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103 results on '"Tsugeno, Hirofumi"'

101. A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants.

Author

Ishiguro M, Takenaka R, Ogura K, Hiratsuka A, Takeda H, Kawai D, Tsugeno H, Fujiki S, and Okada H

Subjects
Antimetabolites, Antineoplastic administration & dosage, Contraindications, Drug, Fatal Outcome, Fluorouracil administration & dosage, Humans, Male, Middle Aged, Adenocarcinoma drug therapy, Antimetabolites, Antineoplastic adverse effects, Dihydropyrimidine Dehydrogenase Deficiency diagnosis, Fluorouracil adverse effects, Stomach Neoplasms drug therapy
Abstract

A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2020
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102. Monopolar soft-mode coagulation using hemostatic forceps for peptic ulcer bleeding.

Author

Yamasaki Y, Takenaka R, Nunoue T, Kono Y, Takemoto K, Taira A, Tsugeno H, and Fujiki S

Subjects
Adult, Aged, Electrocoagulation instrumentation, Female, Humans, Male, Middle Aged, Surgical Instruments, Electrocoagulation methods, Peptic Ulcer Hemorrhage surgery
Abstract

Background/aims: Upper gastrointestinal hemorrhage from bleeding peptic ulcer is sometimes difficult to treat by conventional endoscopic methods. Recently, monopolar electrocoagulation using a soft-coagulation system and hemostatic forceps (soft coagulation) has been used to prevent bleeding during endoscopic submucosal dissection. The aim of this study was to assess the safety and efficacy of soft coagulation in the treatment of bleeding peptic ulcer., Methodology: A total of 39 patients with peptic ulcers were treated using soft coagulation at our hospital between January 2005 and March 2010. Emergency treatment employed an ERBE soft-mode coagulation system using hemostatic forceps. Second-look endoscopy was performed to evaluate the efficacy of prior therapy. Initial hemostasis was defined as accomplished by soft coagulation, with or without other endoscopic therapy prior to soft coagulation. The rate of initial hemostasis, rebleeding, and ultimate hemostasis were retrospectively analyzed., Results: The study subjects were 31 men and 8 women with a mean age of 68.3±13.7 years, with 29 gastric ulcers and 10 duodenal ulcers. Initial hemostasis was achieved in 37 patients (95%). During follow-up, bleeding recurred in two patients, who were retreated with soft coagulation., Conclusions: The monopolar soft coagulation is feasible and safe for treating bleeding peptic ulcers.

Published
2014

103. [The impact of guidelines for the management of acute cholecystitis in a rural area of Japan].

Author

Yamasaki Y, Takenaka R, Okazaki N, Baba Y, Hamada K, Takayama H, Takemoto K, Taira A, Tsugeno H, Kubota Y, Hayashi D, and Fujiki S

Subjects
Adult, Aged, Aged, 80 and over, Cholecystectomy, Cholecystitis, Acute complications, Female, Gallstones complications, Humans, Japan, Male, Middle Aged, Rural Health, Cholecystitis, Acute surgery, Practice Guidelines as Topic
Abstract

We monitored the management of acute cholecystitis in a rural area of Japan to determine the effectiveness of new guidelines for the management of acute cholecystitis and cholangitis. Between January 2000 and September 2011, 366 patients were treated for acute cholecystitis. Of these, 59 had common bile duct stones (CBDS) and 307 did not. Patients in both groups were further subdivided into two groups: a before guidelines group (BGG; n=153) and an after guideline group (AGG; n=154). Among the patients without CBDS, early cholecystectomy was more common in the AGG group (n=53) than in the BGG group. Furthermore, the length of hospital stay was four days shorter in the AGG group than in the BGG group (n=23). Among the patients with CBDS, the timing of cholecystectomy after endoscopic retrograde cholangiography was seven days earlier in the AGG group than in the BGG group. Even in a rural area of Japan, early cholecystectomy appears safe and can decrease the length of hospital stay.

Published
2013

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