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671 results on '"Wang, Xi-Cun"'

113. UV‐Light‐Irradiated Trifluoromethylation of Diheteroaryl Disulfides with CF3SO2Na.

Author

Cao, Bao‐Qian, Qiu, Yi‐Feng, Zhang, Xi, Zhu, Zheng‐He, Quan, Zheng‐Jun, and Wang, Xi‐Cun

Subjects
TRIFLUOROMETHYL compounds, DISULFIDES, SULFIDES, PHOTOCATALYSTS, KETONES
Abstract

A simple protocol for the UV light irradiated preparation of heteroaryl trifluoromethyl thioethers from disulfides and inexpensive, environmentally sodium triflinate (CF3SO2Na) has been developed. The features of simple and clean reaction conditions, in moderate to good yields, and broad substrate scope render this new approach synthetically attractive for the preparation of potentially pharmaceutically active compounds. A trifluoromethylation of diheteroaryl disulfides with CF3SO2Na to afford the trifluoromethyl thioethers derivatives. The conversion has good functional group compatibility, without external photocatalyst, generating the corresponding products in moderate to good yields under mild conditions, and the disulfide is fully utilized while constructing two S‐CF3 bonds. [ABSTRACT FROM AUTHOR]

Published
2019
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135. The palladium‐catalyzed C‐N cross‐coupling reaction of diheteroaryl disulfides with heterocyclic amines.

Author

Liu, Ming‐Xia, Zhang, Zhang, Quan, Zheng‐Jun, and Wang, Xi‐Cun

Subjects
PALLADIUM catalysts, COUPLING reactions (Chemistry), HETEROCYCLIC compounds, FUNCTIONAL groups, AMINATION, PYRIMIDINE derivatives
Abstract

The Pd‐catalyzed cross‐coupling reaction of 1, 2‐di(pyrimidin‐2‐yl) disulfides with heterocyclic amines including 2‐amino pyrimidines and 1,3,4‐thiadiazol‐2‐amines to deliver symmetrical C‐N coupling products in moderate to good yields is reported. This method provides an opportunity for synthesis of bioactive molecules and pharmaceutically interesting compounds containing heterocycle motifs. The reported protocol shows good functional group compatibility, and provides a new strategy for preparation of C2‐amination pyrimidine derivatives from heterocyclic disulfides. [ABSTRACT FROM AUTHOR]

Published
2018
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136. Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones.

Author

Wang, Tong-Lin, Liu, Xiao-Jun, Huo, Cong-De, Wang, Xi-Cun, and Quan, Zheng-Jun

Subjects
BASE catalysts, ANILINE, AROMATIC compound synthesis, THIONES, ALKYNE synthesis
Abstract

Here we show that the base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 is a powerful methodology to synthesize quinoline-2-thiones. This thio-lactamization uses inexpensive and versatile 2-(1-arylvinyl)anilines, which are easily available from the reaction of amines and alkynes. Compared to the known strategy in the literature, this method features the advantages like a short synthesis step and easily available starting materials. [ABSTRACT FROM AUTHOR]

Published
2018
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137. Direct Allylation of Aliphatic Primary Amines via Al(OTf)3‐Catalyzed One‐Pot Four‐Component Reaction.

Author

Wang, Tong‐Lin, Xu, Bin, Lu, Shi‐Hong, Wang, Xi‐Cun, and Quan, Zheng‐Jun

Abstract

Abstract: An amine‐methylchloroformate‐paraformaldehyde‐styrene condensation catalyzed by aluminium(III) triflate is described, leading to the synthesis of allylamides. This condensation provides an efficient method for the N‐carbonylation and N‐allylation of various aliphatic primary amines in good to excellent yields. [ABSTRACT FROM AUTHOR]

Published
2017
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