101. Odor identification in frontotemporal lobar degeneration subtypes.
- Author
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Magerova H, Vyhnalek M, Laczo J, Andel R, Rektorova I, Kadlecova A, Bojar M, and Hort J
- Subjects
- Aged, Aged, 80 and over, Case-Control Studies, Female, Frontotemporal Dementia physiopathology, Frontotemporal Lobar Degeneration complications, Frontotemporal Lobar Degeneration physiopathology, Humans, Male, Middle Aged, Neuropsychological Tests, Olfaction Disorders physiopathology, Primary Progressive Nonfluent Aphasia physiopathology, Severity of Illness Index, Supranuclear Palsy, Progressive physiopathology, Frontotemporal Dementia complications, Odorants, Olfaction Disorders complications, Primary Progressive Nonfluent Aphasia complications, Supranuclear Palsy, Progressive complications
- Abstract
Odor identification impairment is a feature of several neurodegenerative disorders. Although neurodegenerative changes in the frontotemporal lobar degeneration (FTLD) subtypes involve areas important for olfactory processing, data on olfactory function in these patients are limited. An 18-item, multiple-choice odor identification test developed at our memory clinic, the Motol Hospital smell test, was administered to 9 patients with behavioral variant frontotemporal dementia, 13 patients with the language variants, primary nonfluent aphasia (n = 7) and semantic dementia (n = 6), and 8 patients with progressive supranuclear palsy. Compared to the control group (n = 15), all FTLD subgroups showed significant impairment of odor identification (P < .05). The differences between the FTLD subgroups were not significant. No correlation between odor identification and neuropsychological tests results was found. Our data suggest that odor identification impairment is a symptom common to FTLD syndromes, and it seems to be based on olfactory structure damage rather than cognitive decline., (© The Author(s) 2014.)
- Published
- 2014
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