15,690 results on '"Xin, Yi"'
Search Results
102. Task-Specific Ionic Liquids Catalysts Efficiently Catalyze Atmospheric CO2 Gas Mixture to Cyclic Carbonates Under Mild Conditions
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Hui, Wei, Xu, Xin-Yi, and Wang, Hai-Jun
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- 2024
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103. Modified Sijunzi Granules Exhibit Hemostatic Effect by Activating Akt and Erk Signal Pathways via Regulating 5-HT and Its Receptors Levels
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Wang, Jun, Zhang, Xue-ying, Kang, Yan-hong, Zhang, Yun, Chen, Xin-yi, Zhou, Jia-li, and Ma, Wei
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- 2024
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104. Correlation of glymphatic system abnormalities with Parkinson’s disease progression: a clinical study based on non-invasive fMRI
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Meng, Jing-Cai, Shen, Ming-Qiang, Lu, Yan-Li, Feng, Hong-Xuan, Chen, Xin-Yi, Xu, Da-Qiang, Wu, Guan-Hui, Cheng, Qing-Zhang, Wang, Lin-Hui, and Gui, Qian
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- 2024
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105. The study of eleven contact binaries with mass ratios less than 0.1
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Liu, Xin-Yi, Li, Kai, Michel, Raul, Gao, Xiang, Gao, Xing, Liu, Fei, Yin, Shi-Peng, Wang, Xi, and Sun, Guo-You
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Multi-band photometric observations of eleven totally eclipsing contact binaries were carried out. Applying the Wilson-Devinney program, photometric solutions were obtained. There are two W-subtype systems, which are CRTS J133031.1+161202 and CRTS J154254.0+324652, and the rest systems are A-subtype systems. CRTS J154254.0+324652 has the highest fill-out factor with 94.3$\%$, and the lowest object is CRTS J155009.2+493639 with only 18.9$\%$. The mass ratios of the eleven systems are all less than 0.1, which means that they are extremely low mass ratio binary systems. We performed period variation investigation and found that the orbital periods of three systems decrease slowly, which may be caused by the angular momentum loss, and of six systems increase slowly, which indicates that the materials may transfer from the secondary component to the primary component. LAMOST low$-$resolution spectra of four objects were analyzed, and using the spectral subtraction technique, H$\alpha$ emission line was detected, which means that the four objects exhibit chromospheric activity. In order to understand their evolutionary status, the mass-luminosity and mass-radius diagrams were plotted. The two diagrams indicate that the primary component is in the main sequence evolution stage, and the secondary component is above TAMS, indicating that they are over-luminous. To determine whether the eleven systems are in stable state, the ratio of spin angular momentum to orbital angular momentum ($J_{s}/J_{o}$) and the instability parameters were calculated, and we argued that CRTS J234634.7+222824 is on the verge of a merger., Comment: 16 pages, 6 figures, and 11 tables, accepted by MNRAS
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- 2023
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106. Association between delayed ambulation and increased risk of adverse events after lumbar fusion surgery in elderly patients
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Shuai-Kang Wang, Xin-Yi Chai, Peng Wang, Chao Kong, and Shi-Bao Lu
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Lumbar degenerative disease ,Transforaminal lumbar interbody fusion ,Delayed ambulation ,Enhanced recovery after surgery ,Adverse events ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Purpose The relationship between delayed ambulation (DA) and postoperative adverse events (AEs) following transforaminal lumbar interbody fusion (TLIF) in elderly patients remains elusive. The aim of our study was to evaluate the effects of DA on the postoperative AEs including complications, readmission and prolonged length of hospital stay (LOS). Methods This was a retrospective analysis of a prospectively established database of elderly patients (aged 65 years and older) who underwent TLIF surgery. The early ambulation (EA) group was defined as patients ambulated within 48 h after surgery, whereas the delayed ambulation (DA) group was patients ambulated at a minimum of 48 h postoperatively. The DA patients were 1:1 propensity-score matched to the EA patients based on age, gender and the number of fused segments. Univariate analysis was used to compare postoperative outcomes between the two groups, and multivariate logistic regression analysis was used to identify risk factors for adverse events and DA. Results After excluding 125 patients for various reasons, 1025 patients (≤ 48 h: N = 659 and > 48 h: N = 366) were included in the final analysis. After propensity score matching, there were 326 matched patients in each group. There were no significant differences in the baseline data and the surgery-related variables between the two groups (p > 0.05). The patients in the DA group had a significant higher incidence of postoperative AEs (46.0% vs. 34.0%, p = 0.002) and longer LOS (p = 0.001). Multivariate logistic regression identified that age, operative time, diabetes, and DA were independently associated with postoperative AEs, whereas greater age, higher international normalized ratio, and intraoperative estimated blood loss were identified as independent risk factors for DA. Conclusions Delayed ambulation was an independent risk factor for postoperative AEs after TLIF in elderly patients. Older age, increased intraoperative blood loss and worse coagulation function were associated with delayed ambulation.
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- 2024
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107. An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
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Hoiyin Cheung, Tong-Zhou Yu, Xin Yi, Yan-Jiao Wu, Qi Wang, Xue Gu, Miao Xu, Meihua Cai, Wen Wen, Xin-Ni Li, Ying-Xiao Liu, Ying Sun, Jijian Zheng, Tian-Le Xu, Yan Luo, Ma-Zhong Zhang, and Wei-Guang Li
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Biology (General) ,QH301-705.5 - Abstract
Abstract Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, here we reveal its impact on the thalamic nucleus reuniens (RE) and interconnected hippocamposeptal circuits during fear extinction. Systemic or RE-specific administration of remimazolam impedes fear extinction by reducing RE activation through A type GABA receptors. Remimazolam enhances long-range GABAergic inhibition from lateral septum (LS) to RE, underlying the compromised fear extinction. RE projects to ventral hippocampus (vHPC), which in turn sends projections characterized by feed-forward inhibition to the GABAergic neurons of the LS. This is coupled with long-range GABAergic projections from the LS to RE, collectively constituting an overall positive feedback circuit construct that promotes fear extinction. RE-specific remimazolam negates the facilitation of fear extinction by disrupting this circuit. Thus, remimazolam in RE disrupts fear extinction caused by hippocamposeptal intermediation, offering mechanistic insights for the dilemma of combining anxiolytics with extinction-based exposure therapy.
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- 2024
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108. Data sonification of film capacitors
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Yong‐Xin Zhang, Di‐Fan Liu, Xin‐Yi Wei, Xin‐Jie Wang, Fang‐Yi Chen, Qi‐Kun Feng, Wen‐Yuan Cao, Wen‐Zhuo Dong, Faisal Mehmood Shah, Yu‐Xiao Liu, Zhi‐Yuan Wu, Jian‐Tao Wang, Shao‐Long Zhong, and Zhi‐Min Dang
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capacitors ,dielectric losses ,dielectric materials ,polymer films ,power capacitors ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract Film capacitors are playing an increasingly important role in power‐related fields, driven by the continuous development of dielectric materials and practical needs. Long‐term accumulation has also led to an increasing wealth of data related to film capacitors. Sonification opens up a new way for people to make good use of data from film capacitors. A framework for sonifying film capacitors data based on TwoTone is presented. Based on the analysis and discussion, it is clear that the sonification results can easily represent the monotonic variation pattern of film capacitors data. What's more, the sonification results increase the possibility that people pay attention to the changing trend of film capacitors data when there is no significant difference in the visual perception of the data. In addition to providing a new way of music generation of electrical equipment, the method proposed is expected to contribute to theory reference in typical scenarios, such as factory calibration of film capacitors, monitoring of film capacitor operation status, and presentation of statistical data of film capacitors' dielectric materials, which will help us to better understand the distribution characteristics of polymer films.
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- 2024
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109. Retinal vascular morphological characteristics in diabetic retinopathy: an artificial intelligence study using a transfer learning system to analyze ultra-wide field images
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Xin-Yi Deng, Hui Liu, Zheng-Xi Zhang, Han-Xiao Li, Jun Wang, Yi-Qi Chen, Jian-Bo Mao, Ming-Zhai Sun, and Li-Jun Shen
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diabetic retinopathy ,vascular morphology ,deep learning ,ultra-wide field imaging ,diabetic macular edema ,Ophthalmology ,RE1-994 - Abstract
AIM: To investigate the morphological characteristics of retinal vessels in patients with different severity of diabetic retinopathy (DR) and in patients with or without diabetic macular edema (DME). METHODS: The 239 eyes of DR patients and 100 eyes of healthy individuals were recruited for the study. The severity of DR patients was graded as mild, moderate and severe non-proliferative diabetic retinopathy (NPDR) according to the international clinical diabetic retinopathy (ICDR) disease severity scale classification, and retinal vascular morphology was quantitatively analyzed in ultra-wide field images using RU-net and transfer learning methods. The presence of DME was determined by optical coherence tomography (OCT), and differences in vascular morphological characteristics were compared between patients with and without DME. RESULTS: Retinal vessel segmentation using RU-net and transfer learning system had an accuracy of 99% and a Dice metric of 0.76. Compared with the healthy group, the DR group had smaller vessel angles (33.68±3.01 vs 37.78±1.60), smaller fractal dimension (Df) values (1.33±0.05 vs 1.41±0.03), less vessel density (1.12±0.44 vs 2.09±0.36) and fewer vascular branches (206.1±88.8 vs 396.5±91.3), all P
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- 2024
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110. CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis
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Xiao-Yu Zhang, Shan-Shan Li, Yu-Rong Gu, Le-Xin Xiao, Xin-Yi Ma, Xin-Ru Chen, Jia-Liang Wang, Chun-Hong Liao, Bing-Liang Lin, Yue-Hua Huang, and Yi-Fan Lian
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circPIAS1 ,Hepatocellular carcinoma ,miR-455-3p ,NUPR1 ,Ferroptosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed in HCC cases through bioinformatics analysis. This study aimed to investigate the oncogenic properties and mechanisms of circPIAS1 in HCC development. Methods Functional analyses were conducted to assess circPIAS1’s impact on HCC cell proliferation, migration, and ferroptosis. Xenograft mouse models were employed to evaluate circPIAS1’s effects on tumor growth and pulmonary metastasis in vivo. Bioinformatics analysis, RNA immunoprecipitation, and luciferase reporter assays were utilized to elucidate the molecular pathways influenced by circPIAS1. Additional techniques, including RNA pulldown, fluorescence in situ hybridization (FISH), chromatin immunoprecipitation (ChIP), qPCR, and western blotting, were used to further explore the underlying mechanisms. Results CircPIAS1 expression was elevated in HCC tissues and cells. Silencing circPIAS1 suppressed HCC cell proliferation and migration both in vitro and in vivo. Mechanically, circPIAS1 overexpression inhibited ferroptosis by competitively binding to miR-455-3p, leading to upregulation of Nuclear Protein 1 (NUPR1). Furthermore, NUPR1 promoted FTH1 transcription, enhancing iron storage in HCC cells and conferring resistance to ferroptosis. Treatment with ZZW-115, an NUPR1 inhibitor, reversed the tumor-promoting effects of circPIAS1 and sensitized HCC cells to lenvatinib. Conclusion This study highlights the critical role of circPIAS1 in HCC progression through modulation of ferroptosis. Targeting the circPIAS1/miR-455-3p/NUPR1/FTH1 regulatory axis may represent a promising therapeutic strategy for HCC.
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- 2024
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111. Spatial distribution of toponyms and formation mechanism in traditional villages in Western Hunan, China
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Yaliang Liu, Lu Liu, Ran Xu, Xin Yi, and Hui Qiu
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Traditional village ,Toponym ,Spatial distribution ,Formation mechanism ,Fine Arts ,Analytical chemistry ,QD71-142 - Abstract
Abstract Traditional village toponyms contain rich vernacular geographical information, profound cultural connotations, and social group memories. Studying the meanings and spatial distribution characteristics of traditional village toponyms and their formation mechanism is significant for the sustainable development and protection of the intangible culture of traditional villages. However, previous studies mainly focused on qualitative description combined with geospatial analysis techniques to explore their spatial distribution and influencing factors, but there has yet to be an in-depth study on why such a pattern is formed. Thus, this study employs statistics, a GIS kernel density estimation method, a geodetector, and historical data to examine the spatial distribution, influence factors, and formation mechanisms of various toponyms in traditional villages in western Hunan, China. The results show that (1) the toponyms in traditional villages in western Hunan can be categorized into natural and cultural landscape toponyms. Natural landscape toponyms predominate in the northwest, whereas cultural landscape toponyms are more concentrated in the southeast, with Huayuan, Longshan, and Dong Autonomous Counties as the primary focal points; (2)Natural toponyms are shaped by terrain, river proximity, and vegetation, whereas cultural toponyms cluster due to natural features and historic trail influence, mirroring the historical migration and settlement patterns in the development of western Hunan; (3)Multiple influencing factors, regulatory powers, and curing processes reveal the formation mechanism of the spatial patterns of toponyms. This study offers a novel lens for recognizing and understanding the characteristics of human settlement environments and culture in traditional villages. Moreover, the results of this study can provide scientific guidance for the cultural protection of traditional villages on a cross-regional scale.
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- 2024
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112. Adaptation mechanism of three Impatiens species to different habitats based on stem morphology, lignin and MYB4 gene
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Xin-Yi Li, Ze-Feng Li, Xiao-Li Zhang, Meng-Qing Yang, Pei-Qing Wu, Mei-Juan Huang, and Hai-Quan Huang
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Impatiens ,Stem morphological anatomy ,MYB4 gene ,Expression analysis ,Lignin ,Botany ,QK1-989 - Abstract
Abstract Background Impatiens is an important genus with rich species of garden plants, and its distribution is extremely extensive, which is reflected in its diverse ecological environment. However, the specific mechanisms of Impatiens’ adaptation to various environments and the mechanism related to lignin remain unclear. Results Three representative Impatiens species,Impatiens chlorosepala (wet, low degree of lignification), Impatiens uliginosa (aquatic, moderate degree of lignification) and Impatiens rubrostriata (terrestrial, high degree of lignification), were selected and analyzed for their anatomical structures, lignin content and composition, and lignin-related gene expression. There are significant differences in anatomical parameters among the stems of three Impatiens species, and the anatomical structure is consistent with the determination results of lignin content. Furthermore, the thickness of the xylem and cell walls, as well as the ratio of cell wall thickness to stem diameter have a strong correlation with lignin content. The anatomical structure and degree of lignification in Impatiens can be attributed to the plant's growth environment, morphology, and growth rate. Our analysis of lignin-related genes revealed a negative correlation between the MYB4 gene and lignin content. The MYB4 gene may control the lignin synthesis in Impatiens by controlling the structural genes involved in the lignin synthesis pathway, such as HCT, C3H, and COMT. Nonetheless, the regulation pathway differs between species of Impatiens. Conclusions This study demonstrated consistency between the stem anatomy of Impatiens and the results obtained from lignin content and composition analyses. It is speculated that MYB4 negatively regulates the lignin synthesis in the stems of three Impatiens species by regulating the expression of structural genes, and its regulation mechanism appears to vary across different Impatiens species. This study analyses the variations among different Impatiens plants in diverse habitats, and can guide further molecular investigations of lignin biosynthesis in Impatiens.
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- 2024
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113. Mogroside V reduced the excessive endoplasmic reticulum stress and mitigated the Ulcerative colitis induced by dextran sulfate sodium in mice
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Yue-Rong Tan, Si-Yang Shen, Xin-Yi Li, Peng-Fei Yi, Ben-Dong Fu, and Lu-Yuan Peng
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Mogroside V ,Ulcerative colitis ,Endoplasmic reticulum stress ,Apoptosis ,Medicine - Abstract
Abstract Ulcerative colitis (UC) is an idiopathic, chronic inflammatory condition of the colon, characterized by repeated attacks, a lack of effective treatment options, and significant physical and mental health complications for patients. The endoplasmic reticulum (ER) is a vital intracellular organelle in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) is induced when the body is exposed to adverse external stimuli. Numerous studies have shown that ERS-induced apoptosis plays a vital role in the pathogenesis of UC. Mogroside V (MV), an active ingredient of Monk fruit, has demonstrated excellent anti-inflammatory and antioxidant effects. In this study, we investigated the therapeutic effects of MV on dextran sulfate sodium (DSS)-induced UC and its potential mechanisms based on ERS. The results showed that MV exerted a protective effect against DSS-induced UC in mice as reflected by reduced DAI scores, increased colon length, reduced histological scores of the colon, and levels of pro-inflammatory cytokines, as well as decreased intestinal permeability. In addition, the expression of ERS pathway including BIP, PERK, eIF2α, ATF4, CHOP, as well as the apoptosis-related protein including Caspase-12, Bcl-2 and Bax, was found to be elevated in UC. However, MV treatment significantly inhibited the UC and reversed the expression of inflammation signaling pathway including ERS and ERS-induced apoptosis. Additionally, the addition of tunicamycin (Tm), an ERS activator, significantly weakened the therapeutic effect of MV on UC in mice. These findings suggest that MV may be a therapeutic agent for the treatment of DSS-induced UC by inhibiting the activation of the ERS-apoptosis pathway, and may provide a novel avenue for the treatment of UC.
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- 2024
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114. The chromosome-level genome and functional database accelerate research about biosynthesis of secondary metabolites in Rosa roxburghii
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Jiaotong Yang, Jingjie Zhang, Hengyu Yan, Xin Yi, Qi Pan, Yahua Liu, Mian Zhang, Jun Li, and Qiaoqiao Xiao
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R. Roxburghii ,Genome ,Functional annotation ,Database ,Metabolites biosynthesis ,Botany ,QK1-989 - Abstract
Abstract Rosa roxburghii Tratt, a valuable plant in China with long history, is famous for its fruit. It possesses various secondary metabolites, such as L-ascorbic acid (vitamin C), alkaloids and poly saccharides, which make it a high nutritional and medicinal value. Here we characterized the chromosome-level genome sequence of R. roxburghii, comprising seven pseudo-chromosomes with a total size of 531 Mb and a heterozygosity of 0.25%. We also annotated 45,226 coding gene loci after masking repeat elements. Orthologs for 90.1% of the Complete Single-Copy BUSCOs were found in the R. roxburghii annotation. By aligning with protein sequences from public platform, we annotated 85.89% genes from R. roxburghii. Comparative genomic analysis revealed that R. roxburghii diverged from Rosa chinensis approximately 5.58 to 13.17 million years ago, and no whole-genome duplication event occurred after the divergence from eudicots. To fully utilize this genomic resource, we constructed a genomic database RroFGD with various analysis tools. Otherwise, 69 enzyme genes involved in L-ascorbate biosynthesis were identified and a key enzyme in the biosynthesis of vitamin C, GDH (L-Gal-1-dehydrogenase), is used as an example to introduce the functions of the database. This genome and database will facilitate the future investigations into gene function and molecular breeding in R. roxburghii.
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- 2024
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115. CLK2 mediates IκBα-independent early termination of NF-κB activation by inducing cytoplasmic redistribution and degradation
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Shang-Ze Li, Qi-Peng Shu, Hai-Meng Zhou, Yu-Ying Liu, Meng-Qi Fan, Xin-Yi Liang, Lin-Zhi Qi, Ya-Nan He, Xue-Yi Liu, Xue-Hua Du, Xi-Chen Huang, Yu-Zhen Chen, Run-Lei Du, Yue-Xiu Liang, and Xiao-Dong Zhang
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Science - Abstract
Abstract Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pattern in the later stage of activation, and the mechanisms mediating the rapid termination of active NF-κB remain unclear. Here, we showed IκBα-independent rapid termination of nuclear NF-κB mediated by CLK2, which negatively regulated active NF-κB by phosphorylating the RelA/p65 subunit of NF-κB at Ser180 in the nucleus to limit its transcriptional activation through degradation and nuclear export. Depletion of CLK2 increased the production of inflammatory cytokines, reduced viral replication and increased the survival of the mice. Mechanistically, CLK2 phosphorylated RelA/p65 at Ser180 in the nucleus, leading to ubiquitin‒proteasome-mediated degradation and cytoplasmic redistribution. Importantly, a CLK2 inhibitor promoted cytokine production, reduced viral replication, and accelerated murine psoriasis. This study revealed an IκBα-independent mechanism of early-stage termination of NF-κB in which phosphorylated Ser180 RelA/p65 turned off posttranslational modifications associated with transcriptional activation, ultimately resulting in the degradation and nuclear export of RelA/p65 to inhibit excessive inflammatory activation. Our findings showed that the phosphorylation of RelA/p65 at Ser180 in the nucleus inhibits early-stage NF-κB activation, thereby mediating the negative regulation of NF-κB.
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- 2024
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116. Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy
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Ying Gao, Rong-Xin Lu, Yun Tang, Xin-Yi Yang, Hu Meng, Chang-Lin Zhao, Yi-Lu Chen, Feng Yan, and Qian Cao
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diabetic retinopathy ,neutrophil-to-lymphocyte ratio ,platelet-to-lymphocyte ratio ,systemic immune-inflammation index ,Ophthalmology ,RE1-994 - Abstract
AIM: To investigate systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) levels in patients with type 2 diabetes at different stages of diabetic retinopathy (DR). METHODS: This retrospective study included 141 patients with type 2 diabetes mellitus (DM): 45 without diabetic retinopathy (NDR), 47 with non-proliferative diabetic retinopathy (NPDR), and 49 with proliferative diabetic retinopathy (PDR). Complete blood counts were obtained, and NLR, PLR, and SII were calculated. The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic (ROC) curves. The relationships between DR stages and SII, PLR, and NLP were assessed using multivariate logistic regression. RESULTS: The average NLR, PLR, and SII were higher in the PDR group than in the NPDR group (P=0.011, 0.043, 0.009, respectively); higher in the NPDR group than in the NDR group (P
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- 2024
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117. Corn Silk Polysaccharide Reduces the Risk of Kidney Stone Formation by Reducing Oxidative Stress and Inhibiting COM Crystal Adhesion and Aggregation
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Bao-Li Heng, Fan-Yu Wu, Xin-Yi Tong, Guo-Jun Zou, and Jian-Ming Ouyang
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Chemistry ,QD1-999 - Published
- 2024
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118. Pharmacokinetic/pharmacodynamic evaluation of gamithromycin against rabbit pasteurellosis
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Xin-Yi Wei, Jing Zhang, Yin Zhang, Wen-Zhen Fu, Long-Gen Zhong, Yi-Duo Pan, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu, and Yu-Feng Zhou
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PK/PD ,Gamithromycin ,P. Multocida ,Rabbit ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Gamithromycin is an effective therapy for bovine and swine respiratory diseases but not utilized for rabbits. Given its potent activity against respiratory pathogens, we sought to determine the pharmacokinetic profiles, antimicrobial activity and target pharmacokinetic/pharmacodynamic (PK/PD) exposures associated with therapeutic effect of gamithromycin against Pasteurella multocida in rabbits. Results Gamithromycin showed favorable PK properties in rabbits, including high subcutaneous bioavailability (86.7 ± 10.7%) and low plasma protein binding (18.5–31.9%). PK analysis identified a mean plasma peak concentration (Cmax) of 1.64 ± 0.86 mg/L and terminal half-life (T1/2) of 31.5 ± 5.74 h after subcutaneous injection. For P. multocida, short post-antibiotic effects (PAE) (1.1–5.3 h) and post-antibiotic sub-inhibitory concentration effects (PA-SME) (6.6–9.1 h) were observed after exposure to gamithromycin at 1 to 4× minimal inhibitory concentration (MIC). Gamithromycin demonstrated concentration-dependent bactericidal activity and the PK/PD index area under the concentration-time curve over 24 h (AUC24h)/MIC correlated well with efficacy (R2 > 0.99). The plasma AUC24h/MIC ratios of gamithromycin associated with the bacteriostatic, bactericidal and bacterial eradication against P. multocida were 15.4, 24.9 and 27.8 h in rabbits, respectively. Conclusions Subcutaneous administration of 6 mg/kg gamithromycin reached therapeutic concentrations in rabbit plasma against P. multocida. The PK/PD ratios determined herein in combination with ex vivo activity and favorable rabbit PK indicate that gamithromycin may be used for the treatment of rabbit pasteurellosis.
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- 2024
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119. Biogated mesoporous silica nanoagents for inhibition of cell migration and combined cancer therapy
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Wu, Yu, Shi, Xiao-Jie, Dai, Xin-Yi, Song, Tian Shun, Li, Xiang-Ling, and Xie, Jing Jing
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- 2024
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120. Characterization of three novel stem rot pathogens and their antagonistic endophytic bacteria associated with Cistanche deserticola
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Zhou, Xin-Yi, Ban, Ya-Li, Wang, Cheng-Bin, Chen, Xin-Tao, Yang, Hong-Wang, and Feng, Yong-Jun
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- 2024
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121. Two-partite entanglement purification assisted by quantum-dot spins inside single-sided optical microcavities
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Xiu, Xiao-Ming, Liu, Si-Tong, Wang, Xin-Ying, Lv, Liu, Zhao, Zi-Lin, Yuan, Zi-Qing, Chen, Si-Ge, Zhang, Xin-Yi, Yang, Zi-Long, Ji, Yan-Qiang, and Dong, Li
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- 2024
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122. On the Oceanic/Laky Shallow-Water Dynamics through a Boussinesq-Burgers System
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Gao, Xin-Yi, Guo, Yong-Jiang, and Shan, Wen-Rui
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- 2024
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123. Novel Technologies to Enhance Nutrition Security and their Evolving Benefits and Concerns
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Sim, Shaun Yong Jie, primary, Chiang, Jie Hong, additional, Toh, Darel Wee Kiat, additional, Hua, Xin Yi, additional, Lee, Ruo Rou, additional, and (CJK) Henry, Christiani Jeyakumar, additional
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- 2024
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124. Search for heavy Majorana neutrinos at future lepton colliders
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Lu, Peng-Cheng, Si, Zong-Guo, Wang, Zhe, Yang, Xing-Hua, and Zhang, Xin-Yi
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High Energy Physics - Phenomenology - Abstract
The nonzero neutrino mass can be a signal for new physics beyond the standard model. To explain the tiny neutrino mass, we can extend the standard model with right-handed Majorana neutrinos in a low-scale seesaw mechanism, while the CP violation effect can be induced due to the CP phase in the interference of heavy Majorana neutrinos. The existence of heavy Majorana neutrinos may lead to lepton number violation processes, which can be used as a probe to search for the signal of heavy Majorana neutrinos. In this paper, we focus on the CP violation effect related to two generations of heavy Majorana neutrinos for $15$ GeV $
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- 2022
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125. Intrinsic and tunable quantum anomalous Hall effect and magnetic topological phases in XYBi2Te5
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Tang, Xin-Yi, Li, Zhe, Xue, Feng, Ji, Pengfei, Zhang, Zetao, Feng, Xiao, Xu, Yong, Wu, Quansheng, and He, Ke
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Condensed Matter - Materials Science - Abstract
By first-principles calculations, we study the magnetic and topological properties of XYBi2Te5-family (X, Y = Mn, Ni, V, Eu) compounds. The strongly coupled double magnetic atom-layers can significantly enhance the magnetic ordering temperature while keeping the topologically nontrivial properties. Particularly, NiVBi2Te5 is found to be a magnetic Weyl semimetal in bulk and a Chern insulator in thin film with both the Curie temperature (~150 K) and full gap well above 77 K. Ni2Bi2Te5, MnNiBi2Te5, NiVBi2Te5 and NiEuBi2Te5 exhibits intrinsic dynamic axion state. Among them, MnNiBi2Te5 has a Neel temperature over 200 K and Ni2Bi2Te5 even demonstrates antiferromagnetic order above room temperature. These results indicate an approach to realize high temperature quantum anomalous Hall effect and other topological quantum effects for practical applications.
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- 2022
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126. Photometric and spectroscopic studies of the long period low mass ratio deep contact binary KN Per
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Gao, Xin-Yi, Li, Kai, Cai, Ya-Wen, Guo, Ya-Ni, Gao, Xing, Wang, Xi, Yin, Shi-Peng, Liu, Fei, and Sun, Guo-You
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The photometric analysis and spectroscopic study of the long period low mass ratio deep contact binary KN Per were executed. The light curves of BV(RI)$_c$-band were from the Ningbo Bureau of Education and Xinjiang Observatory Telescope (NEXT) at the Xingming Observatory. Through the analysis of Wilson-Devinney (W-D) program, KN Per was found as an A-type low mass ratio deep contact binary (q=0.236, f=53.4\%). A cool spot applied on the primary component was introduced to explain the unequal maxima of the light curve. Based on the O-C analysis, we found that the rate of the increasing orbital period is $\dot{P}$ = 5.12 $\pm$ (0.30) $\times$ 10$^{-7}$ d/yr, meaning the mass transfer from the secondary component to the primary one. By analyzing the spectroscopic data, we detected chromospheric activity emission line indicators, which is corresponding to the light-curve analysis. 71 long period (P $>$ 0.5 days) contact binaries including our target were collected. The evolutionary states of all collected stars were investigated by the illustrations of mass-radius, mass-luminosity, and log M$_{T}$ - log J$_{o}$. The relations of some physical parameters were also determined. With the instability parameters of KN Per, we determined that it is a stable contact binary system at present., Comment: 20 pages, 11 figures,, and 10 tables, accepted by PASP
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- 2022
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127. Individuality and generality of intratumoral microbiome in the three most prevalent gynecological malignancies: an observational study
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Qin Xiao, Wen-jie Chen, Fei Wu, Xin-yi Zhang, Xia Li, Jing Wei, Ting-tao Chen, and Zhao-xia Liu
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intratumoral microbiome ,tumor bacteria ,16S amplicon high throughput sequencing ,cervical cancer ,ovarian cancer ,endometrial cancer ,Microbiology ,QR1-502 - Abstract
ABSTRACT Growing evidence have indicated the crucial role of intratumor microbiome in a variety of solid tumor. However, the intratumoral microbiome in gynecological malignancies is largely unknown. In the present study, a total of 90 Han patients, including 30 patients with cancer in cervix, ovary, and endometrium each were enrolled, the composition of intratumoral microbiome was assessed by 16S rDNA amplicon high throughput sequencing. We found that the diversity and metabolic potential of intratumoral microbiome in all three cancer types were very similar. Furthermore, all three cancer types shared a few taxa that collectively take up high relative abundance and positive rate, including Pseudomonas sp., Comamonadaceae gen. sp., Bradyrhizobium sp., Saccharomonospora sp., Cutibacterium acnes, Rubrobacter sp., Dialister micraerophilus, and Escherichia coli. Additionally, Haemophilus parainfluenzae and Paracoccus sp. in cervical cancer, Pelomonas sp. in ovarian cancer, and Enterococcus faecalis in endometrial cancer were identified by LDA to be a representative bacterial strain. In addition, in cervical cancer patients, alpha-fetoprotein (AFP) (correlation coefficient = −0.3714) was negatively correlated (r = 0.4, 95% CI: 0.03 to 0.7) with Rubrobacter sp. and CA199 (correlation coefficient = 0.3955) was positively associated (r = 0.4, 95% CI: 0.03 to 0.7) with Saccharomonospora sp.. In ovarian cancer patients, CA125 (correlation coefficient = −0.4451) was negatively correlated (r = −0.4, 95% CI: −0.7 to −0.09) with Porphyromonas sp.. In endometrial cancer patients, CEA (correlation coefficient = −0.3868) was negatively correlated (r = −0.4, 95% CI: −0.7 to −0.02) with Cutibacterium acnes. This study promoted our understanding of the intratumoral microbiome in gynecological malignancies.IMPORTANCEIn this study, we found the compositional spectrum of tumor microbes among gynecological malignancies were largely similar by sharing a few taxa and differentiated by substantial species owned uniquely. Certain species, mostly unreported, were identified to be associated with clinical characteristics. This study prompted our understanding of gynecological malignancies and offered evidence for tumor microbes affecting tumor biology among cancers in the female reproductive system.
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- 2024
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128. SAFE-MIL: a statistically interpretable framework for screening potential targeted therapy patients based on risk estimation
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Yanfang Guan, Zhengfa Xue, Jiayin Wang, Xinghao Ai, Rongrong Chen, Xin Yi, Shun Lu, and Yuqian Liu
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EGFR ,non-small cell lung cancer ,target therapy ,risk estimation ,Hosmer-Lemeshow test ,multi-instance learning ,Genetics ,QH426-470 - Abstract
Patients with the target gene mutation frequently derive significant clinical benefits from target therapy. However, differences in the abundance level of mutations among patients resulted in varying survival benefits, even among patients with the same target gene mutations. Currently, there is a lack of rational and interpretable models to assess the risk of treatment failure. In this study, we investigated the underlying coupled factors contributing to variations in medication sensitivity and established a statistically interpretable framework, named SAFE-MIL, for risk estimation. We first constructed an effectiveness label for each patient from the perspective of exploring the optimal grouping of patients’ positive judgment values and sampled patients into 600 and 1,000 groups, respectively, based on multi-instance learning (MIL). A novel and interpretable loss function was further designed based on the Hosmer-Lemeshow test for this framework. By integrating multi-instance learning with the Hosmer-Lemeshow test, SAFE-MIL is capable of accurately estimating the risk of drug treatment failure across diverse patient cohorts and providing the optimal threshold for assessing the risk stratification simultaneously. We conducted a comprehensive case study involving 457 non-small cell lung cancer patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors. Results demonstrate that SAFE-MIL outperforms traditional regression methods with higher accuracy and can accurately assess patients’ risk stratification. This underscores its ability to accurately capture inter-patient variability in risk while providing statistical interpretability. SAFE-MIL is able to effectively guide clinical decision-making regarding the use of drugs in targeted therapy and provides an interpretable computational framework for other patient stratification problems. The SAFE-MIL framework has proven its effectiveness in capturing inter-patient variability in risk and providing statistical interpretability. It outperforms traditional regression methods and can effectively guide clinical decision-making in the use of drugs for targeted therapy. SAFE-MIL offers a valuable interpretable computational framework that can be applied to other patient stratification problems, enhancing the precision of risk assessment in personalized medicine. The source code for SAFE-MIL is available for further exploration and application at https://github.com/Nevermore233/SAFE-MIL.
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- 2024
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129. Metal Contamination in Household Dust and Their Health Risk Assessment: A Study in Two Malaysian Cities
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Xin Yi Lim, Ting Fang Lye, and Joo Hui Tay
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Trace metals ,Indoor dust ,Exposure assessment ,Dust ingestion ,Environmental sciences ,GE1-350 ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
Investigating the composition of household dust can provide crucial insights into potential environmental and health implications. This study aimed to determine the concentration of selected metals in 30 household floor dust samples collected from two cities in Peninsular Malaysia, namely Melaka and Butterworth. The samples were collected using nylon socks attached to a vacuum cleaner nozzle during January-February 2021. All samples were sieved through a 200-µm sieve, acid-digested with aqua regia, and analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Mean metal concentrations decreased in the order of Fe>Al>Mg>Zn>Mn>Ba>Cu>Cr>Pb. Cd was not detected in any samples. The median concentrations of Al, Ba, and Mg from Melaka were significantly higher than those from Butterworth. Hazard indexes for all metals were less than one, indicating a low noncarcinogenic risk of exposure to occupants via inhalation, dust ingestion, and skin absorption. Statistical analyses revealed that the levels of metals in household dust were influenced by factors such as the location and age of the house, the presence of air conditioning, and the time since the last paint. This study highlights the presence of metals in indoor settings of different cities in Malaysia, providing fundamental data for future research in the field.
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- 2024
130. Reducing anxiety and enhancing satisfaction in thyroid patients with DietLens application during radioactive iodine therapy: A quasi-experimental study
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Xin Yi Seah, Xiang Cong Tham, Fazila Aloweni, Sandra Mei Yu Kua, Wei Ying Tham, and Siew Hoon Lim
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Anxiety ,Low-iodine diet ,Radioactive iodine ,Therapy ,Mobile application ,Satisfaction ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Hyperthyroidism and thyroid cancer significantly impact health, and often require Radioactive Iodine (RAI) therapy. Anxiety is common in patients undergoing RAI, particularly related to dietary compliance. This study aimed to assess the effectiveness of the mobile health application, DietLens in reducing anxiety and increasing satisfaction in patients preparing for RAI therapy, focusing on low-iodine diet (LID). A quasi-experimental study was conducted in a Singapore tertiary hospital outpatient department from March 13, 2019 to March 27, 2020, involving patients scheduled for their first RAI treatment. Participants were divided into a control group receiving standard care and an intervention group using DietLens alongside standard care. Anxiety levels were assessed using the Zung Self-Rating Anxiety Scale, and satisfaction levels were measured through self-reported questionnaires. In the study, 56 participants were initially divided into control (n = 28) and intervention (n = 28) groups. After accounting for dropouts, 50 participants finished the study, with each group comprising 25 individuals. Anxiety levels were similar between groups pre-intervention. Post-intervention, the intervention group displayed a significant decrease in anxiety levels compared to the control group (independent t-test: t (48) = 2.50, p = 0.02). The multivariate linear regression analysis indicated that being in the intervention group was significantly associated with a decrease in post-intervention anxiety score (β = −4.03, 95 % CI: −7.33 to −0.72, p = 0.02). Fisher's Exact Test revealed a borderline significant difference in satisfaction with educational materials and the overall treatment process, with 100 % of the intervention group expressing satisfaction compared to 80 % in the control group, resulting in a p-value of 0.052 in both instances. DietLens was effective in reducing anxiety and enhancing satisfaction related to RAI therapy preparation, particularly in managing a LID, highlighting a beneficial role for digital interventions in healthcare settings.
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- 2024
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131. Editorial: Artificial intelligence: new hope for critically ill cardiovascular patients
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Li-li Wu, Bo-ran Yang, Xin-yi Meng, Guan-wei Fan, and Bing Yang
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editorial ,artificial intelligence ,cardiovascular disorder ,critically ill patients ,cardiovascular medicine ,Medicine (General) ,R5-920 - Published
- 2024
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132. Intensive Versus Moderate Statin‐Based Therapies in Patients With Mild Ischemic Stroke: A Prospective Multicenter Cohort Study
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Hai‐mei Fan, Yong‐le Wang, Kai‐li Zhang, Ting‐ting Liu, Xin‐yi Li, Ya‐nan Li, Ya‐li Li, Juan Li, Jing Ren, Yu‐ting Liu, Jun‐hui Wang, Li‐xi Xue, Wen‐xian Du, Wen‐hua Niu, Yu‐ping Yan, Xiao‐lei Gao, Qing‐ping Liu, Gai‐mei Li, Xue‐mei Wu, and Xiao‐yuan Niu
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China ,follow‐up studies ,hydroxymethylglutaryl‐CoA reductase inhibitors ,intracranial hemorrhages ,ischemic stroke ,prospective studies ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Statins are widely used for treating patients with ischemic stroke at risk of secondary cerebrovascular events. It is unknown whether Asian populations benefit from more intensive statin‐based therapy for stroke recurrence. Therefore, in the present study we evaluated the effectiveness and safety of high‐dose and moderate‐dose statins for patients who had experienced mild ischemic stroke during the acute period. Methods and Results This multicenter prospective study included patients with mild ischemic stroke who presented within 72 hours of symptom onset. The outcomes of patients in the high‐intensity and moderate‐intensity statin treatment groups were compared, with the main efficacy outcome being stroke recurrence and the primary safety end point being intracranial hemorrhage. The propensity score matching method was employed to control for imbalances in baseline variables. Subgroup analyses were conducted to evaluate group differences. In total, the data of 2950 patients were analyzed at 3 months, and the data of 2764 patients were analyzed at 12 months due to loss to follow‐up. According to the multivariable Cox analyses adjusted for potential confounders, stroke recurrence occurred similarly in the high‐intensity statin and moderate‐intensity statin groups (3 months: adjusted hazard ratio [HR], 1.12 [95% CI, 0.85–1.49]; P=0.424; 12 months: adjusted HR, 1.08 [95% CI, 0.86–1.34]; P=0.519). High‐intensity statin therapy was associated with an increased risk of intracranial hemorrhage (3 months: adjusted HR, 1.81 [95% CI, 1.00–3.25]; P=0.048; 12 months: adjusted HR, 1.86 [95% CI, 1.10–3.16]; P=0.021). The results from the propensity score‐matched analyses were consistent with those from the Cox proportional hazards analysis. Conclusions Compared with moderate‐intensity statin therapy, high‐dose statin therapy may not decrease the risk of mild, noncardiogenic ischemic stroke recurrence but may increase the risk of intracranial hemorrhage. Registration URL: www.chictr.org.cn/. Unique Identifier: ChiCTR1900025214.
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- 2024
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133. Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression
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Xiao-Qiong Chen, Xuan Zhang, Ding-Guo Pan, Guo-Yu Li, Rui-Xi Hu, Tao Wu, Tao Shen, Xin-Yi Cai, Xian-Shuo Cheng, Junying Qin, Fu-Hui Xiao, and Yun-Feng Li
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Colon adenocarcinoma ,Ferroptosis ,Tumor immune microenvironment ,Transcriptome ,Neutrophil ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: Colon adenocarcinoma (COAD) is one of the most common malignant tumors. The interplay involving ferroptosis between tumor and immune cells plays a crucial in cancer progression. However, the biological basis of this interplay in COAD development remains elusive. Methods: Transcriptome data of COAD samples were obtained from The Cancer Genome Atlas and National Center for Biotechnology Information databases. Using single-sample gene set enrichment analysis, we calculated the ferroptosis score (FS) and immune cell infiltration levels for each sample, leveraging the expression levels of genes related to ferroptosis and various immune cell types. Samples with FSs greater than the 75th percentile were classified into the high-FS subgroup, while those below the 25th percentile were categorized as the low-FS subgroup. Moreover, tumor tissue samples and adjacent normal tissue samples were collected from twenty colon patients. Using real-time quantitative polymerase chain reaction, we validated the expression of certain genes in these samples. Results: The COAD samples with high FSs experienced favorable survival probability and heightened sensitivity to anticancer drugs, with FSs negatively associated with the pathological stages. Moreover, the up-regulated genes in high-FS subgroup exhibited enrichment in immune-related pathways, suggesting a correlation between immunity and ferroptosis. Importantly, we discovered a key lncRNA-mRNA co-expression network linking tumor cell ferroptosis and immune infiltration (e.g., neutrophil) in the progression and classification of COAD. Further analysis identified several ferroptosis-related lncRNAs (e.g., RP11-399O19.9) within this network, indicating their potential roles in COAD progression and deserving in-depth study. Conclusions: Our findings provide novel insights into the underlying biological basis, particularly involving lncRNAs, at gene expression level associated with ferroptosis in COAD and cancer therapy. Nevertheless, further analysis and validation are required to expand the findings.
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- 2024
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134. Sensitive fluorescence detection of miRNA-124 in cardiomyocytes under oxidative stress using a nucleic acid probe
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Shuo Li, Xiang-Yu Pei, Xin-Yi Liu, Shu-Liang Wang, Wen Xu, Jing-Jing Wang, Zhen Feng, Han Ding, Yin-Feng Zhang, and Rui Zhang
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Aptamer ,In situ detection ,miRNA-124 ,Oxidative ,Acute myocardial infarction ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
MicroRNAs (miRNAs) are small noncoding RNAs of 18–25 bases. miRNAs are also important new biomarkers that can be used for disease diagnosis in the future. Studies have shown that miR-124 levels are significantly elevated during acute myocardial infarction (AMI) and play a key role in the cardiovascular system. A variety of methods have been established to detect myocardial infarction-related miRNAs. However, most require complex miRNA extraction and isolation, and these methods are virtually undetectable when RNA levels are low in the sample. It may lead to biased results. Thus, it is necessary to develop a technique that can detect miRNA without extracting it, which means that intracellular detection is of great significance. Here, we improved the traditional silicon spheres and obtained a biosensor that could effectively capture and detect specific noncoding nucleic acids through the layer-by-layer assembly method. The sensor is protected by hyaluronic acid so it can successfully escape the lysosome into the cell and achieve detection. With the help of a full-featured microplate reader, we determined that the detection limit of the biosensor could reach 1 fM, meeting the needs of intracellular detection. At the same time, we prepared an oxidative stress cardiomyocyte infarction model and successfully captured the overexpressed miR-124 in the infarcted cells to achieve in situ detection. This study could provide a new potential tool to develop miRNAs for sensitive diagnosis in AMI, and the proposed strategy implies its potential for biomedical research.
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- 2024
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135. Mapping the gut microecological multi-omics signatures to serum metabolome and their impact on cardiometabolic health in elderly adultsResearch in context
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Chu-wen Ling, Kui Deng, Yingdi Yang, Hong-rou Lin, Chun-ying Liu, Bang-yan Li, Wei Hu, Xinxiu Liang, Hui Zhao, Xin-yi Tang, Ju-Sheng Zheng, and Yu-ming Chen
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Gut microbiota ,Metabolomics ,Proteomics ,Multi-omics ,Cardiometabolic health ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Mapping gut microecological features to serum metabolites (SMs) will help identify functional links between gut microbiome and cardiometabolic health. Methods: This study encompassed 836-1021 adults over 9.7 year in a cohort, assessing metabolic syndrome (MS), carotid atherosclerotic plaque (CAP), and other metadata triennially. We analyzed mid-term microbial metagenomics, targeted fecal and serum metabolomics, host genetics, and serum proteomics. Findings: Gut microbiota and metabolites (GMM) accounted for 15.1% overall variance in 168 SMs, with individual GMM factors explaining 5.65%–10.1%, host genetics 3.23%, and sociodemographic factors 5.95%. Specifically, GMM elucidated 5.5%–49.6% variance in the top 32 GMM-explained SMs. Each 20% increase in the 32 metabolite score (derived from the 32 SMs) correlated with 73% (95% confidence interval [CI]: 53%–95%) and 19% (95% CI: 11%–27%) increases in MS and CAP incidences, respectively. Among the 32 GMM-explained SMs, sebacic acid, indoleacetic acid, and eicosapentaenoic acid were linked to MS or CAP incidence. Serum proteomics revealed certain proteins, particularly the apolipoprotein family, mediated the relationship between GMM-SMs and cardiometabolic risks. Interpretation: This study reveals the significant influence of GMM on SM profiles and illustrates the intricate connections between GMM-explained SMs, serum proteins, and the incidence of MS and CAP, providing insights into the roles of gut dysbiosis in cardiometabolic health via regulating blood metabolites. Funding: This study was jointly supported by the National Natural Science Foundation of China, Key Research and Development Program of Guangzhou, 5010 Program for Clinical Research of Sun Yat-sen University, and the ‘Pioneer' and ‘Leading goose' R&D Program of Zhejiang.
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- 2024
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136. Cuproptosis in cancers: Function and implications from bench to bedside
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Xin-Yi Huang, Jia-Yang Shen, Ke Huang, Lingzhi Wang, Gautam Sethi, and Zhaowu Ma
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Cuproptosis ,Copper ,Copper chelator ,Copper ionophore ,Cancer therapy ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Copper, an indispensable micronutrient, is implicated in numerous vital biological processes and is essential for all physiological activities. Recently, the discovery of a novel type of copper-dependent cell death, known as cuproptosis, has shed light on its role in cancer development. Extensive research is currently underway to unravel the mechanisms underlying cuproptosis and its correlation with various cancer types. In this review, we summarize the findings regarding the roles and mechanisms of cuproptosis in various cancer types, including colorectal cancer, lung cancer, gastric cancer, breast cancer, liver cancer and cutaneous melanoma. Furthermore, the effects of copper-related agents such as copper chelators and copper ionophores on cell proliferation, apoptosis, angiogenesis, tumor immunity, and chemotherapy resistance have been explored in cancer preclinical and clinical trials. These insights provide promising avenues for the development of prospective anticancer drugs aimed at inducing cuproptosis.
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- 2024
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137. Developing environmental flows for the Baleh River : hydrological and geomorphological processes in the Baleh catchment prior to damming
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Chong, Xin Yi
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TD Environmental technology. Sanitary engineering - Abstract
Dams have been built in many parts of the world since the earliest human civilizations, but currently there is a significant program of dam building underway in the tropics. Despite general awareness of the likely detrimental impacts of dams, the limited number of empirical tropical studies means that specific effects of dams on these important but imperilled ecosystems are hard to predict. Although the Functional Flows (FFs) concept is now prominent in the scientific and river management literature, it has been applied only to some very specific cases in tropical areas to guide dam operation (e.g. to support periodic flooding of floodplain areas). In these and many other cases, FFs have been applied retrospectively, to design operational flows for existing dams. The work presented in this thesis concerns development of flow recommendations prior to the construction of a large tropical hydropower dam on Baleh River, Sarawak. Specific objectives of the thesis are to: (i) develop a full statistical understanding of the natural hydrological regime of Baleh River, (ii) identify critical habitat forming discharges (those responsible for coarse sediment entrainment and transport) and relations between discharge magnitude and hydraulic habitat heterogeneity, (iii) to assess the impact of the dam and other land use changes on sediment connectivity, and (iv) provide specific recommendations for dam operation to support sediment entrainment and maintenance of habitat heterogeneity, and for management of lake levels to limit changes in connectivity. The work involved analyses of historical data along with a number of empirical field data collection, modelling and remote sensing approaches. For Objective (i), a 51-year hydrological and hydro-climatological dataset was analysed in order to characterise the natural hydrological regime of the Baleh River. The analyses focussed on understanding the frequency, magnitude, duration, and timing of natural high and low flow events. For Objective (ii), HEC-RAS® models were built for 3 study reaches. These models were used to simulate hydraulic conditions across the range of discharges extending from high to low flows. The output from the hydraulic models was combined with information on critical entrainment thresholds of sediment at the 3 reaches in order to understand which flows are capable of entraining sediment. The focus of these analyses was to understand whether the expected hydropower regime is likely to cause sediment entrainment in the way that occurs currently under the natural regime. The analyses also used HEC-RAS® to evaluate hydraulic habitat heterogeneity at low flow conditions. The HEC-RAS® modelling was integrated with Soil and Water Assessment Tool (SWAT® or ArcSWAT®) to understand flow magnitude in the river under different conditions of hydropower operation and rainfall (which would lead to tributaries downstream from the dam discharging high flows to the mainstem Baleh). In addition, the model coupled with the DEMs was used to look at the extent of exposure of gravel bars during low flow conditions. The SedInConnect model was used to understand patterns of sediment connectivity across the Baleh catchment. This model computes the sediment connectivity index (IC). For the modelling, it was necessary to develop DEMs and collate information on landcover in order to calculate topographic roughness and IC. Information on sediment entrainment was used to make recommendations about flows needed to maintain the geomorphic processes (i.e. bedload transport) post-impoundment that occur currently in the natural river. The low flow analyses were used to understand whether hydraulic conditions became more or less heterogeneous at low flows. The hydrological analyses identified 5 distinct classes of high flow event in the Baleh (defined as 'Event Types'). These types have distinct magnitudes and durations. HEC-RAS® modelling indicated that the smallest of these events led to sediment entrainment of D16 and greater at the study sites, and that larger events resulted in increasing areas of the bed across the study reaches experiencing entrainment. The maximum likely hydropower releases are smaller in discharge magnitude than the smallest of these natural events. The modelling indicated that more or less no sediment entrainment would occur during normal hydropower operations. However, integration of the HEC-RAS® and ArcSWAT® models indicated that when the catchment is wet, tributaries are contributing enough flow to result in sediment entrainment at the study sites that equates to that under some of the higher natural event types. Hydraulic habitat heterogeneity was relatively high during low flows and dropped at moderate and high flows. Moreover, at low flows, gravel bars became exposed at some of the study sites adding to overall habitat heterogeneity. According to the IC models, the impact of historical landcover changes on connectivity between the Baleh and the Rajang has not been pronounced. However, the models predicted that future forest clearance and roads will have observable impacts on the connectivity between the Baleh and Rajang. The models indicated that the construction of the dam would result in a significant impact on connectivity, with the effects of impoundment being greater than those of road and landcover changes, leading to a large portion of the Baleh catchment being almost completely disconnected from the Rajang. The operation of the dam will affect IC upstream of the dam due to the changes in connectivity caused by different lake levels. The HEC-RAS® modelling suggested that over time, in the absence of significant bed entrainment and transport of material, the bed could be expected to become progressively armoured and coarser, as seen in dammed rivers worldwide. However, the modelling also indicated that when the catchment is wet and downstream tributaries are contributing much additional water, flows in the Baleh will greatly exceed turbine releases and appreciable entrainment of bed material can be expected. Recommendations for geomorphic functional flows are made on the basis of these findings. Recommendations are to ensure that hydropower releases using the maximum number of turbines are made during times when the catchment is already wet, to ensure entrainment of bed sediment. Based on analyses of the natural regime, the recommendations include suggestions for timing and duration of such releases. They should last around 20 days, occurring 8 to 15 times per year, predominantly during the wet season. Low flow recommendations were made to occasionally allow dam releases to drop to 1 to 3 turbines to mimic natural low flow events. The recommendation for these events was to allow flow to drop to the natural respective monthly baseflows; these flows should last around 3 days with a frequency of at least 3 times per month during the wet season, and 2 times per month during the dry season. The dam will disconnect a major part of the Baleh catchment from the Rajang. The modelling suggested that the effects of the dam on connectivity will swamp the effects of landcover change and road construction on connectivity. Nevertheless, localised impacts of the road were predicted by the model, with an increase in connectivity on the upslope areas. It is recommended that measures to mitigate this are implemented as part of road construction and management. The model suggested that careful management of lake levels could be used to reduce the impact of the dam on connectivity in the upper part of the basin. The study of functional flows presented in this thesis is of growing importance for sustainable catchment management, particularly in Southeast Asia, where rapid dam construction and vulnerability to the impacts of climate change are prevalent. It is one of few studies globally that has explicitly considered fluvial processes when developing functional flow recommendations. It is also novel in integrating reach scale HEC-RAS® models with catchment scale SWAT® models to help in the design of functional flow recommendations. As far as the author is aware, it is the only study globally to have used the SedInConnect model to understand the combined and interactive effects of damming, landcover change and road construction on structural connectivity at a catchment scale. These approaches can be applied to large rivers in Southeast Asia and other Global South regions, aiding sustainable catchment and water management. It is one of few functional flow studies to have been undertaken before dam closure, allowing us to implement functional recommendations in advance of construction, rather than retrofitting them to a river that has been regulated for some time. It is recommended that a program of monitoring is implemented in the Baleh in order to understand how the river changes in response to impoundment and the success of flow recommendations for maintaining sediment dynamics and habitat heterogeneity. This monitoring will provide the basis for adaptive management.
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- 2023
138. The α-core in a multi-objective game with set payoffs.
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Qi-Qing Song, Min Guo, and Xin-Yi Chi
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- 2024
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139. Strider: Signal Value Transition-Guided Defect Repair for HDL Programming Assignments.
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Deheng Yang, Jiayu He, Xiaoguang Mao, Tun Li, Yan Lei, Xin Yi, and Jiang Wu
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- 2024
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140. The EarSAVAS Dataset: Enabling Subject-Aware Vocal Activity Sensing on Earables.
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Xiyuxing Zhang, Yuntao Wang 0001, Yuxuan Han, Chen Liang, Ishan Chatterjee, Jiankai Tang, Xin Yi 0001, Shwetak N. Patel, and Yuanchun Shi
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- 2024
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141. HCI Research and Innovation in China: A 10-Year Perspective.
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Yuanchun Shi, Xin Yi 0001, Chen Liang, Yue Qin, Yuntao Wang 0001, Yukang Yan, Zhimin Cheng, Pengye Zhu, Shiyu Zhang, Yongjuan Li, Yanci Liu, Xuesong Wang, Jiawen Chen, Weixuan Zhou, Yifan Wang, Diya Zhao, and Feng Du
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- 2024
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142. Quantum Algorithm for Anomaly Detection of Sequences
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Guo, Ming-Chao, Liu, Hai-Ling, Pan, Shi-Jie, Li, Wen-Min, Qin, Su-Juan, Huang, Xin-Yi, Gao, Fei, and Wen, Qiao-Yan
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Quantum Physics - Abstract
Anomaly detection of sequences is a hot topic in data mining. Anomaly Detection using Piecewise Aggregate approximation in the Amplitude Domain (called ADPAAD) is one of the widely used methods in anomaly detection of sequences. The core step in the classical algorithm for performing ADPAAD is to construct an approximate representation of the subsequence, where the elements of each subsequence are divided into several subsections according to the amplitude domain and then the average of the subsections is computed. It is computationally expensive when processing large-scale sequences. In this paper, we propose a quantum algorithm for ADPAAD, which can divide the subsequence elements and compute the average in parallel. Our quantum algorithm can achieve polynomial speedups on the number of subsequences and the length of subsequences over its classical counterpart.
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- 2022
143. Extremely low mass ratio contact binaries -- I. the first photometric and spectroscopic investigations of ten systems
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Li, Kai, Gao, Xiang, Liu, Xin-Yi, Gao, Xing, Li, Ling-Zhi, Chen, Xu, and Sun, Guo-You
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The photometric and spectroscopic investigations of ten contact binaries were presented for the first time. It is discovered that the mass ratios of all the ten targets are smaller than 0.15, they are extremely low mass ratio contact binaries. Seven of them are deep contact binaries, two are medium contact binaries, while only one is a shallow contact system. Five of them show O'Connell effect, and a dark spot on one of the two components can lead to a good fit of the asymmetric light curves. The orbital period studies of the ten binaries reveal that they all exhibit long-term period changes, six of them are increasing, while the others are shrinking. The LAMOST spectra were analyzed by the spectral subtraction method, and all the ten targets exhibit excess emissions in the H$_\alpha$ line, indicating chromospheric activity. The evolutionary states of the two components of the ten binaries were studied, and it is found that their evolutionary states are identical to those of the other contact binaries. Based on the study of the relation between orbital angular momentum and total mass, we discovered the ten systems may be at the late evolutionary stage of a contact binary. The initial masses of the two components and the ages of them were obtained. By calculating the instability parameters, we found that the ten contact binaries are relatively stable at present., Comment: 19 pages, 8 figures,, and 9 tables, accepted by AJ
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- 2022
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144. Enabling Country-Scale Land Cover Mapping with Meter-Resolution Satellite Imagery
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Tong, Xin-Yi, Xia, Gui-Song, and Zhu, Xiao Xiang
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Computer Science - Computer Vision and Pattern Recognition - Abstract
High-resolution satellite images can provide abundant, detailed spatial information for land cover classification, which is particularly important for studying the complicated built environment. However, due to the complex land cover patterns, the costly training sample collections, and the severe distribution shifts of satellite imageries, few studies have applied high-resolution images to land cover mapping in detailed categories at large scale. To fill this gap, we present a large-scale land cover dataset, Five-Billion-Pixels. It contains more than 5 billion labeled pixels of 150 high-resolution Gaofen-2 (4 m) satellite images, annotated in a 24-category system covering artificial-constructed, agricultural, and natural classes. In addition, we propose a deep-learning-based unsupervised domain adaptation approach that can transfer classification models trained on labeled dataset (referred to as the source domain) to unlabeled data (referred to as the target domain) for large-scale land cover mapping. Specifically, we introduce an end-to-end Siamese network employing dynamic pseudo-label assignment and class balancing strategy to perform adaptive domain joint learning. To validate the generalizability of our dataset and the proposed approach across different sensors and different geographical regions, we carry out land cover mapping on five megacities in China and six cities in other five Asian countries severally using: PlanetScope (3 m), Gaofen-1 (8 m), and Sentinel-2 (10 m) satellite images. Over a total study area of 60,000 square kilometers, the experiments show promising results even though the input images are entirely unlabeled. The proposed approach, trained with the Five-Billion-Pixels dataset, enables high-quality and detailed land cover mapping across the whole country of China and some other Asian countries at meter-resolution.
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- 2022
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145. Lateral predictive coding revisited: Internal model, symmetry breaking, and response time
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Huang, Zhen-Ye, Fan, Xin-Yi, Zhou, Jianwen, and Zhou, Hai-Jun
- Subjects
Quantitative Biology - Neurons and Cognition ,Condensed Matter - Disordered Systems and Neural Networks ,Physics - Biological Physics - Abstract
Predictive coding is a promising theoretical framework in neuroscience for understanding information transmission and perception. It posits that the brain perceives the external world through internal models and updates these models under the guidance of prediction errors. Previous studies on predictive coding emphasized top-down feedback interactions in hierarchical multi-layered networks but largely ignored lateral recurrent interactions. We perform analytical and numerical investigations in this work on the effects of single-layer lateral interactions. We consider a simple predictive response dynamics and run it on the MNIST dataset of hand-written digits. We find that learning will generally break the interaction symmetry between peer neurons, and that high input correlation between two neurons does not necessarily bring strong direct interactions between them. The optimized network responds to familiar input signals much faster than to novel or random inputs, and it significantly reduces the correlations between the output states of pairs of neurons., Comment: 12 pages, including 10 figures. To be published in the journal CTP
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- 2022
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146. Letter to the Editor: “How shoulder immobilization after surgery influences daily activity — a prospective pedometer‐based study”
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Liu, Fei and Gong, Xin-yi
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- 2024
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147. Prediction of Tumor Microenvironment Characteristics and Treatment Response in Lung Squamous Cell Carcinoma by Pseudogene OR7E47P-related Immune Genes
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Zhao, Ya-qi, Zhang, Hao-han, Wu, Jie, Li, Lan, Li, Jing, Zhong, Hao, Jin, Yan, Lei, Tian-yu, Zhao, Xin-yi, Xu, Bin, Song, Qi-bin, and He, Jie
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- 2023
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148. Effective Model Compression via Stage-wise Pruning
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Zhang, Ming-Yang, Yu, Xin-Yi, and Ou, Lin-Lin
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- 2023
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149. Using a CT-based scale to evaluate disease extension and the resectability of locally advanced thyroid cancer
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Huang, Nai-si, Li, Qiao, Gao, Xin-Yi, Xiang, Shi-yu, Ji, Qing-hai, Xiang, Jun, Wang, Yu-long, Wei, Wen-jun, Chen, Jia-ying, Yu, Qing, Cao, Yi-ming, Guan, Qing, Gu, Ya-jia, and Wang, Yu
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- 2023
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150. Tungsten doping La0.6Ca0.4Fe0.8Ni0.2O3−δ as electrode for highly efficient and stable symmetric solid oxide cells
- Author
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Jiao, Xin-Yi, Geng, Ao-Yan, Xue, Yi-Yang, Wang, Xing-Bao, Jin, Fang-Jun, Ling, Yi-Han, and Tian, Yun-Feng
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- 2023
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