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634 results on '"YAMAGUCHI, TOMOHIKO"'

101. Petahertz optical drive with wide-bandgap materials

Author

Mashiko, Hiroki, primary, Oguri, Katsuya, additional, Chisuga, Yuta, additional, Masuda, Hiroyuki, additional, Yamaguchi, Tomohiko, additional, Suda, Akira, additional, Katayama, Ikufumi, additional, Takeda, Jun, additional, and Gotoh, Hideki, additional

Published
2017
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105. Insulinoma‐associated protein 1 expression in pancreatic neuroendocrine tumours in endoscopic ultrasound‐guided fine‐needle aspiration cytology: An analysis of 14 patients.

Author

Takase, Yorihiko, Naito, Yoshiki, Okabe, Yoshinobu, Ishida, Yusuke, Yamaguchi, Tomohiko, Abe, Hideyuki, Murata, Kazuya, Ito, Takaaki, Tanigawa, Masahiko, Kawahara, Akihiko, Yano, Hirohisa, and Akiba, Jun

Subjects
INSULINOMA, NEUROENDOCRINE tumors, CYTOLOGY, ADENOCARCINOMA, IMMUNOCYTOCHEMISTRY
Abstract

Background: Insulinoma‐associated protein 1 (INSM1) has been reported to be a useful marker for diagnosing pancreatic neuroendocrine tumours (PNETs). However, INSM1 expression in endoscopic ultrasound‐guided fine needle aspiration cytology has not been examined. We evaluated INSM1 expression in the cytology of cases diagnosed with PNETs. Methods: We immunocytochemically stained INSM1 and Ki‐67 in 14 PNET cases, and according to the 2017 World Health Organisation criteria, seven PNET Grade 1 cases, four Grade 2 cases and three Grade 3/neuroendocrine carcinoma cases were identified. As a control for INSM1 and Ki‐67 expression, we used cytological specimens from 15 cases of pancreatic ductal adenocarcinoma. Results: In PNET cases, INSM1‐expressing tumour cells were identified in all cytological specimens of PNET. The median INSM1 expression rate in Grade 1 cases was 49.8% (mean ± standard deviation: 55.1 ± 12.5%, min: 39.3%, max: 74.1%), and in Grade 2 and Grade 3/neuroendocrine carcinoma cases was 81.1% (mean ± standard deviation: 77.6 ± 18.6%, min: 50.3%, max: 100%). However, there was no correlation between INSM1 and Ki‐67 expression (r = −0.15). The median expression rate in PNET cases was 64.3%, which was significantly higher than that in pancreatic ductal adenocarcinoma cases (P < 0.0001). Conclusion: INSM1 immunocytochemistry of cytological specimens obtained from endoscopic ultrasound‐guided fine needle aspiration cytology can accurately diagnose PNETs; therefore, INSM1 could be an important diagnostic tool in assessing therapeutic strategies, including molecular‐targeted therapy. Recently, neuroendocrine markers such as SYP, CGA, and NCAM have been used with high specificity and sensitivity for PNETs. However, there are similarities in cell structure and immunocytochemistry between pancreatic solid tumors. We reported INSM1 positivity in all histological specimens of PNETs examined including high grade PNETs. This can be considered a useful biomarker. [ABSTRACT FROM AUTHOR]

Published
2019
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106. Tranexamic Acid Ameliorates Nonmelanoma Skin Cancer Induced by Long‐term Ultraviolet A Irradiation.

Author

Hiramoto, Keiichi, Yamate, Yurika, Sugiyama, Daijiro, Matsuda, Kazunari, Iizuka, Yasutaka, and Yamaguchi, Tomohiko

Subjects
PLASMIN, TRANEXAMIC acid, SKIN cancer
Abstract

To date, there have been no treatments developed to ameliorate nonmelanoma skin cancer induced by long‐term exposure to ultraviolet A (UVA) irradiation. In this study, we examined the effects of tranexamic acid (trans‐4‐aminomethyl cyclohexanecarboxylic acid) on long‐term UVA‐induced skin cancer. We exposed the dorsal skin of male hairless mice to UVA at a dose of 110 kJ m−2 using an FL20SBLB‐A lamp three times weekly for 15 weeks after application of 7,12‐dimethylbenz [a] anthracene (DMBA). During the experimental period, the mice were administered tranexamic acid (750 mg kg−1 day−1) three times weekly. We found that cancer development was ameliorated by administration of tranexamic acid. Furthermore, tranexamic acid treatment was observed to suppress increases in the plasma levels of matrix metalloproteinase‐9 and interleukin (IL)‐6, and skin expression of plasmin, CC chemokine 2, macrophages, signal transducer and activator of transcription (STAT)3, cyclin D and vascular endothelial growth factor (VEGF)‐A that occurred in mice subjected to long‐term UVA irradiation. These results indicated that the nonmelanoma skin cancer induced by DMBA+UVA long‐term irradiation is ameliorated by tranexamic acid through regulation of the plasmin/macrophage/IL‐6/STAT3/cyclin D signal transmission pathway. In addition, this ameliorative effect against skin cancer may be mediated via inhibition of the IL‐6‐induced expression of VEGF‐A. This experiment indicated that the nonmelanoma skin cancer induced by DMBA + UVA long‐term irradiation is ameliorated by tranexamic acid through regulation of the plasmin/macrophage/IL‐6/STAT3/cyclin D signal transmission pathway. In addition, this ameliorative effect against skin cancer may be mediated via inhibition of the IL‐6‐induced expression of VEGF‐A. From these things, Administration of tranexamic acid, a safe and inexpensive agent, may thus represent an effective treatment for the prevention of skin cancer induced by long‐term UV exposure. [ABSTRACT FROM AUTHOR]

Published
2019
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107. Self-Oscillation of polymer chains with rhythmical soluble-insoluble changes

Author

Yoshida, Ryo, Sakai, Takamasa, Shoji, Ito, and Yamaguchi, Tomohiko

Subjects
Polymers -- Research, Belousov-Zhabotinskii reaction -- Observations, Ruthenium -- Chemical properties, Chemistry
Abstract

The ruthenium catalyst for the Belousov-Zhabotinsky reaction was polymerized by using N-isopropylacrylamide and dissolved into the solution containing the BZ substrates. In this polymer solution system, the chemical energy of the BZ reaction was converted into the optical rhythm through conformational changes of the polymer.

Published
2002

111. Granulocyte colony-stimulating factor-producing pancreatic anaplastic carcinoma in ascitic fluid at initial diagnosis: A case report

Author

Kubota, Nao, primary, Naito, Yoshiki, additional, Kawahara, Akihiko, additional, Taira, Tomoki, additional, Yamaguchi, Tomohiko, additional, Yoshida, Tomoko, additional, Abe, Hideyuki, additional, Takase, Yorihiko, additional, Fukumitsu, Chihiro, additional, Murata, Kazuya, additional, Ishida, Yusuke, additional, Okabe, Yoshinobu, additional, Kimura, Yoshizo, additional, Tanigawa, Masahiko, additional, Mihara, Yutaro, additional, Nakayama, Masamichi, additional, Yamaguchi, Rin, additional, Akiba, Jun, additional, and Yano, Hirohisa, additional

Published
2017
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119. Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from <italic>Trypanosoma brucei</italic>.

Author

Kubota, Tomomi, Tani, Osamu, Yamaguchi, Tomohiko, Namatame, Ichiji, Sakashita, Hitoshi, Furukawa, Koji, and Yamasaki, Kazuhiko

Subjects
CRYSTAL structure, DIHYDROOROTATE dehydrogenase, TRYPANOSOMA brucei, FLAVIN mononucleotide, HYDROGEN bonding
Abstract

Dihydroorotate dehydrogenase (DHODH) is a flavin‐binding enzyme essential for pyrimidine biosynthesis, which converts dihydroorotate to orotate. Three‐dimensional structures of cytosolic DHODH of parasitic protozoa are of interest in drug discovery for neglected tropical diseases, especially because these enzymes possess significantly different structural and functional properties from the membrane‐associated human enzyme. The existing crystal structures of the flavin mononucleotide (FMN)‐bound DHODHs reveal a number of interactions stabilizing FMN. However, to understand the binding mechanism correctly, it is necessary to compare the structures of the FMN‐bound and FMN‐free forms, because the protein moiety of the former is not necessarily the same as the latter. Here, we prepared the FMN‐free DHODH of Trypanosoma brucei using an Escherichia coli overexpression system. Although this apoform lacks enzymatic activity, simple incubation with FMN activated the enzyme. It was stable enough to be crystallized, enabling us to determine its structure by X‐ray crystallography at 1.6 Å resolution. We also determined the FMN‐bound form at 1.8 Å resolution. Although the two structures have essentially the same scaffold, we observed flipping of a peptide‐bond plane in the vicinity of the FMN‐binding site, accompanied by an alternative hydrogen‐bonding pattern. Comparisons of B factors of the protein main chain revealed that binding of FMN decreased flexibility of most of the residues at the FMN‐binding site, but increased flexibility of a lid‐like loop structure over the active center. This increase was ascribed to a conformational change in an FMN‐contacting residue, Asn195, which induced a rearrangement of a hydrogen‐bond network of the residues comprising the lid. [ABSTRACT FROM AUTHOR]

Published
2018
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120. Heat of Vaporization of Mixtures

Author

Akasaka Ryo, Yamaguchi Tomohiko, and Ito Takehiro

Subjects
Materials science, Mechanical Engineering, Boiling, Condensation, Vaporization, Evaporation, Thermodynamics, Enthalpy of vaporization, Entropy of vaporization, Condensed Matter Physics, General expression, Constant (mathematics)
Abstract

The general expression for heat of vaporization of a mixture at constant pressure, that at constant temperature, and that at constant pressure, temperature and composition are derived. The third expression is related to the liquid-vapor interface where steady vaporization or condensation is taking place. Numerical examples are shown for binary mixture of HCFC(R)22-HCFC(R)123.

Published
1996
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121. Assessment of the ThinPrep method for endoscopic ultrasound-guided fine needle aspirates

Author

Sata Michio, Sugiyama Gen, Taira Tomoki, Kawahara Akihiko, Tsuruta Osamu, Ishida Yusuke, Yasumoto Makiko, Kitasato Yuhei, Kinoshita Hisafumi, Kage Masayoshi, Yamaguchi Tomohiko, Kaji Ryohei, and Okabe Yoshinobu

Subjects
Endoscopic ultrasound, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gastroenterology, Medicine, Radiology, business, Surgery
Published
2011
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140. Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer

Author

Kibe, Shiro, primary, Yutani, Shigeru, additional, Motoyama, Satoru, additional, Nomura, Takanobu, additional, Tanaka, Natsuki, additional, Kawahara, Akihiko, additional, Yamaguchi, Tomohiko, additional, Matsueda, Satoko, additional, Komatsu, Nobukazu, additional, Miura, Masatomo, additional, Hinai, Yudai, additional, Hattori, Satoshi, additional, Yamada, Akira, additional, Kage, Masayoshi, additional, Itoh, Kyogo, additional, Akagi, Yoshito, additional, and Sasada, Tetsuro, additional

Published
2014
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141. Radiation effects on DNA content of cervical cancer cells: A rapid evaluation of radiation sensitivity by laser scanning cytometry

Author

FUJIYOSHI, NAOKI, primary, USHIJIMA, KIMIO, additional, KAWANO, KOUICHIRO, additional, FUJIYOSHI, KEIZO, additional, YAMAGUCHI, TOMOHIKO, additional, ARAKI, YUKO, additional, KAKUMA, TATSUYUKI, additional, WATANABE, SUMIKO, additional, KAKU, TSUNEHISA, additional, NISHIDA, TAKASHI, additional, and KAMURA, TOSHIHARU, additional

Published
2014
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142. Evaluation of immunohistochemistry using two different antibodies and procedures for primary lung adenocarcinoma harboring anaplastic lymphoma kinase rearrangement

Author

AKIBA, JUN, primary, KAWAHARA, AKIHIKO, additional, ABE, HIDEYUKI, additional, AZUMA, KOICHI, additional, YAMAGUCHI, TOMOHIKO, additional, TAIRA, TOMOKI, additional, FUKUMITSU, CHIHIRO, additional, TAKASE, YORIHIKO, additional, YASUMOTO, MAKIKO, additional, UMENO, YUMI, additional, TODOROKI, KEITA, additional, KURITA, TAKASHI, additional, YAMAGUCHI, RIN, additional, KAGE, MASAYOSHI, additional, and YANO, HIROHISA, additional

Published
2014
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148. Self-oscillating gel

Author

Yoshida, Ryo, Takahashi, Toshikazu, Yamaguchi, Tomohiko, and Ichijo, Hisao

Subjects
Oscillation -- Observations, Belousov-Zhabotinskii reaction -- Usage, Ruthenium -- Usage, Chemistry
Abstract

The mechanical oscillating gel of N-isopropylacrylamide, (IPAAm), having catalyst ruthenium(II)tris(2,2'-bipyridine), Ru(bpy)3 covalently bonded to the polymer chain, swells and deswells by oxidation and reduction of Ru(bpy), respectively. This is induced by Belousov Zhabotinsky reaction. The deviation in the phase transition temperature between Ru(II) and Ru(III) due to enhanced hydrophilicity of the latter causes contraction and expansion with the redox changes in Ru(bpy) at constant temperature.

Published
1996

150. Distinct Properties of Telmisartan on Agonistic Activities for Peroxisome Proliferator-Activated Receptorγamong Clinically Used Angiotensin II Receptor Blockers: Drug-Target Interaction Analyses

Author

Kakuta, Hirotoshi, primary, Kurosaki, Eiji, additional, Niimi, Tatsuya, additional, Gato, Katsuhiko, additional, Kawasaki, Yuko, additional, Suwa, Akira, additional, Honbou, Kazuya, additional, Yamaguchi, Tomohiko, additional, Okumura, Hiroyuki, additional, Sanagi, Masanao, additional, Tomura, Yuichi, additional, Orita, Masaya, additional, Yonemoto, Takako, additional, and Masuzaki, Hiroaki, additional

Published
2014
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