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106. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies

Author

Marklund, Matti, Wu, Jason H.Y., Imamura, Fumiaki, Del Gobbo, Liana C., Fretts, Amanda, de Goede, Janette, Shi, Peilin, Tintle, Nathan, Wennberg, Maria, Aslibekyan, Stella, Chen, Tzu-An, de Oliveira Otto, Marcia C., Hirakawa, Yoichiro, Eriksen, Helle Højmark, Kröger, Janine, Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Prem, Kiesha, Samieri, Cécilia, Virtanen, Jyrki, Wood, Alexis C., Wong, Kerry, Yang, Wei-Sin, Zhou, Xia, Baylin, Ana, Boer, Jolanda M.A., Brouwer, Ingeborg A., Campos, Hannia, Chaves, Paulo H. M., Chien, Kuo-Liong, de Faire, Ulf, Djoussé, Luc, Eiriksdottir, Gudny, El-Abbadi, Naglaa, Forouhi, Nita G., Gaziano, J. Michael, Geleijnse, Johanna M., Gigante, Bruna, Giles, Graham, Guallar, Eliseo, Gudnason, Vilmundur, Harris, Tamara, Harris, William S., Helmer, Catherine, Hellenius, Mai-Lis, Hodge, Allison, Hu, Frank B., Jacques, Paul F., Jansson, Jan-Håkan, Kalsbeek, Anya, Khaw, Kay-Tee, Koh, Woon-Puay, Laakso, Markku, Leander, Karin, Lin, Hung-Ju, Lind, Lars, Luben, Robert, Luo, Juhua, McKnight, Barbara, Mursu, Jaakko, Ninomiya, Toshiharu, Overvad, Kim, Psaty, Bruce M., Rimm, Eric, Schulze, Matthias B., Siscovick, David, Skjelbo Nielsen, Michael, Smith, Albert V., Steffen, Brian T., Steffen, Lyn, Sun, Qi, Sundström, Johan, Tsai, Michael Y., Tunstall-Pedoe, Hugh, Uusitupa, Matti I. J., van Dam, Rob M., Veenstra, Jenna, Verschuren, W.M. Monique, Wareham, Nick, Willett, Walter, Woodward, Mark, Yuan, Jian-Min, Micha, Renata, Lemaitre, Rozenn N, Mozaffarian, Dariush, and Risérus, Ulf

Published
2019
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107. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease : pooled analysis of 19 cohorts

Author

Ong, Kwok Leung, Marklund, Matti, Huang, Liping, Rye, Kerry-Anne, Hui, Nicholas, Pan, Xiong-Fei, Rebholz, Casey M., Kim, Hyunju, Steffen, Lyn M., Westing, Anniek C. van, Geleijnse, Johanna M., Hoogeveen, Ellen K., Chen, Yun-Yu, Chien, Kuo-Liong, Fretts, Amanda M., Lemaitre, Rozenn N., Imamura, Fumiaki, Forouhi, Nita G., Wareham, Nicholas J., Birukov, Anna, Jaeger, Susanne, Kuxhaus, Olga, Schulze, Matthias B., Mello, Vanessa Derenji de, Tuomilehto, Jaakko, Uusitupa, Matti, Lindstroem, Jaana, Tintle, Nathan, Harris, William S., Yamasaki, Keisuke, Hirakawa, Yoichiro, Ninomiya, Toshiharu, Tanaka, Toshiko, Ferrucci, Luigi, Bandinelli, Stefania, KVirtanen, Jyrki, Voutilainen, Ari, Jayasena, Tharusha, Thalamuthu, Anbupalam, Poljak, Anne, Bustamante, Sonia, Sachdev, Perminder S., Senn II, Mackenzie K, Rich, Stephen S., Tsai, Michael Y., Wood, Alexis C., Laakso, Markku, Lankinen, Maria, Yang, Xiaowei, Sun, Liang, Li, Huaixing, Lin, Xu, Nowak, Christoph, Ärnlöv, Johan, Risérus, Ulf, Lind, Lars, Le Goff, Melanie, Samieri, Cecilia, Helmer, Catherine, Qian, Frank, Micha, Renata, Tin, Adrienne, Koettgen, Anna, Boer, Ian H. de, Siscovick, David S., Mozaffarian, Dariush, Wu, Jason H. Y., Ong, Kwok Leung, Marklund, Matti, Huang, Liping, Rye, Kerry-Anne, Hui, Nicholas, Pan, Xiong-Fei, Rebholz, Casey M., Kim, Hyunju, Steffen, Lyn M., Westing, Anniek C. van, Geleijnse, Johanna M., Hoogeveen, Ellen K., Chen, Yun-Yu, Chien, Kuo-Liong, Fretts, Amanda M., Lemaitre, Rozenn N., Imamura, Fumiaki, Forouhi, Nita G., Wareham, Nicholas J., Birukov, Anna, Jaeger, Susanne, Kuxhaus, Olga, Schulze, Matthias B., Mello, Vanessa Derenji de, Tuomilehto, Jaakko, Uusitupa, Matti, Lindstroem, Jaana, Tintle, Nathan, Harris, William S., Yamasaki, Keisuke, Hirakawa, Yoichiro, Ninomiya, Toshiharu, Tanaka, Toshiko, Ferrucci, Luigi, Bandinelli, Stefania, KVirtanen, Jyrki, Voutilainen, Ari, Jayasena, Tharusha, Thalamuthu, Anbupalam, Poljak, Anne, Bustamante, Sonia, Sachdev, Perminder S., Senn II, Mackenzie K, Rich, Stephen S., Tsai, Michael Y., Wood, Alexis C., Laakso, Markku, Lankinen, Maria, Yang, Xiaowei, Sun, Liang, Li, Huaixing, Lin, Xu, Nowak, Christoph, Ärnlöv, Johan, Risérus, Ulf, Lind, Lars, Le Goff, Melanie, Samieri, Cecilia, Helmer, Catherine, Qian, Frank, Micha, Renata, Tin, Adrienne, Koettgen, Anna, Boer, Ian H. de, Siscovick, David S., Mozaffarian, Dariush, and Wu, Jason H. Y.

Abstract

OBJECTIVE: To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived a linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD). DESIGN: Pooled analysis. DATA SOURCES: A consortium of 19 studies from 12 countries identified up to May 2020. STUDY SELECTION: Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate. DATA EXTRACTION AND SYNTHESIS: Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using inverse variance weighted meta-analysis. MAIN OUTCOME MEASURES: Primary outcome of incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/ min/1.73 m(2). In a sensitivity analysis, incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m(2) and <75% of baseline rate. RESULTS: 25 570 participants were included in the primary outcome analysis and 4944 (19.3%) developed incident CKD during follow-up (weighted median 11.3 years). In multivariable adjusted models, higher levels of total seafood n-3 PUFAs were associated with a lower incident CKD risk (relative risk per interquintile range 0.92, 95% confidence interval 0.86 to 0.98; P=0.009, I-2=9.9%). In categorical analyses, participants with total seafood n-3 PUFA level in the highest fifth had 13% lower risk of incident CKD compared with those in the lowest fifth (0.87, 0.80 to 0.96; P=0.005, I-2=0.0%). Plant derived a linolenic acid levels were not associated with incident CKD (1.00, 0.94 to 1.06; P=0.94, I-2=5.8%). Similar results were obtained in the sensitivity analysis. The association appeared consistent across subgroups by age (=60 v <60 years), estimated glomerular filtration rate (60

Published
2023
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108. Ancestral diversity in lipoprotein(a) studies helps address evidence gaps

Author

Lee, Moa P., Dimos, Sofia F., Raffield, Laura M., Wang, Zhe, Ballou, Anna F., Downie, Carolina G., Arehart, Christopher H., Correa, Adolfo, De Vries, Paul S., Du, Zhaohui, Gignoux, Christopher R., Gordon-Larsen, Penny, Guo, Xiuqing, Haessler, Jeffrey, Howard, Annie Green, Hu, Yao, Kassahun, Helina, Kent, Shia T., Lopez, J. Antonio G., Monda, Keri L., North, Kari E., Peters, Ulrike, Preuss, Michael H., Rich, Stephen S., Rhodes, Shannon L., Yao, Jie, Yarosh, Rina, Tsai, Michael Y., Rotter, Jerome I., Kooperberg, Charles L., Loos, Ruth J.F., Ballantyne, Christie, Avery, Christy L., Graff, Mariaelisa, Lee, Moa P., Dimos, Sofia F., Raffield, Laura M., Wang, Zhe, Ballou, Anna F., Downie, Carolina G., Arehart, Christopher H., Correa, Adolfo, De Vries, Paul S., Du, Zhaohui, Gignoux, Christopher R., Gordon-Larsen, Penny, Guo, Xiuqing, Haessler, Jeffrey, Howard, Annie Green, Hu, Yao, Kassahun, Helina, Kent, Shia T., Lopez, J. Antonio G., Monda, Keri L., North, Kari E., Peters, Ulrike, Preuss, Michael H., Rich, Stephen S., Rhodes, Shannon L., Yao, Jie, Yarosh, Rina, Tsai, Michael Y., Rotter, Jerome I., Kooperberg, Charles L., Loos, Ruth J.F., Ballantyne, Christie, Avery, Christy L., and Graff, Mariaelisa

Abstract

Introduction The independent and causal cardiovascular disease risk factor lipoprotein(a) (Lp(a)) is elevated in >1.5 billion individuals worldwide, but studies have prioritised European populations. Methods Here, we examined how ancestrally diverse studies could clarify Lp(a)’s genetic architecture, inform efforts examining application of Lp(a) polygenic risk scores (PRS), enable causal inference and identify unexpected Lp(a) phenotypic effects using data from African (n=25 208), East Asian (n=2895), European (n=362 558), South Asian (n=8192) and Hispanic/Latino (n=8946) populations. Results Fourteen genome-wide significant loci with numerous population specific signals of large effect were identified that enabled construction of Lp(a) PRS of moderate (R2=15% in East Asians) to high (R2=50% in Europeans) accuracy. For all populations, PRS showed promise as a ‘rule out’ for elevated Lp(a) because certainty of assignment to the low-risk threshold was high (88.0%– 99.9%) across PRS thresholds (80th–99th percentile). Causal effects of increased Lp(a) with increased glycated haemoglobin were estimated for Europeans (p value =1.4×10−6), although inverse effects in Africans and East Asians suggested the potential for heterogeneous causal effects. Finally, Hispanic/Latinos were the only population in which known associations with coronary atherosclerosis and ischaemic heart disease were identified in external testing of Lp(a) PRS phenotypic effects. Conclusions Our results emphasise the merits of prioritising ancestral diversity when addressing Lp(a) evidence gaps., Introduction The independent and causal cardiovascular disease risk factor lipoprotein(a) (Lp(a)) is elevated in >1.5 billion individuals worldwide, but studies have prioritised European populations. Methods Here, we examined how ancestrally diverse studies could clarify Lp(a)'s genetic architecture, inform efforts examining application of Lp(a) polygenic risk scores (PRS), enable causal inference and identify unexpected Lp(a) phenotypic effects using data from African (n=25 208), East Asian (n=2895), European (n=362 558), South Asian (n=8192) and Hispanic/Latino (n=8946) populations. Results Fourteen genome-wide significant loci with numerous population specific signals of large effect were identified that enabled construction of Lp(a) PRS of moderate (R 2 =15% in East Asians) to high (R 2 =50% in Europeans) accuracy. For all populations, PRS showed promise as a 'rule out' for elevated Lp(a) because certainty of assignment to the low-risk threshold was high (88.0%-99.9%) across PRS thresholds (80th-99th percentile). Causal effects of increased Lp(a) with increased glycated haemoglobin were estimated for Europeans (p value =1.4×10 -6), although inverse effects in Africans and East Asians suggested the potential for heterogeneous causal effects. Finally, Hispanic/Latinos were the only population in which known associations with coronary atherosclerosis and ischaemic heart disease were identified in external testing of Lp(a) PRS phenotypic effects. Conclusions Our results emphasise the merits of prioritising ancestral diversity when addressing Lp(a) evidence gaps.

Published
2023

109. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

Author

de las Fuentes, Lisa, Schwander, Karen L., Brown, Michael R., Bentley, Amy R., Winkler, Thomas W., Sung, Yun Ju, Munroe, Patricia B., Miller, Clint L., Aschard, Hugo, Aslibekyan, Stella, Bartz, Traci M., Bielak, Lawrence F., Chai, Jin Fang, Cheng, Ching Yu, Dorajoo, Rajkumar, Feitosa, Mary F., Guo, Xiuqing, Hartwig, Fernando P., Horimoto, Andrea, Kolčić, Ivana, Lim, Elise, Liu, Yongmei, Manning, Alisa K., Marten, Jonathan, Musani, Solomon K., Noordam, Raymond, Padmanabhan, Sandosh, Rankinen, Tuomo, Richard, Melissa A., Ridker, Paul M., Smith, Albert V., Vojinovic, Dina, Zonderman, Alan B., Alver, Maris, Boissel, Mathilde, Christensen, Kaare, Freedman, Barry I., Gao, Chuan, Giulianini, Franco, Harris, Sarah E., He, Meian, Hsu, Fang Chi, Kühnel, Brigitte, Laguzzi, Federica, Li, Xiaoyin, Lyytikäinen, Leo Pekka, Nolte, Ilja M., Poveda, Alaitz, Rauramaa, Rainer, Riaz, Muhammad, Robino, Antonietta, Sofer, Tamar, Takeuchi, Fumihiko, Tayo, Bamidele O., van der Most, Peter J., Verweij, Niek, Ware, Erin B., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Zhan, Yiqiang, Amin, Najaf, Arking, Dan E., Ballantyne, Christie, Boerwinkle, Eric, Brody, Jennifer A., Broeckel, Ulrich, Campbell, Archie, Canouil, Mickaël, Chai, Xiaoran, Chen, Yii Der Ida, Chen, Xu, Chitrala, Kumaraswamy Naidu, Concas, Maria Pina, de Faire, Ulf, de Mutsert, Renée, de Silva, H. Janaka, de Vries, Paul S., Do, Ahn, Faul, Jessica D., Fisher, Virginia, Floyd, James S., Forrester, Terrence, Friedlander, Yechiel, Girotto, Giorgia, Gu, C. Charles, Hallmans, Göran, Heikkinen, Sami, Heng, Chew Kiat, Homuth, Georg, Hunt, Steven, Ikram, M. Arfan, Jacobs, David R., Kavousi, Maryam, Khor, Chiea Chuen, Kilpeläinen, Tuomas O., Koh, Woon Puay, Komulainen, Pirjo, Langefeld, Carl D., Liang, Jingjing, Liu, Kiang, Liu, Jianjun, Lohman, Kurt, Mägi, Reedik, Manichaikul, Ani W., McKenzie, Colin A., Meitinger, Thomas, Milaneschi, Yuri, Nauck, Matthias, Nelson, Christopher P., O’Connell, Jeffrey R., Palmer, Nicholette D., Pereira, Alexandre C., Perls, Thomas, Peters, Annette, Polašek, Ozren, Raitakari, Olli T., Rice, Kenneth, Rice, Treva K., Rich, Stephen S., Sabanayagam, Charumathi, Schreiner, Pamela J., Shu, Xiao Ou, Sidney, Stephen, Sims, Mario, Smith, Jennifer A., Starr, John M., Strauch, Konstantin, Tai, E. Shyong, Taylor, Kent D., Tsai, Michael Y., Uitterlinden, André G., van Heemst, Diana, Waldenberger, Melanie, Wang, Ya Xing, Wei, Wen Bin, Wilson, Gregory, Xuan, Deng, Yao, Jie, Yu, Caizheng, Yuan, Jian Min, Zhao, Wei, Becker, Diane M., Bonnefond, Amélie, Bowden, Donald W., Cooper, Richard S., Deary, Ian J., Divers, Jasmin, Esko, Tõnu, Franks, Paul W., Froguel, Philippe, Gieger, Christian, Jonas, Jost B., Kato, Norihiro, Lakka, Timo A., Leander, Karin, Lehtimäki, Terho, Magnusson, Patrik K.E., North, Kari E., Ntalla, Ioanna, Penninx, Brenda, Samani, Nilesh J., Snieder, Harold, Spedicati, Beatrice, van der Harst, Pim, Völzke, Henry, Wagenknecht, Lynne E., Weir, David R., Wojczynski, Mary K., Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Bouchard, Claude, Chasman, Daniel I., Evans, Michele K., Fox, Ervin R., Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L., Kardia, Sharon L.R., Krieger, Jose Eduardo, Mook-Kanamori, Dennis O., Peyser, Patricia A., Province, Michael M., Psaty, Bruce M., Rudan, Igor, Sim, Xueling, Smith, Blair H., van Dam, Rob M., van Duijn, Cornelia M., Wong, Tien Yin, Arnett, Donna K., Rao, Dabeeru C., Gauderman, James, Liu, Ching Ti, Morrison, Alanna C., Rotter, Jerome I., Fornage, Myriam, de las Fuentes, Lisa, Schwander, Karen L., Brown, Michael R., Bentley, Amy R., Winkler, Thomas W., Sung, Yun Ju, Munroe, Patricia B., Miller, Clint L., Aschard, Hugo, Aslibekyan, Stella, Bartz, Traci M., Bielak, Lawrence F., Chai, Jin Fang, Cheng, Ching Yu, Dorajoo, Rajkumar, Feitosa, Mary F., Guo, Xiuqing, Hartwig, Fernando P., Horimoto, Andrea, Kolčić, Ivana, Lim, Elise, Liu, Yongmei, Manning, Alisa K., Marten, Jonathan, Musani, Solomon K., Noordam, Raymond, Padmanabhan, Sandosh, Rankinen, Tuomo, Richard, Melissa A., Ridker, Paul M., Smith, Albert V., Vojinovic, Dina, Zonderman, Alan B., Alver, Maris, Boissel, Mathilde, Christensen, Kaare, Freedman, Barry I., Gao, Chuan, Giulianini, Franco, Harris, Sarah E., He, Meian, Hsu, Fang Chi, Kühnel, Brigitte, Laguzzi, Federica, Li, Xiaoyin, Lyytikäinen, Leo Pekka, Nolte, Ilja M., Poveda, Alaitz, Rauramaa, Rainer, Riaz, Muhammad, Robino, Antonietta, Sofer, Tamar, Takeuchi, Fumihiko, Tayo, Bamidele O., van der Most, Peter J., Verweij, Niek, Ware, Erin B., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Zhan, Yiqiang, Amin, Najaf, Arking, Dan E., Ballantyne, Christie, Boerwinkle, Eric, Brody, Jennifer A., Broeckel, Ulrich, Campbell, Archie, Canouil, Mickaël, Chai, Xiaoran, Chen, Yii Der Ida, Chen, Xu, Chitrala, Kumaraswamy Naidu, Concas, Maria Pina, de Faire, Ulf, de Mutsert, Renée, de Silva, H. Janaka, de Vries, Paul S., Do, Ahn, Faul, Jessica D., Fisher, Virginia, Floyd, James S., Forrester, Terrence, Friedlander, Yechiel, Girotto, Giorgia, Gu, C. Charles, Hallmans, Göran, Heikkinen, Sami, Heng, Chew Kiat, Homuth, Georg, Hunt, Steven, Ikram, M. Arfan, Jacobs, David R., Kavousi, Maryam, Khor, Chiea Chuen, Kilpeläinen, Tuomas O., Koh, Woon Puay, Komulainen, Pirjo, Langefeld, Carl D., Liang, Jingjing, Liu, Kiang, Liu, Jianjun, Lohman, Kurt, Mägi, Reedik, Manichaikul, Ani W., McKenzie, Colin A., Meitinger, Thomas, Milaneschi, Yuri, Nauck, Matthias, Nelson, Christopher P., O’Connell, Jeffrey R., Palmer, Nicholette D., Pereira, Alexandre C., Perls, Thomas, Peters, Annette, Polašek, Ozren, Raitakari, Olli T., Rice, Kenneth, Rice, Treva K., Rich, Stephen S., Sabanayagam, Charumathi, Schreiner, Pamela J., Shu, Xiao Ou, Sidney, Stephen, Sims, Mario, Smith, Jennifer A., Starr, John M., Strauch, Konstantin, Tai, E. Shyong, Taylor, Kent D., Tsai, Michael Y., Uitterlinden, André G., van Heemst, Diana, Waldenberger, Melanie, Wang, Ya Xing, Wei, Wen Bin, Wilson, Gregory, Xuan, Deng, Yao, Jie, Yu, Caizheng, Yuan, Jian Min, Zhao, Wei, Becker, Diane M., Bonnefond, Amélie, Bowden, Donald W., Cooper, Richard S., Deary, Ian J., Divers, Jasmin, Esko, Tõnu, Franks, Paul W., Froguel, Philippe, Gieger, Christian, Jonas, Jost B., Kato, Norihiro, Lakka, Timo A., Leander, Karin, Lehtimäki, Terho, Magnusson, Patrik K.E., North, Kari E., Ntalla, Ioanna, Penninx, Brenda, Samani, Nilesh J., Snieder, Harold, Spedicati, Beatrice, van der Harst, Pim, Völzke, Henry, Wagenknecht, Lynne E., Weir, David R., Wojczynski, Mary K., Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Bouchard, Claude, Chasman, Daniel I., Evans, Michele K., Fox, Ervin R., Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L., Kardia, Sharon L.R., Krieger, Jose Eduardo, Mook-Kanamori, Dennis O., Peyser, Patricia A., Province, Michael M., Psaty, Bruce M., Rudan, Igor, Sim, Xueling, Smith, Blair H., van Dam, Rob M., van Duijn, Cornelia M., Wong, Tien Yin, Arnett, Donna K., Rao, Dabeeru C., Gauderman, James, Liu, Ching Ti, Morrison, Alanna C., Rotter, Jerome I., and Fornage, Myriam

Abstract

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods:A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue.Discussion: Genome-wide interaction analysis of educational a

Published
2023

110. Assessment of postprandial triglycerides in clinical practice: Validation in a general population and coronary heart disease patients

Author

Perez-Martinez, Pablo, Alcala-Diaz, Juan F., Kabagambe, Edmon K., Garcia-Rios, Antonio, Tsai, Michael Y., Delgado-Lista, Javier, Kolovou, Genovefa, Straka, Robert J., Gomez-Delgado, Francisco, Hopkins, Paul N., Marin, Carmen, Borecki, Ingrid, Yubero-Serrano, Elena M., Hixson, James E., Camargo, Antonio, Province, Michael A., Lopez-Moreno, Javier, Rodriguez-Cantalejo, Fernando, Tinahones, Francisco J., Mikhailidis, Dimitri P., Perez-Jimenez, Francisco, Arnett, Donna K., Ordovas, Jose M., and Lopez-Miranda, Jose

Published
2016
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112. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

Author

Ma, Yiyi, Follis, Jack L, Smith, Caren E, Tanaka, Toshiko, Manichaikul, Ani W, Chu, Audrey Y, Samieri, Cecilia, Zhou, Xia, Guan, Weihua, Wang, Lu, Biggs, Mary L, Chen, Yii-Der I, Hernandez, Dena G, Borecki, Ingrid, Chasman, Daniel I, Rich, Stephen S, Ferrucci, Luigi, Irvin, Marguerite Ryan, Aslibekyan, Stella, Zhi, Degui, Tiwari, Hemant K, Claas, Steven A, Sha, Jin, Kabagambe, Edmond K, Lai, Chao-Qiang, Parnell, Laurence D, Lee, Yu-Chi, Amouyel, Philippe, Lambert, Jean-Charles, Psaty, Bruce M, King, Irena B, Mozaffarian, Dariush, McKnight, Barbara, Bandinelli, Stefania, Tsai, Michael Y, Ridker, Paul M, Ding, Jingzhong, Mstat, Kurt Lohmant, Liu, Yongmei, Sotoodehnia, Nona, Barberger-Gateau, Pascale, Steffen, Lyn M, Siscovick, David S, Absher, Devin, Arnett, Donna K, Ordovás, José M, and Lemaitre, Rozenn N

Published
2016
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115. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Author

Kilpeläinen, Tuomas O., Bentley, Amy R., Noordam, Raymond, Sung, Yun Ju, Schwander, Karen, Winkler, Thomas W., Jakupović, Hermina, Chasman, Daniel I., Manning, Alisa, Ntalla, Ioanna, Aschard, Hugues, Brown, Michael R., de las Fuentes, Lisa, Franceschini, Nora, Guo, Xiuqing, Vojinovic, Dina, Aslibekyan, Stella, Feitosa, Mary F., Kho, Minjung, Musani, Solomon K., Richard, Melissa, Wang, Heming, Wang, Zhe, Bartz, Traci M., Bielak, Lawrence F., Campbell, Archie, Dorajoo, Rajkumar, Fisher, Virginia, Hartwig, Fernando P., Horimoto, Andrea R. V. R., Li, Changwei, Lohman, Kurt K., Marten, Jonathan, Sim, Xueling, Smith, Albert V., Tajuddin, Salman M., Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Graff, Mariaelisa, Harris, Sarah E., He, Meian, Hsu, Fang-Chi, Jackson, Anne U., Zhao, Jing Hua, Kraja, Aldi T., Kühnel, Brigitte, Laguzzi, Federica, Lyytikäinen, Leo-Pekka, Nolte, Ilja M., Rauramaa, Rainer, Riaz, Muhammad, Robino, Antonietta, Rueedi, Rico, Stringham, Heather M., Takeuchi, Fumihiko, van der Most, Peter J., Varga, Tibor V., Verweij, Niek, Ware, Erin B., Wen, Wanqing, Li, Xiaoyin, Yanek, Lisa R., Amin, Najaf, Arnett, Donna K., Boerwinkle, Eric, Brumat, Marco, Cade, Brian, Canouil, Mickaël, Chen, Yii-Der Ida, Concas, Maria Pina, Connell, John, de Mutsert, Renée, de Silva, H. Janaka, de Vries, Paul S., Demirkan, Ayşe, Ding, Jingzhong, Eaton, Charles B., Faul, Jessica D., Friedlander, Yechiel, Gabriel, Kelley P., Ghanbari, Mohsen, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven C., Ikram, M. Arfan, Jonas, Jost B., Koh, Woon-Puay, Komulainen, Pirjo, Krieger, Jose E., Kritchevsky, Stephen B., Kutalik, Zoltán, Kuusisto, Johanna, Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Leander, Karin, Lemaitre, Rozenn N., Lewis, Cora E., Liang, Jingjing, Lifelines Cohort Study, Liu, Jianjun, Mägi, Reedik, Manichaikul, Ani, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Mohlke, Karen L., Mosley, Jr., Thomas H., Murray, Alison D., Nalls, Mike A., Nang, Ei-Ei Khaing, Nelson, Christopher P., Nona, Sotoodehnia, Norris, Jill M., Nwuba, Chiamaka Vivian, O’Connell, Jeff, Palmer, Nicholette D., Papanicolau, George J., Pazoki, Raha, Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Porteous, David J., Poveda, Alaitz, Raitakari, Olli T., Rich, Stephen S., Risch, Neil, Robinson, Jennifer G., Rose, Lynda M., Rudan, Igor, Schreiner, Pamela J., Scott, Robert A., Sidney, Stephen S., Sims, Mario, Smith, Jennifer A., Snieder, Harold, Sofer, Tamar, Starr, John M., Sternfeld, Barbara, Strauch, Konstantin, Tang, Hua, Taylor, Kent D., Tsai, Michael Y., Tuomilehto, Jaakko, Uitterlinden, André G., van der Ende, M. Yldau, van Heemst, Diana, Voortman, Trudy, Waldenberger, Melanie, Wennberg, Patrik, Wilson, Gregory, Xiang, Yong-Bing, Yao, Jie, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., de Faire, Ulf, Deary, Ian J., Elliott, Paul, Esko, Tõnu, Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Kato, Norihiro, Laakso, Markku, Lakka, Timo A., Lehtimäki, Terho, Magnusson, Patrik K. E., Oldehinkel, Albertine J., Penninx, Brenda W. J. H., Samani, Nilesh J., Shu, Xiao-Ou, van der Harst, Pim, Van Vliet-Ostaptchouk, Jana V., Vollenweider, Peter, Wagenknecht, Lynne E., Wang, Ya X., Wareham, Nicholas J., Weir, David R., Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Evans, Michele K., Franks, Paul W., Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L., Kelly, Tanika N., Liu, Yongmei, North, Kari E., Pereira, Alexandre C., Ridker, Paul M., Tai, E. Shyong, van Dam, Rob M., Fox, Ervin R., Kardia, Sharon L. R., Liu, Ching-Ti, Mook-Kanamori, Dennis O., Province, Michael A., Redline, Susan, van Duijn, Cornelia M., Rotter, Jerome I., Kooperberg, Charles B., Gauderman, W. James, Psaty, Bruce M., Rice, Kenneth, Munroe, Patricia B., Fornage, Myriam, Cupples, L. Adrienne, Rotimi, Charles N., Morrison, Alanna C., Rao, Dabeeru C., and Loos, Ruth J. F.

Published
2019
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116. Abstract MP62: Fatty Acid Biomarkers of 15:0, 17:0 and Trans 16:1n-7 and Incident Coronary Heart Disease and Stroke: A Pooling Project of 15 Prospective Cohorts in the Fatty Acids and Outcomes Research Consortium

Author

Ardisson Korat, Andres V, primary, Qian, Frank, additional, Malik, Vasanti, additional, Lehr, Marcus, additional, Imamura, Fumiaki, additional, Tintle, Nathan, additional, Laakso, Markku, additional, van Dam, Rob, additional, Harris, William, additional, Marklund, Matti, additional, Samieri, Cecilia, additional, Senn, MacKenzie, additional, Leander, Karin, additional, Forouhi, Nita, additional, Riserus, Ulf, additional, Chien, Kou-Liong, additional, Chen, Amelia, additional, Wood, Alexis, additional, Guan, Weihua, additional, Tsai, Michael Y, additional, Murphy, Rachel, additional, Siscovick, David S, additional, Lemaitre, Rozenn, additional, Mozaffarian, Dariush, additional, and Sun, Qi, additional

Published
2023
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117. Plasma Amino Acids in Early Pregnancy and Midpregnancy and Their Interplay With Phospholipid Fatty Acids in Association With the Risk of Gestational Diabetes Mellitus: Results From a Longitudinal Prospective Cohort

Author

Yang, Jiaxi, primary, Wu, Jing, additional, Tekola-Ayele, Fasil, additional, Li, Ling-Jun, additional, Bremer, Andrew A., additional, Lu, Ruijin, additional, Rahman, Mohammad L., additional, Weir, Natalie L., additional, Pang, Wei Wei, additional, Chen, Zhen, additional, Tsai, Michael Y., additional, and Zhang, Cuilin, additional

Published
2023
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118. Plasma amino acids in early and mid-pregnancy and their interplay with phospholipid fatty acids in association with the risk of gestational diabetes mellitus: results from a longitudinal prospective cohort

Author

Yang, Jiaxi, primary, Wu, Jing, primary, Tekola-Ayele, Fasil, primary, Li, Ling-Jun, primary, Bremer, Andrew A., primary, Lu, Ruijin, primary, Rahman, Mohammad L., primary, Weir, Natalie L., primary, Pang, Wei Wei, primary, Chen, Zhen, primary, Tsai, Michael Y., primary, and Zhang, Cuilin, primary

Published
2023
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119. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts

Author

Ong, Kwok Leung, primary, Marklund, Matti, additional, Huang, Liping, additional, Rye, Kerry-Anne, additional, Hui, Nicholas, additional, Pan, Xiong-Fei, additional, Rebholz, Casey M, additional, Kim, Hyunju, additional, Steffen, Lyn M, additional, van Westing, Anniek C, additional, Geleijnse, Johanna M, additional, Hoogeveen, Ellen K, additional, Chen, Yun-Yu, additional, Chien, Kuo-Liong, additional, Fretts, Amanda M, additional, Lemaitre, Rozenn N, additional, Imamura, Fumiaki, additional, Forouhi, Nita G, additional, Wareham, Nicholas J, additional, Birukov, Anna, additional, Jäger, Susanne, additional, Kuxhaus, Olga, additional, Schulze, Matthias B, additional, de Mello, Vanessa Derenji, additional, Tuomilehto, Jaakko, additional, Uusitupa, Matti, additional, Lindström, Jaana, additional, Tintle, Nathan, additional, Harris, William S, additional, Yamasaki, Keisuke, additional, Hirakawa, Yoichiro, additional, Ninomiya, Toshiharu, additional, Tanaka, Toshiko, additional, Ferrucci, Luigi, additional, Bandinelli, Stefania, additional, Virtanen, Jyrki K, additional, Voutilainen, Ari, additional, Jayasena, Tharusha, additional, Thalamuthu, Anbupalam, additional, Poljak, Anne, additional, Bustamante, Sonia, additional, Sachdev, Perminder S, additional, Senn, Mackenzie K, additional, Rich, Stephen S, additional, Tsai, Michael Y, additional, Wood, Alexis C, additional, Laakso, Markku, additional, Lankinen, Maria, additional, Yang, Xiaowei, additional, Sun, Liang, additional, Li, Huaixing, additional, Lin, Xu, additional, Nowak, Christoph, additional, Ärnlöv, Johan, additional, Risérus, Ulf, additional, Lind, Lars, additional, Le Goff, Mélanie, additional, Samieri, Cécilia, additional, Helmer, Catherine, additional, Qian, Frank, additional, Micha, Renata, additional, Tin, Adrienne, additional, Köttgen, Anna, additional, de Boer, Ian H, additional, Siscovick, David S, additional, Mozaffarian, Dariush, additional, and Wu, Jason HY, additional

Published
2023
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120. Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium

Author

Mozaffarian, Dariush, Kabagambe, Edmond K, Johnson, Catherine O, Lemaitre, Rozenn N, Manichaikul, Ani, Sun, Qi, Foy, Millennia, Wang, Lu, Wiener, Howard, Irvin, Marguerite R, Rich, Stephen S, Wu, Hongyu, Jensen, Majken K, Chasman, Daniel I, Chu, Audrey Y, Fornage, Myriam, Steffen, Lyn, King, Irena B, McKnight, Barbara, Psaty, Bruce M, Djoussé, Luc, Chen, Ida Y-D, Wu, Jason HY, Siscovick, David S, Ridker, Paul M, Tsai, Michael Y, Rimm, Eric B, Hu, Frank B, and Arnett, Donna K

Published
2015
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121. Association Between Omega-3 Fatty Acid Levels and Aortic Valve Calcium (from the Multi-Ethnic Study of Atherosclerosis)

Author

Pisaniello, Anthony D., primary, Alfaddagh, Abdulhamied, additional, Tibuakuu, Martin, additional, Whelton, Seamus P., additional, Czarny, Matthew J., additional, Blaha, Michael J., additional, Tsai, Michael Y., additional, Budoff, Matthew J., additional, Shea, Steven, additional, Allison, Matthew A., additional, and Post, Wendy S., additional

Published
2022
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123. Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

Author

Imamura, Fumiaki, Fretts, Amanda M., Marklund, Matti, Ardisson Korat, Andres V., Yang, Wei-Sin, Lankinen, Maria, Qureshi, Waqas, Helmer, Catherine, Chen, Tzu-An, Virtanen, Jyrki K., Wong, Kerry, Bassett, Julie K., Murphy, Rachel, Tintle, Nathan, Yu, Chaoyu Ian, Brouwer, Ingeborg A., Chien, Kuo-Liong, Chen, Yun-yu, Wood, Alexis C., del Gobbo, Liana C., Djousse, Luc, Geleijnse, Johanna M., Giles, Graham G., de Goede, Janette, Gudnason, Vilmundur, Harris, William S., Hodge, Allison, Hu, Frank, Koulman, Albert, Laakso, Markku, Lind, Lars, Lin, Hung-Ju, McKnight, Barbara, Rajaobelina, Kalina, Riserus, Ulf, Robinson, Jennifer G., Samieri, Cecilia, Senn, Mackenzie, Siscovick, David S., Soedamah-Muthu, Sabita S., Sotoodehnia, Nona, Sun, Qi, Tsai, Michael Y., Tuomainen, Tomi-Pekka, Uusitupa, Matti, Wagenknecht, Lynne E., Wareham, Nick J., Wu, Jason H. Y., Micha, Renata, Lemaitre, Rozenn N., Mozaffarian, Dariush, and Forouhi, Nita G.

Subjects
Fatty acids -- Analysis, Type 2 diabetes -- Analysis, Exercise -- Analysis, Triglycerides -- Analysis, Biological sciences
Abstract

Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D). Methods and findings Seventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970-1973 to 2006-2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3-75.5 years; % women = 20.4%-62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41-1.66; p < 0.001) for 16:0, 1.40 (1.33-1.48; p < 0.001) for 16:1n-7, 1.14 (1.05-1.22; p = 0.001) for 18:0, and 1.16 (1.07-1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I.sup.2 = 51.1%-73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94-1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors. Conclusions Concentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D., Author(s): Fumiaki Imamura 1,*, Amanda M. Fretts 2, Matti Marklund 3,4,5, Andres V. Ardisson Korat 6,7, Wei-Sin Yang 8, Maria Lankinen 9, Waqas Qureshi 10, Catherine Helmer 11, Tzu-An Chen [...]

Published
2020
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124. Lipoprotein(a) and Aortic Valve Calcification

Author

Bhatia, Harpreet S., primary, Zheng, Kang He, additional, Garg, Parveen K., additional, Guan, Weihua, additional, Whelton, Seamus P., additional, Budoff, Matthew J., additional, and Tsai, Michael Y., additional

Published
2022
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126. Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies–Singletons Cohort

Author

Tsoi, Kit Ying, primary, Zhu, Yeyi, additional, Wu, Jing, additional, Sun, Qi, additional, Hinkle, Stefanie N., additional, Li, Ling-Jun, additional, Chen, Zhen, additional, Weir, Natalie L., additional, Tsai, Michael Y., additional, Ma, Ronald C.W., additional, and Zhang, Cuilin, additional

Published
2022
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137. Omega-3 fatty acids, subclinical atherosclerosis, and cardiovascular events: Implications for primary prevention

Author

Alfaddagh, Abdulhamied, primary, Kapoor, Karan, additional, Dardari, Zeina A., additional, Bhatt, Deepak L., additional, Budoff, Matthew J., additional, Nasir, Khurram, additional, Miller, Michael, additional, Welty, Francine K., additional, Miedema, Michael D., additional, Shapiro, Michael D., additional, Tsai, Michael Y., additional, Blumenthal, Roger S., additional, and Blaha, Michael J., additional

Published
2022
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143. ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies

Author

Del Gobbo, Liana C., Imamura, Fumiaki, Aslibekyan, Stella, Marklund, Matti, Virtanen, Jyrki K., Wennberg, Maria, Yakoob, Mohammad Y., Chiuve, Stephanie E., dela Cruz, Luicito, Frazier-Wood, Alexis C., Fretts, Amanda M., Guallar, Eliseo, Matsumoto, Chisa, Prem, Kiesha, Tanaka, Tosh, Wu, Jason H. Y., Zhou, Xia, Helmer, Catherine, Ingelsson, Erik, Yuan, Jian-Min, Barberger-Gateau, Pascale, Campos, Hannia, Chaves, Paulo H. M., Djoussé, Luc, Giles, Graham G., Gómez-Aracena, Jose, Hodge, Allison M., Hu, Frank B., Jansson, Jan-Håkan, Johansson, Ingegerd, Khaw, Kay-Tee, Koh, Woon-Puay, Lemaitre, Rozenn N., Lind, Lars, Luben, Robert N., Rimm, Eric B., Risérus, Ulf, Samieri, Cecilia, Franks, Paul W., Siscovick, David S., Stampfer, Meir, Steffen, Lyn M., Steffen, Brian T., Tsai, Michael Y., van Dam, Rob M., Voutilainen, Sari, Willett, Walter C., Woodward, Mark, and Mozaffarian, Dariush

Published
2016
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144. Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes : Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

Author

Lai, Heidi T. M., Imamura, Fumiaki, Korat, Andres V. Ardisson, Murphy, Rachel A., Tintle, Nathan, Bassett, Julie K., Chen, Jiaying, Kröger, Janine, Chien, Kuo-Liong, Senn, Mackenzie, Wood, Alexis C., Forouhi, Nita G., Schulze, Matthias B., Harris, William S., Vasan, Ramachandran S., Hu, Frank, Giles, Graham G., Hodge, Allison, Djousse, Luc, Brouwer, Ingeborg A., Qian, Frank, Sun, Qi, Wu, Jason H. Y., Marklund, Matti, Lemaitre, Rozenn N., Siscovick, David S., Fretts, Amanda M., Shadyab, Aladdin H., Manson, JoAnn E., Howard, Barbara, V, Robinson, Jennifer G., Wallace, Robert B., Wareham, Nick J., Chen, Yii-Der Ida, Rotter, Jerome, I, Tsai, Michael Y., Micha, Renata, Mozaffarian, Dariush, Lai, Heidi T. M., Imamura, Fumiaki, Korat, Andres V. Ardisson, Murphy, Rachel A., Tintle, Nathan, Bassett, Julie K., Chen, Jiaying, Kröger, Janine, Chien, Kuo-Liong, Senn, Mackenzie, Wood, Alexis C., Forouhi, Nita G., Schulze, Matthias B., Harris, William S., Vasan, Ramachandran S., Hu, Frank, Giles, Graham G., Hodge, Allison, Djousse, Luc, Brouwer, Ingeborg A., Qian, Frank, Sun, Qi, Wu, Jason H. Y., Marklund, Matti, Lemaitre, Rozenn N., Siscovick, David S., Fretts, Amanda M., Shadyab, Aladdin H., Manson, JoAnn E., Howard, Barbara, V, Robinson, Jennifer G., Wallace, Robert B., Wareham, Nick J., Chen, Yii-Der Ida, Rotter, Jerome, I, Tsai, Michael Y., Micha, Renata, and Mozaffarian, Dariush

Abstract

OBJECTIVE: Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged >= 18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics. RESULTS: During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P >= 0.1). CONCLUSIONS: Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.

Published
2022
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145. Omega-3 and omega-6 polyunsaturated fatty acid biomarkers and sleep : a pooled analysis of cohort studies On behalf of the Fatty Acids and Outcomes Research Consortium (FORCE).

Author

Murphy, Rachel A, Tintle, Nathan, Harris, William S, Darvishian, Maryam, Marklund, Matti, Virtanen, Jyrki K, Hantunen, Sari, de Mello, Vanessa D, Tuomilehto, Jaakko, Lindström, Jaana, Bolt, Matthew A, Brouwer, Ingeborg A, Wood, Alexis C, Senn, Mackenzie, Redline, Susan, Tsai, Michael Y, Gudnason, Vilmundur, Eiriksdottir, Gudny, Lindberg, Eva, Shadyab, Aladdin H, Liu, Buyun, Carnethon, Mercedes, Uusitupa, Matti, Djousse, Luc, Risérus, Ulf, Lind, Lars, van Dam, Rob M, Koh, Woon-Puay, Shi, Peilin, Siscovick, David, Lemaitre, Rozenn N, Mozaffarian, Dariush, Murphy, Rachel A, Tintle, Nathan, Harris, William S, Darvishian, Maryam, Marklund, Matti, Virtanen, Jyrki K, Hantunen, Sari, de Mello, Vanessa D, Tuomilehto, Jaakko, Lindström, Jaana, Bolt, Matthew A, Brouwer, Ingeborg A, Wood, Alexis C, Senn, Mackenzie, Redline, Susan, Tsai, Michael Y, Gudnason, Vilmundur, Eiriksdottir, Gudny, Lindberg, Eva, Shadyab, Aladdin H, Liu, Buyun, Carnethon, Mercedes, Uusitupa, Matti, Djousse, Luc, Risérus, Ulf, Lind, Lars, van Dam, Rob M, Koh, Woon-Puay, Shi, Peilin, Siscovick, David, Lemaitre, Rozenn N, and Mozaffarian, Dariush

Abstract

BACKGROUND: n-3 and n-6 polyunsaturated fatty acids (PUFAs) have physiologic roles in sleep processes, but little is known regarding circulating n-3 and n-6 PUFA and sleep parameters. OBJECTIVES: To assess associations between biomarkers of n-3 and n-6 PUFA intake with self-reported sleep duration and difficulty falling sleeping in the Fatty Acids and Outcome Research Consortium. METHODS: Harmonized, de novo, individual-level analyses were performed and pooled across 12 cohorts. Participants were between 35 to 96 years old and from 5 nations. Circulating measures included alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), EPA + DPA + DHA, linoleic acid and arachidonic acid. Sleep duration (10 cohorts, N = 18,791) was categorized as short (≤6 hours), 7-8 hours (reference) or long (9 + hours). Difficulty falling sleeping (8 cohorts, N = 12,500) was categorized as yes or no. Associations between PUFAs, sleep duration, and difficulty falling sleeping were assessed by cross-sectional multinomial logistic regression using standardized protocols and covariates. Cohort-specific multivariable-adjusted odds ratios (ORs) per quintile of PUFAs were pooled with inverse-variance weighted meta-analysis. RESULTS: In pooled analysis adjusted for sociodemographics and health status, participants with higher very long-chain n-3 PUFAs were less likely to have long sleep duration. Comparing top vs. bottom quintiles, the multivariable-adjusted OR (95% confidence interval, CI) for long-sleep was 0.78 (0.65, 0.95) for DHA and for EPA + DPA + DHA, 0.76 (0.63, 0.93). Significant associations were not identified for ALA and n-6 PUFA with short sleep duration, or difficulty falling sleeping. CONCLUSIONS: Participants with higher levels of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the tem

Published
2022
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146. Plasma phospholipid n-3 and n-6 polyunsaturated fatty acids in relation to cardiometabolic markers and gestational diabetes: A longitudinal study within the prospective NICHD Fetal Growth Studies

Author

Zhu, Yeyi, Li, Mengying, Rahman, Mohammad L., Hinkle, Stefanie N., Wu, Jing, Weir, Natalie L., Lin, Yuan, Yang, Huixia, Tsai, Michael Y., Ferrara, Assiamira, and Zhang, Cuilin

Subjects
Unsaturated fatty acids -- Research, Gestational diabetes -- Risk factors, Phospholipids -- Research, Pregnant women -- Health aspects, Diabetes mellitus, Nutritional requirements, Linolenic acids, Health, Type 2 diabetes, Homeostasis, Insulin, Linoleic acid, Fetal development, Omega 3 fatty acids, Glucose, Pregnancy, Fatty acids, Omega 6 fatty acids, Child health, Children, Biological sciences
Abstract

Background Despite dietary recommendations of polyunsaturated fatty acids (PUFAs) for cardiometabolic health, n-3 and n-6 PUFAs and their interplay in relation to diabetes risk remain debated. Importantly, data among pregnant women are scarce. We investigated individual plasma phospholipid n-3 and n-6 PUFAs in early to midpregnancy in relation to subsequent risk of gestational diabetes mellitus (GDM). Methods and findings Within the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singleton Cohort (n = 2,802), individual plasma phospholipid n-3 and n-6 PUFAs levels were measured at gestational weeks (GWs) 10-14, 15-26, 23-31, and 33-39 among 107 GDM cases (ascertained on average at GW 27) and 214 non-GDM controls. Conditional logistic regression was used, adjusting for major risk factors for GDM. After adjusting for covariates, individual n-3 eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) were inversely correlated with insulin-resistance markers, whereas individual n-6 dihomo-gamma-linolenic acid (DGLA) was positively correlated with insulin-resistance markers. At GW 15-26, a standard deviation (SD) increase in total n-3 PUFAs and individual n-3 DPA was associated with a 36% (adjusted odds ratio 0.64; 95% CI 0.42-0.96; P = 0.042) and 33% (0.67; 95% CI 0.45-0.99; P = 0.047) lower risk of GDM, respectively; however, the significance did not persist after post hoc false-discovery rate (FDR) correction (FDR-corrected P values > 0.05). Associations between total n-6 PUFAs and GDM were null, whereas associations with individual n-6 PUFAs were differential. Per SD increase, gamma-linolenic acid (GLA) at GWs 10-14 and DGLA at GWs 10-14 and 15-26 were significantly associated with a 1.40- to 1.95-fold higher risk of GDM, whereas docosatetraenoic acid (DTA) at GW 15-26 was associated with a 45% (0.55; 95% CI 0.37-0.83) lower risk of GDM (all FDR-corrected P values < 0.05). Null associations were observed for linoleic acid (LA) in either gestational window in relation to risk of GDM. Women with high ([greater than or equal to]median) n-3 PUFAs and low ( Conclusions Our findings may suggest a potential role of primarily endogenously metabolized plasma phospholipid n-6 PUFAs including GLA, DGLA, and DTA in early to midpregnancy in the development of GDM. Null findings on primarily diet-derived n-3 EPA and DHA and n-6 LA do not provide strong evidence to suggest a beneficial role in prevention of GDM, although not excluding the potential benefit of EPA and DHA on glucose-insulin homeostasis given the inverse associations with insulin-resistance markers. Our findings highlight the importance of assessing individual circulating PUFAs to investigate their distinct pathophysiologic roles in glucose homeostasis in pregnancy., Author(s): Yeyi Zhu 1,2,*, Mengying Li 3, Mohammad L. Rahman 4, Stefanie N. Hinkle 3, Jing Wu 5, Natalie L. Weir 6, Yuan Lin 7, Huixia Yang 8, Michael Y. [...]

Published
2019
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150. Independent Association of Lipoprotein(a) and Coronary Artery Calcification With Atherosclerotic Cardiovascular Risk

Author

Mehta, Anurag, primary, Vasquez, Nestor, additional, Ayers, Colby R., additional, Patel, Jaideep, additional, Hooda, Ananya, additional, Khera, Amit, additional, Blumenthal, Roger S., additional, Shapiro, Michael D., additional, Rodriguez, Carlos J., additional, Tsai, Michael Y., additional, Sperling, Laurence S., additional, Virani, Salim S., additional, Blaha, Michael J., additional, and Joshi, Parag H., additional

Published
2022
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