510 results on '"Wanke, Isabel"'
Search Results
102. Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke
- Author
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Saver, Jeffrey L, Goyal, Mayank, Bonafe, Alain, Diener, Hans Christoph, Levy, Elad I, Pereira, Vitor M, Albers, Gregory W, Cognard, Christophe, Cohen, David J, Hacke, Werner, Jansen, Olav, Jovin, Tudor G, Mattle, Heinrich P, Nogueira, Raul G, Siddiqui, Adnan H, Yavagal, Dileep R, Baxter, Blaise W, Devlin, Thomas G, Lopes, Demetrius K, Reddy, Vivek K, du Mesnil de Rochemont, Richard, Singer, Oliver C, Jahan, Reza, Devlin, T, Baxter, B, Hawk, H, Sapkota, B, Quarfordt, S, Sirelkhatim, A, Dellinger, C, Barton, K, Reddy, V K, Jovin, T G, Ducruet, A, Jadhav, A, Horev, A, Giurgiutiu, D-V, Totoraitis, V, Hammer, M, Jankowitz, B, Wechsler, L, Rocha, M, Gulati, D, Campbell, D, Star, M, Baxendell, L, Oakley, J, Siddiqui, A H, Hopkins, L N, Levy, E, Snyder, K, Sawyer, R, Hall, S, Bonafé, A, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, de Champfleur, N Menjot, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, S-J, Lescher, S, Braun, H, Nogueira, R G, Dehkharghani, S, Belagaje, S R, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, D K, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, J S, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, Marc, Göricke, Sophia Luise, Ringlestein, A, Wanke, Isabel, Mönninghoff, Christoph, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, W J, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, M S, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, R D, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, L S, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, J T, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-F M, Zaidat, O, Lynch, J R, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Lara, J F Arenillas, Galdámez, M Martínez, Sanz, A I Calleja, Garcia, E Cortijo, Bermejo, P Garcia, Perez, S, Carrillo, P Mulero, Vallejo, E Crespo, Piñero, M Ruiz, Mesonero, L Lopez, Muñoz, F J Reyes, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Yavagal, D R, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ayudarte, N Ruiz de Morales, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, J G, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, L H, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, B D, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, M L, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henniger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, J D, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, University of California [Los Angeles] (UCLA), University of California, Département de Neuroradiologie[Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and CHU Toulouse [Toulouse]
- Subjects
Male ,medicine.medical_specialty ,Solitaire Cryptographic Algorithm ,Randomization ,Medizin ,610 Medicine & health ,Brain Ischemia ,law.invention ,Fibrinolytic Agents ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Randomized controlled trial ,Modified Rankin Scale ,law ,medicine ,Humans ,Intravenous tissue plasminogen activator ,Stroke ,Aged ,Thrombectomy ,Stent retriever ,Groin ,business.industry ,Endovascular Procedures ,General Medicine ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,3. Good health ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Tissue Plasminogen Activator ,Acute Disease ,Administration, Intravenous ,Female ,Stents ,business - Abstract
BACKGROUND: Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy with the use of a stent retriever, in addition to intravenous t-PA, increases reperfusion rates and may improve long-term functional outcome.METHODS: We randomly assigned eligible patients with stroke who were receiving or had received intravenous t-PA to continue with t-PA alone (control group) or to undergo endovascular thrombectomy with the use of a stent retriever within 6 hours after symptom onset (intervention group). Patients had confirmed occlusions in the proximal anterior intracranial circulation and an absence of large ischemic-core lesions. The primary outcome was the severity of global disability at 90 days, as assessed by means of the modified Rankin scale (with scores ranging from 0 [no symptoms] to 6 [death]).RESULTS: The study was stopped early because of efficacy. At 39 centers, 196 patients underwent randomization (98 patients in each group). In the intervention group, the median time from qualifying imaging to groin puncture was 57 minutes, and the rate of substantial reperfusion at the end of the procedure was 88%. Thrombectomy with the stent retriever plus intravenous t-PA reduced disability at 90 days over the entire range of scores on the modified Rankin scale (PCONCLUSIONS: In patients receiving intravenous t-PA for acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, thrombectomy with a stent retriever within 6 hours after onset improved functional outcomes at 90 days. (Funded by Covidien; SWIFT PRIME ClinicalTrials.gov number, NCT01657461.).
- Published
- 2015
103. Using shape descriptors to categorize intracranial aneurysms
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Juchler, Norman, Schilling, Sabine, Wanke, Isabel, Rüfenacht, Daniel, Bijlenga, Philippe, Kurtcuoglu, Vartan, Hirsch, Sven, Juchler, Norman, Schilling, Sabine, Wanke, Isabel, Rüfenacht, Daniel, Bijlenga, Philippe, Kurtcuoglu, Vartan, and Hirsch, Sven
- Abstract
Working towards a system to match intracranial aneurysms of similar morphology, we examine how a variety of established shape descriptors relate to expert assessments of aneurysm morphology. For this purpose, we extract 3D models of aneurysms from 3D angiographies and calculate numerical values (geometry indices and moment invariants) that describe the size and shape of the aneurysm and the surrounding arteries. We then compare these shape descriptors with human assessments of qualitative morphological characteristics like irregularity or the presence/absence of blebs. Here, we present preliminary results based on 137 aneurysm models.
- Published
- 2018
104. Shape-based modeling of aneurysmal disease status
- Author
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Juchler, Norman, Schilling, Sabine, Wanke, Isabel, Rüfenacht, Daniel, Bijlenga, Philippe, Kurtcuoglu, Vartan, Hirsch, Sven, Juchler, Norman, Schilling, Sabine, Wanke, Isabel, Rüfenacht, Daniel, Bijlenga, Philippe, Kurtcuoglu, Vartan, and Hirsch, Sven
- Abstract
Introduction: To date, it is difficult for clinicians to judge the associated risks of intracranial aneurysms reliably. Because the 3D-shape of an aneurysm is strongly linked to the underlying formation processes it is very likely that the presence or absence of certain shape features indicate the disease status of the aneurysm. Shape (extracted from medical imaging data) already plays a significant role in the qualitative assessment of the aneurysm by the clinician and has been associated with risk prediction. Still, no consensus exists about which shape features reliably predict instability or whether there exist any that qualify as biomarkers at all. In an effort to find support for the assumption that aneurysm shape carries information about the aneurysm status, we developed a flexible classification pipeline that extracts shape features and tests their applicability. Methods: 3D models of aneurysms are extracted from medical imaging data (mostly 3DRA) by a standardized vessel segmentation method. The aneurysm is cut from its parent vessels according to a simple and reproducible cut protocol. Different representations of the 3D shape that have been suggested by literature are calculated for the extracted aneurysm. So far we have looked at Zernike moments (ZM), their invariants (ZMI) and simple geometry indices such as undulation or non-sphericity. Different feature reduction techniques (for ZMI) and machine-learning methods are applied to find linking patterns between shape features and aneurysm stability. This processing pipeline is applied to a relatively large clinical dataset (ca. 400 cases), whereas the collection of new cases is an on-going effort. We will present the findings on the latest state of the database. Results: Initial results indicate that the ZMI alone are insufficient to classify aneurysms reliably in terms of rupture or stability status. Because of their global support, ZMI bare a strong dependency on the placement of the cuts. In a prelimin
- Published
- 2018
105. Where does CFD identify lesion instability in small aneurysms?
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Anzai, Hitomi, Juchler, Norman, Ohta, Makoto, Hirsch, Sven, Rüfenacht, Daniel A., Wanke, Isabel, Anzai, Hitomi, Juchler, Norman, Ohta, Makoto, Hirsch, Sven, Rüfenacht, Daniel A., and Wanke, Isabel
- Abstract
In our observation, wall enhancement MRI allows for directly identifying areas of disturbed contrast permeability, i.e. inflammation, thrombus or a combination of both, and thus visualizes areas of instability in the aneurysm wall. In presented cases, regions of enhancements were compared with wall shear stress (WSS) distribution obtained from computational fluid dynamics (CFD). In our findings, areas of wall enhancement match well with either low or high WSS, however, other areas of low or high WSS were observed without identification of any wall enhancement.
- Published
- 2018
106. Clinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape
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Hirsch, Sven, Egger, Julian, Wanke, Isabel, Kulcsar, Zsolt, Rüfenacht, Daniel, Hirsch, Sven, Egger, Julian, Wanke, Isabel, Kulcsar, Zsolt, and Rüfenacht, Daniel
- Abstract
We present a clinical perspective, supported by biological findings, reflecting the potential of computational tools to understand and treat intracranial aneurysms. Thrombus formation and chronic inflammation are integral to disease progression, driven by blood flow energy. The interplay between flow energy, blood clotting and remodeling of the tissue is key to an enhanced disease understanding, to improve patient counseling and ultimately endovascular treatment planning. Current concepts suggest that blood governs wall remodeling by multiple biological steps. The process starts with flow induced thrombus adhesion (atherothrombosis) to the wall that secondarily leads to the release of biological mediators of inflammation entertaining destructive remodeling. Destructive wall remodeling jeopardizes the mechanical wall integrity with ensuing circumscribed softening and expansion of the aneurysm shape. The shape of an aneurysm is the visible result of these complex pathological processes and characterizes its disease status. Wall adherent thrombus formation, inflammatory reactions and the driving force of blood flow cause lumen shape changes. Here, shape irregularity is a distinctive sign of focal wall weakening. The integration of shape-analysis,vascular biology and phenotypical information will allow for personalized characterization of aneurysmal vascular disease and help to identify and establish shape as an image-based biomarker. Future translational efforts should aim at providing adequate IT tools and contributing to validation and disease understanding. Ensuing results will have a high likelihood to impact significantly on current clinical disease management.
- Published
- 2018
107. TNM staging with FDG-PET/CT in patients with primary head and neck cancer
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Veit-Haibach, Patrick, Luczak, Christopher, Wanke, Isabel, Fischer, Markus, Egelhof, Thomas, Beyer, Thomas, Dahmen, Gerlinde, Bockisch, Andreas, Rosenbaum, Sandra, Antoch, Gerald, Veit-Haibach, Patrick, Luczak, Christopher, Wanke, Isabel, Fischer, Markus, Egelhof, Thomas, Beyer, Thomas, Dahmen, Gerlinde, Bockisch, Andreas, Rosenbaum, Sandra, and Antoch, Gerald
- Abstract
Purpose: PET/CT, PET+CT, and CT were compared concerning accuracies in TNM staging and malignancy detection in head and neck cancer. The impact of PET/CT compared to the other imaging modalities on therapy management was assessed. Materials and methods: Fifty-five patients with suspected head and neck primary cancer underwent whole-body FDG-PET/CT. PET/CT and PET+CT were evaluated by a nuclear medicine physician and a radiologist; CT was evaluated by two radiologists, PET by two nuclear physicians. Histopathology served as the standard of reference. Differences between the staging modalities were tested for statistical significance by McNemar's test. Results: Overall TNM-staging and T-staging with PET/CT were more accurate than PET+CT and CT alone (p < 0.05). PET/CT was marginally more accurate than CT alone in N-staging (p = 0.04); no statistically significant difference was found when compared to PET+CT for N-staging. PET/CT altered further treatment in 13 patients compared to CT only and in 7 patients compared to PET+CT. Conclusion: Combined PET/CT proved to be partly more accurate in assessing the overall TNM-stage than CT and PET+CT. These results were based on a higher accuracy concerning the T-stage, mainly in patients with metallic implants and marginally the N-stage. Therapy decisions have been influenced in a substantial number of patients. PET/CT might be considered as a first line diagnostic tool in patients with suspected primary head and neck cancer
- Published
- 2018
108. Flow diversion treatment: intra-aneurismal blood flow velocity and WSS reduction are parameters to predict aneurysm thrombosis
- Author
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Kulcsár, Zsolt, Augsburger, Luca, Reymond, Philippe, Pereira, Vitor, Hirsch, Sven, Mallik, Ajit, Millar, John, Wetzel, Stephan, Wanke, Isabel, Rüfenacht, Daniel, Kulcsár, Zsolt, Augsburger, Luca, Reymond, Philippe, Pereira, Vitor, Hirsch, Sven, Mallik, Ajit, Millar, John, Wetzel, Stephan, Wanke, Isabel, and Rüfenacht, Daniel
- Abstract
Background: To evaluate the haemodynamic changes induced by flow diversion treatment in cerebral aneurysms, resulting in thrombosis or persisting aneurysm patency over time. Method: Eight patients with aneurysms at the para-ophthalmic segment of the internal carotid artery were treated by flow diversion only. The clinical follow-up ranged between 6days and 12months. Computational fluid dynamics (CFD) analysis of pre- and post-treatment conditions was performed in all cases. True geometric models of the flow diverter were created and placed over the neck of the aneurysms by using a virtual stent-deployment technique, and the device was simulated as a true physical barrier. Pre- and post-treatment haemodynamics were compared, including mean and maximal velocities, wall-shear stress (WSS) and intra-aneurysmal flow patterns. The CFD study results were then correlated to angiographic follow-up studies. Results: Mean intra-aneurysmal flow velocities and WSS were significantly reduced in all aneurysms. Changes in flow patterns were recorded in only one case. Seven of eight aneurysms showed complete occlusion during the follow-up. One aneurysm remaining patent after 1year showed no change in flow patterns. One aneurysm rupturing 5days after treatment showed also no change in flow pattern, and no change in the maximal inflow velocity. Conclusions: Relative flow velocity and WSS reduction in and of itself may result in aneurysm thrombosis in the majority of cases. Flow reductions under aneurysm-specific thresholds may, however, be the reason why some aneurysms remain completely or partially patent after flow diversion
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- 2018
109. Where does CFD identify lesion instability in small aneurysms?
- Author
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Anzai, Hitomi, Juchler, Norman, Ohta, Makoto, Hirsch, Sven, Rüfenacht, Daniel A., and Wanke, Isabel
- Subjects
Lesion stability ,cardiovascular system ,Intracranial aneurysms ,CFD ,616: Innere Medizin und Krankheiten ,circulatory and respiratory physiology ,Wall enhancement - Abstract
In our observation, wall enhancement MRI allows for directly identifying areas of disturbed contrast permeability, i.e. inflammation, thrombus or a combination of both, and thus visualizes areas of instability in the aneurysm wall. In presented cases, regions of enhancements were compared with wall shear stress (WSS) distribution obtained from computational fluid dynamics (CFD). In our findings, areas of wall enhancement match well with either low or high WSS, however, other areas of low or high WSS were observed without identification of any wall enhancement.
- Published
- 2017
110. Using shape descriptors to categorize intracranial aneurysms
- Author
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Juchler, Norman, Schilling, Sabine, Wanke, Isabel, Rüfenacht, Daniel, Bijlenga, Philippe, Kurtcuoglu, Vartan, and Hirsch, Sven
- Subjects
Morphology ,cardiovascular system ,Shape matching ,cardiovascular diseases ,Intracranial aneurysms ,616: Innere Medizin und Krankheiten - Abstract
Working towards a system to match intracranial aneurysms of similar morphology, we examine how a variety of established shape descriptors relate to expert assessments of aneurysm morphology. For this purpose, we extract 3D models of aneurysms from 3D angiographies and calculate numerical values (geometry indices and moment invariants) that describe the size and shape of the aneurysm and the surrounding arteries. We then compare these shape descriptors with human assessments of qualitative morphological characteristics like irregularity or the presence/absence of blebs. Here, we present preliminary results based on 137 aneurysm models.
- Published
- 2017
111. Shape-based modeling of aneurysmal disease status
- Author
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Juchler, Norman, Schilling, Sabine, Wanke, Isabel, Rüfenacht, Daniel, Bijlenga, Philippe, Kurtcuoglu, Vartan, and Hirsch, Sven
- Subjects
Shape-based risk assessment ,003: Systeme ,cardiovascular system ,Intracranial aneurysms ,616: Innere Medizin und Krankheiten - Abstract
Introduction: To date, it is difficult for clinicians to judge the associated risks of intracranial aneurysms reliably. Because the 3D-shape of an aneurysm is strongly linked to the underlying formation processes it is very likely that the presence or absence of certain shape features indicate the disease status of the aneurysm. Shape (extracted from medical imaging data) already plays a significant role in the qualitative assessment of the aneurysm by the clinician and has been associated with risk prediction. Still, no consensus exists about which shape features reliably predict instability or whether there exist any that qualify as biomarkers at all. In an effort to find support for the assumption that aneurysm shape carries information about the aneurysm status, we developed a flexible classification pipeline that extracts shape features and tests their applicability. Methods: 3D models of aneurysms are extracted from medical imaging data (mostly 3DRA) by a standardized vessel segmentation method. The aneurysm is cut from its parent vessels according to a simple and reproducible cut protocol. Different representations of the 3D shape that have been suggested by literature are calculated for the extracted aneurysm. So far we have looked at Zernike moments (ZM), their invariants (ZMI) and simple geometry indices such as undulation or non-sphericity. Different feature reduction techniques (for ZMI) and machine-learning methods are applied to find linking patterns between shape features and aneurysm stability. This processing pipeline is applied to a relatively large clinical dataset (ca. 400 cases), whereas the collection of new cases is an on-going effort. We will present the findings on the latest state of the database. Results: Initial results indicate that the ZMI alone are insufficient to classify aneurysms reliably in terms of rupture or stability status. Because of their global support, ZMI bare a strong dependency on the placement of the cuts. In a preliminary study, ZMI were only slightly superior regarding rupture prediction compared to much simpler geometry indices. Conclusions: We implemented a framework to test the performance of different combinations of shape features and machine learning techniques. While the shape-only representation of an aneurysm does carry information about its disease status, the classification results will benefit from the stratification of the aneurysms in terms of location, size and clinical factors.
- Published
- 2016
112. Automatic determination of white matter hyperintensity properties in relation to the development of Alzheimer's disease
- Author
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van der Velden, Sandra, Moenninghoff, Christoph, Wanke, Isabel, Jokisch, Martha, Weimar, Christian, Lopes Simoes, Rita, van Cappellen van Walsum, Anne-Marie, Slump, Cornelis, Tourassi, Georgia D., and Armato, Samuel G.
- Subjects
medicine.medical_specialty ,Automatic ,Medizin ,Disease ,030204 cardiovascular system & hematology ,Lesion load ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,White matter hyperintensities ,Dementia ,Cognitive impairment ,business.industry ,Ventricular wall ,Mild cognitive impairment ,Alzheimer's disease ,medicine.disease ,Hyperintensity ,Computer aided diagnosis ,White matter hyperintensity ,Cardiology ,business ,030217 neurology & neurosurgery ,MRI ,Quantitative - Abstract
Alzheimer's disease (AD) is the most common form of dementia seen in the elderly. No curing medicine for AD exists at this moment. In the search for an effective medicine, research is directed towards the prediction of conversion of mild cognitive impairment (MCI) to AD. White matter hyperintensities (WMHs) have been shown to contain information regarding the development of AD, although non-conclusive results are found in literature. These studies often use qualitative measures to describe WMHs, which is time consuming and prone to variability. To investigate the relation between WMHs and the development of AD, algorithms to automatically determine quantitative properties in terms of volume and spatial distribution of WMHs are developed and compared between normal controls and MCI subjects. MCI subjects have a significantly higher total volume of WMHs than normal controls. This difference persists when lesions are classified according to their distance to the ventricular wall. Spatial distribution is also described by defining different brain regions based on a common coordinate system. This reveals that MCI subjects have a larger WMH volume in the upper part of the brain compared to normal controls. In four subjects, the change of WMH properties over time is studied in detail. Although such a small dataset cannot be used to give definitive conclusions, the data suggests that progression of WMHs in subjects with a low lesion load is caused by an increase in the number of lesions and by the progression of juxtacortical lesions. In subjects with a larger lesion load, progression is caused by expansion of pre-existing lesions.
- Published
- 2016
113. Neuroradiologie et neurochirurgie: Anévrisme intracrânien de découverte fortuite
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Wanke, Isabel, primary, Bijlenga, Philippe, additional, and Rüfenacht, Daniel A., additional
- Published
- 2017
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114. Neuroradiologie und Neurochirurgie: Zufallsbefund intrakranielles Aneurysma
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Wanke, Isabel, primary, Bijlenga, Philippe, additional, and Rüfenacht, Daniel A., additional
- Published
- 2017
- Full Text
- View/download PDF
115. Multiple cerebral arterio-venous malformations: Distinct entity or simple multiplication?
- Author
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Stein, Klaus-Peter, Wanke, Isabel, Zhu, Yuan, Oezkan, Neriman, Schoemberg, Tobias, Sandalcioglu, I. Erol, and Sure, Ulrich
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ddc: 610 ,AVM Multiplicity ,Arteriovenous Malformation ,Hemorrhage ,610 Medical sciences ,Medicine ,humanities - Abstract
Objective: To present clinical, angiographical and therapeutical characteristics of patients with sporadic multiple AVMs, treated in our institution. Method: Patients with cerebral AVMs, treated in our department between 1990 and 2013, were analyzed retrospectively. Basic demographic data, vascular[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
- Published
- 2015
- Full Text
- View/download PDF
116. Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis
- Author
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Dengler, Julius, Maldaner, Nicolai, Bijlenga, Philippe, Burkhardt, Jan-Karl, Graewe, Alexander, Guhl, Susanne, Hong, Bujung, Hohaus, Christian, Kursumovic, Adisa, Mielke, Dorothee, Schebesch, Karl-Michael, Wostrack, Maria, Rufenacht, Daniel, Vajkoczy, Peter, Schmidt, Nils Ole, Vajkoczy, P, Maldaner, N, Uebelacker, A, Dengler, J, Endres, M, Bohner, G, Wiener, E, Bauknecht, H C, Heuschmann, P U, Malzahn, U, Gläsker, S, Zentner, J, Van Velthoven, V, Guhl, S, Schroeder, Werner, Strowitzki, M, Etminan, N, Haengghi, D, Eicker, S, Turowski, B, Schebesch, K M, Brawanski, A, Wrede, Karsten, Sure, Ulrich, Schmidt, N O, Regelsberger, J, Westphal, M, Mielke, D, Rohde, V, Hosch, H, Moskopp, D, Joedicke, A, Hohaus, C, Meisel, H J, Wostrack, M, Meyer, B, Lehmberg, J, Musahl, C, Hopf, N, Winkler, G, Spetzger, U, Graewe, A, Meier, U, Hong, B, Nakamura, M, Krauss, J, Grote, A, Simon, M, Schramm, J, Kursumovic, A, Rath, S A, Marbacher, S, Fathi, A, Fandino, J, Familiari, P, Raco, A, Bijlenga, P, Schaller, K, Gruber, A, Wang, W T, Knosp, E, Hoffmann, K T, Boxhammer, E, Rüfenacht, Daniel, Boccardi, E, Piano, M, Niemelä, M, Nurminen, V, Lehecka, M, Hernesniemi, J, Burkhardt, J K, Bozinov, O, Regli, L, Shekhtman, O D, Eliava, S S, Kato, N, Irie, K, Nishimura, K, Kaku, S, Arakawa, H, Yuki, I, Ishibashi, T, Murayama, Y, Fiss, I, Kombos, T, Pedro, M T, König, R, Wirtz, R, Helthuis, J, van der Zwan, A, Cognard, C, Gawlitza, M, Wanke, Isabel, Fiedler, J, Surgical clinical sciences, University of Zurich, and Dengler, Julius
- Subjects
Aneurysm volume ,Adult ,Male ,medicine.medical_specialty ,animal structures ,Perianeurysmal edema ,Clinical Neurology ,Medizin ,610 Medicine & health ,Brain Edema ,Giant intracranial aneurysm ,Partially thrombosed aneurysm ,Vascular disorders ,Aged ,Female ,Humans ,Intracranial Aneurysm ,Magnetic Resonance Imaging ,Middle Aged ,Retrospective Studies ,Thrombosis ,Surgery ,Medicine (all) ,Neurology (clinical) ,Imaging data ,10180 Clinic for Neurosurgery ,Aneurysm ,medicine.artery ,Edema ,medicine ,10. No inequality ,medicine.diagnostic_test ,business.industry ,Research Support, Non-U.S. Gov't ,Magnetic resonance imaging ,medicine.disease ,2746 Surgery ,ddc:616.8 ,Giant Intracranial Aneurysm ,2728 Neurology (clinical) ,Middle cerebral artery ,Radiology ,Internal carotid artery ,medicine.symptom ,business ,Partial thrombosis - Abstract
OBJECT The underlying mechanisms causing intracranial perianeurysmal edema (PAE) are still poorly understood. Since PAE is most frequently observed in giant intracranial aneurysms (GIAs), the authors designed a study to examine the occurrence of PAE in relation to the location, size, and partial thrombosis (PT) of GIAs along with the clinical impact of PAE. METHODS Magnetic resonance imaging data for patients with a diagnosis of unruptured GIA from the international multicenter Giant Intracranial Aneurysm Registry were retrospectively analyzed with regard to location and size of the GIA, PAE volume, and the presence of PT. The occurrence of PAE was correlated to clinical findings. RESULTS Imaging data for 69 GIAs were eligible for inclusion in this study. Perianeurysmal edema was observed in 33.3% of all cases, with the highest frequency in GIAs of the middle cerebral artery (MCA; 68.8%) and the lowest frequency in GIAs of the cavernous internal carotid artery (ICA; 0.0%). Independent predictors of PAE formation were GIA volume (OR 1.13, p = 0.02) and the occurrence of PT (OR 9.84, p = 0.04). Giant intracranial aneurysm location did not predict PAE occurrence. Giant aneurysms with PAE were larger than GIAs without PAE (p < 0.01), and GIA volume correlated with PAE volume (rs = 0.51, p = 0.01). Perianeurysmal edema had no influence on the modified Rankin Scale score (p = 0.30 or the occurrence of aphasia (p = 0.61) or hemiparesis (p = 0.82). CONCLUSIONS Perianeurysmal edema was associated with GIA size and the presence of PT. As no PAE was observed in cavernous ICA aneurysms, even though they exerted mass effect on the brain and also displayed PT, the dura mater may serve as a barrier protecting the brain from PAE formation.
- Published
- 2015
117. Value of DSA in the diagnostic workup of pulsatile tinnitus
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Deuschl, Cornelius, Göricke, Sophia, Gramsch, Carolin, Özkan, Neriman, Lehnerdt, Götz Frederik, Kastrup, Oliver, Ringelstein, Adrian, Wanke, Isabel, Forsting, Michael, and Schlamann, Marc U.
- Subjects
Adult ,Male ,Databases, Factual ,Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Neurologie ,Medizin ,lcsh:Medicine ,Diagnosis, Differential ,Tinnitus ,ddc:6 ,Humans ,lcsh:Science ,Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Hals-Nasen-Ohrenheilkunde ,Aged ,Retrospective Studies ,Central Nervous System Vascular Malformations ,lcsh:R ,Angiography, Digital Subtraction ,Middle Aged ,Magnetic Resonance Imaging ,body regions ,Medizinische Fakultät » Universitätsklinikum Essen » Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie ,Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Neurochirurgie Wirbelsäulenchirurgie ,Female ,lcsh:Q ,ddc:600 ,Research Article - Abstract
Objectives: Pulsatile tinnitus (PT) is a rare complaint, but can be a symptom of life-threatening disease. It is often caused by vascular pathologies, e.g. dural arteriovenous fistula (dAVF), arteriovenous malformation (AVM) or vascularized tumors. The current diagnostic pathway includes clinical examination, cranial MRI and additional DSA. The aim of this study was to evaluate the diagnostic impact of DSA in the diagnostic workup of patients with PT in comparison to MRI alone. Methods: Retrospectively, 54 consecutive patients with pulsatile tinnitus were evaluated. All patients had a diagnostic workup including cranial MRI and DSA. MRI examinations were blinded to the results of DSA and retrospectively analyzed in consensus by two experienced neuroradiologists. The MR-examinations were evaluated for each performed sequence separately: time-of-flight-angiography, ce-MRA, T2, ce-T1-sequence and ce-T1-sequence with fat saturation. Results: 37 of the 54 patients revealed a pathology explaining PT on MRI, which was detected by the readers in 100% and proofed by means of DSA. 24 dAVF, four paraganglioma, two AVM and seven more pathologies were described. All patients without pathology on MRI did also not show any pathology in DSA. Conclusions: MR imaging is sufficient to exclude pathology in patients with pulsatile tinnitus. OA Förderung 2015
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- 2015
118. Brain arterio-venous malformations (BAVM) with dural arterial supply : effect of dural supply obliteration on headaches
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Agosti, R., Wanke, Isabel, and Rüfenacht, Daniel
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Medizin - Published
- 2015
119. Clinical outcome and pitfalls in the treatment of spinal dural arteriovenous fistulas
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Oezkan, Neriman, Keitschmann-Andermahr, Ilonka, Sandalcioglu, I. Erol, Goerike, Sophia, Wanke, Isabel, and Sure, Ulrich
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body regions ,ddc: 610 ,dural fistula ,spinal vascular fistula ,spinal vascular diseases ,610 Medical sciences ,Medicine - Abstract
Objective: The aim of our retrospective study is to demonstrate our experience in the treatment of spinal dural arteriovenous fistulas and to identify factors that influence the neurological outcome of our patients. Method: Between 2001 and 2013, a consecutive series of 32 patients diagnosed with[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
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- 2014
120. A novel, non-adhesive, precipitating liquid embolic implant with intrinsic radiopacity: feasibility and safety animal study
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Kulcsár, Zsolt, primary, Karol, Agnieszka, additional, Kronen, Peter W., additional, Svende, Pfundstein, additional, Klein, Karina, additional, Jordan, Olivier, additional, and Wanke, Isabel, additional
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- 2016
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121. Safety and effectiveness of large volume coils in the treatment of small aneurysms
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Kulcsár, Zsolt, primary, Wanke, Isabel, additional, Rüfenacht, Daniel, additional, Wetzel, Stephan G, additional, Göricke, Sophia, additional, Kolia, Kiriaki, additional, Quarfordt, Steven, additional, Calvert, Justin, additional, Hawk, Harris, additional, and Baxter, Blaise, additional
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- 2016
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122. The unruptured intracranial aneurysm treatment score : A multidis ciplinary consensus
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Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, Loch Macdonald, R., Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, and Loch Macdonald, R.
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- 2015
123. Posterior fossa arterio-venous malformations: current multimodal treatment strategies and results
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Stein, Klaus-Peter, Wanke, Isabel, Schlamann, Mark, Dammann, Philipp, Moldovan, Alexia, Sandalcioglu, I. Erol, and Sure, Ulrich
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body regions ,ddc: 610 ,posterior fossa ,arterio-venous malformation ,haemorrhage ,610 Medical sciences ,Medicine - Abstract
Objective: To determine the clinical presentation, the multimodal interdisciplinary treatment strategies and outcome of posterior fossa arterio-venous malformations (AVM). Method: Between 1998 and 2012, a total of 53 patients (mean age 43.8 years) with a posterior fossa AVM were treated either alone[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
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- 2013
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124. Endovaskuläre Aneurysmatherapie
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Wanke, Isabel, Forsting, Michael, and Rufenacht, D. A.
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Medizin - Published
- 2013
125. Clinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape
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Hirsch, Sven, Egger, Julian, Wanke, Isabel, Kulcsar, Zsolt, and Rüfenacht, Daniel
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Biomedical simulation ,Endovascular treatment ,Blood flow ,Intracranial aneurysms ,Thrombus ,Remodeling ,616: Innere Medizin und Krankheiten - Abstract
We present a clinical perspective, supported by biological findings, reflecting the potential of computational tools to understand and treat intracranial aneurysms. Thrombus formation and chronic inflammation are integral to disease progression, driven by blood flow energy. The interplay between flow energy, blood clotting and remodeling of the tissue is key to an enhanced disease understanding, to improve patient counseling and ultimately endovascular treatment planning. Current concepts suggest that blood governs wall remodeling by multiple biological steps. The process starts with flow induced thrombus adhesion (atherothrombosis) to the wall that secondarily leads to the release of biological mediators of inflammation entertaining destructive remodeling. Destructive wall remodeling jeopardizes the mechanical wall integrity with ensuing circumscribed softening and expansion of the aneurysm shape. The shape of an aneurysm is the visible result of these complex pathological processes and characterizes its disease status. Wall adherent thrombus formation, inflammatory reactions and the driving force of blood flow cause lumen shape changes. Here, shape irregularity is a distinctive sign of focal wall weakening. The integration of shape-analysis,vascular biology and phenotypical information will allow for personalized characterization of aneurysmal vascular disease and help to identify and establish shape as an image-based biomarker. Future translational efforts should aim at providing adequate IT tools and contributing to validation and disease understanding. Ensuing results will have a high likelihood to impact significantly on current clinical disease management.
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- 2013
126. Risk of recurrent stroke in patients with silent brain infarction in the PRoFESS Imaging Substudy
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Weber, Ralph, Weimar, Christian, Wanke, Isabel, Möller-Hartmann, Claudia, Gizewski, Elke R., Blatchford, Jon, Hermansson, Karin, Demchuk, Andrew M., Forsting, Michael, Sacco, Ralph L., Saver, Jeffrey L., Warach, Steven, Diener, Hans Christoph, and Diehl, Anke
- Subjects
Male ,Ticlopidine ,Vasodilator Agents ,Kaplan-Meier Estimate ,Benzoates ,Article ,Brain Ischemia ,Risk Factors ,Secondary Prevention ,Humans ,Telmisartan ,Aged ,Aspirin ,Cerebral Infarction ,Dipyridamole ,Middle Aged ,Magnetic Resonance Imaging ,Clopidogrel ,Stroke ,Treatment Outcome ,Intracranial Embolism ,Socioeconomic Factors ,Benzimidazoles ,Female ,Tomography, X-Ray Computed ,Angiotensin II Type 1 Receptor Blockers ,Platelet Aggregation Inhibitors - Abstract
Silent brain infarctions are associated with an increased risk of stroke in healthy individuals. Risk of recurrent stroke in patients with both symptomatic and silent brain infarction (SBI) has only been investigated in patients with cardioembolic stroke in the European Atrial Fibrillation Trial. We assessed whether patients with recent noncardioembolic stroke and SBI detected on MRI are at increased risk for recurrent stroke, other cardiovascular events, and mortality.The prevalence of SBI detected on MRI was assessed in 1014 patients enrolled in the imaging substudy of the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial. The primary outcome was first recurrence of stroke in patients with both symptomatic stroke and SBI in comparison with age- and sex-matched patients with stroke without SBI. Secondary outcomes were a combined vascular end point, other vascular events, and mortality. The 2 groups were compared using conditional logistic regression.Silent brain infarction was detected in 207 (20.4%) of the 1014 patients. Twenty-seven (13.0%) patients with SBI and 19 (9.2%) without SBI had a recurrent stroke (OR, 1.42; 95% CI, 0.79-2.56; P=0.24) during a mean follow-up of 2.5 years. Similarly, there was no statistically significant difference for all secondary outcome parameters between patients with SBI and matched patients without SBI.The presence of SBI in patients with recent mild noncardioembolic ischemic stroke could not be shown to be an independent risk factor for recurrent stroke, other vascular events, or a higher mortality rate.URL: http://clinicaltrials.gov. Unique identifier: NCT00153062.
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- 2012
127. Automatic histogram-based segmentation of white matter hyperintensities using 3D FLAIR images
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Lopes Simoes, Rita, Slump, Cornelis H., Mönninghoff, Christoph, Wanke, Isabel, Dlugaj, Martha, Weimar, Christian, van Ginneken, Bram, and Novak, Carol L.
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Ground truth ,EWI-21632 ,medicine.diagnostic_test ,business.industry ,Computer science ,Medizin ,IR-79875 ,METIS-285168 ,Magnetic resonance imaging ,Fluid-attenuated inversion recovery ,Hyperintensity ,Histogram ,medicine ,Computer vision ,Segmentation ,Artificial intelligence ,business - Abstract
White matter hyperintensities are known to play a role in the cognitive decline experienced by patients suffering from neurological diseases. Therefore, accurately detecting and monitoring these lesions is of importance. Automatic methods for segmenting white matter lesions typically use multimodal MRI data. Furthermore, many methods use a training set to perform a classication task or to determine necessary parameters. In this work, we describe and evaluate an unsupervised segmentation method that is based solely on the histogram of FLAIR images. It approximates the histogram by a mixture of three Gaussians in order to nd an appropriate threshold for white matter hyperintensities. We use a context-sensitive Expectation-Maximization method to determine the Gaussian mixture parameters. The segmentation is subsequently corrected for false positives using the knowledge of the location of typical FLAIR artifacts. A preliminary validation with the ground truth on 6 patients revealed a Similarity Index of 0.73 ± 0.10, indicating that the method is comparable to others in the literature which require multimodal MRI and/or a preliminary training step.
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- 2012
128. The management of arteriovenous malformations
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Sandalcioglu, Erol, Wanke, Isabel, Zappala, V., Forsting, Michael, and Sure, Ulrich
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Medizin - Published
- 2011
129. The unruptured intracranial aneurysm treatment score
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Etminan, Nima, primary, Brown, Robert D., additional, Beseoglu, Kerim, additional, Juvela, Seppo, additional, Raymond, Jean, additional, Morita, Akio, additional, Torner, James C., additional, Derdeyn, Colin P., additional, Raabe, Andreas, additional, Mocco, J., additional, Korja, Miikka, additional, Abdulazim, Amr, additional, Amin-Hanjani, Sepideh, additional, Al-Shahi Salman, Rustam, additional, Barrow, Daniel L., additional, Bederson, Joshua, additional, Bonafe, Alain, additional, Dumont, Aaron S., additional, Fiorella, David J., additional, Gruber, Andreas, additional, Hankey, Graeme J., additional, Hasan, David M., additional, Hoh, Brian L., additional, Jabbour, Pascal, additional, Kasuya, Hidetoshi, additional, Kelly, Michael E., additional, Kirkpatrick, Peter J., additional, Knuckey, Neville, additional, Koivisto, Timo, additional, Krings, Timo, additional, Lawton, Michael T., additional, Marotta, Thomas R., additional, Mayer, Stephan A., additional, Mee, Edward, additional, Pereira, Vitor Mendes, additional, Molyneux, Andrew, additional, Morgan, Michael K., additional, Mori, Kentaro, additional, Murayama, Yuichi, additional, Nagahiro, Shinji, additional, Nakayama, Naoki, additional, Niemelä, Mika, additional, Ogilvy, Christopher S., additional, Pierot, Laurent, additional, Rabinstein, Alejandro A., additional, Roos, Yvo B.W.E.M., additional, Rinne, Jaakko, additional, Rosenwasser, Robert H., additional, Ronkainen, Antti, additional, Schaller, Karl, additional, Seifert, Volker, additional, Solomon, Robert A., additional, Spears, Julian, additional, Steiger, Hans-Jakob, additional, Vergouwen, Mervyn D.I., additional, Wanke, Isabel, additional, Wermer, Marieke J.H., additional, Wong, George K.C., additional, Wong, John H., additional, Zipfel, Gregory J., additional, Connolly, E. Sander, additional, Steinmetz, Helmuth, additional, Lanzino, Giuseppe, additional, Pasqualin, Alberto, additional, Rüfenacht, Daniel, additional, Vajkoczy, Peter, additional, McDougall, Cameron, additional, Hänggi, Daniel, additional, LeRoux, Peter, additional, Rinkel, Gabriel J.E., additional, and Macdonald, R. Loch, additional
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- 2015
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130. A Pilot Study of the Intracranial Multilayer Flow Modulator as a New Disruptive Technology in the Treatment of Cerebral Aneurysms
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Sultan, Sherif, primary, Kavanagh, Edel P, additional, Alves, Antoine, additional, Wanke, Isabel, additional, Goericke, Sophia, additional, Ruefenacht, Daniel, additional, and Hynes, Niamh, additional
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- 2015
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131. Value of DSA in the Diagnostic Workup of Pulsatile Tinnitus
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Deuschl, Cornelius, primary, Göricke, Sophia, additional, Gramsch, Carolin, additional, Özkan, Neriman, additional, Lehnerdt, Götz, additional, Kastrup, Oliver, additional, Ringelstein, Adrian, additional, Wanke, Isabel, additional, Forsting, Michael, additional, and Schlamann, Marc, additional
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- 2015
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132. Developmental Venous Anomalies
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Forsting, Michael, primary and Wanke, Isabel, additional
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133. Intracranial Aneurysms
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Wanke, Isabel, primary, Dörfler, Arnd, additional, and Forsting, Michael, additional
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134. Modifiable Lifestyle Factors in Dementia: A Systematic Review of Longitudinal Observational Cohort Studies
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Di Marco, Luigi Yuri, primary, Marzo, Alberto, additional, Muñoz-Ruiz, Miguel, additional, Ikram, M. Arfan, additional, Kivipelto, Miia, additional, Ruefenacht, Daniel, additional, Venneri, Annalena, additional, Soininen, Hilkka, additional, Wanke, Isabel, additional, Ventikos, Yiannis A., additional, and Frangi, Alejandro F., additional
- Published
- 2014
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135. P3-204: ROLE OF HIPPOCAMPAL VOLUME IN IDENTIFYING MCI SUBTYPES: RESULTS OF A CASE-CONTROL STUDY
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Winkler, Angela, primary, Dlugaj, Martha, additional, Mönninghoff, Christoph, additional, Huppertz, Hans-Jürgen, additional, Wanke, Isabel, additional, Erbel, Raimund, additional, Jöckel, Karl-Heinz, additional, Gerwig, Marcus, additional, Moebus, Susanne, additional, and Weimar, Christian, additional
- Published
- 2014
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136. Pulssynchroner Tinnitus – radiologische Diagnostik und Therapie
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Wanke, Isabel, additional, Forsting, Michael, additional, and Rüfenacht, Daniel, additional
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- 2014
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137. Ruptured, fusiform, distal lenticulostriate aneurysm causing intraventricular haemorrhage in a patient with antiphospholipid-negative Sneddon's syndrome
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Killeen, Tim, primary, Wanke, Isabel, additional, Mangiardi, John, additional, and Cesnulis, Evaldas, additional
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- 2014
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138. Treatment of Wide-Necked Intracranial Aneurysms with a Self-Expanding Stent System: Initial Clinical Experience
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Wanke, Isabel, Doerfler, Arnd, Schoch, Beate, Stolke, Dietmar, and Forsting, Michael
- Subjects
Carotid Artery Diseases ,Interventional ,Angiography, Digital Subtraction ,Intracranial Aneurysm ,Middle Aged ,Subarachnoid Hemorrhage ,Combined Modality Therapy ,Embolization, Therapeutic ,Cerebral Angiography ,Recurrence ,Retreatment ,cardiovascular system ,Feasibility Studies ,Humans ,Cavernous Sinus ,Female ,Stents ,cardiovascular diseases ,Carotid Artery, Internal ,Magnetic Resonance Angiography ,Follow-Up Studies - Abstract
BACKGROUND AND PURPOSE: Currently available stents for intracranial use usually are balloon-expandable coronary stents that carry the risk of damaging a dysplastic segment of the artery, with potential vessel rupture. We assessed the technical feasibility and efficacy of the combined application of a flexible, self-expanding neurovascular stent and detachable coils in the management of wide-necked intracranial aneurysms in humans. METHODS: Four consecutive patients with a wide-necked intracranial aneurysm were treated with a combined approach that consisted of delivery of a flexible self-expanding neurovascular stent through a microcather to cover the neck of the aneurysm and subsequent filling of the aneurysm with coils through the stent interstices. The aneurysms were located at the internal carotid artery (n=2) and the basilar tip encroaching the P1 segment (n=2). Previous attempts with conventional endosaccular coil packing alone failed in all cases. RESULTS: Stent placement in the desired position with complete or nearly complete occlusion of the aneurysms was feasible in all patients. In one patient, aneurysm perforation with the microcatheter occurred and necessitated ventricular drainage, which led to a large parenchymal and intraventricular hemorrhage because of the strong anticoagulation regimen. Six-month follow-up demonstrated no focal neurologic sequelae in any of the patients, except slight memory dysfunction in the patient with bleeding. CONCLUSION: Preliminary data demonstrate that this extremely flexible stent is technically easy to deploy and can be easily and safely maneuvered through severely tortuous vessels, enabling the treatment of intracranial wide-necked aneurysms. The combination of endovascular reconstruction of the parent vessel with use of a self-expanding stent followed by coil embolization offers a promising therapeutic alternative for wide-necked aneurysms not amenable to coil embolization alone. Although immediate angiographic results are promising, long-term angiographic and clinical follow-up is essential to determine permanent vessel patency and aneurysm occlusion rate.
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- 2003
139. Tiefe Einsichten und schonende Eingriffe : Neuroradiologie
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Forsting, Michael and Wanke, Isabel
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Medizinische Fakultät » Universitätsklinikum Essen » Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie ,Medizin ,ddc:61 ,ddc:610 - Abstract
Der Neuroradiologe beschäftigt sich mit der Diagnostik und interventionellen Therapie von Erkrankungen des zentralen Nervensystems. Wie kaum ein anderes Fach profitierte die Neuroradiologie von den technischen Neuerungen in den letzten zehn Jahren.
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- 2003
140. LONGITUDINAL RELATIONSHIP OF COGNITIVE PERFORMANCE AND CHANGE IN BRAIN VOLUME
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Winkler, Angela, Jokisch, Martha, Mönninghoff, Christoph, Huppertz, Hans-Jürgen, Wanke, Isabel, Erbel, Raimund, Jöckel, Karl-Heinz, Gerwig, Marcus, Moebus, Susanne, and Weimar, Christian
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- 2016
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141. Treatment of complex neurovascular lesions: an interdisciplinary angio suite approach
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Dammann, Philipp, primary, Breyer, Tobias, additional, Wrede, Karsten H., additional, Stein, Klaus-Peter, additional, Wanke, Isabel, additional, Grams, Astrid E., additional, Gizewski, Elke R., additional, Schlamann, Marc, additional, Forsting, Michael, additional, Sandalcioglu, I. Erol, additional, and Sure, Ulrich, additional
- Published
- 2013
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142. A new-generation, low-permeability flow diverting device for treatment of saccular aneurysms
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Mallik, Ajit S., primary, Nuss, Katja, additional, Kronen, Peter W., additional, Klein, Karina, additional, Karol, Agnieszka, additional, von Rechenberg, Brigitte, additional, Rüfenacht, Daniel A., additional, Wanke, Isabel, additional, and Kulcsár, Zsolt, additional
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- 2013
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143. Brain herniations into arachnoid granulations: about 68 cases in 38 patients and review of the literature.
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Malekzadehlashkariani, Sonaz, Wanke, Isabel, Rüfenacht, Daniel, and San Millán, Diego
- Abstract
Introduction: Brain herniations (BH) into arachnoid granulations (AG) in dural venous sinuses and calvarium have rarely been reported in the literature. Methods: MRIs of 38 patients with BH into AG (BHAG) were retrospectively analyzed. Locations of BHAG, gyrus/lobe of the herniated brain, parenchymal abnormalities of the BH, and clinical and radiological conditions with raised intracranial pressure were recorded. Results: Sixty-eight BHAG were found, by order of frequency, in the occipital squama (OS), transverse sinus (TS), lateral lacuna of the superior sagittal sinus (LLSSS), and straight sinus (SS), with cerebellar tissue being the most frequently involved in BHAG (94.5 % of OS, 55 % of TS, 100 % SS BHAG). Multiple BHAG were found in 58 % of the patients (up to five per patient). Parenchymal signal and structural changes (SSCG) were observed in 46 % of BHAG (100 % were cerebellar). Three patients had pseudotumor cerebri (PTCS); one patient had only MRI signs of PTCS. Twenty-one percent of patients had intracranial conditions susceptible of increasing cerebrospinal fluid (CSF) pressure other than PTCS. Conclusions: BHAG occurred in the OS, TS, LLSSS, and the SS. SSCG of the herniated cerebellum were frequent and possibly result from tethering/strangulation in the AG. No symptoms could be clearly attributed to BHAG, though in three cases of PTCS, TS BHAG could have contributed to sustaining the raised CSF pressure. Various factors are probably involved in the development of BHAG including normal pia-arachnoid bridges between the brain surface and the AG, hydrodynamic constrains on the brain and AG, and, in some cases, increased intracranial pressure. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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144. P2-233: The role of hippocampal atrophy for the differentiation between MCI subtypes: Results of a case-control study
- Author
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Dlugaj, Martha, primary, Mönninghoff, Christoph, additional, Huppertz, Hans-Jürgen, additional, Wanke, Isabel, additional, Jokisch, Daniel, additional, Erbel, Raimund, additional, Jöckel, Karl-Heinz, additional, Moebus, Susanne, additional, Gerwig, Marcus, additional, and Weimar, Christian, additional
- Published
- 2012
- Full Text
- View/download PDF
145. Automatic histogram-based segmentation of white matter hyperintensities using 3D FLAIR images
- Author
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Simões, Rita, primary, Slump, Cornelis, additional, Moenninghoff, Christoph, additional, Wanke, Isabel, additional, Dlugaj, Martha, additional, and Weimar, Christian, additional
- Published
- 2012
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- View/download PDF
146. Abstract 43: Effect of Clazosentan on Clinical Outcome After Aneurysmal Subarachnoid Hemorrhage and Endovascular Coiling: Results of the CONSCIOUS-3 Study
- Author
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Macdonald, Robert L, primary, Higashida, Randall, additional, Keller, Emanuela, additional, Mayer, Stephan A, additional, Molyneux, Andrew J, additional, Raabe, Andreas, additional, Vajkoczy, Peter, additional, Wanke, Isabel, additional, Bach, Doris, additional, Frey, Aline, additional, Nowbakht, Pegah, additional, Roux, Sébastien, additional, and Kassell, Neal F, additional
- Published
- 2012
- Full Text
- View/download PDF
147. Predictive value of clot imaging in acute ischemic stroke: A systematic review of artificial intelligence and conventional studies
- Author
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Dumitriu LaGrange, Daniela, Hofmeister, Jeremy, Rosi, Andrea, Vargas, Maria Isabel, Wanke, Isabel, Machi, Paolo, and Lövblad, Karl-Olof
- Abstract
The neuroimaging signs of the clot in acute ischemic stroke are relevant for clot biology and its response to treatment. The diagnostic and predictive value of clot imaging is confirmed by conventional studies and emerges as a topic of interest for artificial intelligence (AI) developments. We performed a systematic review to evaluate the state of the art of AI in clot imaging, how far AI is from becoming clinically beneficial, and what are the perspectives to consider for further developments. In parallel, the review is examining the evidence brought by conventional studies concerning the relevance of clot imaging, from 2019 to August 2022. The automatic detection and segmentation of the clot are the most important advances towards AI implementation in the clinic. Predictive radiomics models require further exploration and methods optimization. Future AI approaches could consider conventional clot imaging characteristics and patient specific vascular features as variables for model development.
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- 2023
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148. Ruptur- und Behandlungsrisiko gegeneinander abwägen
- Author
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Lücking, Hannes, primary, Dörfler, Arnd, additional, and Wanke, Isabel, additional
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- 2011
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149. Clazosentan for patients with subarachnoid haemorrhage: lessons learned – Authors' reply
- Author
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Macdonald, R Loch, primary, Higashida, Randall T, additional, Keller, Emanuela, additional, Mayer, Stephan A, additional, Molyneux, Andy, additional, Raabe, Andreas, additional, Vajkoczy, Peter, additional, Wanke, Isabel, additional, Bach, Doris, additional, Frey, Aline, additional, Marr, Angelina, additional, Roux, Sébastien, additional, and Kassell, Neal, additional
- Published
- 2011
- Full Text
- View/download PDF
150. MELAS/SANDO overlap syndrome associated with POLG1 mutations
- Author
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Hansen, Niels, primary, Zwarg, Thomas, additional, Wanke, Isabel, additional, Zierz, Stephan, additional, Kastrup, Oliver, additional, and Deschauer, Marcus, additional
- Published
- 2011
- Full Text
- View/download PDF
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