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101. Acknowledgement to the Reviewers

Author

Yasuro Kumeda, Nora Klenk, Itsuro Kazama, Shin Suda, Ryuichiro Konda, Soon Bae Kim, Satish M. Rao, Iván Palomo, Toru Shinzato, Ken Farrington, Masayuki Iwano, Yukihiko Kawasaki, A. Sturiale, Ronald J. Falk, Yoshiyuki Tomiyoshi, Gilbert Deray, U. Eismann, Masaaki Inaba, Silvia Pierangeli, Marcela Vasquez, L. Garcia Garcia, Yasuhide Nakashima, Hitoshi Suzuki, Aquiles Jara, Júlia Széll, G. Di Pasquale, Takeshi Suda, Jaime Pereira, Lin Shan, Deniz Ayli, M. Buemi, Yee-Yung Ng, Masahito Tamura, Akane Kurisu, Satoru Kawaguchi, Takanobu Sakemi, Hidehiro Kakizaki, Masao Kanauchi, Y. Oyama, J. Vila Cots, A. Favaloro, Ulf Janssen, Kosei Segawa, Yoshiyuki Matsuo, Mükerrem Safali, Susumu Makino, Massimino Senatore, Tülin Gümüş, Yi-Hong Chou, Yong Soo Kim, G. Stein, J.A. Camacho Diaz, Magdolna Aleksza, A. Romeo, Masako Iwamoto, Ruriko Nozawa, Akihiko Osajima, Y. Asano, Keiji Fujiwara, G. Cutroneo, T. Rengarajan, Patrizia Colombo, Su-Kil Park, Hiroshi Shiraga, Oliviero Filiberti, Eri Muso, Koichiro Homma, Jürgen Floege, Sigeyuki Takeda, Takahiko Ono, Arnold J. Felsenfeld, Takayuki Ota, A. Vila Santandreu, N. Frisina, Wei-Ming Hsu, Magali Ciroldi, Choung Soo Kim, Bertalan Fodor, Mari Michimata, Lee-Moi Thien, Nai-Phon Wang, Masahiro Okazaki, Yuri Ozawa, Petra Marchand, J. Charles Jennette, Motoshi Hattori, Xixin Wu, Chin-Huang Chen, Izzet Yavuz, Pasqualina Cecere, A. Ruello, Omac Tufekcioglu, Heinfried H. Radeke, Cheri V. Barrett, Kyoko Kitauchi, Jin Kim, Zeki Odabaşi, Yoko Fujino, Hitoshi Goto, Huaji Chen, Hideo Nakai, M. Imai, An S. De Vriese, Hirofumi Matuoka, Seung Hun Lee, Ning Liu, Attila Nagy, Yoshiki Nishizawa, Carla Peona, Akira Owada, Aranka Koós, Katsumi Ito, Tadao Oohara, Shozo Hosokawa, M. Suzuki, Bum Soon Choi, Aled O. Phillips, Yasuhiro Komatsu, Kayser Caglar, M. Sommer, Sun Woo Lim, Michele Buemi, Tsung-Hsiu Wang, Giovanna Piccini, Toshihiko Hata, Luigia Costantini, Tomoko Nakamura, Y. Watanabe, Wu-Chang Yang, Katsuya Nonomura, Masuhisa Nakamura, Narutoshi Kabashima, Kenji Maeda, J. Gerth, Toshihiko Miwa, Sang Koo Lee, Eveline Sowa, Masamiki Miwa, G. Anastasi, Mitsunobu Matsubara, Takao Saruta, A. Concheiro Guisan, Seval Izdes, Susan L. Hogan, Shigehisa Aoki, Antonio Nicoletti, Lesley C Dinwiddie, Fuad S. Shihab, Paik-Seong Lim, Eiji Kusano, Gisho Honda, Takahiko Nagahama, Yuujiro Watanabe, Yutaka Imai, Enikő Sárváry, Yasushi Asano, Eiji Ishimura, Yoshihiko Saito, Mayumi Nagata, Takeshi Kanda, Toshio Hashimoto, F. Floccari, Qiu Mingcai, Naoko Matsumoto, Michiko Suzuki, C. Aloisi, Wan Young Kim, Chui-Mei Tiu, Cecilia Chacón, David A. Alcorta, Jung Sik Park, Hassane Izzedine, Mária Takács, Tsen-Tsai Chen, Byung Kee Bang, Koichi Hayashi, Junzo Suzuki, Motoaki Miyazono, A. Gimenez Llort, Giuseppe Rizzuto, Kaori Kanegae, Yasuo Imanishi, Norio Kurumatani, Toshiaki Makino, Chang-Linct Yang, Yutaro Hayashi, Jung Ho Cha, Song Lin, Chul Woo Yang, Won Seok Yang, Marcelo Alarcón, Müjdat Yenicesu, Tsutomu Araki, Gloria A. Preston, O. Iimura, Jorge Isaac, Toshikatsu Shimizu, C. Ito, Can Li, Hirofumi Anai, Tatsuya Nakatani, Shigeo Suzuki, Gabriella Lakos, Cüneyt Ensari, Shoji Nogae, Ottó Árkossy, Vincent Launay-Vacher, R. Ravichandran, K. Tamba, E. Kusano, Shigeru Nakai, Sacit Turanli, Chun-Cheng Hou, Ju Young Jung, Chiew H. Kong, Erzsébet Ladányi, Hyung Wook Kim, Yasuhiro Akai, F. Corica, Koji Harada, Sumiko Homma, Laurence Fardet, Sadayoshi Ito, Abdülgaffar Vural, and Sándor Sipka

Subjects
Medical education, business.industry, Acknowledgement, Medicine, business
Published
1998

103. A case of squamous cell carcinoma in hCG producing lung

Author

S Fujimoto, Hyoe Ishikawa, I Kinokawa, Toshio Hashimoto, Yasuhiro Akai, K Doi, and Y Sakaguchi

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, Lung squamous cell carcinoma, medicine, Carcinoma, MEDLINE, Combined Modality Therapy, General Medicine, medicine.disease, business, Hormone
Published
1994

104. Editorial / Publisher’s Note

Author

Marcela Vasquez, G. Di Pasquale, Takeshi Suda, Mükerrem Safali, Akihiko Osajima, Petra Marchand, Itsuro Kazama, Sacit Turanli, Hirofumi Matuoka, Chang-Linct Yang, Luigia Costantini, F. Floccari, Tadao Oohara, Shozo Hosokawa, Chiew H. Kong, Yutaro Hayashi, Heinfried H. Radeke, An S. De Vriese, J. Gerth, G. Anastasi, Takahiko Ono, Shigehisa Aoki, Satoru Kawaguchi, Takanobu Sakemi, Sumiko Homma, Sadayoshi Ito, Toshihiko Hata, Katsumi Ito, Mária Takács, Kenji Maeda, Takahiko Nagahama, Kyoko Kitauchi, O. Iimura, Arnold J. Felsenfeld, Jorge Isaac, Masayuki Iwano, Yasuhide Nakashima, Bum Soon Choi, Hidehiro Kakizaki, Masao Kanauchi, Yoshihiko Saito, Masako Iwamoto, G. Cutroneo, Y. Oyama, Qiu Mingcai, Ken Farrington, Toshikatsu Shimizu, Cheri V. Barrett, Fuad S. Shihab, A. Concheiro Guisan, M. Imai, Abdülgaffar Vural, Antonio Nicoletti, Seval Izdes, Masahito Tamura, K. Tamba, Massimino Senatore, Masaaki Inaba, Erzsébet Ladányi, Lesley C Dinwiddie, Yong Soo Kim, Tülin Gümüş, E. Kusano, Toshio Hashimoto, Hyung Wook Kim, Eiji Ishimura, Shin Suda, Tatsuya Nakatani, Yi-Hong Chou, Susan L. Hogan, Jung Ho Cha, Ruriko Nozawa, Marcelo Alarcón, J.A. Camacho Diaz, Magdolna Aleksza, A. Favaloro, Yutaka Imai, Yasuhiro Akai, F. Corica, Yuujiro Watanabe, Chun-Cheng Hou, Shigeo Suzuki, Aquiles Jara, Gabriella Lakos, N. Frisina, Júlia Széll, Ju Young Jung, Wei-Ming Hsu, C. Aloisi, Keiji Fujiwara, Motoshi Hattori, Akane Kurisu, Tsutomu Araki, Yoshiyuki Tomiyoshi, Gilbert Deray, Wan Young Kim, Carla Peona, Akira Owada, Aranka Koós, Magali Ciroldi, Ronald J. Falk, Chul Woo Yang, Chui-Mei Tiu, Kayser Caglar, Koji Harada, Jaime Pereira, Song Lin, Tsung-Hsiu Wang, Katsuya Nonomura, Mari Michimata, Yasushi Asano, Masamiki Miwa, Giuseppe Rizzuto, Naoko Matsumoto, Norio Kurumatani, Seung Hun Lee, Ning Liu, Kaori Kanegae, Jin Kim, Yasuro Kumeda, Huaji Chen, Yasuo Imanishi, Jung Sik Park, Nora Klenk, M. Sommer, A O Phillips, Sang Koo Lee, J. Charles Jennette, Hideo Nakai, Hirofumi Anai, Michele Buemi, Cüneyt Ensari, Attila Nagy, Yoshiki Nishizawa, Toshiaki Makino, Shoji Nogae, Won Seok Yang, Mitsunobu Matsubara, Takao Saruta, Narutoshi Kabashima, Eiji Kusano, Yasuhiro Komatsu, Shigeru Nakai, Ottó Árkossy, Sun Woo Lim, Ryuichiro Konda, Chin-Huang Chen, Soon Bae Kim, Hitoshi Goto, Yukihiko Kawasaki, Takeshi Kanda, Cecilia Chacón, L. Garcia Garcia, J. Vila Cots, Kosei Segawa, T. Rengarajan, Patrizia Colombo, Vincent Launay-Vacher, Yoshiyuki Matsuo, R. Ravichandran, Hitoshi Suzuki, C. Ito, Tomoko Nakamura, Can Li, Y. Watanabe, Wu-Chang Yang, Hassane Izzedine, Tsen-Tsai Chen, Zeki Odabaşi, Yoko Fujino, Eri Muso, Koichiro Homma, M. Suzuki, Jürgen Floege, Paik-Seong Lim, Gisho Honda, Susumu Makino, Xixin Wu, Müjdat Yenicesu, Eveline Sowa, A. Sturiale, Giovanna Piccini, Y. Asano, Gloria A. Preston, A. Romeo, Su-Kil Park, Izzet Yavuz, Masuhisa Nakamura, Mayumi Nagata, Motoaki Miyazono, A. Gimenez Llort, Laurence Fardet, Choung Soo Kim, Bertalan Fodor, David A. Alcorta, Junzo Suzuki, Toshihiko Miwa, Lee-Moi Thien, Nai-Phon Wang, Masahiro Okazaki, Yuri Ozawa, Koichi Hayashi, Enikő Sárváry, A. Ruello, Byung Kee Bang, Sándor Sipka, Satish M. Rao, Iván Palomo, Silvia Pierangeli, Toru Shinzato, U. Eismann, Michiko Suzuki, Hiroshi Shiraga, Oliviero Filiberti, Sigeyuki Takeda, Ulf Janssen, Pasqualina Cecere, Takayuki Ota, Lin Shan, Deniz Ayli, M. Buemi, Yee-Yung Ng, A. Vila Santandreu, G. Stein, and Omac Tufekcioglu

Subjects
business.industry, Medicine, business, Classics
Published
2002

105. Association of the missense Glu298Asp variant of eNOS gene with left ventricular hypertrophy and carotid atherosclerosis in patients with essential hypertension

Author

Yasuhiro Akai, Masayuki Iwano, Kazuhiro Dohi, Minoru Takaoka, and Shigeru Yamano

Subjects
Carotid atherosclerosis, Enos gene, medicine.medical_specialty, Essential hypertension, Left ventricular hypertrophy, Nitric oxide, chemistry.chemical_compound, medicine.artery, Internal medicine, Internal Medicine, medicine, Missense mutation, In patient, Common carotid artery, biology, business.industry, General Medicine, medicine.disease, Nitric oxide synthase, Blood pressure, Endocrinology, chemistry, Intima-media thickness, biology.protein, Cardiology, Cardiology and Cardiovascular Medicine, business
Published
2001

106. Association of TGF-b1 gene polymorphism with the progression of diabetic nephropathy and retinopathy

Author

Yasuhiro Akai, Hiroki Ozaki, Masao Kanauchi, Isao Yashima, Hiroaki Sato, Mikane Nakajima, Yoshiko Dohi, and Kazuhiro Dohi

Subjects
medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, General Medicine, medicine.disease, Gastroenterology, Diabetic nephropathy, Endocrinology, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Gene polymorphism, business, Retinopathy
Published
2000

108. PROMINENT ELEVATION OF PLASMA ADRENOMEDULLIN LEVELS IN SEPTIC PATIENTS

Author

Yoshinori, MURAO, primary, Kenji, NISHIO, additional, Naofumi, DOI, additional, Yasuhiro, AKAI, additional, Hisayuki, TABUSE, additional, Seiji, MIYAMOTO, additional, Kazuhiro, DOHI, additional, Naoto, MINAMINO, additional, Hiroki, SHOJI, additional, Kazuo, KITAMURA, additional, Kenji, KANGAWA, additional, and Hisayuki, MATSUO, additional

Published
1995
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109. Consultants for the American Journal aof Nephrology 1998

Author

Jesus Calviño, Matthew J. Arduino, Gianna Mastroianni Kirsztajn, Yoshiki Sekijima, Christian Mrowka, Shigeru Nakano, J Baltar, Atsushi Horiuchi, Masao Kanauchi, Kendo Kiyosawa, Toshio Kakihara, Kozo Hishimoto, Hirofumi Hasegawa, M. Lucia Ferraz, Daniel Novoa, Elena Pintos, Michael H. Schwenk, Bernhard Heintz, Mark E. Williams, Zora Krivosiková, Toshikazu Kigoshi, Dolores Güimil, Kamlesh Patel, Eduardo Silva, Monique Delorme, Takashi Ohno, Heinz-Günter Sieberth, Edward Kessler, Takafumi Matsumoto, Edmundo P.A. Lopes, Masayuki Iwano, Koji Suzuki, Ling-Yoeu Yang, Wei-Perng Chen, Jürgen Reul, Victor Arcocha, Javier Mardaras, Ann Chen, Ching-Yuang Lin, Chaim Charytan, J Alvarez-Grande, Bahar Bastani, Wolfgang Fierlbeck, August Heidland, Toshihiro Takao, Y.F. Wang, Michele H. Mokrzycki, Elise M. Jochimsen, David Galli, Kazuhiro Dohi, Thomas R. Welch, Johanne Ismaïl, Tohru Umekawa, Satoru Yonekawa, Katarína Šebeková, Toru Yamaguchi, William R. Jarvis, Yuichi Kobayashi, Alexander S. Goldfarb-Rumyantzev, Anne M. Torres, Aparecido B. Pereira, Atsushi Tanaka, Ricardo Sesso, Manabu Takei, Jose A. Diaz-Buxo, Hiroshi Hayakawa, Ahmed Shafik, Shu-ichi Ikeda, Hiroaki Sato, Makoto Uchiyama, Leonard P. Caccamo, Tung-Po Huang, Shuichi Yamaura, Katsuhito Miyazawa, Atsushi Kubo, Bruce Spinowitz, Atsushi Sasaoka, Brenda P. Youngblood, Ryuzo Tsugawa, Hideyuki Kurioka, C.J. Chang, Toshio Yanagihara, Wakako Nanamiya, Lucila M.V. Lopes, Koji Nishiya, XoseM. Lens, Francisco Ortega, Chamberlain I. Obialo, Mika Sakaguchi, Hiroyuki Ito, Leszek Pączek, Teresa Cordal, Elizabeth Czyziw, Tomomasa Oguchi, Hisao Tanaka, Takashi Kurita, Loretta Carson, Than N. Oo, Charles Frenette, Michael C. Braun, Fumio Kurogouchi, T oshiya Takeda, Masanori Hara, Nathan P. Ritchey, Akio Imada, Barbara A. Erickson, Eiji Hirata, J. Dämmrich, A. Laures, Dianne Carter, Kazuhiko Hora, Junya Onozuka, Sonia M. Aguero, Eiichirou Mawatari, Ramón Peces, Jerome I. Tokars, Shiroshi Kitagawa, Mary Gellens, Rafael Romero, Kenzo Uchida, Yasuhiro Akai, Beverly Hernandez, Ichiro Iwamoto, Hiroaki Chikazawa, Kimbroe J. Carter, Rafael A. Navascués, Stephen Lapierre, Domingo Sanchez-Guisande, and Frank Castro

Subjects
Nephrology, medicine.medical_specialty, business.industry, Family medicine, Internal medicine, medicine, business
Published
1998

110. Insulin resistance and pancreatic beta-cell function in patients with hypertensive kidney disease.

Author

Masao Kanauchi, Kuniko Kimura, Yasuhiro Akai, and Yoshihiko Saito

Abstract

Background. Insulin resistance and hyperinsulinaemia have been reported among patients with chronic renal failure. However, little is known concerning insulin sensitivity among patients with hypertensive kidney disease (HKD), especially in those with moderate or severe renal dysfunction.Methods. We examined and compared 30 patients with HKD, 30 normotensive patients with chronic kidney disease (CKD-NT), 30 normal controls and 30 patients with hypertension and normal renal function (HTN). Moderate and severe renal dysfunction were defined according to the K/DOQI definitions (estimated glomerular filtration rates between 15 and 59 ml/min per 1.73 m2). The homeostasis model assessment of insulin resistance (HOMA-R) and three surrogate indexes based on 75 g oral glucose tolerance test results were used to determine insulin sensitivity.Results. A trend to higher HOMA-R values in the HTN and HKD groups than in the other groups was noted, but the difference was not statistically significant. The insulin sensitivity index (ISI) proposed by Stumvoll et al. was significantly lower in the HTN, HKD and CKD-NT groups than in controls and was significantly lower in HKD than in the HTN and CKD-NT groups. The insulin sensitivity index proposed by Gutt et al. was significantly lower in HKD than in the control and HTN groups and showed a trend to being lower in HKD than in CKD-NT. The same patterns prevailed in the oral glucose ISI. We assumed that subjects whose ISI values decreased below the mean value minus 2-SD in the control group manifest apparent insulin resistance. According to this criterion, ∼40% of HKD subjects were in an insulin-resistant state: only <10% of HTN subjects and ∼10–30% of CKD-NT subjects were insulin resistant.Conclusions. HKD with moderate to severe renal dysfunction is associated with insulin resistance. [ABSTRACT FROM AUTHOR]

Published
2004
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111. Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus

Author

Masayuki Iwano, Atsushi Kubo, Hideo Shiiki, Kazuhiro Dohi, Hisayuki Nishioka, Yoshihiro Fujii, Toshihiko Nishino, Yasuhiro Akai, Hideyuki Kurioka, Hiroaki Sato, and Masao Kanauchi

Subjects
Messenger RNA, medicine.medical_specialty, Renal glomerulus, Glomerulonephritis, Biology, medicine.disease, Reverse transcriptase, Diabetic nephropathy, Endocrinology, Nephrology, Diabetes mellitus, Internal medicine, Complementary DNA, Gene expression, medicine
Abstract

Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus. Transforming growth factor-β1 (TGF-β1) is a primary determinant of the mesangial expansion observed in diabetic nephropathy. In this study, we quantitated the levels of intraglomerular TGF-β1 mRNA in patients with diabetes mellitus using a competitive polymerase chain reaction (PCR) method. Renal biopsy specimens were obtained from 29 patients with non-insulin-dependent diabetes mellitus. Total RNA was extracted from the glomeruli and reverse transcribed into cDNA with reverse transcriptase. To prepare samples containing identical amounts of β-actin cDNA (8 pg), we performed competitive PCR by co-amplifying mutant templates of β-actin with a unique Eco RI site. We also used this competitive PCR method to measure TGF-β1 cDNA by co-amplifying mutant templates of TGF-β1. We observed higher expression of TGF-β1 mRNA in glomeruli of patients with diabetic nephropathy as compared with normal glomeruli. Intraglomerular TGF-β1 mRNA was elevated, even in the early stage of diabetic nephropathy. Moreover, levels of intraglomerular TGF-β1 mRNA correlated with values of HbA1c. These data suggest that hyperglycemia induces intraglomerular TGF-β1 mRNA expression in vivo , and that TGF-β1 overproduction may be associated with the progression of diabetic nephropathy.

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112. Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

Author

Yo-ichi Nabeshima, Masaru Matsui, Noboru Konishi, Ken-ichi Samejima, Yoshihiko Saito, Akihiro Imura, Shuhei Yoshimoto, Yasuhiro Akai, Yukinari Yamaguchi, Kimihiko Nakatani, Hirokazu Sakan, Tomohiro Tanaka, Masayuki Iwano, and Osamu Asai

Subjects
Adult, Male, medicine.medical_specialty, Heterozygote, Time Factors, chemistry.chemical_element, Down-Regulation, TRPV Cation Channels, Receptors, Cell Surface, Calcium, Transfection, urologic and male genital diseases, Nephropathy, Diabetes Mellitus, Experimental, Excretion, Diabetic nephropathy, Mice, Young Adult, Internal medicine, Diabetes mellitus, Medicine, Animals, Humans, Hypercalciuria, Diabetic Nephropathies, RNA, Messenger, Kidney Tubules, Distal, Klotho Proteins, Glucuronidase, hypercalciuria, Mice, Knockout, business.industry, hypoxia, diabetic nephropathy, Middle Aged, medicine.disease, Urinary calcium, female genital diseases and pregnancy complications, Mice, Inbred C57BL, Endocrinology, HEK293 Cells, chemistry, Nephrology, Calcium Channels, business, Glomerular hyperfiltration
Abstract

Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption. We studied 31 patients with early diabetic nephropathy and compared them with 31 patients with IgA nephropathy and 7 with minimal change disease. Renal α-Klotho expression was significantly lower and urinary calcium excretion (UCa/UCr) significantly higher in diabetic nephropathy than in IgA nephropathy or minimal change disease. Multiple regression analyses indicated that α-Klotho mRNA was inversely correlated with calcium excretion. We next measured these parameters in a mouse model of streptozotocin (STZ)-induced diabetic nephropathy, characterized by glomerular hyperfiltration, as seen in early diabetic nephropathy. We also confirmed a reduction of renal α-Klotho mRNA down to almost 50% and enhanced calcium excretion in mice with STZ-induced diabetic nephropathy in comparison with nondiabetic mice. Hypercalciuria was exacerbated in heterozygous α-Klotho knockout mice in comparison with wild-type mice, each with STZ-induced diabetic nephropathy. Thus, α-Klotho expression was decreased in distal convoluted tubules in diabetic nephropathy in humans and mice. Renal loss of α-Klotho may affect urinary calcium excretion in early diabetic nephropathy.

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