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Additional file 4: Supplementary Figure 3. Correlation between NF-M assays. (A) Correlation between HPA022845 and HPA023138 single-binder data. (B) Correlation between HPA022845 sandwich assays. HPA022845 was used as capture antibody together with two different detection antibodies, 20,664–1-AP and 13–0700. (C) Correlation between one HPA22845 sandwich assay and HPA023138 sandwich assay. HPA022845 was used as capture antibody together with 20,664–1-AP as detection antibody, and HPA023138 was used as capture antibody together with 34–1000 as detection antibody.

Additional file 1: Supplementary Table 1. List of 70 proteins included in statistical analysis. Sorted by p-value (lowest to highest). Supplementary Table 2.P-values of age effect from generalized linear models. Sorted by order of Table 2. Supplementary Table 3. Table of unadjusted p-values for group separations in the second cohort. Sorted by order of Table 2. Supplementary Table 4. Antibodies used for development of NF-M sandwich assay.

Additional file 2: Supplementary Figure 1. CSF levels of proteins in Table 2. Statistically significant differences (p-values) are found in Table 2. NC – Non-carriers, PMC – Presymptomatic mutation carriers, PPA – Primary progressive aphasia, bvFTD – Behavioural variant FTD.

Additional file 3: Supplementary Figure 2. Validation of NF-M antibody binding. (A) Detection of NF-M with HPA022845 as capture antibody and 20,664–1-AP as detection antibody. No cross-reactivity with antibodies targeting NF-L or NF-H was observed. (B) Detection of NF-M with HPA022845 as capture antibody and 13–0700 as detection antibody. No cross-reactivity with antibodies targeting NF-L or NF-H was observed. (C) Detection of NF-M with HPA023138 as capture antibody and 34–1000 as detection antibody. No cross-reactivity with antibodies targeting NF-L or NF-H was observed. (D-F) Comparison between sandwich assay data and single-binder data. Rho(D) = 0.85, p(D) = 1E− 7, rho(E) = 0.86, p(E) = 1E− 7, rho(F) = 0.82, p(F) = 1E− 6.

The liver X receptors Lxrα/NR1H3 and Lxrβ/NR1H2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mDA) neuron development. We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA neurogenesis in vitro In this study, we demonstrate that 24,25-EC promotes mDA neurogenesis in an Lxr-dependent manner in the developing mouse midbrain in vivo and also prevents toxicity induced by the Lxr inhibitor geranylgeranyl pyrophosphate. Furthermore, using MS, we show that overexpression of human cholesterol 24S-hydroxylase (CYP46A1) increases the levels of both 24(S)-hydroxycholesterol (24-HC) and 24,25-EC in the developing midbrain, resulting in a specific increase in mDA neurogenesis in vitro and in vivo, but has no effect on oculomotor or red nucleus neurogenesis. 24-HC, unlike 24,25-EC, did not affect in vitro neurogenesis, indicating that the neurogenic effect of 24,25-EC on mDA neurons is specific. Combined, our results indicate that increased levels of 24,25-EC in vivo, by intracerebroventricular delivery in WT mice or by overexpression of its biosynthetic enzyme CYP46A1, specifically promote mDA neurogenesis. We propose that increasing the levels of 24,25-EC in vivo may be a useful strategy to combat the loss of mDA neurons in Parkinson's disease. ispartof: J Biol Chem vol:294 issue:11 pages:4169-4176 ispartof: location:United States status: published

In this study we have analyzed sediment trap time series from five tropical sites to assess seasonal variations in concentrations and fluxes of long-chain diols (LCDs) and associated proxies with emphasis on the Long chain Diol Index (LDI). For the tropical Atlantic, we observe that generally less than 2 % of LCDs settling from the water column are preserved in the sediment. The Atlantic and Mozambique Channel traps reveal minimal seasonal variations in the LDI, similar to the TEX86 and UK´37. However, annual mean LDI-derived temperatures are in good agreement with the annual mean satellite-derived sea surface temperatures (SSTs). In the Cariaco Basin the LDI shows larger seasonal variation, as do the TEX86 and UK´37. Here, the LDI underestimates SST during the warmest months, which is likely due to summer stratification and the habitat depth of the diol producers deepening to around 20 to 30 m. Surface sediment LDI temperatures in the Atlantic and Mozambique Channel compare well with the average LDI-derived temperatures from the overlying sediment traps, as well as with decadal annual mean SST. Lastly, we observed large seasonal variations in the Diol Index, as indicator of upwelling conditions, at three sites, potentially linked to Guinea Dome upwelling (Eastern Atlantic), seasonal upwelling (Cariaco Basin) and seasonal upwelling and/or eddy migration (Mozambique Channel).

Bakgrund: Förvärv av bolag har sin grund i integration av verksamheter. För att skapa en effektiv integration krävs förståelse av den nyförvärvade verksamheten. Förmågan att förstå och identifiera utmaningar är avgörande om en integration leder till framgång eller misslyckande. One-stop-shopping som koncept erbjuder helhetslösningar och därmed stora artikelsortiment. Dock är det inte ekonomiskt försvarbart att hantera alla artiklar i sortimentet lika. Med förvärv av verksamhet breddas sortiment ytterligare och att differentiera artiklar blir ännu mer kritiskt. Artikelhantering innebär klassificering av artiklar efter dess betydelse för verksamheten. Artikelhantering motsvarar därför differentiering av sortiment och är en förutsättning för god lagerstyrning. Att göra ett nyförvärv av sortiment i samband med en integration effektiv står som grund i denna studie. Syfte: Studiens syfte är att utifrån identifierade utmaningar i Staples Branding Solutions inköpsprocess utveckla ett ramverk, vilket kan bidra till förbättrad artikelhantering av nyförvärvat sortiment. Frågeställningar: (1) Vilka utmaningar gällande artikelhantering av nyförvärvat sortiment kan identifieras i Staples Branding Solutions inköpsprocess?(2) Hur kan Staples Branding Solution utifrån identifierade utmaningar i inköpsprocessen skapa en förbättrad artikelhantering? Genomförande: Denna studie motsvarar en fallstudie på Staples Branding Solution. Empirisk data är insamlad genom semi- respektive strukturerade intervjuer samt genom kvantitativ data från fallstudieföretagets affärssystem. Målet med studien är att genom ett utvecklat ramverk åskådliggöra hur utmaningar vid förvärv, gällande överföring av artikelsortiment, kan hanteras på ett så effektivt sätt som möjligt utan att äventyra kunders behov. Slutsats: Genom flerkriterieanalysen ABC/XYZ kan företag som förvärvar en verksamhet skapa en helhetsbild över det tillkomna sortimentet. Detta trots informationsbrist och saknad av artikeldata. ABC/XYZ-analys skapar möjlighet för företag som befinner sig i likande situation som Staples Branding Solution att differentiera sortiment med avseende på volymvärde och uttagsfrekvens. Vilket skapar förutsättning att identifiera artiklar som är mer betydelsefulla för verksamheten. Detta underlättar vid resursfördelning, kontrollpunkter och kundservicedifferentiering.

Currents, wind, bathymetry, and freshwater runoff are some of the factors that make coastal waters heterogeneous, patchy, and scientifically interesting—where it is challenging to resolve the spatiotemporal variation within the water column. We present methods and results from field experiments using an autonomous underwater vehicle (AUV) with embedded algorithms that focus sampling on features in three dimensions. This was achieved by combining Gaussian process (GP) modeling with onboard robotic autonomy, allowing volumetric measurements to be made at fine scales. Special focus was given to the patchiness of phytoplankton biomass, measured as chlorophyll a (Chla), an important factor for understanding biogeochemical processes, such as primary productivity, in the coastal ocean. During multiple field tests in Runde, Norway, the method was successfully used to identify, map, and track the subsurface chlorophyll a maxima (SCM). Results show that the algorithm was able to estimate the SCM volumetrically, enabling the AUV to track the maximum concentration depth within the volume. These data were subsequently verified and supplemented with remote sensing, time series from a buoy and ship-based measurements from a fast repetition rate fluorometer (FRRf), particle imaging systems, as well as discrete water samples, covering both the large and small scales of the microbial community shaped by coastal dynamics. By bringing together diverse methods from statistics, autonomous control, imaging, and oceanography, the work offers an interdisciplinary perspective in robotic observation of our changing oceans. © 2019. This is the authors' accepted and refereed manuscript to the article. The final authenticated version is available online at: http://dx.doi.org/10.1126/scirobotics.aav3041

One-year long time series of current velocity and temperature from eight moorings deployed in the Faroe Bank Channel (FBC) are analysed to describe the structure and variability of the dense overflow plume on daily to seasonal timescales. Mooring arrays were deployed in two sections: located 25 km downstream of the main sill, in the channel that geographically confines the overflow plume at both edges (section C), and 60 km further downstream, over the slope (section S). At section C, the average volume transport of overflow waters ( −4 and (120 ± 43) × 10−4 m2 s−1, respectively.

Three years (2008–2011) of current measurements outside Pemba (∼13°S), Mozambique, are presented. Oil and gas reserves are found in the region, and knowledge of the ocean current climate is important for safe offshore operations. The full-depth current profile at Pemba was estimated by comparing with moorings further south. The moored record was also compared with geostrophic velocities obtained from sea surface height (SSH) fields, current profiles from ship-mounted Acoustic Doppler Current Profiler and surface currents from seven drifters passing the mooring. Velocities up to 60 cm/s were observed at 850 m depth. Altimetry-derived currents, while strong (often > 100 cm/s), are probably underestimates due to coarse resolution. Direct observations show surface currents up to 170 cm/s. Four strong current events were studied in detail. Three of the four events appeared to be associated with anticyclonic eddies nearby. The time series of SSH-derived geostrophic current always showed southward veloci...

In this study we examine how bilateral trade flows are affected by regime type. Previous research with the aim to investigate the effect of regime type on bilateral trade has primarily used a binary definition of democracy, and findings have indicated that democracies trade more extensively with other democracies. In this thesis, we add to the existing literature by disaggregating regime types, defining liberal democracies, electoral democracies and authoritarian regimes, and adopt the well-proven methodology of the gravity model of trade in OLS regressions. We use trade data adopted from IMF in the years 2004 and 2014 covering 162 countries. Data on the main explanatory variable, regime type, is defined in accordance with democracy indicator Freedom House’s methodology. Results show that pairs consisting of two liberal democracies have the highest values of trade flows, compared to other combinations of trading regime type-pairs. However, due to methodological discrepancies and ambiguous estimates, the relationship between regime type and trade flows remains uncertain.

Introduction Cancer affects not only the patient, but also the whole family, especially when a member of the family assumes the role of the family caregiver. This puts an additional emotional, social and financial strain on the family caregivers. Family caregivers of cancer patients are actively involved in the care provided at the home setting through various ways including practical tasks, symptom management and care coordination. The focus of preceding studies on family caregivers and symptom management was either on pain or the patients' and family caregivers' experience of symptom management and coping. The aim of this review was to provide evidence on how family caregivers manage symptoms and side effects at home, in adult cancer patients throughout the disease trajectory. Methods A systematic literature review was performed in PubMed, CINAHL, Web of Science and the Cochrane Central Register of Controlled Trials with a combination of keywords and MeSH terms for family caregivers, cancer, symptoms, side effects and management. Based on predetermined inclusion and exclusion criteria, a total of 1270 articles were screened and 20 studies were included in the analysis. A descriptive analysis was performed due to the heterogeneity of the findings. Results The results showed that only a limited number of studies (3/20) explored how and what family caregivers do in symptom management as a primary outcome. Family caregivers provided psychosocial support, such as supporting and motivating the patient and maintaining social engagement. Caregivers provided physical support such as with the administration of medicine and tube feeding. As an integral part of managing the symptoms, family caregivers actively monitored and assessed symptoms to timely recognize any treatment related side effects, assess the response to therapeutic interventions and recognize possible deterioration in physical status. Furthermore, family caregivers were often the decision maker – being alert, watching and waiting and decided when to act and when not to act. Conclusions Family caregivers are doing work similar to healthcare professionals, when managing symptoms and side effects at home in patients with cancer. Advanced tasks such as assessing, monitoring and deciding when and how to act are included in the daily routine of family caregivers.

The objective of the project was to develop new measurement technology for use in the ice edge zone. The unique marine ecosystem of the Arctic is sensitive to anthropogenic change, including acidification caused by CO2 emissions. Better knowledge of how this natural system functions is needed, but it is a challenging area to observe. In this project, a new sensor package measuring parameters relevant to ocean acidification was integrated on an autonomous sailing platform, the SailBuoy. A method of automatically identifying objects in echograms was developed. Objects seen in the echograms from the SailBuoy were categorized by their shape, and interpreted as plankton, individual fish or fish schools. The automatically identified and classified objects from the echograms were compared with satellite data and with the independently made measurements from the other SailBuoy. It is clear that using two SailBuoys with different instrumentation in tandem opens up interesting possibilities., NERSC Technical Report no. 395. Funded by the Research Council of Norway, grant no. 78894

Factors related to hospital length of stay, re-admissions and unplanned care for patients with cancer, an on-going study

[1] The narrow and deep Faroe Bank Channel (FBC) is an important pathway for cold, dense waters from the Nordic Seas to flow across the Iceland-Scotland ridge into the North Atlantic. The swift, turbulent FBC overflow is associated with strong vertical mixing. Hydrographic profiles from a shipboard survey and two Slocum electric gliders deployed during a cruise in May–June 2012 show an intermediate water mass characterized by low salinity and low oxygen concentration between the upper waters of Atlantic origin and the dense overflow water. A weak low-salinity signal originating north-east of Iceland is discernible at the exit of the FBC, but smeared out by intense mixing. Further west (downstream) marked salinity and oxygen minima are found, which we hypothesize are indicators of a mixture of Labrador Sea Water and Intermediate Water from the Iceland Basin. Water mass characteristics vary strongly on short time scales. Low-salinity, low-oxygen water in the stratified interface above the overflow plume is shown to move along isopycnals toward the Iceland-Faroe Front as a result of eddy stirring and a secondary, transverse circulation in the plume interface. The interaction of low-salinity, low-oxygen intermediate waters with the overflow plume already at a short distance downstream of the sill, here reported for the first time, affects the final properties of the overflow waters through entrainment and mixing.

Observations of hydrography, currents, and microstructure are presented together with sea surface height (SSH) patterns from concurrent satellite tracks to describe the subinertial oscillations in the region downstream of the Faroe Bank Channel overflow. Energetic oscillations with a dominant 3–5-day period have previously been observed in the dense bottom layer and found to be consistent with topographic Rossby waves. Here, the authors present evidence that the oscillations extend over the whole water column and are connected to a wave-like pattern in SSH along the continental slope. The waves are observed in two satellite tracks running parallel to the slope and indicate a wavelength of 50–75 km, an amplitude of about 5 cm, and a phase speed of 15–20 cm s−1. The pattern extends at least 450 km along the slope. Repeat occupations of a section through a 4-day period show a barotropic velocity anomaly that is associated with an increase in plume transport [from 0.5 to 2.5 Sv (1 Sv ≡ 106 m3 s−1)] and interface height (from 100 to 200 m) as well as changes in dissipation rates and mixing. Estimates of entrainment velocity wE vary with a factor of 102 over the oscillation period, and there is an inverse relation between wE and plume thickness, that is, mixing is most intense when the dense bottom layer is thin. High values of wE coincide with a large percentage of critical Richardson numbers in the interfacial layer. The rotational motion, or the horizontal “stirring,” is observed to bring water from the south, traceable because of its low oxygen concentrations, into the plume.

Bakgrund : Delaktighet och personcentrerad vård är centrala begrepp i den vård som bedrivs idag. För att patienten ska vara delaktig krävs det att patienten är mer involverad i de dagliga händelserna som till exempel skiftrapportering. Vid varje skiftbyte sker överrapportering från en sjuksköterska till en annan, överrapporteringarna saknar ofta patientmedverkan. En rapporteringsmodell är bedsiderapportering vilket innebär att rapporteringen sker i patientens närvaro. Syfte : Syftet var att beskriva patientens delaktighet i vården vid bedsiderapportering. Metod : En litteraturöversikt. Resultat : Bedsiderapportering fick patienterna att känna sig delaktiga i vården, vilket delvis berodde på att de kände sig som värdefulla deltagare. Patienterna betraktades i första hand som en person. Både patienter och sjuksköterskor ansåg att rapporteringssättet var avgörande för patientens delaktighet i vården. De flesta patienter uppskattade att få vara med i rapporteringen och få viktig information som de ansåg sig ha rätt till. Dock ville inte alla patienter delta, vilket bland annat berodde på att rapporten ansågs vara till för sjuksköterskor. Slutsats : Bedsiderapportering ökade patientens delaktighet i vården enligt både patienten och sjuksköterskan. Dock ville inte alla patienter delta i rapporteringen och graden av delaktighet var beroende av på vilket sätt rapporten gavs. Background : Participation and person-centered care are key concepts in the care that are being given today. In order for the patient to participate, they must be involved in the daily work such as shift reporting. At each shift, reporting occurs from one nurse to another which often lacks patient involvement. A reporting model is bedside report, which means reporting takes place in the patient's presence. Aim : The aim of this study was to describe patient’s participation in care during bedside report. Method : A literature review. Results : Bedside report made patients feel more involved in their care, partly because they felt valued as a participant in the report. The patients were considered a person in the first hand. Both patients and nurses felt that the reporting method was crucial for the participation. Most patients appreciated being included in the reporting and that they received valuable information that they considered justifiable. However, not all patients wanted to participate, which was due, among other things, to the fact that the report was considered for the nurses. Conclusion : Bedside report increased patient involvement in care, according to both the patient and the nurse. However, not all patients wanted to participate and the reporting method were important for the level of participation.

The South Equatorial Current (SEC) in the Indian Ocean bifurcates when it reaches Madagascar leading, respectively, to the North East Madagascar Current (NEMC), which contours the island flowing northwestward, and to the South East Madagascar Current (SEMC), which flows southwestward. Both branches eventually contribute to the greater Agulhas Current system and thus play a part in the global ocean circulation. In addition, these currents have important effects on the local conditions for marine life. In this study, the NEMC and the SEMC are investigated based on a comprehensive, multidisciplinary survey of the east coast of Madagascar in 2008. Results from conductivity-temperaturedepth stations, underway measurements with thermosalinograph and fluorometer, and ship-mounted acoustic Doppler current profiler are discussed along with concomitant remotely sensed data. Maximum core velocities of >150 cm s–1 were observed in both the NEMC and the SEMC. The SEMC appeared as a nearshore southward jet, which extended at its widest nearly 200 km offshore. Near the southern tip of Madagascar, the SEMC was flanked by reverse velocities: a northeastward current about 30 km wide along the coast and a northeastward offshore current greater than 140 km wide suggesting the presence of the South Indian Ocean Countercurrent. The NEMC had the structure of a narrow nearshore jet, with weak currents beyond 100 km offshore. Volume transport for the upper 1,100 m was estimated to be 22 Sverdrup (Sv) for the SEMC and 48 Sv for the NEMC. The high NEMC transport compared with earlier estimates might be because of anomalously high influx of the SEC during the measurement period. Off the south coast, an undercurrent below 900 m carried an equatorward transport of 3.1 Sv. No undercurrent was observed in the north, but a geostrophic velocity minimum and a similar vertical velocity shear between surface and subsurface currents were found at the level where such a countercurrent has been previously observed from direct measurements.

Bakgrund : Delaktighet och personcentrerad vård är centrala begrepp i den vård som bedrivs idag. För att patienten ska vara delaktig krävs det att patienten är mer involverad i de dagliga händelserna som till exempel skiftrapportering. Vid varje skiftbyte sker överrapportering från en sjuksköterska till en annan, överrapporteringarna saknar ofta patientmedverkan. En rapporteringsmodell är bedsiderapportering vilket innebär att rapporteringen sker i patientens närvaro. Syfte : Syftet var att beskriva patientens delaktighet i vården vid bedsiderapportering. Metod : En litteraturöversikt. Resultat : Bedsiderapportering fick patienterna att känna sig delaktiga i vården, vilket delvis berodde på att de kände sig som värdefulla deltagare. Patienterna betraktades i första hand som en person. Både patienter och sjuksköterskor ansåg att rapporteringssättet var avgörande för patientens delaktighet i vården. De flesta patienter uppskattade att få vara med i rapporteringen och få viktig information som de ansåg sig ha rätt till. Dock ville inte alla patienter delta, vilket bland annat berodde på att rapporten ansågs vara till för sjuksköterskor. Slutsats : Bedsiderapportering ökade patientens delaktighet i vården enligt både patienten och sjuksköterskan. Dock ville inte alla patienter delta i rapporteringen och graden av delaktighet var beroende av på vilket sätt rapporten gavs. Background : Participation and person-centered care are key concepts in the care that are being given today. In order for the patient to participate, they must be involved in the daily work such as shift reporting. At each shift, reporting occurs from one nurse to another which often lacks patient involvement. A reporting model is bedside report, which means reporting takes place in the patient's presence. Aim : The aim of this study was to describe patient’s participation in care during bedside report. Method : A literature review. Results : Bedside report made patients feel more involved in their care, partly because they felt valued as a participant in the report. The patients were considered a person in the first hand. Both patients and nurses felt that the reporting method was crucial for the participation. Most patients appreciated being included in the reporting and that they received valuable information that they considered justifiable. However, not all patients wanted to participate, which was due, among other things, to the fact that the report was considered for the nurses. Conclusion : Bedside report increased patient involvement in care, according to both the patient and the nurse. However, not all patients wanted to participate and the reporting method were important for the level of participation.

Purpose: The primary aim was to describe patients with Head and Neck (H&N) cancer referred to palliative care and how the care transition from acute oncological to palliative care impacted on both Health related quality of life (HRQoL) and information. The secondary aim was to explore H&N cancer patients' HRQoL and perceived information. Methods: H&N cancer patients were identified via the Swedish Cancer Register. Data were collected using the following questionnaires; European Organization for Research and Treatment of Cancer (EORTC) QLQ C-30, INFO25, and a study-specific questionnaire. Key results: Out of 289 patients, 203 (70%) responded and among these, 43 (21%) reported being referred to palliative care. Global health was the lowest reported functional scale (median score = 67) and fatigue (median scores 33) the highest reported symptom (QLQ C-30). Patients with a written care plan were significantly more satisfied with information regarding self-care compared to patients without a care plan. Patients referred to palliative care were less satisfied with information regarding disease (p < 0.000), the spread of the disease (p < 0.001) and were more likely to visit hospital emergency departments (43% vs. 19% p < 0.000). Conclusion: To avoid H&N cancer care in silos, a closer integration between the oncology and the palliative care team is needed. Further research on the complex situation of having oncological treatment concurrent with palliative care, is needed.

Introduction: Cancer affects the patients and the whole family, especially when a member of the family assumes the role of the family caregiver. Family Caregivers (FCGs) of cancer patients are actively engaging in multiple tasks, for example coordination and symptom management. The focus of most studies on FCGs and symptom management in the past, are mainly on FCGs experience and coping, not how or whatthey do.The aim of this systematic review was to provide evidence on how FCGs manage symptoms and side-effects at home, in adult cancer patients throughout the disease trajectory.Methods: A search in PubMed, CINAHL, Web of Science and the Cochrane Central Register of Controlled Trials was performed with a combination of keywords and MeSH terms for informal caregivers, cancer, symptoms, side-effects and management. A total of 1270 articles were screened for inclusion and 20 studies were included in the analysis. A descriptive analysis was performed due to the heterogeneity of the findings.Results: FCGs were doing emotional work, such as supporting and motivating the patient, and physically helping the patients, for example with administration of medicine. Monitoring and assessing symptoms were also frequently reported. Further, FCGs were the decision maker u2013 being alert, watching and waiting and decided when to act and when not to act.Conclusions: FCGs are doing work similar to healthcare professionals, when managing symptoms and side-effects at home. Advanced tasks such as assessing, monitoring and deciding when and how to act are included in the daily routine of FCGs.

Introducing a Digital Individual Care plan in Head and Neck cancer- barriers and facilitatorsH. Ullgren1,2,31Karolinska Universtiy Hospital, Oncology, Stockholm, Sweden2Regional Cancer Center, Coordinating Contact nurse, Stockholm-Gotland, Sweden3Umeu00e5 University, Nursing, Umeu00e5, Sweden Introduction:Patients with Head & Neck (H&N) cancer often have a complex care trajectory. The Swedish National Cancer plan states that all patients should receive an individual written care plan (IWCP). The IWCP should be done together with the patient containing what is important from both Health care provider (HCP) and patient perspective.Until recently the IWCP, constituted of an information booklet, and the patient treatment plan in the medical records.Methods:All patients with H&N cancer may choose a standard IWCP or the digital format. The digital IWCP is prepared by the contact nurse (CN). The patients can interact with the CN and also send a NRS scale over different symptoms as well as rehabilitation tool. This quality development project is evaluated by an independent CN, with interviewing both the involved patients and CN involved.Results:Evaluation of this project is currently undergoing, 10 patients are interviewed so far. Since started 25% of patients prefer a digital IWCP, and patients offer many suggestions for improvement. The CNsu00b4 involved assess the digital IWCP as easy, less time consuming and more suited to personalize compared with the book leaflet. The evaluation suggest a greater patient participation.Conclusions:One enabler for implementation is that the platform is chosen through a national consensus and the HCP and patients may influence the design. Not all patients want a digital version when a paper version is offered. There is a potential for increased use of screening tools and systematic assessment of symptoms with the digital version of the IWCP.