101. Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers.
- Author
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Takanabe-Mori R, Ono K, Wada H, Takaya T, Ura S, Yamakage H, Satoh-Asahara N, Shimatsu A, Takahashi Y, Fujita M, Fujita Y, Sawamura T, and Hasegawa K
- Subjects
- Aged, Atherosclerosis blood, Atherosclerosis etiology, Biomarkers blood, C-Reactive Protein metabolism, Female, Humans, Inflammation Mediators blood, Male, Middle Aged, Oxidative Stress, Risk Factors, Solubility, Scavenger Receptors, Class E blood, Smoking adverse effects, Smoking blood, Vasculitis blood, Vasculitis etiology
- Abstract
Aim: Smoking induces vascular inflammation and increases the risk of cardiovascular events. Lectinlike oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that is induced by oxidative stress and is associated with atherosclerotic plaque formation and destabilization. LOX-1 interacts with C-reactive protein (CRP) and plays an important role in inflammatory diseases. We therefore hypothesized that LOX-1 may be involved in the onset of smoking-induced vascular inflammation., Methods: We measured the soluble LOX-1 (sLOX-1) levels in sera obtained from 207 current smokers., Results: The serum sLOX-1 levels positively correlated with various smoking variables, such as the number of cigarettes smoked per day (r= 0.150, p<0.05), the expired air carbon monoxide (CO) concentrations (r= 0.198, p<0.005) and the Fagerstrom test for nicotine dependence scores (r= 0.190, p<0.01). The serum levels of sLOX-1 also correlated with those of a representative inflammatory marker, the serum high-sensitivity CRP level (hsCRP; r= 0.232, p<0.005). A multivariate regression analysis revealed the independent determinants of the serum sLOX-1 level to be the expired air CO concentration (β= 0.182, p<0.05) and the hsCRP level (β= 0.213, p<0.01)., Conclusions: The serum sLOX-1 level was found to increase in close association with both the smoking-related variables and the inflammatory marker hsCRP. These findings suggest that LOX-1 may therefore play an important role in the onset of smoking-induced inflammation and atherosclerosis in humans.
- Published
- 2013
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