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102. Capacitive sensing of test mass motion with nanometer precision over millimeter-wide sensing gaps for space-borne gravitational reference sensors

Author

Armano, M., Audley, H., Auger, G., Baird, J., Bassan, M., Binetruy, P., Born, M., Bortoluzzi, D., Brandt, N., Caleno, M., Cavalleri, A., Cesarini, A., Cruise, A. M., Danzmann, K., de Deus Silva, M., De Rosa, R., Di Fiore, L., Diepholz, I., Dixon, G., Dolesi, R., Dunbar, N., Ferraioli, L., Ferroni, V., Fitzsimons, E. D., Flatscher, R., Freschi, M., García Marirrodriga, C., Gerndt, R., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., GRADO, ANIELLO, Grimani, C., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspé, H., Jennrich, O., Jetzer, P., Johlander, B., Karnesis, N., Kaune, B., Korsakova, N., Killow, C. J., Lobo, J. A., Lloro, I., Liu, L., López-Zaragoza, J. P., Maarschalkerweerd, R., Mance, D., Martín, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., Madden, S., Mateos, I., McNamara, P. W., Mendes, J., Mendes, L., Meshksar, N., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Prat, P., Ragnit, U., Ramos-Castro, J., Reiche, J., Robertson, D. I., Rozemeijer, H., Rivas, F., Russano, G., Sarra, P., Schleicher, A., Slutsky, J., Sopuerta, C. F., Stanga, R., Sumner, T. J., Texier, D., Thorpe, J. I., Trenkel, C., Tröbs, M., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Wass, P. J., Wealthy, D., Weber, W. J., Wissel, L., Wittchen, A., Zambotti, A., Zanoni, C., Ziegler, T., Zweifel, P., LISA Pathfinder Collaboration, Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), LISA Pathfinder, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Armano, M., Audley, H., Auger, G., Baird, J., Bassan, M., Binetruy, P., Born, M., Bortoluzzi, D., Brandt, N., Caleno, M., Cavalleri, A., Cesarini, A., Cruise, A. M., Danzmann, K., De Deus Silva, M., De Rosa, R., Di Fiore, L., Diepholz, I., Dixon, G., Dolesi, R., Dunbar, N., Ferraioli, L., Ferroni, V., Fitzsimons, E. D., Flatscher, R., Freschi, M., Garcia Marirrodriga, C., Gerndt, R., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grado, A., Grimani, C., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspe, H., Jennrich, O., Jetzer, P., Johlander, B., Karnesis, N., Kaune, B., Korsakova, N., Killow, C. J., Lobo, J. A., Lloro, I., Liu, L., Lopez-Zaragoza, J. P., Maarschalkerweerd, R., Mance, D., Martin, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., Madden, S., Mateos, I., Mcnamara, P. W., Mendes, J., Mendes, L., Meshksar, N., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Prat, P., Ragnit, U., Ramos-Castro, J., Reiche, J., Robertson, D. I., Rozemeijer, H., Rivas, F., Russano, G., Sarra, P., Schleicher, A., Slutsky, J., Sopuerta, C. F., Stanga, R., Sumner, T. J., Texier, D., Thorpe, J. I., Trenkel, C., Trobs, M., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Wass, P. J., Wealthy, D., Weber, W. J., Wissel, L., Wittchen, A., Zambotti, A., Zanoni, C., Ziegler, T., and Zweifel, P.

Subjects
noise, detector: performance, Capacitive sensing, gap, Astronomy & Astrophysics, gravitational radiation: direct detection, 01 natural sciences, Noise (electronics), rotation, Displacement (vector), Physics, Particles & Fields, Gravitational waves, Optics, Ones gravitacionals, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, MISSION, Physics, LISA, Science & Technology, Spacecraft, 010308 nuclear & particles physics, business.industry, Gravitational wave, Settore FIS/01 - Fisica Sperimentale, gravitational radiation, Ranging, gravitational radiation detector, FOURIER-TRANSFORM, observatory, Pathfinder, gravitation, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], Physical Sciences, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Millimeter, business
Abstract

We report on the performance of the capacitive gap-sensing system of the Gravitational Reference Sensor on board the LISA Pathfinder spacecraft. From in-flight measurements, the system has demonstrated a performance, down to 1 mHz, that is ranging between 0.7 and \ud 1.8\ud \ud \ud aF\ud \ud Hz\ud −\ud 1\ud /\ud 2\ud . That translates into a sensing noise of the test mass motion within 1.2 and \ud 2.4\ud \ud nm\ud \ud Hz\ud −\ud 1\ud /\ud 2\ud in displacement and within 83 and \ud 170\ud \ud nrad\ud \ud Hz\ud −\ud 1\ud /\ud 2\ud in rotation. This matches the performance goals for LISA Pathfinder, and it allows the successful implementation of the gravitational waves observatory LISA. A \ud 1\ud /\ud f\ud tail has been observed for frequencies below 1 mHz, the tail has been investigated in detail with dedicated in-flight measurements, and a model is presented in the paper. A projection of such noise to frequencies below 0.1 mHz shows that an improvement of performance at those frequencies is desirable for the next generation of gravitational reference sensors for space-borne gravitational waves observation.

Published
2017

104. Patient-Specific Three-Dimensional Composite Bone Models for Teaching and Operation Planning

Author

Matthews, F, Messmer, P, Raikov, V, Wanner, G A, Jacob, A L, Regazzoni, P, Egli, A, University of Zurich, and Matthews, F

Subjects
10022 Division of Surgical Research, 1706 Computer Science Applications, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, 3614 Radiological and Ultrasound Technology
Abstract

Background: Orthopedic trauma care relies on two-dimensional radiograms both before and during the operation. Understanding the three-dimensional nature of complex fractures on plain radiograms is challenging. Modern fluoroscopes can acquire three-dimensional volume datasets even during an operation, but the device limitations constrain the acquired volume to a cube of only 12-cm edge. However, viewing the surrounding intact structures is important to comprehend the fracture in its context. We suggest merging a fluoroscope's volume scan into a generic bone model to form a composite full-length 3D bone model. Methods: Materials consisted of one cadaver bone and 20 three-dimensional surface models of human femora. Radiograms and computed tomography scans were taken before and after applying a controlled fracture to the bone. A 3D scan of the fracture was acquired using a mobile fluoroscope (Siemens Siremobil). The fracture was fitted into the generic bone models by rigid registration using a modified least-squares algorithm. Registration precision was determined and a clinical appraisal of the composite models obtained. Results: Twenty composite bone models were generated. Average registration precision was 2.0mm (range 1.6 to 2.6). Average processing time on a laptop computer was 35s (range 20 to 55). Comparing synthesized radiograms with the actual radiograms of the fractured bone yielded clinically satisfactory results. Conclusion: A three-dimensional full-length representation of a fractured bone can reliably be synthesized from a short scan of the patient's fracture and a generic bone model. This patient-specific model can subsequently be used for teaching, surgical operation planning, and intraoperative visualization purposes

Published
2018

106. LISA Pathfinder Performance Confirmed in an Open-Loop Configuration: Results from the Free-Fall Actuation Mode

Author

Armano, M., primary, Audley, H., additional, Baird, J., additional, Binetruy, P., additional, Born, M., additional, Bortoluzzi, D., additional, Castelli, E., additional, Cavalleri, A., additional, Cesarini, A., additional, Cruise, A. M., additional, Danzmann, K., additional, de Deus Silva, M., additional, Diepholz, I., additional, Dixon, G., additional, Dolesi, R., additional, Ferraioli, L., additional, Ferroni, V., additional, Fitzsimons, E. D., additional, Freschi, M., additional, Gesa, L., additional, Gibert, F., additional, Giardini, D., additional, Giusteri, R., additional, Grimani, C., additional, Grzymisch, J., additional, Harrison, I., additional, Hartig, M-S., additional, Heinzel, G., additional, Hewitson, M., additional, Hollington, D., additional, Hoyland, D., additional, Hueller, M., additional, Inchauspé, H., additional, Jennrich, O., additional, Jetzer, P., additional, Karnesis, N., additional, Kaune, B., additional, Korsakova, N., additional, Killow, C. J., additional, Lobo, J. A., additional, Liu, L., additional, López-Zaragoza, J. P., additional, Maarschalkerweerd, R., additional, Mance, D., additional, Meshksar, N., additional, Martín, V., additional, Martin-Polo, L., additional, Martino, J., additional, Martin-Porqueras, F., additional, Mateos, I., additional, McNamara, P. W., additional, Mendes, J., additional, Mendes, L., additional, Nofrarias, M., additional, Paczkowski, S., additional, Perreur-Lloyd, M., additional, Petiteau, A., additional, Pivato, P., additional, Plagnol, E., additional, Ramos-Castro, J., additional, Reiche, J., additional, Robertson, D. I., additional, Rivas, F., additional, Russano, G., additional, Slutsky, J., additional, Sopuerta, C. F., additional, Sumner, T., additional, Texier, D., additional, Thorpe, J. I., additional, Vetrugno, D., additional, Vitale, S., additional, Wanner, G., additional, Ward, H., additional, Wass, P. J., additional, Weber, W. J., additional, Wissel, L., additional, Wittchen, A., additional, and Zweifel, P., additional

Published
2019
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107. Temperature stability in the sub-milliHertz band with LISA Pathfinder

Author

Armano, M, primary, Audley, H, primary, Baird, J, primary, Binetruy, P, primary, Born, M, primary, Bortoluzzi, D, primary, Castelli, E, primary, Cavalleri, A, primary, Cesarini, A, primary, Cruise, A M, primary, Danzmann, K, primary, Silva, M de Deus, primary, Diepholz, I, primary, Dixon, G, primary, Dolesi, R, primary, Ferraioli, L, primary, Ferroni, V, primary, Fitzsimons, E D, primary, Freschi, M, primary, Gesa, L, primary, Gibert, F, primary, Giardini, D, primary, Giusteri, R, primary, Grimani, C, primary, Grzymisch, J, primary, Harrison, I, primary, Heinzel, G, primary, Hewitson, M, primary, Hollington, D, primary, Hoyland, D, primary, Hueller, M, primary, Inchauspé, H, primary, Jennrich, O, primary, Jetzer, P, primary, Karnesis, N, primary, Kaune, B, primary, Korsakova, N, primary, Killow, C J, primary, Lobo, J A, primary, Lloro, I, primary, Liu, L, primary, López-Zaragoza, J P, primary, Maarschalkerweerd, R, primary, Mance, D, primary, Mansanet, C, primary, Martín, V, primary, Martin-Polo, L, primary, Martino, J, primary, Martin-Porqueras, F, primary, Mateos, I, primary, McNamara, P W, primary, Mendes, J, primary, Mendes, L, primary, Meshksar, N, primary, Nofrarias, M, primary, Paczkowski, S, primary, Perreur-Lloyd, M, primary, Petiteau, A, primary, Pivato, P, primary, Plagnol, E, primary, Ramos-Castro, J, primary, Reiche, J, primary, Robertson, D I, primary, Rivas, F, primary, Russano, G, primary, Sanjuán, J, primary, Slutsky, J, primary, Sopuerta, C F, primary, Sumner, T, primary, Texier, D, primary, Thorpe, J I, primary, Trenkel, C, primary, Vetrugno, D, primary, Vitale, S, primary, Wanner, G, primary, Ward, H, primary, Wass, P J, primary, Wealthy, D, primary, Weber, W J, primary, Wissel, L, primary, Wittchen, A, primary, and Zweifel, P, primary

Published
2019
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108. Forbush Decreases and <2 Day GCR Flux Non-recurrent Variations Studied with LISA Pathfinder

Author

Armano, M., primary, Audley, H., additional, Baird, J., additional, Benella, S., additional, Binetruy, P., additional, Born, M., additional, Bortoluzzi, D., additional, Castelli, E., additional, Cavalleri, A., additional, Cesarini, A., additional, Cruise, A. M., additional, Danzmann, K., additional, Silva, M. de Deus, additional, Diepholz, I., additional, Dixon, G., additional, Dolesi, R., additional, Fabi, M., additional, Ferraioli, L., additional, Ferroni, V., additional, Finetti, N., additional, Fitzsimons, E. D., additional, Freschi, M., additional, Gesa, L., additional, Gibert, F., additional, Giardini, D., additional, Giusteri, R., additional, Grimani, C., additional, Grzymisch, J., additional, Harrison, I., additional, Heinzel, G., additional, Hewitson, M., additional, Hollington, D., additional, Hoyland, D., additional, Hueller, M., additional, Inchauspé, H., additional, Jennrich, O., additional, Jetzer, P., additional, Karnesis, N., additional, Kaune, B., additional, Korsakova, N., additional, Killow, C. J., additional, Kudela, K., additional, Laurenza, M., additional, Lobo, J. A., additional, Lloro, I., additional, Liu, L., additional, López-Zaragoza, J. P., additional, Maarschalkerweerd, R., additional, Mance, D., additional, Meshksar, N., additional, Martín, V., additional, Martin-Polo, L., additional, Martino, J., additional, Martin-Porqueras, F., additional, Mateos, I., additional, McNamara, P. W., additional, Mendes, J., additional, Mendes, L., additional, Nofrarias, M., additional, Paczkowski, S., additional, Perreur-Lloyd, M., additional, Petiteau, A., additional, Pivato, P., additional, Plagnol, E., additional, Ramos-Castro, J., additional, Reiche, J., additional, Robertson, D. I., additional, Rivas, F., additional, Russano, G., additional, Slutsky, J., additional, Sopuerta, C. F., additional, Sumner, T., additional, Telloni, D., additional, Texier, D., additional, Thorpe, J. I., additional, Vetrugno, D., additional, Villani, M., additional, Vitale, S., additional, Wanner, G., additional, Ward, H., additional, Wass, P., additional, Weber, W. J., additional, Wissel, L., additional, Wittchen, A., additional, and Zweifel, P., additional

Published
2019
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110. Beyond the Required LISA Free-Fall Performance: New LISA Pathfinder Results down to 20 mu Hz

Author

Armano, M., Audley, H., Baird, J., Binetruy, P., Born, M., Bortoluzzi, D., Castelli, E., Cavalleri, A., Cesarini, A., Cruise, A. M., Danzmann, K., de Deus Silva, M., Diepholz, I., Dixon, G., Dolesi, R., Ferraioli, L., Ferroni, V., Fitzsimons, E. D., Freschi, M., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grimani, C., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspe, H., Jennrich, O., Jetzer, P., Karnesis, N., Kaune, B., Korsakova, N., Killow, C. J., Lobo, J. A., Lloro, I., Liu, L., Lopez-Zaragoza, J. P., Maarschalkerweerd, R., Mance, D., Meshksar, N., Martin, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., Mateos, I., McNamara, P. W., Mendes, J., Mendes, L., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Ramos-Castro, J., Reiche, J., Robertson, D. I., Rivas, F., Russano, G., Slutsky, J., Sopuerta, C. F., Sumner, T., Texier, D., Thorpe, J. I., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Wass, P. J., Weber, W. J., Wissel, L., Wittchen, A., Zweifel, P., Armano, M., Audley, H., Baird, J., Binetruy, P., Born, M., Bortoluzzi, D., Castelli, E., Cavalleri, A., Cesarini, A., Cruise, A. M., Danzmann, K., de Deus Silva, M., Diepholz, I., Dixon, G., Dolesi, R., Ferraioli, L., Ferroni, V., Fitzsimons, E. D., Freschi, M., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grimani, C., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspe, H., Jennrich, O., Jetzer, P., Karnesis, N., Kaune, B., Korsakova, N., Killow, C. J., Lobo, J. A., Lloro, I., Liu, L., Lopez-Zaragoza, J. P., Maarschalkerweerd, R., Mance, D., Meshksar, N., Martin, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., Mateos, I., McNamara, P. W., Mendes, J., Mendes, L., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Ramos-Castro, J., Reiche, J., Robertson, D. I., Rivas, F., Russano, G., Slutsky, J., Sopuerta, C. F., Sumner, T., Texier, D., Thorpe, J. I., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Wass, P. J., Weber, W. J., Wissel, L., Wittchen, A., and Zweifel, P.

Abstract

In the months since the publication of the first results, the noise performance of LISA Pathfinder has improved because of reduced Brownian noise due to the continued decrease in pressure around the test masses, from a better correction of noninertial effects, and from a better calibration of the electrostatic force actuation. In addition, the availability of numerous long noise measurement runs, during which no perturbation is purposely applied to the test masses, has allowed the measurement of noise with good statistics down to 20 mu Hz. The Letter presents the measured differential acceleration noise figure, which is at (1.74 +/- 0.01) fm s(-2)/root Hz above 2 mHz and (6 +/- 1) x 10 fm s(-2)/root Hz at 20 mu Hz, and discusses the physical sources for the measured noise. This performance provides an experimental benchmark demonstrating the ability to realize the low-frequency science potential of the LISA mission, recently selected by the European Space Agency.

Published
2018

111. Low molecular weight heparin-induced skin necrosis—a systematic review

Author

Handschin, A., Trentz, O., Kock, H., Wanner, G., Handschin, A., Trentz, O., Kock, H., and Wanner, G.

Abstract

Background: Low molecular weight heparins (LMWHs) are currently used as a standard for anti-thrombotic therapy. Skin necrosis caused by LMWH is a rare and probably under-reported complication. The aim of our systematic review is to analyse the present literature for cases of LMWH-induced skin necrosis, emphasising the pathogenesis, clinical pattern, and management of this rare side effect. Methods: We performed a Medline literature search (PubMed database) and manual cross-referencing to identify all articles related to LMWH-induced skin necrosis. Data were analysed for type of LMWH used, time until skin necrosis occurred, localisation, size, laboratory findings, switch anticoagulant, complications, and outcome. Additionally, the case of a patient from our hospital is presented. Results: We included a total of 20 articles (21 cases) reporting on LMWH-induced skin necrosis. Skin necrosis occurred locally and distant from the injection site. Heparin-induced antibodies were frequently observed (positive 9/11 articles, negative 2/11). However, severe thrombocytopenia (platelet count <100,000cells/ml) occurred in only four cases, while platelet count remained normal in 50% of the cases. After patients had been switched to other anti-thrombotic drugs, the clinical course was usually benign; however, reconstructive surgery was necessary in two cases. Conclusion: LMWH-induced skin necrosis may occur as part of the heparin-induced thrombocytopenia (HIT) syndrome, but other pathomechanisms, including allergic reactions and local trauma, may also be involved. When HIT is excluded, unfractionated heparin is a safe switch anticoagulant. Otherwise, non-heparin preparations such as hirudin or fondaparinux should be preferred

Published
2018

112. Dahlquist's classical papers on stability theory

Author

Wanner, G. and Wanner, G.

Abstract

This text, which is based on the author's talk in honour of G. Dahlquist at the SciCade05 meeting in Nagoya, describes the two classical papers from 1956 and 1963 of Dahlquist and their enormous impact on the research of decades to come; it also allows the author to present a personal testimony of his never ending admiration for the scientific and personal qualities of this great man

Published
2018

113. Change of transfusion and treatment paradigm in major trauma patients

Author

Stein, P, Kaserer, A, Sprengel, K, Wanner, G A, Seifert, Burkhardt, Theusinger, O M, Spahn, D R, University of Zurich, and Spahn, D R

Subjects
10021 Department of Trauma Surgery, 10216 Institute of Anesthesiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2703 Anesthesiology and Pain Medicine
Published
2017

114. Laser Interferometer Space Antenna

Author

Amaro-Seoane, P, Audley, H, Babak, S, Baker, J, Barausse, E, Bender, P, Berti, E, Binetruy, P, Born, M, Bortoluzzi, D, Camp, J, Caprini, C, Cardoso, V, Colpi, M, Conklin, J, Cornish, N, Cutler, C, Danzmann, K, Dolesi, R, Ferraioli, L, Ferroni, V, Fitzsimons, E, Gair, J, Bote, LG, Giardini, D, Gibert, F, Grimani, C, Halloin, H, Heinzel, G, Hertog, T, Hewitson, M, Holley-Bockelmann, K, Hollington, D, Hueller, M, Inchauspe, H, Jetzer, P, Karnesis, N, Killow, C, Klein, A, Klipstein, B, Korsakova, N, Larson, SL, Livas, J, Lloro, I, Man, N, Mance, D, Martino, J, Mateos, I, McKenzie, K, McWilliams, ST, Miller, C, Mueller, G, Nardini, G, Nelemans, G, Nofrarias, M, Petiteau, A, Pivato, P, Plagnol, E, Porter, E, Reiche, J, Robertson, D, Robertson, N, Rossi, E, Russano, G, Schutz, B, Sesana, A, Shoemaker, D, Slutsky, J, Sopuerta, CF, Sumner, T, Tamanini, N, Thorpe, I, Troebs, M, Vallisneri, M, Vecchio, A, Vetrugno, D, Vitale, S, Volonteri, M, Wanner, G, Ward, H, Wass, P, Weber, W, Ziemer, J, and Zweifel, P

Subjects
General Relativity and Quantum Cosmology, Physics::Space Physics, Astrophysics::Instrumentation and Methods for Astrophysics, astro-ph.IM
Abstract

Following the selection of The Gravitational Universe by ESA, and the successful flight of LISA Pathfinder, the LISA Consortium now proposes a 4 year mission in response to ESA's call for missions for L3. The observatory will be based on three arms with six active laser links, between three identical spacecraft in a triangular formation separated by 2.5 million km. LISA is an all-sky monitor and will offer a wide view of a dynamic cosmos using Gravitational Waves as new and unique messengers to unveil The Gravitational Universe. It provides the closest ever view of the infant Universe at TeV energy scales, has known sources in the form of verification binaries in the Milky Way, and can probe the entire Universe, from its smallest scales near the horizons of black holes, all the way to cosmological scales. The LISA mission will scan the entire sky as it follows behind the Earth in its orbit, obtaining both polarisations of the Gravitational Waves simultaneously, and will measure source parameters with astrophysically relevant sensitivity in a band from below $10^{-4}\,$Hz to above $10^{-1}\,$Hz.

Published
2017

115. LISA Pathfinder: First steps to observing gravitational waves from space

Author

LISA Pathfinder Collaboration, Audley, H., Born, M., Danzmann, K., Diepholz, I., Heinzel, G., Hewitson, M., Karnesis, N., Kaune, B., Korsakova, N., Paczkowsk, S., Reiche, J., Troebs, M., Wanner, G., Wissel, L., and Wittchen, A.

Subjects
ddc:530, gravitational wave detection, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, ESA, Gravitational waves
Abstract

LISA Pathfinder, the European Space Agency's technology demonstrator mission for future spaceborne gravitational wave observatories, was launched on 3 December 2015, from the European space port of Kourou, French Guiana. After a short duration transfer to the final science orbit, the mission has been gathering science data since. This data has allowed the science community to validate the critical technologies and measurement principle for low frequency gravitational wave detection and thereby confirming the readiness to start the next generation gravitational wave observatories, such as LISA. This paper will briefly describe the mission, followed by a description of the science operations highlighting the performance achieved. Details of the various experiments performed during the nominal science operations phase can be found in accompanying papers in this volume.

Published
2017

116. LISA Pathfinder closed-loop analysis: a model breakdown of the in-loop observables

Author

LISA Pathfinder Collaboration, Audley, H., Born, M., Danzmann, K., Diepholz, I., Heinzel, G., Hewitson, M., Karnesis, N., Kaune, B., Korsakova, N., Paczkowski, S., Reiche, J., Troebs, M., Wanner, G., Wissel, L., and Wittchen, A.

Subjects
analysis, ddc:530, gravitational wave detection, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, LISA Pathfinder
Abstract

This paper describes a methodology to analyze, in the frequency domain, the steady-state control performances of the LISA Pathfinder mission. In particular, it provides a technical framework to give a comprehensive understanding of the spectra of all the degrees of freedom by breaking them down into their various physical origins, hence bringing out the major contributions of the control residuals. A reconstruction of the measured in-loop output, extracted from a model of the closed-loop system, is shown as an instance to illustrate the potential of such a model breakdown of the data.

Published
2017
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117. Experimental results from the ST7 mission on LISA Pathfinder

Author

Anderson, G., primary, Anderson, J., additional, Anderson, M., additional, Aveni, G., additional, Bame, D., additional, Barela, P., additional, Blackman, K., additional, Carmain, A., additional, Chen, L., additional, Cherng, M., additional, Clark, S., additional, Connally, M., additional, Connolly, W., additional, Conroy, D., additional, Cooper, M., additional, Cutler, C., additional, D’Agostino, J., additional, Demmons, N., additional, Dorantes, E., additional, Dunn, C., additional, Duran, M., additional, Ehrbar, E., additional, Evans, J., additional, Fernandez, J., additional, Franklin, G., additional, Girard, M., additional, Gorelik, J., additional, Hruby, V., additional, Hsu, O., additional, Jackson, D., additional, Javidnia, S., additional, Kern, D., additional, Knopp, M., additional, Kolasinski, R., additional, Kuo, C., additional, Le, T., additional, Li, I., additional, Liepack, O., additional, Littlefield, A., additional, Maghami, P., additional, Malik, S., additional, Markley, L., additional, Martin, R., additional, Marrese-Reading, C., additional, Mehta, J., additional, Mennela, J., additional, Miller, D., additional, Nguyen, D., additional, O’Donnell, J., additional, Parikh, R., additional, Plett, G., additional, Ramsey, T., additional, Randolph, T., additional, Rhodes, S., additional, Romero-Wolf, A., additional, Roy, T., additional, Ruiz, A., additional, Shaw, H., additional, Slutsky, J., additional, Spence, D., additional, Stocky, J., additional, Tallon, J., additional, Thorpe, I., additional, Tolman, W., additional, Umfress, H., additional, Valencia, R., additional, Valerio, C., additional, Warner, W., additional, Wellman, J., additional, Willis, P., additional, Ziemer, J., additional, Zwahlen, J., additional, Armano, M., additional, Audley, H., additional, Baird, J., additional, Binetruy, P., additional, Born, M., additional, Bortoluzzi, D., additional, Castelli, E., additional, Cavalleri, A., additional, Cesarini, A., additional, Cruise, A. M., additional, Danzmann, K., additional, de Deus Silva, M., additional, Diepholz, I., additional, Dixon, G., additional, Dolesi, R., additional, Ferraioli, L., additional, Ferroni, V., additional, Fitzsimons, E. D., additional, Freschi, M., additional, Gesa, L., additional, Gibert, F., additional, Giardini, D., additional, Giusteri, R., additional, Grimani, C., additional, Grzymisch, J., additional, Harrison, I., additional, Heinzel, G., additional, Hewitson, M., additional, Hollington, D., additional, Hoyland, D., additional, Hueller, M., additional, Inchauspé, H., additional, Jennrich, O., additional, Jetzer, P., additional, Karnesis, N., additional, Kaune, B., additional, Korsakova, N., additional, Killow, C. J., additional, Lobo, J. A., additional, Lloro, I., additional, Liu, L., additional, López-Zaragoza, J. P., additional, Maarschalkerweerd, R., additional, Mance, D., additional, Meshksar, N., additional, Martín, V., additional, Martin-Polo, L., additional, Martino, J., additional, Martin-Porqueras, F., additional, Mateos, I., additional, McNamara, P. W., additional, Mendes, J., additional, Mendes, L., additional, Nofrarias, M., additional, Paczkowski, S., additional, Perreur-Lloyd, M., additional, Petiteau, A., additional, Pivato, P., additional, Plagnol, E., additional, Ramos-Castro, J., additional, Reiche, J., additional, Robertson, D. I., additional, Rivas, F., additional, Russano, G., additional, Sopuerta, C. F., additional, Sumner, T., additional, Texier, D., additional, Vetrugno, D., additional, Vitale, S., additional, Wanner, G., additional, Ward, H., additional, Wass, P. J., additional, Weber, W. J., additional, Wissel, L., additional, Wittchen, A., additional, and Zweifel, P., additional

Published
2018
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118. Calibrating the system dynamics of LISA Pathfinder

Author

Armano, M., primary, Audley, H., additional, Baird, J., additional, Binetruy, P., additional, Born, M., additional, Bortoluzzi, D., additional, Castelli, E., additional, Cavalleri, A., additional, Cesarini, A., additional, Cruise, A. M., additional, Danzmann, K., additional, de Deus Silva, M., additional, Diepholz, I., additional, Dixon, G., additional, Dolesi, R., additional, Ferraioli, L., additional, Ferroni, V., additional, Fitzsimons, E. D., additional, Freschi, M., additional, Gesa, L., additional, Gibert, F., additional, Giardini, D., additional, Giusteri, R., additional, Grimani, C., additional, Grzymisch, J., additional, Harrison, I., additional, Heinzel, G., additional, Hewitson, M., additional, Hollington, D., additional, Hoyland, D., additional, Hueller, M., additional, Inchauspé, H., additional, Jennrich, O., additional, Jetzer, P., additional, Karnesis, N., additional, Kaune, B., additional, Korsakova, N., additional, Killow, C. J., additional, Lobo, J. A., additional, Lloro, I., additional, Liu, L., additional, López-Zaragoza, J. P., additional, Maarschalkerweerd, R., additional, Mance, D., additional, Meshksar, N., additional, Martín, V., additional, Martin-Polo, L., additional, Martino, J., additional, Martin-Porqueras, F., additional, Mateos, I., additional, McNamara, P. W., additional, Mendes, J., additional, Mendes, L., additional, Nofrarias, M., additional, Paczkowski, S., additional, Perreur-Lloyd, M., additional, Petiteau, A., additional, Pivato, P., additional, Plagnol, E., additional, Ramos-Castro, J., additional, Reiche, J., additional, Robertson, D. I., additional, Rivas, F., additional, Russano, G., additional, Slutsky, J., additional, Sopuerta, C. F., additional, Sumner, T., additional, Texier, D., additional, Thorpe, J. I., additional, Vetrugno, D., additional, Vitale, S., additional, Wanner, G., additional, Ward, H., additional, Wass, P., additional, Weber, W. J., additional, Wissel, L., additional, Wittchen, A., additional, and Zweifel, P., additional

Published
2018
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119. Reducing tilt-to-length coupling for the LISA test mass interferometer

Author

Tröbs, M, primary, Schuster, S, additional, Lieser, M, additional, Zwetz, M, additional, Chwalla, M, additional, Danzmann, K, additional, Barránco, G Fernández, additional, Fitzsimons, E D, additional, Gerberding, O, additional, Heinzel, G, additional, Killow, C J, additional, Perreur-Lloyd, M, additional, Robertson, D I, additional, Schwarze, T S, additional, Wanner, G, additional, and Ward, H, additional

Published
2018
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120. Characteristics and Energy Dependence of Recurrent Galactic Cosmic-Ray Flux Depressions and of a Forbush Decrease with LISA Pathfinder

Author

Armano, M., primary, Audley, H., additional, Baird, J., additional, Bassan, M., additional, Benella, S., additional, Binetruy, P., additional, Born, M., additional, Bortoluzzi, D., additional, Cavalleri, A., additional, Cesarini, A., additional, Cruise, A. M., additional, Danzmann, K., additional, Silva, M. de Deus, additional, Diepholz, I., additional, Dixon, G., additional, Dolesi, R., additional, Fabi, M., additional, Ferraioli, L., additional, Ferroni, V., additional, Finetti, N., additional, Fitzsimons, E. D., additional, Freschi, M., additional, Gesa, L., additional, Gibert, F., additional, Giardini, D., additional, Giusteri, R., additional, Grimani, C., additional, Grzymisch, J., additional, Harrison, I., additional, Heinzel, G., additional, Hewitson, M., additional, Hollington, D., additional, Hoyland, D., additional, Hueller, M., additional, Inchauspé, H., additional, Jennrich, O., additional, Jetzer, P., additional, Karnesis, N., additional, Kaune, B., additional, Korsakova, N., additional, Killow, C. J., additional, Laurenza, M., additional, Lobo, J. A., additional, Lloro, I., additional, Liu, L., additional, López-Zaragoza, J. P., additional, Maarschalkerweerd, R., additional, Mance, D., additional, Martín, V., additional, Martin-Polo, L., additional, Martino, J., additional, Martin-Porqueras, F., additional, Mateos, I., additional, McNamara, P. W., additional, Mendes, J., additional, Mendes, L., additional, Nofrarias, M., additional, Paczkowski, S., additional, Perreur-Lloyd, M., additional, Petiteau, A., additional, Pivato, P., additional, Plagnol, E., additional, Ramos-Castro, J., additional, Reiche, J., additional, Robertson, D. I., additional, Rivas, F., additional, Russano, G., additional, Sabbatini, F., additional, Slutsky, J., additional, Sopuerta, C. F., additional, Sumner, T., additional, Telloni, D., additional, Texier, D., additional, Thorpe, J. I., additional, Vetrugno, D., additional, Vitale, S., additional, Wanner, G., additional, Ward, H., additional, Wass, P., additional, Weber, W. J., additional, Wissel, L., additional, Wittchen, A., additional, Zambotti, A., additional, Zanoni, C., additional, and Zweifel, P., additional

Published
2018
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121. Beyond the Required LISA Free-Fall Performance: New LISA Pathfinder Results down to 20μHz

Author

Armano, M., primary, Audley, H., additional, Baird, J., additional, Binetruy, P., additional, Born, M., additional, Bortoluzzi, D., additional, Castelli, E., additional, Cavalleri, A., additional, Cesarini, A., additional, Cruise, A. M., additional, Danzmann, K., additional, de Deus Silva, M., additional, Diepholz, I., additional, Dixon, G., additional, Dolesi, R., additional, Ferraioli, L., additional, Ferroni, V., additional, Fitzsimons, E. D., additional, Freschi, M., additional, Gesa, L., additional, Gibert, F., additional, Giardini, D., additional, Giusteri, R., additional, Grimani, C., additional, Grzymisch, J., additional, Harrison, I., additional, Heinzel, G., additional, Hewitson, M., additional, Hollington, D., additional, Hoyland, D., additional, Hueller, M., additional, Inchauspé, H., additional, Jennrich, O., additional, Jetzer, P., additional, Karnesis, N., additional, Kaune, B., additional, Korsakova, N., additional, Killow, C. J., additional, Lobo, J. A., additional, Lloro, I., additional, Liu, L., additional, López-Zaragoza, J. P., additional, Maarschalkerweerd, R., additional, Mance, D., additional, Meshksar, N., additional, Martín, V., additional, Martin-Polo, L., additional, Martino, J., additional, Martin-Porqueras, F., additional, Mateos, I., additional, McNamara, P. W., additional, Mendes, J., additional, Mendes, L., additional, Nofrarias, M., additional, Paczkowski, S., additional, Perreur-Lloyd, M., additional, Petiteau, A., additional, Pivato, P., additional, Plagnol, E., additional, Ramos-Castro, J., additional, Reiche, J., additional, Robertson, D. I., additional, Rivas, F., additional, Russano, G., additional, Slutsky, J., additional, Sopuerta, C. F., additional, Sumner, T., additional, Texier, D., additional, Thorpe, J. I., additional, Vetrugno, D., additional, Vitale, S., additional, Wanner, G., additional, Ward, H., additional, Wass, P. J., additional, Weber, W. J., additional, Wissel, L., additional, Wittchen, A., additional, and Zweifel, P., additional

Published
2018
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123. Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina

Author

Eberhart, A., Feodorova, Y., Song, C., Wanner, G., Kiseleva, E., Furukawa, T., Kimura, Hiroshi, Schotta, G., Leonhardt, H., Joffe, B., and Solovei, I.

Subjects
DNA (Cytosine-5-)-Methyltransferase 1, Epigenomics, X Chromosome, Euchromatin, Chromosomal Proteins, Non-Histone, Heterochromatin, Epigenetic code, Retinal Rod Photoreceptor Cells/metabolism/ultrastructure, Histones/metabolism, Chromosomal Proteins, Non-Histone/metabolism, Biology, Retina, X-inactivation, Epigenesis, Genetic, Histones, Mice, Retinal Rod Photoreceptor Cells, X Chromosome Inactivation, Cell Nucleus/*genetics/metabolism/ultrastructure, Genetics, Animals, Histone code, DNA (Cytosine-5-)-Methyltransferases, Euchromatin/*genetics/metabolism/ultrastructure, Cell Nucleus, Mice, Knockout, Heterochromatin/*genetics/metabolism/ultrastructure, DNA Methylation, Molecular biology, Cell biology, Chromatin, Retina/*metabolism, Histone, Sex Chromatin, DNA (Cytosine-5-)-Methyltransferase/metabolism, biology.protein, Heterochromatin protein 1
Abstract

To improve light propagation through the retina, the rod nuclei of nocturnal mammals are uniquely changed compared to the nuclei of other cells. In particular, the main classes of chromatin are segregated in them and form regular concentric shells in order; inverted in comparison to conventional nuclei. A broad study of the epigenetic landscape of the inverted and conventional mouse retinal nuclei indicated several differences between them and several features of general interest for the organization of the mammalian nuclei. In difference to nuclei with conventional architecture, the packing density of pericentromeric satellites and LINE-rich chromatin is similar in inverted rod nuclei; euchromatin has a lower packing density in both cases. A high global chromatin condensation in rod nuclei minimizes the structural difference between active and inactive X chromosome homologues. DNA methylation is observed primarily in the chromocenter, Dnmt1 is primarily associated with the euchromatic shell. Heterochromatin proteins HP1-alpha and HP1-beta localize in heterochromatic shells, whereas HP1-gamma is associated with euchromatin. For most of the 25 studied histone modifications, we observed predominant colocalization with a certain main chromatin class. Both inversions in rod nuclei and maintenance of peripheral heterochromatin in conventional nuclei are not affected by a loss or depletion of the major silencing core histone modifications in respective knock-out mice, but for different reasons. Maintenance of peripheral heterochromatin appears to be ensured by redundancy both at the level of enzymes setting the epigenetic code (writers) and the code itself, whereas inversion in rods rely on the absence of the peripheral heterochromatin tethers (absence of code readers).

Published
2013

127. Capacitive sensing of test mass motion with nanometer precision over millimeter-wide sensing gaps for space-borne gravitational reference sensors

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica, Audley, H., Auger, G., Baird, J., Binetruy, P., Caleno, M., Cesarini, A., Diepholz, I, Dixon, G, Dolesi, R, Ferraioli, L., Heinzel, G, Hollington, D., Karnesis, N., Martín-Porqueras, F., Fernandez Sopuerta, Carlos, Texier, D., Vitale, S., Wanner, G, Ward, Harold, Ramos Castro, Juan José, Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica, Audley, H., Auger, G., Baird, J., Binetruy, P., Caleno, M., Cesarini, A., Diepholz, I, Dixon, G, Dolesi, R, Ferraioli, L., Heinzel, G, Hollington, D., Karnesis, N., Martín-Porqueras, F., Fernandez Sopuerta, Carlos, Texier, D., Vitale, S., Wanner, G, Ward, Harold, and Ramos Castro, Juan José

Abstract

We report on the performance of the capacitive gap-sensing system of the Gravitational Reference Sensor on board the LISA Pathfinder spacecraft. From in-flight measurements, the system has demonstrated a performance, down to 1 mHz, that is ranging between 0.7 and 1.8¿¿aF¿Hz-1/2. That translates into a sensing noise of the test mass motion within 1.2 and 2.4¿¿nm¿Hz-1/2 in displacement and within 83 and 170¿¿nrad¿Hz-1/2 in rotation. This matches the performance goals for LISA Pathfinder, and it allows the successful implementation of the gravitational waves observatory LISA. A 1/f tail has been observed for frequencies below 1 mHz, the tail has been investigated in detail with dedicated in-flight measurements, and a model is presented in the paper. A projection of such noise to frequencies below 0.1 mHz shows that an improvement of performance at those frequencies is desirable for the next generation of gravitational reference sensors for space-borne gravitational waves observation., Peer Reviewed, Postprint (author's final draft)

Published
2017

128. Preliminary results on the suppression of sensing cross-talk in LISA Pathfinder

Author

Wanner, G., Karnesis, N., Wanner, G., and Karnesis, N.

Abstract

In the original paper describing the first measurements performed with LISA Pathfinder, a bulge in the acceleration noise was shown in the 200 mHz - 20 mHz frequency band. This bulge noise originated from cross-coupling of spacecraft motion into the longitudinal readout and it was shown that it is possible to subtract this cross-talk noise. We discuss here the model that was used for subtraction as well as an alternative approach to suppress the cross talk by realignment of the test masses. Such a realignment was performed after preliminary analysis of a dedicated cross-talk experiment, and we show the resulting noise suppression. Since then, further experiments have been performed to investigate the cross-coupling behaviour, however analysis of these experiments is still on-going. © Published under licence by IOP Publishing Ltd.

Published
2017

129. Kepler, Newton and numerical analysis

Author

Wanner, G. and Wanner, G.

Abstract

Numerical methods are usually constructed for solving mathematical problems such as differential equations or optimization problems. In this contribution we discuss the fact that numerical methods, applied inversely, were also important in establishing these models. We show in detail the discovery of the laws of planetary motion by Kepler and Newton, which stood at the beginning of modern science. The 400th anniversary of the publication of Kepler's laws (1609) is a good occasion for this investigation

Published
2017

132. Optical bench development for LISA

Author

Bogenstahl, J., primary, Diekmann, C., primary, Fitzsimons, E. D., primary, Fleddermann, R., primary, Granova, E., primary, Killow, C. J., primary, Pijnenburg, J., primary, Robertson, D. I., primary, Shoda, A., primary, Sohmer, A., primary, Tröbs, M., primary, Ward, H., primary, Weise, D., primary, d'Arcio, L., primary, Dehne, M., primary, Heinzel, G., primary, Hogenhuis, H., primary, Perreur-Lloyd, M., primary, Taylor, A., primary, and Wanner, G., primary

Published
2017
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135. Activation of the heme degradation pathway in severely injured trauma patients

Author

Rittirsch, D, Lindig, S, Schoenborn, V, Wanner, E, Simmen, HP, Claus, R, Bauer, M, and Wanner, G

Subjects
ddc: 610, Bluttransfusion, Sepsis, SIRS, Polytrauma, 610 Medical sciences, Medicine, Hämstoffwechsel
Abstract

Objectives: Trauma and tissue damage trigger an inflammatory response required for postinjury regeneration and tissue repair. In severe trauma, overwhelming systemic inflammation (SIRS) can result in additional damage to host cells and the development of multi-organ failure and sepsis. In the present[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)

Published
2015
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136. Status quo der Boden- und Luftrettung schwerverletzter Patienten

Author

Günkel, S, König, M, Albrecht, R, Brüesch, M, Lefering, R, Sprengel, K, Werner, C M L, Simmen, H-P, Wanner, G A, University of Zurich, and Günkel, S

Subjects
10021 Department of Trauma Surgery, 2732 Orthopedics and Sports Medicine, 610 Medicine & health, 10266 Clinic for Reconstructive Surgery, 2711 Emergency Medicine, 2746 Surgery
Published
2015

137. Bayesian statistics for the calibration of the LISA Pathfinder experiment

Author

Armano, M., Audley, H., Auger, G., Baird, J., Binetruy, P., Born, M., Bortoluzzi, D., Brandt, N., Bursi, A., Caleno, M., Cavalleri, A., Cesarini, A., Cruise, M., Danzmann, K., Diepholz, I., Dolesi, R., Dunbar, N., Ferraioli, L., Ferroni, V., Fitzsimons, E., Freschi, M., Gallegos, J., Marirrodriga, C., Gerndt, R., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grimani, C., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hueller, M., Huesler, J., Inchauspé, H., Jennrich, O., Jetzer, P., Johlander, B., Karnesis, N., Kaune, B., Korsakova, N., Killow, C., Lloro, I., Maarschalkerweerd, R., Madden, S., Mance, D., Martín, V., Martin-Porqueras, F., Mateos, I., McNamara, P., Mendes, J., Mendes, L., Moroni, A., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Prat, P., Ragnit, U., Ramos-Castro, J., Reiche, J., Romera Perez, J., Robertson, D., Rozemeijer, H., Russano, G., Sarra, P., Schleicher, A., Slutsky, J., Sopuerta, C., Sumner, T., Texier, D., Thorpe, J., Trenkel, C., Tu, H., Vitale, S., Wanner, G., Ward, H., Waschke, S., Wass, P., Wealthy, D., Wen, S., Weber, W., Wittchen, A., Zanoni, C., Ziegler, T., and Zweifel, P.

Published
2015

138. A Strategy to Characterize the LISA-Pathfinder Cold Gas Thruster System

Author

Armano, M, Audley, H, Auger, G, Baird, J, Binetruy, P, Born, M, Bortoluzzi, D, Brandt, N, Bursi, A, Caleno, M, Cavalleri, A, Cesarini, A, Cruise, M, Danzmann, K, Diepholz, I, Dolesi, R, Dunbar, N, Ferraioli, L, Ferroni, V, Fitzsimons, E, Freschi, M, Gallegos, J, Marirrodriga, C Garcia, Gerndt, R, Gesa, L I, Gibert, F, Giardini, D, Giusteri, R, Grimani, C, Harrison, I, Heinzel, G, Hewitson, M, Hollington, D, Hueller, M, Huesler, J, Inchauspé, H, Jennrich, O, Jetzer, P, Johlander, B, Karnesis, N, Kaune, B, Korsakova, N, Killow, C., Lloro, I, Maarschalkerweerd, R, Madden, S, Mance, D, Martin, V, Martin-Porqueras, F, Mateos, I, McNamara, P, Mendes, J, Mendes, L, Moroni, A, Nofrarias, M, Paczkowski, S, Perreur-Lloyd, M., Petiteau, A, Pivato, P, Plagnol, E, Prat, P, Ragnit, U, Ramos-Castro, J, Reiche, J, Perez, J A Romera, Robertson, D., Rozemeijer, H, Russano, G, Sarra, P, Schleicher, A, Slutsky, J, Sopuerta, C F, Sumner, T, Texier, D, Thorpe, J, Trenkel, C, Tu, H B, Vitale, S, Wanner, G, Ward, H., Waschke, S, Wass, P, Wealthy, D, Wen, S, Weber, W, Wittchen, A, Zanoni, C, Ziegler, T, and Zweifel, P

Subjects
Astronomy, ddc:530, ddc:500, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, Astrophysics, LISA Pathfinder, Konferenzschrift, Dewey Decimal Classification::500 | Naturwissenschaften, Physics, Applied
Abstract

The cold gas micro-propulsion system that will be used during the LISA-Pathfinder mission will be one of the most important component used to ensure the "free-fall" of the enclosed test masses. In this paper we present a possible strategy to characterize the effective direction and amplitude gain of each of the 6 thrusters of this system. Sorbonne Paric Cite/UnivEarthS Labex French Space Ageny (CNES)

Published
2015
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139. The LISA Pathfinder Mission

Author

Armano, M, Audley, H, Auger, G, Baird, J, Binetruy, P, Born, M, Bortoluzzi, D, Brandt, N, Bursi, A, Caleno, M, Cavalleri, A, Cesarini, A, Cruise, M, Danzmann, K, Diepholz, I, Dolesi, R, Dunbar, N, Ferraioli, L, Ferroni, V, Fitzsimons, E, Freschi, M, Gallegos, J, Marirrodriga, C García, Gerndt, R, Gesa, L I, Gibert, F, Giardini, D, Giusteri, R, Grimani, C, Harrison, I, Heinzel, G, Hewitson, M, Hollington, D, Hueller, M, Huesler, J, Inchauspé, H, Jennrich, O, Jetzer, P, Johlander, B, Karnesis, N, Kaune, B, Korsakova, N, Killow, C., Lloro, I, Maarschalkerweerd, R, Madden, S, Mance, D, Martín, V, Martin-Porqueras, F, Mateos, I, McNamara, P, Mendes, J, Mendes, L, Moroni, A, Nofrarias, M, Paczkowski, S, Perreur-Lloyd, M., Petiteau, A, Pivato, P, Plagnol, E, Prat, P, Ragnit, U, Ramos-Castro, J, Reiche, J, Perez, J A Romera, Robertson, D., Rozemeijer, H, Russano, G, Sarra, P, Schleicher, A, Slutsky, J, Sopuerta, C F, Sumner, T, Texier, D, Thorpe, J, Trenkel, C, Tu, H B, Vetrugno, D, Vitale, S, Wanner, G, Ward, H., Waschke, S, Wass, P, Wealthy, D, Wen, S, Weber, W, Wittchen, A, Zanoni, C, Ziegler, T, and Zweifel, P

Subjects
History, Critical technologies, Lisa technology packages, Gravity waves, Propulsion, 01 natural sciences, 7. Clean energy, Education, Gravitational wave detectors, Gravitational-wave detection, 0103 physical sciences, ddc:530, Free flight, 010303 astronomy & astrophysics, Konferenzschrift, Physical principles, 010308 nuclear & particles physics, Gravitational effects, Measurement concepts, Technology validations, Computer Science Applications, Low pass filters, Inertial navigation systems, European Space Agency, Space probes, Gravitation
Abstract

ISA Pathfinder (LPF), the second of the European Space Agency's Small Missions for Advanced Research in Technology (SMART), is a dedicated technology validation mission for future spaceborne gravitational wave detectors, such as the proposed eLISA mission. LISA Pathfinder, and its scientific payload - the LISA Technology Package - will test, in flight, the critical technologies required for low frequency gravitational wave detection: it will put two test masses in a near-perfect gravitational free-fall and control and measure their motion with unprecedented accuracy. This is achieved through technology comprising inertial sensors, high precision laser metrology, drag-free control and an ultra-precise micro-Newton propulsion system. LISA Pathfinder is due to be launched in mid-2015, with first results on the performance of the system being available 6 months thereafter.\ud \ud The paper introduces the LISA Pathfinder mission, followed by an explanation of the physical principles of measurement concept and associated hardware. We then provide a detailed discussion of the LISA Technology Package, including both the inertial sensor and interferometric readout. As we approach the launch of the LISA Pathfinder, the focus of the development is shifting towards the science operations and data analysis - this is described in the final section of the paper.

Published
2015

140. A Strategy to Characterize the LISA-Pathfinder Cold Gas Thruster System

Author

Armano, M., Audley, H., Auger, G., Baird, J., Binetruy, P., Born, M., Bortoluzzi, D., Brandt, N., Bursi, A., Caleno, M., Cavalleri, A., Cesarini, A., Cruise, M., Cutler, C., Danzmann, K., Diepholz, I., Dolesi, R., Dunbar, N., Ferraioli, L., Ferroni, V., Fitzsimons, E., Freschi, M., Gallegos, J., Marirrodriga, C., Gerndt, R., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grimani, C., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hueller, M., Huesler, J., Inchauspe, H., Jennrich, O., Jetzer, P., Johlander, B., Karnesis, N., Kaune, B., Korsakova, N., Killow, C., Lloro, I., Maarschalkerweerd, R., Madden, S., Maghami, P., Mance, D., Martin, V., Martin-Porqueras, F., Mateos, I., McNamara, P., Mendes, J., Mendes, L., Moroni, A., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Prat, P., Ragnit, U., Ramos-Castro, J., Reiche, J., Perez, J., Robertson, D., Rozemeijer, H., Russano, G., Sarra, P., Schleicher, A., Slutsky, J., Sopuerta, C., Sumner, T., Texier, D., Thorpe, J., Trenkel, C., Tu, H., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Waschke, S., Wass, P., Wealthy, D., Wen, S., Weber, W., Wittchen, A., Zanoni, C., Ziegler, T., and Zweifel, P.

Subjects
Physics, History, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics, Cold gas thruster, Computer Science Applications, Education, Pathfinder, Amplitude, Component (UML), Physics::Space Physics, Aerospace engineering, business
Abstract

The LISA Pathfinder mission will demonstrate the technology of drag-free test masses for use as inertial references in future space-based gravitational wave detectors. To accomplish this, the Pathfinder spacecraft will perform drag-free flight about a test mass while measuring the acceleration of this primary test mass relative to a second reference test mass. Because the reference test mass is contained within the same spacecraft, it is necessary to apply forces on it to maintain its position and attitude relative to the spacecraft. These forces are a potential source of acceleration noise in the LISA Pathfinder system that are not present in the full LISA configuration. While LISA Pathfinder has been designed to meet it's primary mission requirements in the presence of this noise, recent estimates suggest that the on-orbit performance may be limited by this `suspension noise'. The drift-mode or free-flight experiments provide an opportunity to mitigate this noise source and further characterize the underlying disturbances that are of interest to the designers of LISA-like instruments. This article provides a high-level overview of these experiments and the methods under development to analyze the resulting data.

Published
2015

141. OPTICAL BENCH DEVELOPMENT FOR LISA.

Author

d'Arcio, L., Bogenstahl, J., Dehne, M., Diekmann, C., Fitzsimons, E. D., Fleddermann, R., Granova, E., Heinzel, G., Hogenhuis, H., Killow, C. J., Perreur-Lloyd, M., Pijnenburg, J., Robertson, D. I., Shoda, A., Sohmer, A., Taylor, A., Tröbs, M., Wanner, G., Ward, H., and Weise, D.

Published
2017
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142. Cell cycle-regulated PLEIADE/AtMAP65-3 links membrane and microtubule dynamics during plant cytokinesis

Author

Steiner, A, Rybak, K, Altmann, M, McFarlane, HE, Klaeger, S, Ngoc, N, Facher, E, Ivakov, A, Wanner, G, Kuster, B, Persson, S, Braun, P, Hauser, M-T, Assaad, FF, Steiner, A, Rybak, K, Altmann, M, McFarlane, HE, Klaeger, S, Ngoc, N, Facher, E, Ivakov, A, Wanner, G, Kuster, B, Persson, S, Braun, P, Hauser, M-T, and Assaad, FF

Abstract

Cytokinesis, the partitioning of the cytoplasm following nuclear division, requires extensive coordination between cell cycle cues, membrane trafficking and microtubule dynamics. Plant cytokinesis occurs within a transient membrane compartment known as the cell plate, to which vesicles are delivered by a plant-specific microtubule array, the phragmoplast. While membrane proteins required for cytokinesis are known, how these are coordinated with microtubule dynamics and regulated by cell cycle cues remains unclear. Here, we document physical and genetic interactions between Transport Protein Particle II (TRAPPII) tethering factors and microtubule-associated proteins of the PLEIADE/AtMAP65 family. These interactions do not specifically affect the recruitment of either TRAPPII or MAP65 proteins to the cell plate or midzone. Rather, and based on single versus double mutant phenotypes, it appears that they are required to coordinate cytokinesis with the nuclear division cycle. As MAP65 family members are known to be targets of cell cycle-regulated kinases, our results provide a conceptual framework for how membrane and microtubule dynamics may be coordinated with each other and with the nuclear cycle during plant cytokinesis.

Published
2016

144. Kommentar zu Faustregel 5 aus PRAXIS Nr. 13

Author

Wanner, G A, University of Zurich, and Wanner, G A

Subjects
10022 Division of Surgical Research, 610 Medicine & health, 2700 General Medicine, General Medicine
Published
2009

146. Der Einfluss von induzierter Hypothermie auf die Transfusionsrate und die Letalität schwerverletzter Patienten

Author

Jensen, KO, Angst, S, Kraus, A, Mommsen, P, Hildebrand, F, Wanner, G, Simmen, HP, and Sprengel, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Hypothermie ist eine etablierte, jedoch kontrovers diskutierte Therapie in der Postreanimationsphase nach Herzstillstand und bei der Behandlung des schweren Schädel-Hirn-Traumas. Insbesondere der Einfluss auf Blutgerinnung und Blutungsneigung ist nicht hinreichend geklärt. Ziel[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014)

Published
2014
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147. Einfluss des Prehospital Trauma Life Support (PHTLS ® ) -Trainings auf das präklinische Management und die Mortalität schwerverletzter Patienten

Author

Sprengel, K, Isler, A, Löhr, N, Brüesch, M, Rittirsch, D, Werner, C, Simmen, HP, and Wanner, G

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Das strukturierte präklinische Versorgungskonzept des Unfallverletzten gemäss PHTLS® zielt auf einen möglichst raschen Transport zur definitiven Versorgung in eine geeignete Zielklinik unter Fokussierung auf die zur Lebensrettung absolut wichtigsten Massnahmen. Während[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014)

Published
2014
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148. Klinisches Ergebnis nach offener Reposition und Fixierung von Frakturen des distalen Radius unter Verwendung von palmaren distalen Zwei-Säulen LCP mit variablem Verriegelungswinkel

Author

Schäfer, FP, Günkel, S, Wanner, G, and Simmen, HP

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Die distale Radiusfraktur ist eine der häufigsten Frakturen des Menschen und ein großer Bestandteil der täglichen Praxis eines Unfallchirurgen. Aktuell stehen vielfältige Versorgungsmöglichkeiten mit einer Großzahl an verschiedenen Osteosynthesesystemen zur[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014)

Published
2014
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149. Constraints on LISA Pathfinder’s self-gravity: design requirements, estimates and testing procedures

Author

Armano, M, primary, Audley, H, additional, Auger, G, additional, Baird, J, additional, Binetruy, P, additional, Born, M, additional, Bortoluzzi, D, additional, Brandt, N, additional, Bursi, A, additional, Caleno, M, additional, Cavalleri, A, additional, Cesarini, A, additional, Cruise, M, additional, Danzmann, K, additional, Silva, M de Deus, additional, Desiderio, D, additional, Piersanti, E, additional, Diepholz, I, additional, Dolesi, R, additional, Dunbar, N, additional, Ferraioli, L, additional, Ferroni, V, additional, Fitzsimons, E, additional, Flatscher, R, additional, Freschi, M, additional, Gallegos, J, additional, Marirrodriga, C García, additional, Gerndt, R, additional, Gesa, L, additional, Gibert, F, additional, Giardini, D, additional, Giusteri, R, additional, Grimani, C, additional, Grzymisch, J, additional, Harrison, I, additional, Heinzel, G, additional, Hewitson, M, additional, Hollington, D, additional, Hueller, M, additional, Huesler, J, additional, Inchauspé, H, additional, Jennrich, O, additional, Jetzer, P, additional, Johlander, B, additional, Karnesis, N, additional, Kaune, B, additional, Korsakova, N, additional, Killow, C, additional, Lloro, I, additional, Liu, L, additional, López-Zaragoza, J P, additional, Maarschalkerweerd, R, additional, Madden, S, additional, Mance, D, additional, Martín, V, additional, Martin-Polo, L, additional, Martino, J, additional, Martin-Porqueras, F, additional, Mateos, I, additional, McNamara, P W, additional, Mendes, J, additional, Mendes, L, additional, Moroni, A, additional, Nofrarias, M, additional, Paczkowski, S, additional, Perreur-Lloyd, M, additional, Petiteau, A, additional, Pivato, P, additional, Plagnol, E, additional, Prat, P, additional, Ragnit, U, additional, Ramos-Castro, J, additional, Reiche, J, additional, Perez, J A Romera, additional, Robertson, D, additional, Rozemeijer, H, additional, Rivas, F, additional, Russano, G, additional, Sarra, P, additional, Schleicher, A, additional, Slutsky, J, additional, Sopuerta, C F, additional, Sumner, T, additional, Texier, D, additional, Thorpe, J I, additional, Tomlinson, R, additional, Trenkel, C, additional, Vetrugno, D, additional, Vitale, S, additional, Wanner, G, additional, Ward, H, additional, Warren, C, additional, Wass, P J, additional, Wealthy, D, additional, Weber, W J, additional, Wittchen, A, additional, Zanoni, C, additional, Ziegler, T, additional, and Zweifel, P, additional

Published
2016
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150. Sub-Femto-gFree Fall for Space-Based Gravitational Wave Observatories: LISA Pathfinder Results

Author

Armano, M., primary, Audley, H., additional, Auger, G., additional, Baird, J. T., additional, Bassan, M., additional, Binetruy, P., additional, Born, M., additional, Bortoluzzi, D., additional, Brandt, N., additional, Caleno, M., additional, Carbone, L., additional, Cavalleri, A., additional, Cesarini, A., additional, Ciani, G., additional, Congedo, G., additional, Cruise, A. M., additional, Danzmann, K., additional, de Deus Silva, M., additional, De Rosa, R., additional, Diaz-Aguiló, M., additional, Di Fiore, L., additional, Diepholz, I., additional, Dixon, G., additional, Dolesi, R., additional, Dunbar, N., additional, Ferraioli, L., additional, Ferroni, V., additional, Fichter, W., additional, Fitzsimons, E. D., additional, Flatscher, R., additional, Freschi, M., additional, García Marín, A. F., additional, García Marirrodriga, C., additional, Gerndt, R., additional, Gesa, L., additional, Gibert, F., additional, Giardini, D., additional, Giusteri, R., additional, Guzmán, F., additional, Grado, A., additional, Grimani, C., additional, Grynagier, A., additional, Grzymisch, J., additional, Harrison, I., additional, Heinzel, G., additional, Hewitson, M., additional, Hollington, D., additional, Hoyland, D., additional, Hueller, M., additional, Inchauspé, H., additional, Jennrich, O., additional, Jetzer, P., additional, Johann, U., additional, Johlander, B., additional, Karnesis, N., additional, Kaune, B., additional, Korsakova, N., additional, Killow, C. J., additional, Lobo, J. A., additional, Lloro, I., additional, Liu, L., additional, López-Zaragoza, J. P., additional, Maarschalkerweerd, R., additional, Mance, D., additional, Martín, V., additional, Martin-Polo, L., additional, Martino, J., additional, Martin-Porqueras, F., additional, Madden, S., additional, Mateos, I., additional, McNamara, P. W., additional, Mendes, J., additional, Mendes, L., additional, Monsky, A., additional, Nicolodi, D., additional, Nofrarias, M., additional, Paczkowski, S., additional, Perreur-Lloyd, M., additional, Petiteau, A., additional, Pivato, P., additional, Plagnol, E., additional, Prat, P., additional, Ragnit, U., additional, Raïs, B., additional, Ramos-Castro, J., additional, Reiche, J., additional, Robertson, D. I., additional, Rozemeijer, H., additional, Rivas, F., additional, Russano, G., additional, Sanjuán, J., additional, Sarra, P., additional, Schleicher, A., additional, Shaul, D., additional, Slutsky, J., additional, Sopuerta, C. F., additional, Stanga, R., additional, Steier, F., additional, Sumner, T., additional, Texier, D., additional, Thorpe, J. I., additional, Trenkel, C., additional, Tröbs, M., additional, Tu, H. B., additional, Vetrugno, D., additional, Vitale, S., additional, Wand, V., additional, Wanner, G., additional, Ward, H., additional, Warren, C., additional, Wass, P. J., additional, Wealthy, D., additional, Weber, W. J., additional, Wissel, L., additional, Wittchen, A., additional, Zambotti, A., additional, Zanoni, C., additional, Ziegler, T., additional, and Zweifel, P., additional

Published
2016
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