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1,132 results on '"Wong, Wilson"'

101. Determining the Unithood of Word Sequences using a Probabilistic Approach

Author

Wong, Wilson, Liu, Wei, and Bennamoun, Mohammed

Subjects
Computer Science - Artificial Intelligence
Abstract

Most research related to unithood were conducted as part of a larger effort for the determination of termhood. Consequently, novelties are rare in this small sub-field of term extraction. In addition, existing work were mostly empirically motivated and derived. We propose a new probabilistically-derived measure, independent of any influences of termhood, that provides dedicated measures to gather linguistic evidence from parsed text and statistical evidence from Google search engine for the measurement of unithood. Our comparative study using 1,825 test cases against an existing empirically-derived function revealed an improvement in terms of precision, recall and accuracy., Comment: More information is available at http://explorer.csse.uwa.edu.au/reference/

Published
2008

102. Practical Approach to Knowledge-based Question Answering with Natural Language Understanding and Advanced Reasoning

Author

Wong, Wilson

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, Computer Science - Human-Computer Interaction, Computer Science - Information Retrieval, I.2.7, H.5.2, H.3.4, H.3.3
Abstract

This research hypothesized that a practical approach in the form of a solution framework known as Natural Language Understanding and Reasoning for Intelligence (NaLURI), which combines full-discourse natural language understanding, powerful representation formalism capable of exploiting ontological information and reasoning approach with advanced features, will solve the following problems without compromising practicality factors: 1) restriction on the nature of question and response, and 2) limitation to scale across domains and to real-life natural language text., Comment: Master of Science thesis, National Technical University College of Malaysia, 2005

Published
2007

104. Dressed to Kill, and Having a Weekend-Long Ball

Author

Wong, Wilson

Subjects
Music festivals -- Appreciation, Fashion -- Influence, Music fans -- Beliefs, opinions and attitudes -- Clothing, General interest, News, opinion and commentary
Abstract

Neither a drop of rain nor a cloud of wildfire smoke could keep more than 100,000 fans from flocking to the Governors Ball Music Festival over the weekend at Flushing [...]

Published
2023

105. The Funky, Slinky Fashion From This Year’s Governors Ball

Author

Wong, Wilson

Subjects
Music festivals, Wildfires, News, opinion and commentary
Abstract

Neither a drop of rain nor a cloud of wildfire smoke could keep more than 100,000 fans from flocking to the Governors Ball Music Festival over the weekend at Flushing [...]

Published
2023

106. On 'The Idol,' She Steals the Show

Author

Wong, Wilson

Subjects
The Idol (Television program) -- Appreciation, Pop singers -- Appreciation, General interest, News, opinion and commentary, Blackpink (Music group) -- Officials and employees
Abstract

Fans of the K-pop group are tuning in to the new HBO series to marvel at the global pop star in her acting debut. Before airing on HBO, the drama [...]

Published
2023

109. Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

Author

Wong, Wilson, Huang, Rick, Menant, Sebastien, Hong, Chuan, Sandow, Jarrod J., Birkinshaw, Richard W., Healer, Julie, Hodder, Anthony N., Kanjee, Usheer, Tonkin, Christopher J., Heckmann, Denise, Soroka, Vladislav, Søgaard, Teit Max Moscote, Jørgensen, Thomas, Duraisingh, Manoj T., Czabotar, Peter E., de Jongh, Willem A., Tham, Wai-Hong, Webb, Andrew I., Yu, Zhiheng, and Cowman, Alan F.

Published
2019
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110. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.

Author

Wei, Ping, Wong, Wilson, Park, Jason, Corcoran, Ethan, Peisajovich, Sergio, Onuffer, James, Weiss, Arthur, and Lim, Wendell

Subjects
Bacterial Outer Membrane Proteins, Bacterial Proteins, Biotechnology, Cell Proliferation, Cells, Cultured, Feedback, Physiological, Genetic Engineering, Humans, Interleukin-2, Jurkat Cells, Lymphocyte Activation, MAP Kinase Signaling System, Osmolar Concentration, Protein Tyrosine Phosphatases, Saccharomyces cerevisiae, Shigella flexneri, T-Lymphocytes, Virulence Factors, Yersinia pestis
Abstract

Bacterial pathogens have evolved specific effector proteins that, by interfacing with host kinase signalling pathways, provide a mechanism to evade immune responses during infection. Although these effectors contribute to pathogen virulence, we realized that they might also serve as valuable synthetic biology reagents for engineering cellular behaviour. Here we exploit two effector proteins, the Shigella flexneri OspF protein and Yersinia pestis YopH protein, to rewire kinase-mediated responses systematically both in yeast and mammalian immune cells. Bacterial effector proteins can be directed to inhibit specific mitogen-activated protein kinase pathways selectively in yeast by artificially targeting them to pathway-specific complexes. Moreover, we show that unique properties of the effectors generate new pathway behaviours: OspF, which irreversibly inactivates mitogen-activated protein kinases, was used to construct a synthetic feedback circuit that shows novel frequency-dependent input filtering. Finally, we show that effectors can be used in T cells, either as feedback modulators to tune the T-cell response amplitude precisely, or as an inducible pause switch that can temporarily disable T-cell activation. These studies demonstrate how pathogens could provide a rich toolkit of parts to engineer cells for therapeutic or biotechnological applications.

Published
2012

113. Korean Waves Whet an Appetite for Curls

Author

Wong, Wilson

Subjects
Personal appearance -- Forecasts and trends, Hairstyles -- Forecasts and trends, Market trend/market analysis, News, opinion and commentary, General interest
Abstract

The modern men's perm is loud for a hairstyle so soft. On TikTok, the hashtag #menperm, referring to one of the latest hair trends to be born from the app, [...]

Published
2023

114. A Coronation F.A.Q

Author

Alexander, Charanna, Friedman, Vanessa, Garcia, Sandra E., Grillo, Emma, Holtermann, Callie, Lee, Anna Grace, Lucero II, Louis, O’Neill, Shane, Paton, Elizabeth, Rotunno, Anthony, Solis, Marie, Vadukul, Alex, and Wong, Wilson

Subjects
News, opinion and commentary
Abstract

What is a coronation? A coronation can refer to both the literal act of placing a crown on a monarch’s head as well as the religious ceremony during which a [...]

Published
2023

115. Think You Know How ‘Succession’ Ends? Want to Bet?

Author

Wong, Wilson

Subjects
Television programs, News, opinion and commentary
Abstract

Viewers of the popular HBO drama are placing friendly wagers on who will succeed the media mogul Logan Roy. Buy-ins can go up to $200. Who will succeed the media [...]

Published
2023

116. ‘Vanderpump Rules’ Affair: Everything You Need to Know

Author

Wong, Wilson

Subjects
Reality television programs, Scandals, News, opinion and commentary
Abstract

A cheating scandal involving the cast members of a Bravo reality television show took the internet by storm. It was the cheating scandal that broke the internet: Tom Sandoval and [...]

Published
2023

134. The sound of silence: Transgene silencing in mammalian cell engineering

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Cabrera, Alan, Edelstein, Hailey I, Glykofrydis, Fokion, Love, Kasey S, Palacios, Sebastian, Tycko, Josh, Zhang, Meng, Lensch, Sarah, Shields, Cara E, Livingston, Mark, Weiss, Ron, Zhao, Huimin, Haynes, Karmella A, Morsut, Leonardo, Chen, Yvonne Y, Khalil, Ahmad S, Wong, Wilson W, Collins, James J, Rosser, Susan J, Polizzi, Karen, Elowitz, Michael B, Fussenegger, Martin, Hilton, Isaac B, Leonard, Joshua N, Bintu, Lacramioara, Galloway, Kate E, Deans, Tara L, Massachusetts Institute of Technology. Department of Biological Engineering, Cabrera, Alan, Edelstein, Hailey I, Glykofrydis, Fokion, Love, Kasey S, Palacios, Sebastian, Tycko, Josh, Zhang, Meng, Lensch, Sarah, Shields, Cara E, Livingston, Mark, Weiss, Ron, Zhao, Huimin, Haynes, Karmella A, Morsut, Leonardo, Chen, Yvonne Y, Khalil, Ahmad S, Wong, Wilson W, Collins, James J, Rosser, Susan J, Polizzi, Karen, Elowitz, Michael B, Fussenegger, Martin, Hilton, Isaac B, Leonard, Joshua N, Bintu, Lacramioara, Galloway, Kate E, and Deans, Tara L

Abstract

To elucidate principles operating in native biological systems and to develop novel biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within native transcriptional networks. The utility of synthetic gene circuits for cell engineering relies on the ability to control the expression of all constituent transgene components. Transgene silencing, defined as the loss of expression over time, persists as an obstacle for engineering primary cells and stem cells with transgenic cargos. In this review, we highlight the challenge that transgene silencing poses to the robust engineering of mammalian cells, outline potential molecular mechanisms of silencing, and present approaches for preventing transgene silencing. We conclude with a perspective identifying future research directions for improving the performance of synthetic gene circuits.

Published
2023

139. Competing perspectives on the Big Data revolution: a typology of applications in public policy.

Author

Wong, Wilson and C. Hinnant, Charles

Subjects
*BIG data, *GOVERNMENT policy, *DISRUPTIVE innovations, *SMART cities
Abstract

While the Big Data revolution is transforming public policy, some debates and competing perspectives on the impact of the disruptive technology of Big Data analytics remain. Although trade-offs among objectives are inevitable in Big Data applications, its ultimate impact would depend on the moderating factors, which vary across contexts such as policy areas and national systems. Integrating the literature from multiple disciplines, this article identifies some of the critical moderating factors accounting for the differentials of Big Data impacts and develops a typology of its applications in public policy as a heuristic to understand and reconcile competing perspectives. [ABSTRACT FROM AUTHOR]

Published
2023
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144. The sound of silence: Transgene silencing in mammalian cell engineering

Author

Cabrera, Alan, primary, Edelstein, Hailey I., additional, Glykofrydis, Fokion, additional, Love, Kasey S., additional, Palacios, Sebastian, additional, Tycko, Josh, additional, Zhang, Meng, additional, Lensch, Sarah, additional, Shields, Cara E., additional, Livingston, Mark, additional, Weiss, Ron, additional, Zhao, Huimin, additional, Haynes, Karmella A., additional, Morsut, Leonardo, additional, Chen, Yvonne Y., additional, Khalil, Ahmad S., additional, Wong, Wilson W., additional, Collins, James J., additional, Rosser, Susan J., additional, Polizzi, Karen, additional, Elowitz, Michael B., additional, Fussenegger, Martin, additional, Hilton, Isaac B., additional, Leonard, Joshua N., additional, Bintu, Lacramioara, additional, Galloway, Kate E., additional, and Deans, Tara L., additional

Published
2022
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147. Senti-202, a Selective, Off-the-Shelf, Preclinical CAR-NK Cell Therapy with CD33 and/or FLT3 Activating CAR, Healthy Cell Protection from Endomucin (EMCN) Inhibitory CAR and Calibrated Release IL-15 for Hematologic Malignancies Including AML

Author

Garrison, Brian, primary, Deng, Han, additional, Yucel, Gozde, additional, Frankel, Nicholas W., additional, Gordley, Russell, additional, Hung, Michelle, additional, Lee, Derrick, additional, Gainer, Marcus, additional, Roguev, Assen, additional, Gorman, Wesley, additional, Leemans, Nelia, additional, Lam, Alice, additional, Li, Yongshuai, additional, Wong, Wilson, additional, Rajangam, Kanya L., additional, Lee, Philip, additional, and Lu, Tim, additional

Published
2022
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