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103. The pedunculopontine region and breathing in Parkinson’s disease

Author

Hyam, Jonathan A., Wang, Shouyan, Roy, Holly, Moosavi, Shakeeb H., Martin, Sean C., Brittain, John Stuart, Coyne, Terry, Silburn, Peter, Aziz, Tipu Z., and Green, Alexander L.

Abstract

Objective. Respiratory abnormalities such as upper airway obstruction are common in Parkinson's disease (PD) and are an important cause of mortality and morbidity. We tested the effect of pedunculopontine region (PPNr) stimulation on respiratory maneuvers in human participants with PD, and separately recorded PPNr neural activity reflected in the local field potential (LFP) during these maneuvers. Methods. Nine patients with deep brain stimulation electrodes in PPNr, and seven in globus pallidus interna (GPi) were studied during trials of maximal inspiration followed by forced expiration with stimulation OFF and ON. Local field potentials (LFPs) were recorded in the unstimulated condition. Results. PEFR increased from 6.41 ± 0.63 L/sec in the OFF stimulation state to 7.5 L ± 0.65 L/sec in the ON stimulation state (z = −2.666, df = 8, P = 0.024). Percentage improvement in PEFR was strongly correlated with proximity of the stimulated electrode contact to the mesencephalic locomotor region in the rostral PPN (r = 0.814, n = 9, P = 0.008). Mean PPNr LFP power increased within the alpha band (7–11 Hz) during forced respiratory maneuvers (1.63 ± 0.16 μV2/Hz) compared to resting breathing (0.77 ± 0.16 μV2/Hz; z = −2.197, df = 6, P = 0.028). No changes in alpha activity or spirometric indices were seen with GPi recording or stimulation. Percentage improvement in PEFR was strongly positively correlated with increase in alpha power (r = 0.653, n = 14 (7 PPNr patients recorded bilaterally), P = 0.0096). Interpretation. PPNr stimulation in PD improves indices of upper airway function. Increased alpha‐band activity is seen within the PPNr during forced respiratory maneuvers. Our findings suggest a link between the PPNr and respiratory performance in PD.

Published
2019

109. Dynamic changes in rhythmic and arrhythmic neural signatures in the subthalamic nucleus induced by anaesthesia and intubation

Author

Huang, Yongzhi, primary, Hu, Kejia, additional, Green, Alexander L., additional, Ma, Xin, additional, Gillies, Martin J., additional, Wang, Shouyan, additional, Fitzgerald, James J., additional, Pan, Yixin, additional, Martin, Sean, additional, Huang, Peng, additional, Zhan, Shikun, additional, Li, Dianyou, additional, Tan, Huiling, additional, Aziz, Tipu Z., additional, and Sun, Bomin, additional

Published
2019
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110. Decoding voluntary movements and postural tremor based on thalamic LFPs as a basis for closed-loop stimulation for essential tremor

Author

Tan, Huiling, primary, Debarros, Jean, additional, He, Shenghong, additional, Pogosyan, Alek, additional, Aziz, Tipu Z., additional, Huang, Yongzhi, additional, Wang, Shouyan, additional, Timmermann, Lars, additional, Visser-Vandewalle, Veerle, additional, Pedrosa, David J., additional, Green, Alexander L., additional, and Brown, Peter, additional

Published
2019
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113. The pedunculopontine region and breathing in Parkinson's disease

Author

Hyam, Jonathan A., primary, Wang, Shouyan, additional, Roy, Holly, additional, Moosavi, Shakeeb H., additional, Martin, Sean C., additional, Brittain, John Stuart, additional, Coyne, Terry, additional, Silburn, Peter, additional, Aziz, Tipu Z., additional, and Green, Alexander L., additional

Published
2019
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119. Functional dynamics of thalamic local field potentials correlate with modulation of neuropathic pain.

Author

Luo, Huichun, Huang, Yongzhi, Xiao, Xiao, Dai, Wenjing, Nie, Yingnan, Geng, Xinyi, Green, Alexander L., Aziz, Tipu Z., and Wang, Shouyan

Subjects
DEEP brain stimulation, ANALGESIA, PAIN
Abstract

Understanding the functional dynamics of neural oscillations in the sensory thalamus is essential for elucidating the perception and modulation of neuropathic pain. Local field potentials were recorded from the sensory thalamus of twelve neuropathic pain patients. Single and combinational neural states were defined by the activity state of a single or paired oscillations. Relationships between the duration or occurrence rate of neural state and pre‐operative pain level or pain relief induced by deep brain stimulation were evaluated. Results showed that the occurrence rate of the single neural state of low‐beta oscillation was significantly correlated with pain relief. The duration and occurrence rate of combinational neural states of the paired low‐beta with delta, theta, alpha, high‐beta or low‐gamma oscillations were more significantly correlated with pain relief than the single neural states. Moreover, these significant combinational neural states formed a local oscillatory network with low‐beta oscillation as a key node. The results also showed correlations between measures of combinational neural states and subjective pain level as well. The duration of combinational neural states of paired alpha with delta or theta oscillations and the occurrence rate of neural states of the paired delta with low‐beta or low‐gamma oscillations were significantly correlated with pre‐operative pain level. In conclusion, this study revealed that the integration of oscillations and the functional dynamics of neural states were differentially involved in modulation and perception of neuropathic pain. The functional dynamics could be biomarkers for developing neural state‐dependent deep brain stimulation for neuropathic pain. [ABSTRACT FROM AUTHOR]

Published
2020
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120. A super-enhancer maintains homeostatic expression of Regnase-1

Author

Yang, Riyun, primary, Wu, Yuanyuan, additional, Ming, Yue, additional, Xu, Yuanpei, additional, Wang, Shouyan, additional, Shen, Jianbo, additional, Wang, Chenlu, additional, Chen, Xia, additional, Wang, Yongming, additional, Mao, Renfang, additional, and Fan, Yihui, additional

Published
2018
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133. A simulation program on change trend of pollutant concentration under water pollution accidents and its application in Heshangshan drinking water source area.

Author

Wang, Shouyan, Jiang, Guihong, Ding, Xiaowen, and Huang, Guohe

Subjects
*DRINKING water, *WATER management, *WATER pollution, *POLLUTANTS, *PUBLIC health, *SIMULATION software
Abstract

With the rapid development of the economy in recent years, water pollution accidents have occurred frequently, and accidents that have occurred in drinking water source areas in particular have seriously affected public health and social safety. The objective of this study is to develop a program to predict the diffusion and migration processes of pollutants after water pollution accidents and apply it to the Heshangshan drinking water source area. Taking Cd as a typical pollutant, the results indicated that Cd concentrations at the water intake reached a maximum value of 1.2490 × 10 4 mg/L at 14.08 min after a hypothetical accident, and the time when the area lost the function of drinking water supply was from 8.35 min to 24.23 min after the accident. Regarding the drinking water source area, the Cd concentration exceeded the related standard during the period from 7.29 min to 41.47 min after the accident, which indicated that it was polluted seriously by the accident for that duration. Moreover, the pollutant entered into the study area at 7.00 min after the accident and had passed through at 45.63 min after the accident, which demonstrated that emergency measures should be taken for this duration. The developed simulation program could simulate the spatial distribution and temporal change of pollution, calculate maximum concentration of pollutants, present pollution scope and time, and forecast diffusion and transport processes. This study will give relative researchers and managers a reference and tool for pollutant migration and water resources management after water pollution accidents. [ABSTRACT FROM AUTHOR]

Published
2017
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134. Sparsity Level in a Non-negative Matrix Factorization Based Speech Strategy in Cochlear Implants

Author

Hongmei, Hu, Mohammadiha, Nasser, Taghia, Jalil, Leijon, Arne, Lutman, Mark E, and Wang, Shouyan

Subjects
cochlear implants, sparse coding, objective measurements, speech perception threshold, Non-negative matrix factorization, Electrical Engineering, Electronic Engineering, Information Engineering, Elektroteknik och elektronik
Abstract

Non-negative matrix factorization (NMF) has increasinglybeen used as a tool in signal processing in the last years, butit has not been used in the cochlear implants (CIs). Toimprove the performance of CIs in noisy environments, anovel sparse strategy is proposed by applying NMF onenvelops of 22 channels. In the new algorithm, the noisyspeech is first transferred to the time-frequency domain viaa 22- channel filter bank and the envelope in each frequencychannel is extracted; secondly, NMF is applied to theenvelope matrix (envelopegram); finally, the sparsitycondition is applied to the coefficient matrix to get moresparse representation. Speech reception threshold (SRT)subjective experiment was performed in combination withfive objective measurements in order to choose the properparameters for the sparse NMF model. QC 20121120

Published
2012
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