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849 results on '"Uchida, Kazushige"'

101. Clinical implications of elevated serum interleukin-6 in IgG4-related disease

Author

Tsukuda, Satoshi, primary, Ikeura, Tsukasa, additional, Ito, Takashi, additional, Nakamaru, Koh, additional, Masuda, Masataka, additional, Hori, Yuichi, additional, Ikemune, Manami, additional, Yanagawa, Masato, additional, Tanaka, Toshihiro, additional, Tomiyama, Takashi, additional, Yamaguchi, Takashi, additional, Ando, Yugo, additional, Uchida, Kazushige, additional, Fukui, Toshiro, additional, Nishio, Akiyoshi, additional, Terasawa, Rika, additional, Tanigawa, Noboru, additional, and Okazaki, Kazuichi, additional

Published
2020
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105. Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis

Author

Yanagawa, Masato, Uchida, Kazushige, Ando, Yugo, Tomiyama, Takashi, Yamaguchi, Takashi, Ikeura, Tsukasa, Fukui, Toshiro, Nishio, Akiyoshi, Uemura, Yoshiko, Miyara, Takayuki, Okamoto, Hiroyuki, Satoi, Souhei, and Okazaki, Kazuichi

Subjects
parasitic diseases, chemical and pharmacologic phenomena, hemic and immune systems
Abstract

平成29年度, Background: Pathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. In this study, we investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP. Methods: By using immunohistochemistry, we investigated basophils in pancreatic tissue from 13 patients with type 1 AIP and examined expression of toll-like receptors (TLRs) by these cells. Additionally, we obtained peripheral blood samples from 27 healthy subjects, 40 patients with type 1 AIP, 8 patients with alcoholic chronic pancreatitis, 10 patients with bronchial asthma, and 10 patients with atopic dermatitis, and analyzed activation of basophils by stimulating them with ligands of TLR1-9. We also compared TLR expression in basophils from the tissue and blood samples. Results: Basophils were detected in pancreatic tissues from 10 of 13 patients with type 1 AIP. Flow cytometric analysis revealed that the ratios of basophils activated by TLR4 stimulation in type 1 AIP (9.875 ± 1.148%) and atopic dermatitis (11.768 ± 1.899%) were significantly higher than those in healthy subjects (5.051 ± 0.730%; P < 0.05). Levels of basophils activated by TLR2 stimulation were higher in seven type 1 AIP cases. Furthermore, stimulation of TLR2 and/or TLR4, which were expressed by basophils in pancreas, activated basophils in peripheral blood. Conclusions: Basophils activated via TLR signaling may play an important role in the pathophysiology of type 1 AIP.

Published
2017

119. IgG4-related disease in the Japanese population: a genome-wide association study

Author

Terao, Chikashi, primary, Ota, Masao, additional, Iwasaki, Takeshi, additional, Shiokawa, Masahiro, additional, Kawaguchi, Shuji, additional, Kuriyama, Katsutoshi, additional, Kawaguchi, Takahisa, additional, Kodama, Yuzo, additional, Yamaguchi, Izumi, additional, Uchida, Kazushige, additional, Higasa, Koichiro, additional, Yamamoto, Motohisa, additional, Kubota, Kensuke, additional, Yazumi, Shujiro, additional, Hirano, Kenji, additional, Masaki, Yasufumi, additional, Maguchi, Hiroyuki, additional, Origuchi, Tomoki, additional, Matsui, Shoko, additional, Nakazawa, Takahiro, additional, Shiomi, Hideyuki, additional, Kamisawa, Terumi, additional, Hasebe, Osamu, additional, Iwasaki, Eisuke, additional, Inui, Kazuo, additional, Tanaka, Yoshiya, additional, Ohshima, Koh-ichi, additional, Akamizu, Takashi, additional, Nakamura, Shigeo, additional, Nakamura, Seiji, additional, Saeki, Takako, additional, Umehara, Hisanori, additional, Shimosegawa, Tooru, additional, Mizuno, Nobumasa, additional, Kawano, Mitsuhiro, additional, Azumi, Atsushi, additional, Takahashi, Hiroki, additional, Mimori, Tsuneyo, additional, Kamatani, Yoichiro, additional, Okazaki, Kazuichi, additional, Chiba, Tsutomu, additional, Kawa, Shigeyuki, additional, Matsuda, Fumihiko, additional, Kanno, Atsushi, additional, Okabe, Yoshihiro, additional, Katsushima, Shinji, additional, Inokuma, Tetsuro, additional, Yamashita, Yukitaka, additional, Nakai, Yoshitaka, additional, Nishino, Takayoshi, additional, Kajimura, Kozo, additional, Shibatoge, Mitsushige, additional, Kanda, Naoki, additional, Ido, Akio, additional, Ohana, Masaya, additional, Moriyama, Ichiro, additional, Tatsuta, Hiroshi, additional, Matsumura, Kazuyoshi, additional, Fujikawa, Keita, additional, Gotoh, Norimoto, additional, Tsutsumi, Takanobu, additional, Shimizu, Masakazu, additional, Setoh, Kazuya, additional, Takahashi, Meiko, additional, Tabara, Yasuharu, additional, Mimura, Jun, additional, Nakamura, Takefumi, additional, Kimura, Toshiyuki, additional, and Kawanami, Chiharu, additional

Published
2019
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120. Diffuse Pancreatic Cancer Mimicking Autoimmune Pancreatitis

Author

Miyoshi, Hideaki, primary, Kano, Masataka, additional, Kobayashi, Sanshiro, additional, Ito, Takashi, additional, Masuda, Masataka, additional, Mitsuyama, Toshiyuki, additional, Nakayama, Shinji, additional, Ikeura, Tsukasa, additional, Shimatani, Masaaki, additional, Uchida, Kazushige, additional, Takaoka, Makoto, additional, and Okazaki, Kazuichi, additional

Published
2019
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123. FRI0621 ASSOCIATIONS BETWEEN ORGAN INVOLVEMENTS AND GENDER, ALLERGY, AND MALIGNANCY IN 166 PATIENTS WITH IGG4-RELATED DISEASE

Author

Yoshifuji, Hajime, primary, Shirakashi, Mirei, additional, Kodama, Yuzo, additional, Chiba, Tsutomu, additional, Yamamoto, Motohisa, additional, Takahashi, Hiroki, additional, Uchida, Kazushige, additional, Okazaki, Kazuichi, additional, Ito, Tetsuya, additional, Kawa, Shigeyuki, additional, Yamada, Kazunori, additional, Kawano, Mitsuhiro, additional, Hirata, Shintaro, additional, Tanaka, Yoshiya, additional, Moriyama, Masafumi, additional, Nakamura, Seiji, additional, Kamisawa, Terumi, additional, Matsui, Shoko, additional, Tsuboi, Hiroto, additional, Sumida, Takayuki, additional, Shibata, Motoko, additional, Goto, Hiroshi, additional, Sato, Yasuharu, additional, Yoshino, Tadashi, additional, and Mimori, Tsuneyo, additional

Published
2019
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125. Innovative marking method using novel endoscopic clip equipped with fluorescent resin to locate gastric cancer.

Author

Namikawa, Tsutomu, Hashiba, Motoi, Kitagawa, Hiroyuki, Mizuta, Hiroshi, Uchida, Kazushige, Sato, Takayuki, Kobayashi, Michiya, and Hanazaki, Kazuhiro

Subjects
STOMACH cancer, SURGICAL margin, INDOCYANINE green, DIGESTIVE system endoscopic surgery, GASTRECTOMY, PROFESSIONAL-student relations
Abstract

An asymptomatic 76‐year‐old man presented to our department for the treatment of gastric cancer. Esophagogastroduodenoscopy revealed a superficial elevated lesion with an irregular central depression in the lower third of the stomach; this was confirmed to be adenocarcinoma by biopsy, while abdominal contrast‐enhanced CT revealed no abnormal lesions. Based on the patient's clinical diagnosis of early gastric cancer, we planned laparoscopic gastrectomy with preoperative placement of four endoscopic marking clips equipped with indocyanine green‐conjugated resin to determine the resection margin. During surgery, a dedicated laparoscopic system was used to detect indocyanine green fluorescence emitted by the clips and determine their precise position. The clips helped to identify an accurate resection line for the stomach, enabling accurate laparoscopic distal gastrectomy with regional lymphadenectomy. We successfully demonstrated the usefulness of clips with fluorescent resin for detecting gastric cancer in patients. We report the first case using the clips to accurately locate a site of interest. [ABSTRACT FROM AUTHOR]

Published
2021
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128. Factors in glucocorticoid regimens associated with treatment response and relapses of IgG4-related disease: a multicentre study

Author

10934367, 20422975, Shirakashi, Mirei, Yoshifuji, Hajime, Kodama, Yuzo, Chiba, Tsutomu, Yamamoto, Motohisa, Takahashi, Hiroki, Uchida, Kazushige, Okazaki, Kazuichi, Ito, Tetsuya, Kawa, Shigeyuki, Yamada, Kazunori, Kawano, Mitsuhiro, Hirata, Shintaro, Tanaka, Yoshiya, Moriyama, Masafumi, Nakamura, Seiji, Kamisawa, Terumi, Matsui, Shoko, Tsuboi, Hiroto, Sumida, Takayuki, Shibata, Motoko, Goto, Hiroshi, Sato, Yasuharu, Yoshino, Tadashi, Mimori, Tsuneyo, 10934367, 20422975, Shirakashi, Mirei, Yoshifuji, Hajime, Kodama, Yuzo, Chiba, Tsutomu, Yamamoto, Motohisa, Takahashi, Hiroki, Uchida, Kazushige, Okazaki, Kazuichi, Ito, Tetsuya, Kawa, Shigeyuki, Yamada, Kazunori, Kawano, Mitsuhiro, Hirata, Shintaro, Tanaka, Yoshiya, Moriyama, Masafumi, Nakamura, Seiji, Kamisawa, Terumi, Matsui, Shoko, Tsuboi, Hiroto, Sumida, Takayuki, Shibata, Motoko, Goto, Hiroshi, Sato, Yasuharu, Yoshino, Tadashi, and Mimori, Tsuneyo

Abstract

Glucocorticoids (GC) are effective for treating IgG4-related disease (IgG4-RD); however, relapse is often observed. We conducted a retrospective multicentre study to investigate risk factors in GC regimens associated with relapses of IgG4-RD. Data on 166 patients with definitive IgG4-RD diagnosis were collected from 12 institutions. Comprehensive surveillance of clinical backgrounds and GC regimens as well as multivariate analysis of factors associated with treatment responses and relapses was performed. To determine the initial maximal GC dose, the patients were stratified into three groups depending on the initial prednisolone (PSL) dosage: <0.39, 0.4–0.69 and >0.7 mg/kg/day. The multivariate analysis extracted the disease duration and reduction speed of initial GC dose. Patients treated with initial GC <0.39 or >0.7 mg/kg/day of PSL showed higher relapse rates than those treated with 0.4–0.69 mg/kg/day. The relapse rates were significantly higher in patients with fast reduction of the initial dose (>0.4 mg/day) than in patients with slow reduction (<0.4 mg/day). To avoid relapse, 0.4–0.69 mg/kg/day of initial PSL with slow reduction speed (<0.4 mg/day) is needed in the early treatment of IgG4-RD.

Published
2018

133. Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016.

Author

Masamune, Atsushi, Kikuta, Kazuhiro, Hamada, Shin, Tsuji, Ichiro, Takeyama, Yoshifumi, Shimosegawa, Tooru, Okazaki, Kazuichi, Collaborators, Kanno, Atsushi, Sano, Takanori, Uchida, Kazushige, Ikeura, Tsukasa, Fujimori, Nao, Nakai, Yousuke, Kamisawa, Terumi, Kubota, Kensuke, Motoya, Masayo, Shimizu, Kyoko, Ushijima, Tomoyuki, and Fukasawa, Mitsuharu

Subjects
PANCREATITIS, PANCREATIC cysts, PANCREATIC cancer, PATIENT surveys, SEX ratio
Abstract

Background: To further clarify the clinico-epidemiological features of autoimmune pancreatitis (AIP) in Japan, we conducted the fourth nationwide epidemiological survey.Methods: This study consisted of two stage surveys; the number of AIP patients was estimated by the first survey and their clinical features were assessed by the second survey. We surveyed the AIP patients who had visited hospitals in 2016.Results: The estimated number of AIP patients in 2016 was 13,436, with an overall prevalence rate of 10.1 per 100,000 persons. The estimated number of newly diagnosed patients was 3984, with an annual incidence rate of 3.1 per 100,000 persons. Compared to the 2011 survey, both numbers more than doubled. We obtained detailed clinical information of 1474 AIP patients. The male-to-female sex ratio was 2.94, the mean age was 68.1, and mean age at diagnosis was 64.8. At diagnosis, 63% patients were symptomatic and nearly half of them presented jaundice. Pancreatic cysts were found in 9% of the patients and calcifications in 6%. Histopathological examination was performed in 64%, mainly by endoscopic ultrasonography-guided fine needle aspiration. Extra-pancreatic lesions were detected in 60% of the patients. Eighty-four % patients received the initial steroid therapy, and 85% received maintenance steroid therapy. Kaplan-Meier analysis revealed that the relapsed survival was 14% at 3 years, 25% at 5 years, 40% at 10 years, and 50% at 15 years. Mortality was favorable, but pancreatic cancer accounted for death in one quarter of fatal cases.Conclusion: We clarified the current status of AIP in Japan. [ABSTRACT FROM AUTHOR]

Published
2020
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137. Clinical course of type 1 autoimmune pancreatitis patients without steroid treatment: a Japanese multicenter study of 97 patients

Author

Kubota, Kensuke, primary, Kamisawa, Terumi, additional, Hirano, Kenji, additional, Hirooka, Yoshiki, additional, Uchida, Kazushige, additional, Ikeura, Tsukasa, additional, Shiomi, Hideyuki, additional, Ohara, Hirotaka, additional, Shimizu, Kyoko, additional, Arakura, Norikazu, additional, Kanno, Atsushi, additional, Sakagami, Junichi, additional, Itoi, Takao, additional, Ito, Tetsuhide, additional, Ueki, Toshiharu, additional, Nishino, Takayoshi, additional, Inui, Kazuo, additional, Mizuno, Nobumasa, additional, Yoshida, Hitoshi, additional, Sugiyama, Masanori, additional, Iwasaki, Eisuke, additional, Irisawa, Atsushi, additional, Okazaki, Kazuichi, additional, Kawa, Shigeyuki, additional, Shimosegawa, Toru, additional, Takeyama, Yoshifumi, additional, and Chiba, Tsutomu, additional

Published
2018
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139. Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey

Author

Notohara, Kenji, primary, Kamisawa, Terumi, additional, Uchida, Kazushige, additional, Zen, Yoh, additional, Kawano, Mitsuhiro, additional, Kasashima, Satomi, additional, Sato, Yasuharu, additional, Shiokawa, Masahiro, additional, Uehara, Takeshi, additional, Yoshifuji, Hajime, additional, Hayashi, Hiroko, additional, Inoue, Koichi, additional, Iwasaki, Keisuke, additional, Kawano, Hiroo, additional, Matsubayashi, Hiroyuki, additional, Moritani, Yukitoshi, additional, Murakawa, Katsuhiko, additional, Oka, Yoshio, additional, Tateno, Masatoshi, additional, Okazaki, Kazuichi, additional, and Chiba, Tsutomu, additional

Published
2017
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142. Sclerosing Esophagitis with IgG4-positive Plasma Cell Infiltration

Author

Mori, Shigeo, primary, Tahashi, Yoshiya, additional, Uchida, Kazushige, additional, Ikeura, Tsukasa, additional, Danbara, Naoyuki, additional, Wakamatsu, Takahiro, additional, Kusuda, Takeo, additional, Takahashi, Yu, additional, Yanagawa, Masato, additional, Matsushita, Mitsunobu, additional, Ohe, Chisato, additional, Michiura, Taku, additional, Inoue, Kentaro, additional, Kon, Masanori, additional, and Okazaki, Kazuichi, additional

Published
2017
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143. Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis

Author

Masamune, Atsushi, primary, Nishimori, Isao, additional, Kikuta, Kazuhiro, additional, Tsuji, Ichiro, additional, Mizuno, Nobumasa, additional, Iiyama, Tatsuo, additional, Kanno, Atsushi, additional, Tachibana, Yuichi, additional, Ito, Tetsuhide, additional, Kamisawa, Terumi, additional, Uchida, Kazushige, additional, Hamano, Hideaki, additional, Yasuda, Hiroaki, additional, Sakagami, Junichi, additional, Mitoro, Akira, additional, Taguchi, Masashi, additional, Kihara, Yasuyuki, additional, Sugimoto, Hiroyuki, additional, Hirooka, Yoshiki, additional, Yamamoto, Satoshi, additional, Inui, Kazuo, additional, Inatomi, Osamu, additional, Andoh, Akira, additional, Nakahara, Kazuyuki, additional, Miyakawa, Hiroyuki, additional, Hamada, Shin, additional, Kawa, Shigeyuki, additional, Okazaki, Kazuichi, additional, and Shimosegawa, Tooru, additional

Published
2016
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145. Analysis of neutrophil infiltration in Type 1 and Type 2 autoimmune pancreatitis

Author

Uchida, Kazushige, primary, Mitsuyama, Toshiyuki, additional, Yanagawa, Masato, additional, Miyoshi, Hideaki, additional, Ikea, Tsukasa, additional, Shimatani, Masaaki, additional, Fukui, Toshiro, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, Mizuno, Nobumasa, additional, Notohara, Kenji, additional, Zamboni, Giuseppe, additional, Frulloni, Luca, additional, Shimosegawa, Tooru, additional, and Okazaki, Kazuichi, additional

Published
2016
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