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1,591 results on '"Westendorp, Rudi G."'

103. Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women:A Pooled Analysis Including 15 Study Populations

Author

Beenakker, Karel G M, Westendorp, Rudi G J, de Craen, Anton J M, Chen, Sijia, Raz, Yotam, Ballieux, Bart E P B, Nelissen, Rob G H H, Later, Alexander F L, Huizinga, Tom W, Slagboom, Pieternella E, Boomsma, Dorret I, Maier, A. B., Beenakker, Karel G M, Westendorp, Rudi G J, de Craen, Anton J M, Chen, Sijia, Raz, Yotam, Ballieux, Bart E P B, Nelissen, Rob G H H, Later, Alexander F L, Huizinga, Tom W, Slagboom, Pieternella E, Boomsma, Dorret I, and Maier, A. B.

Abstract

The incidence of bacterial infections and sepsis, as well as the mortality risk from sepsis, is sex specific. These clinical findings have been attributed to sex differences in immune responsiveness. The aim of the present study was to investigate sex differences in monocyte-derived cytokine production response upon stimulation with the gram-negative stimulus lipopolysaccharide (LPS) using cytokine data from 15 study populations. Individual data on ex vivo cytokine production response upon stimulation with LPS in whole blood were available for 4,020 subjects originating from these 15 study populations, either from the general population or from patient populations with specific diseases. Men had a stronger cytokine production response than women to LPS for tumour necrosis factor-α, interleukin (IL)-6, IL-12, IL-1β, IL-1RA, and IL-10, but not for interferon-γ. The granulocyte-macrophage colony-stimulating factor production response was lower in men than in women. These sex differences were independent of chronological age. As men had higher monocyte concentrations, we normalized the cytokine production responses for monocyte concentration. After normalization, the sex differences in cytokine production response to LPS disappeared, except for IL-10, for which the production response was lower in men than in women. A sex-based approach to interpreting immune responsiveness is crucial.

Published
2020

104. Onset of Workplace Bullying and Risk of Weight Gain : A Multicohort Longitudinal Study

Author

Xu, Tianwei, Magnusson Hanson, Linda L., Clark, Alice J., Ersbøll, Annette K., Westerlund, Hugo, Madsen, Ida E. H., Rugulies, Reiner, Pentti, Jaana, Stenholm, Sari, Vahtera, Jussi, Sørensen, Jeppe K., Nordentoft, Mads, Westendorp, Rudi G. J., Hansen, Åse M., Oksanen, Tuula, Virtanen, Marianna, Kivimäki, Mika, H. Rod, Naja, Xu, Tianwei, Magnusson Hanson, Linda L., Clark, Alice J., Ersbøll, Annette K., Westerlund, Hugo, Madsen, Ida E. H., Rugulies, Reiner, Pentti, Jaana, Stenholm, Sari, Vahtera, Jussi, Sørensen, Jeppe K., Nordentoft, Mads, Westendorp, Rudi G. J., Hansen, Åse M., Oksanen, Tuula, Virtanen, Marianna, Kivimäki, Mika, and H. Rod, Naja

Abstract

Objective: This study aimed to examine the onset of workplace bullying as a risk factor for BMI increase. Methods: Repeated biennial survey data from three Nordic cohort studies were used, totaling 46,148 participants (67,337 participant observations) aged between 18 and 65 who did not have obesity and who were not bullied at the baseline. Multinomial logistic regression was applied for the analysis under the framework of generalized estimating equations. Results: Five percent reported onset of workplace bullying within 2 years from the baseline. In confounder-adjusted models, onset of workplace bullying was associated with a higher risk of weight gain of >= 1 BMI unit (odds ratio = 1.09; 95% CI: 1.01-1.19) and of >= 2.5 BMI units (odds ratio = 1.24; 95% CI: 1.06-1.45). A dose-response pattern was observed, and those exposed to workplace bullying more frequently showed a higher risk (P-trend = 0.04). The association was robust to adjustments, restrictions, stratifications, and use of relative/absolute scales for BMI change. Conclusions: Participants with exposure to the onset of workplace bullying were more likely to gain weight, a possible pathway linking workplace bullying to increased long-term risk of type 2 diabetes.

Published
2020
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105. Circulating Thyroid Hormone Profile in Response to a Triiodothyronine Challenge in Familial Longevity

Author

Zutinic, Ana, Blauw, Gerard J., Pijl, Hanno, Ballieux, Bart E., Westendorp, Rudi G. J., Roelfsema, Ferdinand, van Heemst, Diana, Zutinic, Ana, Blauw, Gerard J., Pijl, Hanno, Ballieux, Bart E., Westendorp, Rudi G. J., Roelfsema, Ferdinand, and van Heemst, Diana

Abstract

Context Familial longevity is associated with higher circulating levels of thyrotropin (TSH), in the absence of differences in circulating thyroid hormones, and a lower thyroid responsivity to TSH, as previously observed in the Leiden Longevity Study (LLS). Further mechanisms underlying these observations remain unknown. Objective We hypothesized that members from long-lived families (offspring) have higher thyroid hormone turnover or less negative feedback effect on TSH secretion compared to controls. Methods In a case-control intervention study, 14 offspring and 13 similarly aged controls received 100 µg 3,5,3′-triiodothyronine (T3) orally. Their circulating T3, free T3 (fT3), and TSH levels were measured during 5 consecutive days. We compared profiles of circulating T3, fT3, and TSH between offspring and controls using general linear modeling (GLM) and calculated the percentage decline in TSH following T3 administration. Results Circulating T3 and fT3 levels increased to supraphysiologic values and normalized over the course of 5 days. There were no serious adverse events. T3 and fT3 concentration profiles over 5 days were similar between offspring and controls (T3 GLM P = .11, fT3 GLM P = .46). TSH levels decreased in a biphasic manner and started returning to baseline by day 5. The TSH concentration profile over 5 days was similar between offspring and controls (GLM P = .08), as was the relative TSH decline (%). Conclusions Members of long-lived families have neither higher T3 turnover nor diminished negative feedback of T3 on TSH secretion. The cause and biological role of elevated TSH levels in familial longevity remain to be elucidated.

Published
2020

106. Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone

Author

Zutinic, Ana, Pijl, Hanno, Ballieux, Bart E, Roelfsema, Ferdinand, Westendorp, Rudi G J, Blauw, Gerard J, van Heemst, Diana, Zutinic, Ana, Pijl, Hanno, Ballieux, Bart E, Roelfsema, Ferdinand, Westendorp, Rudi G J, Blauw, Gerard J, and van Heemst, Diana

Abstract

CONTEXT: Longevity is associated with higher circulating levels of TSH in the absence of differences in circulating thyroid hormones (TH), as previously observed in F2 members of long-lived families (F2-LLS) and their partners (F2-Con). The mechanism underlying this observed difference remains unknown.OBJECTIVE: We hypothesized that the thyroid gland of members from long-lived families are less responsive to TSH stimulation, thereby requiring higher circulating TSH levels to maintain adequate TH levels.METHODS: We performed a case-control intervention study with a single intramuscular (gluteal) injection with 0.1 mg recombinant human TSH in a subgroup of 14 F2-LLS and 15 similarly aged F2-Con. They were followed for 4 days. No serious adverse events were reported. For analyses, we compared time trajectories of TSH and TH, and the ratio of TH to TSH using area under the curve (AUC) calculations.RESULTS: The AUC free T4/AUC TSH ratio was significantly lower in F2-LLS than in F2-Con (estimated mean [95% confidence interval] 1.6 [1.2-1.9] and 2.2 [1.9-2.6], respectively, P = 0.01). The AUC thyroglobulin/AUC TSH ratio was also lower in F2-LLS than in F2-Con (median [interquartile range] 2.1 [1.4-3.6] and 3.2 [2.7-7.4], respectively, P = 0.04). We observed the same trend with the AUC free T3/AUC TSH ratio, although the difference was not statistically significant (estimated mean [95% confidence interval] 0.6 [0.4-0.7] and 0.7 [0.6-0.8], respectively, P = 0.07).CONCLUSIONS: The present findings show that members of long-living families have a lower thyroid responsivity to TSH compared with their partners.

Published
2020

107. Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

Author

van der Spoel, Evie, Roelfsema, Ferdinand, Akintola, Abimbola A., Jansen, Steffy W., Slagboom, P. Eline, Westendorp, Rudi G. J., Blauw, Gerard J., Pijl, Hanno, van Heemst, Diana, van der Spoel, Evie, Roelfsema, Ferdinand, Akintola, Abimbola A., Jansen, Steffy W., Slagboom, P. Eline, Westendorp, Rudi G. J., Blauw, Gerard J., Pijl, Hanno, and van Heemst, Diana

Published
2020

108. Perceived stress and dementia:Results from the Copenhagen city heart study

Author

Nabe-Nielsen, Kirsten, Rod, Naja Hulvej, Hansen, Ase Marie, Prescott, Eva, Grynderup, Matias Brødsgaard, Islamoska, Sabrina, Ishtiak-Ahmed, Kazi, Garde, Anne Helene, Gyntelberg, Finn, Mortensen, Erik Lykke, Thien Kieu Thi Phung, Waldemar, Gunhild, Westendorp, Rudi G. J., Nabe-Nielsen, Kirsten, Rod, Naja Hulvej, Hansen, Ase Marie, Prescott, Eva, Grynderup, Matias Brødsgaard, Islamoska, Sabrina, Ishtiak-Ahmed, Kazi, Garde, Anne Helene, Gyntelberg, Finn, Mortensen, Erik Lykke, Thien Kieu Thi Phung, Waldemar, Gunhild, and Westendorp, Rudi G. J.

Published
2020

114. Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes

Author

Flier, Wiesje M., Buchem, Mark A., Weverling-Rijnsburger, Annelies W. E., Mutsaers, Elisabeth R., Bollen, Eduard L. E. M., Admiraal-Behloul, Faiza, Westendorp, Rudi G. J., and Middelkoop, Huub A. M.

Subjects
Alzheimer's disease -- Health aspects, Alzheimer's disease -- Research, Hippocampus (Brain) -- Research, Magnetic resonance imaging -- Usage, Memory, Disorders of -- Research, Health
Abstract

Byline: Wiesje M. Flier (4), Mark A. Buchem (1), Annelies W. E. Weverling-Rijnsburger (2), Elisabeth R. Mutsaers (4), Eduard L. E. M. Bollen (4), Faiza Admiraal-Behloul (3), Rudi G. J. Westendorp (2), Huub A. M. Middelkoop (4) Keywords: hippocampus; Magnetic Resonance Imaging; cognition; memory loss; Alzheimer's disease Abstract: Abstract. We aimed to investigate volumetry of the medial temporal lobe in patients with subjective memory complaints without any cognitive impairment. This study included 20 patients with subjective memory complaints and normal cognitive function and 28 controls without memory complaints. Volumes of the hippocampus and parahippocampal gyrus (PHG) were measured using coronal T1-weighted MR images. Cognitive functions were assessed using the Cambridge Cognitive Examination. Depressive symptoms were assessed using the Geriatric Depression Scale. Differences between groups were analysed using t-tests. Patients with subjective memory complaints had a higher education and more depressive symptoms than controls (p &lt 0.01). Moreover, they had smaller left hippocampal volumes than controls (p &lt 0.01). There were no differences between groups in the volume of the right hippocampus or PHG. There was a moderate association between the volume of left hippocampus and left PHG and memory-score (r = 0.32, p = 0.03 r = 0.34, p = 0.02). We concluded that memory complaints in patients without any cognitive impairment were associated with smaller left hippocampal volumes and more depressive symptoms. These preliminary results suggest that memory complaints may reflect minimal brain deficits associated with impending dementia, depression or a combination of both disorders. Author Affiliation: (1) Dept. of Radiology, Leiden University Medical Center, Leiden, The Netherlands (2) Section of Gerontology and Geriatrics, Dept. of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands (3) Section of Image processing (LKEB), Dept. of Radiology, Leiden University Medical Center, Leiden, The Netherlands (4) Dept. of Neurology, J3R-43 Leiden University Medical Center, 9600, 2300, RC Leiden, The Netherlands Article History: Registration Date: 01/01/2004 Received Date: 24/09/2003 Accepted Date: 08/12/2003

Published
2004

122. Subclinical Hyperthyroidism and the Risk of Coronary Heart Disease and Mortality

Author

Collet, Tinh-Hai, Gussekloo, Jacobijn, Bauer, Douglas C., den Elzen, Wendy P., Cappola, Anne R., Balmer, Philippe, Iervasi, Giorgio, Åsvold, Bjørn O., Sgarbi, José A., Völzke, Henry, Gencer, Bariş, Maciel, Rui M., Molinaro, Sabrina, Bremner, Alexandra, Luben, Robert N., Maisonneuve, Patrick, Cornuz, Jacques, Newman, Anne B., Khaw, Kay-Tee, Westendorp, Rudi G., Franklyn, Jayne A., Vittinghoff, Eric, Walsh, John P., and Rodondi, Nicolas

Published
2012
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129. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

Author

Deelen, Joris, Beekman, Marian, Uh, Hae-Won, Helmer, Quinta, Kuningas, Maris, Christiansen, Lene, Kremer, Dennis, van der Breggen, Ruud, Suchiman, Eka H. D., Lakenberg, Nico, van den Akker, Erik B., Passtoors, Willemijn M., Tiemeier, Henning, van Heemst, Diana, de Craen, Anton J., Rivadeneira, Fernando, de Geus, Eco J, Perola, Markus, van der Ouderaa, Frans J., Gunn, David A., Boomsma, Dorret I., Uitterlinden, André G., Christensen, Kaare, van Duijn, Cornelia M., Heijmans, Bastiaan T., Houwing-Duistermaat, Jeanine J., Westendorp, Rudi G. J., and Slagboom, Eline P.

Published
2011
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133. Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

Author

Pons, Douwe, Trompet, Stella, de Craen, Anton J M, Thijssen, Peter E, Quax, Paul H A, de Vries, Margreet R, Wierda, Rutger J, van den Elsen, Peter J, Monraats, Pascalle S, Ewing, Mark M, Heijmans, Bastiaan T, Slagboom, P Eline, Zwinderman, Aeilko H, Doevendans, Pieter A F M, Tio, René A, de Winter, Robbert J, de Maat, Moniek P M, Iakoubova, Olga A, Sattar, Naveed, Shepherd, Jim, Westendorp, Rudi G J, and Jukema, J Wouter

Published
2011
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135. Onset of Workplace Bullying and Risk of Weight Gain: A Multicohort Longitudinal Study

Author

Xu, Tianwei, primary, Magnusson Hanson, Linda L., additional, Clark, Alice J., additional, Ersbøll, Annette K., additional, Westerlund, Hugo, additional, Madsen, Ida E. H., additional, Rugulies, Reiner, additional, Pentti, Jaana, additional, Stenholm, Sari, additional, Vahtera, Jussi, additional, Sørensen, Jeppe K., additional, Nordentoft, Mads, additional, Westendorp, Rudi G. J., additional, Hansen, Åse M., additional, Oksanen, Tuula, additional, Virtanen, Marianna, additional, Kivimäki, Mika, additional, and Rod, Naja H., additional

Published
2020
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136. Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Author

Chen, Sijia, primary, Pawelec, Graham, additional, Trompet, Stella, additional, Goldeck, David, additional, Mortensen, Laust H, additional, Slagboom, P Eline, additional, Christensen, Kaare, additional, Gussekloo, Jacobijn, additional, Kearney, Patricia, additional, Buckley, Brendan M, additional, Ford, Ian, additional, Jukema, J Wouter, additional, Westendorp, Rudi G J, additional, and Maier, Andrea B, additional

Published
2020
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141. Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality

Author

Rodondi, Nicolas, den Elzen, Wendy P., Bauer, Douglas C., Cappola, Anne R., Razvi, Salman, Walsh, John P., Åsvold, Bjørn O., Iervasi, Giorgio, Imaizumi, Misa, Collet, Tinh-Hai, Bremner, Alexandra, Maisonneuve, Patrick, Sgarbi, José A., Khaw, Kay-Tee, Vanderpump, Mark P., Newman, Anne B., Cornuz, Jacques, Franklyn, Jayne A., Westendorp, Rudi G., Vittinghoff, Eric, and Gussekloo, Jacobijn

Published
2010

145. A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

Author

Newman, Anne B., Walter, Stefan, Lunetta, Kathryn L., Garcia, Melissa E., Slagboom, P. Eline, Christensen, Kaare, Arnold, Alice M., Aspelund, Thor, Aulchenko, Yurii S., Benjamin, Emelia J., Christiansen, Lene, DʼAgostino, Ralph B., Sr, Fitzpatrick, Annette L., Franceschini, Nora, Glazer, Nicole L., Gudnason, Vilmundur, Hofman, Albert, Kaplan, Robert, Karasik, David, Kelly-Hayes, Margaret, Kiel, Douglas P., Launer, Lenore J., Marciante, Kristin D., Massaro, Joseph M., Miljkovic, Iva, Nalls, Michael A., Hernandez, Dena, Psaty, Bruce M., Rivadeneira, Fernando, Rotter, Jerome, Seshadri, Sudha, Smith, Albert V., Taylor, Kent D., Tiemeier, Henning, Uh, Hae-Won, Uitterlinden, André G., Vaupel, James W., Walston, Jeremy, Westendorp, Rudi G., Harris, Tamara B., Lumley, Thomas, van Duijn, Cornelia M., and Murabito, Joanne M.

Published
2010
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