931 results on '"Wilson, Michael D."'
Search Results
102. GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate
- Author
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Song, Mengyi, primary, Yuan, Xuefei, additional, Racioppi, Claudia, additional, Leslie, Meaghan, additional, Stutt, Nathan, additional, Aleksandrova, Anastasiia, additional, Christiaen, Lionel, additional, Wilson, Michael D., additional, and Scott, Ian C., additional
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- 2022
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103. Selective Sweeps and Genetic Lineages of Plasmodium falciparum Drug -Resistant Alleles in Ghana
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Alam, Md Tauqeer, de Souza, Dziedzom K., Vinayak, Sumiti, Griffing, Sean M., Poe, Amanda C., Duah, Nancy O., Ghansah, Anita, Asamoa, Kwame, Slutsker, Laurence, Wilson, Michael D., Barnwell, John W., Udhayakumar, Venkatachalam, and Koram, Kwadwo A.
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- 2011
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104. Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodium
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White, Bradley J., Lawniczak, Mara K. N., Cheng, Changde, Coulibaly, Mamadou B., Wilson, Michael D., Sagnon, N'Fale, Costantini, Carlo, Simard, Frederic, Christophides, George K., Besansky, Nora J., and Ayala, Francisco J.
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- 2011
105. Additional file 1 of Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland
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Hou, Huayun, Chan, Cadia, Yuki, Kyoko E., Sokolowski, Dustin, Roy, Anna, Qu, Rihao, Uusküla-Reimand, Liis, Faykoo-Martinez, Mariela, Hudson, Matt, Corre, Christina, Goldenberg, Anna, Zhang, Zhaolei, Palmert, Mark R., and Wilson, Michael D.
- Abstract
Additional file 1: Figure S1. Illustration of 3’UTR-seq method and quality control. A. Overview of the QuantSeq data analysis pipeline. B. Genome browser screenshot of extended 3’UTRs for genes Pou1f1 (left) and Ghrhr (right). Gene name and gene model are shown on the bottom of each panel. Each track represents overlapping signal from 5-6 biological replicates. C. Summary of qPCR vs. 3’UTR-seq comparisons across samples in all samples. Bottom panel: bar plots showing the numbers of genes detected using qPCR (white bars) and 3’UTR seq (red bars). The Spearman correlation coefficients between two experiments are shown for each sample in the dot plot (middle panel) and as well as in a density plot (top panel). Figure S2. Correlation heatmaps for pituitary gland samples. Pearson correlation between samples is calculated based on (A) gene expression and (B) miRNA expression. Hierarchical clustering is performed based on pairwise Pearson correlation coefficients (PCCs). Heatmap color intensity represents PCCs (orange: lower correlation; purple: higher correlation). Sample conditions are shown in top bars. Green shades: different ages, blue: male samples; red: female samples. Figure S3. Characterization of sex-biased mRNAs and miRNAs. A. Gene expression heatmap of sex-biased genes at PD12 and PD22, and genes with significant sex-by-age effect between PD12 and PD22. Each row represents a gene and each column represents a sample. Column annotation bars indicate sample age and sex. Colors represent row-scaled log2 (normalized counts). Whether a gene is female-biased (red) or male-biased (blue) at each corresponding age is summarized by the row annotation bars on the left. Sex chromosome-linked genes are labeled with asterisks. Genes with significant sex-by-age interaction effect between PD12 and PD22 are bolded. B. Expression plots of all sex-biased miRNAs. Log2(normCounts) are plotted for each miRNA across ages. Large filled points represent median expression at each age and unfilled points represent each biological replicate. Red: female samples; blue: male samples. C. novel46 is a mirtron of Cacna1g. The precursor of novel46 is expressed from the last intron of Cacna1g (highlighted in blue). The canonical seed region (nucleotide positions 2-8) in the mature sequence of novel46 is bolded. Figure S4. Summary of gene co-expression modules. Left panel. Module expression profile (log2-transformed normalized counts (log2(normCounts)) scaled per gene across all samples) is plotted for genes within each co-expression module across profiled postnatal ages. Dotted lines: individual gene profiles, solid line: median expression profile of module genes. Number of genes within each module is labeled at the top of the plots. Red: female samples; blue: male samples. Right panel. Expression profile of top five hub genes for each module. log2(normCounts) is plotted across profiled postnatal ages. Large, filled points represent median expression at each age and unfilled points represent each biological replicate. Blue: male samples; red: female samples. Figure S5. Characterization of co-expression gene modules. A. Correlation heatmap based on module eigengene (first PC, obtained using “mod_summary()” function from “CEMitool”). Color scale represents pairwise Pearson correlation coefficients. B. Barplots showing the eigengene for each sample in each module. Samples are grouped by age and colored by sex (blue: male; red: female). C. Barplots showing pathway enrichment results for genes in each module. Each bar represents a pathway. Color represents pathway categories (BP: Biological Process; CC: Cellular Component; MF: Molecular Function). Number of module genes in the pathway is labeled. X axis: -log10(P-value) of each pathway. Figure S6. Co-expression module gene enrichment in single-nuclei RNA-seq data. Uniform Manifold Approximation and Projection (UMAP) dimension reduction representation of adult female and male mouse pituitary gland single-nuclei transcriptome integrated by sex from Ruf-Zamojski et al. 2021 (A) colored by cell type and (B) colored by sample sex. Samples derived from snap-frozen pituitaries were first merged between replicates for each sex (n=3/sex). Merged samples were then integrated between sexes. C. Enrichment heatmap of co-expression module genes within cell types. One-sided Kolmogorov–Smirnov (KS) test was performed to test for enrichment of each co-expression module gene within a given cell type compared to all other cell types. Color gradient represents KS test FDR-adjusted P-value for each gene (dark purple: high enrichment; gray: low enrichment). Only genes with FDR ≤ 0.05 in at least one cell type are plotted and only FDR < 0.05 are shown. Each column represents a cell type as labeled at the bottom of the heatmap. Each row represents a co-expression module gene and the genes are grouped by the co-expression module in which the gene was identified (labeled on the right). Breaks were added in the heatmap between co-expression modules. Colored boxes represent the level of significance based on a one-sided hypergeometric test to determine if a group of module genes with KS test FDR ≤ 0.05 was significantly enriched for a given cell type. D. Estimated cell-type proportions by RNA-seq deconvolution using Proportions in Admixture (WGCNA) changes across profiled ages of pituitary cell types without known sex differences in their proportions. Estimated cell-type proportions are plotted across postnatal ages along the x-axis. Large circles and triangles represent the mean cell-type proportion at each age and small circles and triangles represent each biological replicate. Lighter color, solid line, circle points: female samples; dark color, dotted line, triangle points: male samples. Wilcoxon test was performed to compare cell proportions between both sexes at each age (*P
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- 2022
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106. Five-Vertebrate ChlP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding
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Schmidt, Dominic, Wilson, Michael D., Ballester, Benoit, Schwalie, Petra C., Brown, Gordon D., Marshall, Aileen, Kutter, Claudia, Watt, Stephen, Martinez-Jimenez, Celia P., Mackay, Sarah, Talianidis, Iannis, Flicek, Paul, and Odom, Duncan T.
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- 2010
107. Landscape Configuration Effects on Distribution and Abundance of Whip-Poor-Wills
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Wilson, Michael D. and Watts, Bryan D.
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- 2008
108. Species-Specific Transcription in Mice Carrying Human Chromosome 21
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Wilson, Michael D., Barbosa-Morais, Nuno L., Schmidt, Dominic, Conboy, Caitlin M., Vanes, Lesley, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Tavaré, Simon, and Odom, Duncan T.
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- 2008
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109. Breeding Range Extension of the Coastal Plain Swamp Sparrow
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Watts, Bryan D., Wilson, Michael D., Smith, Fletcher M., Paxton, Barton J., and Williams, J. Bill
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- 2008
110. Status Review of Chesapeake Bay Marsh Lands and Breeding Marsh Birds
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Wilson, Michael D., Watts, Bryan D., and Brinker, David F.
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- 2007
111. Molecular Structure-Based Screening of the Constituents of Calotropis procera Identifies Potential Inhibitors of Diabetes Mellitus Target Alpha Glucosidase
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Adinortey, Cynthia A., primary, Kwarko, Gabriel B., additional, Koranteng, Russell, additional, Boison, Daniel, additional, Obuaba, Issaka, additional, Wilson, Michael D., additional, and Kwofie, Samuel K., additional
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- 2022
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112. MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria
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Oxendine Harp, Keri, primary, Bashi, Alaijah, additional, Botchway, Felix, additional, Dei-Adomakoh, Yvonne, additional, Iqbal, Shareen A., additional, Wilson, Michael D., additional, Adjei, Andrew A., additional, Stiles, Jonathan K., additional, and Driss, Adel, additional
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- 2022
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113. Deep Neural Networks Predict Inhibitors ofSchistosoma MansoniThioredoxin Glutathione Reductase (SmTGR)
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Kwofie, Samuel K., primary, Agyenkwa-Mawuli, Kwasi, additional, Adams, Joseph, additional, Anteh, Phinehas, additional, Agyapong, Odame, additional, and Wilson, Michael D., additional
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- 2022
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114. Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland
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Hou, Huayun, primary, Chan, Cadia, additional, Yuki, Kyoko E, additional, Sokolowski, Dustin, additional, Roy, Anna, additional, Qu, Rihao, additional, Uuskula-Reimand, Liis, additional, Faykoo-Martinez, Mariela, additional, Hudson, Matt, additional, Corre, Christina, additional, Goldenberg, Anna, additional, Zhang, Zhaolei, additional, Palmert, Mark R, additional, and Wilson, Michael D, additional
- Published
- 2022
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115. Decline of Eastern Black Rails (Laterallus jamaicensis jamaicensis) within the Chesapeake Bay Region, USA
- Author
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Watts, Bryan D., primary, Brinker, David F., additional, Wilson, Michael D., additional, Smith, Fletcher M., additional, and Hines, Chance H., additional
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- 2021
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116. Alternative polyadenylation is a determinant of oncogenic Ras function
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Subramanian, Aishwarya, primary, Hall, Mathew, additional, Hou, Huayun, additional, Mufteev, Marat, additional, Yu, Bin, additional, Yuki, Kyoko E., additional, Nishimura, Haruka, additional, Sathaseevan, Anson, additional, Lant, Benjamin, additional, Zhai, Beibei, additional, Ellis, James, additional, Wilson, Michael D., additional, Daugaard, Mads, additional, and Derry, W. Brent, additional
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- 2021
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117. Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models
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Rodrigues, Deivid Carvalho, primary, Mufteev, Marat, additional, Yuki, Kyoko E, additional, Narula, Ashrut, additional, Wei, Wei, additional, Piekna, Alina, additional, Liu, Jiajie, additional, Pasceri, Peter, additional, Rissland, Olivia S, additional, Wilson, Michael D, additional, and Ellis, James, additional
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- 2021
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118. Effect of Moonlight on Detection of Whip-Poor-Wills: Implications for Long-Term Monitoring Strategies
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Wilson, Michael D. and Watts, Bryan D.
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- 2006
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119. BuDb: A Curated Drug Discovery Database for Buruli Ulcer.
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kwofie, Samuel K., Anyimadu, Daniel Tweneboah, Aryee, Solomon, Asare, Blessing, Kokroko, Natalie, Owusu, Jeffrey A., Afutu, Baron, Agyapong, Odame, Mosi, Lydia, Kyei-Baffour, Edwin, Enninful, Kweku S., Agoni, Clement, and Wilson, Michael D.
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DRUG discovery ,BURULI ulcer ,DATABASES ,PLANT genomes ,DRUG target - Abstract
Buruli ulcer (BU), a severe skin disease is caused by Mycobacterium ulcerans. There are concerns of therapeutic inefficacy of existing drugs coupled with chemoresistance. Databases have been shown to augment data mining and integrative systems pharmacology approaches towards the search for novel therapeutic moieties. So far, there is no known integrated database solely dedicated to BU drug discovery. In this work, Buruli ulcer database (BuDb) is a "one-stop-shop" knowledgebase for supporting BU drug discovery. It contains both manually verified literature and database-curated data on BU. The BuDb provides comprehensive information on the various drug targets, tested compounds, existing drugs, ethnopharmacological plants and information on the genome of M. ulcerans. It also contains cross-referenced links to databases including PubMed, PubChem, DrugBank, NCBI, Gene Ontology (GO), UniProt, Prota4u, String database, KEGG Pathway and KEGG genome database. The BuDb has been implemented with accessibility features such as keyword and specific searches as well as browsing. BuDb is the first useful online repository of its kind integrated with enriched datasets that can aid in the discovery of new biotherapeutic entities for BU. BuDb can be freely accessed at http://197.255.126.13:3000/. BuDb is the first online database that support the discovery of new biotherapeutic entities for Buruli ulcer. BuDb provides comprehensive information on the various drug targets, tested compounds, existing drugs and ethnopharmacological plants. BuDb is cross-referenced to functional genomic data, pathways and gene ontologies relating to Mycobacterium ulcerans. [ABSTRACT FROM AUTHOR]
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- 2023
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120. Sheep Models of F508del and G542X Cystic Fibrosis Mutations Show Cellular Responses to Human Therapeutics
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Périssé, Iuri Viótti, Fan, Zhiqiang, Van Wettere, Arnaud J, Liu, Ying, Leir, Shih-Hsing, Keim, Jacob, Regouski, Misha, Wilson, Michael D., Cholewa, Kelly M., Mansback, Sara N., Kelly, Thomas J., Wang, Zhongde, Harris, Ann, White, Kenneth L., Polejaeva, Irina A., and John Wiley & Sons, Inc.
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human drugs ,cloning ,Medicine and Health Sciences ,Diseases ,respiratory system ,CFTR ,CRISPR/Cas9 ,animal models - Abstract
Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The F508del and G542X are the most common mutations found in US patients, accounting for 86.4% and 4.6% of all mutations, respectively. The F508del causes deletion of the phenylalanine residue at position 508 and is associated with impaired CFTR protein folding. The G542X is a nonsense mutation that introduces a stop codon into the mRNA, thus preventing normal CFTR protein synthesis. Here, we describe the generation of CFTRF508del/F508del and CFTRG542X/G542X lambs using CRISPR/Cas9 and somatic cell nuclear transfer (SCNT). First, we introduced either F508del or G542X mutations into sheep fetal fibroblasts that were subsequently used as nuclear donors for SCNT. The newborn CF lambs develop pathology similar to CFTR−/− sheep and CF patients. Moreover, tracheal epithelial cells from the CFTRF508del/F508del lambs responded to a human CFTR (hCFTR) potentiator and correctors, and those from CFTRG542X/G542X lambs showed modest restoration of CFTR function following inhibition of nonsense-mediated decay (NMD) and aminoglycoside antibiotic treatments. Thus, the phenotype and electrophysiology of these novel models represent an important advance for testing new CF therapeutics and gene therapy to improve the health of patients with this life-limiting disorder.
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- 2021
121. Computational Study on Potential Novel Anti-Ebola Virus Protein VP35 Natural Compounds
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Darko, Louis K. S., primary, Broni, Emmanuel, additional, Amuzu, Dominic S. Y., additional, Wilson, Michael D., additional, Parry, Christian S., additional, and Kwofie, Samuel K., additional
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- 2021
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122. Development of a proteochemometric-based support vector machine model for predicting bioactive molecules of tubulin receptors
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Agyapong, Odame, primary, Miller, Whelton A., additional, Wilson, Michael D., additional, and Kwofie, Samuel K., additional
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- 2021
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123. Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals
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Shin, Jean, Bourdon, Celine, Bernard, Manon, Wilson, Michael D., Reischl, Eva, Waldenberger, Melanie, Ruggeri, Barbara, Schumann, Gunter, Desrivieres, Sylvane, Leemans, Alexander, Abrahamowicz, Michal, Leonard, Gabriel, Richer, Louis, Bouchard, Luigi, Gaudet, Daniel, Paus, Tomas, and Pausova, Zdenka
- Published
- 2015
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124. A novel locus of resistance to severe malaria in a region of ancient balancing selection
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Band, Gavin, Rockett, Kirk A., Spencer, Chris C.A., Kwiatkowski, Dominic P., Le, Quang Si, Clarke, Geraldine M., Kivinen, Katja, Leffler, Ellen M., Cornelius, Victoria, Conway, David J., Williams, Thomas N., Taylor, Terrie, Bojang, Kalifa A., Doumbo, Ogobara, Thera, Mahamadou A., Modiano, David, Sirima, Sodiomon B., Wilson, Michael D., Koram, Kwadwo A., Agbenyega, Tsiri, Achidi, Eric, Marsh, Kevin, Reyburn, Hugh, Drakeley, Chris, Riley, Eleanor, Molyneux, Malcolm, Jallow, Muminatou, Pinder, Margaret, Toure, Ousmane B., Konate, Salimata, Sissoko, Sibiri, Bougouma, Edith C., Mangano, Valentina D., Amenga-Etego, Lucas N., Ghansah, Anita K., Hodgson, Abraham V.O., Ansong, Daniel, Enimil, Anthony, Evans, Jennifer, Apinjoh, Tobias O., Macharia, Alexander, Ndila, Carolyne M., Newton, Charles, Peshu, Norbert, Uyoga, Sophie, Manjurano, Alphaxard, Kachala, David, Nyirongo, Vysaul, Mead, Daniel, Drury, Eleanor, Auburn, Sarah, Campino, Susana G., MacInnis, Bronwyn, Stalker, Jim, Gray, Emma, Hubbart, Christina, Jeffreys, Anna E., Rowlands, Kate, Mendy, Alieu, Craik, Rachel, Fitzpatrick, Kathryn, Molloy, Sile, Hart, Lee, Hutton, Robert, Kerasidou, Angeliki, and Johnson, Kimberly J.
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- 2015
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125. History: Issues to Resolve.
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Wilson, Michael D.
- Abstract
The article examines issues addressed by the British National Curriculum History Working Group concerning history instruction for students with disabilities. The working group's recommendations are summarized and assessed in regard to special educational needs. Potential problems are identified and suggestions for successful implementation such as greater flexibility with the guidelines are made. (DB)
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- 1990
126. Prediction of antischistosomal small molecules using machine learning in the era of big data
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Kwofie, Samuel K., primary, Agyenkwa-Mawuli, Kwasi, additional, Broni, Emmanuel, additional, Miller III, Whelton A., additional, and Wilson, Michael D., additional
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- 2021
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127. Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics
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Viotti Perisse, Iuri, primary, Fan, Zhiqiang, additional, Van Wettere, Arnaud, additional, Liu, Ying, additional, Leir, Shih‐Hsing, additional, Keim, Jacob, additional, Regouski, Misha, additional, Wilson, Michael D., additional, Cholewa, Kelly M., additional, Mansbach, Sara N., additional, Kelley, Thomas J., additional, Wang, Zhongde, additional, Harris, Ann, additional, White, Kenneth L., additional, and Polejaeva, Irina A., additional
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- 2021
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128. Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents
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Antounians, Lina, Catania, Vincenzo D., Montalva, Louise, Liu, Benjamin D., Hou, Huayun, Chan, Cadia, Matie, Andreea C., Tzabetakis, Areti, Li, Bo, Figueira, Rebeca L., da Costa, Karina M., Wong, Amy P., Mitchell, Robert, David, Anna L., Patel, Ketan, de Coppi, Paolo, Sbragia, Lourenco, Wilson, Michael D., Rossant, Janet, and Zani, Augusto
- Abstract
Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by decreased lung growth and maturation. The most common birth defect found in babies with pulmonary hypoplasia is congenital diaphragmatic hernia (CDH). Despite research and clinical advances, CDH babies still have high morbidity and mortality rates, which are directly related to the severity of lung underdevelopment. To date, there is no effective treatment that promotes fetal lung growth and maturation. Herein, we describe a stem cell-based approach that enhances fetal lung development via the administration of extracellular vesicles (EVs) derived from amniotic fluid stem cells (AFSCs). Using fetal rodent models of pulmonary hypoplasia (primary epithelial cells, organoids, explants, and in vivo), we demonstrated that AFSC-EV administration promotes branching morphogenesis and alveolarization, rescues tissue homeostasis, and stimulates epithelial cell and fibroblast differentiation. We confirmed this regenerative ability in human models of lung injury, where human AFSC-EVs obtained following good manufacturing practices restored pulmonary epithelial homeostasis. Investigating EV mechanism of action by tracking AFSC-EV cargo transfer, profiling EV protein and RNA content, and sequencing target lung epithelial cells, we found that AFSC-EV beneficial effects were exerted via the release of\ud RNA cargo. Particularly, miRNAs that regulate the expression of genes involved in lung development, such as the miR17~92 cluster and its paralogues, were highly enriched in AFSCEVs and were increased in AFSC-EV-treated primary lung epithelial cells compared to untreated cells. Our findings suggest that AFSC-EVs hold regenerative ability for underdeveloped fetal lungs, demonstrating potential for therapeutic application in patients with pulmonary hypoplasia.
- Published
- 2021
129. MACE: model based analysis of ChIP-exo
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Wang, Liguo, Chen, Junsheng, Wang, Chen, Uusküla-Reimand, Liis, Chen, Kaifu, Medina-Rivera, Alejandra, Young, Edwin J., Zimmermann, Michael T., Yan, Huihuang, Sun, Zhifu, Zhang, Yuji, Wu, Stephen T., Huang, Haojie, Wilson, Michael D., Kocher, Jean-Pierre A., and Li, Wei
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- 2014
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130. Susceptibility status of Anopheles gambiae sensu stricto (Diptera: Culicidae) to pyrethroid and carbamate insecticides in the Greater Accra region of Ghana, West Africa
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Adeniran, Tolu T., Brown, Charles A., Rogers, William, Wilson, Michael D., Appawu, Maxwell A., and Boakye, Daniel A.
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- 2009
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131. Impact of a Formal Research Committee on Respiratory Therapists’ Publications
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Miller, Andrew G, primary, Wilson, Michael D, additional, Davies, John D, additional, Gentile, Michael A, additional, Thalman, Janice J, additional, and MacIntyre, Neil R, additional
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- 2021
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132. Computational Identification of Potential Anti-Inflammatory Natural Compounds Targeting the p38 Mitogen-Activated Protein Kinase (MAPK): Implications for COVID-19-Induced Cytokine Storm
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Asiedu, Seth O., primary, Kwofie, Samuel K., additional, Broni, Emmanuel, additional, and Wilson, Michael D., additional
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- 2021
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133. Implicating extracellular vesicles inPlasmodium falciparumartemisinin resistance development
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Tandoh, Kwesi Z., primary, Wilson, Michael D., additional, Quashie, Neils B., additional, and Duah‐Quashie, Nancy O., additional
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- 2021
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134. Cytotaxonomy of Simulium soderense sp. nov. and a redescription of the ‘Kulfo’ form (Dunbar, 1969) of Simulium damnosum s.l. (Diptera: Simuliidae) as Simulium kulfoense sp. nov. in Ethiopia
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Hadis, Mamuye, Wilson, Michael D., Cobblah, Millicent A., and Boakye, Daniel A.
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- 2008
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135. A Molecular Modeling Approach to Identify Potential Antileishmanial Compounds Against the Cell Division Cycle (cdc)-2-Related Kinase 12 (CRK12) Receptor of Leishmania donovani
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Broni, Emmanuel, primary, Kwofie, Samuel K., additional, Asiedu, Seth O., additional, Miller, Whelton A., additional, and Wilson, Michael D., additional
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- 2021
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136. Pharmacophore-Guided Identification of Natural Products as Potential Inhibitors of Mycobacterium ulcerans Cystathionine γ-Synthase MetB
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Kwofie, Samuel K., primary, Dolling, Nigel N. O., additional, Donkoh, Emmanuel, additional, Laryea, Godwin M., additional, Mosi, Lydia, additional, Miller, Whelton A., additional, Adinortey, Michael B., additional, and Wilson, Michael D., additional
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- 2021
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137. Heart Enhancers: Development and Disease Control at a Distance
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Yuan, Xuefei, primary, Scott, Ian C., additional, and Wilson, Michael D., additional
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- 2021
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138. Ecological zones rather than molecular forms predict genetic differentiation in the malaria vector Anopheles gambiae s.s. in Ghana
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Yawson, Alexander E., Weetman, David, Wilson, Michael D., and Donnelly, Martin J.
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Malaria -- Research ,Malaria -- Genetic aspects ,Anopheles -- Genetic aspects ,Anopheles -- Research ,Genetic variation -- Research ,Gene flow -- Research ,Biological sciences - Abstract
The malaria mosquito Anopheles gambiae s.s. is rapidly becoming a model for studies on the evolution of reproductive isolation. Debate has centered on the taxonomic status of two forms (denoted M and S) within the nominal taxon identified by point mutations in the X-linked rDNA region. Evidence is accumulating that there are significant barriers to gene flow between these forms, but that the barriers are not complete throughout the entire range of their distribution. We sampled populations from across Ghana and southern Burkina Faso, West Africa, from areas where the molecular frowns occurred in both sympatry and allopatry. Neither Bayesian clustering methods nor [F.sub.ST]-based analysis of nficrosatellite data found differentiation between the M and S molecular forms, but revealed strong differentiation among different ecological zones, irrespective of M/S status and with no detectable effect of geographical distance. Although no M/S hybrids were found in the samples, admixture analysis detected evidence of contemporary interform gene flow, arguably most pronounced in southern Ghana where forms occur sympatrically. Thus, in the sampled area of West Africa, lack of differentiation between M and S forms likely reflects substantial introgression, and ecological barriers appear to be of greater importance in restricting gene flow.
- Published
- 2007
139. Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer
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van Eif, Vincent W W, Protze, Stephanie I, Bosada, Fernanda M, Yuan, Xuefei, Sinha, Tanvi, van Duijvenboden, Karel, Ernault, Auriane C, Mohan, Rajiv A, Wakker, Vincent, de Gier-de Vries, Corrie, Hooijkaas, Ingeborg B, Wilson, Michael D, Verkerk, Arie O, Bakkers, Jeroen, Boukens, Bastiaan J, Black, Brian L, Scott, Ian C, Christoffels, Vincent M, van Eif, Vincent W W, Protze, Stephanie I, Bosada, Fernanda M, Yuan, Xuefei, Sinha, Tanvi, van Duijvenboden, Karel, Ernault, Auriane C, Mohan, Rajiv A, Wakker, Vincent, de Gier-de Vries, Corrie, Hooijkaas, Ingeborg B, Wilson, Michael D, Verkerk, Arie O, Bakkers, Jeroen, Boukens, Bastiaan J, Black, Brian L, Scott, Ian C, and Christoffels, Vincent M
- Abstract
RATIONALE: The development and function of the pacemaker cardiomyocytes of the sinoatrial node (SAN), the leading pacemaker of the heart, are tightly controlled by a conserved network of transcription factors, including TBX3 (T-box transcription factor 3), ISL1 (ISL LIM homeobox 1), and SHOX2 (short stature homeobox 2). Yet, the regulatory DNA elements (REs) controlling target gene expression in the SAN pacemaker cells have remained undefined.OBJECTIVE: Identification of the regulatory landscape of human SAN-like pacemaker cells and functional assessment of SAN-specific REs potentially involved in pacemaker cell gene regulation.METHODS AND RESULTS: We performed Assay for Transposase-Accessible Chromatin using sequencing on human pluripotent stem cell-derived SAN-like pacemaker cells and ventricle-like cells and identified thousands of putative REs specific for either human cell type. We validated pacemaker cell-specific elements in the SHOX2 and TBX3 loci. CRISPR-mediated homozygous deletion of the mouse ortholog of a noncoding region with candidate pacemaker-specific REs in the SHOX2 locus resulted in selective loss of Shox2 expression from the developing SAN and embryonic lethality. Putative pacemaker-specific REs were identified up to 1 Mbp upstream of TBX3 in a region close to MED13L harboring variants associated with heart rate recovery after exercise. The orthologous region was deleted in mice, which resulted in selective loss of expression of Tbx3 from the SAN and (cardiac) ganglia and in neonatal lethality. Expression of Tbx3 was maintained in other tissues including the atrioventricular conduction system, lungs, and liver. Heterozygous adult mice showed increased SAN recovery times after pacing. The human REs harboring the associated variants robustly drove expression in the SAN of transgenic mouse embryos.CONCLUSIONS: We provided a genome-wide collection of candidate human pacemaker-specific REs, including the loci of SHOX2, TBX3, a
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- 2020
140. Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer
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Cardiologie onderzoek 2, Onderzoek, Circulatory Health, Medische Fysiologie, Van Eif, Vincent W.W., Protze, Stephanie I., Bosada, Fernanda M., Yuan, Xuefei, Sinha, Tanvi, Van Duijvenboden, Karel, Ernault, Auriane C., Mohan, Rajiv A., Wakker, Vincent, De Gier-De Vries, Corrie, Hooijkaas, Ingeborg B., Wilson, Michael D., Verkerk, Arie O., Bakkers, Jeroen, Boukens, Bastiaan J., Black, Brian L., Scott, Ian C., Christoffels, Vincent M., Cardiologie onderzoek 2, Onderzoek, Circulatory Health, Medische Fysiologie, Van Eif, Vincent W.W., Protze, Stephanie I., Bosada, Fernanda M., Yuan, Xuefei, Sinha, Tanvi, Van Duijvenboden, Karel, Ernault, Auriane C., Mohan, Rajiv A., Wakker, Vincent, De Gier-De Vries, Corrie, Hooijkaas, Ingeborg B., Wilson, Michael D., Verkerk, Arie O., Bakkers, Jeroen, Boukens, Bastiaan J., Black, Brian L., Scott, Ian C., and Christoffels, Vincent M.
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- 2020
141. Identification of TIA1 mRNA targets during human neuronal development
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Byres, Loryn P., primary, Mufteev, Marat, additional, Yuki, Kyoko E., additional, Wei, Wei, additional, Piekna, Alina, additional, Wilson, Michael D., additional, Rodrigues, Deivid C., additional, and Ellis, James, additional
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- 2021
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142. Cheminformatics-Based Identification of Potential Novel Anti-SARS-CoV-2 Natural Compounds of African Origin
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Kwofie, Samuel K., primary, Broni, Emmanuel, additional, Asiedu, Seth O., additional, Kwarko, Gabriel B., additional, Dankwa, Bismark, additional, Enninful, Kweku S., additional, Tiburu, Elvis K., additional, and Wilson, Michael D., additional
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- 2021
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143. Single-cell mapper (scMappR): using scRNA-seq to infer the cell-type specificities of differentially expressed genes
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Sokolowski, Dustin J, primary, Faykoo-Martinez, Mariela, additional, Erdman, Lauren, additional, Hou, Huayun, additional, Chan, Cadia, additional, Zhu, Helen, additional, Holmes, Melissa M, additional, Goldenberg, Anna, additional, and Wilson, Michael D, additional
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- 2021
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144. Malaria and irrigated crops, Accra, Ghana
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Klinkenberg, Eveline, McCall, P.J., Hastings, Ian M., Wilson, Michael D., Amerasinghe, Felix P., and Donnelly, Martin J.
- Subjects
Urban agriculture -- Health aspects ,Malaria -- Research ,Malaria -- Environmental aspects ,Accra, Ghana -- Environmental aspects ,Accra, Ghana -- Health aspects - Abstract
We investigated the prevalence of malaria and associated risk factors in children living in urban Ghana. Malaria prevalence was associated with low hemoglobin concentration, low socioeconomic status, and higher age. [...]
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- 2005
145. Hemoglobin Genotypes Modulate Inflammatory Response to Plasmodium Infection
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Harp, Keri Oxendine, primary, Botchway, Felix, additional, Dei-Adomakoh, Yvonne, additional, Wilson, Michael D., additional, Hood, Joshua L., additional, Adjei, Andrew A., additional, Stiles, Jonathan K., additional, and Driss, Adel, additional
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- 2020
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146. Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana
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Myers-Hansen, James L., primary, Abuaku, Benjamin, additional, Oyebola, Muyiwa K., additional, Mensah, Benedicta A., additional, Ahorlu, Collins, additional, Wilson, Michael D., additional, Awandare, Gordon, additional, Koram, Kwadwo A., additional, Ngwa, Alfred Amambua, additional, and Ghansah, Anita, additional
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- 2020
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147. GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate
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Song, Mengyi, primary, Yuan, Xuefei, additional, Racioppi, Claudia, additional, Leslie, Meaghan, additional, Aleksandrova, Anastasiia, additional, Christiaen, Lionel, additional, Wilson, Michael D., additional, and Scott, Ian C., additional
- Published
- 2020
- Full Text
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148. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De La Medina, Antonio, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, van Ramshorst, Gabrielle H, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Casteleins, William Augusto, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Martin, Janet, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Lee, Susan M, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Modolo, Maria Marta, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Olivos, Maricarmen, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Safi, Mohammed, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Christensen, Peter, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Asla, Amir Fathi, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Awad, Ahmed K, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Elbadawy, Merihan A, Ezzat, Rana 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Giuliana, Bernante, Paolo, Casadio, Paolo, Seracchioli, Renato, Droghetti, Matteo, Schiavina, Riccardo, Ricotta, Francesco, Tarsitano, Achille, Arena, Alessandro, Della Gatta, Anna Nunzia, Violante, Tommaso, Pellegrini, Alice, Bolognesi, Federico, Solli, Piergiorgio, Ricciardi, Sara, Cipolli, Alessandro, Maletta, Manuela, La Porta, Marilina, Lauretta, Maria Paola, Melotti, Rita M, Daddi, Niccolò, Parri, Sergio Nicola Forti, Garelli, Elena, Perrone, Anna M, Lombardi, Raffaele, Pinto, Valentina, Pignatti, Marco, Tonini, Valeria, Copelli, Chiara, Giordano, Antonio Nicola, Palai, Vincenzo, Aspide, Raffaele, La Corte, Emanuele, Lucchini, Stefano, Castagnini, Francesco, Pardo, Francesco, Di Liddo, Michele, Caternicchia, Filippo, Donati, Danilo, Cavalieri, Bruno, Frisoni, Tommaso, Rotini, Marco, Scabini, Stefano, Vagge, Aldo, Desideri, Lorenzo Ferro, Barra, Fabio, Sparavigna, Marco, Fregatti, Piero, Luzzi, Andrea-Pierre, Costantini, Sergio, Ferrero, Simone, Gustavino, Claudio, Paratore, Marco, Perrone, Umberto, Centurioni, Maria Grazia, Alessandri, Franco, Ferraiolo, Antonella, Rosato, Francesco Paolo, Ball, Lorenzo, Ascari, Francesca, Barugola, Giuliano, Lovece, Andrea, Milito, Pamela, Siboni, Stefano, Bonavina, Luigi, Aiolfi, Alberto, Bona, Davide, Micheletto, Giancarlo, Bertolaccini, Luca, Sedda, Giulia, Spaggiari, Lorenzo, Tagliabue, Marta, De Berardinis, Rita, Pietrobon, Giacomo, Chu, Francesco, reAnsarin, Mohssen, Garbi, Annalisa, Patrone, Renato, Belli, Andrea, Cianci, Pasquale, Raimondo, Ivano, Ferrero, Annamaria, Pacilio, Carlo Alberto, Bocchino, Antonio, Solaini, Leonardo, D'Acapito, Fabrizio, Di Stefano, Barbara, Corso, Ruggero M, Pata, Francesco, Vitale, Mariarosaria, Rotunno, Giuseppe, Lenzi, Riccardo, Migliorino, Ernesto, Grossi, Ugo, Novello, Simone, Romano, Maurizio, Rossi, Serena, Zanus, Giacomo, Epifani, Angelo G, Broglia, Alessandro, Santoliquido, Matteo, Clementi, Marco, Marafante, Chiara, Carrano, Francesco Maria, Patrone, Renato, Fleres, Francesco, Clarizia, Guglielmo, Coretti, Guido, Ferrario, Luca, Guerci, Claudio, Maffioli, Anna, D'Andrea, Marcello, Zanini, Nicola, Bertelli, Riccardo, Vallicelli, Carlo, Catena, Fausto, Prucher, Gian Marco, Conti, Alfredo, Moretto, Gianluigi, Inama, Marco, Grivon, Manuela, Sambucci, Daniele, Pirola, Giacomo M, Gubbiotti, Marilena, Sagnotta, Andrea, Ornaghi, Sara, Fruscio, Robert, Tamini, Nicolò, Ceresoli, Marco, Gianotti, Luca, Masciello, Fabrizio, Nelli, Tommaso, Canonico, Giuseppe, Anastasi, Alessandro, Malerba, Michele, Abate, Emmanuele, Lizzi, Vincenzo, Sarni, Antonio L, Tartaglia, Nicola, Montagna, Marco, D'Ugo, Stefano, Depalma, Norma, Spampinato, Marcello, Pizzini, Paolo, Magnone, Stefano, Migliore, Marcello, Volpicelli, Alessio, Gioco, Rossella, Russo, Giorgio Ivan, Bozzani, Antonio, Cobianchi, Lorenzo, Calabretto, Francesca, Pinotti, Enrico, Barone, Mirko, Campanelli, Michela, Bagaglini, Giulia, Siragusa, Leandro, Orecchia, Luca, Franceschilli, Marzia, Angelico, Roberta, Sensi, Bruno, Manzia, Tommaso M, Petagna, Lorenzo, Bacchiocchi, Giulia, Sica, Giuseppe S, Lapolla, Pierfrancesco, Picchetto, Andrea, Bruzzaniti, Placido, Marruzzo, Giovanni, Sterpetti, Antonio V, Mingoli, Andrea, Sapienza, Paolo, Scafa, Anthony Kevin, Zancana, Giuseppa, Brachini, Gioia, Ribuffo, Diego, Cirillo, Bruno, Meneghini, Simona, Cicerchia, Pierfranco M, Zambon, Martina, D'Andrea, Vito, D'Amico, Alessia, Familiari, Pietro, Cassoni, Andrea, Pucci, Resi, De Felice, Francesca, Pascarella, Giuseppe, Strumia, Alessandro, Coppola, Alessandro, Zampogna, Biagio, Papalia, Rocco, Capolupo, Gabriella T, Caricato, Marco, Nenna, Antonio, Dominici, Carmelo, Caffo, Maria, Badessi, Giorgio, Mazzeo, Carmelo, Caruso, Gerardo, Bellio, Gabriele, Guaitoli, Eleonora, Rimonda, Roberto, Fusini, Federico, Giacometti, Marco, Baldi, Caterina, Ferrara, Francesco, Chessa, Antonella, Accarino, Giulio, Monteleone, Michela, Riva, Carlo, Balconi, Arianna, Markovic, Marko, Barone, Gisella, Locatelli, Andrea, Olmetti, Simone, Costanzi, Andrea, Uccelli, Matteo, Galleano, Raffaele, Balla, Andrea, De Carlo, Antonio, Ceretti, Andrea Pisani, Bertoglio, Luca, Grandi, Alessandro, Apruzzi, Luca, Melloni, Andrea, Spartalis, Michael, Spina, Alfio, De Nardi, Paola, Bonavina, Giulia, Candiani, Massimo, Piloni, Martina, Nocera, Gianluca, Gagliardi, Filippo, Turi, Stefano, De Nunzio, Cosimo, Petrucciani, Niccolo, Fiorelli, Silvia, Laracca, Giovanni G, Menna, Cecilia, Lisi, Giorgio, Brolese, Alberto, Ciarleglio, Francesco A, Sasia, Diego, Giraudo, Giorgio, Testa, Valentina, Giuffrida, Maria Carmela, Chiarpenello, Roberto, Dalmasso, Ettore, Cianflocca, Desiree, Calini, Giacomo, Cillara, Nicola, Armatura, Giulia, Turati, Luca, Pellino, Gianluca, Menna, Maria Paola, Iovino, Claudio, Rossi, Settimio, Simonelli, Francesca, Baccellieri, Domenico, Candiani, Massimo, Gozzini, Lorenzo, Elmore, Ugo, Rosati, Riccardo, Gallo, Gaetano, Giannaccare, Giuseppe, Cristofaro, Maria G, Barca, Ida, Carnevali, Adriano, Consorti, Giuseppe, Laganà, Antonio Simone, Pontini, Alex, Salvador, Renato, Di Marzo, Francesco, Turri, Giulia, Saito, Junichi, Kochiyama, Tsukasa, Satoi, Sohei, Hashimoto, Daisuke, Yoshimatsu, Kazuhiko, Namikawa, Tsutomu, Kuriyama, Akira, Sunami, Eiji, Takeda, aChikashi, Shiota, Masaki, Toyama, Satoshi, Ishitobi, Makoto, Kawasaki, Yosuke, Kawaguchi, Masahiko, Ida, Mitsuru, Iwasaki, Masae, Mase, Hiroshi, Fujimoto, Yuki, Chaki, Tomohiro, Tachibana, Shunsuke, Kazuma, Satoshi, Kuroda, Naoto, Matsuki, Yuka, Kamizato, Kota, Omari, Rand Y, Salim, Mohammad Ahmad Jamil Es, Alwarawrah, Zaid, AAbdulrahmanlarood, Salameh A, Alnaser, Adnan R, Alhusseini, Radi Tofaha, Qasem, Abdulrahman G, Eid, Ahmad M, Theab, Mohammad A, Ghayada, Ibrahim, Guboug, Ali, Alqedrh, Mohannad Fayiz, Al-banna, Mohammed E, Abuleil, Amro, Asassfeh, Yaqin Mahmoud, ali, Zaid Mohammed Al-sheikh, Eid, Ahmad Ayman, AbuSalah, Reem G, Hijazeen, Raid George, Awadi, Sajeda, Mansour, Omar S, Khamees, Almu'atasim, Alrayes, Bourhan, Hassan, Mohammad, Qandeel, Mahmoud W M, Ibrahim, Zainab O, Salah, Mohammad Maher Salah, Alnatour, Hazem Zuhair, Saleh, Ma'moun Helmi Suleiman, Suradi, Haya H, Abu Serhan, Hashem A, Abu Za'nouneh, Faris Jamal, Alheji, Hazim R, Al-Shami, Khayry, Mousa, Ala'a Al-deen T, Bsisu, Isam K, Bsisu, Rasha, Abuzenah, Mohammad I A, Kalaji, Zeina H, Jabaiti, Samir, Omeish, Haya A, Almuhtaseb, Aseel Y, Abuleil, Amro M, Theab, Reem A, Sheyyab, Anagheem A, Hamouri, Shadi, Ababneh, Hazim S, Amarin, Zouhair, Bahhour, Mohammad Yasin, Abu-Mehsen, Marah K, Al-howthi, Mohammed Abdullah, Wafi, Omar S S, Sawadi, Taher Rashed Mohammed, Albustami, Iyad S, Masadeh, Maen O, Al Khassawneh, Ahmad, Amarin, Justin Z, Irshaidat, Sara S, Abou Chaar, Mohamad K, Zaghlol, Louay Y, Mansour, Razan, Shahait, Mohammed, Qandeel, Haitham, Abd Almonem, B, Hawasly, Lubna, Alsabbagh, Ghalia, Al-Dabaa, Tawfik Mohammed, Amer, Qaed Mashhour Bani, Abu-Ismail, Luai, Shaout, Dua'a M, Abu-shadouf, Tariq H, Bolatbekova, Raikhan, Issayev, 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Bahaeddin, Alkimeeshi, Nayrouz, Marwan, Malak, Muhammed, Nawal Aldokali, Benamer, Eman M, Othman, Rema H, Momen, Ahmed A, Ayad, Kusay A, Aldokali, Nawal, Mohammed, Alsnosy Abdullah Khalefa, Sanousi, Enas F, Aboubakr, Saed J, Aboubakr, Islam F, Alttaira, Amal, Benatiga, Sara A, Alteerah, Ilham A, Aldressi, Wafa, Elhwety, Marwa O, Kalifa, Mohamed Fathi, Glessa, Maram A, Abubaker, Taha, Shembesh, Hassan A, Alansari, Arowa, Alkaseek, Akram M, Abusannuga, Malek Mohamed, Alawami, Mohammed A, Elhajdawe, Fras Ammar, Benamwor, Aihab Salem, Aween, Husayn M, Kriem, Eslam, Al Islam Benjouira, Rayet, Shagour, Sana Moussa, Ali, Hajar Alamin, Awrayit, Ahmed I, Matoug, Salmin Ibrahim, Abdesalam, Rema Ibrahim, Ouakouak, Ikhlas M, Aldarraji, Ali H, Elmahdi, Ameerah Faraj, Mohamed, Zinelabedin, Khan, Samera M, Gerwash, Ahmed A, Aboubeirah, Mohammed Khayri, Drera, Nosaiba Jalal, Sinan, Marwa A, Abujrad, Ekram Abdulhamid, Biala, Marwa, Gidiem, Doaa A, Aljamal, Sarah A, Hamuda, Esmail M, Manhus, Hussamuddin 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Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
- Abstract
The 2015 LancetCommission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
- Published
- 2022
- Full Text
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149. Biallelic loss-of-function variants in RABGAP1cause a novel neurodevelopmental syndrome
- Author
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Oh, Rachel Youjin, Deshwar, Ashish R., Marwaha, Ashish, Sabha, Nesrin, Tropak, Michael, Hou, Huayun, Yuki, Kyoko E., Wilson, Michael D., Rump, Patrick, Lunsing, Roelineke, Elserafy, Noha, Chung, Clara W.T., Hewson, Stacy, Klein-Rodewald, Tanja, Calzada-Wack, Julia, Sanz-Moreno, Adrián, Kraiger, Markus, Marschall, Susan, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Dowling, James, and Schulze, Andreas
- Abstract
RABGAP1 is a GTPase-activating protein implicated in a variety of cellular and molecular processes, including mitosis, cell migration, vesicular trafficking, and mTOR signaling. There are no known Mendelian diseases caused by variants in RABGAP1.
- Published
- 2022
- Full Text
- View/download PDF
150. Targeting the Plasmodium falciparum 's Thymidylate Monophosphate Kinase for the Identification of Novel Antimalarial Natural Compounds.
- Author
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Enninful, Kweku S., Kwofie, Samuel K., Tetteh-Tsifoanya, Mark, Lamptey, Amanda N. L., Djameh, Georgina, Nyarko, Samuel, Ghansah, Anita, and Wilson, Michael D.
- Subjects
PLASMODIUM falciparum ,DNA replication ,ARTEMISIA annua ,BINDING energy ,NATURAL products - Abstract
Recent reports of resistance to artemisinin-based combination drugs necessitate the need to discover novel antimalarial compounds. The present study was aimed at identifying novel antimalarial compounds from natural product libraries using computational methods. Plasmodium falciparum is highly dependent on the pyrimidine biosynthetic pathway, a de novo pathway responsible for the production of pyrimidines, and the parasite lacks the pyrimidine salvage enzymes. The P. falciparum thymidylate monophosphate kinase (Pf TMPK) is an important protein necessary for rapid DNA replication; however, due to its broad substrate specificity, the protein is distinguished from its homologs, making it a suitable drug target. Compounds from AfroDB, a database of natural products originating from Africa, were screened virtually against Pf TMPK after filtering the compounds for absorption, distribution, metabolism, excretion, and toxicity (ADMET)-acceptable compounds with FAF-Drugs4. Thirteen hits with lower binding energies than thymidine monophosphate were selected after docking. Among the thirteen compounds, ZINC13374323 and ZINC13365918 with binding energies of −9.4 and −8.9 kcal/mol, respectively, were selected as plausible lead compounds because they exhibited structural properties that ensure proper binding at the active site and inhibitory effect against Pf TMPK. ZINC13374323 (also called aurantiamide acetate) is known to exhibit anti-inflammatory and antiviral activities, and ZINC13365918 exhibits antileishmanial activity. Furthermore, aurantiamide acetate, which is commercially available, is a constituent of Artemisia annua , the herb from which artemisinin was derived. The compound also shares interactions with several residues with a potent thymidine analog inhibitor of Pf TMPK. The anti-plasmodial activity of aurantiamide acetate was evaluated in vitro , and the mean half-maximal inhibitory concentration (IC
50 ) was 69.33 μM when synchronized P. falciparum 3D7 culture was used as compared to IC50 > 100 μM with asynchronized culture. The significance of our findings within the context of malaria treatment strategies and challenges is discussed. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
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