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117. Living Low: Alternative Housing and Life in Guangzhou Villages-by-the-City

Author

Wu, Jiong

Subjects
Architecture
Abstract

Among the numerous questions about China’s ongoing transformations, a crucial one is: how did ninety million peasants transform themselves into new social subjects in the reform era? This research responds to this general inquiry by identifying housing in “villages-by-the-city” (城边村) as a key spatial arena in making what I call “post-peasantry subjects”. In doing so, it criticizes two main bodies of literature in China Studies by filling in two of their lacuna. It foregrounds village housing as a key, yet largely overlooked analytical site for peasantry research; and it adds an under-investigated locale, “villages-by-the city” to housing studies.This dissertation provides an architectural ethnography of the housing practices in Guangzhou villages-by-the-city. While focusing on Guangzhou, it notes broader social and housing trends in contemporary China. It draws on extensive documentations and ethnographic fieldwork. I examine the roles of housing design, construction, management, and consumption in re-configuring village domestic spaces, lifestyles, and village organizations from 1978 to 2017. Through their housing practices, they empowered and reinvented themselves as a broad spectrum of post-peasantry subjects, such as urban villager, peasant-worker master, village middle class, etc. In highlighting their housing creativity, I argue that the village inhabitants have produced a form of spatial agency—what I call “housing agency”—in reaction to the limits of their social and political conditions and to achieve self-reinvention, which is both productive yet contested. This dissertation comprehensively documents, for the first time, the transformation and creativity of the Chinese rural population in their housing practices and building cultures. While pointing out limits and controversies, it also shows the abundant possibilities and opportunities in the village-by-the-city habitation. Thus, it is also an attempt to both question and offer alternatives to the large-scale developer-produced xiaoqu (gated community) housing that dominates contemporary China.

Published
2020

124. MNX1 Promotes Anti-HER2 Therapy Sensitivity via Transcriptional Regulation of CD-M6PR in HER2-Positive Breast Cancer.

Author

Chi, Weiru, Xiu, Bingqiu, Xiong, Min, Wang, Xuliren, Li, Pei, Zhang, Qi, Hou, Jianjing, Sang, Yuting, Zhou, Xujie, Chen, Ming, Zheng, Shuyue, Zhang, Liyi, Xue, Jingyan, Chi, Yayun, and Wu, Jiong

Subjects
HER2 positive breast cancer, EPIDERMAL growth factor receptors, GENETIC transcription regulation, PACLITAXEL, BREAST, CORE needle biopsy, HOMEOBOX genes, TISSUE arrays, PROGNOSIS
Abstract

Although targeted therapy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer has significantly prolonged survival time and improved patients' quality of life, drug resistance has gradually emerged. This study explored the mechanisms underlying the effect of the motor neuron and pancreatic homeobox 1 (MNX1) genes on drug sensitivity in HER2-positive breast cancer. From July 2017 to 2018, core needle biopsies of HER2-positive breast cancer were collected from patients who received paclitaxel, carboplatin, and trastuzumab neoadjuvant therapy at our center. Based on treatment efficacy, 81 patients were divided into pathological complete response (pCR) and non-pCR groups. High-throughput RNA sequencing results were analyzed along with the GSE181574 dataset. MNX1 was significantly upregulated in the pCR group compared with the non-pCR group in both sequencing datasets, suggesting that MNX1 might be correlated with drug sensitivity in HER2-positive breast cancer. Meanwhile, tissue array results revealed that high MNX1 expression corresponded to a good prognosis. In vitro functional tests showed that upregulation of MNX1 significantly increased the sensitivity of HER2-positive breast cancer cells to lapatinib and pyrotinib. In conclusion, MNX1 may serve as a prognostic marker for patients with HER2-positive breast cancer, and its expression may facilitate clinical screening of patients sensitive to anti-HER2-targeted therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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125. A prospective comparison of a modified miniaturised hand‐held epifluorescence microscope and touch imprint cytology for evaluation of axillary sentinel lymph nodes intraoperatively in breast cancer patients.

Author

Chen, Jia‐jian, Yu, Bao‐hua, Shen, Ti‐jing, Wang, Ying, Ren, Fei, Yang, Li‐rui, Dong, Yuan, Zheng, Ming‐jie, Hao, Shuang, Yang, Wen‐tao, and Wu, Jiong

Subjects
SENTINEL lymph nodes, BREAST cancer, CANCER patients, CYTOLOGY, MICROSCOPES
Abstract

Background: The management of axillary lymph nodes in early‐stage breast cancer patients has changed considerably, with the primary focus shifting from the examination of sentinel lymph nodes (SLNs) to toward the detection of all macro‐metastases. However, current methods, such as touch imprint cytology (TIC) and frozen sections, are inadequate for clinical needs. To address this issue, we proposed a novel miniaturised epifluorescence widefield microscope (MEW‐M) to assess SLN status intraoperatively for improved diagnostic efficiency. Methods: A prospective, side‐by‐side comparison of intraoperative SLN evaluation between MEW‐M and TIC was performed. Results: A total of 73 patients with 319 SLNs consecutive enrolled in this study. MEW‐M showed significantly superior image quality compared to TIC (median score 3.1 vs 2.1, p < 0.0001) and had a shorter time to issue results (10.3 vs 19.4 min, p < 0.0001). Likelihood ratio analysis illustrated that the positive likelihood ratio value of MEW‐M compared with TIC was infinitely great vs 52.37 (95% CI, 21.96‐124.90) in model 1 (classifying results into negative/positive), infinitely great vs 52.37 (95% CI, 21.96‐124.90) in model 2 (classifying results into macro‐metastasis/others, and TIC results followed the same classification as model 1), respectively. Similarly, the negative likelihood ratio values of MEW‐M compared with TIC were 0.055 (95% CI, 0.018‐0.160) and 0.074 (95% CI, 0.029‐0.190) in model 1; and 0.019 (95% CI, 0.003‐0.130) vs 0.020 (95% CI, 0.003‐0.140) in model 2, respectively. Conclusions: MEW‐M is a promising technique that can be utilised to provide a rapid and accurate intraoperative assessment of SLN in a clinical setting to help improve decision‐making in axillary surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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134. Physical Environments of the Luminosity Outburst Source NGC 6334I Traced by Thermal and Maser Lines of Multiple Molecules

Author

Wu, Jiong-Heng, primary, Chen, Xi, additional, Zhang, Yan-Kun, additional, Ellingsen, Simon P., additional, Sobolev, Andrej M., additional, Zhao, Zhang, additional, Song, Shi-Ming, additional, Shen, Zhi-Qiang, additional, Li, Bin, additional, Xia, Bo, additional, Zhao, Rong-Bin, additional, Wang, Jing-Qing, additional, and Wu, Ya-Jun, additional

Published
2023
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136. Supplementary tables and figures from Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma

Author

Guo, Wei, primary, Sun, Yun-Fan, primary, Shen, Min-Na, primary, Ma, Xiao-Lu, primary, Wu, Jiong, primary, Zhang, Chun-Yan, primary, Zhou, Yan, primary, Xu, Yang, primary, Hu, Bo, primary, Zhang, Min, primary, Wang, Gang, primary, Chen, Wei-Qin, primary, Guo, Lin, primary, Lu, Ren-Quan, primary, Zhou, Chao-Hui, primary, Zhang, Xin, primary, Shi, Ying-Hong, primary, Qiu, Shuang-jian, primary, Pan, Bai-shen, primary, Cao, Ya, primary, Zhou, Jian, primary, Yang, Xin-Rong, primary, and Fan, Jia, primary

Published
2023
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137. Supplementary Data from Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer

Author

Yu, Jian, primary, Kane, Susan, primary, Wu, Jiong, primary, Benedettini, Elisa, primary, Li, Daiqiang, primary, Reeves, Cynthia, primary, Innocenti, Gregory, primary, Wetzel, Randy, primary, Crosby, Katherine, primary, Becker, Alison, primary, Ferrante, Michelle, primary, Cheung, Wan Cheung, primary, Hong, Xiqiang, primary, Chirieac, Lucian R., primary, Sholl, Lynette M., primary, Haack, Herbert, primary, Smith, Bradley L., primary, Polakiewicz, Roberto D., primary, Tan, Yi, primary, Gu, Ting-Lei, primary, Loda, Massimo, primary, Zhou, Xinmin, primary, and Comb, Michael J., primary

Published
2023
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141. Supplementary Figure from Famitinib with Camrelizumab and Nab-Paclitaxel for Advanced Immunomodulatory Triple-Negative Breast Cancer (FUTURE-C-Plus): An Open-Label, Single-Arm, Phase II Trial

Author

Chen, Li, primary, Jiang, Yi-Zhou, primary, Wu, Song-Yang, primary, Wu, Jiong, primary, Di, Gen-Hong, primary, Liu, Guang-Yu, primary, Yu, Ke-Da, primary, Fan, Lei, primary, Li, Jun-Jie, primary, Hou, Yi-Feng, primary, Hu, Zhen, primary, Chen, Can-Ming, primary, Huang, Xiao-Yan, primary, Cao, A-Yong, primary, Hu, Xin, primary, Zhao, Shen, primary, Ma, Xiao-Yan, primary, Xu, Ying, primary, Sun, Xiang-Jie, primary, Chai, Wen-Jun, primary, Guo, Xiaomao, primary, Chen, Xizi, primary, Xu, Yanhui, primary, Zhu, Xiao-Yu, primary, Zou, Jian-Jun, primary, Yang, Wen-Tao, primary, Wang, Zhong-Hua, primary, and Shao, Zhi-Ming, primary

Published
2023
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148. Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Tables 1 through 5 from SSBP1 Suppresses TGFβ-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling

Author

Jiang, Hong-Lin, primary, Sun, He-Fen, primary, Gao, Shui-Ping, primary, Li, Liang-Dong, primary, Huang, Sheng, primary, Hu, Xin, primary, Liu, Sheng, primary, Wu, Jiong, primary, Shao, Zhi-Ming, primary, and Jin, Wei, primary

Published
2023
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