Search

Your search keyword '"Van Der Woude, Fokko J."' showing total 420 results
Start Over Author "Van Der Woude, Fokko J."
420 results on '"Van Der Woude, Fokko J."'

105. Development and standardization of solid phase assays for the detection of anti-neutrophil cytoplasmic antibodies (ANCA). A report on the second phase of an international cooperative study on the standardization of ANCA assays

Author

Hagen, Ernst Christiaan, Andrassy, Konrad, Csernok, Elena, Daha, Mohamed, Gaskin, Gill, Gross, W.L., Hansen, Bettina, Heigl, Z., Hermans, Julie, Jayne, David R.W.David, Kallenberg, Cees Gm, Lesavre, Philippe, Lockwood, Christopher Martin, Lüdemann, J., Mascart, Françoise, Mirapeix, Eduardo, Pusey, Charles Dickson, Rasmussen, Niels, Sinico, Renato A, Tzioufas, Athanasios, Wieslander, J., Wiik, Anna, van der Woude, Fokko J, Hagen, Ernst Christiaan, Andrassy, Konrad, Csernok, Elena, Daha, Mohamed, Gaskin, Gill, Gross, W.L., Hansen, Bettina, Heigl, Z., Hermans, Julie, Jayne, David R.W.David, Kallenberg, Cees Gm, Lesavre, Philippe, Lockwood, Christopher Martin, Lüdemann, J., Mascart, Françoise, Mirapeix, Eduardo, Pusey, Charles Dickson, Rasmussen, Niels, Sinico, Renato A, Tzioufas, Athanasios, Wieslander, J., Wiik, Anna, and van der Woude, Fokko J

Abstract

Anti-neutrophil cytoplasmic antibodies (ANCA) are diagnostic markers for systemic vasculitis. They are classically I detected by an indirect immunofluorescence test using normal donor neutrophils as substrate. This assay lacks antigenic specificity and is not quantitative. The 'EC/BCR Project for ANCA Assay Standardization' is an international collaboration study with the aim to develop and standardize solid phase assays for ANCA detection. In this part of the study the isolation and characterization of proteinase-3 and myeloperoxidase, the two main target molecules for ANCA, and the development and standardization of ELISAs with these antigens are described. Six laboratories successfully isolated purified proteinase-3 preparations that could be used. Three of these preparations, together with one myeloperoxidase preparation, were subsequently used for ANCA testing by ELISA. The ELISA technique was standardized in two rounds of testing in the 14 participating laboratories. The coefficient of variation of these new assays decreased from values of approx. 50% in the first round to approx. 20% in the second round. We conclude that purified proteinase-3 and myeloperoxidase can be used in standardized ELISAs for ANCA detection. Whether such procedures offer advantages over the IIF test will be determined in a prospective clinical study., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
1996

107. European therapeutic trials in ANCA-associated systemic vasculitis: Disease scoring, consensus regimens and proposed clinical trials EUROPEAN COMMUNITY STUDY GROUP ON CLINICAL TRIALS IN SYSTEMIC VASCULITIS ECSYSVASTRIAL (BMHl-Cr93-1078)

Author

Rasmussen, Niels, Jayne, David R.W.David, Lockwood, Christopher Martin, Abramowicz, Daniel, Andrassy, Konrad, Bacon, Paul P.A., Savage, Caroline, Cohen Tervaert, Jan J.W., Kallenberg, Cees Gm, Dadonlené, J., Feighery, Conleth, Van Es, Leendert L.A., Hermans, Jo, van der Woude, Fokko J, Ferrario, Franco, Sinico, Renato A, Gaskin, Gill, Pusey, Charles Dickson, Gregorini, Gina, De Groot, Kirsten, Gross, Wolfgang Ludwig, Gronhagen-Riska, Carola, Guillevin, Loïc, Hagen, Ernst Christiaan, Heigl, Z., Landais, Paul, Lesavre, Philippe, Luqmani, R., Mirapeix, Eduard, Pettersson, Erna, Specks, Ulrich, Tzioufas, Athanasios, Westman, Kerstin W A, Wiik, Allan, Rasmussen, Niels, Jayne, David R.W.David, Lockwood, Christopher Martin, Abramowicz, Daniel, Andrassy, Konrad, Bacon, Paul P.A., Savage, Caroline, Cohen Tervaert, Jan J.W., Kallenberg, Cees Gm, Dadonlené, J., Feighery, Conleth, Van Es, Leendert L.A., Hermans, Jo, van der Woude, Fokko J, Ferrario, Franco, Sinico, Renato A, Gaskin, Gill, Pusey, Charles Dickson, Gregorini, Gina, De Groot, Kirsten, Gross, Wolfgang Ludwig, Gronhagen-Riska, Carola, Guillevin, Loïc, Hagen, Ernst Christiaan, Heigl, Z., Landais, Paul, Lesavre, Philippe, Luqmani, R., Mirapeix, Eduard, Pettersson, Erna, Specks, Ulrich, Tzioufas, Athanasios, Westman, Kerstin W A, and Wiik, Allan

Abstract

SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published

Published
1995

108. Pathogenesis of Diabetic Nephropathy: Biochemical and Functional Alterations of Glomerular Basement Membrane and Mesangium.

Author

Yard, Benito A., van Det, Nicole F., and van der Woude, Fokko J.

Subjects
PEOPLE with diabetes, DIABETES complications, KIDNEY diseases, CYTOKINES, GLOMERULAR filtration rate, EPITHELIUM
Abstract

In patients with diabetic nephropathy (DN), the composition of the mesangium and glomerular basement membrane is changed. Accumulation of extracellular matrix proteins such as collagens, laminin, fibronectin and decreased expression of heparan sulphate proteoglycens (HSPG) are amongst other prominent characteristics that can be observed in DN. These changes are likely to be a result of a complex interplay of different factors like hyperglycaemia, the local production of angiotensin II and transforming growth factor-β. HSPG expression may directly contribute to mesangial expansion. In this chapter biochemical and functional alteration of the glomerular basement membrane and mesangium are discussed with emphasis on HSPG. [ABSTRACT FROM PUBLISHER]

Published
2001

137. Decreased frequency of HLA-DR13DR6 in Wegener's granulomatosis

Author

Hagen, E. Christiaan, primary, Stegeman, Coen A., additional, D'Amaro, Joe, additional, Schreuder, Geziena M.T., additional, Lems, Simon P.M., additional, Cohen Tervaert, Jan Willem, additional, de Jong, Gijs MTh, additional, Hené, Ronald J., additional, Kallenberg, Cees G.M., additional, Daha, Mohammed R., additional, and van der Woude, Fokko J., additional

Published
1995
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results