477 results on '"Tomoaia-Cotisel A"'
Search Results
102. Silicon release from hydroxyapatites in water and simulated body fluid
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Oana Cadar, Petre T. Frangopol, Aurora Mocanu, Ossi Horovitz, Maria Tomoaia-Cotisel, Daniel Oltean, Gertrud Alexandra Paltinean, and Gheorghe Tomoaia
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Materials science ,Silicon ,chemistry ,Chemical engineering ,Simulated body fluid ,chemistry.chemical_element ,Hydroxyapatites ,General Chemistry - Published
- 2017
103. Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study
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Mocanu, Aurora, primary, Cadar, Oana, additional, Frangopol, Petre T., additional, Petean, Ioan, additional, Tomoaia, Gheorghe, additional, Paltinean, Gertrud-Alexandra, additional, Racz, Csaba Pal, additional, Horovitz, Ossi, additional, and Tomoaia-Cotisel, Maria, additional
- Published
- 2021
- Full Text
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104. Do common metrics add value? Perspectives from NIH Clinical and Translational Science Awards (CTSA) Consortium hubs
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Welch, Lisa C., primary, Tomoaia-Cotisel, Andrada, additional, Chang, Hong, additional, Mendel, Peter, additional, Etchegaray, Jason M., additional, Qureshi, Nabeel, additional, Fenwood-Hughes, Marguerite, additional, Parajulee, Anshu, additional, and Selker, Harry P., additional
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- 2020
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105. Understanding the maternal and child health system response to payment for performance in Tanzania using a causal loop diagram approach
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Neha S. Singh, Zaid Chalabi, Karl Blanchet, Andrada Tomoaia-Cotisel, Josephine Borghi, John Maiba, Agnes Rwashana Semwanga, Rachel Cassidy, and Peter Binyaruka
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Maternal and child health ,Health (social science) ,Process management ,Maternal-Child Health Services ,media_common.quotation_subject ,Causal loop diagram ,Population ,Staffing ,Qualitative property ,Tanzania ,Article ,Health systems ,History and Philosophy of Science ,Health facility ,Pregnancy ,Humans ,Evaluation ,Child ,education ,Reimbursement, Incentive ,media_common ,Motivation ,education.field_of_study ,Child Health ,Stakeholder ,Primary care ,Payment ,Incentive ,Female ,Business ,Payment for performance - Abstract
Payment for performance (P4P) has been employed in low and middle-income (LMIC) countries to improve quality and coverage of maternal and child health (MCH) services. However, there is a lack of consensus on how P4P affects health systems. There is a need to evaluate P4P effects on health systems using methods suitable for evaluating complex systems. We developed a causal loop diagram (CLD) to further understand the pathways to impact of P4P on delivery and uptake of MCH services in Tanzania. The CLD was developed and validated using qualitative data from a process evaluation of a P4P scheme in Tanzania, with additional stakeholder dialogue sought to strengthen confidence in the diagram. The CLD maps the interacting mechanisms involved in provider achievement of targets, reporting of health information, and population care seeking, and identifies those mechanisms affected by P4P. For example, the availability of drugs and medical commodities impacts not only provider achievement of P4P targets but also demand of services and is impacted by P4P through the availability of additional facility resources and the incentivisation of district managers to reduce drug stock outs. The CLD also identifies mechanisms key to facility achievement of targets but are not within the scope of the programme; the activities of health facility governing committees and community health workers, for example, are key to demand stimulation and effective resource use at the facility level but both groups were omitted from the incentive system. P4P design considerations generated from this work include appropriately incentivising the availability of drugs and staffing in facilities and those responsible for demand creation in communities. Further research using CLDs to study heath systems in LMIC is urgently needed to further our understanding of how systems respond to interventions and how to strengthen systems to deliver better coverage and quality of care., Highlights • Holistic analysis key to avoiding suboptimal P4P performance. • Availability of drugs is influenced by P4P and affects success of P4P. • Need to incentivise groups outside facility that support service coverage.
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- 2021
106. TESTING OF NEW EXPERIMENTAL GIOMERS: WATER SORPTION, CONVERSION DEGREE, RADIOPACITY, MICROSTRUCTURE AND BIOLOGICAL BEHAVIOR.
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CIMPEAN, SANDA-ILEANA, AMBROSIE, IOANA, MOLDOVAN, MADALINA, DELEAN, ADA, PRODAN, DOINA, PREJMEREAN, CRISTINA, MOLDOVAN, MARIOARA, TOMOAIA-COTISEL, MARIA, and COLCERIU-BURTEA, LOREDANA
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RADIOPACITY ,WATER immersion ,SORPTION ,INFRARED spectroscopy ,SCANNING electron microscopy - Abstract
Two experimental giomers (G1 and G2) were obtained and then evaluated for water sorption-by weighing the specimens before and after water immersion, for conversion degree (DC)- by Fourier Transform Infrared Spectrometry, for radiopacity-by using the intraoral sensor system Ez Sensor 1.5 Vatech E-Woo (Korea), in relation to their microstructural characteristics assessed by Scanning Electron Microscopy (SEM). They were compared to a commercial giomer: Beautifil II. Both experimental and commercial giomers were also tested by subcutaneous and intramuscular implantation tests, to establish and compare their biological behavior. Intensity of the inflammatory reaction, tissue repair status and the presence of the capsule were the main criteria assessed. After 7 days, the mean values of DC were: 65.8% (Beautifil II), 62.2% (G2) and 60.5 (G1). DC increased after the initial polymerization. Giomers showed mean values of water sorption, below 40 µg/mm3. A certain swelling of the polymer matrix without dislocations of particles could be seen on SEM images. The mean values of radiopacity were between 2.15-2.99 [mmAl]. Giomers were slight to moderate irritants for soft tissues, with no significant difference between the samples. Promising results make G1 and G2 possible alternative to Beautifil II, that can be further improved. [ABSTRACT FROM AUTHOR]
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- 2022
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107. IR, Raman and surface-enhanced Raman study of desferrioxamine B and its Fe(III) complex, ferrioxamine B
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Cozar, O., Leopold, N., Jelic, C., Chiş, V., David, L., Mocanu, A., and Tomoaia-Cotişel, M.
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- 2006
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108. Evaluation of initial progress to implement Common Metrics across the NIH Clinical and Translational Science Awards (CTSA) Consortium
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Welch, Lisa C., primary, Tomoaia-Cotisel, Andrada, additional, Noubary, Farzad, additional, Chang, Hong, additional, Mendel, Peter, additional, Parajulee, Anshu, additional, Fenwood-Hughes, Marguerite, additional, Etchegaray, Jason M., additional, Qureshi, Nabeel, additional, Chandler, Redonna, additional, and Selker, Harry P., additional
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- 2020
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109. Novel Porous Forsterite Ceramics Biocompatibility and Bioactivity Evaluation
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Gorea, Maria, primary, Naghiu, Marieta-Adriana, additional, Avram, Alexandra, additional, Petean, Ioan, additional, Mocanu, Aurora, additional, and Tomoaia-Cotisel, Maria, additional
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- 2020
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110. In-vitro Antibacterial Activity of Novel Nanostructured Composites Based on Forsterite and Silver Nanoparticles
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Avram, Alexandra, primary, Gorea, Maria, additional, Rapuntean, Sorin, additional, Mocanu, Aurora, additional, Paltinean, Gertrud Alexandra, additional, Varhelyi Jr., Csaba, additional, Petean, Ioan, additional, Horovitz, Ossi, additional, and Tomoaia-Cotisel, Maria, additional
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- 2020
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111. Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature
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Maria Tomoaia-Cotisel, Corina Garbo, Ossi Horovitz, Reka Balint, Aurora Mocanu, Lucia Timis, and Ioan Petean
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Crystallinity ,Materials science ,Chemical engineering ,General Chemistry - Published
- 2017
112. CURRENT STATUS AND TRENDS IN ORAL HEALTH CARE TECHNOLOGIES. A PERSPECTIVE REVIEW.
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FLOREA, Diana Alexandra, DOBROTA, Cristina Teodora, CARPA, Rahela, RIGA, Sorin, and TOMOAIA-COTISEL, Maria
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MEDICAL technology ,ORAL hygiene products ,ORAL health ,INTELLIGENT sensors ,PATIENT decision making - Abstract
This review proposes a comparative analysis of the benefits and harms of alternative technologies applied in oral health care. Many innovative technologies have been introduced in oral hygiene, oriented to personalize brushing routines and provide brushing feedback. Built-in smart sensors enhance the performance of toothbrushes in terms of brushing pressure, motion precision, and video recognition of negatively affected areas. Further, connected smartphone applications are available to guide users in proper brushing techniques, thus allowing greater control over their oral care practices. DNA sequencing technology is used to formulate oral care products targeted to specific mechanisms of action. Oral hygiene and products are nano-modified, and targeted to specific sites. The purpose of this perspective review is to provide an update of the technology available for improved oral health, patient selfcare and evidence to aid patients in making better decisions when a large number of products are available on the market. [ABSTRACT FROM AUTHOR]
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- 2022
113. In Vitro Sensitivity Research Concerning Some Microorganisms at Hydroxyquinoline and Cupric Derivatives Deposited onto Hydroxyapatite
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Nicodim Fit, Gheorghe Rapuntean, Horea Farcau, Flore Chirilă, Sorin Rapuntean, Maria Tomoaia-Cotisel, Corina Garbo, Vasile Miclaus, and Alexandru Raul Pop
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lcsh:Veterinary medicine ,biology ,Microorganism ,Pharmaceutical Science ,Micrococcus ,Prototheca ,medicine.disease_cause ,biology.organism_classification ,Yeast ,Microbiology ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,medicine ,copper, hydroxyapatite, hydroxyquinoline, microorganisms, sensitivity ,lcsh:SF600-1100 ,Pharmacology (medical) ,Escherichia coli ,Staphylococcus ,Nutrient agar ,Bacteria ,Nuclear chemistry - Abstract
Introduction : The preparations based on hydroxyquinoline, in various combinations, are used in medicine, being shown to have an inhibitory effect against bacteria, molds, fungi, parasites, and viruses, but also having other beneficial effects mentioned in other medical conditions (anti-cancer, anti-degenerative, anti-inflammatory). Aims : In vitro susceptibility testing of microorganisms: bacteria (Gram positive and Gram negative), yeast ( Candida spp.,) and unicellular algae ( Prototheca spp.) at the preparations based on hydroxyquinoline (HQ) and its cupric derivatives deposited on hydroxyapatite (HAP). Materials and methods : There were tested microbial strains of the following genera: Escherichia , Staphylococcus , Micrococcus , Bacillus , Candida , and Prototheca . The tested products (developed in the Laboratory for Nanobiomaterials Synthesis, Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, UBB Cluj-Napoca) were developed in three versions: 1) HQ–Cu 2+ –HAP 1 ; 2) HQ–Cu 2+ –HAP 2 ; and 3) NHQ–Cu 2+ –HAP 2 , where NHQ stands for nitro hydroxyquinoline. Determination of the inhibitory effect was conducted by diffusion technique in nutrient agar, according to CLSI 2013 standards, with necessary adaptations for testing of products made in the form of suspensions. Results : Following interpretation, it was found that the inhibition zones, arising from the antimicrobial effect of the tested products showed variability in size, depending on the test product and the microbial strain: Escherichia coli (8-10 mm), Staphylococcus sp. (17.6 - 23.2 mm), Micrococcus spp. (24.4 - 27.6 mm), Bacillus spp. (14.0 - 16.0 mm), Candida spp. (20.4 - 25.2 mm), Prototheca spp. (20.8 - 30.0 mm). From the three tested products, the best efficacy was found at the product no. 3 (NHQ – Cu 2+ – HAP 2 ), followed by no. 1 (HQ– Cu 2+ –HAP 1 ) and no. 2 (HQ–Cu 2+ –HAP 2 ). Conclusions : The inhibitory effect was bactericidal, manifested more intensively against Gram-positive bacteria, yeasts, and prototheca. Such products, prepared in the form of suspensions, may have practical application in the prevention and treatment of skin or hooves disorders. No resistance phenomena are recorded. Keywords : copper, hydroxyapatite, hydroxyquinoline, microorganisms, sensitivity.
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- 2016
114. Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration
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Corina, Garbo, Janis, Locs, Matteo, D'Este, Gerard, Demazeau, Aurora, Mocanu, Cecilia, Roman, Ossi, Horovitz, and Maria, Tomoaia-Cotisel
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Bone Regeneration ,synthesis ,hydroxyapatite ,Spectrum Analysis, Raman ,Nanostructures ,X-Ray Diffraction ,Biomimetic Materials ,Metals ,Spectroscopy, Fourier Transform Infrared ,bioceramics ,ions release ,multi-substituted hydroxyapatites ,characterization ,Hydroxyapatites ,Particle Size ,Porosity ,nanomaterials ,Original Research - Abstract
Purpose Compositional tailoring is gaining more attention in the development of advanced biomimetic nanomaterials. In this study, we aimed to prepare advanced multi-substituted hydroxyapatites (ms-HAPs), which show similarity with the inorganic phase of bones and might have therapeutic potential for bone regeneration. Materials Novel nano hydroxyapatites substituted simultaneously with divalent cations: Mg2+ (1.5%), Zn2+ (0.2%), Sr2+ (5% and 10%), and Si (0.2%) as orthosilicate (SiO44-) were designed and successfully synthesized for the first time. Methods The ms-HAPs were obtained via a wet-chemistry precipitation route without the use of surfactants, which is a safe and ecologically friendly method. The composition of synthesized materials was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The materials were characterized by X-ray powder diffraction (XRD), FT-IR and FT-Raman spectroscopy, BET measurements and by imaging techniques using high-resolution TEM (HR-TEM), FE-SEM coupled with EDX, and atomic force microscopy (AFM). The ion release was measured in water and in simulated body fluid (SBF). Results Characterization methods confirmed the presence of the unique phase of pure stoichiometric HAP structure and high compositional purity of all synthesized nanomaterials. The doping elements influenced the crystallite size, the crystallinity, lattice parameters, morphology, particle size and shape, specific surface area, and porosity. Results showed a decrease in both nanoparticle size and crystallinity degree, coupled with an increase in specific surface area of these advanced ms-HAP materials, in comparison with pure stoichiometric HAP. The release of biologically important ions was confirmed in different liquid media, both in static and simulated dynamic conditions. Conclusion The incorporation of the four substituting elements into the HAP structure is demonstrated. Synthesized nanostructured ms-HAP materials might inherit the in vivo effects of substituting functional elements and properties of hydroxyapatite for bone healing and regeneration. Results revealed a rational tailoring approach for the design of a next generation of bioactive ms-HAPs as promising candidates for bone regeneration.
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- 2019
115. BIOMIMETIC NANOCOMPOSITE STRUCTURES DESIGNED FOR COATING OF ORTHOPEDIC IMPLANTS: AFM INVESTIGATION.
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BALINT, REKA, PETEAN, IOAN, FRANGOPOL, PETRE T., MOCANU, AURORA, ARGHIR, GEORGE, RIGA, SORIN, TOMOAIA, GHEORGHE, HOROVITZ, OSSI, and TOMOAIA-COTISEL, MARIA
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ORTHOPEDIC implants ,SURFACE coatings ,BIOMIMETIC materials ,ATOMIC force microscopy ,COMPOSITE coating ,CELL adhesion ,SURFACE roughness - Abstract
Titanium implants are highly resistant to external forces and have affordable prices but the contact between Ti metal and surrounding native tissue could provoke an immunological response. The developing of biomimetic coating onto the Ti surface proves to be a smart choice to enhance the osseointegration and ensure an optimal healing process, due to the creation of nanostructured biomaterials like those in native bone. Thus, we designed a composite coating based on multi-substituted hydroxyapatite (noted ms-HAP or HAPc) nanoparticles, NPs, doped with essential elements: Mg, Zn and Si, functionalized with collagen type 1 (COL), embedded into poly lactic acid, PLA, matrix, and finally covered with COL layer to achieve biomimetic structures. Thin layers of biomimetic composite were self-assembled onto Ti surface via dip-coating method. Both, initial and coated Ti implants were investigated by atomic force microscopy (AFM), which allows surface investigation at high resolution of nano-level. COL amount in composite might self-assemble as COL fibers assuring a biomimetic structure, characterized by important features, like suitable porosity to facilitate the delivery of nutrients to osteoblasts and proper nano-topography and surface roughness to promote cell adhesion and proliferation. The outermost layer is of pure collagen which could assure a natural attachment to the bone tissue promoting osseo-integration. [ABSTRACT FROM AUTHOR]
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- 2021
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116. HIGUCHI MODEL APPLIED TO IONS RELEASE FROM HYDROXYAPATITES.
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MOCANU, AURORA, FRANGOPOL, PETRE T., BALINT, REKA, CADAR, OANA, VANCEA, IULIA MARIA, MINTĂU, ROZALIA, HOROVITZ, OSSI, and TOMOAIA-COTISEL, MARIA
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INDUCTIVELY coupled plasma atomic emission spectrometry ,PRECIPITATION (Chemistry) ,IONS - Abstract
In this study, the ions release of physiological elements from pure stoichiometric hydroxyapatite, HAP, and from multi-substituted hydroxyapatite, ms-HAPs, containing 1.5%Mg, 0.2%Zn, 0.2%Si and 5 %Sr, noted HAPc-5%Sr, and from HAPc-10%Sr, in water and in simulated body fluid, SBF, was studied by inductively coupled plasma optical emission spectrometry, ICP-OES, both in static and simulated dynamic regimes. The HAP and ms-HAP nanoparticles, NPs, were prepared by wet chemical precipitation and lyophilized powders were physicochemical characterized as presented elsewhere. The in vitro cations and anions release mechanism was investigated by applying a modified Higuchi model, which fits well the experimental results, particularly for simulated dynamic conditions. The predominant role of diffusion in the release of ions from the hydroxyapatites was confirmed. The sustained ions release from these nanomaterials recommends the investigated ms-HAPs for therapeutic applications. [ABSTRACT FROM AUTHOR]
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- 2021
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117. BIOCOMPATIBILITY OF TITANIUM IMPLANTS COATED WITH BIOCOMPOSITE IN A RAT MODEL OF FEMORAL FRACTURE.
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OLTEAN-DAN, DANIEL, FRANGOPOL, PETRE T., BALINT, REKA, TOMOAIA, GHEORGHE, MOCANU, AURORA, and TOMOAIA-COTISEL, MARIA
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FEMORAL fractures ,ANIMAL disease models ,SURFACE coatings ,LABORATORY rats ,BIOCOMPATIBILITY ,COMPACT bone - Abstract
The biocompatibility of uncoated titanium, Ti, nails and coated with an innovative biocomposite is assessed in a rat model of femoral fracture. The biocomposite is based on multi-substituted hydroxyapatite, ms-HAP containing Mg, Zn and Si, and is used as a coating material deposited on Ti implants, due to the excellent biocompatibility and osteoconductive property of ms-HAP. Specific focus has been given to biocomposite coating made of ms-HAP functionalized with collagen (ms-HAP/COL, core/shell nanoparticles) NPs embedded into poly lactic acid, PLA, matrix and finally covered by COL layer. This coating on Ti implants is noted as ms-HAP/COL@PLA/COL and named HAPc, and is characterized by SEM images and EDX spectra. Twenty-four Wistar albino rats with left femoral fracture, were used and divided in two equal groups, namely the control group, CG, with uncoated Ti implants and HAPc rat group with Ti implants coated with HAPc biocomposite through layer-by-layer, LBL, dip coating technique. After two- and eight-weeks postsurgery, they were evaluated by bone markers serum concentration, micro-CT and histological study. The alkaline phosphatase (ALP) and osteocalcin (OCN) expression, in the HAPc group showed higher values with an osteoblastic activity more intense and a more advanced callus stage. The micro-CT results showed that biocomposite coating significantly increased the bone volume/tissue volume (BV/TV). The most advanced stage of bone remodelling with osseointegration of the Ti implants was observed in HAPc group, where the new formed trabecular bone is almost completely replaced by compact bone. This study provides a novel strategy for the treatment of bone fracture with a superior osseointegration of biocomposite coated Ti implants and potential orthopaedic applications. [ABSTRACT FROM AUTHOR]
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- 2021
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118. Synthesis and structural characterization of novel porous zinc substituted nanohydroxyapatite powders
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Alexandra Carlea, Ioan Petean, Ossi Horovitz, Maria Sindilaru, Aurora Mocanu, Maria Tomoaia-Cotisel, Corina Garbo, Valer Almasan, and Gheorghe Tomoaia
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Materials science ,General Chemical Engineering ,Nucleation ,Mineralogy ,chemistry.chemical_element ,02 engineering and technology ,Zinc ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,stomatognathic system ,Pulmonary surfactant ,chemistry ,law ,Phase (matter) ,Calcination ,Crystallization ,Fourier transform infrared spectroscopy ,0210 nano-technology ,Porosity ,Nuclear chemistry - Abstract
This study reports the synthesis of new porous nanohydroxyapatites (HAPs) substituted with different Zn contents (HAP_Zn) employing calcium and zinc nitrates and diammonium hydrogen phosphate as precursors. The synthesis was conducted in the presence of a surfactant, L-asparagine, for controlling the pore size distribution and morphology of obtained nanopowders, using a co-precipitation route. Thus a new approach leading to HAP_Zn nanopowders with improved nucleation and crystallization ability was developed. After maturation treatment of dispersions and filtration, the precipitate was lyophilized and ground. Part of the samples was calcined at 300°C for 1 h. The zinc content in the nanoHAPs varies from 0.2 to 10 wt% (substitution degree of Ca by Zn from 0.3 to 15.8 mole %). XRD investigations indicated HAP as the unique phase present and the nanostructured nature of the obtained HAPs. FTIR spectra also confirmed the presence of HAP structure. TEM, SEM, and AFM images showed the morphology of the ...
- Published
- 2015
119. Do common metrics add value? Perspectives from NIH Clinical and Translational Science Awards (CTSA) Consortium hubs.
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Welch, Lisa C., Tomoaia-Cotisel, Andrada, Chang, Hong, Mendel, Peter, Etchegaray, Jason M., Qureshi, Nabeel, Fenwood-Hughes, Marguerite, Parajulee, Anshu, and Selker, Harry P.
- Abstract
Introduction: The Clinical and Translational Science Awards (CTSA) Consortium, a network of academic health care institutions with CTSA hubs, is charged with improving the national clinical and translational research enterprise. The CTSA Consortium and the NIH National Center for Advancing Translational Sciences implemented the Common Metrics Initiative comprised of standardized metrics and a shared performance improvement framework. This article summarizes hubs' perspectives on its value during the initial implementation. Methods: The value was assessed across 58 hubs. Survey items assessed change in perceived ability to manage performance and advance clinical and translational science. Semi-structured interviews elicited hubs' perspectives on meaningfulness and value-added of the Common Metrics Initiative and hubs' recommendations. Results: Hubs considered their abilities to manage performance to have improved, but there was no change in perceived ability to advance clinical and translational science. The initiative added value by providing a formal structured process, enabling strategic conversations, facilitating improvements in processes, providing an external impetus for improvement, and providing justification for funds invested. Hubs were concerned about the usefulness of the metrics chosen and whether the value-added was sufficient relative to the effort required. Hubs recommended useful benchmarking, disseminating best practices and promoting peer-to-peer learning, and expanding the use of data to inform the initiative. Conclusions: Implementing Common Metrics and a performance improvement framework yielded concrete short-term benefits, but concerns about usefulness remained, particularly considering the effort required. The Common Metrics Initiative should focus on facilitating cross-hub collaboration around metrics that address high-priority impact areas for individual hubs and the Consortium. [ABSTRACT FROM AUTHOR]
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- 2021
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120. Evaluation of initial progress to implement Common Metrics across the NIH Clinical and Translational Science Awards (CTSA) Consortium.
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Welch, Lisa C., Tomoaia-Cotisel, Andrada, Noubary, Farzad, Chang, Hong, Mendel, Peter, Parajulee, Anshu, Fenwood-Hughes, Marguerite, Etchegaray, Jason M., Qureshi, Nabeel, Chandler, Redonna, and Selker, Harry P.
- Abstract
Introduction: The Clinical and Translational Science Awards (CTSA) Consortium, about 60 National Institutes of Health (NIH)-supported CTSA hubs at academic health care institutions nationwide, is charged with improving the clinical and translational research enterprise. Together with the NIH National Center for Advancing Translational Sciences (NCATS), the Consortium implemented Common Metrics and a shared performance improvement framework. Methods: Initial implementation across hubs was assessed using quantitative and qualitative methods over a 19-month period. The primary outcome was implementation of three Common Metrics and the performance improvement framework. Challenges and facilitators were elicited. Results: Among 59 hubs with data, all began implementing Common Metrics, but about one-third had completed all activities for three metrics within the study period. The vast majority of hubs computed metric results and undertook activities to understand performance. Differences in completion appeared in developing and carrying out performance improvement plans. Seven key factors affected progress: hub size and resources, hub prior experience with performance management, alignment of local context with needs of the Common Metrics implementation, hub authority in the local institutional structure, hub engagement (including CTSA Principal Investigator involvement), stakeholder engagement, and attending training and coaching. Conclusions: Implementing Common Metrics and performance improvement in a large network of research-focused organizations proved feasible but required substantial time and resources. Considerable heterogeneity across hubs in data systems, existing processes and personnel, organizational structures, and local priorities of home institutions created disparate experiences across hubs. Future metric-based performance management initiatives across heterogeneous local contexts should anticipate and account for these types of differences. [ABSTRACT FROM AUTHOR]
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- 2021
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121. The effect of granulate porosity on the evolution of the thermal conductivity of an resin concrete exposed to high temperatures.
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imane, Benoudjafer, ibtissam, Benoudjafer, and Maria, Tomoaia-Cotisel
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THERMAL conductivity ,HIGH temperatures ,REINFORCED concrete ,CONCRETE ,CONCRETE testing ,EFFECT of temperature on concrete ,POROSITY - Abstract
As the aggregates occupy about three-quarters of the volume of concrete, it’s not surprising that their properties can, not only, to limit its resistance, but also to affect the durability and structural performance of concrete. In this context, the study's main objective to study the influence of the aggregate porosity on the evolution of the thermal conductivity of a resin concrete exposed to high temperatures. the experimental results show that the porosity of the aggregates has a significant influence on the evolution of the thermal conductivity of the concretes tested. [ABSTRACT FROM AUTHOR]
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- 2021
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122. Practice Expenses Associated with Comprehensive Primary Care Capabilities
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Grant R. Martsolf, Andrada Tomoaia-Cotisel, Peter Mendel, Ryan K. McBain, Nabeel Qureshi, Peter S. Hussey, Jason M. Etchegaray, Ryan Kandrack, Mark W. Friedberg, Laura Raaen, and Brian Briscombe
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Estimation ,Actuarial science ,Cost estimate ,Workbook ,Health Policy and Health Economics ,Scale (social sciences) ,Service level ,Business ,Empirical evidence ,Medicaid ,Diversity (business) - Abstract
Through the Comprehensive Primary Care (CPC) and Comprehensive Primary Care Plus (CPC+) programs, the Centers for Medicare & Medicaid Services (CMS) has encouraged primary care practices to invest in “comprehensive primary care” capabilities. Empirical evidence suggests these capabilities are under-reimbursed or not reimbursed under prevailing fee-for-service payment models. To help CMS design alternative payment models (APMs) that reimburse the costs of these capabilities, the authors developed a method for estimating related practice expenses. Fifty practices, sampled for diversity across CPC+ participation status, geographic region, rural status, size, and parent-organization affiliation, completed the study. Researchers developed a mixed-methods strategy, beginning with interviews of practice leaders to identify their capabilities and the types of costs incurred. This was followed by researcher-assisted completion of a workbook tailored to each practice, which gathered related labor and nonlabor costs. In a final interview, practice leaders reviewed cost estimates and made any needed corrections before approval. A main goal was to address a persistent question faced by CMS: When practices reported widely divergent costs for a given capability, was that divergence due to practices having different prices for the same capability or from their having substantially different capabilities? The cost estimation method developed in this project collected detailed data on practice capabilities and their costs. However, the small sample did not allow quantitative estimation of the contributions of service level and pricing to the variation in overall costs. This cost estimation method, deployed on a larger scale, could generate robust data to inform new payment models aimed at incentivizing and sustaining comprehensive primary care.
- Published
- 2018
123. The Journey toward the Patient-Centered Medical Home: A Grounded, Dynamic Theory of Primary Care Transformation
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Tomoaia-cotisel, Andrada, Blanchet, Karl, and Chalabi, Zaid
- Abstract
Introduction: This dissertation develops a grounded and dynamic theory of primary care transformation (PCT) in a health service delivery organization (HSDO) implementing the Patient-Centered Medical Home model, in the United States of America. The focus of this theory is on the structural facilitators and challenges to achieving and sustaining high quality primary care. Methodology: Fieldwork performed included semi-structured interviews conducted across the HSDO (n=82), direct observations (n=10 clinics) and archival review. This dissertation utilizes newly-developed methods for theory development and validation, in concert with existing system dynamics methods; with an improved potential to integrate findings across quantitative and qualitative research directions. Results: My theory illuminates how the actions of various stakeholders (medical assistants, managers, clinicians and patients) interact with each other and with the fundamental characteristics of primary care service delivery to create diverse transformation trajectories. Two types of leverage points are identified: policies and preferences. The latter are more difficult to modify as they require changing stakeholders’ mental models. It is the combination of policies and preferences interacting within the system structure that produces hoped-for and feared transformation trajectories. There is no policy that induces success regardless of stakeholder preferences. There are some preferences that induce success or failure regardless of the policies being implemented. Conclusion: Sustaining success requires understanding the system structure within which policies and preferences operate – how decisions are made, their consequences, and the delays involved. Otherwise, transformation risks being overwhelmed by unintended consequences, misunderstood system behavior or impatience. This work presents an improved understanding of what PCT involves, and of how operational and cognitive aspects intersect. Overall, this work is more than a study of transformation. It presents theory, methods and a case for the development of an integrative methodology and paradigm.
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- 2018
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124. In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites
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Rapuntean, Sorin, primary, Frangopol, Petre T., additional, Hodisan, Ioana, additional, Tomoaia, Gheorghe, additional, Oltean-Dan, Daniel, additional, Mocanu, Aurora, additional, Prejmerean, Cristina, additional, Soritau, Olga, additional, Racz, Levente Zsolt, additional, and Tomoaia-Cotisel, Maria, additional
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- 2019
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125. Mössbauer study of novel iron(II) complexes synthesized with Schiff bases
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P. Huszthy, L.-M. Golban, Firuta Goga, Maria Várhelyi, Erno Kuzmann, Roland Szalay, Cs. Várhelyi, J. Papp, Imre Miklós Szilágyi, Á. Szőke, Maria Tomoaia-Cotisel, Attila Lengyel, Zoltán Homonnay, and Gy. Pokol
- Subjects
Nuclear and High Energy Physics ,Ethylene ,Chemistry ,Infrared spectroscopy ,010402 general chemistry ,010403 inorganic & nuclear chemistry ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Crystallography ,chemistry.chemical_compound ,Differential thermal analysis ,Mössbauer spectroscopy ,X-ray crystallography ,Physical and Theoretical Chemistry ,Fourier transform infrared spectroscopy ,Cyclic voltammetry ,Thermal analysis - Abstract
Novel [Fe(4-benzyl-2-hydroxyphenyl-propylidene)2ethylene-diamine], and [Fe (2,4,6-trihydroxy-benzyl-4-metoxiphenyl-methylidene)2ethylene-diamine] complexes were synthesized by reacting FeII salt with the indicated Schiff-base ligands. The compounds were characterized by57Fe Mossbauer spectroscopy, FTIR, UV-VIS, TG-DTA-DTG, MS, AFM, XRD, cyclic voltammetry and biological activity measurements. 295 K and 78 K Mossbauer spectra revealed that iron is dominantly in high spin FeII state in both complexes while simultaneously a minor low spin FeII was also present in both complexes, furthermore a minor high spin FeIII was observed in [Fe(2,4,6-trihydroxy-benzyl-4-metoxiphenyl- methylidene) 2ethylene-diamine], too.
- Published
- 2017
126. Atmospheric induced nanoparticles due to the urban street dust
- Author
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Dana Florina Muntean, Ioan Petean, Maria Tomoaia-Cotisel, Alexandra Gertrud Paltinean, George Arghir, and Liviu-Dorel Bobos
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Calcite ,Materials science ,010504 meteorology & atmospheric sciences ,General Chemical Engineering ,Muscovite ,Energy-dispersive X-ray spectroscopy ,Mineralogy ,Nanoparticle ,010501 environmental sciences ,engineering.material ,01 natural sciences ,chemistry.chemical_compound ,chemistry ,engineering ,Kaolinite ,Lepidocrocite ,Quartz ,Scherrer equation ,0105 earth and related environmental sciences - Abstract
Urban street dust (SD) represents a natural source of mineral floating particles (FP) in the atmosphere. The FP particles have usually a wide range of sizes. These particles were monitored and collected by automatic stations in Cluj-Napoca, Romania. The SD and FP samples were investigated by XRD and SEM-EDX analysis. The obtained results prove that both, SD and FP, have a similar composition, namely quartz, clay particles (e.g., muscovite, and kaolinite), calcite, and trace of lepidocrocite. Nanostructural features and fine micro-scaled particles are observed. Quartz and clay nanoparticles were found in SD samples as well as in FP samples. The AFM investigation reveals a nano-size range for quartz particles between 80–90 nm, and 40–60 nm diameter for clay particles. Similar values were obtained by TEM microscopy. The high resolution microscopy results were confirmed by the values obtained by Scherrer formula applied to the XRD patterns. Composition and dimensional similarities found for the nanopa...
- Published
- 2015
127. Nano forsterite biocomposites for medical applications: Mechanical properties and bioactivity
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Ovidiu Pana, Maria Gorea, Gabriel Furtos, Cristina Prejmerean, Maria Tomoaia-Cotisel, Marieta-Adriana Naghiu, and Heidi Declercq
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Materials science ,Flexural modulus ,Simulated body fluid ,Biomedical Engineering ,02 engineering and technology ,Forsterite ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Biomaterials ,Compressive strength ,Flexural strength ,Nano ,Volume fraction ,Ultimate tensile strength ,engineering ,Composite material ,0210 nano-technology - Abstract
The aim of the present study was to obtain and to investigate nano forsterite and nano forsterite biocomposites for biomedical application. New self-curing forsterite biocomposites were obtained by mixing nano forsterite powder (5, 15, 30, 50, 70 wt %) with 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]propane (bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA) monomers. The new nano forsterite biocomposites were investigated for mechanical properties: compressive strength (CS) (143-147.12 MPa), compressive modulus (CM) (1.67-2.75 GPa), diametral tensile strength (DTS) (27.33-31.55 MPa), flexural strength (FS) (59.47-83.20 MPa) and flexural modulus (FM) (2.05-8.60 GPa). Increases of CS, DTS, FS with increasing amount of forsterite were observed up to 50 wt %. The highest CM and FM values were registered for 70 wt % and a direct correlation between the forsterite volume fraction (%) was observed. SEM micrographs revealed the morphology of surface of fractured biocomposites after CS test. XPS indicated that these biocomposites promoted the hydroxyapatite formation on their surface immersed in simulated body fluid (SBF). AFM images showed that the growth of the hydroxyapatite layer occurs with a preferred orientation on the surface of forsterite biocomposites after immersion in SBF. Incorporation of nano forsterite in the polymer matrix (bis-GMA/TEGDMA) did show osteoblast adhesion and proliferation was improved on nano forsterite biocomposites. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1290-1301, 2016.
- Published
- 2015
128. Preparation and characterization of novel [Fe(methylisopropylglyoximato)2(amine)2] mixed chelates
- Author
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Ernő Kuzmann, Roland Szalay, Firuta Goga, Maria Tomoaia-Cotisel, Eniko Covaci, Aderbal C. Oliveira, V. Izvekov, Attila Lengyel, Cs. Várhelyi, A. Kun, Gy. Pokol, Zoltán Homonnay, and Vijayendra K. Garg
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chemistry.chemical_classification ,Health, Toxicology and Mutagenesis ,Inorganic chemistry ,Public Health, Environmental and Occupational Health ,Branching (polymer chemistry) ,Pollution ,Analytical Chemistry ,Bond length ,chemistry.chemical_compound ,Nuclear Energy and Engineering ,chemistry ,Polymer chemistry ,Mössbauer spectroscopy ,Pyridine ,Moiety ,Radiology, Nuclear Medicine and imaging ,Amine gas treating ,Spectroscopy ,Alkyl ,Isopropyl - Abstract
A series of novel [Fe(MeiPrGlyoxH)2(amine)2] complexes have been synthesized [(MeiPrGlyoxH2 = methylisopropylglyoxime, amine = 3,5-dimethylpyridine, 4-(dimethylamino)pyridine, 4-(phenylamino)phenol, 2-imidazolidone)] and characterized by 57Fe Mossbauer, FTIR, UV–Vis spectroscopy, mass spectrometry, AFM and thermoanalytical methods. Quantum chemical (DFT) computations of [Fe(MeiPrGlyoxH)2(3,5-dimethyl-Py)2] (Py = pyridine) complex were also performed. The square-planar structure of [Fe(MeiPrGlyoxH)2] moiety is similar to that of [Fe(MeEtGlyoxH)2]. The incorporation of branching alkyl chains (isopropyl) in the complexes alters the Fe–N bond length and results in high-spin iron(II) state.
- Published
- 2014
129. A NEW METHOD FOR SYNTHESIS OF FORSTERITE NANOMATERIALS FOR BIOIMPLANTS
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Naghiu, M. A., Gorea, M., Kristaly, F., and Maria Tomoaia-Cotisel
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lcsh:TP785-869 ,Magnesium silicates ,lcsh:Clay industries. Ceramics. Glass ,Precipitation method ,Particle size ,Thermal analysis ,Biomaterial - Abstract
Nanocrystalline forsterite (Mg2SiO4) was synthesized by the precipitation method using Mg(NO3)2∙6H2O, C8H20O4Si (TEOS) and sodium hydroxide as pH regulator as starting materials. The thermal behaviour of the mixture was investigated by a MOM derivatograh. According to DTA results the initial crystallization temperature of the forsterite is about 800oC. The powder calcined at 900oC was characterized by X ray diffraction (XRD). The forsterite was noticed as the main crystalline phase besides of small amounts of periclase (MgO). Polycrystalline forsterite with uniform sized particles and spherical shape is evidenced by electronic microscopy (TEM, SEM). Grain size of forsterite powder according to Counter Coulter-type laser granulometer results is in the range of 10 - 42 nm.
- Published
- 2014
130. The Effect of Globular Protein from Aleurone Cells of Barley on Stearic Acid Monolayers
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Cojocaru, Ileana, primary, Tomoaia Cotisel, Andrada, additional, Mocanu, Aurora, additional, Yupsanis, Traianos, additional, and Tomoaia Cotisel, Maria, additional
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- 2017
- Full Text
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131. Patient care experiences and perceptions of the patient-provider relationship: A mixed method study
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Jennifer Tabler, Debra L. Scammon, Jaewhan Kim, Timothy Farrell, Andrada Tomoaia-Cotisel, and Michael K. Magill
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Medicine (General) ,medicine.medical_specialty ,patient satisfaction ,mixed methods ,interpersonal continuity of care ,General Mathematics ,media_common.quotation_subject ,Interpersonal communication ,Logistic regression ,Patient-provider relationship ,R5-920 ,Patient satisfaction ,Nursing ,patient centered medical home ,Perception ,Patient experience ,medicine ,media_common ,patient experience ,communication ,business.industry ,Applied Mathematics ,Medical record ,patient-provider relationship ,Focus group ,Family medicine ,Public aspects of medicine ,RA1-1270 ,business - Abstract
Improving interpersonal continuity of care—the personal relationship forged between a patient and their primary care provider (PCP) over time—is often considered a goal of primary care. Continuity of care is frequently assessed in terms of longitudinal continuity, or the proportion of encounters with one practitioner, overlooking aspects of the patient-provider relationship that are key to interpersonal continuity of care. Further, few studies explore patients’ perspectives regarding which care experiences enhance or detract from the patient-provider relationship. This study, using focus group interviews, a patient experience CAHPS-PCMH survey, and electronic medical records, explored how patients’ experiences at 10 primary care clinics influenced their perceptions of their relationship with their PCPs. Focus group interviews with 63 participants indicated that patients’ experiences in the clinics, such as wait-times, influenced their perceptions of the patient-provider relationship. The relationship between patient experience and interpersonal continuity was empirically assessed using survey responses and medical records (n=645). We used patients’ perceptions that their provider knows them as a person as a measure of interpersonal continuity. Logistic regression results indicated that being seen within 15 minutes, receiving visit reminders, effective provider communication, and satisfaction, positively influenced patient perceptions of the patient-provider relationship. Furthermore, patients’ care experiences shaped their perceptions of the patient-provider relationship independent of their satisfaction with care. The mixed methods design adds depth to our understanding of patients’ care experiences, and illustrates that these experiences are critical for understanding the patient-provider relationship. Future research on interpersonal continuity should take patient experiences into account.
- Published
- 2014
132. Synthesis; characterization and antimicrobial effects of composites based on multi-substituted hydroxyapatite and silver nanoparticles
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Gabriel Furtos, Chirilă Flore, Ossi Horovitz, Cristina Prejmerean, Maria Tomoaia-Cotisel, Ancuta Danisteanu, Corina Garbo, Sorin Rapuntean, Aurora Mocanu, and Gheorghe Rapuntean
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Materials science ,technology, industry, and agriculture ,General Physics and Astronomy ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,Zinc ,engineering.material ,Condensed Matter Physics ,Silver nanoparticle ,Surfaces, Coatings and Films ,law.invention ,chemistry.chemical_compound ,Silver nitrate ,Monomer ,stomatognathic system ,Coating ,chemistry ,law ,Nano ,engineering ,Calcination ,Fourier transform infrared spectroscopy ,Composite material - Abstract
Nano hydroxyapatite doped with zinc (0.2 wt%), silver (0.25 wt%) and gold (0.025 wt%), (HAP), has been obtained by an innovative wet chemical approach, coupled with a reduction process for silver and gold. The synthesized multi-substituted nano HAP was freeze-dried and calcined at 650 °C. Nano HAP has been characterized by XRD, FTIR spectroscopy and imaging techniques: TEM, SEM and AFM. Then, nano HAP was mixed with previously synthesized silver nanoparticles (AgNPs), in the amount of 9 wt%, to give a novel material (HAP-Ag). The AgNPs were prepared by the reduction of silver nitrate with glucose in alkaline medium. TEM and UV–Vis confirmed the formation of AgNPs with an average size of 12 nm. Further, organic matrix composites were obtained from a filler made of HAP and/or HAP-Ag and a mixture of monomers (such as bis-GMA and TEG-DMA), which were polymerized at various compositions in AgNPs content up to 5.4 wt%. Antibacterial activities of these composites were investigated against several different pathogenic species: Escherichia coli, Staphylococcus aureus, Staphylococcus spp., Bacillus cereus, and Candida albicans, using the Kirby–Bauer disk-diffusion method. Antibacterial activities are enhanced with increasing of silver content within composites. These effects clearly reveal that AgNPs can be effectively utilized in combination with multi-substituted HAP and polymeric matrix, both used as carriers, in order to improve their efficiency against various pathogenic species. These composites can be considered a promising antimicrobial material for coating of orthopedic and dental implants or used as bone cements in surgical applications.
- Published
- 2014
133. Silicon effect on the composition and structure of nanocalcium phosphates
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Aurora Mocanu, Ioan Vida-Simiti, O. Soritau, Maria Tomoaia-Cotisel, Nicolae Jumate, Liviu-Dorel Bobos, and Gheorghe Tomoaia
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Materials science ,Silicon ,Biocompatibility ,Scanning electron microscope ,Mineralogy ,chemistry.chemical_element ,Bioengineering ,Nanocrystalline material ,law.invention ,Biomaterials ,stomatognathic system ,chemistry ,Chemical engineering ,Mechanics of Materials ,law ,Transmission electron microscopy ,Calcination ,Crystallite ,Fourier transform infrared spectroscopy - Abstract
Nanostructured calcium phosphates, such as nanohydroxyapatite (HAP) and HAP with silicon content (HAP-Si) of 0.47wt.% (1% SiO2), 2.34wt.% (5% SiO2) and 4.67wt.% (10% SiO2) in the final product, were synthesized by aqueous precipitation, freeze dried and then calcined at 650, 950 and 1150°C. The obtained materials were investigated by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectrometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM) imaging. From the analysis of the XRD patterns, the HAP and β-tricalcium phosphate (β-TCP) phases were identified and their amounts in the samples were estimated. The size of HAP and β-TCP crystallites was estimated to be in the nanocrystalline domain. FTIR spectra showed the presence of characteristic vibrations for P-O, H-O and Si-O groups and their modification with Si content and calcination temperature. TEM, SEM and AFM images also revealed the morphology of the particles and of their aggregates. These materials have been used to manufacture scaffolds which were tested for their influence on adhesion and proliferation of cells, in human osteoblast culture, considering their further use in bone reconstruction. It was found that an appropriate addition of silicon in nanocalcium phosphate scaffolds leads to an enhanced adhesion and proliferation of cells in osteoblasts in vitro.
- Published
- 2014
134. Biogenic Syntheses of Gold Nanoparticles Using Plant Extracts
- Author
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Ossi Horovitz, Maria Tomoaia-Cotisel, Ioan Petean, Roxana-Diana Pasca, Aurora Mocanu, and Simona-Codruta Cobzac
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chemistry.chemical_compound ,Colloid ,Ultraviolet visible spectroscopy ,chemistry ,Reducing agent ,Polyphenol ,Colloidal gold ,Transmission electron microscopy ,General Chemical Engineering ,Chloroauric acid ,Analytical chemistry ,Fourier transform infrared spectroscopy ,Nuclear chemistry - Abstract
A biogenic approach for the synthesis of gold nanoparticles (GNPs) by reducing chloroauric acid (HAuCl4) with three different plant extracts (from Angelica, Hypericum, and Hamamelis) is described. The content of reducing compounds (polyphenols) in each plant extract was determined by photometric dosing. The formation of GNPs was tracked by ultraviolet-visible spectroscopy and their characterization was performed using transmission electron microscopy (TEM) and atomic force microscopy (AFM) imaging and FTIR spectra. GNPs, with diameters ranging from about 4 nm to 8 nm, were obtained at room temperature and pH value about 8. They present various shapes from spherical, to ovals, heart or polyhedral forms. Generally, the GNPs colloidal dispersions are rather stable in time, and the self assembly of GNPs is sparsely observed. However, at lower concentration of the plant extract the tendency to self aggregation of the GNPs increased. The plant extracts contain reducing agents, compounds with stabilizing effect ...
- Published
- 2014
135. In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites
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Ioana Hodisan, Cristina Prejmerean, Petre T. Frangopol, Sorin Rapuntean, Gheorghe Tomoaia, Daniel Oltean-Dan, Maria Tomoaia-Cotisel, Levente Zsolt Racz, Olga Soritau, and Aurora Mocanu
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Strontium ,Materials science ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,chemistry.chemical_element ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,In vitro ,stomatognathic system ,chemistry ,Materials Chemistry ,Hydroxyapatites ,General Pharmacology, Toxicology and Pharmaceutics ,Nuclear chemistry - Abstract
The goal of this study was to analyze the response of osteoblasts cultured on strontium substituted hydroxyapatites (HAP-Sr) of well-defined high crystallinity deposited as thin films on glass plates. Up to now, this aspect has not been carefully investigated in the context of bio-ceramics. In this study, we present the osteoblasts activity on synthesized HAP-Sr for different amounts of strontium substitution for calcium within the hydroxyapatite (Ca10(PO4)6(OH)2, HAP) lattice, namely HAP-5%Sr, HAP-10%Sr, HAP-15%Sr and HAP-59.2%Sr (Sr-HAP, of formula Sr10(PO4)6(OH)2), in comparison with stoichiometric pure HAP, chosen as control. Each bio-ceramic was deposited as thin multilayers self-assembled substrate (scaffold) and chemically bonded to the surface of glass plates. These coatings revealed by AFM and SEM imaging a granular texture formed from bio-ceramic nanoparticles. They possessed a high degree of crystallinity, i.e. 68% to 86%, depending on the Sr amount within the HAP lattice, as judged by XRD. Osteoblasts were cultured up to 21days and displayed enhanced adhesion and proliferation particularly evidenced on relatively high strontium contents (especially 5 and 10 weight %, determined by SEM-EDX), where the alkaline phosphatase activity and type I collagen were strongly evidenced. These bio-ceramics showed a high in vitro biocompatibility stimulating the activity of osteoblasts in the process of bone formation. These nano biomaterials can have applications in orthopedic and dental surgery improving the osteointegration as coatings of bone implants as well as for bone repair and regeneration.
- Published
- 2019
136. Creating a comprehensive, unit-based approach to detecting and preventing harm in the neonatal intensive care unit
- Author
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Sedlock, Emily W, primary, Ottosen, Madelene, additional, Nether, Klaus, additional, Sittig, Dean F., additional, Etchegaray, Jason M, additional, Tomoaia-Cotisel, Andrada, additional, Francis, Nicole, additional, Yager, Lauren, additional, Schafer, Leslie, additional, Wilkinson, Rebekah, additional, Khan, Amir, additional, Arnold, Cody, additional, Davidson, Allison, additional, and Thomas, Eric J, additional
- Published
- 2018
- Full Text
- View/download PDF
137. Behavior of Doped Hydroxyapatites During the Heat Treatment
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Goga, Firuta, primary, Forizs, Edit, additional, Borodi, George, additional, Tomoaia, Gheorghe, additional, Avram, Alexandra, additional, Balint, Reka, additional, Mocanu, Aurora, additional, Horovitz, Ossi, additional, and Tomoaia Cotisel, Maria, additional
- Published
- 2018
- Full Text
- View/download PDF
138. Mössbauer study of novel iron(II) complexes synthesized with Schiff bases
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Várhelyi, Cs., primary, Lengyel, A., additional, Homonnay, Z., additional, Szalay, R., additional, Pokol, Gy., additional, Szilágyi, I.-M., additional, Huszthy, P., additional, Papp, J., additional, Goga, F., additional, Golban, L.-M., additional, Várhelyi, M., additional, Tomoaia-Cotisel, M., additional, Szőke, Á., additional, and Kuzmann, E., additional
- Published
- 2017
- Full Text
- View/download PDF
139. Adsorption kinetics of some carotenoids at the oil/water interface
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Maria Tomoaia-Cotisel, Andrada Tomoaia-Cotisel, Paul Joos, and Andrew J. Sellers
- Subjects
Surface Properties ,Diffusion ,Kinetics ,Colloid and Surface Chemistry ,Adsorption ,Pulmonary surfactant ,Phase (matter) ,Molecule ,Organic chemistry ,Physical and Theoretical Chemistry ,Biology ,Carotenoid ,chemistry.chemical_classification ,Physics ,Relaxation (NMR) ,Water ,food and beverages ,Surfaces and Interfaces ,General Medicine ,Models, Theoretical ,beta Carotene ,Carotenoids ,Chemistry ,chemistry ,Chemical engineering ,Oils ,Biotechnology - Abstract
The kinetic analysis of the adsorption of two carotenoids (i.e., ethyl ester of beta-apo-8'-carotenoic acid and beta-carotene, all trans-isomers) from n-hexane solutions at the oil/water interface is presented for several carotenoid concentrations in the oil phase. A new kinetic approach is developed and it addresses the diffusion adsorption associated with a reversible interfacial reaction, which describes the reorientation of surfactant molecules between two conformations. This approach leads to a general analytical expression that contains four physical parameters and describes with high accuracy the experimental dynamic interfacial tensions for the two carotenoids, which independently adsorb from n-hexane phase to the n-hexane/water interface. The calculations give the characteristic times for the carotenoid adsorption at the oil/water interface in terms of diffusion relaxation and kinetic relaxation times. The results explain the long time effects on the adsorption of these carotenoids at the oil/water interface. The data are in substantial agreement with the molecular structure of these carotenoids and with the earlier data recorded for cholesterol adsorption at the n-heptane/water interface. Based on these findings, we propose a molecular mechanism for the interfacial transformation of carotenoid molecules at a hydrophobic/hydrophilic interface. (C) 2004 Elsevier B.V. All rights reserved.
- Published
- 2004
140. Acid dissociation constants of diphytanylglycerolphosphorylglycerol-methylphosphate, and diphytanylglycerolphosphorylglycerophosphate and its deoxy analog
- Author
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Tomoaia-Cotisel, Maria, Stewart, Laura C., Kates, Morris, Zsako, Janos, Chifu, Emil, Mocanu, Aurora, Frangopol, Petre T., Noe, Lewis J., and Quinn, Peter J.
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- 1999
- Full Text
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141. New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
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Mocanu A, Pasca RD, Tomoaia G, Garbo C, Frangopol PT, Horovitz O, and Tomoaia-Cotisel M
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Medicine (General) ,R5-920 - Abstract
Aurora Mocanu,1 Roxana Diana Pasca,1 Gheorghe Tomoaia,2 Corina Garbo,1 Petre T Frangopol,1 Ossi Horovitz,1 Maria Tomoaia-Cotisel11Chemical Engineering Department, Babes-Bolyai University, 2Orthopedic Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaAbstract: Silver nanoparticles (AgNPs) were prepared in aqueous colloid dispersions by the reduction of Ag+ with glucose in alkaline medium. Tetraethyl orthosilicate and l-asparagine were added as stabilizers of NPs. The AgNPs were characterized, and their interaction with three local anesthetics (procaine, dibucaine, or tetracaine) was investigated. Optical spectra show the characteristic absorption band of AgNPs, due to surface plasmon resonance. Modifications in the position and shape of this band reflect the self-assembly of metal NPs mediated by anesthetic molecules and the progress in time of the aggregation process. Zeta-potential measuring was applied in order to characterize the electrostatic stability of the NPs. The size and shape of the AgNPs, as well as the features of the assemblies formed by their association in the presence of anesthetics, were evidenced by transmission electron microscopy images. Atomic force microscopy images showed the characteristics of the films of AgNPs deposited on glass support. The effect of the anesthetics could be described in terms of electrostatic forces between the negatively charged AgNPs and the anesthetic molecules, existing also in their cationic form at the working pH. But also hydrophobic and hydrogen bonding interactions between the coated nanoparticles and anesthetics molecular species should be considered.Keywords: self-assembled nanostructures, UV-vis spectra, TEM, AFM, zeta potential
- Published
- 2013
142. New Composite Bone Cement Based on Hydroxyapatite and Nanosilver
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Ioan Vida-Simiti, Cristina Prejmerean, Gabriel Furtos, Nicolaie Jumate, Maria Tomoaia-Cotisel, Marin Senila, and Corina Garbo
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Cement ,chemistry.chemical_classification ,Liquid ratio ,Compressive strength ,Materials science ,chemistry ,General Chemical Engineering ,Radiodensity ,Composite number ,Total joint replacement ,Polymer ,Composite material ,Bone cement - Abstract
Although total joint replacement surgery has become common in recent years, problems due to bacterial infection remain a significant complication following this procedure. One approach in our study was to obtain a self-cured bone cement based on hydroxyapatite with nanosilver (Hap-Ag) and ZrO2 and polymer matrix based on 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]propane/triethyleneglycol dimethacrylate. New materials were tested for: in vitro silver release, compressive strength (CS), compressive modulus (CM), and radiopacity. In vitro silver release increased in time and depended of silver content in cement. The highest silver release was registered for the cement with 1.26 wt% silver content. The results reveal that the CS for bone cement was between 133.37 and 146.70 MPa and CM was between 1.68 and 1.82 GPa (p > 0.05). A slow increasing of CM was registered for samples with 1.5/1 powder/liquid ratio. Addition of nanosilver and ZrO2 increased radiopacity of experimental bone cement.
- Published
- 2013
143. Resin Composites Reinforced by Glass Fibers with Potential Biomedical Applications. Structure and Mechanical Properties
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Gabriel Furtos, Cristina Prejmerean, and Maria Tomoaia-Cotisel
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chemistry.chemical_compound ,Materials science ,Compressive strength ,chemistry ,Flexural strength ,Propane ,Scanning electron microscope ,Flexural modulus ,General Chemical Engineering ,Glass fiber ,Surface roughness ,Fiber ,Composite material - Abstract
A series of new biomedical resin composites based on 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]propane/triethyleneglycol dimethacrylate resin reinforced with alkaline resistant (AR) glass fibers and BaSO4 powder in different ratios were prepared. The mechanical properties—that is, compressive strength (CS), flexural strength (FS), and flexural modulus (FM)—were determined. The results showed an increase of FS and FM and a slight decrease of CS with an increasing amount of glass fibers. Results revealed that CS increases in the following order: light-curing composites < self-curing composites < dual-curing composites. Structure of the resin composites were investigated by scanning electron microscopy of the fractured surface of composites after the FS test at different fiber amounts. Atomic force microscopy images of the polished surface of composites showed an increasing surface roughness with increasing filler content.
- Published
- 2013
144. Forsterite Nanopowder: Structural Characterization and Biocompatibility Evaluation
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Maria Gorea, Maria Tomoaia-Cotisel, Elaine Mutch, Marieta-Adriana Naghiu, and Ferenc Kristály
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Materials science ,Polymers and Plastics ,Biocompatibility ,Mechanical Engineering ,Metals and Alloys ,Nanoparticle ,Mineralogy ,Forsterite ,engineering.material ,Grain size ,Chemical engineering ,Mechanics of Materials ,Phase (matter) ,Materials Chemistry ,Ceramics and Composites ,engineering ,Crystallite ,Periclase ,Dissolution - Abstract
Forsterite, a new biocompatible material was synthesized from Mg(NO3)2·6H2O and TEOS by using the sol–gel method. The material was then heated at 800, 900 and 1000 °C. The forsterite was noticed as the main crystalline phase in the material fired at 900 and 1000 °C, while periclase (MgO) was present in all the samples. The tests confirm that in the first two samples forsterite is present as crystallites
- Published
- 2013
145. OPLC separation and identification of some amino acids from different proteins
- Author
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Maria Tomoaia-Cotisel, Aurora Mocanu, Florina Copaciu, Mihaela Vlassa, Miuţa Filip, and Virginia Coman
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chemistry.chemical_classification ,food.ingredient ,Chromatography ,biology ,Clinical Biochemistry ,Lysine ,Biochemistry ,Analytical Chemistry ,Amino acid ,Hydrolysis ,chemistry.chemical_compound ,food ,chemistry ,Yolk ,Ninhydrin ,biology.protein ,Bovine serum albumin ,Derivatization ,Histidine - Abstract
The basic of all proteins is constituted by approximately 20 common amino acids that differ only in the structure of their side chain. The purpose of our work was to use the overpressured layer chromatography (OPLC) technique for the separation and identification of the essential and non-essential amino acids from some most common proteins, like hen egg yolk protein, bovine serum albumin (BSA), and Type I Collagen from bovine achilles tendon. In this order, the target proteins were acid-hydrolyzed and derivatized. For the separation of essential amino acids from egg yolk, two successive OPLC developments (normal and overrunning) were performed, followed by direct derivatization with 4-hydroxybenzaldehyde and ninhydrin on the chromatoplate for identification. In the hydrolyzed egg yolk, nine essential amino acids were identified. Between lysine and histidine, a poor separation was obtained. The amino acids from BSA and Type I Collagen were separated and identified as phenylthiohydantoin (PTH) derivatives b...
- Published
- 2013
146. Scaffolds made of nanostructured phosphates, collagen and chitosan for cell culture
- Author
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Maria Tomoaia-Cotisel, Ossi Horovitz, Liviu-Dorel Bobos, Gheorghe Tomoaia, A. Pop, O. Soritau, L.-B. Pop, and Aurora Mocanu
- Subjects
Nanostructure ,Materials science ,General Chemical Engineering ,Layer by layer ,Nanoparticle ,Bone tissue ,Chitosan ,Crystallinity ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Chemical engineering ,medicine ,Hydroxyapatites ,Biocomposite ,Biomedical engineering - Abstract
In the present study a new strategy of synthesis was developed for nanostructured calcium phosphates, such as hydroxyapatite (HAP) or silicon, magnesium and zinc modified hydroxyapatites of controlled characteristics (such as the shape and size of nanoparticles, porosity and crystallinity) by precipitation reactions. These inorganic powders were jointly used with chitosan (CHI) and collagen type I (COL) to manufacture fibrous biocomposite scaffolds made of self-assembled layers by using layer by layer technique for cell cultures. The resulting materials were characterized by using X-ray diffraction, SEM, TEM and AFM. This work also reports the structural data obtained on the surface of the newly prepared nanostructured porous scaffolds made of self-assembled nanoHAP–Si(0.2%)–Mg(0.6%)–Zn(0.2%)/CHI/COL layers at 7 days in human osteoblastic cell culture. A new porous structure was found by SEM imaging on the surface of these scaffolds due to the cells and scaffold interactions. This structure is apparently similar to the bone tissue. Our data have indicated that the incorporation of small amounts of silicon, magnesium and zinc within the nanoHAP lattice improved the biological activity of human osteoblasts on these scaffolds, in vitro. The data have revealed the high importance of HAP nanostructure and its composition in the preparation of fibrous scaffolds with potential applications in particle technology, bone tissue engineering and nano medicine.
- Published
- 2013
147. Collapse Mechanism of some Carotenoid Monomolecular Films - Membrane Model
- Author
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Tomoaia-Cotişel, Maria, Zsako, J., Chifu, E., Cadenhead, D. A., Ries, H. E., Jr., and Biggins, J., editor
- Published
- 1987
- Full Text
- View/download PDF
148. The Structure of Some Lecithin Monolayers at the Air/Water Interface
- Author
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Tomoaia-Cotişel, Maria, Chifu, Emil, Zsakó, János, Pullman, Alberte, editor, Vasilescu, V., editor, and Packer, L., editor
- Published
- 1985
- Full Text
- View/download PDF
149. Discussion of Compression Isotherms of some Carotenoid Monolayers on the Basis of HMO Calculations
- Author
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Zsakó, J., Tomoaia-Cotişel, M., Chifu, E., and Mittal, Kashmiri Lal, editor
- Published
- 1989
- Full Text
- View/download PDF
150. Implementation of Care Management: An Analysis of Recent AHRQ Research
- Author
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Andrada Tomoaia-Cotisel, Robert J. Reid, Janice Genevro, Erin L. McGinley, Michael K. Magill, Sanjeev N. Mehta, Diane Hauser, Leif I. Solberg, Michael D. Fetters, David Driscoll, Rachel L. Day, Christopher G. Wise, Jeanne W. McAllister, Ming Tai-Seale, Katrina E Donahue, Debra L. Scammon, Carolyn A. Berry, Jodi Summers Holtrop, Neil Calman, Timothy W. Farrell, Peter F. Cronholm, Michael I. Harrison, Hector P. Rodriguez, Cherie P. Brunker, and Robert A. Gabbay
- Subjects
Medical home ,Knowledge management ,care management ,Health literacy ,Article ,03 medical and health sciences ,primary care ,0302 clinical medicine ,Resource (project management) ,Social skills ,Nursing ,United States Agency for Healthcare Research and Quality ,Clinical Research ,Patient-Centered Care ,Health care ,Agency (sociology) ,Patient experience ,Medicine ,Humans ,030212 general & internal medicine ,implementation ,PCMH ,Data collection ,Primary Health Care ,business.industry ,030503 health policy & services ,Health Policy ,patient-centered medical home ,Business and Management ,Health Plan Implementation ,Health Services ,Continuity of Patient Care ,care coordination ,United States ,Good Health and Well Being ,Public Health and Health Services ,Health Policy & Services ,0305 other medical science ,business - Abstract
Care management (CM) is a promising team-based, patient-centered approach “designed to assist patients and their support systems in managing medical conditions more effectively.” As little is known about its implementation, this article describes CM implementation and associated lessons from 12 Agency for Healthcare Research and Quality–sponsored projects. Two rounds of data collection resulted in project-specific narratives that were analyzed using an iterative approach analogous to framework analysis. Informants also participated as coauthors. Variation emerged across practices and over time regarding CM services provided, personnel delivering these services, target populations, and setting(s). Successful implementation was characterized by resource availability (both monetary and nonmonetary), identifying as well as training employees with the right technical expertise and interpersonal skills, and embedding CM within practices. Our findings facilitate future context-specific implementation of CM within medical homes. They also inform the development of medical home recognition programs that anticipate and allow for contextual variation.
- Published
- 2016
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