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Carbon monoxide (CO), acetylene (C2H2), ethane (C2H6), formaldehyde (H2CO), and hydrogen cyanide (HCN) are important trace gases in the atmosphere. They are highly related to biomass burning, fossil fuel combustion, and biogenic emissions globally, affecting air quality and climate change. However, the variations and correlations among these species are not well known in northern China due to limited measurements. In June 2018, we installed a new ground-based Fourier transform infrared (FTIR) spectrometer (Bruker IFS 125HR) recording mid-infrared high spectral resolution solar-absorption spectra at Xianghe (39.75∘ N, 116.96∘ E), China. In this study, we use the latest SFIT4 code, together with advanced a priori profiling and spectroscopy, to retrieve these five species from the FTIR spectra measured between June 2018 and November 2021. The retrieval strategies, retrieval information and retrieval uncertainties are presented and discussed. For the first time, the time series, variations, and correlations of these five species are analyzed at a typical polluted site in northern China. The seasonal variations in C2H2 and C2H6 total columns show a maximum in winter–spring and a minimum in autumn, whereas the seasonal variations in H2CO and HCN show a maximum in summer and a minimum in winter. Unlike the other four species, the FTIR measurements show that there is almost no seasonal variation in the CO column. The correlation coefficients (R) between the synoptic variations in CO and the other four species (C2H2, C2H6, H2CO, and HCN) are between 0.68 and 0.80, indicating that they are affected by common sources. Using the FLEXPART model backward simulations and satellite fire measurements, we find that the variations in CO, C2H2, C2H6, and H2CO columns are mainly dominated by the local anthropogenic emissions, while HCN column observed at Xianghe is a good tracer to identify fire emissions.

This article presents the results of the archaeological, bioanthropological, and historical analysis of an atypical human bone deposit found at the medieval Islamic desert site of Khirbat al-Dusaq in southern present-day Jordan. This site has yielded several human remains deposits, most of which appear to be either ordinary or reorganised burials with a clearly identifiable sepulchral function. However, one particular deposit (labelled “Structure no 1 (Pièce 5)”) displays several atypical features which complicate its interpretation. As such, radiocarbon dating of this particular deposit indicates a chronological range extending from the second half of the seventeenth century CE to the end of the eighteenth century CE. In addition, the human bones contained within this deposit tend to show unusual osteological characteristics, such as possible cut marks resembling peri-mortem lesions inflicted upon the deceased by third parties armed with sharp objects. The precise historical contextualisation of this deposit enables us to discuss different scenarios that could explain the circumstances of its inception. In this sense, the spectrum of possible explanatory interpretations ranges from the conjecture that the remains under study represent one or several victims of an inter-tribal conflict, a brigandage or retaliation attack, a crushed popular uprising, or even individuals who died during one of the violent raids perpetrated by local Bedouin tribes against the Mecca pilgrimage caravans during the Ottoman period.

Background There is limited information regarding the effects of pediatric chronic pain management on the number and cost of chronic pain–related emergency department (ED) consultations.Aim This retrospective study aimed to evaluate the number and costs of chronic pain–related ED consultations of children and adolescents with chronic pain conditions at the Montreal Children’s Hospital (MCH).Methods Charts of patients followed by the Edwards Family Interdisciplinary Center for Complex Pain (CCP) of the MCH between April 2017 and December 2018 were reviewed. ED consultations, specialist consultations, medication prescriptions, hospital admissions, and outpatient consultation referrals were assessed for the period of 1 year before and after the patients’ first consultation with the CCP. Associated costs were also calculated.Results One-hundred sixty-eight patients were included in the analysis. Fifty-one percent consulted the ED and had 151 chronic pain–related ED consultations within 1 year before their initial CCP consultation. In the year following their first CCP consultation, 52 patients (31%) consulted the ED, of which 24 consultations were chronic pain–related (84% reduction). There was an 81% reduction in the costs associated with chronic pain–related ED consultations within 1 year after CCP management. In addition, there was a significant reduction in ED interventions within 1 year after CCP management, though there was no change in medication prescriptions, hospital admissions, or subspecialist consultations.Conclusion Children and adolescents with chronic pain conditions had fewer chronic pain–related ED consultations within 1 year after the first evaluation by an interdisciplinary center for complex pain, contributing to reduced ED costs.

This study presents an updated evaluation of stratospheric ozone profile trends in the 60∘ S–60∘ N latitude range over the 2000–2020 period using an updated version of the Long-term Ozone Trends and Uncertainties in the Stratosphere (LOTUS) regression model that was used to evaluate such trends up to 2016 for the last WMO Ozone Assessment (2018). In addition to the derivation of detailed trends as a function of latitude and vertical coordinates, the regressions are performed with the datasets averaged over broad latitude bands, i.e. 60–35∘ S, 20∘ S–20∘ N and 35–60∘ N. The same methodology as in the last assessment is applied to combine trends in these broad latitude bands in order to compare the results with the previous studies. Longitudinally resolved merged satellite records are also considered in order to provide a better comparison with trends retrieved from ground-based records, e.g. lidar, ozonesondes, Umkehr, microwave and Fourier transform infrared (FTIR) spectrometers at selected stations where long-term time series are available. The study includes a comparison with trends derived from the REF-C2 simulations of the Chemistry Climate Model Initiative (CCMI-1). This work confirms past results showing an ozone increase in the upper stratosphere, which is now significant in the three broad latitude bands. The increase is largest in the Northern and Southern Hemisphere midlatitudes, with ∼2.2 ± 0.7 % per decade at ∼2.1 hPa and ∼2.1 ± 0.6 % per decade at ∼3.2 hPa respectively compared to ∼1.6 ± 0.6 % per decade at ∼2.6 hPa in the tropics. New trend signals have emerged from the records, such as a significant decrease in ozone in the tropics around 35 hPa and a non-significant increase in ozone in the southern midlatitudes at about 20 hPa. Non-significant negative ozone trends are derived in the lowermost stratosphere, with the most pronounced trends in the tropics. While a very good agreement is obtained between trends from merged satellite records and the CCMI-1 REF-C2 simulation in the upper stratosphere, observed negative trends in the lower stratosphere are not reproduced by models at southern and, in particular, at northern midlatitudes, where models report an ozone increase. However, the lower-stratospheric trend uncertainties are quite large, for both measured and modelled trends. Finally, 2000–2020 stratospheric ozone trends derived from the ground-based and longitudinally resolved satellite records are in reasonable agreement over the European Alpine and tropical regions, while at the Lauder station in the Southern Hemisphere midlatitudes they show some differences.

Examinar una tradición de levantamientos de inspección visual fundamentados en evidencia empírica representa la base para el desarrollo de un asistente digital (App) como instrumento de diagnóstico y valoración de estructuras en albañilería simple durante la post-emergencia sísmica. La integración de los códigos observacionales derivados de esta tradición permitió la calibración y el análisis de las técnicas de levantamiento y medición utilizadas. El asistente aprovecha las tecnologías ampliamente disponibles en la población e integra los conocimientos especializados y las técnicas tradicionales derivadas del levantamiento directo como base analítica para la valoración de los daños. Esta dimensión analítica de la representación del daño es uno de los aspectos críticos que establece las correlaciones entre los códigos visuales y las escalas de valoración del algoritmo que determina el riesgo sísmico y el grado de habitabilidad estructural de las viviendas.

Sport climbing performance is highly related to upper limb strength and endurance. Although finger-specific methods are widely analyzed in the literature, no study has yet quantified the effects of arm-specific training. This study aims to compare the effects of three types of training involving different muscle contraction regimens on climbers’ pull-up capabilities. Thirty advanced to high-elite climbers were randomly divided into four groups: eccentric (ECC; n = 8), isometric (ISO; n = 7), plyometric (PLYO; n = 6), and no specific training (CTRL; n = 9), and they participated in a 5-week training, twice a week, focusing on pull-ups on hangboard. Pre- and post-training assessments were conducted using a force-sensing hangboard, analyzing force, velocity, power, and muscle work during three pull-up exercises: pull-ups at body weight under different conditions, incremental weighted pull-ups, and an exhaustion test. The CTRL group showed no change. Maximum strength improved in all three training groups (from +2.2 ± 3.6% to +5.0 ± 2.4%; p < 0.001); velocity variables enhanced in the ECC and PLYO groups (from +5.7 ± 7.4 to +28.7 ± 42%; p < 0.05), resulting in greater power; amplitude increased in the ECC group; and muscle work increased in the PLYO group (+21.9 ± 16.6%; p = 0.015). A 5-week training period effectively enhanced arm performance, but outcomes were influenced by the chosen muscle contraction regimens and initial individual characteristics.

Trait anxiety, emotion regulation strategies, and metacognitive beliefs influence executive functions (EFs) and academic achievement. This study examines their interplay and impact on academic success. In total, 275 adolescents (10–17 years) and parents completed an online questionnaire assessing trait anxiety, emotion regulation strategies, metacognition, parent-reported behaviors related to executive functioning, and overall school average. Preliminary analyses confirmed consistency with the existing literature for each variable and their interaction. Furthermore, we conducted a network analysis among the main variables. This analysis supports the need to pay more attention to reflective variables—maladaptive emotion regulation strategies and metacognitive beliefs about worry—when studying trait anxiety. These variables were linked to problematic executive functioning in adolescents, and the latter was negatively linked to academic achievement. This study offers innovative insights by investigating relationships less explored in the scientific literature. It reveals high and significant correlations between metacognitive beliefs, maladaptive emotion regulation strategies, and trait anxiety (r > 0.500, p < 0.001) but also between these variables and both executive functioning and academic achievement. These findings offer new perspectives for research and underscore the importance of holistically examining the psychological factors related to academic success.

Even before the current pandemic, university students were known to have high levels of hassles, anxiety, and depressive symptoms. In all probability, the advent of COVID-19 has substantially raised these levels. The present study measured the emotional state of university students during lockdown and identified the relevant situational and psychological factors. To this end, 1,297 French university students were assessed during lockdown, which lasted from 16 March to 11 May in France. Situational factors included the belief that lockdown was compromising their future job prospects, COVID-19 symptoms, and health concerns. Psychological factors included students' implicit theory of emotion, and the coping strategies they used during lockdown. We explored the extent to which these factors were associated with levels of hassles, anxiety, and depressive symptoms. Results indicated that students' belief that lockdown was compromising their future job prospects was positively related to hassles (r = 0.34, p < 0.001), while concerns about their own health and that of relatives were positively associated with anxiety (r = 0.37 and 0.34; p < 0.001). In addition, use of the positive reframing coping strategy mediated the effect of students' implicit theory of emotion on their depressive symptoms. Even though the national lockdown is now over, the pandemic will continue to have a major impact on university students over the coming months. It is therefore essential for universities to provide them with adequate psychological support.

Abstract Background Some conventional vaccines have been recognized as a cause of secondary immune thrombocytopenia (ITP). According to recent publications, mRNA vaccines are probably associated with an increased risk of ITP. Case presentation Our patient developed severe ITP one week after the second dose of COVID-19 mRNA vaccine. Medical management was not effective, requiring splenectomy to obtain sustained remission. Conclusion Considering the temporality and immunological hypothesis, we consider the vaccine to be the trigger of this ITP. To our knowledge, our case is, to date, the most severe case of ITP reported following SARS-CoV-2 vaccination and could help for the therapeutic management of similar patients.

Abstract Background Bulk segregant analysis (BSA) combined with next generation sequencing is a powerful tool to identify quantitative trait loci (QTL). The impact of the size of the study population and the percentage of extreme genotypes analysed have already been assessed. But a good comparison of statistical approaches designed to identify QTL regions using next generation sequencing (NGS) technologies for BSA is still lacking. Results We developed an R code to simulate QTLs in bulks of F2 contrasted lines. We simulated a range of recombination rates based on estimations using different crop species. The simulations were used to benchmark the ability of statistical methods identify the exact location of true QTLs. A single QTL led to a shift in allele frequency across a large fraction of the chromosome for plant species with low recombination rate. The smoothed version of all statistics performed best notably the smoothed Euclidean distance-based statistics was always found to be more accurate in identifying the location of QTLs. We propose a simulation approach to build confidence interval statistics for the detection of QTLs. Conclusion We highlight the statistical methods best suited for BSA studies using NGS technologies in crops even when recombination rate is low. We also provide simulation codes to build confidence intervals and to assess the impact of recombination for application to other studies. This computational study will help select NGS-based BSA statistics that are useful to the broad scientific community.

Abstract The rhizosheath, the layer of soil that adheres strongly to roots, influences water and nutrients acquisition. Pearl millet is a cereal crop that plays a major role for food security in arid regions of sub-Saharan Africa and India. We previously showed that root-adhering soil mass is a heritable trait in pearl millet and that it correlates with changes in rhizosphere microbiota structure and functions. Here, we studied the correlation between root-adhering soil mass and root hair development, root architecture, and symbiosis with arbuscular mycorrhizal fungi and we analysed the genetic control of this trait using genome wide association (GWAS) combined with bulk segregant analysis and gene expression studies. Root-adhering soil mass was weakly correlated only to root hairs traits in pearl millet. Twelve QTLs for rhizosheath formation were identified by GWAS. Bulk segregant analysis on a biparental population validated five of these QTLs. Combining genetics with a comparison of global gene expression in the root tip of contrasted inbred lines revealed candidate genes that might control rhizosheath formation in pearl millet. Our study indicates that rhizosheath formation is under complex genetic control in pearl millet and suggests that it is mainly regulated by root exudation.

It is unclear how far the impact of deforestation can spread. Here the authors analyse freshwater eDNA data along two rivers in the Amazon forest, and find that low levels of deforestation are linked to substantial reductions of fish and mammalian diversity downstream.

Our objective was to highlight age-related differences in subjective affect and its variations between adolescence and old age in an ecological environment, running generalized additive models to look for nonlinear relationships between age and affect. The originality of this research lay in its consideration of the levels of both affective valence and affect activation. Over a 2-week period, 209 participants aged 13-80 years completed a daily survey based on the experience sampling method, each providing an average of 60 observations. Results revealed 1) two nonlinear patterns of age-related differences in affective valence during the first (declines in deactivated negative affect and deactivated positive affect) and second (continuing decline in deactivated negative affect and increase in deactivated positive affect) halves of adulthood, and 2) one linear pattern of age-related differences in affect variation in the shape of a two-step reduction in the amplitude of variation, with a more marked reduction in the second half of adulthood. Results are discussed in the light of age differences in motivation and affect regulation expertise., Author(s): Sarah Le Vigouroux [sup.1] , Bruno Dauvier [sup.2] , Anne Congard [sup.3] Author Affiliations: (1) grid.48959.39, 0000 0004 0647 1372, EA 7352, CHROME, Team APSY-v, Nîmes University, , rue [...]

Abstract We validate formaldehyde (HCHO) vertical column densities (VCDs) from Ozone Mapping and Profiler Suite Nadir Mapper (OMPS‐NM) instruments onboard the Suomi National Polar‐orbiting Partnership (Suomi NPP) satellite for 2012–2020 and National Oceanic and Atmospheric Administration‐20 (NOAA‐20) satellite for 2018–2020, hereafter referred to as OMPS‐NPP and OMPS‐N20, with ground‐based Fourier‐Transform Infrared (FTIR) observations of the Network for the Detection of Atmospheric Composition Change (NDACC). OMPS‐NPP/N20 HCHO products reproduce seasonal variability at 24 FTIR sites. Monthly variability of OMPS‐NPP/N20 has a very good agreement with FTIR, showing correlation coefficients of 0.83 and 0.88, respectively. OMPS‐NPP (N20) biases averaged over all sites are −0.9 (4) ± 3 (6)%. However, at clean sites (with VCDs 4.0 × 1015 molecules cm−2, negative biases of −15% ± 4% appear for OMPS‐NPP, but OMPS‐N20 shows smaller bias of 0.5% ± 6% due to its smaller ground pixel footprints. Therefore, smaller satellite footprint sizes are important in distinguishing small‐scale plumes. In addition, we discuss a bias correction and provide lower limit for the monthly uncertainty of OMPS‐NPP/N20 HCHO products. The total uncertainty for OMPS‐NPP (N20) at clean sites is 0.7 (0.8) × 1015 molecules cm−2, corresponding to a relative uncertainty of 32 (30)%. In the case of HCHO VCDs > 4.0 × 1015 molecules cm−2, however, the relative uncertainty in HCHO VCDs for OMPS‐NPP (N20) decreases to 31 (18)%.

IntroductionWomen with disabilities are exposed to sexism and ableism, earn less income, and work in exceptionally challenging conditions compared to women without disabilities and men with or without disabilities. Adolescent girls living with scoliosis may begin experiencing this compounding bias during their encounters with healthcare from the moment they start noticing differences in their bodies. Being significantly more likely than boys to progress to a curve angle where painful treatment such as bracing or spinal fusion surgery is required, adolescent girls living with scoliosis are therefore more likely to experience chronic pain. The long-term impact of pain and pain-related stigma includes lower educational attainments, decreased vocational functionality, and social impairments in adults after having experienced chronic pain in adolescence.ApproachIn this article, the authors will explore the effects and mechanisms of gender-specific peer support in disrupting this trajectory to adverse outcomes. Through individual interviews consisting of open-ended questions, the researchers gathered narrative data from Curvy Girls members, a community-based peer support group for girls and young women living with scoliosis. The data was analyzed using an applied philosophical hermeneutics approach, with intersectionality and testimonial injustice as their framework.FindingsThey found that the study participants had their pain narratives reinterpreted by the adults in their lives, including their parents and healthcare practitioners, leading them to question and doubt their own experiences.DiscussionThese negative outcomes were mitigated through the peer support they received and offered from Curvy Girls. Participants reported having gained confidence and a sense of belonging after they joined this group, allowing them to better cope with their condition more effectively in different facets of their lives.

ABSTRACT Phazolicin (PHZ) is a peptide antibiotic exhibiting narrow-spectrum activity against rhizobia closely related to its producer, Rhizobium sp. strain Pop5. Here, we show that the frequency of spontaneous PHZ-resistant mutants in Sinorhizobium meliloti is below the detection limit. We find that PHZ can enter S. meliloti cells through two distinct promiscuous peptide transporters, BacA and YejABEF, which belong to the SLiPT (SbmA-like peptide transporter) and ABC (ATP-binding cassette) transporter families, respectively. The dual-uptake mode explains the lack of observed resistance acquisition because the simultaneous inactivation of both transporters is necessary for resistance to PHZ. Since both BacA and YejABEF are essential for the development of functional symbiosis of S. meliloti with leguminous plants, the unlikely acquisition of PHZ resistance via the inactivation of these transporters is further disfavored. A whole-genome transposon sequencing screen did not reveal additional genes that can provide strong PHZ resistance when inactivated. However, it was found that the capsular polysaccharide KPS, the novel putative envelope polysaccharide PPP (PHZ-protecting polysaccharide), as well as the peptidoglycan layer jointly contribute to the sensitivity of S. meliloti to PHZ, most likely serving as barriers that reduce the amount of PHZ transported inside the cell. IMPORTANCE Many bacteria produce antimicrobial peptides to eliminate competitors and create an exclusive niche. These peptides act either by membrane disruption or by inhibiting essential intracellular processes. The Achilles’ heel of the latter type of antimicrobials is their dependence on transporters to enter susceptible cells. Transporter inactivation results in resistance. Here, we show that a rhizobial ribosome-targeting peptide, phazolicin (PHZ), uses two different transporters, BacA and YejABEF, to enter the cells of a symbiotic bacterium, Sinorhizobium meliloti. This dual-entry mode dramatically reduces the probability of the appearance of PHZ-resistant mutants. Since these transporters are also crucial for S. meliloti symbiotic associations with host plants, their inactivation in natural settings is strongly disfavored, making PHZ an attractive lead for the development of biocontrol agents for agriculture.

AbstractPearl millet (Pennisetum glaucumCenchrus americanus

University students are a vulnerable population, and many recent studies show that anxiety, depressive symptoms, and academic burnout have been on the increase since the beginning of the COVID-19 pandemic. These findings point to a need for interventions to reduce these difficulties. The purpose of the present study was to assess the effects of 2 formats of an innovative program on students’ mental health (anxiety, depressive symptoms, and academic burnout), intolerance of uncertainty, learned helplessness, and learning. Our sample was composed of 105 university students, recruited on a voluntary basis. They were divided into 3 groups: online intervention group (n = 36), face-to-face intervention group (n = 32), and control group (n = 37). The following variables were measured through online questionnaires: anxiety and depressive symptoms, academic burnout, intolerance of uncertainty, learned helplessness, perceived social support, learning strategies, and beliefs. There were 2 assessments 10 weeks apart (ie, before and after the program in the case of the 2 intervention groups). We performed nonparametric analyses to run comparisons between the 2 assessment timepoints in each group. Results showed that participants in the 2 intervention groups had lower levels of learned helplessness and intolerance of uncertainty at the end of the program. Furthermore, participants in the face-to-face group reported higher levels of perceived social support, academic self-efficacy, and help-seeking strategies. The present study highlighted the benefits of our innovative program, especially its face-to-face format. Clinical Trial - ID: NCT04978194.