3,865 results on '"Wilson, P. L."'
Search Results
102. Prediction of stent under-expansion in calcified coronary arteries using machine learning on intravascular optical coherence tomography images
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Gharaibeh, Yazan, Lee, Juhwan, Zimin, Vladislav N., Kolluru, Chaitanya, Dallan, Luis A. P., Pereira, Gabriel T. R., Vergara-Martel, Armando, Kim, Justin N., Hoori, Ammar, Dong, Pengfei, Gamage, Peshala T., Gu, Linxia, Bezerra, Hiram G., Al-Kindi, Sadeer, and Wilson, David L.
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- 2023
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103. Load-sharing characteristics of stenting and post-dilation in heavily calcified coronary artery
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Dong, Pengfei, Colmenarez, Jose, Lee, Juhwan, Hassani, Neda Shafiabadi, Wilson, David L., Bezerra, Hiram G., and Gu, Linxia
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- 2023
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104. A generalizable Cas9/sgRNA prediction model using machine transfer learning with small high-quality datasets
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Ham, Dalton T., Browne, Tyler S., Banglorewala, Pooja N., Wilson, Tyler L., Michael, Richard K., Gloor, Gregory B., and Edgell, David R.
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- 2023
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105. Barriers to accessing malaria treatment amongst school-age children in rural Malawi
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Mhango, Patani, Malata, Monica Patricia, Chipeta, Effie, Sixpence, Alick, Taylor, Terrie E., Wilson, Mark L., Cohee, Lauren M., Mangani, Charles, and Mathanga, Don P.
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- 2023
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106. Transport pathways and kinetics of cerebrospinal fluid tracers in mouse brain observed by dynamic contrast-enhanced MRI
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Zhu, Yuran, Wang, Guanhua, Kolluru, Chaitanya, Gu, Yuning, Gao, Huiyun, Zhang, Jing, Wang, Yunmei, Wilson, David L., Zhu, Xiaofeng, Flask, Chris A., and Yu, Xin
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- 2023
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107. Optimal slice thickness for improved accuracy of quantitative analysis of fluorescent cell and microsphere distribution in cryo-images
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Wuttisarnwattana, Patiwet, Eck, Brendan L., Gargesha, Madhusudhana, and Wilson, David L.
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- 2023
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108. Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for human-to-mosquito Plasmodium falciparum transmission
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Mbewe, Rex B., Keven, John B., Mangani, Charles, Wilson, Mark L., Mzilahowa, Themba, Mathanga, Don P., Valim, Clarissa, Laufer, Miriam K., Walker, Edward D., and Cohee, Lauren M.
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- 2023
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109. Assessment of the therapeutic role of mesenchymal stromal cells in a mouse model of graft-versus-host disease using cryo-imaging
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Wuttisarnwattana, Patiwet, Eid, Saada, Wilson, David L., and Cooke, Kenneth R.
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- 2023
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110. Author Correction: Assessment of the therapeutic role of mesenchymal stromal cells in a mouse model of graft-versus-host disease using cryo-imaging
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Wuttisarnwattana, Patiwet, Eid, Saada, Wilson, David L., and Cooke, Kenneth R.
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- 2023
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111. Controlling astrocyte-mediated synaptic pruning signals for schizophrenia drug repurposing with deep graph networks
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Gravina, Alessio, Wilson, Jennifer L, Bacciu, Davide, Grimes, Kevin J, and Priami, Corrado
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Information and Computing Sciences ,Medicinal and Biomolecular Chemistry ,Chemical Sciences ,Schizophrenia ,Brain Disorders ,Mental Health ,Neurosciences ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Mental health ,Good Health and Well Being ,Astrocytes ,Drug Repositioning ,Humans ,Machine Learning ,Neuronal Plasticity ,Mathematical Sciences ,Biological Sciences ,Bioinformatics - Abstract
Schizophrenia is a debilitating psychiatric disorder, leading to both physical and social morbidity. Worldwide 1% of the population is struggling with the disease, with 100,000 new cases annually only in the United States. Despite its importance, the goal of finding effective treatments for schizophrenia remains a challenging task, and previous work conducted expensive large-scale phenotypic screens. This work investigates the benefits of Machine Learning for graphs to optimize drug phenotypic screens and predict compounds that mitigate abnormal brain reduction induced by excessive glial phagocytic activity in schizophrenia subjects. Given a compound and its concentration as input, we propose a method that predicts a score associated with three possible compound effects, i.e., reduce, increase, or not influence phagocytosis. We leverage a high-throughput screening to prove experimentally that our method achieves good generalization capabilities. The screening involves 2218 compounds at five different concentrations. Then, we analyze the usability of our approach in a practical setting, i.e., prioritizing the selection of compounds in the SWEETLEAD library. We provide a list of 64 compounds from the library that have the most potential clinical utility for glial phagocytosis mitigation. Lastly, we propose a novel approach to computationally validate their utility as possible therapies for schizophrenia.
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- 2022
112. From random to predictive: a context-specific interaction framework improves selection of drug protein-protein interactions for unknown drug pathways.
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Wilson, Jennifer L, Gravina, Alessio, and Grimes, Kevin
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Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Algorithms ,Biophysical Phenomena ,Computational Biology ,Phenotype ,Protein Interaction Maps ,Proteins ,drug pathways ,protein network modeling ,side effect prediction ,Medicinal and Biomolecular Chemistry ,Biochemistry and Cell Biology ,Pharmacology and Pharmaceutical Sciences ,General Science & Technology - Abstract
With high drug attrition, protein-protein interaction (PPI) network models are attractive as efficient methods for predicting drug outcomes by analyzing proteins downstream of drug targets. Unfortunately, these methods tend to overpredict associations and they have low precision and prediction performance; performance is often no better than random (AUROC ~0.5). Typically, PPI models identify ranked phenotypes associated with downstream proteins, yet methods differ in prioritization of downstream proteins. Most methods apply global approaches for assessing all phenotypes. We hypothesized that a per-phenotype analysis could improve prediction performance. We compared two global approaches-statistical and distance-based-and our novel per-phenotype approach, 'context-specific interaction' (CSI) analysis, on severe side effect prediction. We used a novel dataset of adverse events (or designated medical events, DMEs) and discovered that CSI had a 50% improvement over global approaches (AUROC 0.77 compared to 0.51), and a 76-95% improvement in average precision (0.499 compared to 0.284, 0.256). Our results provide a quantitative rationale for considering downstream proteins on a per-phenotype basis when using PPI network methods to predict drug phenotypes.
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- 2022
113. Correction: Integrated Aedes management for the control of Aedes-borne diseases
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Roiz, David, Wilson, Anne L, Scott, Thomas W, Fonseca, Dina M, Jourdain, Frédéric, Müller, Pie, Velayudhan, Raman, and Corbel, Vincent
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Biological Sciences ,Biomedical and Clinical Sciences ,Health Sciences ,Good Health and Well Being ,Medical and Health Sciences ,Tropical Medicine ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
[This corrects the article DOI: 10.1371/journal.pntd.0006845.].
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- 2022
114. An augmented Lagrangian algorithm for recovery of ice thickness in unidirectional flow using the Shallow Ice Approximation
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McGeorge, Elizabeth K., Moyers-Gonzalez, Miguel, Sellier, Mathieu, and Wilson, Phillip L.
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Physics - Atmospheric and Oceanic Physics ,Mathematics - Optimization and Control ,Physics - Computational Physics ,Physics - Fluid Dynamics ,Physics - Geophysics - Abstract
A key parameter in ice flow modelling is basal slipping at the ice-bed interface as it can have a large effect on the resultant ice thickness. Unfortunately, its contribution to surface observations can be hard to distinguish from that of bed undulations. Therefore, inferring the ice thickness from surface measurements is an interesting and non-trivial inverse problem. This paper presents a method for recovering dually the ice thickness and the basal slip using only surface elevation and speed measurements. The unidirectional shallow ice approximation is first implemented to model steady state ice flow for given bedrock and basal slip profiles. This surface is then taken as synthetic observed data. An augmented Lagrangian algorithm is then used to find the diffusion coefficient which gives the best fit to observations. Combining this recovered diffusion with observed surface velocity, a simple Newton's method is used to recover both the ice thickness and basal slip. The method was successful in each test case and this implies that it should be possible to recover both of these parameters in two-dimensional cases also.
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- 2021
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115. Truth Hidden in Plain Sight: How Social-Emotional Learning Empowers Novice Teachers' Culturally Responsive Pedagogy in Title I Schools
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Michalec, Paul and Wilson, Jodie L.
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Educational inequity for students in highly impacted urban schools in the United States remains a persistent challenge despite efforts to reshape teaching practices. This article argues for the inclusion of holistic qualities of novice teacher effectiveness, including how the social and emotional learning (SEL) of teachers contributes to the development of critically informed pedagogies for teaching culturally and linguistically diverse students. Using data from 21 interviews with novice teachers, mentor teachers, instructional coaches, and school leaders, we argue that the skills and dispositions for student SEL can be used to inform understanding and implementation of culturally responsive pedagogy for novice teachers.
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- 2022
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116. Cellular Therapy for Children with Central Nervous System Tumors: Mining and Mapping the Correlative Data
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Crotty, Erin E., Wilson, Ashley L., Davidson, Tom, Tahiri, Sophia, Gust, Juliane, Griesinger, Andrea M., Venkataraman, Sujatha, Park, Julie R., Mueller, Sabine, Rood, Brian R., Hwang, Eugene I., Wang, Leo D., and Vitanza, Nicholas A.
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- 2023
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117. Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer Survivors (The AIM Trial): Rationale, Design, and Methods
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Kang, Dong-Woo, Wilson, Rebekah L, Gonzalo-Encabo, Paola, Norris, Mary K, Hans, Marybeth, Tahbaz, Meghan, Dawson, Jackie, Nguyen, Danny, Normann, Amber J, Yunker, Alexandra G, Sami, Nathalie, Uno, Hajime, Ligibel, Jennifer A, Mittelman, Steven D, and Dieli-Conwright, Christina M
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Breast Cancer ,Physical Rehabilitation ,Rehabilitation ,Prevention ,Clinical Research ,Nutrition ,Clinical Trials and Supportive Activities ,Cardiovascular ,Obesity ,Cancer ,Evaluation of treatments and therapeutic interventions ,6.7 Physical ,Stroke ,Good Health and Well Being ,exercise ,circuit training ,randomized controlled trial ,obesity ,chronic inflammation ,adipose tissue ,breast cancer ,Clinical sciences ,Oncology and carcinogenesis - Abstract
BackgroundObesity is a significant contributor to breast cancer recurrence and mortality. A central mechanism by which obesity stimulates cancer progression is through chronic, low-grade inflammation in adipose tissue. Exercise interventions to target chronic inflammation has a potential to improve obesity- and breast cancer-related outcomes; however, no studies have investigated the roles of exercise in modulating adipose tissue inflammation in breast cancer survivors. Also, it is unclear which exercise prescription would be optimal to maximize the outcomes. Therefore, we designed a randomized controlled trial (Taking AIM at Breast Cancer: Targeting Adiposity and Inflammation with Movement to Improve Prognosis in Breast Cancer Survivors [AIM] Trial) to examine the mechanisms by which different modalities of exercise impact chronic inflammation as a biomarker of breast cancer prognosis.MethodsThe AIM trial is a prospective, three-armed, phase II randomized controlled trial investigating the effects of a 16-week supervised circuit aerobic and resistance exercise (CARE) program versus a traditional aerobic and resistance exercise (TARE) program and attention control (AC) on adipose tissue inflammation in breast cancer survivors. 276 patients who are diagnosed with stage 0-III breast cancer, post-treatment, sedentary, and centrally obese are randomized to one of the three groups. The CARE and TARE groups participate in thrice-weekly supervised exercise sessions for 16 weeks. The AC group are offered the CARE program after the intervention period. The primary endpoint is adipose tissue inflammation assessed by core biopsy and blood draw. The secondary and tertiary endpoints are sarcopenic obesity, physical fitness and function, and patient reported outcomes. The exploratory outcomes are long-term breast cancer outcomes.DiscussionThis is the first randomized controlled trial examining the effects of exercise on adipose tissue inflammation in obese, breast cancer survivors. Our findings are anticipated to contribute to a better understanding of exercise modalities and mechanisms on adipose tissue inflammation that can potentially improve breast cancer prognosis.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03091842 identifier [NCT#03091842].
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- 2022
118. Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response
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Lin, Chun-Yang, Wolf, Joshua, Brice, David C, Sun, Yilun, Locke, Macauley, Cherry, Sean, Castellaw, Ashley H, Wehenkel, Marie, Crawford, Jeremy Chase, Zarnitsyna, Veronika I, Duque, Daniel, Allison, Kim J, Allen, E Kaitlynn, Brown, Scott A, Mandarano, Alexandra H, Estepp, Jeremie H, Team, The SJTRC Study, Gaur, Aditya H, Hoffman, James M, Mori, Tomi, Tuomanen, Elaine I, Webby, Richard J, Hakim, Hana, Hayden, Randall T, Hijano, Diego R, Awad, Walid, Bajracharya, Resha, Clark, Brandi L, Cortez, Valerie, Dallas, Ronald H, Fabrizio, Thomas, Freiden, Pamela, Gowen, Ashleigh, Hodges, Jason, Kirk, Allison M, Roubidoux, Ericka Kirkpatrick, Mettelman, Robert C, Russell-Bell, Jamie, Souquette, Aisha, Sparks, James, Van de Velde, Lee-Ann, Vazquez-Pagan, Ana, Whitt, Kendall, Wilson, Taylor L, Wittman, David E, Wohlgemuth, Nicholas, Wu, Gang, Taylor, Charles, Molina-Paris, Carmen, Schultz-Cherry, Stacey, Tang, Li, Thomas, Paul G, and McGargill, Maureen A
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Medical Microbiology ,Biomedical and Clinical Sciences ,Pneumonia & Influenza ,Biodefense ,Biotechnology ,Lung ,Immunization ,Pneumonia ,Prevention ,Vaccine Related ,Emerging Infectious Diseases ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Good Health and Well Being ,Animals ,Antibodies ,Viral ,Antibody Formation ,Asymptomatic Infections ,COVID-19 ,Case-Control Studies ,Cell Line ,Common Cold ,Cross Reactions ,Female ,HEK293 Cells ,Humans ,Immunity ,Humoral ,Mice ,Mice ,Inbred C57BL ,SARS-CoV-2 ,Spike Glycoprotein ,Coronavirus ,SJTRC Study Team ,229E ,HKU1 ,NL63 ,OC43 ,antibody ,pre-existing immunity ,Microbiology ,Immunology ,Biochemistry and cell biology ,Medical microbiology - Abstract
SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to respiratory distress and death. A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoVs) impacts susceptibility to SARS-CoV-2 infection or immunity following infection and vaccination. Therefore, we analyzed samples from the same individuals before and after SARS-CoV-2 infection or vaccination. We found hCCCoV antibody levels increase after SARS-CoV-2 exposure, demonstrating cross-reactivity. However, a case-control study indicates that baseline hCCCoV antibody levels are not associated with protection against SARS-CoV-2 infection. Rather, higher magnitudes of pre-existing betacoronavirus antibodies correlate with more SARS-CoV-2 antibodies following infection, an indicator of greater disease severity. Additionally, immunization with hCCCoV spike proteins before SARS-CoV-2 immunization impedes the generation of SARS-CoV-2-neutralizing antibodies in mice. Together, these data suggest that pre-existing hCCCoV antibodies hinder SARS-CoV-2 antibody-based immunity following infection and provide insight on how pre-existing coronavirus immunity impacts SARS-CoV-2 infection, which is critical considering emerging variants.
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- 2022
119. Meta-evaluation of Conversational Search Evaluation Metrics
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Liu, Zeyang, Zhou, Ke, and Wilson, Max L.
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Computer Science - Information Retrieval ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Conversational search systems, such as Google Assistant and Microsoft Cortana, enable users to interact with search systems in multiple rounds through natural language dialogues. Evaluating such systems is very challenging given that any natural language responses could be generated, and users commonly interact for multiple semantically coherent rounds to accomplish a search task. Although prior studies proposed many evaluation metrics, the extent of how those measures effectively capture user preference remains to be investigated. In this paper, we systematically meta-evaluate a variety of conversational search metrics. We specifically study three perspectives on those metrics: (1) reliability: the ability to detect "actual" performance differences as opposed to those observed by chance; (2) fidelity: the ability to agree with ultimate user preference; and (3) intuitiveness: the ability to capture any property deemed important: adequacy, informativeness, and fluency in the context of conversational search. By conducting experiments on two test collections, we find that the performance of different metrics varies significantly across different scenarios whereas consistent with prior studies, existing metrics only achieve a weak correlation with ultimate user preference and satisfaction. METEOR is, comparatively speaking, the best existing single-turn metric considering all three perspectives. We also demonstrate that adapted session-based evaluation metrics can be used to measure multi-turn conversational search, achieving moderate concordance with user satisfaction. To our knowledge, our work establishes the most comprehensive meta-evaluation for conversational search to date., Comment: 43 pages
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- 2021
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120. Direct Multipoint Observations Capturing the Reformation of a Supercritical Fast Magnetosonic Shock
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Turner, D. L., Wilson III, L. B., Goodrich, K. A., Madanian, H., Schwartz, S. J., Liu, T. Z., Johlander, A., Caprioli, D., Cohen, I. J., Gershman, D., Hietala, H., Westlake, J. H., Lavraud, B., Contel, O. Le, and Burch, J. L.
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Physics - Space Physics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Using multipoint Magnetospheric Multiscale (MMS) observations in an unusual string-of-pearls configuration, we examine in detail observations of the reformation of a fast magnetosonic shock observed on the upstream edge of a foreshock transient structure upstream of Earth's bow shock. The four MMS spacecraft were separated by several hundred km, comparable to suprathermal ion gyro-radius scales or several ion inertial lengths. At least half of the shock reformation cycle was observed, with a new shock ramp rising up out of the "foot" region of the original shock ramp. Using the multipoint observations, we convert the observed time-series data into distance along the shock normal in the shock's rest frame. That conversion allows for a unique study of the relative spatial scales of the shock's various features, including the shock's growth rate, and how they evolve during the reformation cycle. Analysis indicates that: the growth rate increases during reformation, electron-scale physics play an important role in the shock reformation, and energy conversion processes also undergo the same cyclical periodicity as reformation. Strong, thin electron-kinetic-scale current sheets and large-amplitude electrostatic and electromagnetic waves are reported. Results highlight the critical cross-scale coupling between electron-kinetic- and ion-kinetic-scale processes and details of the nature of nonstationarity, shock-front reformation at collisionless, fast magnetosonic shocks., Comment: In press and to be published in Astrophysical Journal Letters in 2021
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- 2021
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121. An urban-to-rural continuum of malaria risk: new analytic approaches characterize patterns in Malawi
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Larson, Peter S, Eisenberg, Joseph NS, Berrocal, Veronica J, Mathanga, Don P, and Wilson, Mark L
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Biological Sciences ,Biomedical and Clinical Sciences ,Microbiology ,Clinical Sciences ,Medical Microbiology ,Rare Diseases ,Malaria ,Infectious Diseases ,Vector-Borne Diseases ,Aetiology ,2.2 Factors relating to the physical environment ,Infection ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Child ,Child ,Preschool ,Female ,Humans ,Infant ,Malawi ,Male ,Middle Aged ,Prevalence ,Risk Factors ,Rural Population ,Urban Population ,Young Adult ,Urbanicity ,Environmental risk ,Malaria prevention ,Remote sensing ,Spatial analysis ,Public Health and Health Services ,Tropical Medicine ,Medical microbiology ,Public health - Abstract
BackgroundThe urban-rural designation has been an important risk factor in infectious disease epidemiology. Many studies rely on a politically determined dichotomization of rural versus urban spaces, which fails to capture the complex mosaic of infrastructural, social and environmental factors driving risk. Such evaluation is especially important for Plasmodium transmission and malaria disease. To improve targeting of anti-malarial interventions, a continuous composite measure of urbanicity using spatially-referenced data was developed to evaluate household-level malaria risk from a house-to-house survey of children in Malawi.MethodsChildren from 7564 households from eight districts throughout Malawi were tested for presence of Plasmodium parasites through finger-prick blood sampling and slide microscopy. A survey questionnaire was administered and latitude and longitude coordinates were recorded for each household. Distances from households to features associated with high and low levels of development (health facilities, roads, rivers, lakes) and population density were used to produce a principal component analysis (PCA)-based composite measure for all centroid locations of a fine geo-spatial grid covering Malawi. Regression methods were used to test associations of the urbanicity measure against Plasmodium infection status and to predict parasitaemia risk for all locations in Malawi.ResultsInfection probability declined with increasing urbanicity. The new urbanicity metric was more predictive than either a governmentally defined rural/urban dichotomous variable or a population density variable. One reason for this was that 23% of cells within politically defined rural areas exhibited lower risk, more like those normally associated with "urban" locations.ConclusionsIn addition to increasing predictive power, the new continuous urbanicity metric provided a clearer mechanistic understanding than the dichotomous urban/rural designations. Such designations often ignore urban-like, low-risk pockets within traditionally rural areas, as were found in Malawi, along with rural-like, potentially high-risk environments within urban areas. This method of characterizing urbanicity can be applied to other infectious disease processes in rapidly urbanizing contexts.
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- 2021
122. School-Level Efforts to Address Sexual Health and Risky Sexual Behavior among Students in Texas Alternative High Schools
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Johnson, Karen E., Conn, Kathryn L., Osborne, Cynthia, Wilson, Kelly L., and Rew, Lynn
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We compared sexual/reproductive health services and sexuality education topics provided in Texas alternative high schools (AHSs) with the prevalence of sexual risk behaviors among students in AHS. Using cross-sectional data from convenience samples of 14 principals, 14 lead health educators, and 515 students, we calculated descriptive statistics for 20 services and 15 sexuality education topics provided by AHSs and seven sexual risk behaviors among students in AHS. AHSs provided few sexual/reproductive health services and limited educational content, despite high levels of sexual risk taking among students. For example, no AHSs taught students about proper condom use, yet 84% of students have had sex. Findings provide preliminary evidence of unmet needs for school-based sexual/reproductive health services and comprehensive sexuality education in AHS settings. Future investigation with larger, representative samples is needed to assess the provision of sexual/reproductive health services and sexuality education in AHSs and monitor sexual risk behaviors in the AHS population.
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- 2022
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123. Cross-reactive antibody response to mRNA SARS-CoV-2 vaccine after recent COVID-19-specific monoclonal antibody therapy
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Schultz-Cherry, Stacey, McGargill, Maureen A, Thomas, Paul G, Estepp, Jeremie H, Gaur, Aditya H, Allen, E Kaitlynn, Allison, Kim J, Tang, Li, Webby, Richard J, Cherry, Sean D, Lin, Chun-Yang, Fabrizio, Thomas, Tuomanen, Elaine I, Wolf, Joshua, Roubidoux, Ericka Kirkpatrick, Freiden, Pamela, Mori, Tomi, Hijano, Diego R, Hakim, Hana, Brice, David C, Castellaw, Ashley, Krammer, Florian, Wittman, David E, Hodges, Jason, Dallas, Ronald H, Cortez, Valerie, Vazquez-Pagan, Ana, Bajracharya, Resha, Clark, Brandi L, Van de Velde, Lee-Ann, Awad, Walid, Wilson, Taylor L, Kirk, Allison M, Hayden, Randall T, Hoffman, James, Russell-Bell, Jamie, and Sparks, James
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Biomedical and Clinical Sciences ,Immunology ,Immunization ,Biotechnology ,Cancer ,Lung ,Infectious Diseases ,Biodefense ,Clinical Research ,Pneumonia & Influenza ,Prevention ,Pneumonia ,Emerging Infectious Diseases ,Vaccine Related ,Prevention of disease and conditions ,and promotion of well-being ,3.4 Vaccines ,Infection ,Good Health and Well Being ,SJTRC Investigative Team ,COVID-19 ,SARS-CoV-2 ,antibody ,bamlanivimab ,vaccine failure ,Clinical sciences ,Medical microbiology - Abstract
The efficacy of coronavirus disease 2019 (COVID-19) vaccines administered after COVID-19-specific monoclonal antibody is unknown, and "antibody interference" might hinder immune responses leading to vaccine failure. In an institutional review board-approved prospective study, we found that an individual who received mRNA COVID-19 vaccination
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- 2021
124. Electrically switchable anisotropic polariton propagation in a ferroelectric van der Waals semiconductor
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Luo, Yue, Mao, Nannan, Ding, Dapeng, Chiu, Ming-Hui, Ji, Xiang, Watanabe, Kenji, Taniguchi, Takashi, Tung, Vincent, Park, Hongkun, Kim, Philip, Kong, Jing, and Wilson, William L.
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- 2023
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125. The clinical relevance of human papillomavirus negative status in unsatisfactory cervical cytology
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Barakzai, Syem K., Nguyen, Ailene, Sehgal, Sanchala, Matsuo, Koji, Shi, Wenjing, Veran-Taguibao, Sonia, Wilson, Melissa L., and Gordon, Brian J.
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- 2023
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126. The Dynamics of a High Mach Number Quasi-Perpendicular Shock: MMS Observations
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Madanian, H., Desai, M. I., Schwartz, S. J., Wilson III, L. B., Fuselier, S. A., Burch, J. L., Contel, O. Le, Turner, D. L., Ogasawara, K., Brosius, A. L., Russell, C. T., Ergun, R. E., Ahmadi, N., Gershman, D. J., and Lindqvist, P. -A.
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Physics - Plasma Physics ,Physics - Space Physics - Abstract
Shock parameters at Earth's bow shock in rare instances can approach the Mach numbers predicted at supernova remnants. We present our analysis of a high Alfv\'en Mach number ($M_A= 27$) shock utilizing multipoint measurements from the Magnetospheric Multiscale (MMS) spacecraft during a crossing of Earth's quasi-perpendicular bow shock. We find that the shock dynamics are mostly driven by reflected ions, perturbations that they generate, and nonlinear amplification of the perturbations. Our analyses show that reflected ions create modest magnetic enhancements upstream of the shock which evolve in a nonlinear manner as they traverse the shock foot. They can transform into proto-shocks that propagate at small angles to the magnetic field and towards the bow shock. The nonstationary bow shock shows signatures of both reformation and surface ripples. Our observations indicate that although shock reformation occurs, the main shock layer never disappears. These observations are at high plasma $\beta$, a parameter regime which has not been well explored by numerical models., Comment: Accepted by the Astrophysical Journal
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- 2020
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127. The Herschel Orion Protostar Survey: Far-Infrared Photometry and Colors of Protostars and Their Variations across Orion A and B
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Fischer, William J., Megeath, S. Thomas, Furlan, E., Stutz, Amelia M., Stanke, Thomas, Tobin, John J., Osorio, Mayra, Manoj, P., Di Francesco, James, Allen, Lori E., Watson, Dan M., Wilson, T. L., and Henning, Thomas
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The degree to which the properties of protostars are affected by environment remains an open question. To investigate this, we look at the Orion A and B molecular clouds, home to most of the protostars within 500 pc. At ~400 pc, Orion is close enough to distinguish individual protostars across a range of environments in terms of both the stellar and gas projected densities. As part of the Herschel Orion Protostar Survey (HOPS), we used the Photodetector Array Camera and Spectrometer (PACS) to map 108 partially overlapping square fields with edge lengths of 5 arcmin or 8 arcmin and measure the 70 micron and 160 micron flux densities of 338 protostars within them. In this paper we examine how these flux densities and their ratio depend on evolutionary state and environment within the Orion complex. We show that Class 0 protostars occupy a region of the 70 micron flux density versus 160 micron to 70 micron flux density ratio diagram that is distinct from their more evolved counterparts. We then present evidence that the Integral-Shaped Filament (ISF) and Orion B contain protostars with more massive envelopes than those in the more sparsely populated LDN 1641 region. This can be interpreted as evidence for increasing star formation rates in the ISF and Orion B or as a tendency for more massive envelopes to be inherited from denser birth environments. We also provide technical details about the map-making and photometric procedures used in the HOPS program., Comment: Accepted by ApJ
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- 2020
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128. The HD 217107 Planetary System: Twenty Years of Radial Velocity Measurements
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Giovinazzi, Mark R., Blake, Cullen H., Eastman, Jason D., Wright, Jason, McCrady, Nate, Wittenmyer, Rob, Johnson, John A., Plavchan, Peter, Sliski, David H., Wilson, Maurice L., Johnson, Samson A., Horner, Jonathan, Kane, Stephen R., Houghton, Audrey, García-Mejía, Juliana, and Glaser, Joseph P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The hot Jupiter HD 217107 b was one of the first exoplanets detected using the radial velocity (RV) method, originally reported in the literature in 1999. Today, precise RV measurements of this system span more than 20 years, and there is clear evidence for a longer-period companion, HD 217107 c. Interestingly, both the short-period planet ($P_\mathrm{b}\sim7.13$ d) and long-period planet ($P_\mathrm{c}\sim5059$ d) have significantly eccentric orbits ($e_\mathrm{b}\sim0.13$ and $e_\mathrm{c}\sim0.40$). We present 42 additional RV measurements of this system obtained with the MINERVA telescope array and carry out a joint analysis with previously published RV measurements from four different facilities. We confirm and refine the previously reported orbit of the long-period companion. HD 217107 b is one of a relatively small number of hot Jupiters with an eccentric orbit, opening up the possibility of detecting precession of the planetary orbit due to General Relativistic effects and perturbations from other planets in the system. In this case, the argument of periastron, $\omega$, is predicted to change at the level of $\sim$0.8$^\circ$ century$^{-1}$. Despite the long time baseline of our observations and the high quality of the RV measurements, we are only able to constrain the precession to be $\dot{\omega}<65.9^\circ$ century$^{-1}$. We discuss the limitations of detecting the subtle effects of precession in exoplanet orbits using RV data., Comment: 8 pages, 3 figures, accepted for publication in Astronomische Nachrichten
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- 2020
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129. Probing the Z = 6 spin-orbit shell gap with (p,2p) quasi-free scattering reactions
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Syndikus, I., Petri, M., Macchiavelli, A. O., Paschalis, S., Bertulani, C. A., Aumann, T., Alvarez-Pol, H., Atar, L., Beceiro-Novo, S., Benlliure, J., Boillos, J. M., Boretzky, K., Borge, M. J. G., Brown, B. A., Caamaño, M., Caesar, C., Casarejos, E., Catford, W., Cederkall, J., Chulkov, L. V., Cortina-Gil, D., Cravo, E., Crespo, R., Dillmann, I., Fernández, P. Díaz, Elekes, Z., Enders, J., Farinon, F., Fraile, L. M., Redondo, D. Galaviz, Geissel, H., Gernhäuser, R., Golubev, P., Göbel, K., Heil, M., Heine, M., Heinz, A., Henriques, A., Holl, M., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Kröll, T., Kurz, N., Langer, C., Bleis, T. Le, Machado, J. F. D. C., Marganiec-Gałazka, J., Nacher, E., Nilsson, T., Nociforo, C., Panin, V., Perea, A., Pietri, S. B., Plag, R., Reifarth, R., Revel, A., Ribeiro, G., Rigollet, C., Rossi, D. M., Savran, D., Scheit, H., Simon, H., Sorlin, O., Tengblad, O., Togano, Y., Vandebrouck, M., Volkov, V., Wheldon, F. Wamers C., Wilson, G. L., Winfield, J. S., Weick, H., Woods, P., Yakorev, D., Zhukov, M., Zilges, A., and Zuber, K.
- Subjects
Nuclear Experiment - Abstract
The evolution of the traditional nuclear magic numbers away from the valley of stability is an active field of research. Experimental efforts focus on providing key spectroscopic information that will shed light into the structure of exotic nuclei and understanding the driving mechanism behind the shell evolution. In this work, we investigate the Z = 6 spin-orbit shell gap towards the neutron dripline. To do so, we employed $^{A}$N(p,2p)$^{A-1}$C quasi-free scattering reactions to measure the proton component of the 2$^+_1$ state of $^{16,18,20}$C. The experimental findings support the notion of a moderate reduction of the proton 1p$_{1/2}$-1p$_{3/2}$ spin-orbit splitting, at variance to recent claims for a prevalent Z = 6 magic number towards the neutron dripline., Comment: 27 pages, 5 figures, 2 tables. Submitted to Physics Letter B
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- 2020
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130. Quantum Immortality and Non-Classical Logic
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Wilson, Phillip L.
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Physics - History and Philosophy of Physics ,Mathematics - History and Overview ,Quantum Physics - Abstract
The Everett Box is a device in which an observer and a lethal quantum apparatus are isolated from the rest of the universe. On a regular basis, successive trials occur, in each of which an automatic measurement of a quantum superposition inside the apparatus either causes instant death or does nothing to the observer. From the observer's perspective, the chances of surviving $m$ trials monotonically decreases with increasing $m$. As a result, if the observer is still alive for sufficiently large $m$ she must reject any interpretation of quantum mechanics which is not the many-worlds interpretation (MWI), since surviving $m$ trials becomes vanishingly unlikely in a single world, whereas a version of the observer will necessarily survive in the branching MWI universe. Here we ask whether this conclusion still holds if rather than a classical understanding of limits built on classical logic we instead require our physics to satisfy a computability requirement by investigating the Everett Box in a model of a computational universe running on a variety of constructive logic, Recursive Constructive Mathematics. We show that although the standard Everett argument rejecting non-MWI interpretations is no longer valid, we can show that Everett's conclusion still holds within a computable universe. Thus we argue that Everett's argument is strengthened and any counter-argument must be strengthened, since it holds not only in classical logic (with embedded notions of continuity and infinity) but also in a computable logic., Comment: 14 pages
- Published
- 2020
131. Capacity Value of Solar Power and Other Variable Generation
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Awara, S., Lynch, M., Pfenninger, S., Schell, K., Sioshansi, R., Staffell, I., Samaan, N., Tindemans, S. H., Wilson, A. L., Zachary, S., Zareipour, H., and Dent, C. J.
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Statistics - Applications - Abstract
This paper reviews methods that are used for adequacy risk assessment considering solar power and for assessment of the capacity value of solar power. The properties of solar power are described as seen from the perspective of the power-system operator, comparing differences in energy availability and capacity factors with those of wind power. Methodologies for risk calculations considering variable generation are surveyed, including the probability background, statistical-estimation approaches, and capacity-value metrics. Issues in incorporating variable generation in capacity markets are described, followed by a review of applied studies considering solar power. Finally, recommendations for further research are presented., Comment: 8 pages, 3 figures, submitted to IEEE TPS
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- 2020
132. Multiple Tunable Hyperbolic Resonances in Broadband Infrared Carbon-Nanotube Metamaterials
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Roberts, John Andris, Ho, Po-Hsun, Yu, Shang-Jie, Wu, Xiangjin, Luo, Yue, Wilson, William L., Falk, Abram L., and Fan, Jonathan A.
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Physics - Optics ,Physics - Applied Physics - Abstract
Aligned, densely-packed carbon nanotube metamaterials prepared using vacuum filtration are an emerging infrared nanophotonic material. We report multiple hyperbolic plasmon resonances, together spanning the mid-infrared, in individual resonators made from aligned and densely-packed carbon nanotubes. In the first near-field scanning optical microscopy (NSOM) imaging study of nanotube metamaterial resonators, we observe distinct deeply-subwavelength field profiles at the fundamental and higher-order resonant frequencies. The wafer-scale area of the nanotube metamaterials allows us to combine this near-field imaging with a systematic far-field spectroscopic study of the scaling properties of many resonator arrays. Thorough theoretical modeling agrees with these measurements and identifies the resonances as higher-order Fabry-P\'erot (FP) resonances of hyperbolic waveguide modes. Nanotube resonator arrays show broadband extinction from 1.5-10 {\mu}m and reversibly switchable extinction in the 3-5 {\mu}m atmospheric transparency window through the coexistence of multiple modes in individual ribbons. Broadband carbon nanotube metamaterials supporting multiple resonant modes are a promising candidate for ultracompact absorbers, tunable thermal emitters, and broadband sensors in the mid-infrared.
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- 2020
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133. Bedrock reconstruction from free surface data for unidirectional glacier flow with basal slip
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McGeorge, Elizabeth K., Sellier, Mathieu, Moyers-Gonzalez, Miguel, and Wilson, Phillip L.
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Physics - Geophysics ,Physics - Fluid Dynamics - Abstract
Glacier ice flow is shaped and defined by several properties, including the bedrock elevation profile and the basal slip distribution. The effect of these two basal properties can present in similar ways in the surface. For bedrock recovery this makes distinguishing between them an interesting and complex problem. The results of this paper show that in some synthetic test cases it is indeed possible to distinguish and recover both bedrock elevation and basal slip given free surface elevation and free surface velocity. The unidirectional shallow ice approximation is used to compute steady state surface data for a number of synthetic cases with different bedrock profiles and basal slip distributions. A simple inversion method based on Newton's method is applied to the known surface data to return the bedrock profile and basal slip distribution. In each synthetic test case, the inversion was successful in recovering both the bedrock elevation profile and the basal slip distribution variables. These results imply that there is a unique bedrock profile and basal slip which give rise to a unique combination of free surface velocity and free surface elevation., Comment: 25 pages, 14 figures
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- 2020
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134. ARTEMIS Observations of Plasma Waves in Laminar and Perturbed Interplanetary Shocks
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Davis, L., Cattell, C. A., Wilson III, L. B., Cohen, Z. A., Breneman, A. W., and Hanson, E. L. M.
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Physics - Space Physics - Abstract
The 'Acceleration, Reconnection, Turbulence and Electrodynamics of the Moon's Interaction with the Sun' (ARTEMIS) mission provides a unique opportunity to study the structure of interplanetary shocks and the associated generation of plasma waves with frequencies between ~50-8000 Hz due to its long duration electric and magnetic field burst waveform captures. We compare wave properties and occurrence rates at 11 quasi-perpendicular interplanetary shocks with burst data within 10 minutes (~3200 proton gyroradii upstream, ~1900 downstream) of the shock ramp. A perturbed shock is defined as possessing a large amplitude whistler precursor in the quasi-static magnetic field with an amplitude greater than 1/3 the difference between the upstream and downstream average magnetic field magnitudes; laminar shocks lack these large precursors and have a smooth, step function-like transition. In addition to wave modes previously observed, including ion acoustic, whistler, and electrostatic solitary waves, waves in the ion acoustic frequency range that show rapid temporal frequency change are common. The ramp region of the two laminar shocks with burst data in the ramp contained a wide range of large amplitude wave modes whereas the one perturbed shock with ramp burst data contained no such waves. Energy dissipation through wave-particle interactions is more prominent in these laminar shocks than the perturbed shock. The wave occurrence rates for laminar shocks are higher in the transition region, especially the ramp, than downstream. Perturbed shocks have approximately 2-3 times the wave occurrence rate downstream than laminar shocks.
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- 2020
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135. Determining Cosmological Constant Using Gravitational Wave Information
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Wilson, Thomas L.
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Physics - General Physics - Abstract
It is shown in Einstein gravity that the cosmological constant Lambda introduces a graviton mass m into the theory, a result that will be derived from the Regge-Wheeler-Zerilli problem for a particle falling onto a Kottler-Schwarzschild mass with Lambda. The value of m is precisely the Spin-2 gauge line appearing on the Lambda versus m2 phase diagram for Spin-2, the partially massless gauge lines introduced by Deser & Waldron and described as the Higuchi bound. Note that this graviton is unitary with only four polarization degrees of freedom (helicities plus & minus 2 and 1, but not 0 because a scalar gauge symmetry removes it). The conclusion is drawn that Einstein gravity (with Lambda) is a partially massless gravitation theory which has lost its helicity 0 due to a scalar gauge symmetry. That poses a challenge for gravitational wave antennas as to whether they can measure the loss of this gauge symmetry. Also, given the recent results measuring the Hubble constant Ho from LIGO-Virgo data, it is then shown that Lambda can be determined from the LIGO results for the graviton mass m and Ho. This is yet another multi-messenger source for determining the three parameters Lambda, m, and Ho in astrophysics and cosmology, at a time when there is much disparity in measurements of Ho., Comment: 4 pages, No figures
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- 2020
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136. Electron energy partition across interplanetary shocks: III. Analysis
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Wilson III, L. B., Chen, Li-Jen, Wang, Shan, Schwartz, Steven J., Turner, Drew L., Stevens, Michael L., Kasper, Justin C., Osmane, Adnane, Caprioli, Damiano, Bale, Stuart D., Pulupa, Marc P., Salem, Chadi S., and Goodrich, Katherine A.
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Physics - Space Physics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics - Abstract
Analysis of model fit results of 15,210 electron velocity distribution functions (VDFs), observed within $\pm$2 hours of 52 interplanetary (IP) shocks by the Wind spacecraft near 1 AU, is presented as the third and final part on electron VDFs near IP shocks. The core electrons and protons dominate in the magnitude and change in the partial-to-total thermal pressure ratio, with the core electrons often gaining as much or more than the protons. Only a moderate positive correlation is observed between the electron temperature and the kinetic energy change across the shock, while weaker, if any, correlations were found with any other macroscopic shock parameter. No VDF parameter correlated with the shock normal angle. The electron VDF evolves from a narrowly peaked core with flaring suprathermal tails in the upstream to either a slightly hotter core with steeper tails or much hotter flattop core with even steeper tails downstream of the weaker and strongest shocks, respectively. Both quasi-static and fluctuating fields are examined as possible mechanisms modifying the VDF but neither is sufficient alone. For instance, flattop VDFs can be generated by nonlinear ion acoustic wave stochastic acceleration (i.e., inelastic collisions) while other work suggested they result from the combination of quasi-static and fluctuating fields. This three-part study shows that not only are these systems not thermodynamic in nature, even kinetic models may require modification to include things like inelastic collision operators to properly model electron VDF evolution across shocks or in the solar wind., Comment: 30 pages, 10 figures, 3 tables, to be submitted to Astrophys. J
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- 2020
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137. Bayesian estimates of transmission line outage rates that consider line dependencies
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Zhou, Kai, Cruise, James R., Dent, Chris J., Dobson, Ian, Wehenkel, Louis, Wang, Zhaoyu, and Wilson, Amy L.
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Statistics - Applications ,Electrical Engineering and Systems Science - Systems and Control ,Physics - Physics and Society - Abstract
Transmission line outage rates are fundamental to power system reliability analysis. Line outages are infrequent, occurring only about once a year, so outage data are limited. We propose a Bayesian hierarchical model that leverages line dependencies to better estimate outage rates of individual transmission lines from limited outage data. The Bayesian estimates have a lower standard deviation than estimating the outage rates simply by dividing the number of outages by the number of years of data, especially when the number of outages is small. The Bayesian model produces more accurate individual line outage rates, as well as estimates of the uncertainty of these rates. Better estimates of line outage rates can improve system risk assessment, outage prediction, and maintenance scheduling.
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- 2020
138. Three questions to address rigour and reproducibility concerns in your grant proposal
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Wilson, Jennifer L and Botham, Crystal M
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Creative and Professional Writing ,Creative Arts and Writing ,Careers ,Funding ,Peer review ,General Science & Technology - Published
- 2021
139. PhenClust, a standalone tool for identifying trends within sets of biological phenotypes using semantic similarity and the Unified Medical Language System metathesaurus
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Wilson, Jennifer L, Wong, Mike, Stepanov, Nicholas, Petkovic, Dragutin, and Altman, Russ
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Health Services and Systems ,Health Sciences ,Networking and Information Technology R&D (NITRD) ,Good Health and Well Being ,systems biology ,phenotype analysis ,high-throughput analysis ,network analysis ,computational tools ,Docker containers ,Health services and systems - Abstract
ObjectivesWe sought to cluster biological phenotypes using semantic similarity and create an easy-to-install, stable, and reproducible tool.Materials and methodsWe generated Phenotype Clustering (PhenClust)-a novel application of semantic similarity for interpreting biological phenotype associations-using the Unified Medical Language System (UMLS) metathesaurus, demonstrated the tool's application, and developed Docker containers with stable installations of two UMLS versions.ResultsPhenClust identified disease clusters for drug network-associated phenotypes and a meta-analysis of drug target candidates. The Dockerized containers eliminated the requirement that the user install the UMLS metathesaurus.DiscussionClustering phenotypes summarized all phenotypes associated with a drug network and two drug candidates. Docker containers can support dissemination and reproducibility of tools that are otherwise limited due to insufficient software support.ConclusionPhenClust can improve interpretation of high-throughput biological analyses where many phenotypes are associated with a query and the Dockerized PhenClust achieved our objective of decreasing installation complexity.
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- 2021
140. Quantum Secrecy in Thermal States II
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Newton, Elizabeth, Ghesquière, Anne, Wilson, Freya L., Varcoe, Benjamin T. H., and Moseley, Martin
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Quantum Physics - Abstract
In this paper we consider a scheme for cryptographic key distribution based on a variation of continuous variable quantum key distribution called central broadcast. In the continuous variable central broadcast scheme, security arises from discord present in the Hanbury Brown and Twiss effect from a thermal source. The benefit of this scheme is that it expands the range of frequencies into the microwave regime. Longer wavelengths, where the thermal photon number is higher and correlations remain robust over long distances, may even be preferable to optical wavelengths. Assming that Alice controls the source but not the distribution of the light (eg satellite broadcasts), then we demonstrate that the central broadcast scheme is robust to an entangling cloner attack. We establish the security of the protocol both experimentally and theoretically.
- Published
- 2019
141. Cannabis and the Gut–Brain Axis Communication in HIV Infection
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Wilson, Natalie L, Peterson, Scott N, and Ellis, Ronald J
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Medical Microbiology ,Biomedical and Clinical Sciences ,Psychology ,Substance Misuse ,Drug Abuse (NIDA only) ,HIV/AIDS ,Cannabinoid Research ,Neurosciences ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Good Health and Well Being ,Brain-Gut Axis ,Cannabis ,HIV Infections ,Humans ,Neuroinflammatory Diseases ,endocannabinoids ,cannabis ,gut– ,brain axis ,HIV ,microbiome ,gut–brain axis ,Clinical sciences ,Pharmacology and pharmaceutical sciences ,Biological psychology - Abstract
People living with HIV infection (PWH) disclose that cannabis is an effective strategy for alleviating symptoms associated with HIV disease. However, some medical providers feel ill-informed to engage in evidence-based conversations. HIV leads to alterations in the gut microbiome, gut-brain axis signaling, and chronic inflammation. The endocannabinoid system regulates homeostasis of multiple organ systems. When deficient, dysregulation of the gut-brain axis can result in chronic inflammation and neuroinflammation. Cannabis along with the naturally occurring endocannabinoids has antioxidant and anti-inflammatory properties that can support healing and restoration as an adjunctive therapy. The purpose of this literature review is to report the physiologic mechanisms that occur in the pathology of HIV and discuss potential benefits of cannabinoids in supporting health and reducing the negative effects of comorbidities in PWH.
- Published
- 2021
142. A Prospective Multicenter Registry on Feasibility, Safety, and Outcome of Endovascular Recanalization in Childhood Stroke (Save ChildS Pro)
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Sporns, Peter B, Kemmling, André, Lee, Sarah, Fullerton, Heather, Kunz, Wolfgang G, Wilson, Jenny L, Mackay, Mark T, Steinlin, Maja, Fiehler, Jens, Psychogios, Marios, and Wildgruber, Moritz
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Neurosciences ,Clinical Research ,Pediatric ,Clinical Trials and Supportive Activities ,Stroke ,Brain Disorders ,stroke ,ischemic stroke ,arterial ischemic stroke ,thrombectomy ,mechanical thrombectomy ,intravenous thrombolysis ,childhood stroke ,pediatric stroke ,Psychology ,Clinical sciences ,Biological psychology - Abstract
Rationale: Early evidence for the benefit of mechanical thrombectomy (MT) in pediatric patients with intracranial large vessel occlusion has been shown in previous retrospective cohorts. Higher-level evidence is needed to overcome the limitations of these studies such as the lack of a control group and the retrospective design. Randomized trials will very likely not be feasible, and several open questions remain, for example, the impact of arteriopathic etiologies or a possible lower age limit for MT. Save ChildS Pro therefore aims to demonstrate the safety and effectiveness of MT in pediatric patients compared to the best medical management and intravenous thrombolysis. Design: Save ChildS Pro is designed as a worldwide multicenter prospective registry comparing the safety and effectiveness of MT to the best medical care alone in the treatment of pediatric arterial ischemic stroke (AIS). It will include pediatric patients (
- Published
- 2021
143. Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12
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Sandhu, Sumit, Sou, Ieng F, Hunter, Jill E, Salmon, Lucy, Wilson, Caroline L, Perkins, Neil D, Hunter, Neil, Davies, Owen R, and McClurg, Urszula L
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Biological Sciences ,Genetics ,Cancer ,Animals ,Cell Cycle Proteins ,Cell Line ,Tumor ,Centrosome ,Gene Expression ,Humans ,Mice ,Synaptonemal Complex ,Biological sciences ,Biomedical and clinical sciences - Abstract
The synaptonemal complex (SC) is a supramolecular protein scaffold that mediates chromosome synapsis and facilitates crossing over during meiosis. In mammals, SC proteins are generally assumed to have no other function. Here, we show that SC protein TEX12 also localises to centrosomes during meiosis independently of chromosome synapsis. In somatic cells, ectopically expressed TEX12 similarly localises to centrosomes, where it is associated with centrosome amplification, a pathology correlated with cancer development. Indeed, TEX12 is identified as a cancer-testis antigen and proliferation of some cancer cells is TEX12-dependent. Moreover, somatic expression of TEX12 is aberrantly activated via retinoic acid signalling, which is commonly disregulated in cancer. Structure-function analysis reveals that phosphorylation of TEX12 on tyrosine 48 is important for centrosome amplification but not for recruitment of TEX12 to centrosomes. We conclude that TEX12 normally localises to meiotic centrosomes, but its misexpression in somatic cells can contribute to pathological amplification and dysfunction of centrosomes in cancers.
- Published
- 2021
144. Correction: Addressing Evaluation Barriers with Early Innovation Development for Adolescent-Focused Sexual and Reproductive Health Interventions
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Wilson, Kelly L., Axelson, Sarah, Garney, Whitney R., Garcia, Kristen M., Suellentrop, Katy, and Esquivel, Christi H.
- Published
- 2024
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145. Development of the Abbreviated Technology Anxiety Scale (ATAS)
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Wilson, Matthew L., Huggins-Manley, Anne Corinne, Ritzhaupt, Albert D., and Ruggles, Krista
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- 2023
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146. Social Support, Discrimination, and Self-Esteem in LGBTQ+ High School and Post-Secondary Students
- Author
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Taylor, Kirstie, Coulombe, Simon, Coleman, Todd A., Cameron, Ruth, Davis, Charlie, Wilson, Ciann L., Woodford, Michael R., and Travers, Robb
- Abstract
LGBTQ+ (lesbian, gay, bisexual, transgender, queer, plus) people, compared to their heterosexual and/or cisgender (non-transgender) counterparts, are more likely to be discriminated against based on their gender or sexual identities. Drawing on data from The OutLook Study in Waterloo Region, Ontario, Canada this paper examines discrimination and social support among high school and post-secondary students, and how they are related to self-esteem. We found that transgender students in high school reported significantly higher levels of direct transphobia and of victimization compared to transgender post-secondary students. We found indirect homophobia and indirect transphobia had a significant adverse relationship to self-esteem. Further, social support from friends was related to higher self-esteem for cisgender LGBQ students, but not for transgender students. These findings have the potential to inform school-based policies and mental health interventions in support of improved wellbeing for LGBTQ+ students.
- Published
- 2022
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147. Assessing Digital Nativeness in Pre-Service Teachers: Analysis of the Digital Natives Assessment Scale and Implications for Practice
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Wilson, Matthew L., Hall, Jacob A., and Mulder, David J.
- Abstract
"Digital native," the term ubiquitously used to describe contemporary learners, is fraught with debate over its meaning and measurement. The Digital Natives Assessment Scale (DNAS) was developed and validated to measure digital nativeness. This study extends the DNAS validation discussion with data from 178 participants in three teacher preparation programs in the United States. Confirmatory factor analysis results indicate the data fully fit neither Teo's validated 21-item, 4-factor model, nor a theorized 30-item, 4-factor model. Further analyses showed the DNAS may not address the factors of digital nativeness. Discussion contributes dialog to the ongoing and growing critique of the construct. Future research within educational technology and beyond should focus on alternative conceptualizations of contemporary learners and educators.
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- 2022
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148. A Case Study Evaluating Youth Acceptability of 'Using the Connect' -- A Sexuality Education Game-Based Learning Program
- Author
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Esquivel, Christi H., Wilson, Kelly L., Garney, Whitney R., McNeill, Elisa Beth, McMaughan, Darcy Jones, Brown, Sydney, and Graves-Boswell, Taylor
- Abstract
Game-based learning offers an interactive and effective way to teach health content and skills. This article discusses feasibility testing of "Using the Connect" ("UTC"), an innovative, game-based sexuality education program to evaluate its acceptability among youth. Utilizing mixed methods in a single case study design, qualitative and quantitative data was collected from youth (surveys, facilitated discussions, and observations). Qualitative data triangulated quantitative findings that youth liked the program design, felt the games and content were relatable, and learned knowledge and skills around adolescent development, accessing information, communication, and making healthy decisions through playing the games. Overall, "UTC" was highly acceptable to the youth; they had fun and learned information and skills. Not only would most participants recommend the program to friends, all reported they would participate in the program again and use the information they learned in the future.
- Published
- 2022
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149. Crafting Connections in Post-COVID Classrooms: Learning University Mathematics through Craft
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McLeod, Jeanette C., Wilson, Phillip L., Pomeroy, David, and Alderton, Julie
- Abstract
In 2020, after New Zealand emerged from its short-lived lockdown and students returned to university campuses, mathematicians Jeanette McLeod and Phil Wilson from the University of Canterbury taught a final-year mathematics course using craft. A part of most lectures included a hands-on craft activity to explore a key concept and to foster curiosity. This article describes the design and delivery of the course and reflects on the overwhelmingly positive student feedback. We suggest that the creation of, and interaction with, mathematical craft objects played a significant role in shaping these responses by generating feelings of engagement, reducing stress, and allowing tangible access to mathematical ideas.
- Published
- 2022
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150. The Experiences of African American Female Elementary School Principals in Southwest Georgia
- Author
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Wilson, Sharonda L.
- Abstract
Through the research conducted, the experiences of African American female principals in their efforts to become principals of K-12 schools in rural Southwest Georgia were revealed. The researcher sought to understand African American female principals' life experiences, perceived barriers, and strategies used on their journey to become principals. Qualitative research guided the researcher in capturing the narratives of six African American female educators who advanced to become principals of elementary schools in Southwest Georgia. The literature captured theories, information, and influences that aligned with the race and gender of the six African American female participants of this study. Some information found in the literature may have impacted or influenced some of the perceived barriers and strategies these African American females encountered on their journey to become elementary school principals in Southwest Georgia. The literature revealed the rationales to support African American females desiring to become principals. The significance of this study supports and encourages African American female educators who desire to become principals. There is a growing need for African American female educational leaders to serve as mentors and work to encourage other African American females to travel the same path they traveled. The study also provided information to school districts' personnel departments, college and university leadership programs, local RESAs, and the state department of education. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2022
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