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Dynamization, increasing the interfragmentary movement (IFM) by reducing the fixation stiffness from a rigid to a more flexible condition, is widely used clinically to promote fracture healing. However, it remains unknown how dynamization degree (relative change in fixation stiffness/IFM from a rigid to a flexible fixation) affects bone healing at various stages. To address this issue, we used a fuzzy logic‐based mechano‐regulated tissue differentiation algorithm on published experimental data from a sheep osteotomy healing model. We applied a varied degree of dynamization, from 0 (fully rigid fixation) to 0.9 (90% reduction in stiffness relative to the rigid fixation) after 1, 2, 3, and 4 weeks of osteotomy (R1wF, R2wF, R3wF, and R4wF) and computationally evaluated bone regeneration and biomechanical integrity over the healing process of 8 weeks. Compared with the constant rigid fixation, early dynamization (R1wF and R2wF) led to delays in bone bridging and biomechanical recovery of the osteotomized bone. However, the effect of early dynamization on healing was dependent of the degree of dynamization. Specifically, a higher dynamization degree (e.g., 0.9 for R1wF) led to a prolonged delay in bone bridging and largely unrecovered bending stiffness (48% relative to the intact bone), whereas a moderate degree of dynamization (e.g., 0.5 or 0.7) significantly enhanced bone formation and biomechanical properties of the osteotomized bone. These results suggest that dynamization degree and timing interactively affect the healing process. A combination of early dynamization with a moderate degree could enhance the ultimate biomechanical recovery of the fractured bone. [ABSTRACT FROM AUTHOR]

Lead halide perovskite CsPbX3 (X = Cl, Br, and I) nanocrystals (NCs) are widely used in the newest generation of lighting display equipment because of their excellent optical properties. However, their poor stability remains an urgent issue to overcome. Encapsulation has become a significant and effective strategy to promote the stability of perovskite NCs, particularly by the package coating of polymer and porous materials. Herein, a simple two-step encapsulation strategy is adopted to fabricate CsPbBrI2@zeolite/PMMA composite films to replace the previous preparation methods of perovskite films. A highly efficient and stable red-emitting material with great colour purity and excellent PLQY of ∼53.9% is manufactured by this simple and effective packaging method. Furthermore, because of the first-encapsulation with zeolite, the CsPbBrI2@zeoite/PMMA composite films not only reduced the agglomeration of NCs but also obtained better optical performance and environmental stability compared to that of pure CsPbBrI2/PMMA. Ultimately, WLEDs constructed by the red-emitting CsPbBrI2@zeolite/PMMA composite material achieve an outstanding colour rendering index, luminous efficiency and correlated color temperature (CRI = 94.5, LE = 77.22 lm W−1 and CCT = 5354 K), and realize tunable colour coordinates of (0.3359–0.32912, 0.3455–0.3336) in the white light area, implying that CsPbBrI2@zeolite/PMMA is very promising for obtaining a high CRI of WLEDs instead of traditional phosphor. The facile two-step encapsulation method proposed in this study provides a prospect for obtaining high-quality perovskites. [ABSTRACT FROM AUTHOR]

In this report, a mixed‐metal cation‐based halide perovskite (HP) CsPb1−xTixBr3 quantum dots (QDs) were first embedded in the B–Si–Zn glasses using a traditional approach of melt quenching and heat treating. A battery of test results such as photoluminescence, X‐ray diffraction, and time‐resolved attenuation prove that Ti ions do not destroy the properties of CsPbBr3, and they are successfully doped into CsPbBr3. At the same time, the doping of Ti ions also reduces the toxicity of lead. By altering the ratio of Pb/Ti, we determined the optimum ratio of CsPb0.7Ti0.3Br3 QDs through experimental data. Due to the excellent optical properties and stability of CsPb0.7Ti0.3Br3 QDs glass, it was designed to construct the white‐light emitting diode device with tunable color coordinate, color rendering index, correlated color temperature, and a high luminous efficiency compared with CsPbBr3 QDs glass, which may be a promising candidate for the field of lighting and displays. [ABSTRACT FROM AUTHOR]

All-inorganic cesium lead halide perovskite CsPb2Br5 nanocrystals (NCs) have attracted tremendous attention owing to their unique optoelectronic properties. However, their tolerance to atmospheric moisture is limited by their corresponding poor stability, which has drastically prevented the broad application of the materials in lasers, light-emitting diodes (LED) and, most recently, photocatalysis. To address this issue, we have successfully demonstrated the design and synthesis of a nanocomposite material, CsPb2Br5 NCs coated in mesoporous silica (NCs-MS), with high photoluminescence (PL) intensity, bright emission and enhanced water stability, thermal stability and photostability versus naked CsPb2Br5 NCs. The components and structure of the prepared CsPb2Br5 NCs-MS nanocomposite were investigated in detail by PL, XRD, TEM and HAADF-STEM studies. Furthermore, the mechanism behind the outstanding stability and optical properties of the prepared NCs-MS nanocomposite is discussed. Owing to the ultrahigh stability of the NCs-MS nanocomposite, the white LED (WLED) assembled by coating the CsPb2Br5 NCs-MS nanocomposite and commercial red CaAlSiN3:Eu2+ phosphor powder on an InGaN blue chip showed CIE chromaticity coordinates of (0.3377, 0.3309) and presented excellent optical parameters with a CRI of 82.9, a CCT of 5035 K and an LE of 64.9 lm W−1. This work provides a new pathway for the synthesis and application of all-inorganic cesium lead halide perovskite materials in WLEDs and display devices. [ABSTRACT FROM AUTHOR]

Long noncoding RNA KCNQ1OT1 participates in the regulation of imprinted genes within the kcnq1 domain. But its roles in carcinogenesis and metastasis remain largely elusive. Herein, we evaluated its potential in non‐small‐cell lung cancer (NSCLC) progression. We demonstrated that the KCNQ1OT1 level was upregulated in NSCLC tissues and cell lines. High KCNQ1OT1 level correlated with poor overall and progression‐free survival in NSCLC patients. KCNQ1OT1 facilitated proliferation, migration, and invasion in H460 cells. Furthermore, knockdown of KCNQ1OT1 reduced the expression of HSP90AA1. KCNQ1OT1 presented a positive correlation with HSP90AA1 which predicted the tumor progression in NSCLC from The Cancer Genome Atlas database. Intriguingly, KCNQ1OT1 modulated HSP90AA1 expression by sponging miR‐27b‐3p. MiR‐27b‐3p counteracted the effect of KCNQ1OT1 on HSP90AA1 expression, H460 cell migration, and invasion. These data revealed a role for KCNQ1OT1 as an oncogene through miR‐27b‐3p/HSP90AA1 axis during NSCLC progression. Long noncoding RNA KCNQ1OT1 promotes non‐small‐cell lung cancer progression. KCNQ1OT1 modulates HSP90AA1 expression by sponging miR‐27b‐3p. [ABSTRACT FROM AUTHOR]

Defects in cable joints, induced in the process of manufacturing or assembling, can alter the distribution of the electrical field seriously. To investigate the impacts of different defects on electrical field distribution in cable joints, equivalent models of 110 kV cable joints with needle damage, impurity defect and scratch in insulation are established, respectively. The distribution of electrical potential and field strength in cable joints with dissimilar defects is obtained by finite element analysis (FEA). The results indicate that the needle damage, among the three different defects, generates most excessive electrical field strength distortion surrounding the defect, even exceeding the breakdown strength of air. The results show that these defects can easily result in partial discharge (PD), which leads them to pay more attention to the operation of cable joints. [ABSTRACT FROM AUTHOR]