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101. Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS)

Author

Yang, Limin, primary, Sato, Miori, additional, Saito-Abe, Mayako, additional, Irahara, Makoto, additional, Nishizato, Minaho, additional, Sasaki, Hatoko, additional, Konishi, Mizuho, additional, Ishitsuka, Kazue, additional, Mezawa, Hidetoshi, additional, Yamamoto-Hanada, Kiwako, additional, Matsumoto, Kenji, additional, Ohya, Yukihiro, additional, Kamijima, Michihiro, additional, Yamazaki, Shin, additional, Kishi, Reiko, additional, Yaegashi, Nobuo, additional, Hashimoto, Koichi, additional, Mori, Chisato, additional, Ito, Shuichi, additional, Yamagata, Zentaro, additional, Inadera, Hidekuni, additional, Nakayama, Takeo, additional, Iso, Hiroyasu, additional, Shima, Masayuki, additional, Kurozawa, Youichi, additional, Suganuma, Narufumi, additional, Kusuhara, Koichi, additional, and Katoh, Takahiko, additional

Published
2021
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105. Skin care interventions in infants for preventing eczema and food allergy: a Cochrane systematic review and individual participant data meta?analysis

Author

Kelleher, Maeve M., Cro, Suzie, Van Vogt, Eleanor, Cornelius, Victoria, Lodrup Carlsen, Karin C., Rehbinder, Eva Maria, Lowe, Adrian, Dissanayake, Eishika, Shimojo, Naoki, Yonezawa, Kaori, Ohya, Yukihiro, Yamamoto?Hanada, Kiwako, Morita, Kumiko, Cork, Michael, Cooke, Alison, Simpson, Eric L., McClanahan, Danielle, Weidinger, Stephan, Schmitt, Jochen, Axon, Emma, Tran, Lien, Surber, Christian, Askie, Lisa M., Duley, Lelia, Chalmers, Joanne R., Williams, Hywel C., and Boyle, Robert J.

Subjects
Immunology, Immunology and Allergy
Published
2021

106. Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children's Study.

Author

Yang, Limin, Sato, Miori, Saito-Abe, Mayako, Miyaji, Yumiko, Shimada, Mami, Sato, Chikako, Nishizato, Minaho, Kumasaka, Natsuhiko, Mezawa, Hidetoshi, Yamamoto-Hanada, Kiwako, and Ohya, Yukihiro

Abstract

Previous epidemiological studies have reported an increased risk of anemia in people with allergic disorders. However, previous studies have followed a cross-sectional design. The aim of this study was to investigate the association between the two conditions with a cohort dataset. We used data of 80,943 children in the Japan Environment and Children's Study, the largest birth cohort in Japan. The association between anemia and allergic disorders was evaluated with a logistic regression model and propensity score analysis. After adjusting for potential confounders, children with asthma (odds ratio [OR], 1.85; 95% confidence interval [CI], 1.32–2.60), atopic dermatitis (OR, 2.18; 95% CI, 1.66–2.85), allergic rhinitis (OR, 1.35; 95% CI, 1.05–1.74), allergic rhinoconjunctivitis (OR, 2.95; 95% CI, 1.91–4.54), and food allergies (OR, 1.92; 95% CI, 1.44–2.56) at 2 years of age predicted high odds of developing anemia in the next year. Any allergy at 2 years of age was associated with an increased risk of anemia at the age of 3 years (OR, 1.80; 95% CI, 1.41–2.29). The findings remained stable in the propensity score analysis. Results suggest that allergic diseases were related to caregiver-reported anemia in children. [ABSTRACT FROM AUTHOR]

Published
2022
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107. How a Family History of Allergic Diseases Influences Food Allergy in Children: The Japan Environment and Children's Study.

Author

Saito-Abe, Mayako, Yamamoto-Hanada, Kiwako, Pak, Kyongsun, Iwamoto, Shintaro, Sato, Miori, Miyaji, Yumiko, Mezawa, Hidetoshi, Nishizato, Minaho, Yang, Limin, Kumasaka, Natsuhiko, Kobayashi, Tohru, and Ohya, Yukihiro

Abstract

The influence of family allergic history on food allergy in offspring in Japan is unknown. We analyzed data from a nationwide birth cohort study using logistic regression models to examine the associations of maternal, paternal, and both parental histories of allergic diseases (food allergy, atopic dermatitis, asthma, and rhinitis) with their child's food allergy at 1.5 and 3 years of age. This analysis included 69,379 singleton full-term mothers and 37,179 fathers and their children. All parental histories of allergic diseases showed significant positive associations with their child's food allergy. When both parents had a history of allergic diseases, the adjusted odds ratio (aOR) tended to be higher than when either parent had allergic diseases (p for trend < 0.0001). The highest aOR was detected when both parents had food allergy (2.60; 95% confidential interval, 1.58–4.27), and the aOR was 1.71 when either parent had food allergy (95% confidential interval, 1.54–1.91). The aORs were attenuated but still had significant positive associations after adjusting for the child's atopic dermatitis, a risk factor for allergy development. In conclusion, all parental allergic diseases were significantly positively associated with their child's food allergy. The effect of family history showed a stepwise increase in risk from either parent to both parents, and the highest risk of allergic disease was a parental history of food allergy. [ABSTRACT FROM AUTHOR]

Published
2022
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109. CQ2 Is oral immunotherapy more efficient than a conventional elimination diet in patients with IgE-dependent cow's milk allergy?

Author

Kawamoto, Norio, primary, Fusayasu, Naoko, additional, Sato, Koichiro, additional, Miura, Taro, additional, Suzuki, Shuichi, additional, Nakamura, Toshinori, additional, Yamamoto-Hanada, Kiwako, additional, Futamura, Masaki, additional, Okafuji, Ikuo, additional, Yamada, Yoshiyuki, additional, and Ebisawa, Motohiro, additional

Published
2021
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113. Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy? A systematic review

Author

Murai, Hiroki, Irahara, Makoto, Sugimoto, Mayumi, Takaoka, Yuri, Takahashi, Kyohei, Wada, Takuya, Yamamoto-Hanada, Kiwako, Okafuji, Ikuo, Yamada, Yoshiyuki, Futamura, Masaki, Ebisawa, Motohiro, Murai, Hiroki, Irahara, Makoto, Sugimoto, Mayumi, Takaoka, Yuri, Takahashi, Kyohei, Wada, Takuya, Yamamoto-Hanada, Kiwako, Okafuji, Ikuo, Yamada, Yoshiyuki, Futamura, Masaki, and Ebisawa, Motohiro

Abstract

Background: IgE-mediated egg allergy is a common food allergy worldwide. Patients with egg allergy are known to easily achieve tolerance compared to other allergens such as nuts. Oral food challenge (OFC) is often performed on patients diagnosed with or suspected of having IgE-mediated food allergy, but whether hen's egg OFC is useful in IgE-dependent egg allergy patients to avoid complete elimination remains unknown. Methods: We identified articles in which OFCs were performed in Japanese patients diagnosed with or suspected of having IgE-mediated egg allergy. We evaluated whether the OFCs were useful to avoid the complete elimination of eggs by assessing the following: (1) the number of patients who could avoid complete elimination; (2) the number of patients who experienced serious adverse events (SAEs); or (3) adverse events (AEs); (4) improvement in quality of life (QOL); and (5) immunological changes. Results: Fifty-nine articles were selected in the study; all the references were case series or case studies in which OFC was compared to pre-challenge conditions. The overall negative ratio against egg OFC was 62.7%, but an additional 71.9% of OFC-positive patients could take eggs when expanded to partial elimination. Of the 4182 cases, 1146 showed AEs in the OFC, and two cases reached an SAE. Two reports showed an improvement in QOL and immunological changes, although the evidence was weak. Conclusions: OFCs against eggs may be useful to avoid complete elimination, but medical professionals should proceed with the test safely and carefully.

Published
2021

118. Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study

Author

Kiguchi, Tomoyuki, primary, Yamamoto-Hanada, Kiwako, additional, Saito-Abe, Mayako, additional, Sato, Miori, additional, Irahara, Makoto, additional, Ogita, Hiroya, additional, Miyagi, Yoshitsune, additional, Inuzuka, Yusuke, additional, Toyokuni, Kenji, additional, Nishimura, Koji, additional, Ishikawa, Fumi, additional, Miyaji, Yumiko, additional, Kabashima, Shigenori, additional, Fukuie, Tatsuki, additional, Narita, Masami, additional, and Ohya, Yukihiro, additional

Published
2021
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120. Additional file 3 of Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

Author

Yamamoto-Hanada, Kiwako, Kyongsun Pak, Saito-Abe, Mayako, Limin Yang, Miori Sato, Mezawa, Hidetoshi, Hatoko Sasaki, Minaho Nishizato, Konishi, Mizuho, Ishitsuka, Kazue, Matsumoto, Kenji, Saito, Hirohisa, and Ohya, Yukihiro

Abstract

Additional file 3: Table S1. Summary of participant baseline characteristics. All data are presented as numbers (percentages). CQ: clinical question. Table S2. Summary of initial live vaccines and inactivated vaccines, RQ1. Table S3. Summary of the number of initial inactivated vaccines, RQ2. Table S4. Summary of number of initial BCG-only and rotavirus-only vaccines, RQ3

Published
2020
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122. Skincare interventions in infants for preventing eczema and food allergy: A cochrane systematic review and individual participant data meta‐analysis

Author

Kelleher, Maeve M., primary, Cro, Suzie, additional, Van Vogt, Eleanor, additional, Cornelius, Victoria, additional, Lodrup Carlsen, Karin C., additional, Ove Skjerven, Håvard, additional, Rehbinder, Eva Maria, additional, Lowe, Adrian, additional, Dissanayake, Eishika, additional, Shimojo, Naoki, additional, Yonezawa, Kaori, additional, Ohya, Yukihiro, additional, Yamamoto‐Hanada, Kiwako, additional, Morita, Kumiko, additional, Cork, Michael, additional, Cooke, Alison, additional, Simpson, Eric L., additional, McClanahan, Danielle, additional, Weidinger, Stephan, additional, Schmitt, Jochen, additional, Axon, Emma, additional, Tran, Lien, additional, Surber, Christian, additional, Askie, Lisa M., additional, Duley, Lelia, additional, Chalmers, Joanne R., additional, Williams, Hywel C., additional, and Boyle, Robert J., additional

Published
2021
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124. Skin care interventions in infants for preventing eczema and food allergy

Author

Kelleher, Maeve M, additional, Cro, Suzie, additional, Cornelius, Victoria, additional, Lodrup Carlsen, Karin C, additional, Skjerven, Håvard O, additional, Rehbinder, Eva M, additional, Lowe, Adrian J, additional, Dissanayake, Eishika, additional, Shimojo, Naoki, additional, Yonezawa, Kaori, additional, Ohya, Yukihiro, additional, Yamamoto-Hanada, Kiwako, additional, Morita, Kumiko, additional, Axon, Emma, additional, Surber, Christian, additional, Cork, Michael, additional, Cooke, Alison, additional, Tran, Lien, additional, Van Vogt, Eleanor, additional, Schmitt, Jochen, additional, Weidinger, Stephan, additional, McClanahan, Danielle, additional, Simpson, Eric, additional, Duley, Lelia, additional, Askie, Lisa M, additional, Chalmers, Joanne R, additional, Williams, Hywel C, additional, and Boyle, Robert J, additional

Published
2021
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126. Avoidance of Hen's Egg Based on IgE Levels Should Be Avoided for Children With Hen's Egg Allergy

Author

Miyagi, Yoshitsune, primary, Yamamoto-Hanada, Kiwako, additional, Ogita, Hiroya, additional, Kiguchi, Tomoyuki, additional, Inuzuka, Yusuke, additional, Toyokuni, Kenji, additional, Nishimura, Koji, additional, Irahara, Makoto, additional, Ishikawa, Fumi, additional, Sato, Miori, additional, Saito-Abe, Mayako, additional, Miyaji, Yumiko, additional, Kabashima, Shigenori, additional, Fukuie, Tatsuki, additional, Nomura, Ichiro, additional, and Ohya, Yukihiro, additional

Published
2021
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127. Executive summary: Japanese pediatric guideline for the treatment and management of asthma (JPGL) 2020

Author

Adachi, Yuichi, Takizawa, Takumi, Futamura, Masaki, Fujisawa, Takao, Yoshihara, Shigemi, members, Committee, Adachi, Yuichi, Takizawa, Takumi, Futamura, Masaki, Fujisawa, Takao, Yoshihara, Shigemi, Shimojo, Naoki, Iino, Akira, Ebisawa, Mothiro, Mochizuki, Hiroyuki, Ohya, Yukihiro, Katsunuma, Toshio, Kameda, Makoto, Inoue, Toshishige, Fukuie, Tatsuki, members, External committee, Iwanaga, Takashi, Kuriyama, Mariko, Kuroki, Haruo, Sonobe, Mariko, Takase, Masato, Masuko, Ikuyo, Collaborators, Yamaide, Fumiya, Yoshida, Koichi, Nagakura, Kenichi, Hirai, Kota, Miyaji, Yumiko, Ito, Yasunori, Yagi, Hisako, Miura, Katsushi, Horino, Satoshi, Fukuda, Hironobu, Yoshida, Yukinori, Takahashi, Shinichi, Natsume, Osamu, Nagao, Mizuho, Yamada, Yoshiyuki, team, Members of systematic review, Okafuji, Ikuo, Yamamoto-Hanada, Kiwako, Nakajima, Yoichi, Tanaka, Yuya, Suzuki, Shuichi, Sato, Kotaro, Murai, Hiroki, Miura, Taro, Hiraguchi, Yukiko, Takaoka, Yuri, Manabe, Tetsuharu, Kuwabara, Yu, Akashi, Kenichi, Nishikido, Tomoki, Sugimoto, Mayumi, Maeda, Mayu, Kawamoto, Norio, Takahashi, Kyohei, Yamaide, Akiko, Wada, Takuya, Kitazawa, Hiroshi, Saito, Mayako, Adviser, Executive, and Nishima, Sankei

Abstract

This article covers the salient and updated themes of the Japanese Pediatric Guidelines for the Treatment and Management of Asthma (JPGL) 2020 published by the Japanese Society of Pediatric Allergy and Clinical Immunology. In the 2020 guidelines, five new clinical questions (CQs) have been added to address the 12 CQs regarding the treatment of childhood asthma. “Infant and preschool asthma” is diagnosed when young children (<6 years of age) have three or more episodes of clear expiratory wheezing, which continue for more than 24 h, and symptom improvement can be observed after beta-2 agonist inhalation. In children without clear improvement, diagnostic therapeutic trial for the duration of 1 month with controller treatment can be used. Since long-term management is initiated, the treatment level is adjusted based on the current control status and the management of risk factors, with the provision for holistic care. This underscores the smooth transition of pediatric patients into adult services. There are several differences between the JPGL and the guidelines of other countries. Further evidence is obtained as the utility of the newly proposed management plans should be evaluated in the Japanese population.

Published
2022
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128. Associations of frequent emollient use with wheeze and asthma in young Japanese children: A survey of well‐child visits.

Author

Yamamoto‐Hanada, Kiwako, Pak, Kyongsun, Sato, Miori, Kram, Yuri Endo, Takemura, Yutaka, Inoue, Norihiro, and Ohya, Yukihiro

Subjects
*WHEEZE, *JAPANESE people, *ASTHMA, *IMMUNOGLOBULIN E, *ATOPIC dermatitis
Abstract

Keywords: asthma; emollients; skin barrier; well-child visit; wheeze EN asthma emollients skin barrier well-child visit wheeze 451 455 5 02/24/22 20220301 NES 220301 Key Messages We surveyed emollient use and wheeze and asthma in the children of well-child visits in Osaka and Tokyo, Japan. Our study indicated that the application of emollients on the skin did not affect wheezing but increased asthma events in young children at 3 years of age from a cross-sectional study of well-child visits. Associations of frequent emollient use with wheeze and asthma in young Japanese children: A survey of well-child visits. [Extracted from the article]

Published
2022
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130. Egg antigen was more abundant than mite antigen in children's bedding: Findings of the pilot study of the Japan Environment and Children's Study (JECS)

Author

Kitazawa, Hiroshi, Yamamoto-Hanada, Kiwako, Saito-Abe, Mayako, Ayabe, Tadayuki, Mezawa, Hidetoshi, Ishitsuka, Kazue, Konishi, Mizuho, Nakayama, Shoji F., Michikawa, Takehiro, Senju, Ayako, Tsuji, Mayumi, Kusuhara, Koichi, Sanefuji, Masafumi, Ohga, Shouichi, Oda, Masako, Mitsubuchi, Hiroshi, Katoh, Takahiko, Ikegami, Akihiko, Mise, Natan, Matsumoto, Kenji, Saito, Hirohisa, and Ohya, Yukihiro

Published
2019
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131. Allergy and immunology in young children of Japan: The JECS cohort

Author

Yamamoto-Hanada, Kiwako, primary, Pak, Kyongsun, additional, Saito-Abe, Mayako, additional, Yang, Limin, additional, Sato, Miori, additional, Irahara, Makoto, additional, Mezawa, Hidetoshi, additional, Sasaki, Hatoko, additional, Nishizato, Minaho, additional, Ishitsuka, Kazue, additional, Ohya, Yukihiro, additional, Kamijima, Michihiro, additional, Yamazaki, Shin, additional, Kishi, Reiko, additional, Yaegashi, Nobuo, additional, Hashimoto, Koichi, additional, Mori, Chisato, additional, Ito, Shuichi, additional, Yamagata, Zentaro, additional, Inadera, Hidekuni, additional, Nakayama, Takeo, additional, Iso, Hiroyasu, additional, Shima, Masayuki, additional, Kurozawa, Youichi, additional, Suganuma, Narufumi, additional, Kusuhara, Koichi, additional, and Katoh, Takahiko, additional

Published
2020
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133. Association between blood lead exposure and mental health in pregnant women: Results from the Japan environment and children’s study

Author

Ishitsuka, Kazue, primary, Yamamoto-Hanada, Kiwako, additional, Yang, Limin, additional, Mezawa, Hidetoshi, additional, Konishi, Mizuho, additional, Saito-Abe, Mayako, additional, Sasaki, Hatoko, additional, Nishizato, Minaho, additional, Sato, Miori, additional, Koeda, Tatsuya, additional, and Ohya, Yukihiro, additional

Published
2020
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135. Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: A prospective birth cohort study in Tokyo

Author

Irahara, Makoto, primary, Yamamoto-Hanada, Kiwako, additional, Yang, Limin, additional, Saito-Abe, Mayako, additional, Sato, Miori, additional, Inuzuka, Yusuke, additional, Toyokuni, Kenji, additional, Nishimura, Koji, additional, Ishikawa, Fumi, additional, Miyaji, Yumiko, additional, Fukuie, Tatsuki, additional, Narita, Masami, additional, and Ohya, Yukihiro, additional

Published
2020
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136. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study

Author

Yamamoto-Hanada, Kiwako, primary, Kawakami, Eiryo, additional, Saito-Abe, Mayako, additional, Sato, Miori, additional, Mitsubuchi, Hiroshi, additional, Oda, Masako, additional, Katoh, Takahiko, additional, Sanefuji, Masafumi, additional, Ohga, Shouichi, additional, Kuwajima, Mari, additional, Mise, Nathan, additional, Ikegami, Akihiko, additional, Kayama, Fujio, additional, Senju, Ayako, additional, Shimono, Masayuki, additional, Kusuhara, Koichi, additional, Yamazaki, Shin, additional, Nakayama, Shoji F., additional, Matsumoto, Kenji, additional, Saito, Hirohisa, additional, and Ohya, Yukihiro, additional

Published
2020
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138. Skincare interventions in infants for preventing eczema and food allergy

Author

Kelleher, Maeve M, primary, Cro, Suzie, additional, Cornelius, Victoria, additional, Axon, Emma, additional, Lodrup Carlsen, Karin C, additional, Skjerven, Håvard Ove, additional, Rehbinder, Eva Maria, additional, Lowe, Adrian, additional, Dissanayake, Eishika, additional, Shimojo, Naoki, additional, Yonezawa, Kaori, additional, Ohya, Yukihiro, additional, Yamamoto-Hanada, Kiwako, additional, Morita, Kumiko, additional, Surber, Christian, additional, Cork, Michael, additional, Cooke, Alison, additional, Tran, Lien, additional, Askie, Lisa M, additional, Duley, Lelia, additional, Chalmers, Joanne R, additional, Williams, Hywel C, additional, and Boyle, Robert J, additional

Published
2020
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141. Detection of allergic reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites.

Author

Inuzuka, Yusuke, Yamamoto‐Hanada, Kiwako, Nakamura, Tatsuro, Shimosawa, Tatsuo, Murata, Takahisa, and Ohya, Yukihiro

Subjects
*ALLERGIES, *GOLD standard, *LIQUID chromatography-mass spectrometry, *SUBLINGUAL immunotherapy
Abstract

Applying urinary PGDM as a biomarker for OFC could improve the safety of the FA diagnostic procedure by preventing severe allergic reactions, such as anaphylaxis, during an OFC. Urinary prostaglandin D2 metabolite (PDGM) levels increased in children with acute allergic reactions to foods Urinary PGDM were also increased in children with indeterminate food challenge outcomes compared to non-reactors These preliminary data suggest that urinary PGDM might be a useful biomarker for food challenges To the Editor, Oral food challenge (OFC) is a gold standard diagnostic method for food allergy (FA).1 Positive or negative OFC results are judged by an experienced physician based on objective allergic signs without reference to accurate biomarkers. In summary, urinary PGDM is a novel, noninvasive biomarker for detecting immediate food-induced allergic reactions, including subtle allergic reactions. [Extracted from the article]

Published
2022
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142. Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort.

Author

Yamamoto-Hanada, Kiwako, Suzuki, Yuichi, Yang, Limin, Saito-Abe, Mayako, Sato, Miori, Mezawa, Hidetoshi, Nishizato, Minaho, Kato, Noriko, Ito, Yoshiya, Hashimoto, Koichi, and Ohya, Yukihiro

Subjects
*FOOD allergy, *ECZEMA, *BODY mass index, *SKIN inflammation, *ATOPIC dermatitis
Abstract

Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height, and body mass index (BMI), in addition to food allergy in a birth cohort among infants. This study design was a nationwide, multicenter, prospective birth cohort study—the Japan Environment and Children's Study (JECS). Generalized linear models were fitted for z scores of weight, height, BMI, and food allergy to evaluate the relationship between eczema and these outcomes for infants at age1, 2, and 3 years. Persistent eczema was negatively associated with height at the age of 2 years (estimated coefficient, −0.127; 95% confidence interval [CI], −0.16 to −0.095) and 3 years (−0.177; 95% CI, −0.214 to −0.139). The same tendency was also observed with weight and BMI. Early disease onset at younger than 1 year and persistent eczema had the strongest association with development of food allergy at age 3 years (OR, 11.794; 95% CI, 10.721–12.975). One phenotype of eczema with early-onset and persistent disease creates a risk of both physical growth impairment and development of food allergy. Infants who present with the early-onset and persistent type of eczema should be carefully evaluated daily for impaired physical growth and development of food allergy. [ABSTRACT FROM AUTHOR]

Published
2021
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143. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study

Author

Tsuji, Mayumi, Koriyama, Chihaya, Ishihara, Yasuhiro, Yamamoto, Megumi, Yamamoto-Hanada, Kiwako, Kanatani, Kumiko, Bamai, Yu Ait, Onishi, Kazunari, Senju, Ayako, Araki, Shunsuke, Shibata, Eiji, Morokuma, Seiichi, Sanefuji, Masafumi, Kitazawa, Hiroshi, Saito, Mayako, Umezawa, Masakazu, Onoda, Atsuto, Kusuhara, Koichi, Tanaka, Rie, Kawamoto, Toshihiro, the Japan Environment & Children’s Study Group, Tsuji, Mayumi, Koriyama, Chihaya, Ishihara, Yasuhiro, Yamamoto, Megumi, Yamamoto-Hanada, Kiwako, Kanatani, Kumiko, Bamai, Yu Ait, Onishi, Kazunari, Senju, Ayako, Araki, Shunsuke, Shibata, Eiji, Morokuma, Seiichi, Sanefuji, Masafumi, Kitazawa, Hiroshi, Saito, Mayako, Umezawa, Masakazu, Onoda, Atsuto, Kusuhara, Koichi, Tanaka, Rie, Kawamoto, Toshihiro, and the Japan Environment & Children’s Study Group

Abstract

Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children. Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second=third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35UA=mL, and the metal levels were divided into quartiles. Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations. Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women., This work was supported by the Ministry of the Environment, Japan., Supplementary data related to this article can be found at https://doi.org/10.2188/jea.JE20180098.

Published
2019

146. Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children's Study.

Author

Saito-Abe, Mayko, Yamamoto-Hanada, Kiwako, Pak, Kyongsun, Sato, Miori, Irahara, Makoto, Mezawa, Hidetoshi, Sasaki, Hatoko, Nishizato, Minaho, Ishitsuka, Kazue, Konishi, Mizuho, Yang, Limin, Ohya, Yukihiro, and Suzuki, Kohta

Subjects
*ALLERGIC conjunctivitis, *PREGNANCY outcomes, *PREMATURE rupture of fetal membranes, *PREMATURE labor, *ALLERGIES, *PREGNANT women
Abstract

Introduction: Previous studies have reported that maternal asthma increases the risk of preterm birth. We hypothesized that inflammatory reactions caused by allergic diseases might affect the uterine environment and, subsequently, perinatal outcomes. The objective of this study was to examine the associations between allergic features among mothers and preterm pregnancy outcomes in a nationwide birth cohort. Methods: We analyzed data from pregnant women obtained from the Japanese Environment and Children's Study (JECS), a nationwide general birth cohort study. We used binomial and multinomial logistic regression models to examine the associations between maternal allergic features and preterm birth, threatened preterm labor (TPL), and preterm premature rupture of the membrane (PPROM). Results: A total of 97,683 pregnant women were included. Prevalence of preterm birth, TPL, and PPROM was 4.7, 19.6, and 1.2%, respectively. Maternal history of allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, food allergy, drug allergy, and contact dermatitis) increased the risk of TPL(adjusted odds ratio [aOR] = 1.11 [95% CI: 1.06–1.17], aOR = 1.12 [1.08–1.16], aOR = 1.10 [1.04–1.16], aOR = 1.17 [1.09–1.26], aOR = 1.35 [1.23–1.48], and aOR = 1.34 [1.20–1.49], respectively). Although some maternal allergic features showed a negative association with preterm birth, the variables affecting preterm birth differed according to the gestational age of the fetus (22–33 weeks vs. 34–36 weeks). There were no significant associations between maternal allergic features and PPROM. Conclusion: Maternal allergic disease, except atopic dermatitis, may increase the risk of TPL. Comorbidity of maternal allergic disorders and perinatal adverse outcomes require further investigation. [ABSTRACT FROM AUTHOR]

Published
2021
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147. Dietary supplement use in elementary school children: a Japanese web-based survey.

Author

Ishitsuka, Kazue, Sasaki, Satoshi, Mezawa, Hidetoshi, Konishi, Mizuho, Igarashi, Maki, Yamamoto-Hanada, Kiwako, Nakayama, Shoji F., and Ohya, Yukihiro

Abstract

Background: A variety of dietary supplements are commercially available. However, the efficacy and safety of dietary supplement use in children are not well established. Understanding dietary supplement use is important for developing public health policy regarding dietary supplements. This study aimed to investigate the types of dietary supplements used and characteristics of dietary supplement users among Japanese elementary school children. Method: We conducted a cross-sectional web-based questionnaire study. Dietary supplement use, socio-demographics, and health-related behaviors were assessed through mother-reported questionnaire. Types of dietary supplements were identified based on ingredient using product barcodes and brand names. Multivariate logistic regression analysis was conducted to investigate the socio-demographics and health-related behaviors associated with supplement use. Results: Among 4933 children, 333 (6.8%) were identified as dietary supplement users. The most common supplement was amino acids or protein (1.4%), followed by n–3 fatty acids or fish oil (1.0%), probiotics (1.0%), multivitamins (0.9%), multivitamin-minerals (0.8%), and botanicals (0.8%). Overall, any dietary supplement use was significantly associated with the highest frequency of sports participation (odds ratio [OR], 2.58; 95% confidence interval [CI], 1.65–4.02), highest household income (OR, 1.87; 95% CI, 1.13–3.10), highest maternal educational level (OR, 1.82; 95% CI, 1.31–2.52), and male sex (OR, 1.38; 95% CI, 1.09–1.75). The highest frequency of sports participation was significantly associated with higher odds of use of amino acids or protein (OR, 6.06; 95% CI, 1.78–20.6) and multivitamins (OR, 3.56; 95% CI, 1.11–11.5), compared to the lowest frequency of sports participation. Conclusion: This study showed that Japanese children primarily use non-vitamin, non-mineral supplements. Non-vitamin, non-mineral supplements should thus be included in future studies aimed at monitoring dietary supplement use. We also found that dietary supplement use in children was associated with sports participation. Guidelines for dietary supplement use for children, in particular sport participants, are needed. [ABSTRACT FROM AUTHOR]

Published
2021
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148. MOESM1 of Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study)â protocol for a randomized controlled trial

Author

Yamamoto-Hanada, Kiwako, Kobayashi, Tohru, Williams, Hywel, Mikami, Masashi, Saito-Abe, Mayako, Morita, Kumiko, Natsume, Osamu, Miori Sato, Iwama, Motoko, Miyaji, Yumiko, Miyata, Makiko, Inagaki, Shinichiro, Fukuie Tatsuki, Narita Masami, Nakayama, Shoji, Kido, Hiroshi, Saito, Hirohisa, and Ohya, Yukihiro

Abstract

Additional file 1. PACI Study Protocol version 1.2.

Published
2018
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150. Clinical practice guidelines for the management of atopic dermatitis 2018

Author

Katoh, Norito, primary, Ohya, Yukihiro, additional, Ikeda, Masanori, additional, Ebihara, Tamotsu, additional, Katayama, Ichiro, additional, Saeki, Hidehisa, additional, Shimojo, Naoki, additional, Tanaka, Akio, additional, Nakahara, Takeshi, additional, Nagao, Mizuho, additional, Hide, Michihiro, additional, Fujita, Yuji, additional, Fujisawa, Takao, additional, Futamura, Masaki, additional, Masuda, Koji, additional, Murota, Hiroyuki, additional, and Yamamoto‐Hanada, Kiwako, additional

Published
2019
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