Search

Your search keyword '"Treibel, Thomas"' showing total 802 results
Start Over Author "Treibel, Thomas"
802 results on '"Treibel, Thomas"'

101. Large Clones of Pre-Existing T Cells Drive Early Immunity Against SARS-COV-2 and LCMV Infection

Author

Milighetti, Martina, primary, Peng, Yanchun, additional, Tan, Cedric, additional, Mark, Michal, additional, Nageswaran, Gayathri, additional, Byrne, Suzanne, additional, Ronel, Tahel, additional, Peacock, Tom, additional, Mayer, Andreas, additional, Chandran, Aneesh, additional, Rosenheim, Joshua, additional, Whelan, Matthew V.X., additional, Yao, Xuan, additional, Liu, Guihai, additional, Felce, Suet Ling, additional, Dong, Tao, additional, Mentzer, Alexander J., additional, Knight, Julian, additional, Balloux, François, additional, Greenstein, Erez, additional, Reich-Zeliger, Shlomit, additional, Pade, Corinna, additional, Gibbons, Joseph, additional, Semper, Amanda, additional, Brooks, Tim, additional, Otter, Ashley, additional, Altmann, Daniel M., additional, Boyton, Rosemary J., additional, Maini, Mala K., additional, McKnight, Aine, additional, Manisty, Charlotte, additional, Treibel, Thomas A., additional, Moon, James C., additional, Investigators, COVIDsortium, additional, Noursadeghi, Mahdad, additional, and Chain, Benny, additional

Published
2023
Full Text
View/download PDF

102. 6 CMR service improvement via deployed service-level rapid CMR protocols with integrated AI

Author

Artico, Jessica, primary, Laymouna, Reem, additional, Fox, Paige, additional, Shiwani, Hunain, additional, Kurdi, Hibba, additional, Abioudin, Aderonke, additional, Pierce, Iain, additional, Davies, Rhodri, additional, Xue, Hui, additional, Kellman, Peter, additional, Westwood, Mark, additional, Manisty, Charlotte, additional, Treibel, Thomas, additional, and Moon, James, additional

Published
2023
Full Text
View/download PDF

107. Persistent symptoms after COVID-19 during the first wave are not associated with differential immunity to SARS-CoV-2

Author

Altmann, Daniel, primary, Reynolds, Catherine, additional, Joy, George, additional, Otter, Ashley, additional, Gibbons, Joseph, additional, Pade, Corinna, additional, Swadling, Leo, additional, Maini, Mala, additional, Brooks, Tim, additional, Semper, Amanda, additional, McKnight, Aine, additional, Noursadeghi, Mahdad, additional, Manisty, Charlotte, additional, Treibel, Thomas, additional, Moon, James, additional, and Boyton, Rosemary, additional

Published
2022
Full Text
View/download PDF

108. Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection

Author

Captur, Gabriella, primary, Moon, James C., additional, Topriceanu, Constantin-Cristian, additional, Joy, George, additional, Swadling, Leo, additional, Hallqvist, Jenny, additional, Doykov, Ivan, additional, Patel, Nina, additional, Spiewak, Justyna, additional, Baldwin, Tomas, additional, Hamblin, Matt, additional, Menacho, Katia, additional, Fontana, Marianna, additional, Treibel, Thomas A., additional, Manisty, Charlotte, additional, O'Brien, Ben, additional, Gibbons, Joseph M., additional, Pade, Corrina, additional, Brooks, Tim, additional, Altmann, Daniel M., additional, Boyton, Rosemary J., additional, McKnight, Áine, additional, Maini, Mala K., additional, Noursadeghi, Mahdad, additional, Mills, Kevin, additional, and Heywood, Wendy E., additional

Published
2022
Full Text
View/download PDF

109. Myocardial Scar and Mortality in Severe Aortic Stenosis: Data From the BSCMR Valve Consortium

Author

Musa, Tarique A., Treibel, Thomas A., Vassiliou, Vassiliou S., Captur, Gabriella, Singh, Anvesha, Chin, Calvin, Dobson, Laura E., Pica, Silvia, Loudon, Margaret, Malley, Tamir, Rigolli, Marzia, Foley, James R.J., Bijsterveld, Petra, Law, Graham R., Dweck, Marc R., Myerson, Saul G., McCann, Gerry P., Prasad, Sanjay K., Moon, James C., and Greenwood, John P.

Published
2018
Full Text
View/download PDF

118. Preprocedural Prognostic Factors in Acute Decompensated Aortic Stenosis

Author

Patel, Kush P, primary, Badiani, Sveeta, additional, Ganeshalingam, Ajithish, additional, Vijayakumar, Mohit, additional, Thornton, George, additional, Mathur, Anthony, additional, Kennon, Simon, additional, Bhattacharyya, Sanjeev, additional, Baumbach, Andreas, additional, Moon, James C, additional, Treibel, Thomas A, additional, Mullen, Michael J, additional, and Lloyd, Guy, additional

Published
2022
Full Text
View/download PDF

119. Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

Author

Reynolds, Catherine J., Pade, Corinna, Gibbons, Joseph M., Otter, Ashley D., Lin, Kai-Min, Muñoz Sandoval, Diana, Pieper, Franziska P., Butler, David K., Liu, Siyi, Joy, George, Forooghi, Nasim, Treibel, Thomas A., Manisty, Charlotte, Moon, James C., Semper, Amanda, Brooks, Tim, McKnight, Áine, Altmann, Daniel M., Boyton, Rosemary J., Abbass, Hakam, Abiodun, Aderonke, Alfarih, Mashael, Alldis, Zoe, Amin, Oliver E., Andiapen, Mervyn, Artico, Jessica, Augusto, João B., Baca, Georgina L., Bailey, Sasha N. L., Bhuva, Anish N., Boulter, Alex, Bowles, Ruth, Bracken, Olivia V., O’Brien, Ben, Bullock, Natalie, Captur, Gabriella, Carr, Olivia, Champion, Nicola, Chan, Carmen, Chandran, Aneesh, Coleman, Tom, Couto de Sousa, Jorge, Couto-Parada, Xose, Cross, Eleanor, Cutino-Moguel, Teresa, D’Arcangelo, Silvia, Davies, Rhodri H., Douglas, Brooke, Di Genova, Cecilia, Dieobi-Anene, Keenan, Diniz, Mariana O., Ellis, Anaya, Feehan, Karen, Finlay, Malcolm, Fontana, Marianna, Francis, Sasha, Gillespie, David, Gilroy, Derek, Hamblin, Matt, Harker, Gabrielle, Hemingway, Georgia, Hewson, Jacqueline, Heywood, Wendy, Hickling, Lauren M., Hicks, Bethany, Hingorani, Aroon D., Howes, Lee, Itua, Ivie, Jardim, Victor, Lee, Wing-Yiu Jason, Jensen, Melaniepetra, Jones, Jessica, Jones, Meleri, Kapil, Vikas, Kelly, Caoimhe, Kurdi, Hibba, Lambourne, Jonathan, Lloyd, Aaron, Louth, Sarah, Maini, Mala K., Mandadapu, Vineela, Menacho, Katia, Mfuko, Celina, Mills, Kevin, Millward, Sebastian, Mitchelmore, Oliver, Moon, Christopher, Moon, James, Murray, Sam M., Noursadeghi, Mahdad, Otter, Ashley, Palma, Susana, Parker, Ruth, Patel, Kush, Pawarova, Mihaela, Petersen, Steffen E., Piniera, Brian, Rannigan, Lisa, Rapala, Alicja, Richards, Amy, Robathan, Matthew, Rosenheim, Joshua, Rowe, Cathy, Royds, Matthew, Sackville West, Jane, Sambile, Genine, Schmidt, Nathalie M., Selman, Hannah, Seraphim, Andreas, Simion, Mihaela, Smit, Angelique, Sugimoto, Michelle, Swadling, Leo, Taylor, Stephen, Temperton, Nigel, Thomas, Stephen, Thornton, George D., Tucker, Art, Varghese, Ann, Veerapen, Jessry, Vijayakumar, Mohit, Warner, Tim, Welch, Sophie, White, Hannah, Wodehouse, Theresa, Wynne, Lucinda, Zahedi, Dan, Chain, Benjamin, and Medical Research Council (MRC)

Subjects
QR355, B-Lymphocytes, Science & Technology, Multidisciplinary, SARS-CoV-2, General Science & Technology, T-Lymphocytes, Immunization, Secondary, COVID-19, Cross Reactions, Antibodies, Viral, T-CELL IMMUNITY, Antibodies, Neutralizing, Multidisciplinary Sciences, Mice, INFECTION, Spike Glycoprotein, Coronavirus, Science & Technology - Other Topics, Animals, Humans, COVIDsortium Investigators§, COVIDsortium Immune Correlates Network§, BNT162 Vaccine
Abstract

INTRODUCTION B.1.1.529 (Omicron) and its subvariants pose new challenges for control of the COVID-19 pandemic. Although vaccinated populations are relatively protected from severe disease and death, countries with high vaccine uptake are experiencing substantial caseloads with breakthrough infection and frequent reinfection. RATIONALE We analyzed cross-protective immunity against B.1.1.529 (Omicron) in triple-vaccinated health care workers (HCWs) with different immune-imprinted histories of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the ancestral Wuhan Hu-1, B.1.1.7 (Alpha), and B.1.617.2 (Delta) waves and after infection during the B.1.1.529 (Omicron) wave in previously infection-naïve individuals and those with hybrid immunity, to investigate whether B.1.1.529 (Omicron) infection could further boost adaptive immunity. Spike subunit 1 (S1) receptor binding domain (RBD) and whole spike binding, live virus neutralizing antibody (nAb) potency, memory B cell (MBC) frequency, and T cell responses against peptide pools and naturally processed antigen were assessed. RESULTS B and T cell recognition and nAb potency were boosted against previous variants of concern (VOCs) in triple-vaccinated HCWs, but this enhanced immunity was attenuated against B.1.1.529 (Omicron) itself. Furthermore, immune imprinting after B.1.1.7 (Alpha) infection resulted in reduced durability of antibody binding against B.1.1.529 (Omicron), and S1 RBD and whole spike VOC binding correlated poorly with live virus nAb potency. Half of triple-vaccinated HCWs showed no T cell response to B.1.1.529 (Omicron) S1 processed antigen, and all showed reduced responses to the B.1.1.529 (Omicron) peptide pool, irrespective of SARS-CoV-2 infection history. Mapping T cell immunity in class II human leukocyte antigen transgenics showed that individual spike mutations could result in loss or gain of T cell epitope recognition, with changes to T cell effector and regulatory programs. Triple-vaccinated, previously infection-naïve individuals infected during the B.1.1.529 (Omicron) wave showed boosted cross-reactive S1 RBD and whole spike binding, live virus nAb potency, and T cell immunity against previous VOCs but less so against B.1.1.529 (Omicron) itself. Immune imprinting from prior Wuhan Hu-1 infection abrogated any enhanced cross-reactive antibody binding, T cell recognition, MBC frequency, or nAb potency after B.1.1.529 (Omicron) infection. CONCLUSION Vaccine boosting results in distinct, imprinted patterns of hybrid immunity with different combinations of SARS-CoV-2 infection and vaccination. Immune protection is boosted by B.1.1.529 (Omicron) infection in the triple-vaccinated, previously infection-naïve individuals, but this boosting is lost with prior Wuhan Hu-1 imprinting. This “hybrid immune damping” indicates substantial subversion of immune recognition and differential modulation through immune imprinting and may be the reason why the B.1.1.529 (Omicron) wave has been characterized by breakthrough infection and frequent reinfection with relatively preserved protection against severe disease in triple-vaccinated individuals.

Published
2022

120. United Kingdom standards for non-invasive cardiac imaging: recommendations from the Imaging Council of the British Cardiovascular Society

Author

Treibel, Thomas A., Kelion, Andrew, Ingram, Thomas E., Archbold, R. Andrew, Myerson, Saul G., Menezes, Leon J., Morgan-Hughes, Gareth J., Schofield, Rebecca, Keenan, Niall G., Clarke, Sarah C., Keys, Alan, Keogh, Bruce, Masani, Navroz, Ray, Simon, Westwood, Mark, Pearce, Keith, Colebourn, Claire L., Bull, Russell K., Greenwood, John Pierre, Roditi, Giles H., Lloyd, Guy, Imaging Council of the British Cardiovascular Society, British Society of Echocardiography, British Cardiovascular Society, British Society of Cardiovascular Magnetic Resonance, British Nuclear Cardiology Society, and British Society of Cardiovascular Imaging/Computed Tomography

Abstract

Heart and circulatory diseases affect more than seven million people in the UK. Non-invasive cardiac imaging is a critical element of contemporary cardiology practice. Progressive improvements in technology over the last 20 years have increased diagnostic accuracy in all modalities and led to the incorporation of non-invasive imaging into many standard cardiac clinical care pathways. Cardiac imaging tests are requested by a variety of healthcare practitioners and performed in a range of settings from the most advanced hospitals to local health centres. Imaging is used to detect the presence and consequences of cardiovascular disease, as well as to monitor the response to therapies. The previous UK national imaging strategy statement which brought together all of the non-invasive imaging modalities was published in 2010. The purpose of this document is to collate contemporary standards developed by the modality-specific professional organisations which make up the British Cardiovascular Society Imaging Council, bringing together common and essential recommendations. The development process has been inclusive and iterative. Imaging societies (representing both cardiology and radiology) reviewed and agreed on the initial structure. The final document therefore represents a position, which has been generated inclusively, presents rigorous standards, is applicable to clinical practice and deliverable. This document will be of value to a variety of healthcare professionals including imaging departments, the National Health Service or other organisations, regulatory bodies, commissioners and other purchasers of services, and service users, i.e., patients, and their relatives.

Published
2022

121. HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19

Author

Astbury, Stuart, Reynolds, Catherine J, Butler, David K, Munoz-Sandoval, Diana C, Lin, Kai-Min, Pieper, Franziska P, Otter, Ashley, Kouraki, Afroditi, Cusin, Lola, Nightingale, Jessica, Vijay, Amrita, Craxford, Simon, Aithal, Guruprasad P, Tighe, Patrick J, Gibbons, Joseph M, Pade, Corinna, Joy, George, Maini, Mala, Chain, Benny, Semper, Amanda, Brooks, Timothy, Ollivere, Benjamin J, Noursadeghi, Mahdad, Treibel, Thomas A, Manisty, Charlotte, Moon, James C, Valdes, Ana M, Boyton, Rosemary J, and Altmann, Daniel M

Subjects
immunogenetics, HLA, T cell immunity, SARS-CoV-2, vaccine, COVID-19
Abstract

SARS-CoV-2 infection results in different outcomes ranging from asymptomatic infection to mild or severe disease and death. Reasons for this diversity of outcome include differences in challenge dose, age, gender, comorbidity and host genomic variation. Human leukocyte antigen (HLA) polymorphisms may influence immune response and disease outcome. We investigated the association of HLAII alleles with case definition symptomatic COVID-19, virus-specific antibody and T-cell immunity. A total of 1364 UK healthcare workers (HCWs) were recruited during the first UK SARS-CoV-2 wave and analysed longitudinally, encompassing regular PCR screening for infection, symptom reporting, imputation of HLAII genotype and analysis for antibody and T-cell responses to nucleoprotein (N) and spike (S). Of 272 (20%) HCW who seroconverted, the presence of HLA-DRB1*13:02 was associated with a 6·7-fold increased risk of case definition symptomatic COVID-19. In terms of immune responsiveness, HLA-DRB1*15:02 was associated with lower nucleocapsid T-cell responses. There was no association between DRB1 alleles and anti-spike antibody titres after two COVID vaccine doses. However, HLA DRB1*15:01 was associated with increased spike T-cell responses following both first and second dose vaccination. Trial registration: NCT04318314 and ISRCTN15677965.

Published
2022

122. Model-free phasor image analysis of quantitative myocardial T1 mapping

Author

Franssen, Wouter M.J. (author), Treibel, Thomas A. (author), Seraphim, Andreas (author), Weingärtner, S.D. (author), Terenzi, Camilla (author), Franssen, Wouter M.J. (author), Treibel, Thomas A. (author), Seraphim, Andreas (author), Weingärtner, S.D. (author), and Terenzi, Camilla (author)

Abstract

Model-free phasor image analysis, well established in fluorescence lifetime imaging and only recently applied to qMRI T2 data processing, is here adapted and validated for myocardial qMRI T1 mapping. Contrarily to routine mono-exponential fitting procedures, phasor enables mapping the lifetime information from all image voxels to a single plot, without resorting to any regression fitting analysis, and describing multi-exponential qMRI decays without biases due to violated modelling assumptions. In this feasibility study, we test the performance of our recently developed full-harmonics phasor method for unravelling partial-volume effects, motion or pathological tissue alteration, respectively on a numerically-simulated dataset, a healthy subject scan, and two pilot patient datasets. Our results show that phasor analysis can be used, as alternative method to fitting analysis or other model-free approaches, to identify motion artifacts or partial-volume effects at the myocardium-blood interface as characteristic deviations, or delineations of scar and remote myocardial tissue in patient data., ImPhys/Computational Imaging, ImPhys/Medical Imaging

Published
2022
Full Text
View/download PDF

123. Cardiac phase-resolved late gadolinium enhancement imaging

Author

Weingärtner, S.D. (author), Demirel, Omer Burak (author), Gama, Francisco. (author), Pierce, Iain (author), Treibel, Thomas A. (author), Schulz-Menger, Jeanette (author), Akcakaya, Mehmet (author), Weingärtner, S.D. (author), Demirel, Omer Burak (author), Gama, Francisco. (author), Pierce, Iain (author), Treibel, Thomas A. (author), Schulz-Menger, Jeanette (author), and Akcakaya, Mehmet (author)

Abstract

Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) imaging is the clinical reference for assessment of myocardial scar and focal fibrosis. However, current LGE techniques are confined to imaging of a single cardiac phase, which hampers assessment of scar motility and does not allow cross-comparison between multiple phases. In this work, we investigate a three step approach to obtain cardiac phase-resolved LGE images: (1) Acquisition of cardiac phase-resolved imaging data with varying T1 weighting. (2) Generation of semi-quantitative T*1 maps for each cardiac phase. (3) Synthetization of LGE contrast to obtain functional LGE images. The proposed method is evaluated in phantom imaging, six healthy subjects at 3T and 20 patients at 1.5T. Phantom imaging at 3T demonstrates consistent contrast throughout the cardiac cycle with a coefficient of variation of 2.55 ± 0.42%. In-vivo results show reliable LGE contrast with thorough suppression of the myocardial tissue is healthy subjects. The contrast between blood and myocardium showed moderate variation throughout the cardiac cycle in healthy subjects (coefficient of variation 18.2 ± 3.51%). Images were acquired at 40–60 ms and 80 ms temporal resolution, at 3T and 1.5, respectively. Functional LGE images acquired in patients with myocardial scar visualized scar tissue throughout the cardiac cycle, albeit at noticeably lower imaging resolution and noise resilience than the reference technique. The proposed technique bears the promise of integrating the advantages of phase-resolved CMR with LGE imaging, but further improvements in the acquisition quality are warranted for clinical use., ImPhys/Computational Imaging, ImPhys/Medical Imaging

Published
2022
Full Text
View/download PDF

124. Myocardial Approximate Spin-lock Dispersion Mapping using a Simultaneous T2 and TRAFF2 Mapping at 3T MRI

Author

Tourais, Joao (author), Demirel, Omer Burak (author), Tao, Q. (author), Pierce, Iain (author), Thornton, George D. (author), Treibel, Thomas A. (author), Akcakaya, Mehmet (author), Weingärtner, S.D. (author), Tourais, Joao (author), Demirel, Omer Burak (author), Tao, Q. (author), Pierce, Iain (author), Thornton, George D. (author), Treibel, Thomas A. (author), Akcakaya, Mehmet (author), and Weingärtner, S.D. (author)

Abstract

Ischemic heart disease (IHD) is one of the leading causes of death worldwide. Myocardial infarction (MI) represents a third of all IHD cases, and cardiac magnetic resonance imaging (MRI) is often used to assess its damage to myocardial viability. Late gadolinium enhancement (LGE) is the current gold standard, but the use of gadolinium-based agents limits the clinical applicability in some patients. Spin-lock (SL) dispersion has recently been proposed as a promising non-contrast biomarker for the assessment of MI. However, at 3T, the required range of SL preparations acquired at different amplitudes suffers from specific absorption rate (SAR) limitations and off-resonance artifacts. Relaxation Along a Fictitious Field (RAFF) is an alternative to SL preparations with lower SAR requirements, while still sampling relaxation in the rotating frame. In this study, a single breath-hold simultaneous TRAFF2 and T2 mapping sequence is proposed for SL dispersion mapping at 3T. Excellent reproducibility (coefficient of variations lower than 10%) was achieved in phantom experiments, indicating good intrascan repeatability. The average myocardial TRAFF2, T2, and SL dispersion obtained with the proposed sequence (68.0±10.7 ms, 44.0±4.0 ms, and 0.4±0.2 ×10-4 s2, respectively) were comparable to the reference methods (62.7±11.7 ms, 41.2±2.4 ms, and 0.3±0.2x 10-4s2, respectively). High visual map quality, free of B0 and B1+ related artifacts, for T2, TRAFF2, and SL dispersion maps were obtained in phantoms and in vivo, suggesting promise in clinical use at 3T. Clinical relevance - and imaging promises non-contrast assessment of scar and focal fibrosis in a single breath-hold using approximate spin-lock dispersion mapping., ImPhys/Medical Imaging, ImPhys/Computational Imaging

Published
2022
Full Text
View/download PDF

125. Model-free phasor image analysis of quantitative myocardial T1 mapping

Author

Franssen, Wouter M.J., Treibel, Thomas A., Seraphim, Andreas, Weingärtner, Sebastian, Terenzi, Camilla, Franssen, Wouter M.J., Treibel, Thomas A., Seraphim, Andreas, Weingärtner, Sebastian, and Terenzi, Camilla

Abstract

Model-free phasor image analysis, well established in fluorescence lifetime imaging and only recently applied to qMRI T2 data processing, is here adapted and validated for myocardial qMRI T1 mapping. Contrarily to routine mono-exponential fitting procedures, phasor enables mapping the lifetime information from all image voxels to a single plot, without resorting to any regression fitting analysis, and describing multi-exponential qMRI decays without biases due to violated modelling assumptions. In this feasibility study, we test the performance of our recently developed full-harmonics phasor method for unravelling partial-volume effects, motion or pathological tissue alteration, respectively on a numerically-simulated dataset, a healthy subject scan, and two pilot patient datasets. Our results show that phasor analysis can be used, as alternative method to fitting analysis or other model-free approaches, to identify motion artifacts or partial-volume effects at the myocardium-blood interface as characteristic deviations, or delineations of scar and remote myocardial tissue in patient data.

Published
2022

128. Diagnostic performance of T1 and T2 mapping to detect intramyocardial hemorrhage in reperfused ST‐segment elevation myocardial infarction (STEMI) patients

Author

Bulluck, Heerajnarain, Rosmini, Stefania, Abdel‐Gadir, Amna, Bhuva, Anish N., Treibel, Thomas A., Fontana, Marianna, Gonzalez‐Lopez, Esther, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna S., Manisty, Charlotte, Yellon, Derek M., Moon, James C., and Hausenloy, Derek J.

Published
2017
Full Text
View/download PDF

131. 5 Improving the diagnostic accuracy of apical hypertrophic cardiomyopathy

Author

Hughes, Rebecca, primary, Shiwani, Hunain, additional, Rosmini, Stefania, additional, Augusto, Joao, additional, Burke, Liam, additional, Pierce, Iain, additional, Castelletti, Silvia, additional, Xue, Hui, additional, Kellman, Peter, additional, Lopes, Luis, additional, Treibel, Thomas, additional, Manisty, Charlotte, additional, Captur, Gabriella, additional, Davies, Rhodri, additional, and Moon, James, additional

Published
2022
Full Text
View/download PDF

132. Association of Myocardial Fibrosis and Stroke Volume by Cardiovascular Magnetic Resonance in Patients With Severe Aortic Stenosis With Outcome After Valve Replacement

Author

Thornton, George D., primary, Musa, Tarique A., additional, Rigolli, Marzia, additional, Loudon, Margaret, additional, Chin, Calvin, additional, Pica, Silvia, additional, Malley, Tamir, additional, Foley, James R. J., additional, Vassiliou, Vassilios S., additional, Davies, Rhodri H., additional, Captur, Gabriella, additional, Dobson, Laura E., additional, Moon, James C., additional, Dweck, Marc R., additional, Myerson, Saul G., additional, Prasad, Sanjay K., additional, Greenwood, John P., additional, McCann, Gerry P., additional, Singh, Anvesha, additional, and Treibel, Thomas A., additional

Published
2022
Full Text
View/download PDF

134. CALCIUM VOLUME QUANTIFICATION BY COMPUTED TOMOGRAPHY ANGIOGRAPHY TO DIAGNOSE SEVERE AORTIC STENOSIS

Author

Geers, Jolien, Craig, Neil, Joshi, Shruti, Lembo, Maria, Singh, Trisha, patel, kush, Treibel, Thomas, Song, Jae-Kwan, Clavel, Marie-Annick, Grodecki, Kajetan, Kwiecinski, Jacek, Pina, Pamela, Lorenzatti, Daniel, Latib, Azeem, Slipczuk, Leandro, Rodriguez-Palomares, Jose F., Lee, Seung-Pyo, Slomka, Piotr, Cosyns, Bernard, Newby, David E., Dey, Damini, and Dweck, Marc

Published
2024
Full Text
View/download PDF

137. Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

Author

Doykov, Ivan, primary, Spiewak, Justyna, additional, Gilmour, Kimberly C., additional, Gibbons, Joseph M, additional, Pade, Corinna, additional, McKnight, Áine, additional, Noursadeghi, Mahdad, additional, Maini, Mala K, additional, Manisty, Charlotte, additional, Treibel, Thomas, additional, Captur, Gabriella, additional, Fontana, Marianna, additional, Boyton, Rosemary J, additional, Altmann, Daniel M, additional, Brooks, Tim, additional, Semper, Amanda, additional, Moon, James C, additional, Mills, Kevin, additional, and Heywood, Wendy, additional

Published
2022
Full Text
View/download PDF

138. Automated In‐Line Artificial Intelligence Measured Global Longitudinal Shortening and Mitral Annular Plane Systolic Excursion: Reproducibility and Prognostic Significance

Author

Xue, Hui, primary, Artico, Jessica, additional, Davies, Rhodri H., additional, Adam, Robert, additional, Shetye, Abhishek, additional, Augusto, João B., additional, Bhuva, Anish, additional, Fröjdh, Fredrika, additional, Wong, Timothy C., additional, Fukui, Miho, additional, Cavalcante, João L., additional, Treibel, Thomas A., additional, Manisty, Charlotte, additional, Fontana, Marianna, additional, Ugander, Martin, additional, Moon, James C., additional, Schelbert, Erik B., additional, and Kellman, Peter, additional

Published
2022
Full Text
View/download PDF

139. Improving cardiovascular magnetic resonance access in low- and middle-income countries for cardiomyopathy assessment: rapid cardiovascular magnetic resonance

Author

Menacho, Katia Devorha, primary, Ramirez, Sara, additional, Perez, Aylen, additional, Dragonetti, Laura, additional, Perez de Arenaza, Diego, additional, Katekaru, Diana, additional, Illatopa, Violeta, additional, Munive, Sara, additional, Rodriguez, Bertha, additional, Shimabukuro, Ana, additional, Cupe, Kelly, additional, Bansal, Rajiv, additional, Bhargava, Vivek, additional, Rodriguez, Ivonne, additional, Seraphim, Andreas, additional, Knott, Kris, additional, Abdel-Gadir, Amna, additional, Guerrero, Salomon, additional, Lazo, Marco, additional, Uscamaita, David, additional, Rivero, Marco, additional, Amaya, Neil, additional, Sharma, Sanjiv, additional, Peix, Amelia, additional, Treibel, Thomas, additional, Manisty, Charlotte, additional, Mohiddin, Sam, additional, Litt, Harold, additional, Han, Yuchi, additional, Fernandes, Juliano, additional, Jacob, Ron, additional, Westwood, Mark, additional, Ntusi, Ntobeko, additional, Herrey, Anna, additional, Walker, John Malcolm, additional, and Moon, James, additional

Published
2022
Full Text
View/download PDF

142. Mitral regurgitation quantification by cardiac magnetic resonance imaging (MRI) remains reproducible between software solutions

Author

Grafton-Clarke, Ciaran, primary, Thornton, George, additional, Fidock, Benjamin, additional, Archer, Gareth, additional, Hose, Rod, additional, van der Geest, Rob J., additional, Zhong, Liang, additional, Swift, Andrew J., additional, Wild, James M., additional, De Gárate, Estefania, additional, Bucciarelli-Ducci, Chiara, additional, Plein, Sven, additional, Treibel, Thomas A., additional, Flather, Marcus, additional, Vassiliou, Vassilios S., additional, and Garg, Pankaj, additional

Published
2022
Full Text
View/download PDF

143. Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Author

Swadling, Leo, Diniz, Mariana O., Schmidt, Nathalie M., Amin, Oliver E., Chandran, Aneesh, Shaw, Emily, Pade, Corinna, Gibbons, Joseph M., Le Bert, Nina, Tan, Anthony T., Jeffery-Smith, Anna, Tan, Cedric C. S., Tham, Christine Y. L., Kucykowicz, Stephanie, Aidoo-Micah, Gloryanne, Rosenheim, Joshua, Davies, Jessica, Johnson, Marina, Jensen, Melanie P., Joy, George, McCoy, Laura E., Valdes, Ana M., Chain, Benjamin M., Goldblatt, David, Altmann, Daniel M., Boyton, Rosemary J., Manisty, Charlotte, Treibel, Thomas A., Moon, James C., Abbass, Hakam, Abiodun, Aderonke, Alfarih, Mashael, Alldis, Zoe, Andiapen, Mervyn, Artico, Jessica, Augusto, João B., Baca, Georgina L., Bailey, Sasha N. L., Bhuva, Anish N., Boulter, Alex, Bowles, Ruth, Bracken, Olivia V., O’Brien, Ben, Brooks, Tim, Bullock, Natalie, Butler, David K., Captur, Gabriella, Champion, Nicola, Chan, Carmen, Collier, David, de Sousa, Jorge Couto, Couto-Parada, Xose, Cutino-Moguel, Teresa, Davies, Rhodri H., Douglas, Brooke, Di Genova, Cecilia, Dieobi-Anene, Keenan, Ellis, Anaya, Feehan, Karen, Finlay, Malcolm, Fontana, Marianna, Forooghi, Nasim, Gaier, Celia, Gilroy, Derek, Hamblin, Matt, Harker, Gabrielle, Hewson, Jacqueline, Hickling, Lauren M., Hingorani, Aroon D., Howes, Lee, Hughes, Alun, Hughes, Gemma, Hughes, Rebecca, Itua, Ivie, Jardim, Victor, Lee, Wing-Yiu Jason, Jensen, Melanie petra, Jones, Jessica, Jones, Meleri, Kapil, Vikas, Kurdi, Hibba, Lambourne, Jonathan, Lin, Kai-Min, Louth, Sarah, Mandadapu, Vineela, McKnight, Áine, Menacho, Katia, Mfuko, Celina, Mitchelmore, Oliver, Moon, Christopher, Murray, Sam M., Noursadeghi, Mahdad, Otter, Ashley, Palma, Susana, Parker, Ruth, Patel, Kush, Pawarova, Babita, Petersen, Steffen E., Piniera, Brian, Pieper, Franziska P., Pope, Daniel, Prossora, Mary, Rannigan, Lisa, Rapala, Alicja, Reynolds, Catherine J., Richards, Amy, Robathan, Matthew, Sambile, Genine, Semper, Amanda, Seraphim, Andreas, Simion, Mihaela, Smit, Angelique, Sugimoto, Michelle, Taylor, Stephen, Temperton, Nigel J., Thomas, Stephen, Thornton, George D., Tucker, Art, Veerapen, Jessry, Vijayakumar, Mohit, Welch, Sophie, Wodehouse, Theresa, Wynne, Lucinda, Zahedi, Dan, Dorp, Lucy van, Balloux, Francois, McKnight, Áine, Bertoletti, Antonio, Maini, Mala K., Swadling, Leo [0000-0002-0537-6715], Schmidt, Nathalie M [0000-0002-9841-8418], Gibbons, Joseph M [0000-0002-7238-2381], Le Bert, Nina [0000-0003-0502-2527], Tham, Christine YL [0000-0002-2913-7591], Kucykowicz, Stephanie [0000-0002-8849-218X], Rosenheim, Joshua [0000-0003-0171-2053], McCoy, Laura E [0000-0001-9503-7946], Valdes, Ana M [0000-0003-1141-4471], Chain, Benjamin M [0000-0002-7417-3970], Goldblatt, David [0000-0002-0769-5242], Boyton, Rosemary J [0000-0002-5608-0797], van Dorp, Lucy [0000-0002-6211-2310], Balloux, Francois [0000-0003-1978-7715], Noursadeghi, Mahdad [0000-0002-4774-0853], Bertoletti, Antonio [0000-0002-2942-0485], Maini, Mala K [0000-0001-6384-1462], Apollo - University of Cambridge Repository, Medical Research Council (MRC), and Multiple Sclerosis Society

Subjects
Male, Transcription, Genetic, 631/250/1619/554, medicine.disease_cause, DISEASE, Neutralization, Cohort Studies, 13/1, 631/250/2152/1566/1571, INFECTION, Coronaviridae, Asymptomatic Infections, Polymerase, Coronavirus, Multidisciplinary, biology, article, virus diseases, DNA-Directed RNA Polymerases, Multidisciplinary Sciences, 13/31, Seroconversion, Cohort, Science & Technology - Other Topics, VIRUS, Female, 82/75, HEALTH-CARE WORKERS, Antibody, ANTIBODY-RESPONSES, General Science & Technology, Health Personnel, 13/106, IMMUNITY, Evolution, Molecular, Memory T Cells, In vivo, Multienzyme Complexes, medicine, Humans, EXPOSURE, 631/326/596/4130, COVIDsortium Investigators, Cell Proliferation, PATHOGENS, Science & Technology, SARS-CoV-2, MEMORY, CORONAVIRUSES, COVID-19, Membrane Proteins, 631/250/254, biology.organism_classification, Virology, biology.protein
Abstract

Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute to the rapid clearance of SARS-CoV-2 and other coronavirus infections1–3. Here we hypothesize that pre-existing memory T cell responses, with cross-protective potential against SARS-CoV-2 (refs. 4–11), would expand in vivo to support rapid viral control, aborting infection. We measured SARS-CoV-2-reactive T cells, including those against the early transcribed replication–transcription complex (RTC)12,13, in intensively monitored healthcare workers (HCWs) who tested repeatedly negative according to PCR, antibody binding and neutralization assays (seronegative HCWs (SN-HCWs)). SN-HCWs had stronger, more multispecific memory T cells compared with a cohort of unexposed individuals from before the pandemic (prepandemic cohort), and these cells were more frequently directed against the RTC than the structural-protein-dominated responses observed after detectable infection (matched concurrent cohort). SN-HCWs with the strongest RTC-specific T cells had an increase in IFI27, a robust early innate signature of SARS-CoV-2 (ref. 14), suggesting abortive infection. RNA polymerase within RTC was the largest region of high sequence conservation across human seasonal coronaviruses (HCoV) and SARS-CoV-2 clades. RNA polymerase was preferentially targeted (among the regions tested) by T cells from prepandemic cohorts and SN-HCWs. RTC-epitope-specific T cells that cross-recognized HCoV variants were identified in SN-HCWs. Enriched pre-existing RNA-polymerase-specific T cells expanded in vivo to preferentially accumulate in the memory response after putative abortive compared to overt SARS-CoV-2 infection. Our data highlight RTC-specific T cells as targets for vaccines against endemic and emerging Coronaviridae.

Published
2021

146. 1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping

Author

Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Fontana, Marianna, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, and Hausenloy, Derek J

Published
2016
Full Text
View/download PDF

150. Valvular heart disease: shifting the focus to the myocardium.

Author

Marsan, Nina Ajmone, Delgado, Victoria, Shah, Dipan J, Pellikka, Patricia, Bax, Jeroen J, Treibel, Thomas, and Cavalcante, João L

Subjects
HEART valve diseases, MAGNETIC resonance imaging, HEART dilatation, MYOCARDIUM, MITRAL valve insufficiency
Abstract

Adverse cardiac remodelling is the main determinant of patient prognosis in degenerative valvular heart disease (VHD). However, to give an indication for valvular intervention, current guidelines include parameters of cardiac chamber dilatation or function which are subject to variability, do not directly reflect myocardial structural changes, and, more importantly, seem to be not sensitive enough in depicting early signs of myocardial dysfunction before irreversible myocardial damage has occurred. To avoid irreversible myocardial dysfunction, novel biomarkers are advocated to help refining indications for intervention and risk stratification. Advanced echocardiographic modalities, including strain analysis, and magnetic resonance imaging have shown to be promising in providing new tools to depict the important switch from adaptive to maladaptive myocardial changes in response to severe VHD. This review, therefore, summarizes the current available evidence on the role of these new imaging biomarkers in degenerative VHD, aiming at shifting the clinical perspective from a valve-centred to a myocardium-focused approach for patient management and therapeutic decision-making. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results