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105. Does iron deficiency contribute to fatigue of patients with rheumatoid arthritis without anaemia?

Author

Vidal, F., Gillibert, A., Quillard, M., Fardellone, Patrice, Pouplin, S., Vittecoq, O., Lequerre, T., CHU Rouen, Normandie Université (NU), Laboratoire de biochimie générale [Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Service de rhumatologie [CHU Rouen], Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and DESSAIVRE, Louise

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Congress of the European-League-Against-Rheumatism (EULAR), Amsterdam, NETHERLANDS, JUN 13-16, 2018; International audience

Published
2018

108. THU0020 Tocilizumab decreases the pro-inflammatory role of platelets in rheumatoid arthritis: identification of a new mechanism of action associated with positive response?

Author

Prum Delepine, C., primary, Derambure, C., additional, Vidal, F., additional, Pinta, A., additional, Pau, D., additional, Conde da Silva Fraga, E., additional, Boyer, O., additional, Senbel, E., additional, Gaudin, P., additional, Vittecoq, O., additional, and Lequerre, T., additional

Published
2018
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111. SAT0470 Myositis, often suspected, is actually rare in primary sjÖgren’s syndrome: data from the french cohort assess

Author

Felten, R., primary, Seror, R., additional, Vittecoq, O., additional, Hachulla, E., additional, Perdriger, A., additional, Dieude, P., additional, Dubost, J.-J., additional, Fauchais, A.-L., additional, Guern, V.le, additional, Larroche, C., additional, Dernis, E., additional, Guellec, D., additional, Cornec, D., additional, Sibilia, J., additional, Gottenberg, J.-E., additional, and Meyer, A., additional

Published
2018
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113. Une urticaire atypique

Author

Janela-Lapert, R., primary, Tetart, F., additional, Bauvin, O., additional, Vittecoq, O., additional, and Joly, P., additional

Published
2018
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119. Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis

Author

Derambure, C., Dzangue-Tchoupou, G., Berard, C., Vergne, N., Hiron, M., D'Agostino, Maria Antonietta, Musette, P., Vittecoq, O., Lequerre, T., D'Agostino M. A. (ORCID:0000-0002-5347-0060), Derambure, C., Dzangue-Tchoupou, G., Berard, C., Vergne, N., Hiron, M., D'Agostino, Maria Antonietta, Musette, P., Vittecoq, O., Lequerre, T., and D'Agostino M. A. (ORCID:0000-0002-5347-0060)

Abstract

Background: In the current context of personalized medicine, one of the major challenges in the management of rheumatoid arthritis (RA) is to identify biomarkers that predict drug responsiveness. From the European APPRAISE trial, our main objective was to identify a gene expression profile associated with responsiveness to abatacept (ABA) + methotrexate (MTX) and to understand the involvement of this signature in the pathophysiology of RA. Methods: Whole human genome microarrays (4 × 44 K) were performed from a first subset of 36 patients with RA. Data validation by quantitative reverse-transcription (qRT)-PCR was performed from a second independent subset of 32 patients with RA. Gene Ontology and WikiPathways database allowed us to highlight the specific biological mechanisms involved in predicting response to ABA/MTX. Results: From the first subset of 36 patients with RA, a combination including 87 transcripts allowed almost perfect separation between responders and non-responders to ABA/MTX. Next, the second subset of patients 32 with RA allowed validation by qRT-PCR of a minimal signature with only four genes. This latter signature categorized 81% of patients with RA with 75% sensitivity, 85% specificity and 85% negative predictive value. This combination showed a significant enrichment of genes involved in electron transport chain (ETC) pathways. Seven transcripts from ETC pathways (NDUFA6, NDUFA4, UQCRQ, ATP5J, COX7A2, COX7B, COX6A1) were significantly downregulated in responders versus non-responders to ABA/MTX. Moreover, dysregulation of these genes was independent of inflammation and was specific to ABA response. Conclusion: Pre-silencing of ETC genes is associated with future response to ABA/MTX and might be a crucial key to susceptibility to ABA response.

Published
2017

120. Association between RANK, RANKL and OPG polymorphisms with ACPA and erosions in rheumatoid arthritis: results from a meta-analysis involving three French cohorts

Author

Ruyssen-Witrand, Adeline, Degboe, Yannick, Cantagrel, A., Nigon, D., Lukas, C., Scaramuzzino, S, Allanore, A., Vittecoq, O., Schaeverbeke, S, Morel, J., Sibilia, S, Cambon-Thomsen, A., Dieudé, D, Constantin, A, Saraux, Alain, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Service de rhumatologie, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Centre Hospitalier Universitaire de Purpan (CHU Purpan), Centre de rhumatologie, CHU Purpan, Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Service de rhumatologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)

Subjects
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2016

121. Gradual conversion of cellular stress patterns into pre-stressed matrix architecture during in vitro tissue growth

Author

Eble, V., Legallicier, B., Vittecoq, O., Caron, F., Tamion, F., Ducrotté, P., Lévesque, H., Menard, J.-F., Guerrot, D., Marié, I., Commin, M.-H., Schmidt, E., Duvert-Lehembre, S., Lasek, A., Morice, C., Estival, J.-L., Debarbieux, S., Rigal, E., Pauwels, C., De Quatrebarbes, J., Roussel, A., Goujon, E., Stoebner, P.-E., Jouen, F., Bidan, Cécile, Kollmannsberger, Philip, Gering, Vanessa, Ehrig, Sebastian, Joly, Pascal, Petersen, Ansgar, Vogel, Viola, Fratzl, Peter, Dunlop, John, Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Néphrologie [Rouen], Service de rhumatologie [CHU Rouen], Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Unité de biostatistiques [CHU Rouen], Service de Dermatologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Laboratoire d'aérothermique (LA), Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Service de Dermatologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Département Technique Conversion et Hydrogène (DTCH), Laboratoire d'Innovation pour les Technologies des Energies Nouvelles et les nanomatériaux (LITEN), Institut National de L'Energie Solaire (INES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de L'Energie Solaire (INES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Max Planck Institute of Colloids and Interfaces, Max-Planck-Gesellschaft, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Department of Biomaterials [Potsdam], Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Hôpital Charles Nicolle [Rouen], Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
0301 basic medicine, Ceramics, [SDV]Life Sciences [q-bio], Biomedical Engineering, Biophysics, Bioengineering, Nanotechnology, Matrix (biology), Fibril, Biochemistry, Cell Line, Biomaterials, Extracellular matrix, 03 medical and health sciences, Mice, Stress, Physiological, tissue growth, extracellular matrix organization, tissue mechanics, Animals, Cytoskeleton, ComputingMilieux_MISCELLANEOUS, Osteoblasts, Tissue Scaffolds, Chemistry, Osteoid, Life Sciences–Physics interface, Cell biology, Extracellular Matrix, 030104 developmental biology, Cell culture, [SDV.IMM]Life Sciences [q-bio]/Immunology, Function (biology), Biotechnology, Extracellular matrix organization
Abstract

The complex arrangement of the extracellular matrix (ECM) produced by cells during tissue growth, healing and remodelling is fundamental to tissue function. In connective tissues, it is still unclear how both cells and the ECM become and remain organized over length scales much larger than the distance between neighbouring cells. While cytoskeletal forces are essential for assembly and organization of the early ECM, how these processes lead to a highly organized ECM in tissues such as osteoid is not clear. To clarify the role of cellular tension for the development of these ordered fibril architectures, we used an in vitro model system, where pre-osteoblastic cells produced ECM-rich tissue inside channels with millimetre-sized triangular cross sections in ceramic scaffolds. Our results suggest a mechanical handshake between actively contracting cells and ECM fibrils: the build-up of a long-range organization of cells and the ECM enables a gradual conversion of cell-generated tension to pre-straining the ECM fibrils, which reduces the work cells have to generate to keep mature tissue under tension.

Published
2016

124. AB0395 Subcutaneous tocilizumab as monotherapy or in combination with a csdmard in patients with rheumatoid arthritis: 24 weeks results of the french phase iiib study, “tosca”

Author

Fautrel, B, primary, Senbel, E, additional, Vittecoq, O, additional, Rist, S, additional, Combe, B, additional, Schaeverbeke, T, additional, Lioté, F, additional, Flipo, R-M, additional, Baffie, C, additional, Pau, D, additional, Fraga, E Condé Da Silva, additional, Pinta, A, additional, and Gaudin, P, additional

Published
2017
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128. OP0189 High Grade Salivary Gland Involvement, Assessed by Histology or Ultrasonography, Is Associated with a Poor Response to Rituximab in Primary Sjögren's Syndrome Patients: Figure 1

Author

Cornec , D., Jousse-Joulin , S., Costa , S., Marhadour , T., Marcorelles , P., Berthelot , J.-M., Hachulla , E., Hatron , P.-Y., Goeb , V., Vittecoq , O., Nowak , E., Pers , J.-O., Devauchelle-Pensec , V., Saraux , A., Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Littoral, Environnement, Télédétection, Géomatique ( LETG - Caen ), Littoral, Environnement, Télédétection, Géomatique ( LETG ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Université d'Angers ( UA ) -Université de Nantes ( UN ) -École pratique des hautes études ( EPHE ) -Université de Brest ( UBO ) -Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Caen Normandie ( UNICAEN ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Service d'Anatomie Pathologique, Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Service de médecine interne, Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Service de rhumatologie [Rouen], CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Centre d'Investigation Clinique ( CIC - Brest ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Littoral, Environnement, Télédétection, Géomatique (LETG - Caen), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de rhumatologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Investigation Clinique (CIC - Brest), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.IMM]Life Sciences [q-bio]/Immunology, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

129. Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results from the APPRAISE study

Author

D'Agostino, Maria Antonietta, Wakefield, R. J., Berner-Hammer, H., Vittecoq, O., Filippou, G., Balint, P., Moller, I., Iagnocco, A., Naredo, E., Ostergaard, M., Boers, M., Gaillez, C., Van Holder, K., Le Bars, M., D'Agostino M. A. (ORCID:0000-0002-5347-0060), D'Agostino, Maria Antonietta, Wakefield, R. J., Berner-Hammer, H., Vittecoq, O., Filippou, G., Balint, P., Moller, I., Iagnocco, A., Naredo, E., Ostergaard, M., Boers, M., Gaillez, C., Van Holder, K., Le Bars, M., and D'Agostino M. A. (ORCID:0000-0002-5347-0060)

Abstract

Objectives To study the responsiveness of a combined power Doppler and greyscale ultrasound (PDUS) score for assessing synovitis in biologic-naave patients with rheumatoid arthritis (RA) starting abatacept plus methotrexate (MTX). Methods In this open-label, multicentre, single-arm study, patients with RA (MTX inadequate responders) received intravenous abatacept (∼10 mg/kg) plus MTX for 24 weeks. A composite PDUS synovitis score, developed by the Outcome Measures in Rheumatology- European League Against Rheumatism (OMERACT- EULAR)-Ultrasound Task Force, was used to evaluate individual joints. The maximal score of each joint was added into a Global OMERACT-EULAR Synovitis Score (GLOESS) for bilateral metacarpophalangeal joints (MCPs) 2-5 ( primary objective). The value of GLOESS containing other joint sets was explored, along with clinical efficacy. Results Eighty-nine patients completed the 24-week treatment period. The earliest PDUS sign of improvement in synovitis was at week 1 (mean change in GLOESS (MCPs 2-5): -0.7 (95% CIs -1.2 to -0.1)), with continuous improvement to week 24. Early improvement was observed in the component scores (power Doppler signal at week 1, synovial hyperplasia at week 2, joint effusion at week 4). Comparable changes were observed for 22 paired joints and minimal joint subsets. Mean Disease Activity Score 28 (C reactive protein) was significantly reduced from weeks 1 to 24, reaching clinical meaningful improvement (change ≥1.2) at week 8. Conclusions In this first international prospective study, the composite PDUS score is responsive to abatacept. GLOESS demonstrated the rapid onset of action of abatacept, regardless of the number of joints examined. Ultrasound is an objective tool to monitor patients with RA under treatment.

Published
2016

130. Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: Results from the APPRAISE study

Author

D'Agostino, Maria Antonietta, Boers, M., Wakefield, R. J., Hammer, H. B., Vittecoq, O., Filippou, G., Balint, P., Moller, I., Iagnocco, A., Naredo, E., Ostergaard, M., Gaillez, C., Le Bars, M., D'Agostino M. A. (ORCID:0000-0002-5347-0060), D'Agostino, Maria Antonietta, Boers, M., Wakefield, R. J., Hammer, H. B., Vittecoq, O., Filippou, G., Balint, P., Moller, I., Iagnocco, A., Naredo, E., Ostergaard, M., Gaillez, C., Le Bars, M., and D'Agostino M. A. (ORCID:0000-0002-5347-0060)

Abstract

Objectives: To explore whether changes in a composite ( power Doppler/greyscale ultrasound (PDUS)) synovitis score, developed by the OMERACT-EULAR-Ultrasound Task Force, predict disease activity outcomes in rheumatoid arthritis (RA). Methods: Patients with RA who were methotrexate inadequate responders starting abatacept were evaluated. Individual joint PDUS scores were combined in the Global OMERACT-EULAR Synovitis Score (GLOESS) for metacarpophalangeal joints (MCPs) 2-5, all joints (22 paired) and a reduced (9 paired) joint set. The predictive value of changes in GLOESS at week 1-16 evaluations for clinical status and response (Disease Activity Score (DAS) 28 (C reactive protein, CRP) <2.6; DAS28(CRP) ≤3.2; DAS28(CRP) ≥1.2 improvement) up to week 24, and correlations between DAS28 and GLOESS were assessed. Results: Eighty-nine patients completed the 24-week treatment period. Changes in GLOESS (MCPs 2-5) from weeks 1 to 16 were unable to predict DAS28 outcomes up to week 24. However, significant improvements in GLOESS (MCPs 2-5) were observed at week 12 in patients with DAS28 ≥1.2 improvement at week 24 versus those who did not achieve that clinical response. In patients achieving DAS28 ≥1.2 improvement or DAS28 ≤3.2 at week 24, changes in GLOESS (22 and 9 paired joint sets) were greater in patients who already achieved DAS28 ≥1.2 at week 12 than in those who did not. No significant correlations were found between changes in DAS28 and GLOESS definitions at any time point. Conclusions: PDUS was not correlated with clinical status or response as measured by DAS28-derived criteria, and PDUS changes were not predictive of clinical outcome. The discrepancies require further exploration. Trial registration number: NCT00767325; Results.

Published
2016

136. Analyse comparative des registres de la SFR AIR, ORA et REGATE : un maintien thérapeutique différent en pratique courante

Author

Gottenberg, J.E., primary, Morel, J., additional, Constantin, A., additional, Bardin, T., additional, Cantagrel, A., additional, Combe, B., additional, Dougados, M., additional, Flipo, R.M., additional, Saraux, A., additional, Schaeverbeke, T., additional, Sibilia, J., additional, Soubrier, M., additional, Vittecoq, O., additional, Perrodeau, E., additional, Ravaud, P., additional, and Mariette, X., additional

Published
2016
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137. Facteurs associés aux formes sévères de spondyloarthropathie axiale : résultats de l’étude nationale multicentrique Bamboospine

Author

Gross, J., primary, Singvongsa, S., additional, Molto, A., additional, Etcheto, A., additional, Allanore, Y., additional, Balandraud, N., additional, Boissier, M.C., additional, Boumier, P., additional, Brocq, O., additional, Claudepierre, P., additional, Devauchelle Pensec, V., additional, Fautrel, B., additional, Gaudin, P., additional, Le Goff, B., additional, Loeuille, D., additional, Pavy, S., additional, Richette, P., additional, Ruyssen-Witrand, A., additional, Saint Marcoux, B., additional, Sellam, J., additional, Soubrier, M., additional, Thomas, T., additional, Vittecoq, O., additional, Wendling, D., additional, Dougados, M., additional, and Miceli Richard, C., additional

Published
2016
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139. Efficacité et tolérance de tocilizumab par voie sous-cutanée en monothérapie ou en association aux csDMARDs chez des patients atteints de polyarthrite rhumatoïde : résultats à 24 semaines de l’étude française TOSCA

Author

Fautrel, B., primary, Senbel, E., additional, Vittecoq, O., additional, Rist, S., additional, Combe, B., additional, Schaeverbeke, T., additional, Lioté, F., additional, Flipo, R.M., additional, Kamar, D., additional, Pau, D., additional, Conde Da Silva Fraga, E., additional, Pinta, A., additional, and Gaudin, P., additional

Published
2016
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140. Risque de complications systémiques au cours du syndrome de Sjögren primitif et rôle prédictif de la numération sanguine, de l’EPP, du dosage du complément, et de la recherche d’une cryoglobulinémie: données de la cohorte prospective de la SFR ASSESS

Author

Gottenberg, J.E., primary, Seror, R., additional, Saraux, A., additional, Devauchelle Pensec, V., additional, Dernis, E., additional, Dieudé, P., additional, Dubost, J.J., additional, Fauchais, A.L., additional, Goeb, V., additional, Larroche, C., additional, Le Guern, V., additional, Hachulla, E., additional, Hatron, P.Y., additional, Morel, J., additional, Perdriger, A., additional, Rist, S., additional, Sene, D., additional, Vittecoq, O., additional, Sibilia, J., additional, Ravaud, P., additional, and Mariette, X., additional

Published
2016
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142. La tolérance à long terme du rituximab, de l’abatacept et du tocilizumab est similaire d’après les données des registres AIR, ORA et REGATE de la SFR

Author

Gottenberg, J.E., primary, Morel, J., additional, Constantin, A., additional, Bardin, T., additional, Cantagrel, A., additional, Combe, B., additional, Dougados, M., additional, Flipo, R.M., additional, Saraux, A., additional, Schaeverbeke, T., additional, Sibilia, J., additional, Soubrier, M., additional, Vittecoq, O., additional, Perrodeau, E., additional, Ravaud, P., additional, and Mariette, X., additional

Published
2016
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143. Association betweenRANK, RANKLandOPGpolymorphisms with ACPA and erosions in rheumatoid arthritis: results from a meta-analysis involving three French cohorts

Author

Ruyssen-Witrand, Adeline, primary, Degboé, Yannick, additional, Cantagrel, A, additional, Nigon, D, additional, Lukas, C, additional, Scaramuzzino, S, additional, Allanore, Y, additional, Vittecoq, O, additional, Schaeverbeke, T, additional, Morel, J, additional, Sibilia, J, additional, Cambon-Thomsen, A, additional, Dieudé, P, additional, and Constantin, A, additional

Published
2016
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144. SAT0208 Inflammatory Myopathies Associated with Sjögren's Syndrome Do Not Differ from Those without Sjögren's Syndrome Aside from Older Age at Diagnosis and Less Frequent Normal Muscle Biopsy

Author

Meyer, A., primary, Maurier, F., additional, Larroche, C., additional, Tournadre, A., additional, Dieudé, P., additional, Dernis, E., additional, Vittecoq, O., additional, Dubost, J.-J., additional, Fauchais, A.-L., additional, Mariette, X., additional, Sibilia, J., additional, and Gottenberg, J.-E., additional

Published
2016
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