Author: "Van't Veer, Laura J." - Searchworks@Jio Institute Digital Library Search Results

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554 results on '"Van't Veer, Laura J."'

101. Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial

Author: Shieh, Yiwey, primary, Eklund, Martin, additional, Madlensky, Lisa, additional, Sawyer, Sarah D., additional, Thompson, Carlie K., additional, Stover Fiscalini, Allison, additional, Ziv, Elad, additional, van’t Veer, Laura J., additional, Esserman, Laura J., additional, and Tice, Jeffrey A., additional
Published: 2017
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102. Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

Author: Ju, Young Seok, Tubio, Jose MC, Mifsud, William, Fu, Beiyuan, Davies, Helen R, Ramakrishna, Manasa, Li, Yilong, Yates, Lucy, Gundem, Gunes, Tarpey, Patrick S, Behjati, Sam, Papaemmanuil, Elli, Martin, Sancha, Fullam, Anthony, Gerstung, Moritz, ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, ICGC Breast Cancer Working Group, Nangalia, Jyoti, Green, Anthony R, Caldas, Carlos, Borg, Åke, Tutt, Andrew, Lee, Ming Ta Michael, van't Veer, Laura J, Tan, Benita KT, Aparicio, Samuel, Span, Paul N, Martens, John WM, Knappskog, Stian, Vincent-Salomon, Anne, Børresen-Dale, Anne-Lise, Eyfjörd, Jórunn Erla, Myklebost, Ola, Flanagan, Adrienne M, Foster, Christopher, Neal, David E, Cooper, Colin, Eeles, Rosalind, Bova, Steven G, Lakhani, Sunil R, Desmedt, Christine, Thomas, Gilles, Richardson, Andrea L, Purdie, Colin A, Thompson, Alastair M, McDermott, Ultan, Yang, Fengtang, Nik-Zainal, Serena, Campbell, Peter J, and Stratton, Michael R
Subjects: DNA Replication, DNA End-Joining Repair, DNA Copy Number Variations, ICGC Prostate Cancer Working Group, Bioinformatics, 1.1 Normal biological development and functioning, Molecular Sequence Data, Medical and Health Sciences, Chromosomes, Fluorescence, Cell Line, ICGC Bone Cancer Working Group, Stem Cell Research - Nonembryonic - Human, Underpinning research, Neoplasms, Genetics, Humans, 2.1 Biological and endogenous factors, Amino Acid Sequence, Aetiology, In Situ Hybridization, Cancer, Cell Nucleus, Tumor, Genome, Human Genome, Reproducibility of Results, DNA, Biological Sciences, Stem Cell Research, Mitochondria, Mitochondrial, ICGC Breast Cancer Working Group, Hela Cells, Generic health relevance, Sequence Analysis, Human
Abstract: Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved. Remarkably, mitochondrial-nuclear genome fusions occur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the presence of a high frequency of contact between mitochondrial and nuclear DNA in some somatic cells. Transmission of mitochondrial DNA to the nuclear genome occurs in neoplastically transformed cells, but we do not exclude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years earlier in normal somatic cells.
Published: 2015

103. Association of Event-Free and Distant Recurrence–Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial

Author: Yee, Douglas, DeMichele, Angela M., Yau, Christina, Isaacs, Claudine, Symmans, W. Fraser, Albain, Kathy S., Chen, Yunn-Yi, Krings, Gregor, Wei, Shi, Harada, Shuko, Datnow, Brian, Fadare, Oluwole, Klein, Molly, Pambuccian, Stefan, Chen, Beiyun, Adamson, Kathi, Sams, Sharon, Mhawech-Fauceglia, Paulette, Magliocco, Anthony, Feldman, Mike, Rendi, Mara, Sattar, Husain, Zeck, Jay, Ocal, Idris T., Tawfik, Ossama, LeBeau, Lauren Grasso, Sahoo, Sunati, Vinh, Tuyethoa, Chien, A. Jo, Forero-Torres, Andres, Stringer-Reasor, Erica, Wallace, Anne M., Pusztai, Lajos, Boughey, Judy C., Ellis, Erin D., Elias, Anthony D., Lu, Janice, Lang, Julie E., Han, Hyo S., Clark, Amy S., Nanda, Rita, Northfelt, Donald W., Khan, Qamar J., Viscusi, Rebecca K., Euhus, David M., Edmiston, Kirsten K., Chui, Stephen Y., Kemmer, Kathleen, Park, John W., Liu, Minetta C., Olopade, Olufunmilayo, Leyland-Jones, Brian, Tripathy, Debasish, Moulder, Stacy L., Rugo, Hope S., Schwab, Richard, Lo, Shelly, Helsten, Teresa, Beckwith, Heather, Haugen, Patricia, Hylton, Nola M., van’t Veer, Laura J., Perlmutter, Jane, Melisko, Michelle E., Wilson, Amy, Peterson, Garry, Asare, Adam L., Buxton, Meredith B., Paoloni, Melissa, Clennell, Julia L., Hirst, Gillian L., Singhrao, Ruby, Steeg, Katherine, Matthews, Jeffrey B., Asare, Smita M., Sanil, Ashish, Berry, Scott M., Esserman, Laura J., and Berry, Donald A.
Abstract: IMPORTANCE: Pathologic complete response (pCR) is a known prognostic biomarker for long-term outcomes. The I-SPY2 trial evaluated if the strength of this clinical association persists in the context of a phase 2 neoadjuvant platform trial. OBJECTIVE: To evaluate the association of pCR with event-free survival (EFS) and pCR with distant recurrence–free survival (DRFS) in subpopulations of women with high-risk operable breast cancer treated with standard therapy or one of several novel agents. DESIGN, SETTING, AND PARTICIPANTS: Multicenter platform trial of women with operable clinical stage 2 or 3 breast cancer with no prior surgery or systemic therapy for breast cancer; primary tumors were 2.5 cm or larger. Women with tumors that were ERBB2 negative/hormone receptor (HR) positive with low 70-gene assay score were excluded. Participants were adaptively randomized to one of several different investigational regimens or control therapy within molecular subtypes from March 2010 through 2016. The analysis included participants with follow-up data available as of February 26, 2019. INTERVENTIONS: Standard-of-care neoadjuvant therapy consisting of taxane treatment with or without (as control) one of several investigational agents or combinations followed by doxorubicin and cyclophosphamide. MAIN OUTCOMES AND MEASURES: Pathologic complete response and 3-year EFS and DRFS. RESULTS: Of the 950 participants (median [range] age, 49 [23-77] years), 330 (34.7%) achieved pCR. Three-year EFS and DRFS for patients who achieved pCR were both 95%. Hazard ratios for pCR vs non-pCR were 0.19 for EFS (95% CI, 0.12-0.31) and 0.21 for DRFS (95% CI, 0.13-0.34) and were similar across molecular subtypes, varying from 0.14 to 0.18 for EFS and 0.10 to 0.20 for DRFS. CONCLUSIONS AND RELEVANCE: The 3-year outcomes from the I-SPY2 trial show that, regardless of subtype and/or treatment regimen, including 9 novel therapeutic combinations, achieving pCR after neoadjuvant therapy implies approximately an 80% reduction in recurrence rate. The goal of the I-SPY2 trial is to rapidly identify investigational therapies that may improve pCR when validated in a phase 3 confirmatory trial. Whether pCR is a validated surrogate in the sense that a therapy that improves pCR rate can be assumed to also improve long-term outcome requires further study. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01042379
Published: 2020
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104. Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2

Author: Orr, Nick, Dudbridge, Frank, Dryden, Nicola, Maguire, Sarah, Novo, Daniela, Perrakis, Eleni, Johnson, Nichola, Ghoussaini, Maya, Hopper, John L., Southey, Melissa C., Apicella, Carmel, Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Hogervorst, Frans B., Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Gibson, Lorna, Aitken, Zoe, Warren, Helen, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Chistof, Guenel, Pascal, Truong, Therese, Cordina-Duverger, Emilie, Sanchez, Marie, Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Zamora, Maria Pilar, Arias Perez, Jose Ignacio, Menendez, Primitiva, Anton-Culver, Hoda, Neuhausen, Susan L., Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, and Hamann, Ute et al.
Subjects: ddc
Published: 2014

105. 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer.

Author: UCL - Autre, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'oncologie médicale, Cardoso, Fatima, van't Veer, Laura J, Bogaerts, Jan, Slaets, Leen, Viale, Giuseppe, Delaloge, Suzette, Pierga, Jean-Yves, Brain, Etienne, Causeret, Sylvain, DeLorenzi, Mauro, Glas, Annuska M, Golfinopoulos, Vassilis, Goulioti, Theodora, Knox, Susan, Matos, Erika, Meulemans, Bart, Neijenhuis, Peter A, Nitz, Ulrike, Passalacqua, Rodolfo, Ravdin, Peter, Rubio, Isabel T, Saghatchian, Mahasti, Smilde, Tineke J, Sotiriou, Christos, Stork, Lisette, Straehle, Carolyn, Thomas, Geraldine, Thompson, Alastair M, van der Hoeven, Jacobus M, Vuylsteke, Peter, Bernards, René, Tryfonidis, Konstantinos, Rutgers, Emiel, Piccart, Martine, MINDACT Investigators, UCL - Autre, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'oncologie médicale, Cardoso, Fatima, van't Veer, Laura J, Bogaerts, Jan, Slaets, Leen, Viale, Giuseppe, Delaloge, Suzette, Pierga, Jean-Yves, Brain, Etienne, Causeret, Sylvain, DeLorenzi, Mauro, Glas, Annuska M, Golfinopoulos, Vassilis, Goulioti, Theodora, Knox, Susan, Matos, Erika, Meulemans, Bart, Neijenhuis, Peter A, Nitz, Ulrike, Passalacqua, Rodolfo, Ravdin, Peter, Rubio, Isabel T, Saghatchian, Mahasti, Smilde, Tineke J, Sotiriou, Christos, Stork, Lisette, Straehle, Carolyn, Thomas, Geraldine, Thompson, Alastair M, van der Hoeven, Jacobus M, Vuylsteke, Peter, Bernards, René, Tryfonidis, Konstantinos, Rutgers, Emiel, Piccart, Martine, and MINDACT Investigators
Abstract: BACKGROUND: The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. We sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical-pathological criteria in selecting patients for adjuvant chemotherapy. METHODS: In this randomized, phase 3 study, we enrolled 6693 women with early-stage breast cancer and determined their genomic risk (using the 70-gene signature) and their clinical risk (using a modified version of Adjuvant! Online). Women at low clinical and genomic risk did not receive chemotherapy, whereas those at high clinical and genomic risk did receive such therapy. In patients with discordant risk results, either the genomic risk or the clinical risk was used to determine the use of chemotherapy. The primary goal was to assess whether, among patients with high-risk clinical features and a low-risk gene-expression profile who did not receive chemotherapy, the lower boundary of the 95% confidence interval for the rate of 5-year survival without distant metastasis would be 92% (i.e., the noninferiority boundary) or higher. RESULTS: A total of 1550 patients (23.2%) were deemed to be at high clinical risk and low genomic risk. At 5 years, the rate of survival without distant metastasis in this group was 94.7% (95% confidence interval, 92.5 to 96.2) among those not receiving chemotherapy. The absolute difference in this survival rate between these patients and those who received chemotherapy was 1.5 percentage points, with the rate being lower without chemotherapy. Similar rates of survival without distant metastasis were reported in the subgroup of patients who had estrogen-receptor-positive, human epidermal growth factor receptor 2-negative, and either node-negative or node-positive disease. CONCLUSIONS: Among women with early-stage breast cancer who were at high clinical risk and low genomic risk for recurrence, the r
Published: 2016

106. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

Author: University of Helsinki, Medicum, University of Helsinki, Clinicum, University of Helsinki, Department of Pathology, University of Helsinki, Department of Obstetrics and Gynecology, Lawrenson, Kate, Kar, Siddhartha, McCue, Karen, Kuchenbaeker, Karoline, Michailidou, Kyriaki, Tyrer, Jonathan, Beesley, Jonathan, Ramus, Susan J., Li, Qiyuan, Delgado, Melissa K., Lee, Janet M., Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Arun, Banu K., Arver, Brita, Bandera, Elisa V., Barile, Monica, Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Benitez, Javier, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Blomqvist, Carl, Blot, William, Bogdanova, Natalia, Bojesen, Anders, Bojesen, Stig E., Bolla, Manjeet K., Bonanni, Bernardo, Borresen-Dale, Anne-Lise, Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Bruinsma, Fiona, Brunet, Joan, Buhari, Shaik Ahmad, Burwinkel, Barbara, Butzow, Ralf, Buys, Saundra S., Cai, Qiuyin, Caldes, Trinidad, Campbell, Ian, Canniotto, Rikki, Chang-Claude, Jenny, Chiquette, Jocelyne, Choi, Ji-Yeob, Claes, Kathleen B. M., Cook, Linda S., Cox, Angela, Cramer, Daniel W., Cross, Simon S., Cybulski, Cezary, Czene, Kamila, Daly, Mary B., Damiola, Francesca, Dansonka-Mieszkowska, Agnieszka, Darabi, Hatef, Dennis, Joe, Devilee, Peter, Diez, Orland, Doherty, Jennifer A., Domchek, Susan M., Dorfling, Cecilia M., Doerk, Thilo, Dumont, Martine, Ehrencrona, Hans, Ejlertsen, Bent, Ellis, Steve, Engel, Christoph, Lee, Eunjung, Evans, D. Gareth, Fasching, Peter A., Feliubadalo, Lidia, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Foretova, Lenka, Fostira, Florentia, Foulkes, William D., Fridley, Brooke L., Friedman, Eitan, Frost, Debra, Gambino, Gaetana, Ganz, Patricia A., Garber, Judy, Garcia-Closas, Montserrat, Gentry-Maharaj, Aleksandra, Ghoussaini, Maya, Giles, Graham G., Glasspool, Rosalind, Godwin, Andrew K., Goldberg, Mark S., Goldgar, David E., Gonzalez-Neira, Anna, Goode, Ellen L., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, Guenel, Pascal, Haiman, Christopher A., Hall, Per, Hallberg, Emily, Hamann, Ute, Hansen, Thomas V. O., Harrington, Patricia A., Hartman, Mikael, Hassan, Norhashimah, Healey, Sue, Heitz, Florian, Herzog, Josef, Hogdall, Estrid, Hogdall, Claus K., Hogervorst, Frans B. L., Hollestelle, Antoinette, Hopper, John L., Hulick, Peter J., Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Ito, Hidemi, Jakubowska, Anna, Janavicius, Ramunas, Jensen, Allan, John, Esther M., Johnson, Nichola, Kabisch, Maria, Kang, Daehee, Kapuscinski, Miroslav, Karlan, Beth Y., Khan, Sofia, Kiemeney, Lambertus A., Kjaer, Susanne Kruger, Knight, Julia A., Konstantopoulou, Irene, Kosma, Veli-Matti, Kristensen, Vessela, Kupryjanczyk, Jolanta, Kwong, Ava, de la Hoya, Miguel, Laitman, Yael, Lambrechts, Diether, Le, Nhu, De Leeneer, Kim, Lester, Jenny, Levine, Douglas A., Li, Jingmei, Lindblom, Annika, Long, Jirong, Lophatananon, Artitaya, Loud, Jennifer T., Lu, Karen, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Le Marchand, Loic, Margolin, Sara, Marme, Frederik, Massuger, Leon F. A. G., Matsuo, Keitaro, Mazoyer, Sylvie, McGuffog, Lesley, McLean, Catriona, McNeish, Iain, Meindl, Alfons, Menon, Usha, Mensenkamp, Arjen R., Milne, Roger L., Montagna, Marco, Moysich, Kirsten B., Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L., Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Nord, Silje, Nussbaum, Robert L., Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Olson, Janet E., Olswold, Curtis, O'Malley, David, Orlow, Irene, Orr, Nick, Osorio, Ana, Park, Sue Kyung, Pearce, Celeste L., Pejovic, Tanja, Peterlongo, Paolo, Pfeiler, Georg, Phelan, Catherine M., Poole, Elizabeth M., Pylkas, Katri, Radice, Paolo, Rantala, Johanna, Rashid, Muhammad Usman, Rennert, Gad, Rhenius, Valerie, Rhiem, Kerstin, Risch, Harvey A., Rodriguez, Gus, Rossing, Mary Anne, Rudolph, Anja, Salvesen, Helga B., Sangrajrang, Suleeporn, Sawyer, Elinor J., Schildkraut, Joellen M., Schmidt, Marjanka K., Schmutzler, Rita K., Sellers, Thomas A., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Sieh, Weiva, Singer, Christian F., Sinilnikova, Olga M., Slager, Susan, Song, Honglin, Soucy, Penny, Southey, Melissa C., Stenmark-Askmalm, Marie, Stoppa-Lyonnet, Dominique, Sutter, Christian, Swerdlow, Anthony, Tchatchou, Sandrine, Teixeira, Manuel R., Teo, Soo H., Terry, Kathryn L., Terry, Mary Beth, Thomassen, Mads, Tibiletti, Maria Grazia, Tihomirova, Laima, Tognazzo, Silvia, Toland, Amanda Ewart, Tomlinson, Ian, Torres, Diana, Truong, Therese, Tseng, Chiu-chen, Tung, Nadine, Tworoger, Shelley S., Vachon, Celine, van den Ouweland, Ans M. W., van Doorn, Helena C., van Rensburg, Elizabeth J., Van't Veer, Laura J., Vanderstichele, Adriaan, Vergote, Ignace, Vijai, Joseph, Wang, Qin, Wang-Gohrke, Shan, Weitzel, Jeffrey N., Wentzensen, Nicolas, Whittemore, Alice S., Wildiers, Hans, Winqvist, Robert, Wu, Anna H., Yannoukakos, Drakoulis, Yoon, Sook-Yee, Yu, Jyh-Cherng, Zheng, Wei, Zheng, Ying, Khanna, Kum Kum, Simard, Jacques, Monteiro, Alvaro N., French, Juliet D., Couch, Fergus J., Freedman, Matthew L., Easton, Douglas F., Dunning, Alison M., Pharoah, Paul D., Edwards, Stacey L., Chenevix-Trench, Georgia, Antoniou, Antonis C., Gayther, Simon A., GEMO Study Collaborators, EMBRACE, Hereditary Breast & Ovarian Canc R, KConFab Investigators, Australian Ovarian Canc Study Grp, University of Helsinki, Medicum, University of Helsinki, Clinicum, University of Helsinki, Department of Pathology, University of Helsinki, Department of Obstetrics and Gynecology, Lawrenson, Kate, Kar, Siddhartha, McCue, Karen, Kuchenbaeker, Karoline, Michailidou, Kyriaki, Tyrer, Jonathan, Beesley, Jonathan, Ramus, Susan J., Li, Qiyuan, Delgado, Melissa K., Lee, Janet M., Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Arun, Banu K., Arver, Brita, Bandera, Elisa V., Barile, Monica, Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Benitez, Javier, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Blomqvist, Carl, Blot, William, Bogdanova, Natalia, Bojesen, Anders, Bojesen, Stig E., Bolla, Manjeet K., Bonanni, Bernardo, Borresen-Dale, Anne-Lise, Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Bruinsma, Fiona, Brunet, Joan, Buhari, Shaik Ahmad, Burwinkel, Barbara, Butzow, Ralf, Buys, Saundra S., Cai, Qiuyin, Caldes, Trinidad, Campbell, Ian, Canniotto, Rikki, Chang-Claude, Jenny, Chiquette, Jocelyne, Choi, Ji-Yeob, Claes, Kathleen B. M., Cook, Linda S., Cox, Angela, Cramer, Daniel W., Cross, Simon S., Cybulski, Cezary, Czene, Kamila, Daly, Mary B., Damiola, Francesca, Dansonka-Mieszkowska, Agnieszka, Darabi, Hatef, Dennis, Joe, Devilee, Peter, Diez, Orland, Doherty, Jennifer A., Domchek, Susan M., Dorfling, Cecilia M., Doerk, Thilo, Dumont, Martine, Ehrencrona, Hans, Ejlertsen, Bent, Ellis, Steve, Engel, Christoph, Lee, Eunjung, Evans, D. Gareth, Fasching, Peter A., Feliubadalo, Lidia, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Foretova, Lenka, Fostira, Florentia, Foulkes, William D., Fridley, Brooke L., Friedman, Eitan, Frost, Debra, Gambino, Gaetana, Ganz, Patricia A., Garber, Judy, Garcia-Closas, Montserrat, Gentry-Maharaj, Aleksandra, Ghoussaini, Maya, Giles, Graham G., Glasspool, Rosalind, Godwin, Andrew K., Goldberg, Mark S., Goldgar, David E., Gonzalez-Neira, Anna, Goode, Ellen L., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, Guenel, Pascal, Haiman, Christopher A., Hall, Per, Hallberg, Emily, Hamann, Ute, Hansen, Thomas V. O., Harrington, Patricia A., Hartman, Mikael, Hassan, Norhashimah, Healey, Sue, Heitz, Florian, Herzog, Josef, Hogdall, Estrid, Hogdall, Claus K., Hogervorst, Frans B. L., Hollestelle, Antoinette, Hopper, John L., Hulick, Peter J., Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Ito, Hidemi, Jakubowska, Anna, Janavicius, Ramunas, Jensen, Allan, John, Esther M., Johnson, Nichola, Kabisch, Maria, Kang, Daehee, Kapuscinski, Miroslav, Karlan, Beth Y., Khan, Sofia, Kiemeney, Lambertus A., Kjaer, Susanne Kruger, Knight, Julia A., Konstantopoulou, Irene, Kosma, Veli-Matti, Kristensen, Vessela, Kupryjanczyk, Jolanta, Kwong, Ava, de la Hoya, Miguel, Laitman, Yael, Lambrechts, Diether, Le, Nhu, De Leeneer, Kim, Lester, Jenny, Levine, Douglas A., Li, Jingmei, Lindblom, Annika, Long, Jirong, Lophatananon, Artitaya, Loud, Jennifer T., Lu, Karen, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Le Marchand, Loic, Margolin, Sara, Marme, Frederik, Massuger, Leon F. A. G., Matsuo, Keitaro, Mazoyer, Sylvie, McGuffog, Lesley, McLean, Catriona, McNeish, Iain, Meindl, Alfons, Menon, Usha, Mensenkamp, Arjen R., Milne, Roger L., Montagna, Marco, Moysich, Kirsten B., Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L., Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Nord, Silje, Nussbaum, Robert L., Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Olson, Janet E., Olswold, Curtis, O'Malley, David, Orlow, Irene, Orr, Nick, Osorio, Ana, Park, Sue Kyung, Pearce, Celeste L., Pejovic, Tanja, Peterlongo, Paolo, Pfeiler, Georg, Phelan, Catherine M., Poole, Elizabeth M., Pylkas, Katri, Radice, Paolo, Rantala, Johanna, Rashid, Muhammad Usman, Rennert, Gad, Rhenius, Valerie, Rhiem, Kerstin, Risch, Harvey A., Rodriguez, Gus, Rossing, Mary Anne, Rudolph, Anja, Salvesen, Helga B., Sangrajrang, Suleeporn, Sawyer, Elinor J., Schildkraut, Joellen M., Schmidt, Marjanka K., Schmutzler, Rita K., Sellers, Thomas A., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Sieh, Weiva, Singer, Christian F., Sinilnikova, Olga M., Slager, Susan, Song, Honglin, Soucy, Penny, Southey, Melissa C., Stenmark-Askmalm, Marie, Stoppa-Lyonnet, Dominique, Sutter, Christian, Swerdlow, Anthony, Tchatchou, Sandrine, Teixeira, Manuel R., Teo, Soo H., Terry, Kathryn L., Terry, Mary Beth, Thomassen, Mads, Tibiletti, Maria Grazia, Tihomirova, Laima, Tognazzo, Silvia, Toland, Amanda Ewart, Tomlinson, Ian, Torres, Diana, Truong, Therese, Tseng, Chiu-chen, Tung, Nadine, Tworoger, Shelley S., Vachon, Celine, van den Ouweland, Ans M. W., van Doorn, Helena C., van Rensburg, Elizabeth J., Van't Veer, Laura J., Vanderstichele, Adriaan, Vergote, Ignace, Vijai, Joseph, Wang, Qin, Wang-Gohrke, Shan, Weitzel, Jeffrey N., Wentzensen, Nicolas, Whittemore, Alice S., Wildiers, Hans, Winqvist, Robert, Wu, Anna H., Yannoukakos, Drakoulis, Yoon, Sook-Yee, Yu, Jyh-Cherng, Zheng, Wei, Zheng, Ying, Khanna, Kum Kum, Simard, Jacques, Monteiro, Alvaro N., French, Juliet D., Couch, Fergus J., Freedman, Matthew L., Easton, Douglas F., Dunning, Alison M., Pharoah, Paul D., Edwards, Stacey L., Chenevix-Trench, Georgia, Antoniou, Antonis C., Gayther, Simon A., GEMO Study Collaborators, EMBRACE, Hereditary Breast & Ovarian Canc R, KConFab Investigators, and Australian Ovarian Canc Study Grp
Abstract: A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P = 9.2 x 10(-20)), ER-negative BC (P = 1.1 x 10(-13)), BRCA1-associated BC (P = 7.7 x 10(-16)) and triple negative BC (P-diff = 2 x 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P = 2 x 10(-3)) and ABHD8 (P
Published: 2016

107. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

Author: Hoadley, Katherine A., Yau, Christina, Wolf, Denise M., Cherniack, Andrew D., Tamborero, David, Sam, Ng, Leiserson, Max D. M., Niu, Beifang, Mclellan, Michael D., Uzunangelov, Vladislav, Zhang, Jiashan, Kandoth, Cyriac, Akbani, Rehan, Shen, Hui, Omberg, Larsson, Chu, Andy, Margolin, Adam A., Van'T Veer, Laura J., Lopez Bigas, Nuria, Laird, Peter W., Raphael, Benjamin J., Ding, Li, Robertson, A. Gordon, Byers, Lauren A., Mills, Gordon B., Weinstein, John N., Van Waes, Carter, Chen, Zhong, Collisson, Eric A., Benz, Christopher C, Perou, Charles M., Stuart, Joshua M., Rachel, Abbott, Scott, Abbott, Arman Aksoy, B., Kenneth, Aldape, Adrian, Ally, Samirku mar Amin, Dimitris, Anastassiou, Todd Auman, J., Baggerly, Keith A., Miruna, Balasundaram, Saianand, Balu, Baylin, Stephen B., Benz, Stephen C., Berman, Benjamin P., Brady, Bernard, Bhatt, Ami S., Inanc, Birol, Black, Aaron D., Tom, Bodenheimer, Bootwalla, Moiz S., Jay, Bowen, Ryan, Bressler, Bristow, Christopher A., Brooks, Angela N., Bradley, Broom, Elizabeth, Buda, Robert, Burton, Butterfield, Yaron S. N., Daniel, Carlin, Carter, Scott L., Casasent, Tod D., Kyle, Chang, Stephen, Chanock, Lynda, Chin, Dong Yeon Cho, Juok, Cho, Eric, Chuah, Chun, Hye Jung E., Kristian, Cibulskis, Giovanni, Ciriello, James Cle land, Melisssa, Cline, Brian, Craft, Creighton, Chad J., Ludmila, Danilova, Tanja, Davidsen, Caleb, Davis, Dees, Nathan D., Kim, Delehaunty, Demchok, John A., Noreen, Dhalla, Daniel, Dicara, Huyen, Dinh, Dobson, Jason R., Deepti, Dodda, Harshavardhan, Doddapaneni, Lawrence, Donehower, Dooling, David J., Gideon, Dresdner, Jennifer, Drummond, Andrea, Eakin, Mary, Edgerton, Eldred, Jim M., Greg, Eley, Kyle, Ellrott, Cheng, Fan, Suzanne, Fei, Ina, Felau, Scott, Frazer, Freeman, Samuel S., Jessica, Frick, Fronick, Catrina C., Ful ton, Lucinda L., Robert, Fulton, Gabriel, Stacey B., Jianjiong, Gao, Gastier Foster, Julie M., Nils, Gehlenborg, Myra, George, Gad, Getz, Richard, Gibbs, Mary, Goldman, Abel Gonzalez Perez, Benjamin, Gross, Ranabir, Guin, Preethi, Gunaratne, Angela, Hadjipanayis, Hamilton, Mark P., Hamilton, Stanley R., Leng, Han, Han, Yi, Harper, Hollie A., Psalm, Haseley, David, Haussler, Neil Hayes, D., Heiman, David I., Elena, Helman, Carmen, Helsel, Herbrich, Shelley M., Her man, James G., Toshinori, Hinoue, Carrie, Hirst, Martin, Hirst, Holt, Robert A., Hoyle, Alan P., Lisa, Iype, Anders, Jacobsen, Jeffreys, Stuart R., Jensen, Mark A., Jones, Corbin D., Jones, Steven J. M., Zhenlin, Ju, Joonil, Jung, Andre, Kahles, Ari, Kahn, Joelle Kalicki Veizer, Divya, Kalra, Krishna Latha Kanchi, Kane, David W., Hoon, Kim, Jaegil, Kim, Theo, Knijnenburg, Koboldt, Daniel C., Christie, Kovar, Roger, Kramer, Richard, Kreisberg, Raju, Kucherlapati, Marc, Ladanyi, Lander, Eric S., Larson, David E., Lawrence, Michael S., Darlene, Lee, Eunjung, Lee, Semin, Lee, William, Lee, Kjong Van Lehmann, Kalle, Leinonen, Ler aas, Kristen M., Seth, Lerner, Levine, Douglas A., Lora, Lewis, Ley, Timothy J., Haiyan I., Li, Jun, Li, Wei, Li, Han, Liang, Lichtenberg, Tara M., Jake, Lin, Ling, Lin, Pei, Lin, Wen bin Liu, Yingchun, Liu, Yuexin, Liu, Lorenzi, Philip L., Charles, Lu, Yiling, Lu, Luquette, Love lace J., Singer, Ma, Magrini, Vincent J., Mahadeshwar, Harshad S., Mardis, Elaine R., Adam, Margolin, Marra, Marco A., Michael, Mayo, Cynthia, Mcallister, Mcguire, Sean E., Mcmichael, Joshua F., James, Melott, Shaowu, Meng, Matthew, Meyerson, Mieczkowski, Piotr A., Miller, Christopher A., Miller, Martin L., Michael, Miller, Moore, Richard A., Margaret, Morgan, Donna, Morton, Mose, Lisle E., Mungall, Andrew J., Donna, Muzny, Lam, Nguyen, Noble, Michael S., Houtan, Noushmehr, Michelle, O’Laughlin, Ojesina, Akinyemi I., Tai Hsien Ou Yang, Brad, Ozenberger, Angeliki, Pantazi, Michael, Parfenov, Park, Peter J., Parker, Joel S., Evan, Paull, Chandra Sekhar Pedamallu, Todd, Pihl, Craig, Pohl, David, Pot, Alexei, Protopopov, Teresa, Przytycka, Amie Raden baugh, Ramirez, Nilsa C., Ricardo, Ramirez, Gunnar Ra, ̈ tsch, Jeffrey, Reid, Xiao jia Ren, Boris, Reva, Reynolds, Sheila M., Rhie, Suhn K., Jeffrey, Roach, Hector, Rovira, Michael, Ryan, Gordon, Saksena, Sofie, Salama, Chris, Sander, Netty, Santoso, Schein, Jacqueline E., Heather, Schmidt, Nikolaus, Schultz, Schumacher, Steven E., Jonathan, Seidman, Yasin, Senbabaoglu, Sahil, Seth, Saman tha Sharpe, Ronglai, Shen, Margi, Sheth, Yan, Shi, Ilya, Shmulevich, Silva, Grace O., Simons, Janae V., Rileen, Sinha, Payal, Sipahimalani, Smith, Scott M., Sofia, Heidi J., Artem, Sokolov, Soloway, Mathew G., Xingzhi, Song, Carrie Soug nez, Paul, Spellman, Louis, Staudt, Chip, Stewart, Petar, Stojanov, Xiaoping, Su, Onur Sumer, S., Yichao, Sun, Teresa, Swatloski, Barbara, Tabak, Angela, Tam, Donghui, Tan, Jiabin, Tang, Roy, Tarnuzzer, Taylor, Barry S., Nina, Thiessen, Ves teinn Thorsson, Timothy Triche, J. r., Van Den Berg, David J., Vandin, Fabio, Varhol, Richard J., Vaske, Charles J., Umadevi, Veluvolu, Roeland, Verhaak, Doug, Voet, Jason, Walker, Wallis, John W., Peter, Waltman, Yunhu, Wan, Min, Wang, Wenyi, Wang, Zhining, Wang, Scot, Waring, Nils, Weinhold, Weisenberger, Daniel J., Wendl, Michael C., David, Wheeler, Wilkerson, Matthew D., Wilson, Richard K., Lisa, Wise, Andrew, Wong, Chang Jiun Wu, Chia Chin Wu, Hsin Ta Wu, Junyuan, Wu, Todd, Wylie, Liu, Xi, Ruibin, Xi, Zheng, Xia, Andrew W., Xu, Yang, Da, Liming, Yang, Lixing, Yang, Yang, Yang, Jun, Yao, Rong, Yao, Kai, Ye, Ko suke Yoshihara, Yuan, Yuan, Yung, Alfred K., Travis, Zack, Dong, Zeng, Jean Claude Zenklusen, Hailei, Zhang, Jianhua, Zhang, Nianxiang, Zhang, Qunyuan, Zhang, Wei, Zhang, Wei, Zhao, Siyuan, Zheng, Jing, Zhu, Erik, Zmuda, and Lihua, Zou
Subjects: Genetics and Molecular Biology (all), Cluster Analysis, Humans, Neoplasms, Transcriptome, Biochemistry, Genetics and Molecular Biology (all), Extramural, Biochemistry, Genetics and Molecular Biology(all), Cancer, Computational biology, Disease, Biology, medicine.disease, Bioinformatics, Biochemistry, General Biochemistry, Genetics and Molecular Biology, Article, 3. Good health, Molecular classification, TP63, CLUSTERS (ANÁLISE), medicine, Head and neck, Gene
Abstract: Summary Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.
Published: 2014

108. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

Author: Hoadley, Katherine A, Yau, Christina, Wolf, Denise M, Cherniack, Andrew D, Tamborero, David, Ng, Sam, Leiserson, Max DM, Niu, Beifang, McLellan, Michael D, Uzunangelov, Vladislav, Zhang, Jiashan, Kandoth, Cyriac, Akbani, Rehan, Shen, Hui, Omberg, Larsson, Chu, Andy, Margolin, Adam A, Van't Veer, Laura J, Lopez-Bigas, Nuria, Laird, Peter W, Raphael, Benjamin J, Ding, Li, Robertson, A Gordon, Byers, Lauren A, Mills, Gordon B, Weinstein, John N, Van Waes, Carter, Chen, Zhong, Collisson, Eric A, Cancer Genome Atlas Research Network, Benz, Christopher C, Perou, Charles M, and Stuart, Joshua M
Subjects: Urologic Diseases, Human Genome, Cancer Genome Atlas Research Network, Biological Sciences, Medical and Health Sciences, Rare Diseases, Neoplasms, Genetics, Humans, Cluster Analysis, 2.1 Biological and endogenous factors, Aetiology, Transcriptome, Biotechnology, Cancer, Developmental Biology
Abstract: Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. Weperformed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lungsquamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.
Published: 2014

109. 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

Author: Cardoso, Fatima, primary, van’t Veer, Laura J., additional, Bogaerts, Jan, additional, Slaets, Leen, additional, Viale, Giuseppe, additional, Delaloge, Suzette, additional, Pierga, Jean-Yves, additional, Brain, Etienne, additional, Causeret, Sylvain, additional, DeLorenzi, Mauro, additional, Glas, Annuska M., additional, Golfinopoulos, Vassilis, additional, Goulioti, Theodora, additional, Knox, Susan, additional, Matos, Erika, additional, Meulemans, Bart, additional, Neijenhuis, Peter A., additional, Nitz, Ulrike, additional, Passalacqua, Rodolfo, additional, Ravdin, Peter, additional, Rubio, Isabel T., additional, Saghatchian, Mahasti, additional, Smilde, Tineke J., additional, Sotiriou, Christos, additional, Stork, Lisette, additional, Straehle, Carolyn, additional, Thomas, Geraldine, additional, Thompson, Alastair M., additional, van der Hoeven, Jacobus M., additional, Vuylsteke, Peter, additional, Bernards, René, additional, Tryfonidis, Konstantinos, additional, Rutgers, Emiel, additional, and Piccart, Martine, additional
Published: 2016
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110. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

Author: Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., Cox, Angela, Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., and Cox, Angela
Published: 2015

111. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

Author: Genetica Sectie Genoomdiagnostiek, Cancer, Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., Cox, Angela, Genetica Sectie Genoomdiagnostiek, Cancer, Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., and Cox, Angela
Published: 2015

112. Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

Author: HASH(0x55d9c597d180), Ju, Young Seok, Tubio, Jose M C, Mifsud, William, Fu, Beiyuan, Davies, Helen R, Ramakrishna, Manasa, Li, Yilong, Yates, Lucy, Gundem, Gunes, Tarpey, Patrick S, Behjati, Sam, Papaemmanuil, Elli, Martin, Sancha, Fullam, Anthony, Gerstung, Moritz, Nangalia, Jyoti, Green, Anthony R, Caldas, Carlos, Borg, Åke, Tutt, Andrew, Lee, Ming Ta Michael, Van't Veer, Laura J, Tan, Benita K T, Aparicio, Samuel, Span, Paul N, Martens, John W M, Knappskog, Stian, Vincent-Salomon, Anne, Børresen-Dale, Anne-Lise, Eyfjörd, Jórunn Erla, Flanagan, Adrienne M, Foster, Christopher, Neal, David E, Cooper, Colin, Eeles, Rosalind, Lakhani, Sunil R, Desmedt, Christine, Thomas, Gilles, Richardson, Andrea L, Purdie, Colin A, Thompson, Alastair M, McDermott, Ultan, Yang, Fengtang, Nik-Zainal, Serena, Campbell, Peter J, Stratton, Michael R, ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, ICGC Breast Cancer Working Group, HASH(0x55d9c597d180), Ju, Young Seok, Tubio, Jose M C, Mifsud, William, Fu, Beiyuan, Davies, Helen R, Ramakrishna, Manasa, Li, Yilong, Yates, Lucy, Gundem, Gunes, Tarpey, Patrick S, Behjati, Sam, Papaemmanuil, Elli, Martin, Sancha, Fullam, Anthony, Gerstung, Moritz, Nangalia, Jyoti, Green, Anthony R, Caldas, Carlos, Borg, Åke, Tutt, Andrew, Lee, Ming Ta Michael, Van't Veer, Laura J, Tan, Benita K T, Aparicio, Samuel, Span, Paul N, Martens, John W M, Knappskog, Stian, Vincent-Salomon, Anne, Børresen-Dale, Anne-Lise, Eyfjörd, Jórunn Erla, Flanagan, Adrienne M, Foster, Christopher, Neal, David E, Cooper, Colin, Eeles, Rosalind, Lakhani, Sunil R, Desmedt, Christine, Thomas, Gilles, Richardson, Andrea L, Purdie, Colin A, Thompson, Alastair M, McDermott, Ultan, Yang, Fengtang, Nik-Zainal, Serena, Campbell, Peter J, Stratton, Michael R, ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, and ICGC Breast Cancer Working Group
Abstract: Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved. Remarkably, mitochondrial-nuclear genome fusions occur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the presence of a high frequency of contact between mitochondrial and nuclear DNA in some somatic cells. Transmission of mitochondrial DNA to the nuclear genome occurs in neoplastically transformed cells, but we do not exclude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years earlier in normal somatic cells.
Published: 2015

113. A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences

Author: Mittempergher, Lorenza, Saghatchian, Mahasti, Wolf, Denise M, Michiels, Stefan, Canisius, Sander, Dessen, Philippe, Delaloge, Suzette, Lazar, Vladimir, Benz, Stephen C, Tursz, Thomas, Bernards, René, and van't Veer, Laura J
Subjects: Microenvironment, Oncology and Carcinogenesis, Breast Neoplasms, Prognostic, Breast cancer, Breast Cancer, Genetics, Humans, 2.1 Biological and endogenous factors, Oncology & Carcinogenesis, Aetiology, Cancer, screening and diagnosis, MammaPrint, Gene Expression Profiling, Middle Aged, Gene expression profiling, Late distant metastasis, 4.1 Discovery and preclinical testing of markers and technologies, PARADIGM, Detection, Neoplasm Recurrence, Local, Lymphatic Metastasis, CH25H gene, Female, 4.2 Evaluation of markers and technologies
Abstract: IntroductionBreast cancer risk of recurrence is known to span 20 years, yet existing prognostic signatures are best at predicting early recurrences (≤ 5 years). There is a critical need to identify those patients at risk of late-relapse (>5 years), in order to select potential candidates for further treatment and to identify molecular targets for such treatment.MethodsA total of 252 breast primary tumors were selected at the Netherlands Cancer Institute from a retrospective series of ER+, HER2- breast cancer patients with a follow-up of at least 10 years. Gene expression analysis was performed using Agilent 4x44K microarrays. Patients were classified in 3 groups: no relapse (M0); relapse before 5 years (M0-5) or after 5 years (M5-15). We assessed the correlation of clinico-pathological variables with late Distant Metastases (DM). We divided the patient series into a training set of untreated patients (n = 140) and a test set of treated patients (n = 112), to investigate whether a gene-signature or single genes could be identified for predicting late DM. Pathway level late DM correlates were identified using PARADIGM and DAVID.ResultsOf the clinico-pathologic variables tested, only lymph node status associated with late DM. A 241-gene signature developed on the NKI training set was able to classify M5-15 patients in the test set with a sensitivity of 77% and a specificity of 33% (AUC 0.654). This signature showed enrichment in genes involved in immune response and extracellular matrix. An alternative analysis of individual genes identified CH25H as an independent predictor of distant metastasis in our patient series.ConclusionsWe identified a gene signature for late metastasis in breast cancer. Our data are consistent with a model in which suppressed anti-tumoral immunity enables dormant tumor cells to re-enter the cell cycle to form metastases in response to extrinsic events in the microenvironment.
Published: 2013

114. Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer.

Author: Lindström, Linda S., Yau, Christina, Czene, Kamila, Thompson, Carlie K., Hoadley, Katherine A., van't Veer, Laura J., Balassanian, Ron, Bishop, John W., Carpenter, Philip M., Yunn-Yi Chen, Datnow, Brian, Hasteh, Farnaz, Krings, Gregor, Lin, Fritz, Yanhong Zhang, Nordenskjöld, Bo, Stål, Olle, Benz, Christopher C., Fornander, Tommy, and Borowsky, Alexander D.
Subjects: ESTROGEN receptors, BREAST cancer treatment, BREAST cancer patients, CANCER invasiveness, DISEASE progression, ANTINEOPLASTIC agents, PROTEIN analysis, PROTEIN metabolism, BREAST tumors, CLINICAL trials, COMBINED modality therapy, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, RESEARCH, RESEARCH funding, SURVIVAL analysis (Biometry), TAMOXIFEN, TIME, EVALUATION research, ACQUISITION of data, RETROSPECTIVE studies, TUMOR grading
Abstract: Background: Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors influencing this risk are unknown. We aimed to determine whether high intratumor heterogeneity of ER predicts an increased long-term risk (25 years) of fatal breast cancer.Methods: The STO-3 trial enrolled 1780 postmenopausal lymph node-negative breast cancer patients randomly assigned to receive adjuvant tamoxifen vs not. The fraction of cancer cells for each ER intensity level was scored by breast cancer pathologists, and intratumor heterogeneity of ER was calculated using Rao's quadratic entropy and categorized into high and low heterogeneity using a predefined cutoff at the second tertile (67%). Long-term breast cancer-specific survival analyses by intra-tumor heterogeneity of ER were performed using Kaplan-Meier and multivariable Cox proportional hazard modeling adjusting for patient and tumor characteristics.Results: A statistically significant difference in long-term survival by high vs low intratumor heterogeneity of ER was seen for all ER-positive patients (P < .001) and for patients with luminal A subtype tumors (P = .01). In multivariable analyses, patients with high intratumor heterogeneity of ER had a twofold increased long-term risk as compared with patients with low intratumor heterogeneity (ER-positive: hazard ratio [HR] = 1.98, 95% confidence interval [CI] = 1.31 to 3.00; luminal A subtype tumors: HR = 2.43, 95% CI = 1.18 to 4.99).Conclusions: Patients with high intratumor heterogeneity of ER had an increased long-term risk of fatal breast cancer. Interestingly, a similar long-term risk increase was seen in patients with luminal A subtype tumors. Our findings suggest that intratumor heterogeneity of ER is an independent long-term prognosticator with potential to change clinical management, especially for patients with luminal A tumors. [ABSTRACT FROM AUTHOR]
Published: 2018
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115. Abstract P4-11-12: MammaPrint accurately predicts long-term survival (25 years) and adjuvant tamoxifen therapy benefit in lymph node negative patients

Author: Lindstrom, Linda S, primary, Benz, Christopher C, additional, Yau, Christina, additional, van't Veer, Laura J, additional, Thompson, Carlie K, additional, and Esserman, Laura J, additional
Published: 2015
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116. MicroRNA Related Polymorphisms and Breast Cancer Risk

Author: Khan, Sofia, Greco, Dario, Michailidou, Kyriaki, Milne, Roger L., Muranen, Taru A., Heikkinen, Tuomas, Aaltonen, Kirsimari, Dennis, Joe, Bolla, Manjeet K., Liu, Jianjun, Hall, Per, Irwanto, Astrid, Humphreys, Keith, Li, Jingmei, Czene, Kamila, Chang-Claude, Jenny, Hein, Rebecca, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Fletcher, Olivia, Peto, Julian, Silva, Isabel dos Santos, Johnson, Nichola, Gibson, Lorna, Aitken, Zoe, Hopper, John L., Tsimiklis, Helen, Bui, Minh, Makalic, Enes, Schmidt, Daniel F., Southey, Melissa C., Apicella, Carmel, Stone, Jennifer, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Adank, Muriel A., van der Luijt, Rob B., Meindl, Alfons, Schmutzler, Rita K., Muller-Myhsok, Bertram, Lichtner, Peter, Turnbull, Clare, Rahman, Nazneen, Chanock, Stephen J., Hunter, David J., Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Hogervorst, Frans B., Fasching, Peter A., Schrauder, Michael G., Ekici, Arif B., Beckmann, Matthias W., Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Zamora, Pilar M., Perez, Jose I. A., Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Pharoah, Paul D. P., Dunning, Alison M., Shah, Mitul, Luben, Robert, Brown, Judith, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Olson, Janet E., Lambrechts, Diether, Moisse, Matthieu, Paridaens, Robert, Christiaens, Marie-Rose, Guenel, Pascal, Truong, Therese, Laurent-Puig, Pierre, Mulot, Claire, Marme, Frederick, Burwinkel, Barbara, Schneeweiss, Andreas, Sohn, Christof, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Andrulis, Irene L., Knight, Julia A., Tchatchou, Sandrine, Mulligan, Anna Marie, Dork, Thilo, Bogdanova, Natalia V., Antonenkova, Natalia N., Anton-Culver, Hoda, Darabi, Hatef, Eriksson, Mikael, Garcia-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline, van Asperen, Christi J., Kristensen, Vessela N., Slager, Susan, Toland, Amanda E., Ambrosone, Christine B., Yannoukakos, Drakoulis, Lindblom, Annika, Margolin, Sara, Radice, Paolo, Peterlongo, Paolo, Barile, Monica, Mariani, Paolo, Hooning, Maartje J., Martens, John W. M., Collee, J. Margriet, Jager, Agnes, Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Giles, Graham G., McLean, Catriona, Brauch, Hiltrud, Bruning, Thomas, Ko, Yon-Dschun, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Jones, Michael, Simard, Jacques, Goldberg, Mark S., Labreche, France, Dumont, Martine, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Mannermaa, Arto, Hamann, Ute, Chenevix-Trench, Georgia, Blomqvist, Carl, Aittomaki, Kristiina, Easton, Douglas F., Nevanlinna, Heli, Khan, Sofia, Greco, Dario, Michailidou, Kyriaki, Milne, Roger L., Muranen, Taru A., Heikkinen, Tuomas, Aaltonen, Kirsimari, Dennis, Joe, Bolla, Manjeet K., Liu, Jianjun, Hall, Per, Irwanto, Astrid, Humphreys, Keith, Li, Jingmei, Czene, Kamila, Chang-Claude, Jenny, Hein, Rebecca, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Fletcher, Olivia, Peto, Julian, Silva, Isabel dos Santos, Johnson, Nichola, Gibson, Lorna, Aitken, Zoe, Hopper, John L., Tsimiklis, Helen, Bui, Minh, Makalic, Enes, Schmidt, Daniel F., Southey, Melissa C., Apicella, Carmel, Stone, Jennifer, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Adank, Muriel A., van der Luijt, Rob B., Meindl, Alfons, Schmutzler, Rita K., Muller-Myhsok, Bertram, Lichtner, Peter, Turnbull, Clare, Rahman, Nazneen, Chanock, Stephen J., Hunter, David J., Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Hogervorst, Frans B., Fasching, Peter A., Schrauder, Michael G., Ekici, Arif B., Beckmann, Matthias W., Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Zamora, Pilar M., Perez, Jose I. A., Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Pharoah, Paul D. P., Dunning, Alison M., Shah, Mitul, Luben, Robert, Brown, Judith, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Olson, Janet E., Lambrechts, Diether, Moisse, Matthieu, Paridaens, Robert, Christiaens, Marie-Rose, Guenel, Pascal, Truong, Therese, Laurent-Puig, Pierre, Mulot, Claire, Marme, Frederick, Burwinkel, Barbara, Schneeweiss, Andreas, Sohn, Christof, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Andrulis, Irene L., Knight, Julia A., Tchatchou, Sandrine, Mulligan, Anna Marie, Dork, Thilo, Bogdanova, Natalia V., Antonenkova, Natalia N., Anton-Culver, Hoda, Darabi, Hatef, Eriksson, Mikael, Garcia-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline, van Asperen, Christi J., Kristensen, Vessela N., Slager, Susan, Toland, Amanda E., Ambrosone, Christine B., Yannoukakos, Drakoulis, Lindblom, Annika, Margolin, Sara, Radice, Paolo, Peterlongo, Paolo, Barile, Monica, Mariani, Paolo, Hooning, Maartje J., Martens, John W. M., Collee, J. Margriet, Jager, Agnes, Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Giles, Graham G., McLean, Catriona, Brauch, Hiltrud, Bruning, Thomas, Ko, Yon-Dschun, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Jones, Michael, Simard, Jacques, Goldberg, Mark S., Labreche, France, Dumont, Martine, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Mannermaa, Arto, Hamann, Ute, Chenevix-Trench, Georgia, Blomqvist, Carl, Aittomaki, Kristiina, Easton, Douglas F., and Nevanlinna, Heli
Abstract: Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, including breast cancer, and may alter individual susceptibility to cancer. We investigated associations between miRNA related SNPs and breast cancer risk. First we evaluated 2,196 SNPs in a case-control study combining nine genome wide association studies (GWAS). Second, we further investigated 42 SNPs with suggestive evidence for association using 41,785 cases and 41,880 controls from 41 studies included in the Breast Cancer Association Consortium (BCAC). Combining the GWAS and BCAC data within a meta-analysis, we estimated main effects on breast cancer risk as well as risks for estrogen receptor (ER) and age defined subgroups. Five miRNA binding site SNPs associated significantly with breast cancer risk: rs1045494 (odds ratio (OR) 0.92; 95% confidence interval (CI): 0.88-0.96), rs1052532 (OR 0.97; 95% CI: 0.95-0.99), rs10719 (OR 0.97; 95% CI: 0.94-0.99), rs4687554 (OR 0.97; 95% CI: 0.95-0.99, and rs3134615 (OR 1.03; 95% CI: 1.01-1.05) located in the 3' UTR of CASP8, HDDC3, DROSHA, MUSTN1, and MYCL1, respectively. DROSHA belongs to miRNA machinery genes and has a central role in initial miRNA processing. The remaining genes are involved in different molecular functions, including apoptosis and gene expression regulation. Further studies are warranted to elucidate whether the miRNA binding site SNPs are the causative variants for the observed risk effects.
Published: 2014

117. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.

Author: Broz, Miranda L, Broz, Miranda L, Binnewies, Mikhail, Boldajipour, Bijan, Nelson, Amanda E, Pollack, Joshua L, Erle, David J, Barczak, Andrea, Rosenblum, Michael D, Daud, Adil, Barber, Diane L, Amigorena, Sebastian, Van't Veer, Laura J, Sperling, Anne I, Wolf, Denise M, Krummel, Matthew F, Broz, Miranda L, Broz, Miranda L, Binnewies, Mikhail, Boldajipour, Bijan, Nelson, Amanda E, Pollack, Joshua L, Erle, David J, Barczak, Andrea, Rosenblum, Michael D, Daud, Adil, Barber, Diane L, Amigorena, Sebastian, Van't Veer, Laura J, Sperling, Anne I, Wolf, Denise M, and Krummel, Matthew F
Abstract: It is well understood that antigen-presenting cells (APCs) within tumors typically do not maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse tumor models and human tumor biopsies, we have delineated the intratumoral dendritic cell (DC) populations as distinct from macrophage populations. Within these, CD103(+) DCs are extremely sparse and yet remarkably capable CTL stimulators. These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines. Regressing tumors have higher proportions of these cells, T-cell-dependent immune clearance relies on them, and abundance of their transcripts in human tumors correlates with clinical outcome. This cell type presents opportunities for prognostic and therapeutic approaches across multiple cancer types.
Published: 2014

118. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

Author: Broz, Miranda L., primary, Binnewies, Mikhail, additional, Boldajipour, Bijan, additional, Nelson, Amanda E., additional, Pollack, Joshua L., additional, Erle, David J., additional, Barczak, Andrea, additional, Rosenblum, Michael D., additional, Daud, Adil, additional, Barber, Diane L., additional, Amigorena, Sebastian, additional, van’t Veer, Laura J., additional, Sperling, Anne I., additional, Wolf, Denise M., additional, and Krummel, Matthew F., additional
Published: 2014
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119. Road map to metastasis

Author: Van't Veer, Laura J and Weigelt, Britta
Abstract: Author(s): Laura J Van't Veer [1]; Britta Weigelt [1] The occurrence of metastases in distant organs is the major cause of death for cancer patients. At the time of diagnosis [...]
Published: 2003
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120. The microarray way to tailored cancer treatment

Author: Van't Veer, Laura J. and De Jong, Daphne
Published: 2002
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121. Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Author: Hoadley, Katherine A., primary, Yau, Christina, additional, Wolf, Denise M., additional, Cherniack, Andrew D., additional, Tamborero, David, additional, Ng, Sam, additional, Leiserson, Max D.M., additional, Niu, Beifang, additional, McLellan, Michael D., additional, Uzunangelov, Vladislav, additional, Zhang, Jiashan, additional, Kandoth, Cyriac, additional, Akbani, Rehan, additional, Shen, Hui, additional, Omberg, Larsson, additional, Chu, Andy, additional, Margolin, Adam A., additional, van’t Veer, Laura J., additional, Lopez-Bigas, Nuria, additional, Laird, Peter W., additional, Raphael, Benjamin J., additional, Ding, Li, additional, Robertson, A. Gordon, additional, Byers, Lauren A., additional, Mills, Gordon B., additional, Weinstein, John N., additional, Van Waes, Carter, additional, Chen, Zhong, additional, Collisson, Eric A., additional, Benz, Christopher C., additional, Perou, Charles M., additional, and Stuart, Joshua M., additional
Published: 2014
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122. Imaging Features of HER2 Overexpression in Breast Cancer: A Systematic Review and Meta-analysis

Author: Elias, Sjoerd G., primary, Adams, Arthur, additional, Wisner, Dorota J., additional, Esserman, Laura J., additional, van't Veer, Laura J., additional, Mali, Willem P.Th.M., additional, Gilhuijs, Kenneth G.A., additional, and Hylton, Nola M., additional
Published: 2014
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123. Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

Author: Purrington, Kristen S., primary, Slettedahl, Seth, additional, Bolla, Manjeet K., additional, Michailidou, Kyriaki, additional, Czene, Kamila, additional, Nevanlinna, Heli, additional, Bojesen, Stig E., additional, Andrulis, Irene L., additional, Cox, Angela, additional, Hall, Per, additional, Carpenter, Jane, additional, Yannoukakos, Drakoulis, additional, Haiman, Christopher A., additional, Fasching, Peter A., additional, Mannermaa, Arto, additional, Winqvist, Robert, additional, Brenner, Hermann, additional, Lindblom, Annika, additional, Chenevix-Trench, Georgia, additional, Benitez, Javier, additional, Swerdlow, Anthony, additional, Kristensen, Vessela, additional, Guénel, Pascal, additional, Meindl, Alfons, additional, Darabi, Hatef, additional, Eriksson, Mikael, additional, Fagerholm, Rainer, additional, Aittomäki, Kristiina, additional, Blomqvist, Carl, additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Flyger, Henrik, additional, Wang, Xianshu, additional, Olswold, Curtis, additional, Olson, Janet E., additional, Mulligan, Anna Marie, additional, Knight, Julia A., additional, Tchatchou, Sandrine, additional, Reed, Malcolm W.R., additional, Cross, Simon S., additional, Liu, Jianjun, additional, Li, Jingmei, additional, Humphreys, Keith, additional, Clarke, Christine, additional, Scott, Rodney, additional, Fostira, Florentia, additional, Fountzilas, George, additional, Konstantopoulou, Irene, additional, Henderson, Brian E., additional, Schumacher, Fredrick, additional, Le Marchand, Loic, additional, Ekici, Arif B., additional, Hartmann, Arndt, additional, Beckmann, Matthias W., additional, Hartikainen, Jaana M., additional, Kosma, Veli-Matti, additional, Kataja, Vesa, additional, Jukkola-Vuorinen, Arja, additional, Pylkäs, Katri, additional, Kauppila, Saila, additional, Dieffenbach, Aida Karina, additional, Stegmaier, Christa, additional, Arndt, Volker, additional, Margolin, Sara, additional, Balleine, Rosemary, additional, Arias Perez, Jose Ignacio, additional, Pilar Zamora, M., additional, Menéndez, Primitiva, additional, Ashworth, Alan, additional, Jones, Michael, additional, Orr, Nick, additional, Arveux, Patrick, additional, Kerbrat, Pierre, additional, Truong, Thérèse, additional, Bugert, Peter, additional, Toland, Amanda E., additional, Ambrosone, Christine B., additional, Labrèche, France, additional, Goldberg, Mark S., additional, Dumont, Martine, additional, Ziogas, Argyrios, additional, Lee, Eunjung, additional, Dite, Gillian S., additional, Apicella, Carmel, additional, Southey, Melissa C., additional, Long, Jirong, additional, Shrubsole, Martha, additional, Deming-Halverson, Sandra, additional, Ficarazzi, Filomena, additional, Barile, Monica, additional, Peterlongo, Paolo, additional, Durda, Katarzyna, additional, Jaworska-Bieniek, Katarzyna, additional, Tollenaar, Robert A.E.M., additional, Seynaeve, Caroline, additional, Brüning, Thomas, additional, Ko, Yon-Dschun, additional, Van Deurzen, Carolien H.M., additional, Martens, John W.M., additional, Kriege, Mieke, additional, Figueroa, Jonine D., additional, Chanock, Stephen J., additional, Lissowska, Jolanta, additional, Tomlinson, Ian, additional, Kerin, Michael J., additional, Miller, Nicola, additional, Schneeweiss, Andreas, additional, Tapper, William J., additional, Gerty, Susan M., additional, Durcan, Lorraine, additional, Mclean, Catriona, additional, Milne, Roger L., additional, Baglietto, Laura, additional, dos Santos Silva, Isabel, additional, Fletcher, Olivia, additional, Johnson, Nichola, additional, Van'T Veer, Laura J., additional, Cornelissen, Sten, additional, Försti, Asta, additional, Torres, Diana, additional, Rüdiger, Thomas, additional, Rudolph, Anja, additional, Flesch-Janys, Dieter, additional, Nickels, Stefan, additional, Weltens, Caroline, additional, Floris, Giuseppe, additional, Moisse, Matthieu, additional, Dennis, Joe, additional, Wang, Qin, additional, Dunning, Alison M., additional, Shah, Mitul, additional, Brown, Judith, additional, Simard, Jacques, additional, Anton-Culver, Hoda, additional, Neuhausen, Susan L., additional, Hopper, John L., additional, Bogdanova, Natalia, additional, Dörk, Thilo, additional, Zheng, Wei, additional, Radice, Paolo, additional, Jakubowska, Anna, additional, Lubinski, Jan, additional, Devillee, Peter, additional, Brauch, Hiltrud, additional, Hooning, Maartje, additional, García-Closas, Montserrat, additional, Sawyer, Elinor, additional, Burwinkel, Barbara, additional, Marmee, Frederick, additional, Eccles, Diana M., additional, Giles, Graham G., additional, Peto, Julian, additional, Schmidt, Marjanka, additional, Broeks, Annegien, additional, Hamann, Ute, additional, Chang-Claude, Jenny, additional, Lambrechts, Diether, additional, Pharoah, Paul D.P., additional, Easton, Douglas, additional, Pankratz, V. Shane, additional, Slager, Susan, additional, Vachon, Celine M., additional, and Couch, Fergus J., additional
Published: 2014
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124. Large genomic deletions and duplications in the BRCA1 gene identified by a novel quantitative method

Author: Hogervorst, Frans B. L., Nederlof, Petra M., Gille, Johan J. P., McElgunn, Cathal J., Grippeling, Maartje, Pruntel, Roelof, Regnerus, Rein, van Welsem, Tibor, van Spaendonk, Resie, Menko, Fred H., Kluijt, Irma, Dommering, Charlotte, Verhoef, Senno, Schouten, Jan P., van't Veer, Laura J., Pals, Gerard, Human genetics, CCA - Cancer biology and immunology, and Human Genetics
Subjects: endocrine system diseases, skin and connective tissue diseases
Abstract: We applied a novel method to detect single or multiple exon deletions and amplifications in the BRCA1 gene. The test, called multiplex ligation-dependent probe amplification (MLPA), uses probes designed to hybridize adjacently to the target sequence. After ligation, the joined probes are amplified and quantified. Our two diagnostic laboratories have tested in the recent years 805 families by conventional PCR-based techniques, and found 116 BRCA1 and 28 BRCA2 mutation-positive families. Using MLPA, we have tested the remaining 661 noninformative breast cancer families and identified five distinct BRCA1 germ-line mutations in five families: a deletion of exon 8, a deletion of exons 20-22, a duplication of exon 13 and exons 21-23, respectively, and a triplication, encompassing exons 17-19. Genomic deletions of BRCA1 constitute a substantial fraction of mutations in Dutch breast cancer families. If MLPA had been included in our initial BRCA1 testing, 33 families with a deletion or duplication would have been identified, representing 27% of the total 121 BRCA1 mutation-positive families. The MLPA test for BRCA1 ensures a sensitive and comprehensive high-throughput screening test for genomic rearrangement and can easily be implemented in the molecular analysis of BRCA1.
Published: 2003

125. Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1

Author: Meyer, Kerstin B., O'Reilly, Martin, Michailidou, Kyriaki, Carlebur, Saskia, Edwards, Stacey L., French, Juliet D., Prathalingham, Radhika, Dennis, Joe, Bolla, Manjeet K., Wang, Qin, de Santiago, Ines, Hopper, John L., Tsimiklis, Helen, Apicella, Carmel, Southey, Melissa C., Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Hogervorst, Frans B., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Lux, Michael P., Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Silva, Isabel dos Santos, Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Marme, Federick, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Guenel, Pascal, Truong, Therese, Laurent-Puig, Pierre, Menegaux, Florence, Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Milne, Roger L., Pilar Zamora, M., Arias, Jose I., Benitez, Javier, Neuhausen, Susan, Anton-Culver, Hoda, Ziogas, Argyrios, Dur, Christina C., Brenner, Hermann, Mueller, Heiko, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Schmutzler, Rita K., Engel, Christoph, Ditsch, Nina, Brauch, Hiltrud, Bruening, Thomas, Ko, Yon-Dschun, Nevanlinna, Heli, Muranen, Taru A., Aittomaeki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Yatabe, Yasushi, Doerk, Thilo, Helbig, Sonja, Bogdanova, Natalia V., Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Chenevix-Trench, Georgia, Wu, Anna H., Tseng, Chiu-chen, Van Den Berg, David, Stram, Daniel O., Lambrechts, Diether, Thienpont, Bernard, Christiaens, Marie-Rose, Smeets, Ann, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Bernard, Loris, Couch, Fergus J., Olson, Janet E., Wang, Xianshu, Purrington, Kristen, Giles, Graham G., Severi, Gianluca, Baglietto, Laura, McLean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Simard, Jacques, Goldberg, Mark S., Labreche, France, Dumont, Martine, Teo, Soo-Hwang, Yip, Cheng-Har, Phuah, Sze-Yee, Kristensen, Vessela, Alnaes, Grethe Grenaker, Borresen-Dale, Anne-Lise, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha, Long, Jirong, Winqvist, Robert, Pylkaes, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline M., Garcia-Closas, Montserrat, Figueroa, Jonine, Chanock, Stephen J., Lissowska, Jolanta, Czene, Kamila, Darabi, Hartef, Eriksson, Kimael, Hooning, Maartje J., Martens, John W. M., van den Ouweland, Ans M. W., van Deurzen, Carolien H. M., Hall, Per, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Cox, Angela, Reed, Malcolm W. R., Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D. P., Ghoussaini, Maya, Harrington, Patricia, Tyrer, Jonathan, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K., Noh, Dong-Young, Hartman, Mikael, Hui, Miao, Lim, Wei-Yen, Buhari, Shaik A., Hamann, Ute, Foersti, Asta, Ruediger, Thomas, Ulmer, Hans-Ulrich, Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Vachon, Celine, Slager, Susan, Fostira, Florentia, Pilarski, Robert, Shen, Chen-Yang, Hsiung, Chia-Ni, Wu, Pei-Ei, Hou, Ming-Feng, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Schoemaker, Minouk J., Ponder, Bruce A. J., Dunning, Alison M., Easton, Douglas F., Meyer, Kerstin B., O'Reilly, Martin, Michailidou, Kyriaki, Carlebur, Saskia, Edwards, Stacey L., French, Juliet D., Prathalingham, Radhika, Dennis, Joe, Bolla, Manjeet K., Wang, Qin, de Santiago, Ines, Hopper, John L., Tsimiklis, Helen, Apicella, Carmel, Southey, Melissa C., Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Hogervorst, Frans B., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Lux, Michael P., Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Silva, Isabel dos Santos, Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Marme, Federick, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Guenel, Pascal, Truong, Therese, Laurent-Puig, Pierre, Menegaux, Florence, Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Milne, Roger L., Pilar Zamora, M., Arias, Jose I., Benitez, Javier, Neuhausen, Susan, Anton-Culver, Hoda, Ziogas, Argyrios, Dur, Christina C., Brenner, Hermann, Mueller, Heiko, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Schmutzler, Rita K., Engel, Christoph, Ditsch, Nina, Brauch, Hiltrud, Bruening, Thomas, Ko, Yon-Dschun, Nevanlinna, Heli, Muranen, Taru A., Aittomaeki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Yatabe, Yasushi, Doerk, Thilo, Helbig, Sonja, Bogdanova, Natalia V., Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Chenevix-Trench, Georgia, Wu, Anna H., Tseng, Chiu-chen, Van Den Berg, David, Stram, Daniel O., Lambrechts, Diether, Thienpont, Bernard, Christiaens, Marie-Rose, Smeets, Ann, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Bernard, Loris, Couch, Fergus J., Olson, Janet E., Wang, Xianshu, Purrington, Kristen, Giles, Graham G., Severi, Gianluca, Baglietto, Laura, McLean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Simard, Jacques, Goldberg, Mark S., Labreche, France, Dumont, Martine, Teo, Soo-Hwang, Yip, Cheng-Har, Phuah, Sze-Yee, Kristensen, Vessela, Alnaes, Grethe Grenaker, Borresen-Dale, Anne-Lise, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha, Long, Jirong, Winqvist, Robert, Pylkaes, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline M., Garcia-Closas, Montserrat, Figueroa, Jonine, Chanock, Stephen J., Lissowska, Jolanta, Czene, Kamila, Darabi, Hartef, Eriksson, Kimael, Hooning, Maartje J., Martens, John W. M., van den Ouweland, Ans M. W., van Deurzen, Carolien H. M., Hall, Per, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Cox, Angela, Reed, Malcolm W. R., Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D. P., Ghoussaini, Maya, Harrington, Patricia, Tyrer, Jonathan, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K., Noh, Dong-Young, Hartman, Mikael, Hui, Miao, Lim, Wei-Yen, Buhari, Shaik A., Hamann, Ute, Foersti, Asta, Ruediger, Thomas, Ulmer, Hans-Ulrich, Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Vachon, Celine, Slager, Susan, Fostira, Florentia, Pilarski, Robert, Shen, Chen-Yang, Hsiung, Chia-Ni, Wu, Pei-Ei, Hou, Ming-Feng, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Schoemaker, Minouk J., Ponder, Bruce A. J., Dunning, Alison M., and Easton, Douglas F.
Abstract: The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of European ancestry, 9 Asian ancestry studies (n = 13,983), and 2 African ancestry studies (n = 2,028) from the Breast Cancer Association Consortium. We identified three statistically independent risk signals within the locus. Within risk signals 1 and 3, genetic analysis identified five and two variants, respectively, highly correlated with the most strongly associated SNPs. By using a combination of genetic fine mapping, data on DNase hypersensitivity, and electrophoretic mobility shift assays to study protein-DNA binding, we identified rs35054928, rs2981578, and rs45631563 as putative functional SNPs. Chromatin immunoprecipitation showed that FOXA1 preferentially bound to the risk-associated allele (C) of rs2981578 and was able to recruit ER alpha to this site in an allele-specific manner, whereas E2F1 preferentially bound the risk variant of rs35054928. The risk alleles were preferentially found in open chromatin and bound by Ser5 phosphorylated RNA polymerase II, suggesting that the risk alleles are associated with changes in transcription. Chromatin conformation capture demonstrated that the risk region was able to interact with the promoter of FGFR2, the likely target gene of this risk region. A role for FOXA1 in mediating breast cancer susceptibility at this locus is consistent with the finding that the FGFR2 risk locus primarily predisposes to estrogen-receptor-positive disease.
Published: 2013

126. New Horizons in Advocacy Engaged Physical Sciences and Oncology Research

Author: Samson, Susan, Northey, Jason J., Plaks, Vicki, Baas, Carole, Dean, Ivory, LaBarge, Mark A., Goga, Andrei, Van’t Veer, Laura J., and Weaver, Valerie M.
Abstract: To address cancer as a multifaceted adaptive system, the increasing momentum for cross-disciplinary connectivity between cancer biologists, physical scientists, mathematicians, chemists, biomedical engineers, computer scientists, clinicians, and advocates is fueling the emergence of new scientific frontiers, principles, and opportunities within physical sciences and oncology. In parallel to highlighting the advances, challenges, and acceptance of advocates as credible contributors, we offer recommendations for addressing real world hurdles in advancing equitable partnerships among advocacy stakeholders.
Published: 2018
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127. Performance characteristics of the MammaPrint® breast cancer diagnostic gene signature

Author: Delahaye, Leonie JM, primary, Wehkamp, Diederik, additional, Floore, Arno N, additional, Bernards, Rene, additional, van‘t Veer, Laura J, additional, and Glas, Annuska M, additional
Published: 2013
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128. The role of genetic breast cancer susceptibility variants as prognostic factors

Author: Fasching, Peter A, Pharoah, Paul D P, Cox, Angela, Nevanlinna, Heli, Bojesen, Stig E, Karn, Thomas, Broeks, Annegien, van Leeuwen, Flora E, van't Veer, Laura J, Udo, Renate, Dunning, Alison M, Greco, Dario, Aittomäki, Kristiina, Blomqvist, Carl, Shah, Mitul, Nordestgaard, Børge G, Flyger, Henrik, Hopper, John L, Southey, Melissa C, Apicella, Carmel, Garcia-Closas, Montserrat, Sherman, Mark, Lissowska, Jolanta, Seynaeve, Caroline, Huijts, Petra E A, Tollenaar, Rob A E M, Ziogas, Argyrios, Ekici, Arif B, Rauh, Claudia, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Andrulis, Irene L, Ozcelik, Hilmi, Mulligan, Anna-Marie, Glendon, Gord, Hall, Per, Czene, Kamila, Liu, Jianjun, Chang-Claude, Jenny, Wang-Gohrke, Shan, Eilber, Ursula, Nickels, Stefan, Dörk, Thilo, Schiekel, Maria, Bremer, Michael, Park-Simon, Tjoung-Won, Giles, Graham G, Severi, Gianluca, Fasching, Peter A, Pharoah, Paul D P, Cox, Angela, Nevanlinna, Heli, Bojesen, Stig E, Karn, Thomas, Broeks, Annegien, van Leeuwen, Flora E, van't Veer, Laura J, Udo, Renate, Dunning, Alison M, Greco, Dario, Aittomäki, Kristiina, Blomqvist, Carl, Shah, Mitul, Nordestgaard, Børge G, Flyger, Henrik, Hopper, John L, Southey, Melissa C, Apicella, Carmel, Garcia-Closas, Montserrat, Sherman, Mark, Lissowska, Jolanta, Seynaeve, Caroline, Huijts, Petra E A, Tollenaar, Rob A E M, Ziogas, Argyrios, Ekici, Arif B, Rauh, Claudia, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Andrulis, Irene L, Ozcelik, Hilmi, Mulligan, Anna-Marie, Glendon, Gord, Hall, Per, Czene, Kamila, Liu, Jianjun, Chang-Claude, Jenny, Wang-Gohrke, Shan, Eilber, Ursula, Nickels, Stefan, Dörk, Thilo, Schiekel, Maria, Bremer, Michael, Park-Simon, Tjoung-Won, Giles, Graham G, and Severi, Gianluca
Abstract: Recent genome-wide association studies identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. We investigated these and 62 other SNPs for their prognostic relevance. Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients. Cox proportional hazard models were used to test the association of these SNPs with overall survival (OS) and BC-specific survival (BCS). For the confirmed loci, we performed an accessory analysis of publicly available gene expression data and the prognosis in a different patient group. One of the 11 SNPs, rs3803662 (TOX3) and none of the 62 candidate/GWAS SNPs were associated with OS and/or BCS at P
Published: 2012

129. Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer

Author: Milne, Roger L., Goode, Ellen L., Garca-Closas, Montserrat, Couch, Fergus J., Severi, Gianluca, Hein, Rebecca, Fredericksen, Zachary, Malats, Nuria, Pilar Zamora, M., Arias Perez, Jose Ignacio, Benitez, Javier, Doerk, Thilo, Schuermann, Peter, Karstens, Johann H., Hillemanns, Peter, Cox, Angela, Brock, Ian W., Elliot, Graeme, Cross, Simon S., Seal, Sheila, Turnbull, Clare, Renwick, Anthony, Rahman, Nazneen, Shen, Chen-Yang, Yu, Jyh-Cherng, Huang, Chiun-Sheng, Hou, Ming-Feng, Nordestgaard, Borge G., Bojesen, Stig E., Lanng, Charlotte, Alnaes, Grethe Grenaker, Kristensen, Vessela, Borrensen-Dale, Anne-Lise, Hopper, John L., Dite, Gillian S., Apicella, Carmel, Southey, Melissa C., Lambrechts, Diether, Yesilyurt, Betul T., Floris, Giuseppe, Leunen, Karin, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, McKay, James, Chang-Claude, Jenny, Wang-Gohrke, Shan, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Barile, Monica, Giles, Graham G., Baglietto, Laura, John, Esther M., Miron, Alexander, Chanock, Stephen J., Lissowska, Jolanta, Sherman, Mark E., Figueroa, Jonine D., Bogdanova, Natalia V., Antonenkova, Natalia N., Zalutsky, Iosif V., Rogov, Yuri I., Fasching, Peter A., Bayer, Christian M., Ekici, Arif B., Beckmann, Matthias W., Brenner, Hermann, Mueller, Heiko, Arndt, Volker, Stegmaier, Christa, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Mulligan, Anna Marie, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Meindl, Alfons, Heil, Joerg, Bartram, Claus R., Schmutzler, Rita K., Thomas, Gilles D., Hoover, Robert N., Fletcher, Olivia, Gibson, Lorna J., Silva, Isabel dos Santos, Peto, Julian, Nickels, Stefan, Flesch-Janys, Dieter, Anton-Culver, Hoda, Ziogas, Argyrios, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Miller, Nicola, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Tollenaar, Rob A. E. M., Pharoah, Paul D. P., Dunning, Alison M., Pooley, Karen A., Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Kraft, Peter, Lindstrom, Sara, Chen, Xiaoqing, Beesley, Jonathan, Hamann, Ute, Harth, Volker, Justenhoven, Christina, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Hooning, Maartje, Hollestelle, Antoinette, Oldenburg, Rogier A., Tilanus-Linthorst, Madeleine, Khusnutdinova, Elza, Bermisheva, Marina, Prokofieva, Darya, Farahtdinova, Albina, Olson, Janet E., Wang, Xianshu, Humphreys, Manjeet K., Wang, Qin, Chenevix-Trench, Georgia, Easton, Douglas F., Milne, Roger L., Goode, Ellen L., Garca-Closas, Montserrat, Couch, Fergus J., Severi, Gianluca, Hein, Rebecca, Fredericksen, Zachary, Malats, Nuria, Pilar Zamora, M., Arias Perez, Jose Ignacio, Benitez, Javier, Doerk, Thilo, Schuermann, Peter, Karstens, Johann H., Hillemanns, Peter, Cox, Angela, Brock, Ian W., Elliot, Graeme, Cross, Simon S., Seal, Sheila, Turnbull, Clare, Renwick, Anthony, Rahman, Nazneen, Shen, Chen-Yang, Yu, Jyh-Cherng, Huang, Chiun-Sheng, Hou, Ming-Feng, Nordestgaard, Borge G., Bojesen, Stig E., Lanng, Charlotte, Alnaes, Grethe Grenaker, Kristensen, Vessela, Borrensen-Dale, Anne-Lise, Hopper, John L., Dite, Gillian S., Apicella, Carmel, Southey, Melissa C., Lambrechts, Diether, Yesilyurt, Betul T., Floris, Giuseppe, Leunen, Karin, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, McKay, James, Chang-Claude, Jenny, Wang-Gohrke, Shan, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Barile, Monica, Giles, Graham G., Baglietto, Laura, John, Esther M., Miron, Alexander, Chanock, Stephen J., Lissowska, Jolanta, Sherman, Mark E., Figueroa, Jonine D., Bogdanova, Natalia V., Antonenkova, Natalia N., Zalutsky, Iosif V., Rogov, Yuri I., Fasching, Peter A., Bayer, Christian M., Ekici, Arif B., Beckmann, Matthias W., Brenner, Hermann, Mueller, Heiko, Arndt, Volker, Stegmaier, Christa, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Mulligan, Anna Marie, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Meindl, Alfons, Heil, Joerg, Bartram, Claus R., Schmutzler, Rita K., Thomas, Gilles D., Hoover, Robert N., Fletcher, Olivia, Gibson, Lorna J., Silva, Isabel dos Santos, Peto, Julian, Nickels, Stefan, Flesch-Janys, Dieter, Anton-Culver, Hoda, Ziogas, Argyrios, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Miller, Nicola, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Tollenaar, Rob A. E. M., Pharoah, Paul D. P., Dunning, Alison M., Pooley, Karen A., Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Kraft, Peter, Lindstrom, Sara, Chen, Xiaoqing, Beesley, Jonathan, Hamann, Ute, Harth, Volker, Justenhoven, Christina, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Hooning, Maartje, Hollestelle, Antoinette, Oldenburg, Rogier A., Tilanus-Linthorst, Madeleine, Khusnutdinova, Elza, Bermisheva, Marina, Prokofieva, Darya, Farahtdinova, Albina, Olson, Janet E., Wang, Xianshu, Humphreys, Manjeet K., Wang, Qin, Chenevix-Trench, Georgia, and Easton, Douglas F.
Abstract: Background: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium. Methods: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression. Results: For white Europeans, the per-allele OR associated with 5p12-rs10941679 was 1.11 (95% CI = 1.08-1.14, P = 7 x 10(-18)) for invasive breast cancer and 1.10 (95% CI = 1.01-1.21, P = 0.03) for DCIS. For Asian women, the estimated OR for invasive disease was similar (OR 1.07, 95% CI = 0.99-1.15, P = 0.09). Further analyses suggested that the association in white Europeans was largely limited to progesterone receptor (PR)positive disease (per-allele OR = 1.16, 95% CI = 1.12-1.20, P = 1 x 10(-18) vs. OR = 1.03, 95% CI = 0.99-1.07, P = 0.2 for PR-negative disease; P-heterogeneity 2 x 10(-7)); heterogeneity by ER status was not observed (P = 0.2) once PR status was accounted for. The association was also stronger for lower grade tumors [per-allele OR (95% CI) 1.20 (1.14-1.25), 1.13 (1.09-1.16), and 1.04 (0.99-1.08) for grade 1, 2, and 3/4, respectively; Ptrend 5 x 10(-7)]. Conclusion: 5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer. Impact: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants. Cancer Epidemiol Biomarkers Prev; 20(10); 2222-31. (C) 2011 AACR.
Published: 2011

130. Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype:findings from the Breast Cancer Association Consortium

Author: Figueroa, Jonine D, Garcia-Closas, Montserrat, Humphreys, Manjeet, Platte, Radka, Hopper, John L, Southey, Melissa C, Apicella, Carmel, Hammet, Fleur, Schmidt, Marjanka K, Broeks, Annegien, Tollenaar, Rob A E M, Van't Veer, Laura J, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Strick, Reiner, Peto, Julian, dos Santos Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Burwinkel, Barbara, Marme, Federik, Schneeweiss, Andreas, Sohn, Christof, Bojesen, Stig, Flyger, Henrik, Nordestgaard, Børge G, Benítez, Javier, Milne, Roger L, Ignacio Arias, Jose, Zamora, M Pilar, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Rahman, Nazneen, Turnbull, Clare, Seal, Sheila, Renwick, Anthony, Brauch, Hiltrud, Justenhoven, Christina, Brüning, Thomas, Chang-Claude, Jenny, Hein, Rebecca, Wang-Gohrke, Shan, Dörk, Thilo, Schürmann, Peter, Bremer, Michael, Figueroa, Jonine D, Garcia-Closas, Montserrat, Humphreys, Manjeet, Platte, Radka, Hopper, John L, Southey, Melissa C, Apicella, Carmel, Hammet, Fleur, Schmidt, Marjanka K, Broeks, Annegien, Tollenaar, Rob A E M, Van't Veer, Laura J, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Strick, Reiner, Peto, Julian, dos Santos Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Burwinkel, Barbara, Marme, Federik, Schneeweiss, Andreas, Sohn, Christof, Bojesen, Stig, Flyger, Henrik, Nordestgaard, Børge G, Benítez, Javier, Milne, Roger L, Ignacio Arias, Jose, Zamora, M Pilar, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Rahman, Nazneen, Turnbull, Clare, Seal, Sheila, Renwick, Anthony, Brauch, Hiltrud, Justenhoven, Christina, Brüning, Thomas, Chang-Claude, Jenny, Hein, Rebecca, Wang-Gohrke, Shan, Dörk, Thilo, Schürmann, Peter, and Bremer, Michael
Abstract: A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci for estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), grade, node status, tumor size, and ductal or lobular morphology. We genotyped rs11249433 at 1p.11.2, and two highly correlated SNPs rs999737 and rs10483813 (r(2)= 0.98) at 14q24.1 (RAD51L1), for up to 46 036 invasive breast cancer cases and 46 930 controls from 39 studies. Analyses by tumor characteristics focused on subjects reporting to be white women of European ancestry and were based on 25 458 cases, of which 87% had ER data. The SNP at 1p11.2 showed significantly stronger associations with ER-positive tumors [per-allele odds ratio (OR) for ER-positive tumors was 1.13, 95% CI = 1.10-1.16 and, for ER-negative tumors, OR was 1.03, 95% CI = 0.98-1.07, case-only P-heterogeneity = 7.6 × 10(-5)]. The association with ER-positive tumors was stronger for tumors of lower grade (case-only P= 6.7 × 10(-3)) and lobular histology (case-only P= 0.01). SNPs at 14q24.1 were associated with risk for most tumor subtypes evaluated, including triple-negative breast cancers, which has not been described previously. Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer.
Published: 2011

131. Specific genomic aberrations in primary colorectal cancer are associated with liver metastases

Author: Bruin, Sjoerd C. (author), Klijn, C.N. (author), Liefers, Gerrit Jan (author), Braaf, Linde M. (author), Joosse, Simon A. (author), Van Beers, Eric H. (author), Verwaal, Victor J. (author), Morreau, Hans (author), Wessels, L.F.A. (author), Van Velthuysen, Marie Louise F. (author), Tollenaar, Rob A.E.M. (author), Van't Veer, Laura J. (author), Bruin, Sjoerd C. (author), Klijn, C.N. (author), Liefers, Gerrit Jan (author), Braaf, Linde M. (author), Joosse, Simon A. (author), Van Beers, Eric H. (author), Verwaal, Victor J. (author), Morreau, Hans (author), Wessels, L.F.A. (author), Van Velthuysen, Marie Louise F. (author), Tollenaar, Rob A.E.M. (author), and Van't Veer, Laura J. (author)
Abstract: Background: Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases.Methods: Array Comparative Genomic Hybridization (aCGH) was employed to asses DNA copy number changes in primary colorectal tumors of three distinctive patient groups. This included formalin-fixed, paraffin-embedded tissue of patients who developed liver metastases (LM; n = 36), metastases (PM; n = 37) and a group that remained metastases-free (M0; n = 25).A novel statistical method for identifying recurrent copy number changes, KC-SMART, was used to find specific locations of genomic aberrations specific for various groups. We created a classifier for organ specific metastases based on the aCGH data using Prediction Analysis for Microarrays (PAM).Results: Specifically in the tumors of primary CRC patients who subsequently developed liver metastasis, KC-SMART analysis identified genomic aberrations on chromosome 20q. LM-PAM, a shrunken centroids classifier for liver metastases occurrence, was able to distinguish the LM group from the other groups (M0&PM) with 80% accuracy (78% sensitivity and 86% specificity). The classification is predominantly based on chromosome 20q aberrations.Conclusion: Liver specific CRC metastases may be predicted with a high accuracy based on specific genomic aberrations in the primary CRC tumor. The ability to predict the site of metastases is important for improvement of personalized patient management., Pattern Recognition and Bioinformatics
Published: 2010
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132. Family history, genetic testing, and clinical risk prediction : pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls

Author: Fletcher, Olivia, Johnson, Nichola, Dos Santos Silva, Isabel, Kilpivaara, Outi, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Wasielewski, Marijke, Meijers-Heijerboer, Hanne, Broeks, Annegien, Schmidt, Marjanka K., Van't Veer, Laura J., Bremer, Michael, Dörk, Thilo, Chekmariova, Elena V., Sokolenko, Anna P., Imyanitov, Evgeny N., Hamann, Ute, Rashid, Muhammad U., Brauch, Hiltrud, Justenhoven, Christina, Ashworth, Alan, Peto, Julian, Fletcher, Olivia, Johnson, Nichola, Dos Santos Silva, Isabel, Kilpivaara, Outi, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Wasielewski, Marijke, Meijers-Heijerboer, Hanne, Broeks, Annegien, Schmidt, Marjanka K., Van't Veer, Laura J., Bremer, Michael, Dörk, Thilo, Chekmariova, Elena V., Sokolenko, Anna P., Imyanitov, Evgeny N., Hamann, Ute, Rashid, Muhammad U., Brauch, Hiltrud, Justenhoven, Christina, Ashworth, Alan, and Peto, Julian
Abstract: If breast cancers arise independently in each breast the odds ratio (OR) for bilateral breast cancer for carriers of CHEK2 1100delC should be approximately 5.5, the square of the reported OR for a first primary (OR, 2.34). In the subset of bilateral cases with one or more affected relatives, the predicted carrier OR should be approximately 9. We have tested these predictions in a pooled set of 1,828 cases with 2 primaries and 7,030 controls from 8 studies. The second primary OR for CHEK2 1100delC carriers was 6.43 (95% confidence interval, 4.33-9.56; P < 0.0001), significantly greater than the published estimate for a first primary (P < 0.001) but consistent with its square. The predicted increase in carrier OR with increasing numbers of affected relatives was seen using bilateral cases from the UK (P(trend) = 0.0003) and Finland (P(trend) = 0.37), although not using those from the Netherlands and Russia (P = 0.001 for heterogeneity between countries). Based on a standard genetic model, we predict lifetime risks for CHEK2 1100delC carrier and noncarrier daughters of bilateral breast cancer cases of 37% and 18%, respectively. Our results imply that clinical management of the daughter of a woman with bilateral breast cancer should depend on her CHEK2 1100delC carrier status. This and other moderate penetrance breast cancer susceptibility alleles, together with family history data, will thus identify increasing numbers of women at potentially very high risk. Before such predictions are accepted by clinical geneticists, however, further population-based evidence is needed on the effect of CHEK2 1100delC and other moderate penetrance alleles in women with a family history of breast cancer.
Published: 2009
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133. An information-theoretic analysis of genetics, gender and age in cancer patients

Author: University of Helsinki, Women's Health Research Program, University of Helsinki, Medicum, Atwal, Gurinder Singh, Rabadan, Raul, Lozano, Guillermina, Strong, Louise C, Ruijs, Marielle W. G, Schmidt, Marjanka K, van't Veer, Laura J, Nevanlinna, Heli, Tommiska, Johanna, Aittomäki, Kristiina, Bougeard, Gaelle, Frebourg, Thierry, Levine, Arnold J, Bond, Gareth L, University of Helsinki, Women's Health Research Program, University of Helsinki, Medicum, Atwal, Gurinder Singh, Rabadan, Raul, Lozano, Guillermina, Strong, Louise C, Ruijs, Marielle W. G, Schmidt, Marjanka K, van't Veer, Laura J, Nevanlinna, Heli, Tommiska, Johanna, Aittomäki, Kristiina, Bougeard, Gaelle, Frebourg, Thierry, Levine, Arnold J, and Bond, Gareth L
Published: 2008

134. A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences

Author: Mittempergher, Lorenza, primary, Saghatchian, Mahasti, additional, Wolf, Denise M., additional, Michiels, Stefan, additional, Canisius, Sander, additional, Dessen, Philippe, additional, Delaloge, Suzette, additional, Lazar, Vladimir, additional, Benz, Stephen C., additional, Tursz, Thomas, additional, Bernards, René, additional, and van't Veer, Laura J., additional
Published: 2013
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135. A common coding variant in CASP8 is associated with breast cancer risk

Author: Cox, Angela, Dunning, Alison M., Garcia-Closas, Montserrat, Balasubramanian, Sabapathy, Reed, Malcolm W. R., Pooley, Karen A., Scollen, Serena, Baynes, Caroline, Ponder, Bruce A. J., Chanock, Stephen, Lissowska, Jolanta, Brinton, Louise, Peplonska, Beata, Southey, Melissa C., Hopper, John L., McCredie, Margaret R. E., Giles, Graham G., Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Gibson, Lorna, Bojesen, Stig E., Nordestgaard, Børge G., Axelsson, Christen K., Torres, Diana, Hamann, Ute, Justenhoven, Christina, Brauch, Hiltrud, Chang-Claude, Jenny, Kropp, Silke, Risch, Angela, Wang-Gohrke, Shan, Schürmann, Peter, Bogdanova, Natalia, Dörk, Thilo, Fagerholm, Rainer, Aaltonen, Kirsimari, Blomqvist, Carl, Nevanlinna, Heli, Seal, Sheila, Renwick, Anthony, Stratton, Michael R., Rahman, Nazneen, Sangrajrang, Suleeporn, Hughes, David, Odefrey, Fabrice, Brennan, Paul, Spurdle, Amanda B., Chenevix-Trench, Georgia, Beesley, Jonathan, Mannermaa, Arto, Hartikainen, Jaana, Kataja, Vesa, Kosma, Veli-Matti, Couch, Fergus J., Olson, Janet E., Goode, Ellen L., Broeks, Annegien, Schmidt, Marjanka K., Hogervorst, Frans B. L., Van't Veer, Laura J., Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Wedrén, Sara, Hall, Per, Low, Yen-Ling, Liu, Jianjun, Milne, Roger L, Ribas, Gloria, Gonzalez-Neira, Anna, Benitez, Javier, Sigurdson, Alice J., Stredrick, Denise L., Alexander, Bruce H., Struewing, Jeffery P., Pharoah, Paul D. P., Easton, Douglas F., Cox, Angela, Dunning, Alison M., Garcia-Closas, Montserrat, Balasubramanian, Sabapathy, Reed, Malcolm W. R., Pooley, Karen A., Scollen, Serena, Baynes, Caroline, Ponder, Bruce A. J., Chanock, Stephen, Lissowska, Jolanta, Brinton, Louise, Peplonska, Beata, Southey, Melissa C., Hopper, John L., McCredie, Margaret R. E., Giles, Graham G., Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Gibson, Lorna, Bojesen, Stig E., Nordestgaard, Børge G., Axelsson, Christen K., Torres, Diana, Hamann, Ute, Justenhoven, Christina, Brauch, Hiltrud, Chang-Claude, Jenny, Kropp, Silke, Risch, Angela, Wang-Gohrke, Shan, Schürmann, Peter, Bogdanova, Natalia, Dörk, Thilo, Fagerholm, Rainer, Aaltonen, Kirsimari, Blomqvist, Carl, Nevanlinna, Heli, Seal, Sheila, Renwick, Anthony, Stratton, Michael R., Rahman, Nazneen, Sangrajrang, Suleeporn, Hughes, David, Odefrey, Fabrice, Brennan, Paul, Spurdle, Amanda B., Chenevix-Trench, Georgia, Beesley, Jonathan, Mannermaa, Arto, Hartikainen, Jaana, Kataja, Vesa, Kosma, Veli-Matti, Couch, Fergus J., Olson, Janet E., Goode, Ellen L., Broeks, Annegien, Schmidt, Marjanka K., Hogervorst, Frans B. L., Van't Veer, Laura J., Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Wedrén, Sara, Hall, Per, Low, Yen-Ling, Liu, Jianjun, Milne, Roger L, Ribas, Gloria, Gonzalez-Neira, Anna, Benitez, Javier, Sigurdson, Alice J., Stredrick, Denise L., Alexander, Bruce H., Struewing, Jeffery P., Pharoah, Paul D. P., and Easton, Douglas F.
Abstract: The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.
Published: 2007
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136. Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium

Author: Schmidt, Marjanka K, Reincke, Scarlett, Broeks, Annegien, Braaf, Linde M, Hogervorst, Frans B L, Tollenaar, Rob A E M, Johnson, Nichola, Fletcher, Olivia, Peto, Julian, Tommiska, Johanna, Blomqvist, Carl, Nevanlinna, Heli A, Healey, Catherine S, Dunning, Alison M, Pharoah, Paul D P, Easton, Douglas F, Dörk, Thilo, Van't Veer, Laura J, Schmidt, Marjanka K, Reincke, Scarlett, Broeks, Annegien, Braaf, Linde M, Hogervorst, Frans B L, Tollenaar, Rob A E M, Johnson, Nichola, Fletcher, Olivia, Peto, Julian, Tommiska, Johanna, Blomqvist, Carl, Nevanlinna, Heli A, Healey, Catherine S, Dunning, Alison M, Pharoah, Paul D P, Easton, Douglas F, Dörk, Thilo, and Van't Veer, Laura J
Abstract: Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility. Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk. Data from molecular studies suggest a functional interaction between these genes. We therefore investigated the effect of TP53 R72P and MDM2 SNP309 on breast cancer risk and age at onset of breast cancer in a pooled series of 5,191 cases and 3,834 controls from the Breast Cancer Association Consortium (BCAC). Breast cancer risk was not found to be associated with the combined variant alleles [odds ratio (OR), 1.00; 95% confidence interval (95% CI), 0.81–1.23]. Estimated ORs were 1.01 (95% CI, 0.93–1.09) per MDM2 SNP309 allele and 0.98 (95% CI, 0.91–1.04) for TP53 R72P. Although we did find evidence for a 4-year earlier age at onset for carriers of both variant alleles in one of the breast cancer patient series of the BCAC (the German series), we were not able to confirm this effect in the pooled analysis. Even so, carriers of both variant alleles did not have different risk estimates for bilateral or estrogen receptor–positive breast cancer. In conclusion, in this large collaborative study, we did not find an association of MDM2 SNP309 and TP53 R72P, separately or in interaction, with breast cancer. This suggests that any effect of these two variants would be very small and possibly confined to subgroups that were not assessed in our present study.
Published: 2007
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137. Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Mutation Carriers.

Author: van den Broek, Alexandra J., van't Veer, Laura J., Hooning, Maartje J., Cornelissen, Sten, Broeks, Annegien, Rutgers, Emiel J., Smit, Vincent T. H. B. M., Cornelisse, Cees J., van Beek, Mike, Janssen-Heijnen, Maryska L., Seynaeve, Caroline, Westenend, Pieter J., Jobsen, Jan J., Siesling, Sabine, Tollenaar, Rob A. E. M., van Leeuwen, Flora E., and Schmidt, Marjanka K.
Published: 2016
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138. An “elite hacker”

Author: Boudreau, Aaron, primary, van't Veer, Laura J., additional, and Bissell, Mina J., additional
Published: 2012
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139. Abstract 4558: FDG-PET uptake in breast cancer molecular subtypes

Author: Elias, Sjoerd G., primary, Wisner, Dorota J., additional, Chen, Yunn-Yi, additional, Behr, Spencer C., additional, Griffin, Ann, additional, Esserman, Laura J., additional, van't Veer, Laura J., additional, and Hylton, Nola M., additional
Published: 2012
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140. A Prognostic Gene Expression Profile That Predicts Circulating Tumor Cell Presence in Breast Cancer Patients

Author: Molloy, Timothy J., primary, Roepman, Paul, additional, Naume, Bjørn, additional, and van't Veer, Laura J., additional
Published: 2012
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141. Gene Expression Profiles from Formalin Fixed Paraffin Embedded Breast Cancer Tissue Are Largely Comparable to Fresh Frozen Matched Tissue

Author: Mittempergher, Lorenza, primary, de Ronde, Jorma J., additional, Nieuwland, Marja, additional, Kerkhoven, Ron M., additional, Simon, Iris, additional, Th. Rutgers, Emiel J., additional, Wessels, Lodewyk F. A., additional, and Van't Veer, Laura J., additional
Published: 2011
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142. Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer

Author: Salazar, Ramon, primary, Roepman, Paul, additional, Capella, Gabriel, additional, Moreno, Victor, additional, Simon, Iris, additional, Dreezen, Christa, additional, Lopez-Doriga, Adriana, additional, Santos, Cristina, additional, Marijnen, Corrie, additional, Westerga, Johan, additional, Bruin, Sjoerd, additional, Kerr, David, additional, Kuppen, Peter, additional, van de Velde, Cornelis, additional, Morreau, Hans, additional, Van Velthuysen, Loes, additional, Glas, Annuska M., additional, Van't Veer, Laura J., additional, and Tollenaar, Rob, additional
Published: 2011
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143. Do Rectal Cancer Patients with PIK3CA Mutations Benefit from Preoperative Radiotherapy with Regard to Local Recurrences?

Author: He, Youji, primary, Van't Veer, Laura J., additional, Lopez-Yurda, Marta, additional, van de Velde, Cornelis J.H., additional, and Marijnen, Corrie A.M., additional
Published: 2010
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144. Specific genomic aberrations in primary colorectal cancer are associated with liver metastases

Author: Bruin, Sjoerd C, primary, Klijn, Christiaan, additional, Liefers, Gerrit-Jan, additional, Braaf, Linde M, additional, Joosse, Simon A, additional, van Beers, Eric H, additional, Verwaal, Victor J, additional, Morreau, Hans, additional, Wessels, Lodewyk F, additional, van Velthuysen, Marie-Louise F, additional, Tollenaar, Rob AEM, additional, and van't Veer, Laura J, additional
Published: 2010
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145. Missense Variants in ATM in 26,101 Breast Cancer Cases and 29,842 Controls

Author: Fletcher, Olivia, primary, Johnson, Nichola, additional, dos Santos Silva, Isabel, additional, Orr, Nick, additional, Ashworth, Alan, additional, Nevanlinna, Heli, additional, Heikkinen, Tuomas, additional, Aittomäki, Kristiina, additional, Blomqvist, Carl, additional, Burwinkel, Barbara, additional, Bartram, Claus R., additional, Meindl, Alfons, additional, Schmutzler, Rita K., additional, Cox, Angela, additional, Brock, Ian, additional, Elliott, Graeme, additional, Reed, Malcolm W.R., additional, Southey, Melissa C., additional, Smith, Letitia, additional, Spurdle, Amanda B., additional, Hopper, John L., additional, Couch, Fergus J., additional, Olson, Janet E., additional, Wang, Xianshu, additional, Fredericksen, Zachary, additional, Schürmann, Peter, additional, Waltes, Regina, additional, Bremer, Michael, additional, Dörk, Thilo, additional, Devilee, Peter, additional, van Asperen, Christie J., additional, Tollenaar, Rob A.E.M., additional, Seynaeve, Caroline, additional, Hall, Per, additional, Czene, Kamila, additional, Humphreys, Keith, additional, Liu, Jianjun, additional, Ahmed, Shahana, additional, Dunning, Alison M., additional, Maranian, Melanie, additional, Pharoah, Paul D.P., additional, Chenevix-Trench, Georgia, additional, Beesley, Jonathan, additional, Bogdanova, Natalia V., additional, Antonenkova, Natalia N., additional, Zalutsky, Iosif V., additional, Anton-Culver, Hoda, additional, Ziogas, Argyrios, additional, Brauch, Hiltrud, additional, Ko, Yon-Dschun, additional, Hamann, Ute, additional, Fasching, Peter A., additional, Strick, Reiner, additional, Ekici, Arif B., additional, Beckmann, Matthias W., additional, Giles, Graham G., additional, Severi, Gianluca, additional, Baglietto, Laura, additional, English, Dallas R., additional, Milne, Roger L., additional, Benítez, Javier, additional, Arias, José Ignacio, additional, Pita, Guillermo, additional, Nordestgaard, Børge G., additional, Bojesen, Stig E., additional, Flyger, Henrik, additional, Kang, Daehee, additional, Yoo, Keun-Young, additional, Noh, Dong Young, additional, Mannermaa, Arto, additional, Kataja, Vesa, additional, Kosma, Veli-Matti, additional, García-Closas, Montserrat, additional, Chanock, Stephen, additional, Lissowska, Jolanta, additional, Brinton, Louise A., additional, Chang-Claude, Jenny, additional, Wang-Gohrke, Shan, additional, Broeks, Annegien, additional, Schmidt, Marjanka K., additional, van Leeuwen, Flora E., additional, Van't Veer, Laura J., additional, Margolin, Sara, additional, Lindblom, Annika, additional, Humphreys, Manjeet K., additional, Morrison, Jonathan, additional, Platte, Radka, additional, Easton, Douglas F., additional, and Peto, Julian, additional
Published: 2010
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146. Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells

Author: de Graauw, Marjo, primary, van Miltenburg, Martine H., additional, Schmidt, Marjanka K., additional, Pont, Chantal, additional, Lalai, Reshma, additional, Kartopawiro, Joelle, additional, Pardali, Evangelia, additional, Le Dévédec, Sylvia E., additional, Smit, Vincent T., additional, van der Wal, Annemieke, additional, Van't Veer, Laura J., additional, Cleton-Jansen, Anne-Marie, additional, ten Dijke, Peter, additional, and van de Water, Bob, additional
Published: 2010
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147. PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer

Author: Kok, Marleen, primary, Zwart, Wilbert, additional, Holm, Caroline, additional, Fles, Renske, additional, Hauptmann, Michael, additional, Van’t Veer, Laura J., additional, Wessels, Lodewyk F. A., additional, Neefjes, Jacques, additional, Stål, Olle, additional, Linn, Sabine C., additional, Landberg, Göran, additional, and Michalides, Rob, additional
Published: 2010
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148. Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer

Author: Tian, Sun, primary, Roepman, Paul, additional, van't Veer, Laura J, additional, Bernards, Rene, additional, De Snoo, Femke, additional, and Glas, Annuska M, additional
Published: 2010
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149. Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients

Author: Schmidt, Marjanka K, primary, Tommiska, Johanna, additional, Broeks, Annegien, additional, van Leeuwen, Flora E, additional, Van't Veer, Laura J, additional, Pharoah, Paul DP, additional, Easton, Douglas F, additional, Shah, Mitul, additional, Humphreys, Manjeet, additional, Dörk, Thilo, additional, Reincke, Scarlett A, additional, Fagerholm, Rainer, additional, Blomqvist, Carl, additional, and Nevanlinna, Heli, additional
Published: 2009
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150. PIK3CA Mutations Predict Local Recurrences in Rectal Cancer Patients

Author: He, Youji, primary, Van't Veer, Laura J., additional, Mikolajewska-Hanclich, Izabela, additional, van Velthuysen, Marie-Louise F., additional, Zeestraten, Eliane C.M., additional, Nagtegaal, Iris D., additional, van de Velde, Cornelis J.H., additional, and Marijnen, Corrie A.M., additional
Published: 2009
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