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2,999 results on '"Watson, Thomas"'

105. Lift-and-Project Integrality Gaps for the Traveling Salesperson Problem

Author

Watson, Thomas

Subjects
Computer Science - Data Structures and Algorithms
Abstract

We study the lift-and-project procedures of Lov{\'a}sz-Schrijver and Sherali-Adams applied to the standard linear programming relaxation of the traveling salesperson problem with triangle inequality. For the asymmetric TSP tour problem, Charikar, Goemans, and Karloff (FOCS 2004) proved that the integrality gap of the standard relaxation is at least 2. We prove that after one round of the Lov{\'a}sz-Schrijver or Sherali-Adams procedures, the integrality gap of the asymmetric TSP tour problem is at least 3/2, with a small caveat on which version of the standard relaxation is used. For the symmetric TSP tour problem, the integrality gap of the standard relaxation is known to be at least 4/3, and Cheung (SIOPT 2005) proved that it remains at least 4/3 after $o(n)$ rounds of the Lov{\'a}sz-Schrijver procedure, where $n$ is the number of nodes. For the symmetric TSP path problem, the integrality gap of the standard relaxation is known to be at least 3/2, and we prove that it remains at least 3/2 after $o(n)$ rounds of the Lov{\'a}sz-Schrijver procedure, by a simple reduction to Cheung's result., Comment: 19 pages, 8 figures

Published
2011

106. Huntingtin Plays a Role in the Physiological Response to Ethanol in Drosophila

Author

Clabough, Erin B.D., primary, Aspili, Christia, additional, Fussy, William S., additional, Ingersoll, James D., additional, Kislyakov, Amy, additional, Li, Elizabeth S., additional, Su, Meng-Jiuan, additional, Wiles, Dustin B., additional, Watson, Thomas E., additional, Willy, Aaron J., additional, Thomas Vinyard, H., additional, Mollica III, Philip J., additional, Taylor, James V., additional, Smith, Cody W., additional, Roark, Dallas A., additional, Tabrani, Zachary P., additional, Thomas, Harris L., additional, Shin, Mimi, additional, Venton, B. Jill, additional, Hayes, David, additional, and Sipe, Conor W., additional

Published
2023
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107. Rankin Triple Products and Quantum Chaos

Author

Watson, Thomas C.

Subjects
Mathematics - Number Theory, Mathematical Physics, Mathematics - Dynamical Systems, M11F67, 81Q50 (Primary), 11F27, 11M26, 37A45 (Secondary)
Abstract

We prove explicit Harris-Kudla type formulas for triples of Maass forms, holomorphic forms, and combinations thereof, on the hyperbolic plane modulo congruence groups and co-compact lattices arising from Eichler orders of quaternion algebras. These formulas relate the central value of the corresponding Rankin triple product L-function to a squared trilinear period integral. Assuming subconvexity estimates for these L-values, we prove Quantum Unique Ergodicity on such quotients; the relevant Lindelof hypotheses imply a quantitative form of QUE, with an optimal rate. In connection with the Berry/Hejhal Random Wave conjecture, we prove decay of third moments in the high energy limit, making use of a subconvexity result of Iwaniec/Ivic/Jutila and Kim-Shahidi's result on cuspidality of the symmetric cube., Comment: 58 pages. A reformatted version, with minor revisions, of my Ph.D. thesis (Princeton 2002, adviser: Peter Sarnak). For the original, see 0810.0425v1.

Published
2008

110. A Quantum Time-Space Lower Bound for the Counting Hierarchy

Author

van Melkebeek, Dieter and Watson, Thomas

Subjects
Quantum Physics
Abstract

We obtain the first nontrivial time-space lower bound for quantum algorithms solving problems related to satisfiability. Our bound applies to MajSAT and MajMajSAT, which are complete problems for the first and second levels of the counting hierarchy, respectively. We prove that for every real d and every positive real epsilon there exists a real c>1 such that either: MajMajSAT does not have a quantum algorithm with bounded two-sided error that runs in time n^c, or MajSAT does not have a quantum algorithm with bounded two-sided error that runs in time n^d and space n^{1-\epsilon}. In particular, MajMajSAT cannot be solved by a quantum algorithm with bounded two-sided error running in time n^{1+o(1)} and space n^{1-\epsilon} for any epsilon>0. The key technical novelty is a time- and space-efficient simulation of quantum computations with intermediate measurements by probabilistic machines with unbounded error. We also develop a model that is particularly suitable for the study of general quantum computations with simultaneous time and space bounds. However, our arguments hold for any reasonable uniform model of quantum computation., Comment: 25 pages

Published
2007

112. Rounding Out the U.S. Call for Social Corporate Purpose

Author

Seijts, Gerard and Watson, Thomas

Subjects
Corporate governance, Business schools, Stockholders, Corporate directors, Financial crises, Business, general, Business, Business, international
Abstract

Extra. Extra. Read all about it. America's top CEOs recently issued a statement that says making money for shareholders isn't the only responsibility of management. This, of course, isn't news [...]

Published
2019

113. The Real Value of Bitcoin

Author

Watson, Thomas

Subjects
Cryptocurrencies, Television comedies, Television programs, Business, general, Business, Business, international
Abstract

According to bitcoin lore, the world's first cryptocurrency transaction was made on May 22, 2010, when 10,000 BTC were exchanged for two pizzas. Bitcoin has been relatively well known in [...]

Published
2019

114. Fighting Shareholder Populism

Author

Watson, Thomas

Subjects
Institutional Shareholder Services -- Officials and employees, Johnston Press PLC -- Officials and employees, Procter & Gamble Co. -- Officials and employees, Stockholders, Populism, Chairpersons, Cleaning agents industry -- Officials and employees, Newspaper publishing -- Officials and employees, Books, Modern literature, Activists, Managers, Business, general, Business, Business, international
Abstract

On the surface, Jeff Gramm's book Dear Chairman is just a fascinating history of the investor rights movement told through activist letters dating back to the 1920s. As such, at [...]

Published
2019

115. Tweetledee Tweetledumb

Author

Watson, Thomas

Subjects
President of the United States -- Beliefs, opinions and attitudes -- Public relations, Occult fiction, Media executives, Novels, Company public relations, Business, general, Business, Business, international, Twitter (Online social network) -- Political aspects -- Usage
Abstract

The pen is mightier than the sword, at least according to Cardinal Richelieu. In the historical play by Edward Bulwer-Lytton--who is ironically also known for penning a novel using the [...]

Published
2019

116. SNC-Lavalin and the Corruption of Public Discourse

Author

Watson, Thomas

Subjects
SNC-Lavalin Group Inc. -- Investigations -- Political aspects, Corporate corruption -- Investigations -- Political aspects, Engineering services -- Investigations -- Political aspects, Prime ministers -- Ethical aspects, Managers -- Ethical aspects, Journalistic ethics, Canadians, Political parties, Party leaders, Political corruption, Journalists, Scandals, Opposition (Political science), Company legal issue, Business, general, Business, Business, international, Organisation for Economic Co-operation and Development -- Powers and duties
Abstract

Nobody loves a good government scandal more than journalists and opposition party members, except perhaps policy pundits, pollsters, and Internet trolls. And that, in a nutshell, is why the political [...]

Published
2019

127. MANAGING THE HASSLE FACTOR IN THE AGE OF DISRUPTION

Author

Schotter, Andreas, Beamish, Paul, and Watson, Thomas

Subjects
McKinsey and Company Inc. -- Management, Consulting services, Company business management, Business, general, Business, Business, international
Abstract

In a recent note on the business implications of COVID-19, McKinsey & Company advised corporate leaders to forget about trying to conduct 'business as usual' and focus instead on ensuring [...]

Published
2020

130. Utility of erector spinae plane block in thoracic surgery

Author

Pirsaharkhiz, Naghmeh, Comolli, Kelly, Fujiwara, Wakana, Stasiewicz, Susan, Boyer, Jeanne M., Begin, Eileen V., Rubinstein, Adam J., Henderson, Hayley R., Lazar, John F., Watson, Thomas J., Eger, Christopher M., Trankiem, Christine T., Phillips, Debra G., and Khaitan, Puja Gaur

Published
2020
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135. Contributors

Author

Abbas, Abbas E., primary, Adams, David B., additional, Aggarwal, Piyush, additional, Ahmed, Bestoun H., additional, Albanese, Craig, additional, Albert, Matthew R., additional, Ali, Abubaker, additional, Alicuben, Evan, additional, Allaix, Marco E., additional, Altman, Ashley, additional, Ando, Hisami, additional, Andolfi, Ciro, additional, Annamalai, Alagappan, additional, Asare, Elliot A., additional, Asti, Emanuele, additional, Auchincloss, Hugh G., additional, Babic, Benjamin, additional, Baker, Talia B., additional, Ball, Chad G., additional, Barbetta, Arianna, additional, Barlow, John M., additional, Barr, Justin, additional, Barreto, Juan Camilo, additional, Barry, Linda, additional, Beal, Eliza W., additional, Beard, Kristin Wilson, additional, Beck, David E., additional, Behrns, Kevin E., additional, Bellevue, Oliver C., additional, Bellorin-Marin, Omar E., additional, Bergman, Jacques, additional, Berry, James, additional, Besselink, Marc G.H., additional, Bharucha, Adil E., additional, Bilchik, Anton J., additional, Bildzukewicz, Nikolai A., additional, Bingham, Jason, additional, Birnbaum, Elisa, additional, Black, Sylvester M., additional, Blackmon, Shanda H., additional, Bleier, Joshua I.S., additional, Bodzin, Adam S., additional, Boland, C. Richard, additional, Bolton, John, additional, Bolton, Nathan, additional, Bonavina, Luigi, additional, Bonds, Morgan, additional, Bouwense, Stefan A.W., additional, Boys, Joshua A., additional, Bravo-Infante, Raquel, additional, Bremner, Ross M., additional, Brenner, Bruce M., additional, Brown, Shaun R., additional, Callery, Mark P., additional, Cameron, John L., additional, Camilleri, Michael, additional, Campbell, Jacob, additional, Cassim, Riaz, additional, Castillo-Angeles, Manuel, additional, Cauley, Christy, additional, Cavaness, Keith M., additional, Cerfolio, Robert J., additional, Champagne, Bradley J., additional, Chandrasoma, Parakrama, additional, Chang, Alex L., additional, Chapman, Christopher G., additional, Chapman, William C., additional, Cheek, Susannah, additional, Chen, Harvey S., additional, Cho, Clifford S., additional, Choi, Eric T., additional, Choi, Eugene A., additional, Chojnacki, Karen A., additional, Choti, Michael A., additional, Christie, Ian, additional, Chua, Heidi, additional, Church, James M., additional, Cioffi, Jessica L., additional, Clark, Susannah, additional, Clavien, Pierre-Alain, additional, Cloud, Adam, additional, Colavita, Paul D., additional, Colquhoun, Steven D., additional, Conway, William, additional, Cools-Lartigue, Jonathan, additional, Coosemans, Willy, additional, Cornwell, Edward E., additional, Costantini, Mario, additional, Coyle, Yvonne, additional, Craig, Daniel A., additional, Croome, Kristopher P., additional, Cullen, Joseph J., additional, D'Andrea, Anthony P., additional, Dassopoulos, Themistocles, additional, Davila, Marta L., additional, Davila, Raquel E., additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Dempsey, Daniel T., additional, dePrisco, Gregory, additional, Depypere, Lieven, additional, Dietz, David W., additional, Dillhoff, Mary E., additional, DiNorcia, Joseph, additional, Doane, Stephen M., additional, Dogeas, Epameinondas, additional, Dozois, Eric J., additional, Dumon, Kristoffel, additional, Dunn, Stephen P., additional, Dunst, Christy M., additional, Dussel, John N., additional, Dyer, Matthew, additional, Efron, Jonathan, additional, El-Gohary, Yousef, additional, Lakis, Mustapha El, additional, Ellison, E. Christopher, additional, Ellsmere, James, additional, Essani, Rahila, additional, Evans, Douglas B., additional, Fang, Sandy H., additional, Fasen, Geoffrey, additional, Fernando, Hiran C., additional, Ferri, Lorenzo, additional, Fichera, Alessandro, additional, Finck, Christine, additional, Fisher, Oliver M., additional, Fleshman, James W., additional, Fong, Yuman, additional, Foreman, Michael L., additional, Francone, Todd D., additional, Franko, Edward R., additional, French, Daniel, additional, Fuchs, Hans Friedrich, additional, Fuchs, Karl Hermann, additional, Funaki, Brian, additional, Funk, Geoffrey A., additional, Fusco, Joseph, additional, Gaitonde, Shrawan G., additional, Gajjar, Aakash H., additional, Garcia-Aguilar, Julio, additional, Gearhart, Susan, additional, Geller, David A., additional, Ghobadi, Comeron, additional, Gilbert, Sebastien, additional, Giles, David, additional, Gillaspie, Erin, additional, Girotti, Micah, additional, Gittes, George K., additional, Goodman, Michael D., additional, Gooszen, Hein G., additional, Gores, Gregory J., additional, Griffin, James F., additional, Griffin, S. Michael, additional, Grimm, Leander, additional, Grochola, L.F., additional, Habib, Fahim, additional, Hanks, John B., additional, Harris, James E., additional, Hartwig, Matthew G., additional, Hassan, Imran, additional, Hedrick, Traci L., additional, Hicks, Terry C., additional, Hodin, Richard, additional, Hofstetter, Wayne L., additional, Hogg, Melissa, additional, Hu, Yue-Yung, additional, Hungness, Eric S., additional, Hunt, Steven R., additional, Huseynova, Khumara, additional, Hyman, Neil H., additional, Iannitti, David A., additional, Indes, Jeffrey, additional, Jenkins, Megan, additional, Jensen, Todd, additional, Jeziorczak, Paul M., additional, Jilani, Danial, additional, Jiménez-Toscano, Marta, additional, Jobe, Blair A., additional, Johnston, Lily E., additional, Kahrilas, Peter J., additional, Kalady, Matthew F., additional, Kassira, Noor, additional, Katkhouda, Namir, additional, Katz, Philip O., additional, Keller, Deborah S., additional, Kelley, Matthew P., additional, Kennedy, Gregory D., additional, Kent, Tara Sotsky, additional, Kia, Leila, additional, Kibbe, Melina R., additional, Kim, John, additional, King, Alice, additional, Kiran, Ravi P., additional, Kirton, Orlando C., additional, Klein, Andrew, additional, Klein, Eric N., additional, Kohn, Geoffrey P., additional, Kovell, Robert Caleb, additional, Kozol, Robert, additional, Lacy, Antonio M., additional, Ladner, Daniela P., additional, Lagarde, S.M., additional, Laituri, Carrie A., additional, Landmann, Alessandra, additional, Lee, Janet T., additional, Lee, Lawrence L., additional, Leinicke, Jennifer A., additional, Lerut, Toni, additional, Levi, David M., additional, Li, Chao, additional, Liang, Yu, additional, Lichliter, Andrew H., additional, Lichliter, Warren E., additional, Lightner, Amy L., additional, Lile, Deacon J., additional, Lillemoe, Keith D., additional, Lin, Jules, additional, Lin, Shu S., additional, Lipham, John C., additional, Litle, Virginia R., additional, Lodhia, Nayna A., additional, Longo, Walter E., additional, Lord, Reginald V.N., additional, Louie, Brian E., additional, Low, Donald E., additional, Lowe, Val J., additional, Luc, Jessica G.Y., additional, Luketich, James D., additional, Ma, Yanling, additional, MacCarty, Robert L., additional, MacDonald, Blair, additional, Madoff, Robert D., additional, Magge, Deepa, additional, Maheshwari, Anurag, additional, Mahmoud, Najjia N., additional, Mahvi, David A., additional, Mahvi, David M., additional, Mak, Grace Z., additional, Mansfield, Sara A., additional, Manzano, Maricarmen, additional, Maron, David J., additional, Mathew, Melvy S., additional, Mathis, Kellie L., additional, Matthews, Jeffrey B., additional, McFadden, David W., additional, Merchea, Amit, additional, Messaris, Evangelos, additional, Miller, Daniel L., additional, Miller, Heidi J., additional, Millis, J. Michael, additional, Mittal, Sumeet K., additional, Molena, Daniela, additional, Montgomery, Stephanie C., additional, Moore, Ryan, additional, Morgan, Katherine A., additional, Mortenson, Melinda M., additional, Mulholland, Michael W., additional, Mulvihill, Michael S., additional, Mutch, Matthew, additional, Nafteux, Philippe Robert, additional, Nagaraju, Arun, additional, Nagorney, David M., additional, Nathan, Hari, additional, Natoli, Karen R., additional, Navuluri, Rakesh, additional, Nissen, Nicholas N., additional, Nobel, Tamar B., additional, Noordman, B.J., additional, Norton, Jeffrey A., additional, Novitsky, Yuri W., additional, Nussbaum, Michael S., additional, Nyberg, Scott L., additional, Oelschlager, Brant K., additional, Oh, Daniel S., additional, Otero-Piñeiro, Ana, additional, Oto, Aytekin, additional, Pachter, H. Leon, additional, Paidas, Charles N., additional, Palazzo, Francesco, additional, Paniccia, Alessandro, additional, Papaconstantinou, Harry T., additional, Pappas, Theodore N., additional, Pappou, Emmanouil P., additional, Parikh, Manish, additional, Paruch, Jennifer L., additional, Patel, Asish D., additional, Patel, Mikin, additional, Patti, Marco G., additional, Paulson, Emily Carter, additional, Pawlik, Timothy M., additional, Payne, Isaac, additional, Pemberton, John H., additional, Pendola, Michael, additional, Perez, Alexander, additional, Pernar, Luise I.M., additional, Peters, Walter R., additional, Petrowsky, Henrik, additional, Peyre, Christian G., additional, Phillips, Alexander W., additional, Pillai, Lashmikumar, additional, Plummer, Joseph M., additional, Pointer, David T., additional, Poruk, Katherine E., additional, Posner, Mitchell C., additional, Postier, Russell, additional, Prachand, Vivek N., additional, Pritts, Timothy A., additional, Quatrino, Gregory, additional, Ranka, Sagar, additional, Rattner, David W., additional, Reavis, Kevin M., additional, Reddy, Vikram B., additional, Remzi, Feza H., additional, Ricciardi, Rocco, additional, Rice, Thomas W., additional, Richman, Aaron, additional, Rider, Paul, additional, Roberts, John Paul, additional, Roberts, Patricia L., additional, Roggin, Kevin K., additional, Roll, Garrett Richard, additional, Rona, Kais, additional, Rosen, Charles B., additional, Ross, Samuel Wade, additional, Roth, J. Scott, additional, Rushing, Amy P., additional, Safar, Bashar, additional, Saldinger, Pierre F., additional, Samakar, Kamran, additional, Sandhu, Kulmeet K., additional, Schaheen, Lara W., additional, Schirmer, Bruce, additional, Schneider, Andrew, additional, Schulick, Richard D., additional, Schwab, Ben, additional, Scurci, Stephanie, additional, Senagore, Anthony, additional, Shah, Adil A., additional, Shah, Shimul A., additional, Shames, Brian, additional, Shanmugan, Skandan, additional, Shapiro, David S., additional, Silviera, Matthew, additional, Slakey, Douglas P., additional, Sloan, Joshua, additional, Smallwood, Nathan, additional, Smith, Shane P., additional, Smithers, B. Mark, additional, Smoot, Rory L., additional, Soares, Kevin C., additional, Soffer, Edy, additional, Solomina, Julia, additional, Soper, Nathaniel J., additional, Spechler, Stuart Jon, additional, Sridhar, Praveen, additional, Steele, Scott R., additional, Sternbach, Joel M., additional, Stevenson, Christina E., additional, Strong, Scott A., additional, Sucandy, Iswanto, additional, Sundaram, Magesh, additional, Sundaresan, Sudhir, additional, Swanstrom, Lee L., additional, Sylla, Patricia, additional, Takada, Tadahiro, additional, Talbot, Ethan, additional, Tam, Vernissia, additional, Tamm, Eric P., additional, Tatarian, Talar, additional, Tavakkoli, Ali, additional, Te, Helen S., additional, Teitelbaum, Ezra N., additional, Ternent, Charles A., additional, Thompson, Jon S., additional, Thomson, Iain, additional, Thorson, Alan G., additional, Thorson, Chad M., additional, Totten, Crystal F., additional, Truty, Mark J., additional, Tsai, Susan, additional, Tseng, Jennifer, additional, Tullius, Tom, additional, Tzakis, Andreas G., additional, van Lanschot, J.J.B., additional, van Santvoort, Hjalmar C., additional, Van Veer, Hans, additional, Vega, Jorge A., additional, Velanovich, Vic, additional, Vogler, Sarah A., additional, Wang, Huamin, additional, Ward, Mark A., additional, Warner, Brad W., additional, Warner, Susanne G., additional, Watson, Thomas J., additional, Waxman, Irving, additional, Webster-Lake, Carissa, additional, Wei, Benjamin, additional, Weiser, Martin R., additional, Wells, Dennis, additional, Wells, Katerina, additional, Welton, Mark Lane, additional, Wen, Yuxiang, additional, Wendling, Mark R., additional, Wesson, Hadley K.H., additional, Wexner, Steven D., additional, White, Rebekah R., additional, Whitlow, Charles B., additional, Wijnhoven, B.P.L., additional, Wilkes, Justin, additional, Wilson, Rickesha L., additional, Witkowski, Piotr, additional, Wolfgang, Christopher L., additional, Worrell, Stephanie G., additional, Yang, Jian, additional, Yeo, Charles J., additional, Yeung, Ching, additional, Yung, Evan E., additional, Zafar, Syed Nabeel, additional, Zaninotto, Giovanni, additional, Zeh, Herbert, additional, Zehetner, Joerg, additional, Zenilman, Michael E., additional, Zimmerman, Pamela, additional, and Zuccaro, Gregory, additional

Published
2019
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137. Development of pluripotent stem cells from domestic and wild suidae for the study of host pathogen interactions in vitro

Author

Watson, Thomas Milne, Burdon, Thomas, Donadeu, Francesc, and Wellcome Trust

Subjects
publicness, Operationalising ‘publicness’, health research, data-intensive health research, health research regulation, data-intensive health research regulation, regulatory device, public interest
Abstract

African Swine Fever (ASF) disease is caused by infection of susceptible Suidae with African Swine Fever Virus (ASFV). In Eurasian domestic pigs, and closely related wild boar, ASF is characterised by a haemorrhagic fever and a high mortality rate of 95-100%. There are currently no effective treatments for ASF, and as such, ASF is a major threat to pig production worldwide. An outbreak of ASF across Eurasia lead to an estimated global loss of around ¼ of all domestic pigs between 2018 and 2019. By contrast, although native African pig species such as the warthog, red river hog (RRH) and bush pigs are infected by ASFV, they carry a lower viral load and do not show clinical signs of infection. The current gold standard model for the study of ASFV in vitro are primary macrophages harvested from domestic pigs. Primary macrophages have limited proliferative potential in vitro and their use requires a constant supply from sacrificed animals. This is at odds with the 3Rs principal to reduce animal use in research. Moreover, primary macrophages are not readily amenable to genetic modification, making it difficult to interrogate gene function in this cell culture model. There is limited access to primary macrophages from wild suid species, leaving the genetic variation responsible for ASFV tolerance in wild African species largely unexplored. This project aims to produce better in vitro models to study ASFV using induced pluripotent stem cells (iPSCs). IPSCs can be expanded indefinitely in culture and can differentiate into any cell type of the three germ layers. This provides a genetically stable platform for in vitro gene editing and allows for the functional analysis of the genetic variation seen in wild Suidae, including ASFV tolerant RRHs and ASFV susceptible wild boar. This project has used tetracycline regulatable reprogramming factors to produce iPSCs from the domestic pig, RRH, and wild boar. The iPSCs were dependant on exogenous reprograming factor expression for maintenance of the undifferentiated state, but were shown to self-renew and produce derivatives of all three germ layers, including macrophages, after directed differentiation in vitro. Moreover, they were amenable to genetic modification using CRISPR/Cas9 as shown through the generation of REX1-GFP stem cell reporter lines. IPSC-derived macrophages (iPSCdM) exhibited molecular signatures of macrophage identity as determined by RT-qPCR, surface marker expression and RNA-Seq. In addition, they were able to phagocytose foreign particles and could be infected by macrophage specific pathogens including porcine reproductive and respiratory syndrome virus (PRRSV). Domestic pig iPSCdMs supported replication of ASFV to the same level as pig embryonic stem cell derived macrophages and pig ex vivo derived macrophages, making them an appropriate model for the study of ASFV in vitro. Comparison of ASFV infection between domestic pig and RRH iPSCdMs matched the in vivo infection kinetics, with lower levels of viral replication in the ASFV tolerant RRH. RNA-Seq analysis, and confirmatory RT-qPCR, indicated that infection and immunity related genes, including the pattern recognition receptors TLR2, TLR4 and inflammasome regulator CASP1, were downregulated in RRH macrophages. Corresponding differences were also noted in the iPSCdMs in response to immune stimulation. As a proof of principle, TLR2 knock-out domestic pig iPSCs were generated as a model to study the role of this pattern recognition receptor during ASFV infection in future experiments. Taken together, the results in this thesis show that iPSCdMs provide a useful new model for the study of ASFV tolerance in vitro. This also shows the potential of iPSC technology to effectively capture and interrogate biologically interesting and important genetic variation of wild animal species.

Published
2023

139. Management Theory 2.0: Made (and Innovated) in China

Author

Watson, Thomas

Subjects
Haier Group Corp. -- Officials and employees, Management techniques -- Forecasts and trends, Chief executive officers -- Interviews, Management -- Forecasts and trends, Home appliances industry -- Officials and employees, Market trend/market analysis, Business, general, Business, Business, international
Abstract

For more than a few companies, surviving the coming tidal waves of disruption will take more than a few tweaks to how business is currently done. According to Peter Weill, [...]

Published
2018

140. Young Minds Walking Tall

Author

Watson, Thomas

Subjects
Teachers -- Interviews, Robotics -- Competitions, Business, general, Business, Business, international
Abstract

There are inspiring social entrepreneurs and then there are members of the Walking Lead, a group of teenage robotics engineers from Toronto's Glen Ames Senior Public School. Indeed, while competing [...]

Published
2018

141. THE REAL VALUE OF BITCOIN

Author

Watson, Thomas

Subjects
Canada -- Economic aspects, Financial markets -- Forecasts and trends, Global economy -- Forecasts and trends, Cryptocurrencies -- Forecasts and trends -- Valuation, Market trend/market analysis, Business, general, Business, Business, international
Abstract

According to bitcoin lore, the world's first cryptocurrency transaction was made on May 22, 2010, when 10,000 BTC were exchanged for two pizzas. Bitcoin has been relatively well known in [...]

Published
2018

143. COVID-19 and Outpatient Dialysis

Author

Silberzweig, Jeffrey, primary, Wu, Sylvia, additional, Sinclair, Matthew, additional, Watson, Thomas, additional, Welder, Nancy, additional, Concepcion, Danilo, additional, Yee, Jerry, additional, Speed, Felicia, additional, Cukor, Daniel, additional, Schiller, Brigitte, additional, and Weiner, Daniel, additional

Published
2023
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144. Long-term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux

Author

Ganz, Robert A., Edmundowicz, Steven A., Taiganides, Paul A., Lipham, John C., Smith, C. Daniel, DeVault, Kenneth R., Horgan, Santiago, Jacobsen, Garth, Luketich, James D., Smith, Christopher C., Schlack-Haerer, Steven C., Kothari, Shanu N., Dunst, Christy M., Watson, Thomas J., Peters, Jeffrey, Oelschlager, Brant K., Perry, Kyle A., Melvin, Scott, Bemelman, Willem A., Smout, André J.P.M., and Dunn, Dan

Published
2016
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146. Auditors' Risk- and Materiality Assessment During Times of High Exogenous Risk : A Quantitative Study Analysing the Effects of the Covid-19 Pandemic

Author

Brissman, Adam and Watson, Thomas

Subjects
Professional Scepticism, Risk, Auditor Independence, Materiality, Materiality Assessment, Auditing, Covid-19, Risk Assessment, Economic Crises, Business Administration, Företagsekonomi
Abstract

Background: Research has shown that the risk of material misstatements increases during exogenous risk shocks. Simultaneously, auditors shall identify and assess the emergent risks. During the GFC, auditors' response was considered satisfactory by some but criticized byothers. Covid-19 presents a new exogenous risk shock which should entail a similar response by auditors. Purpose: The purpose of this study is to determine the effect that exogenous risks during uncertain economic times have on the risk- and materiality assessments of auditors. Further, to determine if auditor independence and trait scepticism affect the relationship between exogenous risk and risk- and materiality assessments. Methodology: This study used a quantitative method by sending out questionnaires to Swedish authorized and approved auditors. The answers were analysed through Spearman correlation matrixes, Paired-samples T-tests, Ordinary Least Squares (OLS) regressions and a binary logistics regression. This study is based on a positivistic perspective and a deductive approach was used. Conclusion: The findings indicated that auditors did make more conservative risk assessments in response to the Covid-19 pandemic. However, they did not adjust the materiality assessments nor performance materiality assessments significantly. Moreover, that the individually situated factors of auditors had impact on the assessments during the pandemic.

Published
2023

149. Even NAFTA Tweaks Could Be Costly

Author

Watson, Thomas

Subjects
Trade agreements, Conferences and conventions, Prime ministers, Economic conditions, Business, general, Business, Business, international
Abstract

Canadian Prime Minister Justin Trudeau did about as well as could be expected during his first face-to-face meeting with U.S. President Donald Trump, at least from a business perspective. After [...]

Published
2019

150. Trumpeting Fair Debate

Author

Watson, Thomas

Subjects
Leadership -- Economic aspects -- Political aspects, President of the United States -- Evaluation, Business, general, Business, Business, international
Abstract

Billionaire bad boy Donald Trump surprised the world by winning the U.S. Republican nomination race. He then surprised the world again by winning the White House. Shortly after, I penned [...]

Published
2019

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