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101. Test-Enhanced Life Cycle for Composed IoT-Based Services

Author

Kuemper, Daniel, Reetz, Eike Steffen, Hölker, Daniel, Tönjes, Ralf, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Bauschert, Thomas, editor

Published
2013
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104. Noise-induced swarming of active particles

Author

Ralf Toenjes and Chunming Zheng

Subjects
Soft Condensed Matter (cond-mat.soft), FOS: Physical sciences, Disordered Systems and Neural Networks (cond-mat.dis-nn), Condensed Matter - Soft Condensed Matter, Condensed Matter - Disordered Systems and Neural Networks
Abstract

We report on the effect of spatially correlated noise on the velocities of self propelled particles. Correlations in the random forces acting on self propelled particles can induce directed collective motion, i.e. swarming. Even with repulsive coupling in the velocity directions, which favors a disordered state, strong correlations in the fluctuations can align the velocities locally leading to a macroscopic, turbulent velocity field. On the other hand, while spatially correlated noise is aligning the velocities locally, the swarming transition to globally directed motion is inhibited when the correlation length of the noise is nonzero, but smaller than the system size. We analyze the swarming transition in $d$ dimensional space in a mean field model of globally coupled velocity vectors., Comment: 8 pages, 2 figures (9 panels), to appear in APS Physical Review E

Published
2022
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105. Effect of Caching in a Broker Based Context Provisioning System

Author

Liaquat Kiani, Saad, Knappmeyer, Michael, Reetz, Eike Steffen, Baker, Nigel, Tönjes, Ralf, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Lukowicz, Paul, editor, Kunze, Kai, editor, and Kortuem, Gerd, editor

Published
2010
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106. A Context Provisioning Framework to Support Pervasive and Ubiquitous Applications

Author

Knappmeyer, Michael, Baker, Nigel, Liaquat, Saad, Tönjes, Ralf, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Barnaghi, Payam, editor, Moessner, Klaus, editor, Presser, Mirko, editor, and Meissner, Stefan, editor

Published
2009
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109. Resources and Geographic Access to Care for Severe Pediatric Pneumonia in Four Resource-limited Settings

Author

Suzanne M. Simkovich, Lindsay J. Underhill, Miles A. Kirby, Mary E. Crocker, Dina Goodman, John P. McCracken, Lisa M. Thompson, Anaité Diaz-Artiga, Adly Castañaza-Gonzalez, Sarada S. Garg, Kalpana Balakrishnan, Gurusamy Thangavel, Ghislaine Rosa, Jennifer L. Peel, Thomas F. Clasen, Eric D. McCollum, William Checkley, Vigneswari Aravindalochanan, Dana B. Barr, Vanessa Burrowes, Devan Campbell, Eduardo Canuz, Howard Chang, Yunyun Chen, Marilú Chiang, Maggie L. Clark, Rachel Craik, Victor Dávila-Román, Lisa de las Fuentes, Oscar De Léon, Ephrem Dusabimana, Lisa Elon, Juan Gabriel Espinoza, Irma S. Pineda Fuentes, Savannah Gupton, Meghan Hardison, Stella Hartinger, Steven A. Harvey, Mayari Hengstermann, Phabiola Herrera, Shakir Hossen, Penelope Howards, Lindsay Jaacks, Shirin Jabbarzadeh, Michael A. Johnson, Abigail Jones, Katherine Kearns, Jacob Kremer, Margaret Laws, Patricia M. Lenzen, Jiawen Liao, Amy Lovvorn, Fiona Majorin, Julia McPeek, Rachel M. Meyers, J. Jaime Miranda, Erick Mollinedo, Lawrence Moulton, Krishnendu Mukhopadhyay, Luke Naeher, Abidan Nambajimana, Florien Ndagijimana, Azhar Nizam, Jean de Dieu Ntivuguruzwa, Aris Papageorghiou, Ricardo Piedrahita, Ajay Pillarisetti, Naveen Puttaswamy, Elisa Puzzolo, Ashlinn Quinn, Sarah Rajkumar, Usha Ramakrishnan, Davis Reardon, Joshua Rosenthal, P. Barry Ryan, Zoe Sakas, Sankar Sambandam, Jeremy Sarnat, Sheela Sinharoy, Kirk R. Smith, Kyle Steenland, Damien Swearing, Ashley K. Toenjes, Jean Damascene Uwizeyimana, Viviane Valdes, Amit Verma, Lance Waller, Megan Warnock, Kendra Williams, Wenlu Ye, and Bonnie Young

Subjects
Pulmonary and Respiratory Medicine, Referral, business.industry, Creative commons, Original Articles, low- and middle-income country, Critical Care and Intensive Care Medicine, medicine.disease, Environmental and Occupational Lung Disease/Pediatrics and Lung Development, pulse oximetry, health service accessibility, Pneumonia, Intervention (counseling), Health care, medicine, pneumonia, Humans, Medical emergency, Healthcare Disparities, business, Child, License, Limited resources, Cause of death
Abstract

RATIONALE: Pneumonia is the leading cause of death in children worldwide. Identifying and appropriately managing severe pneumonia in a timely manner improves outcomes. Little is known about the readiness of healthcare facilities to manage severe pediatric pneumonia in low-resource settings. OBJECTIVES: As part of the Household Air Pollution Intervention Network (HAPIN) trial, we sought to identify healthcare facilities that were adequately resourced to manage severe pediatric pneumonia in Jalapa, Guatemala (J-GUA); Puno, Peru (P-PER); Kayonza, Rwanda (K-RWA); and Tamil Nadu, India (T-IND). We conducted a facility-based survey of available infrastructure, staff, equipment, and medical consumables. Facilities were georeferenced and a road network analysis was performed. MEASUREMENTS AND MAIN RESULTS: Of the 350 healthcare facilities surveyed, 13% had adequate resources to manage severe pneumonia, 37% had pulse oximeters, and 44% had supplemental oxygen. Mean (±SD) travel time to an adequately-resourced facility was 41±19 minutes in J-GUA, 99±64 minutes in P-PER, 40±19 minutes in K-RWA, and 31±19 minutes in T-IND. Expanding pulse oximetry coverage to all facilities reduced travel time by 44% in J-GUA, 29% in P-PER, 29% in K-RWA, and 11% in T-IND (all p

Published
2021

114. Development and Utility of a PAK1-Selective Degrader

Author

Hoi-Yee Chow, Sofiia Karchugina, Brian J. Groendyke, Sean Toenjes, John Hatcher, Katherine A. Donovan, Eric S. Fischer, Gleb Abalakov, Bulat Faezov, Roland Dunbrack, Nathanael S. Gray, and Jonathan Chernoff

Subjects
Drug Discovery, Molecular Medicine, Article
Abstract

Amplification and/or overexpression of the PAK1 gene is common in several malignancies, and inhibition of PAK1 by small molecules has been shown to impede the growth and survival of such cells. Potent inhibitors of PAK1 and its close relatives, PAK2, and PAK3, have been described, but clinical development has been hindered by recent findings that PAK2 function is required for normal cardiovascular function in adult mice. A unique allosteric PAK1-selective inhibitor, NVS-PAK1-1, provides a potential path forward, but has relatively modest potency in cells. Here, we report the development of BJG-05-039, a PAK1-seletive degrader consisting of the allosteric PAK1 inhibitor NVS-PAK1-1 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). BJG-05-039 induced degradation of PAK1, but not PAK2, and displayed enhanced anti-proliferative effects relative to its parent compound in PAK1-dependent, but not PAK2-dependent, cell lines. Notably, BJG-05-039 promoted sustained PAK1 degradation and inhibition of downstream signaling effects at ten-fold lower dosage than NVS-PAK1-1. Our findings suggest that selective PAK1 degradation may confer more potent pharmacological effects compared with catalytic inhibition and highlight the potential advantages of PAK1-targeted degradation.

Published
2022

115. Leptin mediates protective effects on the vasculature

Author

V Filipova, P E Stuerzebecher, S Kralisch, M R Schubert, A Hoffmann, F Oliveira, B Sheikh, M Blueher, A Kogel, M Scholz, K Miehle, T Ebert, U Laufs, A Toenjes, and J N Boeckel

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Introduction and purpose Lipodystrophy (LD) syndromes are characterized by the loss of adipose tissue resulting in metabolic complications and accelerated atherosclerosis. The systemic concentration of the adipokine leptin is reduced in LD as a result of adipose tissue deficiency. A therapeutical option to treat LD is the substitution of leptin, which improves metabolic complications and reduces mortality. However, the vascular effects of leptin remain largely unknown. Here we analyze the direct effects of leptin on the vascular system and the development of atherosclerosis. Methods and results Treatment of human endothelial cells (ECs) with leptin reduced endothelial inflammation and the process of endothelial-to-mesenchymal transition (EndMT) (CNN1, −41.4%, p Cytokine screening revealed an increase of the growth differentiation factor 15 (GDF15) in serum of LD patients (+26.2%, p Conclusion Our findings indicate that EndMT is part of the cardiovascular disease progression in lipodystrophy syndromes. Leptin treatment has direct protective vascular effects by preventing inflammation, EndMT, and maintaining endothelial integrity. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)

Published
2022
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116. Effects of a liquefied petroleum gas cookstove and fuel intervention on preterm birth and gestational duration: the multi-country Household Air Pollution Intervention Network (HAPIN) trial

Author

Miles A. Kirby, Lisa Thompson, Ashley Toenjes, Aris Papageorghiou, Rachel Craik, Lisa Elon, Ashley Younger, Penelope P. Howards, Usha Ramakrishnan, John P. McCracken, Anaite Diaz-Artiga, Adly Castañaza-Gonzalez, Libny Monroy-Alarcon, Ghislaine Rose, Alexie Mukeshimana, Kalpana Balakrishnan, Sarada S. Garg, Lindsay J. Underhill, Michael Johnson, Ajay Pillarisetti, Ricardo Piedrahita, Joshua Rosenthal, Ashlinn Quinn, Lance Waller, Shirin Jabbarzadeh, Jiantong Wang, Kyle Steenland, Luke P. Naeher, Howard Chang, William Checkley, Thomas F. Clasen, and Jennifer L. Peel

Subjects
General Earth and Planetary Sciences, General Environmental Science
Published
2022
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119. Development and Utility of a PAK1-Selective Degrader

Author

Chow, Hoi-Yee, primary, Karchugina, Sofiia, additional, Groendyke, Brian J., additional, Toenjes, Sean, additional, Hatcher, John, additional, Donovan, Katherine A., additional, Fischer, Eric S., additional, Abalakov, Gleb, additional, Faezov, Bulat, additional, Dunbrack, Roland, additional, Gray, Nathanael S., additional, and Chernoff, Jonathan, additional

Published
2022
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121. Leptin mediates protective effects on the vasculature

Author

Filipova, V, primary, Stuerzebecher, P E, additional, Kralisch, S, additional, Schubert, M R, additional, Hoffmann, A, additional, Oliveira, F, additional, Sheikh, B, additional, Blueher, M, additional, Kogel, A, additional, Scholz, M, additional, Miehle, K, additional, Ebert, T, additional, Laufs, U, additional, Toenjes, A, additional, and Boeckel, J N, additional

Published
2022
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122. Effects of a liquefied petroleum gas cookstove and fuel intervention on preterm birth and gestational duration: the multi-country Household Air Pollution Intervention Network (HAPIN) trial

Author

Kirby, Miles A., primary, Thompson, Lisa, additional, Toenjes, Ashley, additional, Papageorghiou, Aris, additional, Craik, Rachel, additional, Elon, Lisa, additional, Younger, Ashley, additional, Howards, Penelope P., additional, Ramakrishnan, Usha, additional, McCracken, John P., additional, Diaz-Artiga, Anaite, additional, Castañaza-Gonzalez, Adly, additional, Monroy-Alarcon, Libny, additional, Rose, Ghislaine, additional, Mukeshimana, Alexie, additional, Balakrishnan, Kalpana, additional, Garg, Sarada S., additional, Underhill, Lindsay J., additional, Johnson, Michael, additional, Pillarisetti, Ajay, additional, Piedrahita, Ricardo, additional, Rosenthal, Joshua, additional, Quinn, Ashlinn, additional, Waller, Lance, additional, Jabbarzadeh, Shirin, additional, Wang, Jiantong, additional, Steenland, Kyle, additional, Naeher, Luke P., additional, Chang, Howard, additional, Checkley, William, additional, Clasen, Thomas F., additional, and Peel, Jennifer L., additional

Published
2022
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123. THOC5: a novel gene involved in HDL-cholesterol metabolism

Author

Keller, Maria, Schleinitz, Dorit, Förster, Julia, Tönjes, Anke, Böttcher, Yvonne, Fischer-Rosinsky, Antje, Breitfeld, Jana, Weidle, Kerstin, Rayner, Nigel W., Burkhardt, Ralph, Enigk, Beate, Müller, Ines, Halbritter, Jan, Koriath, Moritz, Pfeiffer, Andreas, Krohn, Knut, Groop, Leif, Spranger, Joachim, Stumvoll, Michael, and Kovacs, Peter

Published
2013
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124. Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics

Author

Berndt, Sonja I., Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tõnu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jian’an, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L., Neale, Benjamin M., Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L., Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E., König, Inke R., Kristiansson, Kati, Kutalik, Zoltán, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L., Medina-Gomez, Carolina, Müller-Nurasyid, Martina, Ngwa, Julius S., Nolte, Ilja M., Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J., Preuss, Michael, Rose, Lynda M., Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J., Surakka, Ida, Teumer, Alexander, Trip, Mieke D., Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V., Vandenput, Liesbeth, Waite, Lindsay L., Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W., Atalay, Mustafa, Attwood, Antony P., Balmforth, Anthony J., Basart, Hanneke, Beilby, John, Bonnycastle, Lori L., Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Connell, John M., Cookson, William, de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M., Farrall, Martin, Ferrario, Marco M., Ferrières, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V., Grallert, Harald, Grönberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S., Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L., Heath, Andrew C., Hebebrand, Johannes, Homuth, Georg, Hu, Frank B., Hunt, Sarah E., Hyppönen, Elina, Iribarren, Carlos, Jacobs, Kevin B., Jansson, John-Olov, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimaki, Mika, Koenig, Wolfgang, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H., Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A., Magnusson, Patrik K., Manunta, Paolo, Marek, Diana, März, Winfried, Leach, Irene Mateo, McKnight, Barbara, Medland, Sarah E., Mihailov, Evelin, Milani, Lili, Montgomery, Grant W., Mooser, Vincent, Mühleisen, Thomas W., Munroe, Patricia B., Musk, Arthur W., Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A., Ong, Ken K., Oostra, Ben A., Palmer, Colin N.A., Palotie, Aarno, Peden, John F., Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Prokopenko, Inga, Pütter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E., Sambrook, Jennifer G., Sanders, Alan R., Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stančáková, Alena, Stark, Klaus, Stephens, Jonathan C., Stirrups, Kathleen, Stolk, Ronald P., Stumvoll, Michael, Swift, Amy J., Theodoraki, Eirini V., Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M., van Meurs, Joyce B.J., Vermeulen, Sita H., Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gérard, Wang, Zhaoming, Widén, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Winkelmann, Bernhard R., Witteman, Jacqueline C.M., Wolffenbuttel, Bruce H.R., Wong, Andrew, Wright, Alan F., Zillikens, M. Carola, Amouyel, Philippe, Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Cupples, L. Adrienne, Cusi, Daniele, Dedoussis, George V., Erdmann, Jeanette, Eriksson, Johan G., Franks, Paul W., Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hengstenberg, Christian, Hicks, Andrew A., Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Levinson, Douglas F., Martin, Nicholas G., Metspalu, Andres, Morris, Andrew D., Nieminen, Markku S., Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Ouwehand, Willem H., Palmer, Lyle J., Penninx, Brenda, Power, Chris, Province, Michael A., Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Ridker, Paul M., Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J., Snieder, Harold, Sørensen, Thorkild I.A., Spector, Timothy D., Stefansson, Kari, Tönjes, Anke, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H.-Erich, Wilson, James F., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Inês, Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Frayling, Timothy, Groop, Leif C., Haritunian, Talin, Heid, Iris M., Hunter, David, Kaplan, Robert C., Karpe, Fredrik, Moffatt, Miriam, Mohlke, Karen L., O’Connell, Jeffrey R., Pawitan, Yudi, Schadt, Eric E., Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P., Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Visscher, Peter M., Di Blasio, Anna Maria, Hirschhorn, Joel N., Lindgren, Cecilia M., Morris, Andrew P., Meyre, David, Scherag, André, McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Loos, Ruth J.F., Ingelsson, Erik, and Hirschhorn, Joel

Published
2013
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126. Preface

Author

Carlson, Kristin, Jochum, Elizabeth, Rajko, Jessica, Dahl, Luke, Corness, Greg, Imus, Susan, and Toenjes, John

Published
2022
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127. Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

Author

Sturm, Dominik, Witt, Hendrik, Hovestadt, Volker, Khuong-Quang, Dong-Anh, Jones, David T.W., Konermann, Carolin, Pfaff, Elke, Tönjes, Martje, Sill, Martin, Bender, Sebastian, Kool, Marcel, Zapatka, Marc, Becker, Natalia, Zucknick, Manuela, Hielscher, Thomas, Liu, Xiao-Yang, Fontebasso, Adam M., Ryzhova, Marina, Albrecht, Steffen, Jacob, Karine, Wolter, Marietta, Ebinger, Martin, Schuhmann, Martin U., van Meter, Timothy, Frühwald, Michael C., Hauch, Holger, Pekrun, Arnulf, Radlwimmer, Bernhard, Niehues, Tim, von Komorowski, Gregor, Dürken, Matthias, Kulozik, Andreas E., Madden, Jenny, Donson, Andrew, Foreman, Nicholas K., Drissi, Rachid, Fouladi, Maryam, Scheurlen, Wolfram, von Deimling, Andreas, Monoranu, Camelia, Roggendorf, Wolfgang, Herold-Mende, Christel, Unterberg, Andreas, Kramm, Christof M., Felsberg, Jörg, Hartmann, Christian, Wiestler, Benedikt, Wick, Wolfgang, Milde, Till, Witt, Olaf, Lindroth, Anders M., Schwartzentruber, Jeremy, Faury, Damien, Fleming, Adam, Zakrzewska, Magdalena, Liberski, Pawel P., Zakrzewski, Krzysztof, Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Morrissy, Sorana, Cavalli, Florence, Taylor, Michael D., van Sluis, Peter, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, Mikkelsen, Tom, Aldape, Kenneth, Reifenberger, Guido, Collins, V. Peter, Majewski, Jacek, Korshunov, Andrey, Lichter, Peter, Plass, Christoph, Jabado, Nada, and Pfister, Stefan M.

Published
2012
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128. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Author

Schumann, Gunter, Coin, Lachlan J., Lourdusamy, Anbarasu, Charoen, Pimphen, Berger, Karen H., Stacey, David, Desrivières, Sylvane, Aliev, Fazil A., Khan, Anokhi A., Amin, Najaf, Aulchenko, Yurii S., Bakalkin, Georgy, Bakker, Stephan J., Balkau, Beverley, Beulens, Joline W., Bilbao, Ainhoa, de Boer, Rudolf A., Beury, Delphine, Bots, Michiel L., Breetvelt, Elemi J., Cauchi, Stéphane, Cavalcanti-Proença, Christine, Chambers, John C., Clarke, Toni-Kim, Dahmen, Norbert, de Geus, Eco J., Dick, Danielle, Ducci, Francesca, Easton, Alanna, Edenberg, Howard J., Esk, Tõnu, Fernández-Medarde, Alberto, Foroud, Tatiana, Freimer, Nelson B., Girault, Jean-Antoine, Grobbee, Diederick E., Guarrera, Simonetta, Gudbjartsson, Daniel F., Hartikainen, Anna-Liisa, Heath, Andrew C., Hesselbrock, Victor, Hofman, Albert, Hottenga, Jouke-Jan, Isohanni, Matti K., Kaprio, Jaakko, Khaw, Kay-Tee, Kuehnel, Brigitte, Laitinen, Jaana, Lobbens, Stéphane, Luan, Jian'an, Mangino, Massimo, Maroteaux, Matthieu, Matullo, Giuseppe, McCarthy, Mark I., Mueller, Christian, Navis, Gerjan, Numans, Mattijs E., Núñez, Alejandro, Nyholt, Dale R., Onland-Moret, Charlotte N., Oostra, Ben A., O'Reilly, Paul F., Palkovits, Miklos, Penninx, Brenda W., Polidoro, Silvia, Pouta, Anneli, Prokopenko, Inga, Ricceri, Fulvio, Santos, Eugenio, Smit, Johannes H., Soranzo, Nicole, Song, Kijoung, Sovio, Ulla, Stumvoll, Michael, Surakk, Ida, Thorgeirsson, Thorgeir E., Thorsteinsdottir, Unnur, Troakes, Claire, Tyrfingsson, Thorarinn, Tönjes, Anke, Uiterwaal, Cuno S., Uitterlinden, Andre G., van der Harst, Pim, van der Schouw, Yvonne T., Staehlin, Oliver, Vogelzangs, Nicole, Vollenweider, Peter, Waeber, Gerard, Wareham, Nicholas J., Waterworth, Dawn M., Whitfield, John B., Wichmann, Erich H., Willemsen, Gonneke, Witteman, Jacqueline C., Yuan, Xin, Zhai, Guangju, Zhao, Jing H., Zhang, Weihua, Martin, Nicholas G., Metspalu, Andres, Doering, Angela, Scott, James, Spector, Tim D., Loos, Ruth J., Boomsma, Dorret I., Mooser, Vincent, Peltonen, Leena, Stefansson, Kari, van Duijn, Cornelia M., Vineis, Paolo, Sommer, Wolfgang H., Kooner, Jaspal S., Spanagel, Rainer, Heberlein, Ulrike A., Jarvelin, Marjo-Riitta, Elliott, Paul, and Singer, Burton H.

Published
2011

129. Redox-Responsive H-Bonding: Amplifying the Effect of Electron Transfer Using Proton-Coupled Electron Transfer

Author

Sean T. Toenjes, Kiyeol Baek, Jeffrey L. Gustafson, Diane K. Smith, and Hyejeong Choi

Subjects
Proton, Hydrogen bond, Chemistry, Ionic bonding, General Chemistry, 010402 general chemistry, Redox responsive, 01 natural sciences, Biochemistry, Catalysis, 0104 chemical sciences, Electron transfer, Crystallography, Colloid and Surface Chemistry, Nmr titration, Proton-coupled electron transfer, Cyclic voltammetry
Abstract

A new strategy to create highly redox-responsive H-bond dimers based on proton-coupled electron transfer is proposed that capitalizes on the importance of secondary H-bonds in determining overall binding strength in H-bond dimers. Electron transfer induced proton transfer across a H-bond can be used to significantly strengthen the overall binding by both creating strong ionic H-bonds and changing the secondary H-bonds from unfavorable to favorable. The viability and potency of this approach are demonstrated with an electroactive DAD (A = H-acceptor, D = H-donor) array, H(MQ+)H, paired with an electroinactive ADA array, O(NH)O. NMR titration of H(MQ+)H with O(NH)O in 0.1 M NBu4PF6/CD2Cl2 gives a Kassoc of 500 M-1, typical of DAD-ADA dimers. However, upon two-electron reduction in 0.1 M NBu4PF6/CH2Cl2, cyclic voltammetry studies indicate a 1.8 × 105 increase in binding strength, corresponding to a very large Kassoc of 9 × 107 M-1. The latter value is typical of DDD-AAA H-bond dimers, consistent with proton transfer across the central H-bond upon reduction.

Published
2020
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130. Grade Retention and Social Promotion in Texas, 1994-99: Academic Achievement among Elementary School Students

Author

Lorence, Jon, Dworkin, Anthony Gary, Toenjes, Laurence A., and Hill, Antwanette N.

Abstract

Although considerable research examines the impact of grade retention on student academic achievement, various shortcomings exhibited across these studies make it difficult to derive any concrete generalizations about the effectiveness of requiring students to repeat a grade. By utilizing data based on a cohort of all low-achieving elementary students in the state of Texas over a number of years, one can overcome some of the weaknesses observed in previous studies on grade retention and social promotion. The purpose of this study is to ascertain whether holding low-achieving students back a year in grade contributes to enhancing academic performance. This analysis is based upon archival data supplied by the Texas Education Agency, consisting of anonymous student-level Texas Assessment of Academic Skills (TAAS) records of every student in the tested grades between 1994 and 1999. The authors sought to determine the academic effects of retention in grade and social promotion on subsequent school performances, following initial failure on the Texas mandatory standardized reading test. The overall findings suggest that retaining low-performing third-grade students an additional year in grade was not harmful to their later academic performance. Analyses that attempted to control for initial differences between retained and socially promoted pupils revealed that retention appeared to help low-achieving students pass the state reading examination more quickly than students who were socially promoted. The authors conclude by outlining some conditions that they argue are essential for effective policy, effective interventions, and disaggregated accountability systems. Comments by Andrew Rotherham and Lorrie A. Shepard are presented. (Contains 1 figure, 8 tables, 52 notes.)

Published
2002
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131. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Author

Winkler, Thomas W., Rasheed, Humaira, Teumer, Alexander, Gorski, Mathias, Rowan, Bryce X., Stanzick, Kira J., Thomas, Laurent F., Tin, Adrienne, Hoppmann, Anselm, Chu, Audrey Y., Tayo, Bamidele, Thio, Chris H. L., Cusi, Daniele, Chai, Jin-Fang, Sieber, Karsten B., Horn, Katrin, Li, Man, Scholz, Markus, Cocca, Massimiliano, Wuttke, Matthias, van der Most, Peter J., Yang, Qiong, Ghasemi, Sahar, Nutile, Teresa, Li, Yong, Pontali, Giulia, Guenther, Felix, Dehghan, Abbas, Correa, Adolfo, Parsa, Afshin, Feresin, Agnese, de Vries, Aiko P. J., Zonderman, Alan B., Smith, Albert, V, Oldehinkel, Albertine J., De Grandi, Alessandro, Rosenkranz, Alexander R., Franke, Andre, Teren, Andrej, Metspalu, Andres, Hicks, Andrew A., Morris, Andrew P., Toenjes, Anke, Morgan, Anna, Podgornaia, Anna, I, Peters, Annette, Koerner, Antje, Mahajan, Anubha, Campbell, Archie, Freedman, Barry, I, Spedicati, Beatrice, Ponte, Belen, Schoettker, Ben, Brumpton, Ben, Banas, Bernhard, Kraemer, Bernhard K., Jung, Bettina, Asvold, Bjorn Olav, Smith, Blair H., Ning, Boting, Penninx, Brenda W. J. H., Vanderwerff, Brett R., Psaty, Bruce M., Kammerer, Candace M., Langefeld, Carl D., Hayward, Caroline, Spracklen, Cassandra N., Robinson-Cohen, Cassianne, Hartman, Catharina A., Lindgren, Cecilia M., Wang, Chaolong, Sabanayagam, Charumathi, Heng, Chew-Kiat, Lanzani, Chiara, Khor, Chiea-Chuen, Cheng, Ching-Yu, Fuchsberger, Christian, Gieger, Christian, Shaffer, Christian M., Schulz, Christina-Alexandra, Willer, Cristen J., Chasman, Daniel, I, Gudbjartsson, Daniel F., Ruggiero, Daniela, Toniolo, Daniela, Czamara, Darina, Porteous, David J., Waterworth, Dawn M., Mascalzoni, Deborah, Mook-Kanamori, Dennis O., Reilly, Dermot F., Daw, E. Warwick, Hofer, Edith, Boerwinkle, Eric, Salvi, Erika, Bottinger, Erwin P., Tai, E-Shyong, Catamo, Eulalia, Rizzi, Federica, Guo, Feng, Rivadeneira, Fernando, Guilianini, Franco, Sveinbjornsson, Gardar, Ehret, Georg, Waeber, Gerard, Biino, Ginevra, Girotto, Giorgia, Pistis, Giorgio, Nadkarni, Girish N., Delgado, Graciela E., Montgomery, Grant W., Snieder, Harold, Campbell, Harry, White, Harvey D., Gao, He, Stringham, Heather M., Schmidt, Helena, Li, Hengtong, Brenner, Hermann, Holm, Hilma, Kirsten, Holgen, Kramer, Holly, Rudan, Igor, Nolte, Ilja M., Tzoulaki, Ioanna, Olafsson, Isleifur, Martins, Jade, Cook, James P., Wilson, James F., Halbritter, Jan, Felix, Janine F., Divers, Jasmin, Kooner, Jaspal S., Lee, Jeannette Jen-Mai, O'Connell, Jeffrey, Rotter, Jerome, I, Liu, Jianjun, Xu, Jie, Thiery, Joachim, Ärnlöv, Johan, Kuusisto, Johanna, Jakobsdottir, Johanna, Tremblay, Johanne, Chambers, John C., Whitfield, John B., Gaziano, John M., Marten, Jonathan, Coresh, Josef, Jonas, Jost B., Mychaleckyj, Josyf C., Christensen, Kaare, Eckardt, Kai-Uwe, Mohlke, Karen L., Endlich, Karlhans, Dittrich, Katalin, Ryan, Kathleen A., Rice, Kenneth M., Taylor, Kent D., Ho, Kevin, Nikus, Kjell, Matsuda, Koichi, Strauch, Konstantin, Miliku, Kozeta, Hveem, Kristian, Lind, Lars, Wallentin, Lars, Yerges-Armstrong, Laura M., Raffield, Laura M., Phillips, Lawrence S., Launer, Lenore J., Lyytikainen, Leo-Pekka, Lange, Leslie A., Citterio, Lorena, Klaric, Lucija, Ikram, M. Arfan, Ising, Marcus, Kleber, Marcus E., Francescatto, Margherita, Concas, Maria Pina, Ciullo, Marina, Piratsu, Mario, Orho-Melander, Marju, Laakso, Markku, Loeffler, Markus, Perola, Markus, de Borst, Martin H., Gogele, Martin, La Bianca, Martina, Lukas, Mary Ann, Feitosa, Mary F., Biggs, Mary L., Wojczynski, Mary K., Kavousi, Maryam, Kanai, Masahiro, Akiyama, Masato, Yasuda, Masayuki, Nauck, Matthias, Waldenberger, Melanie, Chee, Miao-Li, Chee, Miao-Ling, Boehnke, Michael, Preuss, Michael H., Stumvoll, Michael, Province, Michael A., Evans, Michele K., O'Donoghue, Michelle L., Kubo, Michiaki, Kahonen, Mika, Kastarinen, Mika, Nalls, Mike A., Kuokkanen, Mikko, Ghanbari, Mohsen, Bochud, Murielle, Josyula, Navya Shilpa, Martin, Nicholas G., Tan, Nicholas Y. Q., Palmer, Nicholette D., Pirastu, Nicola, Schupf, Nicole, Verweij, Niek, Hutri-Kahonen, Nina, Mononen, Nina, Bansal, Nisha, Devuyst, Olivier, Melander, Olle, Raitakari, Olli T., Polasek, Ozren, Manunta, Paolo, Gasparini, Paolo, Mishra, Pashupati P., Sulem, Patrick, Magnusson, Patrik K. E., Elliott, Paul, Ridker, Paul M., Hamet, Pavel, Svensson, Per O., Joshi, Peter K., Kovacs, Peter, Pramstaller, Peter P., Rossing, Peter, Vollenweider, Peter, van der Harst, Pim, Dorajoo, Rajkumar, Sim, Ralene Z. H., Burkhardt, Ralph, Tao, Ran, Noordam, Raymond, Magi, Reedik, Schmidt, Reinhold, de Mutsert, Renee, Rueedi, Rico, van Dam, Rob M., Carroll, Robert J., Gansevoort, Ron T., Loos, Ruth J. F., Felicita, Sala Cinzia, Sedaghat, Sanaz, Padmanabhan, Sandosh, Freitag-Wolf, Sandra, Pendergrass, Sarah A., Graham, Sarah E., Gordon, Scott D., Hwang, Shih-Jen, Kerr, Shona M., Vaccargiu, Simona, Patil, Snehal B., Hallan, Stein, Bakker, Stephan J. L., Lim, Su-Chi, Lucae, Susanne, Vogelezang, Suzanne, Bergmann, Sven, Corre, Tanguy, Ahluwalia, Tarunveer S., Lehtimaki, Terho, Boutin, Thibaud S., Meitinger, Thomas, Wong, Tien-Yin, Bergler, Tobias, Rabelink, Ton J., Esko, Tonu, Haller, Toomas, Thorsteinsdottir, Unnur, Voelker, Uwe, Foo, Valencia Hui Xian, Salomaa, Veikko, Vitart, Veronique, Giedraitis, Vilmantas, Gudnason, Vilmundur, Jaddoe, Vincent W. V., Huang, Wei, Zhang, Weihua, Wei, Wen Bin, Kiess, Wieland, Marz, Winfried, Koenig, Wolfgang, Lieb, Wolfgang, Gao, Xin, Sim, Xueling, Wang, Ya Xing, Friedlander, Yechiel, Tham, Yih-Chung, Kamatani, Yoichiro, Okada, Yukinori, Milaneschi, Yuri, Yu, Zhi, Stark, Klaus J., Stefansson, Kari, Boeger, Carsten A., Hung, Adriana M., Kronenberg, Florian, Koettgen, Anna, Pattaro, Cristian, Heid, Iris M., Winkler, Thomas W., Rasheed, Humaira, Teumer, Alexander, Gorski, Mathias, Rowan, Bryce X., Stanzick, Kira J., Thomas, Laurent F., Tin, Adrienne, Hoppmann, Anselm, Chu, Audrey Y., Tayo, Bamidele, Thio, Chris H. L., Cusi, Daniele, Chai, Jin-Fang, Sieber, Karsten B., Horn, Katrin, Li, Man, Scholz, Markus, Cocca, Massimiliano, Wuttke, Matthias, van der Most, Peter J., Yang, Qiong, Ghasemi, Sahar, Nutile, Teresa, Li, Yong, Pontali, Giulia, Guenther, Felix, Dehghan, Abbas, Correa, Adolfo, Parsa, Afshin, Feresin, Agnese, de Vries, Aiko P. J., Zonderman, Alan B., Smith, Albert, V, Oldehinkel, Albertine J., De Grandi, Alessandro, Rosenkranz, Alexander R., Franke, Andre, Teren, Andrej, Metspalu, Andres, Hicks, Andrew A., Morris, Andrew P., Toenjes, Anke, Morgan, Anna, Podgornaia, Anna, I, Peters, Annette, Koerner, Antje, Mahajan, Anubha, Campbell, Archie, Freedman, Barry, I, Spedicati, Beatrice, Ponte, Belen, Schoettker, Ben, Brumpton, Ben, Banas, Bernhard, Kraemer, Bernhard K., Jung, Bettina, Asvold, Bjorn Olav, Smith, Blair H., Ning, Boting, Penninx, Brenda W. J. H., Vanderwerff, Brett R., Psaty, Bruce M., Kammerer, Candace M., Langefeld, Carl D., Hayward, Caroline, Spracklen, Cassandra N., Robinson-Cohen, Cassianne, Hartman, Catharina A., Lindgren, Cecilia M., Wang, Chaolong, Sabanayagam, Charumathi, Heng, Chew-Kiat, Lanzani, Chiara, Khor, Chiea-Chuen, Cheng, Ching-Yu, Fuchsberger, Christian, Gieger, Christian, Shaffer, Christian M., Schulz, Christina-Alexandra, Willer, Cristen J., Chasman, Daniel, I, Gudbjartsson, Daniel F., Ruggiero, Daniela, Toniolo, Daniela, Czamara, Darina, Porteous, David J., Waterworth, Dawn M., Mascalzoni, Deborah, Mook-Kanamori, Dennis O., Reilly, Dermot F., Daw, E. Warwick, Hofer, Edith, Boerwinkle, Eric, Salvi, Erika, Bottinger, Erwin P., Tai, E-Shyong, Catamo, Eulalia, Rizzi, Federica, Guo, Feng, Rivadeneira, Fernando, Guilianini, Franco, Sveinbjornsson, Gardar, Ehret, Georg, Waeber, Gerard, Biino, Ginevra, Girotto, Giorgia, Pistis, Giorgio, Nadkarni, Girish N., Delgado, Graciela E., Montgomery, Grant W., Snieder, Harold, Campbell, Harry, White, Harvey D., Gao, He, Stringham, Heather M., Schmidt, Helena, Li, Hengtong, Brenner, Hermann, Holm, Hilma, Kirsten, Holgen, Kramer, Holly, Rudan, Igor, Nolte, Ilja M., Tzoulaki, Ioanna, Olafsson, Isleifur, Martins, Jade, Cook, James P., Wilson, James F., Halbritter, Jan, Felix, Janine F., Divers, Jasmin, Kooner, Jaspal S., Lee, Jeannette Jen-Mai, O'Connell, Jeffrey, Rotter, Jerome, I, Liu, Jianjun, Xu, Jie, Thiery, Joachim, Ärnlöv, Johan, Kuusisto, Johanna, Jakobsdottir, Johanna, Tremblay, Johanne, Chambers, John C., Whitfield, John B., Gaziano, John M., Marten, Jonathan, Coresh, Josef, Jonas, Jost B., Mychaleckyj, Josyf C., Christensen, Kaare, Eckardt, Kai-Uwe, Mohlke, Karen L., Endlich, Karlhans, Dittrich, Katalin, Ryan, Kathleen A., Rice, Kenneth M., Taylor, Kent D., Ho, Kevin, Nikus, Kjell, Matsuda, Koichi, Strauch, Konstantin, Miliku, Kozeta, Hveem, Kristian, Lind, Lars, Wallentin, Lars, Yerges-Armstrong, Laura M., Raffield, Laura M., Phillips, Lawrence S., Launer, Lenore J., Lyytikainen, Leo-Pekka, Lange, Leslie A., Citterio, Lorena, Klaric, Lucija, Ikram, M. Arfan, Ising, Marcus, Kleber, Marcus E., Francescatto, Margherita, Concas, Maria Pina, Ciullo, Marina, Piratsu, Mario, Orho-Melander, Marju, Laakso, Markku, Loeffler, Markus, Perola, Markus, de Borst, Martin H., Gogele, Martin, La Bianca, Martina, Lukas, Mary Ann, Feitosa, Mary F., Biggs, Mary L., Wojczynski, Mary K., Kavousi, Maryam, Kanai, Masahiro, Akiyama, Masato, Yasuda, Masayuki, Nauck, Matthias, Waldenberger, Melanie, Chee, Miao-Li, Chee, Miao-Ling, Boehnke, Michael, Preuss, Michael H., Stumvoll, Michael, Province, Michael A., Evans, Michele K., O'Donoghue, Michelle L., Kubo, Michiaki, Kahonen, Mika, Kastarinen, Mika, Nalls, Mike A., Kuokkanen, Mikko, Ghanbari, Mohsen, Bochud, Murielle, Josyula, Navya Shilpa, Martin, Nicholas G., Tan, Nicholas Y. Q., Palmer, Nicholette D., Pirastu, Nicola, Schupf, Nicole, Verweij, Niek, Hutri-Kahonen, Nina, Mononen, Nina, Bansal, Nisha, Devuyst, Olivier, Melander, Olle, Raitakari, Olli T., Polasek, Ozren, Manunta, Paolo, Gasparini, Paolo, Mishra, Pashupati P., Sulem, Patrick, Magnusson, Patrik K. E., Elliott, Paul, Ridker, Paul M., Hamet, Pavel, Svensson, Per O., Joshi, Peter K., Kovacs, Peter, Pramstaller, Peter P., Rossing, Peter, Vollenweider, Peter, van der Harst, Pim, Dorajoo, Rajkumar, Sim, Ralene Z. H., Burkhardt, Ralph, Tao, Ran, Noordam, Raymond, Magi, Reedik, Schmidt, Reinhold, de Mutsert, Renee, Rueedi, Rico, van Dam, Rob M., Carroll, Robert J., Gansevoort, Ron T., Loos, Ruth J. F., Felicita, Sala Cinzia, Sedaghat, Sanaz, Padmanabhan, Sandosh, Freitag-Wolf, Sandra, Pendergrass, Sarah A., Graham, Sarah E., Gordon, Scott D., Hwang, Shih-Jen, Kerr, Shona M., Vaccargiu, Simona, Patil, Snehal B., Hallan, Stein, Bakker, Stephan J. L., Lim, Su-Chi, Lucae, Susanne, Vogelezang, Suzanne, Bergmann, Sven, Corre, Tanguy, Ahluwalia, Tarunveer S., Lehtimaki, Terho, Boutin, Thibaud S., Meitinger, Thomas, Wong, Tien-Yin, Bergler, Tobias, Rabelink, Ton J., Esko, Tonu, Haller, Toomas, Thorsteinsdottir, Unnur, Voelker, Uwe, Foo, Valencia Hui Xian, Salomaa, Veikko, Vitart, Veronique, Giedraitis, Vilmantas, Gudnason, Vilmundur, Jaddoe, Vincent W. V., Huang, Wei, Zhang, Weihua, Wei, Wen Bin, Kiess, Wieland, Marz, Winfried, Koenig, Wolfgang, Lieb, Wolfgang, Gao, Xin, Sim, Xueling, Wang, Ya Xing, Friedlander, Yechiel, Tham, Yih-Chung, Kamatani, Yoichiro, Okada, Yukinori, Milaneschi, Yuri, Yu, Zhi, Stark, Klaus J., Stefansson, Kari, Boeger, Carsten A., Hung, Adriana M., Kronenberg, Florian, Koettgen, Anna, Pattaro, Cristian, and Heid, Iris M.

Abstract

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease. Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

Published
2022
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137. GHFutures2030 Youth Statement + Call for Action

Author

Wong, Brian Li Han, Gray, Whitney, Stevens, Enow Awah Georges, Ali, Mohamed El Amine Youcef, Galban, Dexter, Hasse, Alexa, Siepmann, Ines, Tandon, Sahil, Acosta-Gómez, Jaime, Ainomugisha, Martha, Azelmat, Marwa, Benslimane, Yasmina, Bewa, Joannie Marlene, Blom, Iris Martine, Retana, Francisca Milena Chacón, Chiu, Yi-Chi, Clausin, Mia, Fagan, Lucy, Francis, Toluse Dove, Iyere, Jordan, Janušonytė, Eglė, Kalmus-Eliasz, Michael, Madadi, Oussama, Mahesh, Rewena, Messerli, Natalie, Mgogwe, Dorcasbahati, Monley, Vanessa, Mullings, Danielle, Murgor, Mellany, Neumann, Micaela, Peace-Angel, Yinkore, Radyk, Rachel Elizabeth, Pujiani, Florensia Rahati, Toenjes, Ralf, and Yi, Whitley

Abstract

For the first time, a joint The Lancet and Financial Times Commission on Governing health futures2030: Growing up in a digital world (hereafter: GHFutures2030, or the Commission) is exploring the convergence of digital health, artificial intelligence (AI), and universal health coverage (UHC) with a focus on improving and safeguarding the health and wellbeing of children and young people. Digital and data tools and technologies are fundamentally changing approaches to health and the design of health systems – but governance models have not yet followed the pace of innovation. Striving for integrated digital development that improves the health and wellbeing of children and young people in an ever more digital world, the objective of the Commission is to deliver a clear set of recommendations on the governance of digital health taking full account of geopolitical, economic, and social factors. The Commission brings together independent Commissioners from a range of sectors and disciplines to deliver a final report scheduled for late 2021. For children and young people (hereafter: youth) to truly have agency with respect to digital technologies and approaches for which they are the intended end users or beneficiaries, they need to be enfranchised and empowered to participate – beyond just being loosely engaged – in every step of the process. The meaningful enfranchisement of youth is a central tenet of the Commission’s work. GHFutures2030 strives to ensure that digital health (DH) governance is codesigned and co-governed for and with youth to drive forward the agenda of achieving desired health futures for all. Thirty-five participants representing twenty-three global youth networks participated in a two-part GHFutures2030 Youth Consultation, titled “What do youth want to see in the future of health governance?”. The aims of the consultation were threefold: first, to hear from youth as to how they identify as a group; second, to understand their main concerns and proposed solutions with respect to the digital transformations in health; and third, provide space for Commissioners to hear from youth on the health futures they they want.

Published
2022
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138. Numerical Modelling of In-Situ Alloying of Al and Cu Using the Laser Powder Bed Fusion Process: A Study on the Effect of Energy Density and Remelting on Deposited Track Homogeneity

Author

Arvind Chouhan, Marcel Hesselmann, Anastasiya Toenjes, Lutz Mädler, and Nils Ellendt

Subjects
History, Polymers and Plastics, Biomedical Engineering, General Materials Science, Business and International Management, Engineering (miscellaneous), Industrial and Manufacturing Engineering
Published
2022
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141. Using an Indirect Measure of School District Wealth To Calculate Wealth Neutrality Indexes.

Author

Toenjes, Laurence A.

Abstract

Uses Texas data to explore using an indirect measure of local wealth as the basis for calculating indexes of wealth neutrality. The proposed measure, the percentage of school district revenues derived from local sources, can easily be calculated from data contained within the U.S. Department of Education's Common Core of Data. The measure facilitates annual, comprehensive comparisons of wealth neutrality across all states. (MLH)

Published
1997

145. Resources and Geographic Access to Care for Severe Pediatric Pneumonia in Four Resource-limited Settings

Author

Simkovich, Suzanne M., primary, Underhill, Lindsay J., additional, Kirby, Miles A., additional, Crocker, Mary E., additional, Goodman, Dina, additional, McCracken, John P., additional, Thompson, Lisa M., additional, Diaz-Artiga, Anaité, additional, Castañaza-Gonzalez, Adly, additional, Garg, Sarada S., additional, Balakrishnan, Kalpana, additional, Thangavel, Gurusamy, additional, Rosa, Ghislaine, additional, Peel, Jennifer L., additional, Clasen, Thomas F., additional, McCollum, Eric D., additional, Checkley, William, additional, Aravindalochanan, Vigneswari, additional, Barr, Dana B., additional, Burrowes, Vanessa, additional, Campbell, Devan, additional, Canuz, Eduardo, additional, Chang, Howard, additional, Chen, Yunyun, additional, Chiang, Marilú, additional, Clark, Maggie L., additional, Craik, Rachel, additional, Dávila-Román, Victor, additional, Fuentes, Lisa de las, additional, Léon, Oscar De, additional, Dusabimana, Ephrem, additional, Elon, Lisa, additional, Espinoza, Juan Gabriel, additional, Fuentes, Irma S. Pineda, additional, Gupton, Savannah, additional, Hardison, Meghan, additional, Hartinger, Stella, additional, Harvey, Steven A., additional, Hengstermann, Mayari, additional, Herrera, Phabiola, additional, Hossen, Shakir, additional, Howards, Penelope, additional, Jaacks, Lindsay, additional, Jabbarzadeh, Shirin, additional, Johnson, Michael A., additional, Jones, Abigail, additional, Kearns, Katherine, additional, Kremer, Jacob, additional, Laws, Margaret, additional, Lenzen, Patricia M., additional, Liao, Jiawen, additional, Lovvorn, Amy, additional, Majorin, Fiona, additional, McPeek, Julia, additional, Meyers, Rachel M., additional, Miranda, J. Jaime, additional, Mollinedo, Erick, additional, Moulton, Lawrence, additional, Mukhopadhyay, Krishnendu, additional, Naeher, Luke, additional, Nambajimana, Abidan, additional, Ndagijimana, Florien, additional, Nizam, Azhar, additional, Ntivuguruzwa, Jean de Dieu, additional, Papageorghiou, Aris, additional, Piedrahita, Ricardo, additional, Pillarisetti, Ajay, additional, Puttaswamy, Naveen, additional, Puzzolo, Elisa, additional, Quinn, Ashlinn, additional, Rajkumar, Sarah, additional, Ramakrishnan, Usha, additional, Reardon, Davis, additional, Rosenthal, Joshua, additional, Ryan, P. Barry, additional, Sakas, Zoe, additional, Sambandam, Sankar, additional, Sarnat, Jeremy, additional, Sinharoy, Sheela, additional, Smith, Kirk R., additional, Steenland, Kyle, additional, Swearing, Damien, additional, Toenjes, Ashley K., additional, Uwizeyimana, Jean Damascene, additional, Valdes, Viviane, additional, Verma, Amit, additional, Waller, Lance, additional, Warnock, Megan, additional, Williams, Kendra, additional, Ye, Wenlu, additional, and Young, Bonnie, additional

Published
2022
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147. Human blood DNA methylation patterns reflect individual lifestyle

Author

Klemp, Ireen, primary, Hoffmann, Anne, additional, Mueller, Luise, additional, Hagemann, Tobias, additional, Horn, Kathrin, additional, Rohde-Zimmerman, Kerstin, additional, Toenjes, Anke, additional, Thiery, Joachim, additional, Loeffler, Markus, additional, Burkhardt, Ralph, additional, Boettcher, Yvonne, additional, Stumvoll, Michael, additional, Blueher, Matthias, additional, Krohn, Knut, additional, Scholz, Markus, additional, Baber, Ronny, additional, Franks, Paul W, additional, Kovacs, Peter, additional, and Keller, Maria, additional

Published
2021
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148. Pharmacists as Personalized Medicine Experts (PRIME): Experiences Implementing Pharmacist-Led Pharmacogenomic Testing in Primary Care Practices

Author

Luke, Miles J., primary, Krupetsky, Nina, additional, Liu, Helen, additional, Korenvain, Clara, additional, Crown, Natalie, additional, Toenjes, Sameera, additional, Sproule, Beth A., additional, Piquette-Miller, Micheline, additional, Guirguis, Lisa M., additional, and McCarthy, Lisa M., additional

Published
2021
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149. LPG stove and fuel intervention among pregnant women reduce fine particle air pollution exposures in three countries: Pilot results from the HAPIN trial

Author

Liao, Jiawen, primary, Kirby, Miles A., additional, Pillarisetti, Ajay, additional, Piedrahita, Ricardo, additional, Balakrishnan, Kalpana, additional, Sambandam, Sankar, additional, Mukhopadhyay, Krishnendu, additional, Ye, Wenlu, additional, Rosa, Ghislaine, additional, Majorin, Fiona, additional, Dusabimana, Ephrem, additional, Ndagijimana, Florien, additional, McCracken, John P., additional, Mollinedo, Erick, additional, de Leon, Oscar, additional, Díaz-Artiga, Anaité, additional, Thompson, Lisa M., additional, Kearns, Katherine A., additional, Naeher, Luke, additional, Rosenthal, Joshua, additional, Clark, Maggie L., additional, Steenland, Kyle, additional, Waller, Lance A., additional, Checkley, William, additional, Peel, Jennifer L., additional, Clasen, Thomas, additional, Johnson, Michael, additional, Aravindalochanan, Vigneswari, additional, Bankundiye, Gloriose, additional, Barr, Dana Boyd, additional, Bussalleu, Alejandra, additional, Canuz, Eduardo, additional, Castañaza, Adly, additional, Chen, Yunyun, additional, Chiang, Marilú, additional, Craik, Rachel, additional, Davila-Roman, Victor G., additional, de las Fuentes, Lisa, additional, Elon, Lisa, additional, Espinoza, Juan Gabriel, additional, Garg, Sarada, additional, Hamid, Sarah, additional, Hartinger, Stella, additional, Harvey, Steven A., additional, Hengstermann, Mayari, additional, Hennessee, Ian, additional, Herrera, Phabiola M., additional, Hossen, Shakir, additional, Howards, Penelope P., additional, Jaacks, Lindsay, additional, Jabbarzadeh, Shirin, additional, Lenzen, Pattie, additional, Lovvorn, Amy E., additional, Mbabazi, Jane, additional, McCollum, Eric, additional, Meyers, Rachel, additional, Moulton, Lawrence, additional, Mukeshimana, Alexie, additional, Mutariyani, Bernard, additional, Natesan, Durairaj, additional, Nizam, Azhar, additional, Ntivuguruzwa, Jean de Dieu, additional, Papageorghiou, Aris, additional, Puttaswamy, Naveen, additional, Puzzolo, Elisa, additional, Quinn, Ashlinn, additional, Rajamani, Karthikeyan Dharmapuri, additional, Ramakrishnan, Usha, additional, Ramasami, Rengaraj, additional, Ramirez, Alexander, additional, Ryan, P. Barry, additional, Saidam, Sudhakar, additional, Sarnat, Jeremy A., additional, Simkovich, Suzanne, additional, Sinharoy, Sheela S., additional, Smith, Kirk R., additional, Swearing, Damien, additional, Thangavel, Gurusamy, additional, Toenjes, Ashley, additional, Valdes, Viviane, additional, Williams, Kendra N., additional, and Young, Bonnie N., additional

Published
2021
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150. Catalytic Atroposelective Synthesis of N-Aryl Quinoid Compounds

Author

Sagar D. Vaidya, Sean M. Maddox, Sean T. Toenjes, Jeffrey L. Gustafson, and Nobuyuki Yamamoto

Subjects
Chemistry, Drug discovery, Aryl, Enantioselective synthesis, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Colloid and Surface Chemistry
Abstract

Diarylamines and related scaffolds are among the most common chemotypes in modern drug discovery. While they can potentially possess two chiral axes, there are no studies on their enantioselective ...

Published
2020
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