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Silicon quantum dots (SiQDs) feature unique optical properties and biological compatibility. The effective synthesis and surface modification of SiQDs in an aqueous solution can enrich the variety and applications. A new type of hybrid SiQDs was designed and fabricated by using two kinds of silicon precursors. (3-Aminopropyl)triethoxysilane (APTES), N-trimethylsilylimidazole (TSIM) and L -ascorbic acid were treated via an hydrothermal method. Two silicon precursors were used for the synthesis of SiQDs, which enabled the functioning of SiQDs and avoided its further modification. The hybrid SiQDs are endowed with amino and imidazole groups, higher nitrogen content, fluorescence intensity, and longer fluorescence lifetime. They were applied in the fluorescence detection of bovine hemoglobin with the linear range of 10 nM–10 μM and the detection limit of 12 nM. [ABSTRACT FROM AUTHOR]

The effects of sintering conditions including soaking time and packing powder on the thermal conductivity of Aluminum nitride (AlN) ceramics with Sm2O3 additives were investigated. The thermal conductivity values of AlN ceramics sintered were improved after increasing soaking time, but not considerably due to the interconnected secondary phases. While the specimen sintered without packing powder showed much higher thermal conductivity by 58 W·m−1·K−1 than the specimen sintered with packing powder. It is due to the removal of the secondary phase with poor thermal conductivity to a fairly low level, and the decreasing of the oxygen content via carbothermal reduction. [Copyright &y& Elsevier]

Background: Increasing interest and participation in engineering is vital if the United States is to create the larger technological and scientific labor force it needs to meet the challenges of the 21st century. Students' pathways into the different engineering majors provide important information for this effort. Purpose This study addresses which factors across life stages (pre‐high school, high school, and early college) are associated with engineering major choice. The quantitative analysis identifies which demographic characteristics and academic achievement variables are correlated with engineering major choice, whereas the qualitative analysis examines when and why students choose a specific engineering major. Methods: Informed by the life course perspective, this convergent mixed methods research study applies Logit regression and thematic analysis. Data sets include more than 20,000 observations of student‐level academic records (2001–2015) as well as interviews conducted with 20 students at a large, research‐intensive university in the Midwest. Results: Quantitative results indicate that student demographic factors and measures of academic achievement—including passing scores on advanced placement tests, scholastic aptitude test scores, and high school and college first‐year grade point averages—are associated with engineering major choice. Qualitative findings show that across the life stages, the source of social influence in engineering major choice varies; while family and teachers play larger roles before and during high school, peers and university personnel play larger roles in early college. Conclusion: The conceptual model comprehensively synthesizes the key factors associated with engineering major choice, highlighting the importance of demographic factors, academic achievement, social networks, and access to role models from pre‐high school, high school, and early college. [ABSTRACT FROM AUTHOR]

Gas-liquid two-phase flow exists in nuclear reactor evaporation, vehicle cooling, chemical production falling film evaporation and other processes, and the dynamic measurement of the interfacial wave is of great significance for industrial process monitoring and production optimization. Accurate identification and characterization of interfacial wave is an important prerequisite for scientific research and engineering practice. In this paper, interfacial wave measurement experiments have been carried out using an ultrasonic phased array system and measurement method to obtain gas-liquid phase interface measurement information in gas-liquid flow system. The liquid film thickness is extracted by fitting the gas-liquid interface through two-dimensional data matrix to ladder, detecting the liquid level data, and constructing a three-dimensional interfacial wave distribution model based on dynamic real-time data. The interfacial wave amplitude prediction correlation is developed using various machine learning regression models, which are optimized by parameters tuning algorithms. Laboratory results indicate that the wave amplitude prediction correlation is highly correlated with five inlet parameters, including superficial gas velocity, superficial liquid velocity, gas Reynolds number, liquid Reynolds number, and Lockhart-Martinelli (L-M) parameter. In the seven typical wave amplitude prediction correlations for stratified and plug flow, Least Squares Boosting (LSBoost) provided the best fit with MAPEs of 11.26 % and 18.42 %. The Gray Wolf Optimizer (GWO) is proposed and used to optimized the wave amplitude prediction correlation of LSBoost, and the MAPEs of optimized model are 4.38 % and 17.26 %. This paper provides a reliable method for accurate measurement and methodological analysis of interfacial wave spatial-temporal characteristic parameters of gas-liquid two-phase flow. • A three-dimensional measurement method of interfacial wave based on ultrasonic phased array is designed. • A three-dimensional interfacial wave distribution model based on dynamic real-time data is constructed. • The interfacial wave amplitude prediction correlation is established using multiple machine learning regression models. • Optimization of the wave amplitude prediction correlation by multiple parameter tuning algorithms. [ABSTRACT FROM AUTHOR]

A thinner endometrium has been linked to implantation failure, and various therapeutic strategies have been attempted to improve endometrial regeneration, including the use of mesenchymal stem cells (MSCs). However, low survival and retention rates of transplanted stem cells are main obstacles to efficient stem cell therapy in thin endometrium. Collagen type III is a key component of the extracellular matrix, plays a crucial role in promoting cell proliferation and differentiation, and has been identified as the major collagen expressed at the implantation site. Herein, composite alginate hydrogel containing recombinant type III collagen (rCo III) and umbilical cord mesenchymal stem cells are developed. rCo III serves as favorable bioactive molecule, displaying that rCo III administration promotes MSCs proliferation, stemness maintenance and migration. Moreover, rCo III administration enhances cell viability and migration of mouse endometrial stromal cells (ESCs). In a mouse model of thin endometrium, the Alg-rCo III hydrogel loaded with MSCs (MSC/Alg-rCo III) significantly induces endometrial regeneration and fertility enhancement in vivo. Further studies demonstrate that the MSC/Alg-rCo III hydrogel promoted endometrial function recovery partly by regulating mesenchymal-epithelial transition of ESCs. Taken together, the combination of Alg-rCo III hydrogel and MSCs has shown promising results in promoting endometrium regeneration and fertility restoration, and may provide new therapeutic options for endometrial disease. • MSCs/Alg-rCo III has excellent treatment effect on thin endometrium. • Introduction of type III collagen can promote the proliferation and stemness maintenance of MSCs. • Type III collagen promotes cell viability and migration of ESCs. • MSCs/Alg-rCo III hydrogel had therapeutic efficacy on endometrium thickness, glands recovery, angiogenesis and fertility restoration. • MSCs can promote endometrial repair through paracrine regulation of MET in ESCs. [ABSTRACT FROM AUTHOR]

• 3D model including elementary reaction kinetics for HT-PEMFCs is developed. • Adsorption and desorption of H 2 and CO are considered. • Sensitivities of elementary reaction rates are analyzed at various conditions. • Distributions of gaseous and surface species are obtained and discussed. • Influences of CO content and operating temperature are analyzed. High-temperature proton exchange membrane fuel cells have received lots of attention due to their high tolerance of impurities in the fuel gas. Many researchers have conducted experimental and numerical investigations to study the influence of carbon monoxide on performance of the high-temperature proton exchange membrane fuel cell. However, most numerical models use an empirical formula to consider the effect of adsorption and desorption of hydrogen and carbon monoxide. To more accurately study the influence mechanism of carbon monoxide as an impurity, a novel three-dimensional non-isothermal model considering elementary reactions of hydrogen and carbon monoxide for high-temperature proton exchange membrane fuel cells is developed in this study. The elementary reaction kinetics of the anodic catalytic layer adopts a six-step global reaction, and the adsorption processes, desorption processes, as well as electrochemical reactions are taken into account. This model is able to accurately predict the steady polarization curve of a high-temperature proton exchange membrane fuel cell fed by hydrogen containing different amounts of carbon monoxide. The sensitivities of elementary reaction rates in the voltage range of 0.4–0.9 V for the fuel cell fed by pure hydrogen or a mixture of hydrogen and carbon monoxide are analyzed. The rate-determination step is studied at different voltages. In addition, the distributions of gaseous species, surface species and reaction rates of all elementary reactions along different directions of the anode catalytic layer are presented. Finally, the influences of carbon monoxide content in the fuel gas and the operating temperature of a high-temperature proton exchange membrane fuel cell fed by a mixture of hydrogen and carbon monoxide are numerically studied. [ABSTRACT FROM AUTHOR]

It is an important issue to handle the surface contamination of nuclear facilities in the development of nuclear industry and nuclear emergency, especially in low temperature environment. In order to solve the problem of frozen, poor film-forming and strippability of the detergent at low temperature (below 0ºC), a novel ethyl cellulose/polyacrylate detergent was synthesized by free radical polymerization from ethyl cellulose, methyl methacrylate (MMA), butyl acrylate (BA), ethyl methacrylate (EMA), and isooctyl acrylate (IOA). The wettability of the detergent on different surfaces was determined by contact angle testing method. The film-forming and peeling property, rheological property of ethyl cellulose/polyacrylate detergent at low temperature were studied and the mechanical properties of the peeling film of ethyl cellulose/polyacrylate were tested. The decontamination of simulated radionuclide on the different plates by the ethyl cellulose/polyacrylate detergent at the temperature range of − 15ºC ~ 0ºC was also explored. The mechanism of simulated radionuclide transferring and decontamination was analyzed by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and energy spectrum (EDS). The results show that the detergent can not be frozen even at low temperature (−25ºC), and is easy to be sprayed, forming film and peeled off on the plates of stainless steel, ceramic tiles, glass, marble and concrete within 18 h at the low temperature range of − 15ºC ~ 0ºC. The decontamination efficiency of the ethyl cellulose/polyacrylate detergent is above 90% for radionuclide contamination on the surface of stainless steel, ceramic tiles, glass and marble plates, the decontamination efficiency on concrete is above 80%, at the temperature range of − 15ºC ~ 0ºC. The mechanism of simulated radionuclide transferring from the surface of contaminated plates into the detergent and being removed were diffusion, adhesion and embedding. Therefore, the ethyl cellulose/polyacrylate detergent has a good application prospect in surface decontamination of nuclear facility decommisioning due to its excellent fluidity, spraying, rheological property, film forming, strippable property, high decontamination efficiency at low temperature. [Display omitted] • A novel biomass-based EC/PA strippable detergent for surface decontamination at low temperature was prepared. • The EC/PA strippable detergent can form film and peeled off within 18 h at low temperature. • The decontamination efficiency of the EC/PA strippable detergent is almost above 90% on different plates. • The EC/PA film is degradable after service. [ABSTRACT FROM AUTHOR]

• Compared with the existing research, the tracking error signal with jamming is extrapolated in the condition that target orientation is arbitrary in the present paper, so a missile guidance loop can be constructed for analyzing the jamming effect. • The jamming effect of infrared jammer with different parameters is evaluated under dynamic engagement environment, and a practical jamming strategy is proposed based on the simulation results and theoretical analysis. • A reticle parameter identification method is proposed based on the cat-eye effect theory to set an effective jamming frequency. The infrared jammer is a common countermeasure for escaping the missile's attack, but a systemic analysis for jamming effectiveness in the target-missile engagement is absent. This paper analytically elaborates on the jamming effect for a spin-scan seeker with different parameters including jamming power, frequency, and phase. First, the mathematical expression of error signal for spin-scan seeker is derived, which provides the basis for constructing a missile guidance loop in which a target at arbitrary orientation employs a jammer. Next, the jamming effect of infrared jammer with different parameters is evaluated by the magnitude of miss distance. The simulation results and corresponding theoretical analysis indicate that a greater jamming power will increase the target survival probability and the range of jamming frequency and phase can be set more flexibly. Furthermore, the jamming will be valid if the jamming frequency is close to the reticle spin frequency under the condition of a greater jamming power, which forms the jamming strategy. Finally, a frequency identification method for a missile is designed by the cat-eye effect theory through signal processing and proved to be accurate, so the jamming strategy will be more utilizable in practice. The simulation results and analysis in the present paper will provide theoretical support for infrared jamming strategy. [ABSTRACT FROM AUTHOR]

• PanMfs adhered to zebrafish embryos, accumulating in larvae intestines. • PanMfs increased intestinal ROS levels, mitochondrial quantity, and disrupted lipid metabolism. • High-dose panmfs induced intestinal micromitophagy and apoptosis via Kras/MAPK. • PanMfs had toxic effects on early-life zebrafish, with higher doses displaying increased toxicity. Microplastic pollution, especially microfibers (MFs), presents a critical global environmental challenge in natural water bodies. Yet, research on the toxic effects of MFs, particularly during early fish development, is limited. This study aimed to investigate MFs' toxic effects and mechanisms on early-stage zebrafish. Zebrafish embryos were exposed to varying concentrations of polyacrylonitrile microfibers (PanMfs) for 7 days. Results revealed PanMfs adhering to the embryos' surface, with higher concentrations accelerating heart rate and causing pericardial edema in post-hatching larvae. Larvae ingested PanMfs, leading to their accumulation in the intestines and increased levels of reactive oxygen species (ROS) and mitochondrial quantity. Notably, lipid metabolism and calcium ion related signaling pathways underwent significant changes. Low concentration MFs affected glycometabolism pathways, with potential roles for aldob and cacng1a , exhibiting pronounced increases in ROS levels. High concentration of MFs had the most profound impact on signal transduction-related pathways, and possibly triggering micromitophagy and apoptosis in zebrafish intestinal epithelial cells through the Kras/MAPK signaling pathway, with potential roles for kras and mapk9. Although ROS increase was somewhat alleviated, it resulted in decreased survival rates and restricted growth in high concentration of MFs group. These findings highlight the significant threat of MFs to the early survival of fish. MFs pollution prevention and control hold great significance in the conservation of fishery resources. [ABSTRACT FROM AUTHOR]

The sensitive detection of analytes of different sizes is crucial significance for environmental protection, food safety and medical diagnostics. The confined space of nanochannels provides a location closest to the molecular reaction behaviors in real systems, thereby opening new opportunities for the precise detection of analytes. However, due to the susceptibility to external interference on the confined space of nanochannels, the high sensitivity nature of the current signals through the nanochannels is more troubling for the detection reliability. Combining highly sensitive optical signals with the sensitive current signals of solid-state nanochannels establishes a nanochannel detection platform based on electro-optical dual signals, potentially offering more sensitive, specific, and accuracy detection of analytes. This review summarizes the last five years of applications of solid-state nanochannels based on electro-optical dual signals in analytes detection. Firstly, the detection principles of solid-state nanochannels and the construction strategies of nanochannel electro-optical sensing platforms are discussed. Subsequently, the review comprehensively outlines the applications involving nanochannels with electrical signals combined with fluorescence signals, electrical signals combined with surface-enhanced Raman spectroscopy signals, and electrical signals combined with other optical signals in analyte detection. Additionally, the perspectives and difficulties of nanochannels are investigated on the basis of electro-optical dual signals., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Abnormal human immunoglobulin G (IgG) may induce the risk of immune system disorder, infectious diseases, tumors and so on. However, the current detection methods exhibit low sensitivity, which limits their practical application. In this work, an SPR optical fiber sensor (SPR-OFS) with high sensitivity is designed for label-free detection of human IgG. It is fabricated using a heterostructure optical fiber coated with Au film/AuNPs and the Ti 3 C 2 T x MXene biofunctionalized with goat anti-human IgG by polydopamine (PDA). In the experiment, the optimal thickness of the Ti 3 C 2 T x MXene was explored and determined to be about 93 nm by comprehensively considering the refractive index (RI) sensitivity and spectral bandwidth of the SPR sensor. When the largest figure of merit (FOM) is calculated to be 17.8279 RIU -1 , its RI sensitivity was ultimately found to be 2804.5 nm per RIU. The SPR-OFS was employed to detect human IgG within the concentration range of 0-30 μg mL -1 and its sensitivity is demonstrated to be 1.7046 nm (μg mL -1 ) -1 . The SPR-OFS was also proved to have excellent linearity, specificity and stability. The proposed sensor offers outstanding performance with simple fabrication, providing a cutting-edge bioanalytical platform with potential applications in clinical diagnosis.

Dysregulation of microRNA (miRNA) expression in cancer is a significant factor contributing to the progression of chemoresistance. The objective of this study is to explore the underlying mechanisms by which miR-34b-3p regulates chemoresistance in cervical cancer (CC). Previous findings have demonstrated low expression levels of miR-34b-3p in both CC chemoresistant cells and tissues. In this study, we initially characterize the behavior of SiHa/DDP cells which are CC cells resistant to the chemotherapeutic drug cisplatin (DDP). Subsequently, miR-34b-3p mimics are transfected into SiHa/DDP cells. It is observed that overexpression of miR-34b-3p substantially inhibits the proliferation, migration, and invasion abilities of SiHa/DDP cells and also enhances their sensitivity to DDP-induced cell death. Quantitative RT-PCR and western blot analysis further reveal elevated expression levels of STC2 and FN1 in SiHa/DDP cells, contrary to the expression pattern of miR-34b-3p. Moreover, STC2 and FN1 contribute to DDP resistance, proliferation, migration, invasion, and decreased apoptosis in CC cells. Through dual-luciferase assay analysis, we confirm that STC2 and FN1 are direct targets of miR-34b-3p in CC. Finally, rescue experiments demonstrate that overexpression of either STC2 or FN1 can partially reverse the inhibitory effects of miR-34b-3p overexpression on chemoresistance, proliferation, migration and invasion in CC cells. In conclusion, our findings support the role of miR-34b-3p as a tumor suppressor in CC. This study indicates that targeting the miR-34b-3p/STC2 or FN1 axis has potential therapeutic implications for overcoming chemoresistance in CC patients.

Purpose: This study evaluated the effects of chronic intermittent hypoxia (CIH) at different times on the mitochondria of mouse hearts and H9C2 cardiomyocytes to determine the role of the cannabinoid receptor 1 (CB1R)/adenosine 5'-monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) signaling pathway., Methods: Animal and cellular CIH models were prepared in an intermittent hypoxia chamber at different times. The cardiac function of mice was determined, and heart tissue and ultrastructural changes were observed. Apoptosis, reactive oxygen species (ROS), and mitochondrial membrane potential were detected, and MitoTracker™ staining was performed to observe cardiomyocyte mitochondria. Western blot, immunohistochemistry, and cellular immunofluorescence were also performed., Results: In the short-term CIH group, increases in mouse ejection fraction (EF) and heart rate (HR); mitochondrial division; ROS and mitochondrial membrane potential; and the expression levels of CB1R, AMPK, and PGC-1α were observed in vivo and in vitro. In the long-term CIH group, the EF and HR increased, the myocardial injury and mitochondrial damage were more severe, mitochondrial synthesis decreased, the apoptosis percentage and ROS increased, mitochondrial fragmentation increased, membrane potential decreased, CB1R expression increased, and AMPK and PGC-1α expression levels decreased. Targeted blocking of CB1R can increase AMPK and PGC-1α, reduce damage attributed to long-term CIH in mouse hearts and H9C2 cells, and promote mitochondrial synthesis., Conclusion: Short-term CIH can directly activate the AMPK/PGC-1α pathway, promote mitochondrial synthesis in cardiomyocytes, and protect cardiac structure and function. Long-term CIH can increase CB1R expression and inhibit the AMPK/PGC-1α pathway, resulting in structural damage, the disturbance of myocardial mitochondria synthesis, and further alterations in the cardiac structure. After targeted blocking of CB1R, levels of AMPK and PGC-1α increased, alleviating damage to the heart and cardiomyocytes caused by long-term CIH., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Purpose: To compare the static and dynamic occlusion of all-ceramic single crowns designed by mechanical and virtual articulators, by evalua6ng the accuracy of occlusal contacts of prostheses designed by virtual articulators and the feasibility of clinical application of CAD/CAM virtual articulators., Materials and Methods: Nine subjects with an average age of 27 years who needed crown repair were recruited. After preparation of the all-ceramic crowns, two zirconia crowns were designed and fabricated through digital procedures and traditional methods. The intraoral scanner, Geomagic software, and T-Scan analyzer were used to analyze the occlusal contact points, areas, and the occlusal force percentage peak before the treatment and after the two crowns were temporarily fixed., Results: There was a significant difference in the number of occlusal contact points and areas between the mechanical group and control group (preoperation group), but there was no obvious difference between the virtual group and control group. The occlusal contact overlapping areas of the virtual-control group were significantly larger than those of the mechanical-control group. The occlusal force percentage peak of the tested teeth was slightly larger in the mechanical group than in the virtual group., Conclusions: The posterior single crown designed by a virtual articulator restored the intercuspal occlusal better than one designed by a mechanical articulator, and it produced less dynamic occlusal interference. This finding suggests that virtual articulators can provide guidance for the design and adjustment of the occlusal surface of posterior single crown prostheses.

Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), a widely prescribed first-line antiepileptic drug for epilepsy and various neurological conditions, has been associated with a 4-fold increase in the risk of NTDs when used during pregnancy. Consequently, urgent efforts are required to identify innovative prevention and treatment approaches for VPA-induced NTDs. Studies have demonstrated that the disruption in the delicate balance between cell proliferation and apoptosis is a crucial factor contributing to NTDs induced by VPA. Encouragingly, our current data reveal that melatonin (MT) significantly inhibits apoptosis while promoting the restoration of neuroepithelial cell proliferation impaired by VPA. Moreover, further investigations demonstrate that MT substantially reduces the incidence of neural tube malformations resulted from VPA exposure, primarily by suppressing apoptosis through the modulation of intracellular reactive oxygen species levels. In addition, the Src/PI3K/ERK signaling pathway appears to play a pivotal role in VPA-induced NTDs, with significant inhibition observed in the affected samples. Notably, MT treatment successfully reinstates Src/PI3K/ERK signaling, thereby offering a potential underlying mechanism for the protective effects of MT against VPA-induced NTDs. In summary, our current study substantiates the considerable protective potential of MT in mitigating VPA-triggered NTDs, thereby offering valuable strategies for the clinical management of VPA-related birth defects.

To explore the immune defense mechanisms of the ancient crustacean fairy shrimp (B.kugenumaensis) and uncover antibacterial-related gene resources, the present study analyzed the pathological changes in B. kugenumaensis infected with E. anguillarum. Differential gene expression changes between the infected and uninfected groups were investigated through comparative transcriptome sequencing to elucidate the molecular responses to the infection. Under transmission electron microscopy, the intestinal mucosal structure of B. kugenumaensis was damaged, the microvilli disappeared, the number of mitochondria and endoplasmic reticulum increased, mitochondria vacuolated and arranged disordered. The transcriptome data indicated that a total of 250,520,580 clean reads were assembled into 66,502 unigenes, with an average length of 789 bp and an N50 length of 1326 bp. Following bacterial infection, approximately 2678 differentially expressed genes (DEGs) were identified, with 1732 genes upregulated and 946 genes downregulated. The detected DEGs related to immune responses, particularly involving apoptosis, lysosome, autophagy, phagosome, and MAPK signaling pathways. Moreover, 9 immunity-related genes with different expressions were confirmed by using real-time quantitative PCR (RT-qPCR). This study first reports the pathogenicity of E. anguillarum on B. kugenumaensis and speculates that immune effectors such as lysozyme and lectin, as well as apoptosis, lysosome, and the MAPK signaling pathway, play crucial roles in the innate immunity of fairy shrimp. These findings deepen our understanding of fairy shrimp immune regulatory mechanisms and provide a theoretical foundation for disease prevention and control., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

A laser-diode-pumped broadband and continuously frequency-tuned all-solid-state Nd:YVO 4 laser at 1064 nm with an output power of 200 mW is demonstrated. A RbTiOPO 4 (RTP) etalon and a piezoelectric-transducer (PZT) are utilized for coarse and fine frequency tuning, respectively. Dependence of the frequency excursion on the applied voltage to the RTP etalon and the displacement of the PZT is theoretically and experimentally investigated. A continuous frequency tuning of 14 GHz is conducted by synchronous adjustment of the RTP etalon and the PZT. The tuning covers more than 6 times the longitudinal mode spacing of a laser resonator without any mode hops.

A continuously frequency-tuned laser diode end-pumped Nd:YVO 4 laser at 1064 nm is demonstrated. A coated etalon and a piezoelectric-transducer (PZT) are utilized for coarse and fine frequency tuning, respectively. Broadband and linear frequency tuning without mode hops is conducted by the synchronous adjustment of the etalon and the PZT. Dependence of the frequency excursion on the displacement of the PZT and the tilting angle of the etalon are theoretically and experimentally investigated. A linear frequency tuning range up to 18 GHz without mode hops or frequency overlaps in a one-way non-stopped scanning is obtained. The maximum output power is 930 mW at 1064 nm, and the average frequency tuning speed is 1.24 GHz/s. Standard deviation of the frequency variation to a linear frequency tuning is estimated to be 186 MHz, indicating a high tuning linearity.