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102. Accuracy of Genomic Selection for Important Economic Traits of Cashmere and Meat Goats Assessed by Simulation Study

Author

Yan, Xiaochun, primary, Zhang, Tao, additional, Liu, Lichun, additional, Yu, Yongsheng, additional, Yang, Guang, additional, Han, Yaqian, additional, Gong, Gao, additional, Wang, Fenghong, additional, Zhang, Lei, additional, Liu, Hongfu, additional, Li, Wenze, additional, Yan, Xiaomin, additional, Mao, Haoyu, additional, Li, Yaming, additional, Du, Chen, additional, Li, Jinquan, additional, Zhang, Yanjun, additional, Wang, Ruijun, additional, Lv, Qi, additional, Wang, Zhixin, additional, Zhang, Jiaxin, additional, Liu, Zhihong, additional, Wang, Zhiying, additional, and Su, Rui, additional

Published
2022
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106. The new Haemaphysalis longicornis genome provides insights into its requisite biological traits

Author

Yu, Zhijun, primary, He, Biao, additional, Gong, Zhen, additional, Liu, Yan, additional, Wang, Qianghui, additional, Yan, Xiaomin, additional, Zhang, Tiantian, additional, Masoudi, Abolfazl, additional, Zhang, Xu, additional, Wang, Tianhong, additional, Yang, Xiaolong, additional, Wang, Hui, additional, Liu, Quan, additional, Liu, Jingze, additional, and Tu, Changchun, additional

Published
2022
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109. Significant histological disease of patients with chronic hepatitis B virus infection in the grey zone.

Author

Wang, Jian, Yan, Xiaomin, Zhu, Li, Liu, Jiacheng, Qiu, Yuanwang, Li, Yiguang, Liu, Yilin, Xue, Ruifei, Zhan, Jie, Jiang, Suling, Geng, Yu, Wan, Yawen, Li, Ming, Mao, Minxin, Gao, Dongmei, Yin, Shengxia, Tong, Xin, Xia, Juan, Ding, Weimao, and Chen, Yuxin

Subjects
*HEPATITIS B, *CHRONIC hepatitis B, *CHRONIC diseases, *HEPATIC fibrosis, *VIRUS diseases, *HEPATITIS
Abstract

Summary: Background: Many patients with chronic hepatitis B (CHB) do not meet the definitions of the traditional natural phases and are classified as being in the grey zone (GZ). Aims: To investigate liver histology, and to establish a management strategy for patients with CHB in the GZ. Methods: This study included 1043 patients with CHB who underwent liver biopsy. Phases of natural history were determined according to the AASLD 2018 hepatitis B guidance. CHB patients in the GZ were divided into HBeAg‐positive, normal ALT and HBV DNA ≤106 IU/ml (GZ‐A); HBeAg‐positive, elevated ALT and HBV DNA ≤2 × 104 IU/ml (GZ‐B); HBeAg‐negative, normal ALT and HBV DNA ≥2 × 103 IU/ml (GZ‐C) and HBeAg‐negative, elevated ALT and HBV DNA ≤2 × 103 IU/ml (GZ‐D). Significant histological disease was defined as liver inflammation ≥G2 and/or liver fibrosis ≥S2. Results: Two hundred and forty two (23.2%) patients were in the GZ. Approximately 72.7% had significant histological disease. HBeAg‐positive GZ CHB patients had a higher proportion of significant histological disease than HBeAg‐negative GZ patients (91.1% vs. 68.5%, p = 0.002). GZ‐D (42.6%) was the dominant category, followed by GZ‐C (38.8%), GZ‐A (10.3%) and GZ‐B (8.3%). The highest proportion of significant histological disease was observed patients in GZ‐B (100.0%), followed by GZ‐A (84.0%), GZ‐D (69.9%) and GZ‐C (67.0%). Prothrombin time (PT) was an independent risk factor of significant histological disease in the HBeAg‐negative GZ. Conclusions: Over 70% of GZ CHB patients had significant histological disease. We recommend antiviral treatment for HBeAg‐positive and HBeAg‐negative GZ CHB patients with high PT. [ABSTRACT FROM AUTHOR]

Published
2023
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110. Clinical features of chronic hepatitis B patients with lean nonalcoholic fatty liver disease.

Author

Wang, Jian, Liu, Jiacheng, Liu, Yilin, Xue, Ruifei, Zhan, Jie, Jiang, Suling, Wang, Li, Yan, Xiaomin, Xiong, Yali, Xia, Juan, Yin, Shengxia, Tong, Xin, Chen, Yuxin, Li, Jie, Huang, Rui, and Wu, Chao

Subjects
NON-alcoholic fatty liver disease, CHRONIC hepatitis B, HEPATITIS associated antigen, HEPATIC fibrosis, HEPATITIS B virus
Abstract

Background: The clinical features have been well described in obese chronic hepatitis B (CHB) patients with nonalcoholic fatty liver disease (NAFLD). However, little is known about the clinical features of lean CHB‐NAFLD patients. Methods: The study retrospectively included treatment‐naïve CHB patients who underwent ultrasound between 2015 and 2021. Liver fibrosis was assessed by aspartate aminotransferase (AST) to platelet ratio index (APRI), Fibrosis‐4 score (FIB‐4), NAFLD fibrosis score (NFS), and transient elastography. Results: Among 1226 CHB‐NAFLD patients, 25.0% patients were lean. The age, gender, and platelet, alanine aminotransferase, AST, and albumin levels were comparable between lean CHB‐NAFLD and nonlean patients. The levels of plasma glucose, triglycerides, total cholesterol, and uric acid, as well as proportions of concurrent hypertension and diabetes, were lower in lean patients. Lean patients presented higher hepatitis B surface antigen (HBsAg) levels (3.4 log10 IU/ml vs. 3.2 log10 IU/ml, p = 0.006), hepatitis B virus (HBV) DNA levels (4.1 log10 IU/ml vs. 3.2 log10 IU/ml, p < 0.001), and hepatitis B e antigen (HBeAg) positive proportions (40.4% vs. 30.2%, p = 0.002) than nonlean patients. The values of APRI, FIB‐4, and liver stiffness were comparable between two groups. However, lean patients had lower NFS values (−3.0 vs. −2.6, p < 0.001) and lower proportions (12.6% vs. 21.1%, p = 0.003) of advanced fibrosis (NFS ≥ −1.5) than nonlean patients. Similar results were observed in HBeAg‐positive and HBeAg‐negative subgroups. Conclusions: Nearly a quarter of CHB‐NAFLD patients were lean. Lean patients had lower proportions of metabolic abnormalities and advanced liver fibrosis than nonlean patients. However, lean CHB‐NAFLD patients had higher HBsAg levels, HBV DNA levels, and HBeAg‐positive proportions. Registry and registration no. of the study/trial: Clinicaltrials.gov, Identifier: NCT03097952. [ABSTRACT FROM AUTHOR]

Published
2023
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113. Direct carbon solid oxide fuel cells powered by rice husk biochar

Author

Cai, Weizi, primary, Tong, Xin, additional, Yan, Xiaomin, additional, Li, Hualing, additional, Li, Yuzhi, additional, Gao, Xinyu, additional, Guo, Yanning, additional, Wu, Weichuang, additional, Fu, Daishuang, additional, Huang, Xingkai, additional, Liu, Jiang, additional, and Wang, Hailin, additional

Published
2021
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114. Presence of Liver Inflammation in Asian Patients With Chronic Hepatitis B With Normal ALT and Detectable HBV DNA in Absence of Liver Fibrosis

Author

Liu, Jiacheng, primary, Wang, Jian, additional, Yan, Xiaomin, additional, Xue, Ruifei, additional, Zhan, Jie, additional, Jiang, Suling, additional, Geng, Yu, additional, Liu, Yilin, additional, Mao, Minxin, additional, Xia, Juan, additional, Yin, Shengxia, additional, Tong, Xin, additional, Chen, Yuxin, additional, Ding, Weimao, additional, Huang, Rui, additional, and Wu, Chao, additional

Published
2021
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118. Integrin β2 and β3: Two plasmatocyte markers deepen our understanding of the development of plasmatocytes in the silkworm Bombyx mori.

Author

Zhang, Kui, Su, Jingjing, Hu, Xin, Yan, Xiaomin, Chen, Siyuan, Li, Chongyang, Pan, Guangzhao, Chang, Hongbo, Tian, Wenli, Abbas, Muhammad Nadeem, and Cui, Hongjuan

Subjects
SILKWORMS, HEMATOPOIETIC system, CELLULAR signal transduction, HEMOLYMPH, HEMATOPOIESIS, BLOOD cells
Abstract

Insect hemocytes play important biological roles at developmental stages, metamorphosis, and innate immunity. As one of the most abundant cell types, plasmatocytes can participate in various innate immune responses, especially in encapsulation and node formation. Here, 2 molecular markers of plasmatocytes, consisting of integrin β2 and β3, were identified and used to understand the development of plasmatocytes. Plasmatocytes are widely distributed in the hematopoietic system, including circulating hemolymph and hematopoietic organs (HPOs). HPOs constantly release plasmatocytes with high proliferative activity in vitro; removal of HPOs leads to a dramatic reduction in the circulating plasmatocytes, and the remaining plasmatocytes gradually lose their ability to proliferate in vivo. Our results demonstrated that the release of plasmatocytes from HPOs is regulated by insulin‐mediated signals and their downstream pathways, including PI3K/Akt and MAPK/Erk signals. The insulin/PI3K/Akt signaling pathway can significantly irritate the hematopoiesis, and its inhibitor LY294002 could inhibit the hemocytes discharged from HPOs. While the insulin/MAPK/Erk signaling pathway plays a negative regulatory role, inhibiting its activity with U0126 can markedly promote the discharge of plasmatocytes from HPOs. Our results indicate that the circulating plasmatocytes are mainly generated and discharged by HPOs. This process is co‐regulated by the PI3K/Akt and MAPK/Erk signals in an antagonistic manner to adjust the dynamic balance of the hemocytes. These findings can enhance our understanding of insect hematopoiesis. [ABSTRACT FROM AUTHOR]

Published
2022
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119. Association of anti‐HBc and liver inflammation in HBeAg‐negative chronic hepatitis B virus‐infected patients with normal ALT and detectable HBV DNA

Author

Yao, Kefang, primary, Wang, Jian, additional, Wang, Lijuan, additional, Xia, Juan, additional, Yan, Xiaomin, additional, Wu, Weihua, additional, Liu, Jiacheng, additional, Wang, Li, additional, Yin, Shengxia, additional, Tong, Xin, additional, Ding, Weimao, additional, Huang, Rui, additional, and Wu, Chao, additional

Published
2021
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120. Gamma-glutamyl Transpeptidase to Platelet Ratio Predicts Liver Injury in Hepatitis B e Antigen-negative Chronic Hepatitis B Patients With Normal Alanine Aminotransferase

Author

Zhao, Xiang-An, primary, Wang, Jian, additional, Wei, Jie, additional, Liu, Jiacheng, additional, Chen, Guangmei, additional, Wang, Li, additional, Wang, Guiyang, additional, Xia, Juan, additional, Wu, Weihua, additional, Yin, Shengxia, additional, Tong, Xin, additional, Yan, Xiaomin, additional, Ding, Weimao, additional, Xiang, Xiaoxing, additional, Huang, Rui, additional, and Wu, Chao, additional

Published
2021
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122. Additional file 1 of Clinical and virological course of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center cohort study

Author

Huang, Rui, Zhu, Li, Xue, Leyang, Yan, Xuebing, Wang, Jian, Huang, Songping, Zhang, Biao, Xu, Tianmin, Ji, Fang, Li, Chunyang, Ming, Fang, Zhao, Yun, Li, Yang, Cheng, Juan, Wang, Yinling, Shao, Huaping, Hong, Shuqin, Chen, Kang, Zhao, Xiang-an, Sang, Dawen, Zou, Lei, Zhao, Haiyan, Guan, Xinying, Chen, Xiaobing, Xu, Biyun, Xia, Juan, Chen, Yuxin, Yan, Xiaomin, Wei, Jie, Liu, Jiacheng, Liu, Longgen, Zhu, Chuanwu, and Wu, Chao

Abstract

Additional file 1 Fig. S1 The cumulative clearance of SARS-CoV-2 in different age and treatment groups using date of hospital admission as the start of follow up. Table S1. Cox regression analysis of factors for the clearance of SARS-CoV-2 using date of hospital admission as the start of follow-up. Table S2. Clinical characteristics of COVID-19 patients treated with interferon and without interferon.

Published
2021
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126. Additional file 4 of Alternative splicing during fruit development among fleshy fruits

Author

Yan, Xiaomin, Bai, Dan, Song, Hongtao, Lin, Kui, and Pang, Erli

Subjects
humanities
Abstract

Additional file 4: Fig. S3. Pipeline of the construction of high-quality transcriptomes. Transcripts poorly supported by spliced junctions, transcripts with low abundance, antisense transcripts, transcripts from unknown genes and single exon transcripts not found in the reference were removed. a cucumber. b melon. c papaya. d peach.

Published
2021
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127. Additional file 8 of Alternative splicing during fruit development among fleshy fruits

Author

Yan, Xiaomin, Bai, Dan, Song, Hongtao, Lin, Kui, and Pang, Erli

Abstract

Additional file 8: Fig. S6 Relationship between the genic features and the alternative splicing (AS). a Comparison of the length of introns between retained introns and other introns. b Correlations between the number of exons and the ratio of ES genes. c Correlations between the number of introns and the ratio of IR genes.

Published
2021
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130. Viral Metagenome-Based Precision Surveillance of Pig Population at Large Scale Reveals Viromic Signatures of Sample Types and Influence of Farming Management on Pig Virome

Author

He, Biao, primary, Gong, Wenjie, additional, Yan, Xiaomin, additional, Zhao, Zihan, additional, Yang, Ling’en, additional, Tan, Zhizhou, additional, Xu, Lin, additional, Zhu, Aiwei, additional, Zhang, Jianing, additional, Rao, Jihong, additional, Yu, Xinglong, additional, Jiang, Jianfeng, additional, Lu, Zongji, additional, Zhang, Yifang, additional, Wu, Jianmin, additional, Li, Yong, additional, Shi, Yuxiang, additional, Jiang, Qing, additional, Chen, Xiwen, additional, and Tu, Changchun, additional

Published
2021
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132. Clinical features of COVID‐19 patients with non‐alcoholic fatty liver disease

Author

Huang, Rui, Zhu, Li, Wang, Jian, Xue, Leyang, Liu, Longgen, Yan, Xuebing, Huang, Songping, Li, Yang, Yan, Xiaomin, Zhang, Biao, Xu, Tianmin, Li, Chunyang, Ji, Fang, Ming, Fang, Zhao, Yun, Cheng, Juan, Wang, Yinling, Zhao, Haiyan, Hong, Shuqin, Chen, Kang, Zhao, Xiang‐an, Zou, Lei, Sang, Dawen, Shao, Huaping, Guan, Xinying, Chen, Xiaobing, Chen, Yuxin, Wei, Jie, Zhu, Chuanwu, and Wu, Chao

Subjects
Coronavirus disease 2019, Non‐alcoholic fatty liver disease, Original Article, Clinical features, Original Articles, Liver injury, digestive system diseases
Abstract

Background and Aims Previous studies reported that coronavirus disease 2019 (COVID‐19) was likely to result in liver injury. However, few studies investigated liver injury in COVID‐19 patients with chronic liver diseases. We described the clinical features in COVID‐19 patients with non‐alcoholic fatty liver disease (NAFLD). Methods Confirmed COVID‐19 patients from hospitals in 10 cities of Jiangsu province, China were retrospectively included between January 18, 2020, and February 26, 2020. Hepatic Steatosis Index (HSI) was used to defined NAFLD. Results A total of 280 COVID‐19 patients were enrolled. Eighty‐six (30.7%) of 280 COVID‐19 patients were diagnosed as NAFLD by HSI. 100 (35.7%) patients presented abnormal liver function on admission. The median ALT levels (34.5 U/L vs. 23.0 U/L, P40 U/L) (40.7% vs. 10.8%, P

Published
2020

138. Presence of Liver Inflammation in Asian Patients With Chronic Hepatitis B With Normal ALT and Detectable HBV DNA in Absence of Liver Fibrosis.

Author

Liu, Jiacheng, Wang, Jian, Yan, Xiaomin, Xue, Ruifei, Zhan, Jie, Jiang, Suling, Geng, Yu, Liu, Yilin, Mao, Minxin, Xia, Juan, Yin, Shengxia, Tong, Xin, Chen, Yuxin, Ding, Weimao, Huang, Rui, and Wu, Chao

Subjects
HEPATIC fibrosis, HEPATITIS, SEROCONVERSION, CHRONIC hepatitis B, ASIANS, HEPATITIS B virus, DNA
Abstract

Liver biopsies are recommended to exclude significant liver inflammation in patients with chronic hepatitis B (CHB) with elevated HBV DNA but without other indications for antiviral treatment. We aimed to investigate the proportions and determinants of significant inflammation in Asian patients with CHB with detectable HBV DNA. We conducted a cross‐sectional study that retrospectively included 581 patients with CHB with detectable HBV DNA who had undergone liver biopsy. Liver inflammation and fibrosis were staged by Scheuer's classification. Significant inflammation and significant fibrosis were defined as G ≥ 2 and S ≥ 2, respectively. There were 179 (30.8%) patients with alanine aminotransferase (ALT) < 1 × upper limit of normal (ULN), 205 (35.3%) patients with ALT 1‐2 × ULN, and 197 (33.9%) patients with ALT > 2 × ULN. A total of 397 (68.3%) patients had significant inflammation, and 340 (58.5%) patients had significant fibrosis. Significant inflammation was found in 85% of patients with significant fibrosis and in 44.8% of patients without significant fibrosis. Furthermore, 28.7% of patients with CHB with detectable HBV DNA and normal ALT in the absence of significant fibrosis had significant inflammation. Moderate HBV DNA (5‐7 log10 IU/mL) was a risk factor for significant inflammation (odds ratio [OR] 6.929, 95% confidence interval [CI] 2.830‐16.966, P < 0.001) in patients with CHB with detectable HBV DNA, especially for patients with detectable HBV DNA and normal ALT in the absence of significant fibrosis (adjusted OR 13.161, 95% CI 1.026‐168.889, P = 0.048). Conclusion: A high proportion of CHB patients with detectable HBV DNA and normal ALT in the absence of significant fibrosis have significant liver inflammation. Liver biopsies are recommended to evaluate liver inflammation in such patients, especially for those with moderate HBV DNA. [ABSTRACT FROM AUTHOR]

Published
2022
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139. Risk factors of liver injury in patients with coronavirus disease 2019 in Jiangsu, China: A retrospective, multi‐center study

Author

Wang, Jian, primary, Zhu, Li, additional, Xue, Leyang, additional, Liu, Longgen, additional, Yan, Xuebing, additional, Yan, Xiaomin, additional, Huang, Songping, additional, Zhang, Biao, additional, Xu, Tianmin, additional, Li, Chunyang, additional, Ji, Fang, additional, Ming, Fang, additional, Zhao, Yun, additional, Cheng, Juan, additional, Shao, Huaping, additional, Chen, Kang, additional, Zhao, Xiang‐an, additional, Sang, Dawen, additional, Zhao, Haiyan, additional, Guan, Xinying, additional, Chen, Xiaobing, additional, Chen, Yuxin, additional, Liu, Jiacheng, additional, Huang, Rui, additional, Zhu, Chuanwu, additional, and Wu, Chao, additional

Published
2020
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140. Sulfur-tolerant Fe-doped La0·3Sr0·7TiO3 perovskite as anode of direct carbon solid oxide fuel cells

Author

Cai, Weizi, primary, Cao, Dan, additional, Zhou, Mingyang, additional, Yan, Xiaomin, additional, Li, Yuzhi, additional, Wu, Zhen, additional, Lü, Shengping, additional, Mao, Caiyun, additional, Xie, Yongmin, additional, Zhao, Caiwen, additional, Yu, Jialing, additional, Ni, Meng, additional, Liu, Jiang, additional, and Wang, Hailin, additional

Published
2020
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141. Liver Inflammation and Fibrosis of HBeAg-Negative Patients in the Grey Zone

Author

Yao, Renling, primary, Wang, Jian, additional, Wei, Jie, additional, Yan, Xiaomin, additional, Chen, Yuxin, additional, Xia, Juan, additional, Yang, Yue, additional, Yao, Kefang, additional, Wu, Weihua, additional, Liu, Yong, additional, Liu, Jiacheng, additional, Zhang, Zhaoping, additional, Ding, Weimao, additional, Huang, Rui, additional, and Wu, Chao, additional

Published
2020
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142. Temporal association between carbapenems usage and antimicrobial resistance in gram-negative bacteria at a tertiary hospital in Nanjing, China

Author

Hao, Yingying, primary, Chen, Shixing, additional, Chang, Haiyan, additional, Yan, Xiaomin, additional, Zhou, Wanqing, additional, Cao, Xiaoli, additional, Huang, Rui, additional, Zhang, Zhaoping, additional, Zhang, Haixia, additional, Jia, Bei, additional, Wu, Weihua, additional, Xiong, Yali, additional, Chen, Yuxin, additional, and Wu, Chao, additional

Published
2020
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143. Clinical Features of Patients With COVID‐19 With Nonalcoholic Fatty Liver Disease

Author

Huang, Rui, primary, Zhu, Li, additional, Wang, Jian, additional, Xue, Leyang, additional, Liu, Longgen, additional, Yan, Xuebing, additional, Huang, Songping, additional, Li, Yang, additional, Yan, Xiaomin, additional, Zhang, Biao, additional, Xu, Tianmin, additional, Li, Chunyang, additional, Ji, Fang, additional, Ming, Fang, additional, Zhao, Yun, additional, Cheng, Juan, additional, Wang, Yinling, additional, Zhao, Haiyan, additional, Hong, Shuqin, additional, Chen, Kang, additional, Zhao, Xiang‐an, additional, Zou, Lei, additional, Sang, Dawen, additional, Shao, Huaping, additional, Guan, Xinying, additional, Chen, Xiaobing, additional, Chen, Yuxin, additional, Wei, Jie, additional, Zhu, Chuanwu, additional, and Wu, Chao, additional

Published
2020
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147. Ni-doped A-site-deficient La0.7Sr0.3Cr0.5Mn0.5O3-δ perovskite as anode of direct carbon solid oxide fuel cells

Author

Cai, Weizi, primary, Zhou, Mingyang, additional, Cao, Dan, additional, Yan, Xiaomin, additional, Li, Qing, additional, Lü, Shengping, additional, Mao, Caiyun, additional, Li, Yuzhi, additional, Xie, Yongmin, additional, Zhao, Caiwen, additional, Yu, Jialing, additional, Ni, Meng, additional, Liu, Jiang, additional, and Wang, Hailin, additional

Published
2020
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148. A case series of COVID‐19 patients with chronic hepatitis B virus infection

Author

Li, Yang, primary, Li, Chunyang, additional, Wang, Jian, additional, Zhu, Chuanwu, additional, Zhu, Li, additional, Ji, Fang, additional, Liu, Longgen, additional, Xu, Tianmin, additional, Zhang, Biao, additional, Xue, Leyang, additional, Yan, Xiaomin, additional, Huang, Rui, additional, Wu, Chao, additional, and Yan, Xuebing, additional

Published
2020
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