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In order to obtain 3D printed alumina ceramic cores with isotropic shrinkage, a pore former was added into the photocurable slurry, and combined with an optimization of the sintering procedure. Micron scale pores were observed in the sintered ceramics when the pore former was present compared with the samples without pore former. The addition of the pore former significantly improved the pore interconnectivity and pore size of the 3D printed ceramics, due to the volatilization of the pore former. The resulting shrinkage of the ceramic parts in three directions was more uniform and smaller when they were fabricated using a slurry containing the pore former in comparison to those without pore former. The bulk density, shrinkage, and flexural strength of the ceramics increased with increasing the sintering temperature. Triple sintering significantly improved the flexural strength, and also lead to anisotropic shrinkage of the samples, due to the enhanced binding force between layers deriving from the increased number of sintering cycles. In addition, the triple sintering process enabled healing of the cracks developed during sintering, differently from a single sintering. The use of a pore former and the triple sintering procedure provides a new optimized strategy for the fabrication of 3D printed ceramic cores with suitable properties.

Cancer pain is the most prevalent symptom experienced by cancer patients. It substantially impacts a patient’s long-term physical and emotional health, making it a pressing issue that must be addressed. Purinergic receptor P2X7 (P2X7R) is a widely distributed and potent non-selective ATP-gated ion channel that regulates tumor proliferation, chronic pain, and the formation of inflammatory lesions in the central nervous system. P2X7R plays an essential role in cancer pain and complications related to cancer pain including depression and opioid tolerance. This review focuses on the structure and distribution of P2X7R, its role in diverse tissues in cancer pain, and the application of P2X7R antagonists in the treatment of cancer pain to propose new ideas for cancer pain management.

Bone cancer pain (BCP) is the most severe and intractable type of cancer pain. Emerging evidence has demonstrated that activated microglia in the spinal cord could release a series of neurotoxic substances to stimulate neurons and form neuronal sensitization. The P2X7 receptor (P2X7R) is a nonselective ATP-gated ion channel predominantly present in microglia in the spinal cord as the key modulator of microglial activity. However, the specific effect and underlying molecular mechanism of P2X7R in BCP have not yet been elucidated.This study aimed at investigating whether P2X7R-induced BCP by regulating microglial activity through NLRP3/IL-1beta signaling involvement in BCP.Controlled animal study.A BCP animal model was established by injecting Walker-256 breast cancer cells into the tibia of female rats. Fifty percent paw withdrawal thresholds (50% PWTs), number of spontaneous flinches (NSF), and limb use scores were used to evaluate behavior in rats. P2X7R inhibitor brilliant blue G (BBG) was used to assess the role of P2X7R in BCP-induced NLRP3 inflammasome activation. Western blot, RT-PCR, and immunofluorescence were used for quantitative comparison. In vitro, BV2 cells were treated with lipopolysaccharide (LPS) and BzATP, in the presence or absence of P2X7 siRNA, with nigericin (an agonist of the NLRP3 inflammasome) to further study the mechanism of P2X7R regulate NLRP3/IL-1beta signaling.The inhibition of spinal P2X7R with BBG could effectively inhibit BCP due to suppressing the expression of NF-kappaB p-p65, NLRP3 inflammasome formation, and downstream pain factors IL-1beta. Furthermore, P2X7 siRNA could reduce microglial activity, the nuclear translocation of NF-kappaB, and the synthesis of NLRP3 and IL-1beta in BV2 cells. In addition, nigericin partially reversed the ameliorating effect of P2X7 siRNA on BV2 cells induced by LPS and BzATP.BBG could relieve BCP but not improve the destruction of bone, which may be related to the specificity of inoculated cells. Further mechanisms should be investigated.These findings suggest that targeting the microglial P2X7R activated NLRP3/IL-1beta signaling pathway could serve as a potential strategy for BCP treatment.

Recently, thermophilic Thermoanaerobacterium species have attracted increasing attentions in consolidated bioprocessing (CBP), which can directly utilize lignocellulosic materials for biofuels production. Compared to the mesophilic process, thermophilic process shows greater prospects in CBP due to its relatively highly efficiency of lignocellulose degradation. In addition, thermophilic conditions can avoid microbial contamination, reduce the cooling costs, and further facilitate the downstream product recovery. However, only few reviews specifically focused on the microbial applications of thermophilic Thermoanaerobacterium species in lignocellulosic biorefinery. Accordingly, this review will comprehensively summarize the recent advances of Thermoanaerobacterium species in lignocellulosic biorefinery, including their secreted xylanases and bioenergy production. Furthermore, the co-culture can significantly reduce the metabolic burden and achieve the more complex work, which will be discussed as the further perspectives. KEY POINTS: • Thermoanaerobacterium species, promising chassis for lignocellulosic biorefinery. • Potential capability of hemicellulose degradation for Thermoanaerobacterium species. • Efficient bioenergy production by Thermoanaerobacterium species through metabolic engineering.

Ammonium salt of diethylene triamine penta methylene phosphonic acid (ADTPMPA), a novel flame retardant, was synthesized and grafted on the lyocell fabric to obtain a kind of flame retardant lyocell fabric (FR-lyocell). Then FR-lyocell was coated by Ag nanoparticles (Ag NPs) to fabricate flame retardant and antibacterial lyocell fabric (FR-Ag-lyocell). The elemental composition, surface morphology, combustion behavior and antibacterial activity of the lyocell fabric before and after modification were investigated. The flame retardant and antibacterial mechanism of FR-Ag-lyocell fabric was also analyzed. The limiting oxygen index (LOI) values of FR-Ag-lyocell fabric before and after 20 laundering cycles (LCs) reached 44.8% and 31.3%, respectively. The treated lyocell fabric possessed lower peak of heat release rate (pHRR) and total heat release (THR) values compared with control lyocell fabric. The FR-Ag-lyocell fabric exhibited excellent antimicrobial ability against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), even after 10 LCs. These results indicated that FR-Ag-lyocell fabric had durable flame retardant and antibacterial properties.

A novel effective halogen-free flame retardant (FR) rich in phosphorus (P) and nitrogen (N) was synthesized via Mannich and esterification reaction of ethanolamine, glyoxal, phosphoric acid and urea, and used for the preparation of durable flame retardant lyocell fabric (FR-lyocell). Its chemical structure was characterized by Fourier transform infrared spectra, 1H and 31P nuclear magnetic resonance spectra. Inductively coupled plasma emission spectrometry and elemental analysis were conducted to test the phosphorous, carbon and nitrogen contents. The results confirmed that the FR was successfully synthesized and grafted on the lyocell fabric via firm P–O–C covalent bonds. The limiting oxygen index of the FR-lyocell treated with 30 wt% flame retardant finishing solution is 44.6%, demonstrating high efficiency flame retardancy. The thermo-gravimetric analysis indicated that FR-lyocell degraded preferentially than that of the control sample and the char residue was 38.8 wt% at 800 °C in N2 atmosphere. In addition, the cone calorimeter test revealed that FR-lyocell could not be ignited and the peak of heat release rate was much lower than that of original specimen. Furthermore, the char residue of FR-lyocell is compact and the ID/IG value is 0.771, exhibiting a super degree of carbonization. Moreover, TG-IR result revealed that FR played dual flame-retardant effect in the gaseous and condensed phases. The flame retardant finishing has a negligible impact on the mechanical properties of the fibers. In summary, FR-lyocell exhibits excellent flame retardancy and superior char forming capability, which is suitable for the preparation of flame retardant lyocell fibers.

Stereolithography based-3D printing technology requires ceramic slurries with high solid content and low viscosity to prevent the formation of cracks, holes, warping, and other defects in sintered ceramic parts. In this study, several approaches based on optimization of alumina powder and coupling agent were explored to improve the solid content of ceramic slurries. It was shown that slurries containing γ-Al2O3 reached solid content of only 22.5 wt% and viscosity of 15,199 mPa·s. By comparison, slurries composed of α-Al2O3 reached higher solid content of 75 wt% and viscosity of 12,780 mPa·s. Three types of coupling agents, namely (3-Aminopropyl) triethoxysilane, (Aminoethylamino) propyldimethoxymethylsilane and 3-(Trimethoxysilyl) propyl methacrylate (abbreviated as E, F and G, respectively) were used to reduce the viscosity of the slurries. The addition of 10 wt% G led to slurry solid content reaching 82 wt% and viscosity of 860 m·Pas. The significant decrease in viscosity was mainly attributed to the presence of bifunctional hydrolyzable groups in G, which could well attach to alumina. On the other hand, the presence of organo-functional groups might also well attach to the photosensitive resin. The ceramics prepared with γ-Al2O3 exhibited numerous pores in both intraparticle and intergranular while those obtained with α-Al2O3 showed pores in only intergranular. The porous structure in γ-Al2O3 occupied large space, leading to low solid content. Ceramics prepared with 75 wt% solid content possessed flexural strength of 29.3 MPa, bulk density of 2.3 g/cm3 and open porosity of 39.8 %. By comparison, ceramics prepared with 82 % solid content showed flexural strength of 45.0 MPa. In sum, these findings look promising for future preparation of high-solid content 3D printed ceramic slurries for complex ceramics, such as ceramic cores.

Herein, alumina green bodies are fabricated by three dimensional (3D) printing technology, then, the influence of debinding holding time under vacuum and argon on mechanical properties is systematically investigated by comparing the changes in microstructure, bulk density, open porosity, grain connection situation and flexural strength of ceramics. The flexural strength of alumina ceramics acquired the maximum values of 26.4 ± 0.7 MPa and 25.1 ± 0.5 MPa after debinding under vacuum and argon for 120 min and 180 min, respectively. However, the alumina ceramics rendered the flexural strength of 19.4 ± 0.6 MPa and 9.5 ± 0.4 MPa under vacuum and argon without extended holding time, respectively. The relatively low mechanical properties can be mainly attributed to the weak interlayer binding force, which is caused by layer-by-layer forming mode during 3D printing process and anisotropic shrinkage during the sintering process. Moreover, the alumina ceramics exhibited moderate bulk density and open porosity of 2.4 g/cm3 and 42% after the sintering process, respectively, which are mainly influenced by the microstructural evolution of alumina ceramics during thermal treatment. Also, the diffusion of gases is achieved by curing of photosensitive resin and influenced by different holding times during debinding, affecting the mechanical properties of sintered ceramics. The mechanical properties of as-sintered ceramics are suitable for the utilization of ceramic cores in the manufacturing of hollow blades.

Oncogene‐like effects of TMEM92‐AS1: LncRNA TMEM92‐AS1 regulates the expression of downstream target gene CCL5 by binding with YBX1 protein to play the role of oncogene and affects prognosis of patients with gastric cancer. TMEM92‐AS1 may also promote the secretion of G‐CSF by tumour cells to increase the level of neutrophils in the peripheral blood., Numerous studies have revealed that long noncoding RNAs (lncRNAs) with oncogene properties play vital roles in gastric cancer (GC). In this study, we aimed to elucidate the function of TMEM92‐AS1 in GC progression and to investigate its underlying mechanisms. TMEM92‐AS1 was filtered from the Gene Expression Omnibus database. GC tissues and adjacent normal tissues were used to detect the expression level of TMEM92‐AS1. MTT, colony‐formation assays, Edu, cell cycle, apoptosis and subcutaneous tumour formation assays were used to detect the role of TMEM92‐AS1 in cell function. RNA transcriptome sequencing was used to seek downstream target genes. Reverse transcription (RT)‐qPCR, western blot, RNA and chromatin immunoprecipitation assays were used to investigate the mechanisms involved. TMEM92‐AS1 was significantly overexpressed in GC tissues and correlated with poor overall survival and disease‐free survival. Furthermore, TMEM92‐AS1 promoted GC cell proliferation and migration in vitro and tumorigenic ability in vivo. RNA transcriptome sequence analysis revealed a potential downstream target gene, C‐C motif chemokine ligand 5 (CCL5), and a mechanistic study found that TMEM92‐AS1 regulated CCL5 by binding to the transcription factor Y‐box binding protein 1(YBX1), which has oncogene properties. In addition, TMEM92‐AS1 was found to be associated with peripheral blood leukocyte counts, especially neutrophils. Further investigation found that TMEM92‐AS1 may affect leukocytes via regulation of the expression of granulocyte colony‐stimulating factor in GC tissues. Our data provide an in‐depth insight into the mechanism behind the lncRNA TMEM92‐AS1, how it promotes GC progression and the possible mechanism in affecting peripheral leukocyte counts. Therefore, TMEM92‐AS1 is a potential target for GC individualized therapy and prognostic assessment.

Metal-organic frameworks (MOFs) exhibit highly designable properties and have been used in wide applications. To further improve their performance, the modification of MOFs is an effective method. However, the modification process is usually complicated. Besides, the sustainable use of MOFs is difficult to achieve due to the complicated recycling treatment. Herein, we designed a polyethyleneimine (PEI)-modified NH2-MIL-101(Al) composite (PEI@NH2-MIL-101(Al)). This composite showed excellent dye removal performance of methyl orange (MO, 89.4%) and Direct Red 80 (DR80, 99.8%). Remarkably, the dye removal application of PEI@NH2-MIL-101(Al) also acted as a modification process toward flame retardant application. Thus, the dye-adsorbed PEI@NH2-MIL-101(Al) composite (MO-PEI@NH2-MIL-101(Al) and DR80-PEI@NH2-MIL-101(Al)) was sustainably used as an effective flame retardant for an epoxy resin (EP) at low additions (4.0 wt %). The limiting oxygen values of EP/MO-PEI@NH2-MIL-101(Al) and EP/DR80-PEI@NH2-MIL-101(Al) increased to 26.5 and 26.7%, respectively. The heat release and the smoke production of dyes-PEI@NH2-MIL-101(Al)/EP were greatly reduced compared with those of EP. This strategy provides a simple and effective modification method for MOFs. Meanwhile, the modified MOF composite can achieve sustainable application, giving full play to the advantages of MOFs.

Stereolithography (SL) was used to form alumina ceramic cores. The effect of sintering temperature on the microstructure and mechanical properties of the alumina ceramics are investigated, which were sintered in vacuum. The results indicate that, as the sintering temperature increased the particle size of alumina slightly increased, and the interlayer spacing first decreased and then increased. The open porosity of alumina ceramics significantly decreased as the sintering temperature in vacuum increased. The flexural strength and hardness increased as the sintering temperature increased. When sintered at 1150 °C, the flexural strength was found to be 33.7 MPa, the shrinkage was 2.3 %, 2.4 %, and 5.3 % in the X, Y, and Z directions, respectively, and the open porosity was 37.9 %. These results are similar to those found from sintering at 1280 °C in air.

Background Schizophrenia is a severe, heritable, and refractory psychiatric disorder. Several studies have shown that the disrupted in schizophrenia 1 (DISC1) gene is closely associated with schizophrenia by its role in neuronal morphology, synaptic function, brain development, and dopamine homeostasis etc. This study intended to investigate the expression levels of DISC1 gene in schizophrenia patients compared with healthy controls, and the expression variation of DISC1 gene before and after antipsychotic treatment in schizophrenia patients. Methods In this study, we compared DISC1 expression levels in blood of 48 healthy controls, and 32 schizophrenia patients before and after 12 weeks of antipsychotic treatment using real-time quantitative PCR (RT-qPCR) analysis. Results The expression levels of DISC1 gene in peripheral blood mononuclear cells of schizophrenia patients before antipsychotic treatment were higher than those in healthy controls (P DISC1 gene in peripheral blood mononuclear cells of schizophrenia patients still remained increased (P Conclusions Our study provided further support for the involvement of DISC1 in the development of schizophrenia.

Solvents assist in the debinding of stereolithography-based 3D-printed alumina green bodies. The green bodies subsequently undergo thermal debinding and sintering to obtain alumina ceramics. In this study, several solvents were tested, including polyethylene glycol, oxalic acid, ammonium hydroxide, ethyl alcohol, methyl methacrylate, butyl acetate, dimethyl carbonate, methanol, ethyl acetate, and sec-butyl alcohol. The tested solvents during the debinding process showed different effects on microstructure and properties of 3D-printed alumina ceramics due to the variable aspects of their solubility toward the binders. The microstructure of the samples changed significantly after green bodies underwent solvent debinding, thermal debinding, and sintering, leading to loose spongy structures, porous aggregates, and compact structures, respectively. Shrinkage, bulk density, and open porosity changed slightly due to the debinding function of different solvents. Polyethylene glycol-impregnated samples displayed the minimum shrinkage in length direction (5.3%). Ethyl alcohol-impregnated sample showed minimum shrinkage in width (4.8%) and height (11.5%) directions. Ammonium hydroxide-impregnated samples exhibited minimum bulk density (2.8 g/cm3) and maximum open porosity (28.3%). Dimethyl carbonate-impregnated samples presented minimum flexural strength (32.6 MPa), and oxalic acid-impregnated samples revealed maximum flexural strength (63.4 MPa). In sum, the as-obtained ceramics would be used as ceramic cores for hollow blades in aircraft engines due to their high open porosity and moderate flexural strength.

In this work, 3D printed alumina green bodies were subjected to burying sintering using different alumina particle sizes to obtain ceramics. The effects of buried alumina particle size on the microstructure and properties of the sintered ceramics were investigated. The results showed that the shrinkage, density, and flexural strength of the ceramics increased as the alumina particle size increased from 5 μm to 1000 μm, but decreased as the particle size further increased to 2000 μm. The open porosity decreased as the alumina particle size increased from 5 μm to 1000 μm, but increased as the particle size further increased to 2000 μm. The sintered alumina ceramics were composed of layers, and interlayering spacing phenomenon was observed. The optimum particle size of buried alumina was 1000 μm, which resulted in sintered ceramics with shrinkage of 2.2 % in X direction, 2.1 % in Y direction, and 3.8 % in Z direction, density of 2.42 g/cm3, open porosity of 41.5 %, and flexural strength of 25.8 MPa. Buried powder sintering helped to support the green bodies, and also restrained the deformation of the sintered ceramics because the volatilization of the cured photosensitive resin compensated the vapor pressure in the environment. Compared with the ceramics sintered without buried powder, the ceramics subjected to burying sintering exhibited smaller shrinkage, lower bulk density, and higher open porosity. These features could not only diminish the deformation of the sintered ceramics, but could also facilitate the removal process in the manufacturing of hollow blades.

Growing evidence indicated that single nucleotide polymorphisms (SNPs) in the apolipoprotein E (APOE) gene are related to increase the risk of many inflammatory-related diseases. However, few genetic studies have associated the APOE gene polymorphism with sepsis. This study was to investigate the clinical relevance of the APOE gene polymorphism in the onset and progression of sepsis. A multicenter case–control association study with a large sample size (601 septic patients and 699 healthy individuals) was conducted. Clinical data showed that the APOEε4 allele was overrepresented among all patients with septic shock (p = 0.031) compared with sepsis subtype, suggesting that APOEε4 allele may associated with increased susceptibility to the progression of sepsis. Moreover, the APOE mRNA levels decreased after lipopolysaccharide (LPS) stimulation in cells in culture. Then 21 healthy individuals to extract PBMC for genotype grouping (APOE4+ group 8; APOE4− group 13) was selected to evaluate the effect on APOE level, and results showed that the expression level of APOE in APOE4+ group and APOE4− group did not differ in mRNA levels after an LPS challenge, but the protein levels in APOE4+ group decreased slower than that in APOE4− group, and this process was accompanied by the upregulation of proinflammatory cytokines. These results provide evidence that the APOEε4 allele might be associated with the development of sepsis and a potential risk factor that can be used in the prognosis of sepsis.

Ceramic green bodies fabricated by stereolithography-based three-dimensional printing technology often have high loading of ultraviolet curable resins, which produce undesirable phenomena such as cracking, deformation, and blistering during the debinding process. Results showed that compared to argon and vacuum, air atmosphere provided higher flexural strength owing to the elevated density. The differences in microstructure between specimens prepared under these atmospheres were attributed to exothermic oxidation reactions occurred under air when compared to endothermic pyrolysis reactions under vacuum and argon. The debinding atmosphere showed little effect on crystallite size due to the elevated sintering temperature, which would determine the final crystallite size of Al2O3. Debinding under air atmosphere resulted in flexural strength of 176.69 MPa and open porosity of 23.4%. The flexural strength of the ceramics debinded in air was 21.6% higher than the ceramics debinded in argon atmosphere.

Highlights • The prevalence of depression was increased (6.21%) in quarantined subjects. • Depressed group were younger, less educated and married than non-depressed group. • Depression was positively correlated with anxiety, poor sleep quality and PTSS. • It is necessary to take strategies to improve the depression of quarantined subjects., Background The COVID-19 outbreak has brought tremendous psychological pressure to the general population, which may lead to depression. Therefore, this study aim to evaluate the prevalence and clinical correlates of depressive symptoms in the general population quarantined during the COVID-19 outbreak in Shenzhen. Methods 2237 quarantined general individuals participated in this cross-sectional study from February 14 to March 4, 2020, during their 14 days quarantine. They completed the Zung's Self-Rating Depression Scale (SDS) for depression, Zung's self-rating anxiety scale (SAS) for anxiety, the Pittsburgh Sleep Quality Index (PSQI) for sleep quality, and the Impact of Events Scale-Revised (IES-R) for post-traumatic stress symptoms (PTSS). Results The prevalence of depressive symptom was 6.21% in quarantined individuals. The depressed group were younger, less married and educated, and had higher SAS, PSQI, IES-R total scores (all p

Introduction Inflammatory breast cancer (IBC) is a rare type of breast cancer with poor prognosis, and the pathogenesis of this life-threatening disease is yet to be fully elucidated. This study aims to identify key genes of IBC, which could be potential diagnostic or therapeutic targets. Methods Four datasets GSE5847, GSE22597, GSE23720, and GSE45581 were downloaded from the Gene Expression Omnibus (GEO) and differential expression analysis was performed. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to understand the potential bio-functions of the differentially expressed genes (DEGs). Protein-protein interaction (PPI) network was constructed for functional modules analysis and hub genes identification, and TCGA survival analysis and qRT-PCR of clinical samples were used to further explore and validate the effect of hub genes on IBC. Results A total of 114 DEGs were identified from the GEO datasets. GO and KEGG analyses showed that the DEGs were mainly enriched in oncogenesis and cell adhesion. From the PPI network, we screened out five hub genes, including PTPRC, IL6, SELL, CD40, and SPN. Survival analysis and expression validation verified the robustness of the hub genes. Discussion The present study provides new insight into the understanding of IBC pathogenesis and the identified hub genes may serve as potential targets for diagnosis and treatment.

Lyocell fibers, one of the green and regenerated cellulose fibers, are widely used in the textile fields. However, lyocell fibers are highly flammable which will cause fire accidents. Herein, a novel biomass-based flame retardant derived from vitamin C (VCFR) was designed and synthesized. Then, the lyocell fabrics were finished with VCFR through esterification to fabricate durable flame retardant lyocell fabrics (RF-lyocell). The structure of the different fabrics was characterized by X-ray photoelectron spectroscopy and Fourier transform infrared analysis analysis. The limiting oxygen index value of the FR-lyocell was as high as 39.8%, which still remained 26.4% after 30 washing cycles, indicating excellent flame retardancy and durability. Thermogravimetric-Fourier transform infrared analysis proved that non-combustion compounds, such as CO2 and water were generated, and provided an obvious flame retardant effect in the gas phase. Cone calorimeter tests showed that the peak of heat release rate and total heat release had a reduction of 89.5% and 54.5%, respectively. These results suggested that VCFR can be used as an effective biomass-based flame retardant for lyocell fabrics.

Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing. The effects of sintering temperature on microstructure and physical and mechanical properties were investigated. The results show that the average particle size, shrinkage, bulk density, crystallite size, flexural strength, Vickers hardness, and nanoindentation hardness increased with the increase in sintering temperature, whereas the open porosity decreased with increasing sintering temperature. No change was observed in phase composition, chemical bond, atomic ratio, and surface roughness. For the sintered samples, the shrinkage in Z direction is much greater than that in X or Y direction. The optimum sintering temperature in argon atmosphere is 1350 °C with a shrinkage of 3.0%, 3.2%, and 5.5% in X, Y, and Z directions, respectively, flexural strength of 26.7 MPa, Vickers hardness of 198.5 HV, nanoindentation hardness of 33.1 GPa, bulk density of 2.5 g/cm3, and open porosity of 33.8%. The optimum sintering temperature was 70 °C higher than that sintering in air atmosphere when achieved the similar properties.

The existing multimedia wireless network security detection technology cannot meet the requirements of wireless network security detection. Therefore, based on the special security requirements of multimedia wireless networks, this paper constructed a multimedia wireless network security detection system that meets the actual situation of the organization. The system was designed using the B/S architecture and used Django as the framework for system development. The system presentation layer mainly presents the system page to the user and passes the user request. Simultaneously, in this paper, the application of PrefixSpan algorithm in anomaly detection was studied and experimental analysis was carried out. The experimental results are in line with expectations. This verifies the effectiveness of the proposed system and provides a theoretical reference for subsequent related research.

The effect of heating rates during vacuum debinding on the microstructure and mechanical properties of alumina ceramics are discussed in this paper. The three-dimensional (3D)-printed alumina ceramics examined in this study were found to have a layered structure, and interlayer spacing increased as the heating rate increased. The pore diameter, shrinkage, flexural strength and hardness were found to decrease as the heating rate increased due to weak interfacial bonding between alumina particles. Shrinkage was found to be much larger along the Z direction than along the X or Y directions due to the layer-by-layer forming mode during 3D printing. 0.5 °C·min−1 is considered the optimum heating rate, yielding ceramics with interlayer spacing of 0.65 µm, shrinkage of 2.6%, 2.3% and 4.0% along the X, Y and Z directions, respectively, flexural strength of 27.5 MPa, hardness of 29.8 GPa, Vickers hardness of HV 266.5, pore diameter of 356.8 nm, bulk density of 2.5 g·cm−3, and open porosity of 38.4%. The debinding procedure used in this study could be used to produce a high-quality ceramic which can be used for fabricating alumina ceramic cores.

The use of multipronged measures, including traditional Chinese medicine (TCM), has greatly increased in response to the COVID-19 pandemic, and we found the use of TCM and is positively correlated with the regional cure rate in China (R=0.77, P

Although applications of the integrated ultrafiltration (UF) membrane have been investigated for years, most studies have been conducted at the lab scale. Here, a case study on the integrated Fe-based floc-UF process was presented. To enhance membrane performance, both pre-filtration (bag filter) and pre-oxidation were used as pretreatments to remove particles and inhibit the development of microorganisms. Results showed that the integrated process operated stably with pre-treatments, and the UF membrane fouling behavior could be divided into three different phases: slow increase rate (phase I), medium increase rate (phase II), and fast increase rate (phase III). In comparison to those in phases II and III, both natural organic matters and colloids were the main membrane fouling mechanisms during phase I, as the pollutants were not successfully removed by flocs initially. With the continuous injection of flocs, a loose cake layer became the main fouling mechanism during phase II, resulting in the deterioration of membrane fouling. During phase III, however, microorganisms (e.g., Proteobacteria) were inevitably nourished within the cake layer and played an important role in aggravating the degree of membrane fouling. During this integrated membrane-based process, several operating factors, including floc concentration, sludge discharge frequency, and the aeration rate during backwashing, played important roles in determining membrane performance. In addition, except for oxygen consumption, all the effluent quality parameters met the drinking water criteria followed in China (GB5749-2006).

The widespread use of cross-linked polyethylene (XLPE) as insulation in cables may be attributed to its outstanding mechanical and dielectric properties. In order to quantitatively evaluate the insulation status of XLPE after thermal ageing, an accelerated thermal ageing experimental platform is established. Polarization and depolarization current (PDC) as well as elongation at break of XLPE insulation under different ageing durations are measured. XLPE insulation state is determined by the elongation at break retention rate (ER%). Based on the extended Debye model, the paper proposed the stable relaxation charge quantity and the dissipation factor at 0.1 Hz to evaluate the insulation state of XLPE. The results show that the ER% of XLPE insulation decreases with the growth of ageing degree. The polarization and depolarization current of XLPE insulation will increase obviously with thermal ageing. Conductivity and trap level density will also increase. The number of branches of the extended Debye model increases, and new polarization types appear. Stable relaxation charge quantity and dissipation factor at 0.1 Hz proposed in this paper have a good fitting relationship with ER% of XLPE insulation, which can evaluate the thermal ageing state of XLPE insulation effectively.

Background Interleukin-18 (IL-18) may participate in the development of major depressive disorder, but the specific mechanism remains unclear. This study aimed to explore whether IL-18 correlates with areas of the brain associated with depression. Methods Using a case–control design, 68 subjects (34 patients and 34 healthy controls) underwent clinical assessment, blood sampling, and resting-state functional Magnetic Resonance Imaging (fMRI). The total Hamilton depression-17 (HAMD-17) score was used to assess depression severity. Enzyme-linked immunosorbent assay (ELISA) was used to detect IL-18 levels. Rest-state fMRI was conducted to explore spontaneous brain activity. Results The level of IL-18 was higher in patients with depression in comparison with healthy controls. IL-18 was negatively correlated with degree centrality of the left posterior cingulate gyrus in the depression patient group, but no correlation was found in the healthy control group. Conclusion This study suggests the involvement of IL-18 in the pathophysiological mechanism for depression and interference with brain activity.