and arabinose (Ara) has antioxidant, anti-tumor, liver protection, and other activities.We summarized the preparation methods, structural information, and biological activities of Salvia miltiorrhiza polysaccharides in this review and discussed the issues that are currently being researched. Although this product has a wide range of biological activities and has high development and utilization potential, its structure information and structure-activity relationship require further investigation.

Multitask joint learning technology continues gaining more attention as a paradigm shift and has shown promising performance in many applications. Depth estimation and semantic understanding from monocular images emerge as a challenging problem in computer vision. While the other joint learning frameworks establish the relationship between the semantics and depth from stereo pairs, the lack of learning camera motion renders the frameworks that fail to model the geometric structure of the image scene. We make a further step in this article by proposing a multitask learning method, namely DPSNet, which can jointly perform depth and camera pose estimation and semantic scene segmentation. Our core idea for depth and camera pose prediction is that we present the rigid semantic consistency loss to overcome the limitation of moving pixels from image reconstruction technology and further infer the segmentation of moving instances based on them. In addition, our proposed model performs semantic segmentation by reasoning the geometric correspondences between the pixel semantic outputs and the semantic labels at multiscale resolutions. Experiments on open-source datasets and a video dataset captured on a micro-smart car show the effectiveness of each component of DPSNet, and DPSNet achieves state-of-the-art results in all three tasks compared with the best popular methods. All our models and code are available at https://github.com/jn-z/DPSNet: Multitask Learning Using Geometry Reasoning for Scene Depth and semantics.

Li-rich layered cathodes based on Li2MnO3 have exhibited extraordinary promise to satisfy the rapidly increasing demand for high-energy density Li-ion batteries. However, besides cationic redox, oxygen anionic redox contributing to extra charge transfer often suffers from local structural transformation through O–O bond formation, leading to partial irreversibility during discharge. Four typical transition metal (TM) substitution models Li2Mn0.75TM0.25O3 (TM = Nb, Mo, Ru and Rh) are selected to calculate reversible capacity and perform electronic structure analysis. Our calculations reveal that the inherent t2g orbital of TMs around the Fermi level plays a key role in stabilizing the anionic lattice and operating cationic redox, which further favors anionic redox reversibility. An electron occupancy number Nt2g = 4 of the t2g orbital in substitutional TM cations is identified as the optimal value to achieve a maximum reversible capacity from cationic and anionic redox. Experimentally, Li2Mn0.75Ru0.25O3 exhibits improved reversible capacity by 18.1% at 0.1C compared to Li2MnO3, confirming the suppression effect of Ru on the oxidation of lattice oxygen. The present study provides a new insight into developing high-capacity layered electrodes with good reversibility.

Methane catalytic abilities are considered to be an important and direct form of experimental evidence for evaluating the efficacy of mixed oxide-ion/electron conductors (MIEC) as anode materials for solid oxide fuel cells (SOFCs) with CH4 as the fuel gas. Therefore, a direct link between the quantifiable methane-conversion abilities and CH4-based SOFC electrochemical performance is urgently needed. Here, H2-reduced Sr2ZnMoO6 (R-SZMO) as an anode example exhibits excellent catalytic abilities and tolerance to coking when using CH4 as the fuel gas, which is dominated by the formation of intrinsic anion-Frenkel defect pairs. DFT calculations reveal that the efficient electron transfer process and optimal selectivity towards CH4 conversion are both on the R-SZMO (110) surface. Therefore, applying high CH4 activity R-SZMO as the anode catalyst gives excellent anti-carbon deposition performance, high power output, and long-term stability for SOFCs with CH4 as the fuel gas.

Anionic oxygen redox chemistry in Li-excess transition metal oxides has emerged as a new paradigm to increase the energy density of rechargeable batteries. However, the anionic redox of oxygen mostly forms the O–O bond, leading to partly irreversible discharge. To address this issue, we demonstrate a new strategy to achieve dual functions of activating cation activity and enhancing oxygen anion redox activity in Li2MnO3 through a light metal (Mg, Ca and Al) substitution of Li. Our first-principle thermodynamic calculations show that Mg2+ substitution in Li2MnO3 prefers locating at the Li+ site, which induces the formation of reductive Mn-ions with electrochemical activity. The substituted local structure of (Li–O–Mg)/2(Li–O–Mn) becomes more electrochemically stable than the specific Li–O–Li local structure in Li2MnO3, which effectively retards O–O combination. Therefore, the reversible capacity (245 mA h g−1) of the optimal substituent compound Li1.5Mg0.5MnO3 is significantly improved compared with that (115 mA h g−1) of Li2MnO3. More importantly, this substitution strategy can be effectively extended to other Li-rich electrodes such as Li3VO4 and Li3NbO4 with Mg-substitution activating cationic redox. The study opens a new avenue in improving the reversible capacity of Li-rich cathode materials through low-cost element substitution.

There is currently great interest in aqueous rechargeable Zn/MnO2 batteries due to their advantages of low cost, high specific energy density, and environmental friendliness. However, the poor conductivity and low utilization of the MnO2 cathode during the electrochemical reaction are the bottlenecks to achieving high power density and acceptable reversibility. Unlike most studies on the modification of MnO2 cathodes, this work proposes a new bromide–acetate co-mediated multicomponent metal-ion aqueous electrolyte to realize a highly reversible and high-specific capacity two-electron transfer reaction between Mn2+ and MnO2. In particular, extremely fast reaction kinetics is achieved due to the bromide modifier additive, which can incorporate into the solvation shells of the Zn2+ and Mn2+ aquo-complex and weaken their solvation effect. Therefore, not only are ultrahigh-rate performance (32C) and power density of 1770 W kg−1 (based on MnO2) realized, but also a long cycling stability of 2500 cycles (10C) is demonstrated. Raman spectroscopy, FTIR spectroscopy, and DFT calculation further reveal the co-mediation mechanism of bromide and acetate in the fast and reversible transformation between Mn2+ and MnO2. This work accentuates the importance of the electrolyte in aqueous batteries and the great potential of high-performance Zn–MnO2 batteries with low-cost bromide and acetate-based electrolyte for large-scale energy storage.

The disordered Li-rich oxyfluoride cathodes not only offer potentials for high energy density through cooperative cationic and anionic redox but also for facile lithium diffusion by formatting activated percolating channels. Generally, the d0 transition metals (TM) are considered as an essential facilitator for stabilization of the cation-disordered phase, but no redox activity. Nevertheless, their influence on reversible cationic and anionic redox is not fully understood, and consequently preventing further material design. Here, our studies for typical material Li2Mn1/2Ti1/2O2F unequivocally demonstrate that the local configurations containing redox-inactive d0 TM make more contribution to reversible capacity than those containing electrochemically active Mn2+. The peculiar effect is attributed to forming low-energy charge-ordering state that d0 TM prefers staying with Li–O–Li and pushes down O 2p unbonding state into a low-energy level. The present study reveals that a disordered oxyfluoride cathode design achieving a high reversible capacity may necessarily consider a suitable ratio of active low-charge TM to high-charge d0 TM.

Data for face analysis often exhibit highly-skewed class distribution, i.e., most data belong to a few majority classes, while the minority classes only contain a scarce amount of instances. To mitigate this issue, contemporary deep learning methods typically follow classic strategies such as class re-sampling or cost-sensitive training. In this paper, we conduct extensive and systematic experiments to validate the effectiveness of these classic schemes for representation learning on class-imbalanced data. We further demonstrate that more discriminative deep representation can be learned by enforcing a deep network to maintain inter-cluster margins both within and between classes. This tight constraint effectively reduces the class imbalance inherent in the local data neighborhood, thus carving much more balanced class boundaries locally. We show that it is easy to deploy angular margins between the cluster distributions on a hypersphere manifold. Such learned Cluster-based Large Margin Local Embedding (CLMLE), when combined with a simple k-nearest cluster algorithm, shows significant improvements in accuracy over existing methods on both face recognition and face attribute prediction tasks that exhibit imbalanced class distribution., Comment: 14 pages, 10 figures, 8 tables. Accepted to TPAMI

A colorimetric and fluorometric dual probe based on a water-soluble polythiophene derivative (PMTPBA) was designed and synthesized. It can be applied to determination of picric acid (PA) in 100% aqueous solution. The approach relies on the formation of supramolecular polythiophene assemblies in the presence of PA through electrostatic, charge transfer and π-π stacking interactions. This probe could be utilized for the rapid and visual detection of PA both in aqueous solution and solid support with high specificity and sensitivity. The detection limit of this sensor is as low as 5.0 × 10-8 mol/L.

Objective To explore the survival value of cytoreductive partial nephrectomy (cPN) in elderly with metastatic renal cell carcinoma (EmRCC) and evaluate the characteristics of patients who benefit from cPN. Materials and methods This was a study including 6105 patients aged ≥65 years with metastatic renal cell carcinoma (RCC) queried from Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2015, among which 1264 patients underwent cytoreductive nephrectomy (CN), 78 patients underwent cPN and 1186 patients underwent cytoreductive radical nephrectomy (cRN). Kaplan-Meier (K-M) method and Cox proportional-hazards model (COX) were used to evaluate the survival prognosis. Overall survival (OS) was compared between groups using propensity score matching (PSM) to balance the effects of confounding factors such as general features and pathological features. At last, we constructed a nomogram visualization modelled by R language to predict survival. Results For patients with EmRCC, especially for male patients with tumors size ≤7 cm, N0 stage, or isolated metastases, cPN brought a better survival than cRN. Tumor size and N stage were independent risk factors affecting the survival of cPN patients. cPN for patients with tumor size >7 cm or N1 stage may present a higher risk of death. Conclusion The implementation of cPN for patients with EmRCC who meet specific clinical characteristics such as tumors size ≤7 cm, N0 stage, or isolated metastases seems to help improve the survival prognosis.

The aim of this study was to investigate the mechanism by which growth arrest‐specific transcript 5 (GAS5) regulates bladder cancer cells. Bladder cancer samples were collected and tested for experiment. Dual‐luciferase reporter assay was used to verify the downstream target genes for GAS5 and miR‐21. The expression level of GAS5 was decreased and that of miR‐21 was increased, indicating a negative correlation between the two. Patients with high GAS5 level and low miR‐21 level had relatively longer survival rates. GAS5 inhibited bladder cancer cells proliferation and promoted apoptosis, and miR‐21 had the opposite effects. MiR‐21 was a direct target for GAS5, whereas phosphatase and tensin homolog (PTEN) was a direct target gene of miR‐21. Low expression of miR‐21 could reverse the proliferative and antiapoptotic effects caused by GAS5 silencing. High levels of GAS5 and low levels of miR‐21 might be associated with a higher survival rate in bladder cancer patients. GAS5 could exert antiproliferative and proapoptotic effects on bladder cancer cells through miR‐21 and PTEN., In bladder cancer, the expression level of growth arrest‐specific transcript 5 (GAS5) was decreased and the expression level of miR‐21 was elevated, and high levels of GAS5 and low levels of miR‐21 might be associated with higher survival. MiR‐21 was a target of GAS5, and PTEN was a target gene of miR‐21. GAS5 could inhibit the proliferation of bladder cancer cells and promote apoptosis by regulating PTEN through miR‐21.

The incorporation of point defects such as cationic vacancies into electrode materials has been considered as an effective strategy to improve the charge-transfer and ion-diffusion kinetics and allow insertion and migration of multivalent ions. However, they suffer from low specific capacity and electrochemical irreversibility. To elucidate the origin of these issues, we investigated the F-doped and cation-deficient anatase TiO2 through Mg2+ insertion for understanding the redox activity of vacancy structure. Our first-principles calculations showed that charge transfer inductively occurs from anion O2−/F− to cation Ti4+ near vacancies, forming oxidized anions F(1−x)−/O(2−y)− and reduced cations Ti(4−z)+. We further found that cooperative cationic and anionic redox reactions, Ti3.83+ + 0.19e− → Ti3.64+, O1.94− + 0.06e− → O2− and F0.93− + 0.07e− → F−, take place during Mg2+ insertion. The peculiar anionic redox reaction of oxidized F 2p states is attributed to low-coordination fluorine ions, which was demonstrated by the previous NMR characterization. Our calculations showed that the fluorine redox reaction contributes 26.5% of the total redox capacity. The present results provided chemical clues to use the vacancy structure design to develop efficient cationic and anionic redox materials for improving the energy density and cyclic stability of battery materials.

Despite much progress achieved in the past decades in the process of advancing the low-temperature sintering technologies for Solid oxide fuel cells (SOFCs), such as via the structure design of the electrode materials, the practical application of low-temperature sintered SOFCs (with disqualified mechanical strength) remains challenging. In this work, first, we demonstrate that the appropriate amount of CuO as sintering aids can successfully reduce the co-firing temperature of conventional micron size NiO-YSZ (yttrium-stabilized zirconia (Y2O3)0.08–(ZrO2)0.92) anode from about 1400 °C to only 1100 °C. Second, the quantitative structure-activity relationship among the mechanical strength (low-temperature sintering ability) of anode cermets with the inclusion of CuO contents and the densification of YSZ electrolyte was synthetically evaluated, and the optimal Cu–NiO-YSZ anode composition demonstrates almost the equal mechanical strength when compared with the traditional NiO-YSZ anode (sintering at 1400 °C). At last, by comprehensive assessment, 8%Cu–52NiO-40YSZ (8%CuO–NiO-YSZ) shows excellent low-temperature sintering ability, high mechanical strength, optimal power output, and anti-carbon deposition when using as hydrocarbon-based anode for SOFCs.

Charge localization coupled Na-ion migration is the origin of multiple voltage plateaus in P2-type ordered layered NaxTMO2, whereas isolated active sites with different activities in the disordered compound can effectively avoid this phenomenon.

Description, Discovery of a novel pituitary protein suggests a new means to enhance fertility., Follicle-stimulating hormone (FSH), a key regulator of ovarian function, is often used in infertility treatment. Gonadal inhibins suppress FSH synthesis by pituitary gonadotrope cells. The TGFβ type III receptor, betaglycan, is required for inhibin A suppression of FSH. The inhibin B co-receptor was previously unknown. Here, we report that the gonadotrope-restricted transmembrane protein, TGFBR3L, is the elusive inhibin B co-receptor. TGFBR3L binds inhibin B but not other TGFβ family ligands. TGFBR3L knockdown or overexpression abrogates or confers inhibin B activity in cells. Female Tgfbr3l knockout mice exhibit increased FSH levels, ovarian follicle development, and litter sizes. In contrast, female mice lacking both TGFBR3L and betaglycan are infertile. TGFBR3L’s function and cell-specific expression make it an attractive new target for the regulation of FSH and fertility.

Metal–organic electrode materials have exhibited extraordinary promise for green and sustainable electrochemical energy storage devices, but usually suffer from low specific capacity, and poor cycling stability and rate capability because of limited active sites at organic functional groups. To address this issue, activating transition metals and carbon conjugate rings has become significantly effective to make transferred electrons dispersed in the whole molecule. In this work, we demonstrate that assembling inorganic–organic building blocks into “local” composite metal–organic materials could synergistically activate transition metal ions and carbon conjugate rings to operate cationic and anionic redox, respectively. Based on first-principles calculations, the composite inorganic–organic material FeF3(4,4′-bpy) generates 8-electron transfer redox processes of Fe3+ + 2e− → Fe+ and 2 –CN– + 2e− → 2 (–C–N–)− and 4 –CC– + 4e− → 4 (–C–C–)−, achieving a high specific capacity of 796.7 mA h g−1, maintaining structural stability, and reducing the band gap. The strongly electronegative F-ions in inorganic structure [FeF4]2− play an important role in making highly oxidized Fe3+ through forming a strong ligand field and electrochemically activating –CC– via electrostatic interaction with Li+. In addition, electrochemical measurements also reveal that the central metal Fe, and –CC and –CN bonds of the FeF3(4,4′-bpy) electrode are the active sites for Li-ion storage to deliver a high reversible capacity (793.1 mA h g−1 at 50 mA g−1) and excellent rate capability, which are echoes of the DFT calculations. Through this design principle, we found a series of high-capacity metal organic electrode materials such as MnF3(4,4′-bpy) (799.6 mA h g−1) and VF3(4,4′-bpy) (811.7 mA h g−1).

Background Antibodies to PD-1 and PD-L1 have remarkably improved the overall survival of many patients with advanced solid tumors. SHR-1210 is an anti-PD-1 monoclonal antibody. Dermatologic reactive capillary hemangiomas (RCH) were the most common and unique drug-related AEs of SHR-1210, but rare on oral mucosa and gastrointestinal mucosa. Herein we report a case of RCH occurred in oral mucosa during the clinical trials of SHR-1210 in the treatment of non-small cell lung cancer. Case presentation A male in his 60 s with a history of non-small cell lung cancer received injection of anti-PD-1 monoclonal antibodies SHR-1210. The patient developed drug-related RCH on skin after the first injection and began to have gingival hyperplasia one year after the first injection which gradually increased in size and affect eating and speaking. Anti-PD-1 treatments were continued. After periodontal treatment, two oral lesions and one skin lesion were surgically removed. Similar histological manifestation was found in all three lesions as reactive capillary hemangiomas. All lesions had a good prognosis without recurrence on oral mucosa within one year after surgery. Conclusions Oral reactive capillary hemangiomas could be induced by SHR-1210 in the treatment of non-small cell lung cancer. Surgical resection is an effective treatment with a good prognosis.

Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD). Cell death such as apoptosis plays a critical role in vascular calcification. Ferroptosis is a type of iron-catalyzed and regulated cell death resulting from excessive iron-dependent reactive oxygen species and lipid peroxidation. However, it is unclear whether ferroptosis of vascular smooth muscle cells (VSMCs) regulates vascular calcification in CKD. Our results showed that high calcium and phosphate concentrations induced ferroptosis in rat VSMCs in vitro. Inhibition of ferroptosis by ferrostatin-1 dose-dependently reduced mineral deposition in rat VSMCs under pro-osteogenic conditions, as indicated by alizarin red staining and quantification of calcium content. In addition, gene expression analysis revealed that ferrostatin-1 inhibited osteogenic differentiation of rat VSMCs. Similarly, ferrostatin-1 remarkably attenuated calcification of rat and human arterial rings ex vivo and aortic calcification in vitamin D

A multi-mode transceiver is presented to support 802.11b/g/n/ax, Bluetooth classic (BT) and low energy (BLE). The design features two signal paths and one merged RF port, demonstrating the first combo chip optimized for low power IoT applications. The highly efficient combo radio achieves comparable or better performance against standalone solutions. The receiver chain noise figure (NF) is measured at 2.7dB in 802.11ax mode, and the power consumption is 32mW, the lowest reported in literature. In BLE receiving mode, NF is 5dB while consuming 9.7mW. The measured 802.11 mask compliant output power is 21.5dBm with 22%/20% PA/Tx efficiency. With 1024-QAM OFDM (MCS11) signals, -35dB EVM can be achieved at 16dBm output power without digital pre-distortion (DPD). EVM floor reaches -42dB with 11n MCS7 signals. As for BLE transmission, 10.5dBm power can be delivered with 28%/21% PA/Tx efficiency. Implemented in 22nm CMOS technology, the entire radio occupies 2.1mm2 silicon area.

A water-soluble perylene imide derivative (PDI-Glu) was synthesized and their supramolecular aggregates composed of PDI-Glu and Al3+ were prepared as a “turn on” fluorometric probe to monitor F− in a purely aqueous system. Based on an “indicator displacement assay” (IDA) approach, the sensing performance and mechanism of PDI-Glu/Al3+ complex toward F− were investigated by absorption and emission spectra. It was suggested that disassembly of PDI-Glu/Al3+ aggregates was promoted by addition of F− through the competitive binding between Al3+ and F−. The detection limit is 240 nmol/L. This method featured simple preparation, excellent water solubility, adjustable self-assembly performance, ease of observation and operation, and high selectivity and sensitivity. It was used for monitoring F− in toothpaste and tap water samples with excellent accuracy and recovery. To the best of our knowledge, this is the first water-soluble perylene diimide-based probe for F− detection in 100% aqueous media. We believe this work could not only extend the sensing scope of water-soluble perylene diimide, but also bring some useful information for the rapid detection of anionic analytes in aqueous media.