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In this paper, the content of rockery protection was discussed through the analysis of a series of documents such as the convention, declaration, and regulations concerning heritage protection in accordance with the principles of authenticity and integrity. Through the analysis of the influence factors of the rockery and its environment, it is proposed that the rockery protection should strengthen environmental protection on the basis of the protection of the body of a rockery. From the perspectives of structure, skill, materials and function, the contents of the rockery protection and the human settlement environment where the rockery is located, the external environment and internal environment of the rockery space were analyzed, and the contents of the rockery protection were preliminarily proposed. [ABSTRACT FROM AUTHOR]

Abstract Purpose To report novel BEST1 variants in six Chinese families with bestrophinopathies of two different inheritance modes and analyze the intrafamilial phenotypic diversity. Method A total of 25 participants including 13 patients and 12 healthy family members from 6 Chinese families with bestrophinopathies were available for genetic and clinical analysis. All of the patients were subjected to comprehensive ophthalmic evaluations and exome sequencing was performed on the probands to detect the causative variants. The pathogenicity of gene variants was predicted using silico analysis and evaluated according to ACMG guidelines. All (likely) pathogenic variants were determined by Sanger sequencing and co‐segregation analyses were performed on available family members. The relevant original literature previously reported was retrieved to explore the relationship between BEST1‐related gene variants and clinical features. Results In the 6 families, 3 families (10 patients) were assigned as autosomal dominant bestrophinopathies (VMD) and 3 families (3 patients) were assigned as Autosomal recessive Bestrophinopathies (ARB). A total of 9 variants on the BEST1 gene were identified, containing 7 missense variants, 1 nonsense variant, and 1 frameshift variant, respectively, of which 3 variants c.88A > G (p.Lys30Glu), c.764G > A (p.Arg255Gln) and c.233dupT (p.Ser79Phefs*153) were novel variants. Three families with ARB were detected with heterozygous variants on the BEST1 gene.2 families (8 patients) with BVMD showed markedly irregular dominant inheritance, and the severity of macular lesions varies greatly among individuals of the same family. Among them, the probands showed typical vitelliform lesions in the macula, while the other six patients had no visible signs of the disease by fundus photography (ophthalmoscopy) and minor lesions could be detected on OCT in two patients, the continuity of the ellipsoidal band was interrupted with the chimeric band. The phenotypes of the patients in the three ARB families ranged from typical/atypical vitelliform lesions to extensive extramacular deposits (peripheral spots). Conclusion This study provided evidence that the phenotype of BVMD manifested irregular dominant inheritance, with patients carrying a pathogenic heterozygous variant of BEST1 to develop obvious intrafamilial phenotypic diversity, and the patients who harbor two pathogenic alleles showed recessive inheritance bestrophinopathies with distinct phenotypic diversity. Our study also emphasized the importance of comprehensive genetic analysis in patients with bestrophinopathies, and in such challenging families with distinct intrafamilial phenotypic diversity, it shall provide novel insights into phenotypic assessments of bestrophinopathies, and contribute to better diagnosis, prognosis, and treatment for these patients.

Query completion approaches assist searchers in formulating queries with few keystrokes when using an information retrieval system to address their information needs, which help users benefit from avoiding spelling mistakes and from producing clear query formulations, etc. Previous work on query completion algorithms returns a ranked list of queries to the users mostly based on the overall observed search popularity of query candidates in the whole query logs. However, the query search popularity could be changed over time, i.e., it's time-aware. Thus, these ranking approaches based on the overall search popularity could not work very well and users may fail to find an acceptable query in the returned list, resulting in a limited search satisfaction. Hence, this paper proposes a Learning-based Personalized Query Ranking approach, i.e., LQR, where the features on the observed and predicted search popularity both in the whole logs and the recent period are exploited. Taking a pair-wise learning scenario, this paper presents a method for generating a ranked list of query candidates, and then reranks the candidates by the similarity to current search context. The experimental results show the proposed approach outperforms the baseline in terms of Mean Reciprocal Rank (MRR), reporting an average MRR improvement of 7% against the baseline. [ABSTRACT FROM AUTHOR]

Angle-of-arrival(AOA) based passive localization is an important enabling technology in tracking systems. Previous work mainly focus on locating the target by making a coordinates estimation, while only a few provide ambiguous area estimation. The latter ones, however, are more applicable in military scenarios, e.g. warship tracking, since ambiguous area contains much more information than coordinates. This paper proposes a novel approach for ambiguous area estimation in AOA based localization. Comparing to existing work, confidence ellipse is used for area estimation instead of rectangle and circle. Theoretic model and parameter setting in practical uses are discussed. We conduct extensive simulations in different settings. Simulation results show that our approach provides a good tradeoff between the accuracy and the confidence for localization. It performs better than the previous work under the same localization condition based on a good performance of the tradeoff between the confidence and accuracy. [ABSTRACT FROM AUTHOR]

1,3:2,4-di- p-methylbenzylidene sorbitol (MDBS) is a small organic molecule that is capable of inducing self-assembly in a wide variety of organic solvents and of forming organogels. In this paper, we present a novel approach to tune the network architectures of organogels by utilizing geometric confinement while varying the gelator concentration. Self-assembly of MDBS in propylene carbonate (PC) is investigated in a series of microchannels with widths varying from 20 to 80 μm and the gelator concentration varying from 2 to 7 wt %. We demonstrate by optical microscopy and scanning electron microscopy (SEM) that a transition from fibrillar structure to sheaflike spherulite structure occurs when (a) the channel width is increased for fixed gelator concentrations and (b) gelator concentration is increased for fixed channel widths. A phase diagram is built based on these observations. Polarized microscopy and transmission electron microscopy (TEM) images are also obtained for organogel under unconfined condition to display the spherulite structures viewed under different length scales. The thermal properties of the organogel are measured by differential scanning calorimetry (DSC) to verify the structural difference obtained under confined and unconfined conditions and the structure stability. Our results provide a novel strategy to control the topological structure of self-assembled systems and to modify their thermal properties via geometric confinement. [ABSTRACT FROM AUTHOR]

Abstract  Ionically cross-linked polyampholytic hydrogels were synthesized by redox copolymerization of acrylamide and an ionic complex of (N,N-diethylamino)ethyl methacrylate and acrylic acid (designated as PADA hydrogel). The swelling behavior of the hydrogels in water indicated that a minimal equilibrium swelling ratio is found when the molar ratio of anionic/cationic monomers was 1.55. In NaCl solution, the hydrogels exhibited the typical swelling behavior of conventional polyampholytic gels. Their equilibrium swelling ratios increased with an increase in the NaCl concentration. In solutions of multivalent ions (CaCl2 and trisodium citrate solutions), the equilibrium swelling ratios of the hydrogels increased first and were then followed by a decrease with an increase in salt concentration. Interestingly, an unexpected abrupt swelling phenomenon was observed when the fully swollen hydrogels in salt solution were transmitted to pure water. The unique swelling behavior of PADA hydrogels depends not only on the molar ratio of the anionic/cationic monomers but also on the valency of the ions. [ABSTRACT FROM AUTHOR]

A four-point error separation technique integrating three-point roundness and two-point straightness error separations is proposed to measure and reconstruct a cylindrical profile for the accurate evaluation of cylindricity. Four probes mounted onto two sections in the probe carriage target the surface of the cylinder to detect the differential vector of the least-squares centers in two adjacent cross-sectional profiles of the cylinder. The vector of the least-squares center in each cross-sectional profile is extracted by accumulation. The spatial curved median line of the cylinder is determined by fitting the extracted least-squares centers. Theoretical analysis and numerical validation prove that radial error motions of the spindle and straightness error motions of the slider are eliminated during reconstruction of the cylindrical profile. The influence of tilt error motions of the spindle on the accuracy of error separation can be weakened by reducing the distance between the two sections in which the four probes are located. The spatial median line profile of the cylinder is accurately determined even if the error motions of the spindle are not repeatable in each revolution. An experimental system was constructed to perform comparison experiments. The results validate the fact that the technique has higher precision in reconstructing cylindrical profiles owing to its robust anti-interference ability. The technique is suitable for in situ measurement of cylindricity under unrepeatable radial error motions of the spindle and indeterminate straightness error motions of the slider. [ABSTRACT FROM AUTHOR]