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2,023 results on '"Wei EN"'

102. Analgesic effects of intraperitoneal lidocaine in adults undergoing surgery: a systematic review and meta-analysis with trial sequential analysis.

Author

Ng, Ka Ting, Lim, Wei En, Teoh, Wan Yi, and Abidin, Mohd Fitry Bin Zainal

Subjects
*VOMITING prevention, *MEDICAL information storage & retrieval systems, *INTRAPERITONEAL injections, *SURGERY, *PATIENTS, *MORPHINE, *POSTOPERATIVE pain, *META-analysis, *DESCRIPTIVE statistics, *SYSTEMATIC reviews, *MEDLINE, *ANALGESIA, *CONFIDENCE intervals, *LIDOCAINE, *DIET, *NAUSEA
Abstract

Objective The administration of local anesthesia in intraperitoneal space as part of the multi-modal analgesic regimen has shown to be effective in reducing postoperative pain. Recent studies demonstrated that intraperitoneal lidocaine may provide analgesic effects. Primary objective was to determine the impact of intraperitoneal lidocaine on postoperative pain scores at rest. Design We carried out a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Methods Databases of MEDLINE, EMBASE, and CENTRAL were searched from their inception date until May 2023. Randomized clinical trials (RCT) comparing intraperitoneal lidocaine and placebo in adults undergoing surgery were included. Results Our systematic review included 24 RCTs (n = 1824). The intraperitoneal lidocaine group was significantly associated with lower postoperative pain scores at rest (MD, −0.87, 95% CI, −1.04 to −0.69) and at movement (MD, −0.50, 95% CI, −0.93 to −0.08) among adult patients after surgery. Its administration also significantly decreased morphine consumption (MD, −6.42 mg, 95% CI, −11.56 to −1.27) and lowered the incidence of needing analgesia (OR, 0.22, 95% CI, 0.14 to 0.35). Intraperitoneal lidocaine statistically reduced time to resume regular diet (MD, 0.16 days; 95% CI, −0.31 to −0.01) and lowered postoperative incidence of nausea and vomiting (OR, 0.54, 95% CI, 0.39 to 0.75). Conclusions In this review, our findings should be interpreted with caution. Future studies are warranted to determine the optimal dose of administering intraperitoneal lidocaine among adult patients undergoing surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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103. The Association Between Plasma Amyloid-β 42/40 and Percentage of Semantic Intrusion Errors in Mild Cognitive Impairment.

Author

Curiel Cid, Rosie E., Ortega, Alexandra, Vaillancourt, David, Asken, Breton, Crocco, Elizabeth A., Armstrong, Melissa J., Duara, Ranjan, Crenshaw, Kirsten, Adjouadi, Malek, Rosselli, Monica, Wang, Wei-en, and Loewenstein, David A.

Subjects
AMNESTIC mild cognitive impairment, MILD cognitive impairment, ALZHEIMER'S disease, OLDER people, COGNITION disorders
Abstract

Background: Semantic intrusion errors (SIEs) are both sensitive and specific to PET amyloid-β (Aβ) burden in older adults with amnestic mild cognitive impairment (aMCI). Objective: Plasma Aβ biomarkers including the Aβ42/40 ratio using mass spectrometry are expected to become increasingly valuable in clinical settings. Plasma biomarkers are more clinically informative if linked to cognitive deficits that are salient to Alzheimer's disease (AD). Methods: This study included 119 older adults enrolled in the 1Florida Alzheimer's Disease Research Center (ADRC), 45 aMCI participants scored below the established Aβ42/40 ratio cut-off of 0.160 using the Quest AD-Detect™ assay indicating Aβ positivity (Aβ+), while 50 aMCI participants scored above this cut-off indicating Aβ negative status (Aβ–). Additionally, 24 cognitively unimpaired (CU) persons scored above the cut-off of 0.160 (Aβ–). Results: The aMCI plasma Aβ+ group evidenced the greatest percentage of SIEs, followed by the aMCI Aβ–. The CU Aβ– group exhibited the lowest percentage of SIEs. After adjustment for global cognitive impairment, aMCI plasma Aβ+ continued to demonstrate greater SIEs on tests tapping the failure to recover from proactive semantic interference (frPSI) as compared to the aMCI Aβ–group. Using pre-established cut-offs for frPSI impairment, 8.3% of CU Aβ– participants evidenced deficits, compared to 37.8% of aMCI Aβ–, and 74.0% of aMCI Aβ+. Conclusions: SIEs reflecting frPSI were associated with aMCI Aβ+ status based on the Aβ42/40 ratio. Results suggest the importance of SIEs as salient cognitive markers that map onto underlying AD pathology in the blood. [ABSTRACT FROM AUTHOR]

Published
2024
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116. Introduction

Author

Lo, Patrick, primary, Sutherland, Robert, additional, Hsu, Wei-En, additional, and Girsberger, Russ, additional

Published
2022
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