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451 results on '"Yang, Soo-Jin"'

113. The Staphylococcus aureus cidAB operon: evaluation of its role in regulation of murein hydrolase activity and penicillin tolerance

Author

Rice, Kelly C., Firek, Brian A., Nelson, Jeremy B., Yang, Soo-Jin, Patton, Toni G., and Bayles, Kenneth W.

Subjects
Bacteriology -- Research, Staphylococcus aureus -- Physiological aspects, Staphylococcus aureus -- Genetic aspects, Operons -- Genetic aspects, Operons -- Physiological aspects, Genetic regulation -- Physiological aspects, Penicillin -- Physiological aspects, Gene expression -- Physiological aspects, Biological sciences
Abstract

Research has been conducted on Staphylococcus aureus lrgAB operon which inhibits murein hydrolase activity and decreases sensitivity to penicillin-induced killing. The authors suggest that cidAB operon encodes a holin-like counterpart of lrgAB and increases murein hydrolase activity and sensitivity to penicillin-induced killing.

Published
2003

114. Voglibose-mediated alterations in neurometabolomic profiles in the hypothalamus of high-fat diet-fed mice.

Author

Yang, Soo Jin, Do, Hyun Ju, Jung, Youngae, Hwang, Geum-Sook, and Shin, Min-Jeong

Subjects
*HYPOTHALAMUS, *LEUCINE, *GLUTAMINE, *ALPHA-glucosidases, *AMINO acids, *MICE, *INGESTION, *WEIGHT gain
Abstract

The alpha-glucosidase inhibitor voglibose (VO) was recently reported to have a protective effect against weight gain as well as affect various metabolic changes related to food intake and gut–brain signaling. We hypothesized that VO prevents weight gain by altering neurometabolome profiles in the hypothalamus to reduce food intake. To test this hypothesis, we assessed metabolite profiles in the hypothalamus of standard diet- or high-fat (HF) diet-fed mice in the absence or presence of VO. In total, 29 male C57BL/6 mice were divided into 3 groups: (1) lean control, (2) HF, and (3) HF + VO. Vehicle or VO was administered for 12 weeks. The results showed that there were alterations in levels of metabolites across several metabolic pathways in the hypothalamus. VO treatment increased levels of many amino acids including arginine, glutamine, histidine, isoleucine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine in the hypothalamus. In addition, levels of 2-hydroxy-2-methyl-butyric acid in the hypothalamus were significantly increased after VO administration in HF diet-fed mice. Among lipid metabolites, levels of fatty acids were higher in the hypothalamus of VO-treated mice than in that of HF diet-fed mice. In terms of the energy status, the ATP/ADP ratio was higher in the hypothalamus of VO-treated mice (P < 0.001), thereby indicating an energy surplus. In conclusion, VO supplementation altered metabolite profiles in the hypothalamus to enhance catabolism, which is possibly responsible for the hypophagic effect of VO in HF diet-fed mice. [ABSTRACT FROM AUTHOR]

Published
2019
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126. Daptomycin Susceptibility of Clinical Isolates in Invasive Staphylcoccus aureus Infections in Korean Hospitals: Can Resistance to Daptomycin Occur Without Previous Exposure?

Author

Hwang, Joo-Hee, primary, Nam, Eun Young, additional, Yang, Soo-Jin, additional, Kim, Eu Suk, additional, Park, Kyung-Hwa, additional, Jung, Sook-in, additional, Yoon, Nara, additional, Kim, Dong-Min, additional, Lee, Chang-Seop, additional, Jang, Hee-Chang, additional, Park, Yoonseon, additional, Lee, Kkot Sil, additional, Kwak, Yee Gyung, additional, Lee, Jae Hoon, additional, Park, Seong Yeon, additional, Kim, Moonsuk, additional, Song, Kyoung-Ho, additional, and Kim, Hong Bin, additional

Published
2016
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127. Emergence of Daptomycin-Nonsusceptible Methicillin-Resistant <italic>Staphylococcus aureus</italic> Clinical Isolates Among Daptomycin-Naive Patients in Korea.

Author

Nam, Eun Young, Yang, Soo-Jin, Kim, Eu Suk, Cho, Jeong Eun, Park, Kyung-Hwa, Jung, Sook-In, Yoon, Nara, Kim, Dong-Min, Lee, Chang-Seop, Jang, Hee-Chang, Park, Yoonseon, Lee, Kkot Sil, Kwak, Yee Gyung, Lee, Jae Hoon, Park, Seong Yeon, Hwang, Joo-Hee, Kim, Moonsuk, Song, Kyoung-Ho, Kim, Hong Bin, and the Korea Infectious Diseases (KIND) Study Group

Subjects
*METHICILLIN-resistant staphylococcus aureus, *BACTERIAL diseases, *LIPOPEPTIDE antibiotics, *PHENOTYPES, *LONGITUDINAL method
Abstract

This study was conducted to assess emergence of daptomycin-nonsusceptible (DAP-NS) phenotype in DAP-naive patients with invasive Staphylococcus aureus (ISA) infections in Korea. A total of 208 S. aureus clinical isolates were selected from a previous prospective study on ISA infections and evaluated for DAP-NS. Although DAP has never been introduced in Korea, five DAP-NS S. aureus strains (2.4%) were identified among 208 S. aureus strains collected from ISA infections. The DAP-NS phenotype was observed only in methicillin-resistant S. aureus (MRSA) strains, but not in methicillin-susceptible S. aureus strains. One DAP-NS MRSA strain belonged to sequence type 72 (ST72) and four were ST5 MRSA strains, three of which were heteroresistant vancomycin (VAN)-intermediate S. aureus. All these five DAP-NS MRSA strains were from healthcare-associated infections without prior exposure to VAN within 30 days. While the ST72 MRSA strain exhibited DAP-NS phenotype via charge repulsion mechanism, four ST5 DAP-NS S. aureus strains had charge-independent DAP-NS mechanism. None of the five DAP-NS strains displayed significant increase in cell wall thickness, indicating that altered cell wall thickness was not associated with the observed DAP-NS phenotype. [ABSTRACT FROM AUTHOR]

Published
2018
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139. Genetic alterations responsible for reduced susceptibility to vancomycin in community-associated MRSA strains of ST72.

Author

Jin Yang Baek, Doo Ryeon Chung, Kwan Soo Ko, So Hyun Kim, Soo-Jin Yang, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song, Baek, Jin Yang, Chung, Doo Ryeon, Ko, Kwan Soo, Kim, So Hyun, Yang, Soo-Jin, Kang, Cheol-In, Peck, Kyong Ran, and Song, Jae-Hoon

Subjects
METHICILLIN-resistant staphylococcus aureus, VANCOMYCIN, MICROBIAL sensitivity tests, BACTERIAL mutation, MESSENGER RNA, RIFAMPIN, THERAPEUTICS, ANTIBIOTICS, BACTERIAL proteins, CELLS, ELECTRON microscopy, GENETIC mutation, STAPHYLOCOCCAL diseases, PHENOTYPES, DNA-binding proteins, COMMUNITY-acquired infections, TREATMENT effectiveness, GENOTYPES, PHARMACODYNAMICS
Abstract

Objectives: We previously reported the first case of vancomycin treatment failure due to development of vancomycin-intermediate resistance in a patient with an MRSA of ST72, a community genotype in Korea. We investigated two isogenic MRSA strains from this patient, who experienced treatment failure with vancomycin and rifampicin.Methods: We tracked the genetic alterations that confer reduced susceptibility to vancomycin on those two isogenic MRSA strains by WGS.Results: Five non-synonymous mutations were identified, including rpoB (H481Y), dprA (G196C), femA (F92C), vraR (E127K) and agrC (E391stop). We further studied the role of a mutation of vraR in reduced susceptibility to vancomycin. Introduction of the mutated vraR (E127K) into a vancomycin-susceptible Staphylococcus aureus strain resulted in an increase in vraSR mRNA expression and vancomycin MIC and development of the hetero-VISA phenotype, which was confirmed by the population analysis profile (PAP)/AUC. Electron microscopy showed increased cell wall thickness in the strains with mutated vraR.Conclusions: Based on the genomic data, molecular experiments and PAP and cell wall analyses, we propose that a single mutation of vraR is associated with the reduced susceptibility to vancomycin in MRSA and further treatment failure. [ABSTRACT FROM AUTHOR]

Published
2017
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