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416 results on '"Wang, Kaiping"'

107. A fabrication process for flexible single-crystal perovskite devices

Author

Lei, Yusheng, primary, Chen, Yimu, additional, Zhang, Ruiqi, additional, Li, Yuheng, additional, Yan, Qizhang, additional, Lee, Seunghyun, additional, Yu, Yugang, additional, Tsai, Hsinhan, additional, Choi, Woojin, additional, Wang, Kaiping, additional, Luo, Yanqi, additional, Gu, Yue, additional, Zheng, Xinran, additional, Wang, Chunfeng, additional, Wang, Chonghe, additional, Hu, Hongjie, additional, Li, Yang, additional, Qi, Baiyan, additional, Lin, Muyang, additional, Zhang, Zhuorui, additional, Dayeh, Shadi A., additional, Pharr, Matt, additional, Fenning, David P., additional, Lo, Yu-Hwa, additional, Luo, Jian, additional, Yang, Kesong, additional, Yoo, Jinkyoung, additional, Nie, Wanyi, additional, and Xu, Sheng, additional

Published
2020
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118. Sparking innovation: exploring the dual-engine effect of idea generation and conversion enabled by open innovation communities.

Author

Chu, Ying, Qi, Guijie, Wang, Kaiping, and Wang, Huiying

Subjects
*OPEN innovation, *SENTIMENT analysis, *TEXT mining, *INTELLECTUAL freedom, *PRODUCT improvement, *TECHNOLOGICAL innovations
Abstract

Open innovation communities (OICs) help firms gather ideas and access external resources for innovation, but the mechanisms and quantitative impacts of OICs on product innovation are underexplored. This study examines how OIC-driven innovation affects market performance, specifically word-of-mouth, for new products. Using the innovation value chain framework, this paper conceptualises two OIC-enabled innovation phases: idea generation (gathering ideas) and idea conversion (applying ideas to product development). Based on dynamic capability theory, we hypothesise that idea generation outputs enhance enterprise sensing capability, and idea conversion outputs enhance enterprise seising capability, contributing to competitive advantage through improved product word-of-mouth. Focusing on Xiaomi's MIUI system, we quantify each phase's impact on feature word-of-mouth post-launch using text mining techniques such as LDA topic clustering and sentiment analysis on community ideas and XiaomiStore reviews. Employing econometric methods, we empirically examine how outputs from idea generation and conversion stages affect feature word-of-mouth. Our findings highlight significant effects from both stages, with idea conversion serving as a partial mediator between idea generation and subsequent word-of-mouth. Pre-conversion ‘likes’ enhance the impact of both stages, while ‘comments’ show diminishing returns. This research provides insights into optimising OIC management and contributes to the existing literature. [ABSTRACT FROM AUTHOR]

Published
2024
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126. NIR-II imaging-guided diagnosis and evaluation of the therapeutic effect on acute alcoholic liver injury viaa nanoprobeElectronic supplementary information (ESI) available: Materials and instruments, structural characterization data, bioimaging procedures and some other auxiliary pictures. See DOI: 10.1039/d2ay00279e

Author

Nie, Gang, Zhou, Yinxing, Song, Mengzi, Xu, Jingya, Cui, Zheng, Feng, Yangzhen, Wang, Huiling, Chen, Dugang, Zhang, Yu, and Wang, Kaiping

Abstract

Acute alcoholic liver injury (AALI) is hard to diagnose on account of no obvious clinical symptoms, and thereby it easily develops into serious liver diseases and threatens people's health. However, traditional methods for detecting AALI are far from satisfactory due to the low sensitivity, invasiveness and non-visualization, and the development of new techniques is in urgent demand. Near-infrared (NIR)-II fluorescence imaging has been widely studied in biochemistry and biomedicine. As the blood flow velocity of the liver is closely related to the progression of AALI, herein, a NIR-II fluorescent nanoprobe, NTPB-NPs, was applied to diagnose AALI by monitoring the fluorescence intensity changes in the liver caused by the variations of the blood flow velocity. More importantly, when medication was applied to alleviate the liver injury of AALI mice, NTPB-NPs could also track the therapeutic effect in situ. In this study, the relationship between hepatic vascular velocity and the progression of AALI was confirmed with NTPB-NPs viaNIR-II imaging. To the best of our knowledge, this is the first time that a NIR-II fluorescence imaging technique has been used to diagnose AALI mice and evaluate the therapeutic effect on AALI mice. This study may also provide a potential NIR-II imaging agent for clinical research to improve the management of liver injury related diseases.

Published
2022
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128. Dendrobium officinale Polysaccharide Protected CCl4-Induced Liver Fibrosis Through Intestinal Homeostasis and the LPS-TLR4-NF-κB Signaling Pathway.

Author

Wang, Kaiping, Yang, Xiawen, Wu, Zhijing, Wang, Hongjing, Li, Qiang, Mei, Hao, You, Ruxu, and Zhang, Yu

Subjects
DENDROBIUM, BCL-2 proteins, FIBROSIS, OCCLUDINS, LIVER, BAX protein, TIGHT junctions
Abstract

We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and lessened intestinal mucosal damage. Western blot and PCR results showed that DOP maintained intestinal balance by upregulating the expression of tight junction proteins such as occludin, claudin-1, ZO-1, and Bcl-2 proteins while downregulating the expression of Bax and caspase-3 proteins in the intestine. The transepithelial electrical resistance (TEER) value of the LPS-induced Caco-2 monolayer cell model was increased after DOP administration. These illustrated that DOP can protect the intestinal mucosal barrier function. DOP also inhibited activation of the LPS-TLR4-NF-κB signaling pathway to reduce the contents of inflammatory factors TGF-β and TNF-α, increased the expression of anti-inflammatory factor IL-10, and significantly decreased α-SMA and collagen I expression. These results indicated that DOP maintained intestinal homeostasis by enhancing tight junctions between intestinal cells and reducing apoptosis, thereby inhibiting activation of the LPS-TLR4-NF-κB signaling pathway to protect against liver fibrosis. [ABSTRACT FROM AUTHOR]

Published
2020
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129. Corrigendum to “Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro” [Int. J. Biol. Macromol. 111 (May 2018) 1133–1139]

Author

Cao, Peng, primary, Sun, Jinlu, additional, Sullivan, Mitchell A., additional, Huang, Xiao, additional, Wang, Hanxiang, additional, Zhang, Yu, additional, Wang, Na, additional, and Wang, Kaiping, additional

Published
2018
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134. Retraction notice to “Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating Sirt1-AMPK pathway” [JNB 43 (2017) 88–97]

Author

Wang, Kaiping, primary, Tang, Zhuohong, additional, Wang, Jinglin, additional, Cao, Peng, additional, Li, Qiang, additional, Shui, Weizhi, additional, Wang, Hongjing, additional, Zheng, Ziming, additional, and Zhang, Yu, additional

Published
2017
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140. Preparation and UV Photoelectric Properties of Aligned ZnO–TiO2and TiO2–ZnO Core–Shell Structured Heterojunction Nanotubes

Author

Zhou, Ming, Wu, Bozhi, Zhang, Xueting, Cao, Shiquan, Ma, Pengpeng, Wang, Kaiping, Fan, Zhengpeng, and Su, Maogen

Abstract

Large-area horizontal-aligned ZnO nanotubes (ZNTs), TiO2nanotubes (TNTs), TiO2–ZnO core–shell nanotubes (TZNTs) and ZnO-TiO2core–shell nanotubes (ZTNTs) were successfully synthesized by electrospinning combined with pulsed-laser deposition. The morphology, structure, and composition of the samples were characterized by scanning electron microscopy, high-resolution transmission electron microscopy, and Raman spectroscopy. The photoluminescence (PL) spectra of these samples indicate that the addition of a TiO2layer greatly decreases the recombination of photogenerated carriers in the heterojunction nanotubes. The photodetectors (PDs) were fabricated by assembling horizontally ordered nanotubes on the gold interdigital electrode, and their ultraviolet (UV) detection performances were compared. The test results at room temperature show that the PD with aligned ZTNTs have the best UV response and a short response recovery time. In addition, the performance of ZTNT PDs and TZNT PDs are further improved under heating. The photo/dark current ratio, responsivity (Rλ), detectivity (D*), and external quantum efficiency (EQE) of ZTNTs increased to 388, 450 uA·W–1, 1.1 × 1010cm·Hz1/2·W–1, and 0.15%, respectively, under the condition of 365 nm UV radiation with a power density of 4.9 mW·cm–2and a 1 V bias at 90 °C. The UV response mechanism and structural superiority of the horizontally ordered coaxial heteronanotube were also discussed. In addition, this work provides an important method for the design of other ordered nanomaterials and structures, which have a wide range of applications in the fields of sensors, transistors, transparent flexible electrodes, and other multifunctional devices.

Published
2020
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141. Synthesis, purification, and anticancer effect of magnetic Fe3O4-loaded poly (lactic-co-glycolic) nanoparticles of the natural drug tetrandrine.

Author

Wang, Kaiping, Hu, Huiping, Zhang, Qian, Zhang, Yu, and Shi, Chen

Subjects
*MAGNETIC nanoparticles, *MAGNETIC materials, *SURFACE charges, *NANOPARTICLES, *ANTINEOPLASTIC agents
Abstract

Here, we have successfully synthesised and purified multifunctional PLGA-based nanoparticles by the co-encapsulation of an anticancer drug (tetrandrine) and a magnetic material (Fe3O4). The obtained Tet-Fe3O4-PLGA NPs had a uniform spherical shape with a particle size of approximately 199 nm and a negative surface charge of –18.0 mV, displaying a high encapsulation efficiency. Furthermore, TEM studies provided representative images of the purification process of the magnetic nanoparticles with MACS® technology. The MFM and VSM results indicated that both the Fe3O4 NPs and Tet-Fe3O4-PLGA NPs were superparamagnetic. The DSC spectrum demonstrated that Tet was successfully encapsulated within the PLGA-based nanoparticles. Significantly, the release studies revealed NPs had a relatively slower release rate than free Tet after 8 h's initial burst release, which had decreased from 98% to 65% after 24 h. In vitro cellular studies revealed that NPs could effectively penetrate into A549 cells and A549 multicellular spheroids to exert cytotoxicity, displaying a significantly high anti-proliferation effect. Moreover, western blot demonstrated that the co-loaded NPs had a higher anticancer activity by injuring lysosomes to activate the mitochondria pathway and induce A549 cell apoptosis. The magnetic characteristics and high anticancer activity support the use of Tet/Fe3O4 co-loaded PLGA-based nanoparticles as a promising strategy in the treatment of lung cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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142. Direct Diazoarylation of [1.1.1]Propellane with Arenediazonium Salts: A Modular Assembly of Arylated Diazo Bicyclo[1.1.1]pentanes

Author

Nan, Hailing, Cheng, Beiyi, Zhang, Duo, Wang, Kaiping, Wang, Shuli, Xu, Bingxin, Zhang, Shuwei, König, Burkhard, and Zhang, Guodong

Abstract

A mild and concise diazoarylation of [1.1.1]propellane is described, which provides a modular approach to arylated diazo bicyclopentanes (BCPs). This reaction proceeds smoothly under basic conditions without requiring other additives or catalysts. The substrate scope shows that various electron-withdrawing and electron-donating groups are tolerated, and the subsequent modifications provide a novel avenue for assembling arylamino-BCP analogs.

Published
2024
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143. Photocatalyzed 1,3-Bromodifluoroallylation of [1.1.1]Propellane with α-Trifluoromethylalkenes and KBr Salts

Author

Wang, Kaiping, Cheng, Beiyi, König, Burkhard, Zhang, Duo, Xu, Bingxin, Wang, Shuli, and Zhang, Guodong

Abstract

Herein we unveil a visible-light-driven transition-metal-free 1,3-bromodifluoroallylation of [1.1.1]propellane. This reactivity is harnessed through organophotocatalysis, providing practical synthetic pathways to 1-brominated-3-gem-difluoroallylic bicyclo[1.1.1]pentane derivatives, particularly derived from readily available α-trifluoromethylalkenes and inexpensive KBr salts utilized as precursors for bromine radicals. Mechanistic investigations reveal that bromide anions quench the excited state of the photocatalyst, leading to the formation of bromine radicals, which react in a strain-release radical addition process rather than hydrogen atom abstraction with [1.1.1]propellane.

Published
2024
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144. Two-dimensional inverse problem of fire location in the closed goaf of coal mine based on optical fiber sensors.

Author

Liu, Yujiao, Chen, Lu, Wang, Kaiping, Liu, Zeyi, Zhang, Yao, Shi, Lianzeng, Gao, Ke, and Yang, Zemiao

Subjects
*OPTICAL fiber detectors, *COAL mining, *FIRE detectors, *INVERSE problems, *GREEN'S functions, *COAL mining accidents, *SPONTANEOUS combustion, *TEMPERATURE distribution
Abstract

Monitoring the temperature to determine the fire source locations is essential for controlling the spontaneous combustion in the goaf. Optical fiber sensors are employed to measure the temperature distribution in the goaf. However, due to changes in the geological conditions and the influence of the falling rocks in the goaf, only sensors on the upper side of the uncompacted goaf, due to inclination and coal pillar, may remain. Unilateral sensors are located on the upper side of the goaf, while fire occurs in the center. To investigate the issue with linear unilateral sensors, a two-dimensional inverse method has been developed to determine the location of fire sources by considering heat transfer after a fire inside the goaf. The equations were theoretically solved using Green's function method to obtain the internal temperature distribution of the physical model of the goaf. Sensitivity analysis identified the most crucial parameters in the process of spontaneous heating at different temperature. The fire source location can be determined using a loop method based on the model calculations. We considered a case to validate the model. Accurately identifying the fire source location in the goaf using the unilateral sensors has an essential theoretical and practical significance for fire prevention and fighting. [ABSTRACT FROM AUTHOR]

Published
2024
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150. Comparison and the lipid-lowering ability evaluation method discussion of Dendrobium officinale polysaccharides from different origins based on principal component analysis.

Author

Wang, Kaiping, Song, Mengzi, Mu, Xu, Wu, Zhijing, Wu, Niuniu, and Zhang, Yu

Subjects
*PRINCIPAL components analysis, *POLYSACCHARIDES, *MONOSACCHARIDES, *DENDROBIUM, *EVALUATION methodology
Abstract

As typical acetylated glucomannans, Dendrobium officinale polysaccharides (DOPs) from different origins differ in their structural characteristics and some of their physicochemical properties. To rapidly select D. officinale plants, we systematically investigate the differences among DOPs from different origins and analyzed the structural characteristics, such as the degree of acetylation and monosaccharide composition; the physicochemical properties, such as solubility, water absorption and apparent viscosity; and the lipid-lowering activity of the obtained DOPs. Principal component analysis (PCA), a method for analyzing multiple variables, was used to analyze the relationship between the physicochemical and structural properties, and lipid-lowering activity. It was found that the structural and physicochemical characteristics had significant effects on lipid-lowering activity, and DOPs with a high degree of acetylation, high apparent viscosity and large D-mannose-to- d -glucose ratio were associated with greater lipid-lowering activity. Therefore, this study provides a reference for the selection and application of D. officinale. [ABSTRACT FROM AUTHOR]

Published
2023
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