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Taking paddy as the research object,the integrated temperature and humidity sensors was used to carry out monitoring at different condensation prone locations by simulation of the actual granary.The temperature and relative humidity of different positions of grain stack from winter to summer were measured.Then the cloud map of the temperature field and humidity field of the paddy pile were drawn using Matrix Laboratory simulation software (abbreviated as MATLAB) to analyze the distribution of temperature and humidity fields of paddy.Based on the model of grain equilibrium absolute humidity and dew point temperature (CAE model),the different states (equilibrium state,saturation state,adsorption state or desorption state) of the dangerous point of rice pile were calculated,and the change rules were explored.The results of this paper will provide a theoretical basis for reducing grain storage loss and realizing grain storage safety.

The distribution of Mg isotopes in minerals is becoming increasingly relevant in Earth science. Usually, they are determined by dissolving mineral concentrates and, after purifying Mg with ion exchange resins, analysing the resulting solutions by TIMS or, most often, MC‐ICP‐MS. When applied to individual minerals, these methods are slow and prone to contamination from impurities in the concentrates, inconveniences that may be avoided using spot analysis techniques such as LA‐MC‐ICP‐MS or SIMS, albeit at the price of a large instrumental mass fractionation (IMF) and isobaric interferences, most prominent in the former. Here, we studied the potential of the multi‐collector SHRIMP II ion microprobe for measuring Mg isotopes in Fe‐Mg silicates and oxides. We found that, when corrected for the divergence of the Mg ion paths within the sample chamber caused by the Earth's magnetic field, the SHRIMP's IMF overwhelmingly depends on the mineral species, and the effects of variable chemical composition are negligible. We propose that the IMF is caused by the force constant difference, ∆F, between "hard" and "soft" bonds linking the ions of the studied element to the mineral lattice. Given that ∆F is a constant for each mineral species, we calculated IMF‐correction factors for the most common Mg‐bearing minerals. The thus‐calculated correction factors permit the analysis in the same session, and with reasonable accuracy (within ~ 0.3‰ of the δ26Mg determined by SN‐MC‐ICP‐MS analyses of concentrates), of samples from different mineral species, facilitating the application of Mg isotopes to terrestrial studies. [ABSTRACT FROM AUTHOR]

Minimally invasive thermal therapy is a successful alternative treatment to surgery in solid tumors with high complete ablation rates, however, tumor recurrence remains a concern. Central memory CD8+ T cells (TCM) play important roles in protection from chronic infection and cancer. Here we find, by single-cell RNA analysis of human breast cancer samples, that although the memory phenotype of peripheral CD8+ T cells increases slightly after microwave ablation (MWA), the metabolism of peripheral CD8+ T cells remains unfavorable for memory phenotype. In mouse models, glycolysis inhibition by 2-deoxy-D-glucose (2DG) in combination with MWA results in long-term anti-tumor effect via enhancing differentiation of tumor-specific CD44hiCD62L+CD8+ TCM cells. Enhancement of CD8+ TCM cell differentiation determined by Stat-1, is dependent on the tumor-draining lymph nodes (TDLN) but takes place in peripheral blood, with metabolic remodeling of CD8+ T cells lasting the entire course of the the combination therapy. Importantly, in-vitro glycolysis inhibition in peripheral CD8+ T cells of patients with breast or liver tumors having been treated with MWA thrice leads to their differentiation into CD8+ TCM cells. Our work thus offers a potential strategy to avoid tumor recurrence following MWA therapy and lays down the proof-of-principle for future clinical trials. Central memory CD8+ T cells (Tcm) are important for lasting anti-tumour immunity and their differentiation is determined by underpinning transcriptional and metabolic regulation. Authors here show that although microwave ablation (MWA) cancer therapy induces T cells to acquire some of the gene expression features of Tcms, but the full metabolic remodeling required for functionality is only achieved if glycolysis is inhibited simultaneously. [ABSTRACT FROM AUTHOR]

Nuclear transport of immune receptors, signal transducers, and transcription factors is an essential regulatory mechanism for immune activation. Whether and how this process is regulated at the level of the nuclear pore complex (NPC) remains unclear. Here, we report that CPR5, which plays a key inhibitory role in effector-triggered immunity (ETI) and programmed cell death (PCD) in plants, is a novel transmembrane nucleoporin. CPR5 associates with anchors of the NPC selective barrier to constrain nuclear access of signaling cargos and sequesters cyclin-dependent kinase inhibitors (CKIs) involved in ETI signal transduction. Upon activation by immunoreceptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for ETI signaling and reconfigures the selective barrier to allow significant influx of nuclear signaling cargos through the NPC. Consequently, these coordinated NPC actions result in simultaneous activation of diverse stress-related signaling pathways and constitute an essential regulatory mechanism specific for ETI/PCD induction.