101. Three novel members of angucycline group from Streptomyces sp. N05WA963
- Author
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Ding Yanbo, Jingtong Zhu, Zhihui Zheng, Qin Jiang, Ke Aibing, Weili Hao, Yuling Fan, Xinhua Lu, Xiao Ren, Jie Lin, and Hua Zhang
- Subjects
Pharmacology ,Antifungal ,Anthracycline ,medicine.drug_class ,Stereochemistry ,Antiparasitic ,Spectrum Analysis ,Anthraquinones ,Antineoplastic Agents ,Biology ,biology.organism_classification ,Streptomyces ,Beta-lactam ,chemistry.chemical_compound ,chemistry ,Neoplasms ,Drug Discovery ,medicine ,Humans ,Anthracyclines ,Cancer cell lines ,Spectrum analysis ,Spectral data ,Cell Proliferation - Abstract
Three novel members of angucycline family named N05WA963A (1), B (2) and D (4), together with a new anthracycline named N05WA963C (3) were isolated from the culture broth of Streptomyces sp. N05WA963. The structures were elucidated on the basis of comprehensive spectral data analysis. All four compounds have shown antiproliferative effects on a panel of cancer cell lines such as SW620, K-562, MDA-MB-231, YES-4, T-98 and U251SP.
- Published
- 2011