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AIM: HIV infection is currently an incurable disease characterized by life-long drug utility. Its incurable causality and mechanism are still unknown to us. METHODS: To overcome this therapeutic setback, some breakthroughs should be made by utilizing different approaches. How to plan some experimental and clinical novelty for HIV curability is a modern challenge. In this article, new ideas and approaches for global HIV/AIDS therapeutic strategies are proposed and represented by scientific insights. RESULTS: Pharmaceutical characteristics, herbal medicine, novel drug targets, cutting-edge biotherapy, drug combination, animal modalities, and immune-stimuli for HIV latency, as well as clearance, are highlighted. DISCUSSION: To elucidate our understanding of curative treatment for HIV/AIDS, many new pathological discoveries, expansion, technical advances, and potential drug targets are constructed. After the discovery of novel pathogenesis and therapeutic evolution, HIV/AIDS therapeutic curability may become achievable and a reality. CONCLUSION: Transformation from animal model investigation to widespread therapies for larger volume of human population is a necessity in modern medicine. In this infectious treatment scenario, major breakthroughs in medicine and drug development are anticipated.

We construct a theoretical model to interpret the structural shock from the COVID-19 pandemic and the response of local labour market and industry specialization. The empirical study takes the large-scale online labour market of China to analyse firms’ hiring demand for 20 industries across 380 cities with monthly recruitment data from May 2017 to September 2020. Post-event quantitative analysis on job postings and employer demand highlighted that the pandemic resulted in an unemployment shock and industry- and city-level redistribution of the worker. China’s local job market resilience also revealed a regional imbalance, correlated with pandemic risk, city scale and industry structure.

Herein we described a catalytic epoxidation of α,β-enone with peroxide in situ generated via a predominant single electron transfer and a minor energy transfer pathways using inexpensive natural vitamin B2...

α-Keto ketals and benzannulated oxo-spiroketals have been regioselectively synthesized using a Sc3+-coordinated riboflavin tetraacetate photocatalyst with electron-deficient alkynes and alkynediols, respectively.

PurposeAs majority of studies of employee ownership (EO) take place in developed markets and primarily focus on the impact on firm performance, scholars have recently called for other markets, especially large developing markets to be considered, as well as alternative outcome measures.Design/methodology/approachThrough the examination of the implementation of EO by Chinese listed firms during the period of 2011–2019 with total 3,473 firms and 21,204 observations, the authors provide empirical evidence on the positive effect of EO on firm R&D investment within the rapidly growing Chinese market.FindingsThe authors find that the adoption of EO promotes higher level of firm R&D investment. This positive relationship is more evident among small firms, non-state-owned firms and local state-owned-firms, compared with their counterparts. As for the plausible channels, the authors find that adopting EO provides a favorable institutional environment, which attracts more technical staff, improves workplace quality, and encourages job stability and greater employee effort, leading to greater R&D investment.Originality/valueThough the connection between R&D investment/innovation and firm survival performance has been known for decades, the innovation side of outcomes has been ignored by EO research. Therefore, the authors explore the relationship between EO implementation and firm R&D investment within the rapidly growing Chinese market.

As mining progresses into deep ore deposits in Australia, geo-hazards such as coal burst and outbursts are becoming a major concern for mine workers. The occurrence of geo-hazards involved the ejection of coal lumps and sometimes large volumes of hazardous gases such as methane and carbon dioxide. Whilst it is extremely important to de-stress and de-gas the seam and adjacent strata before roadway development and install competent support systems such as steel mesh and bolt, the last line of protection will be the installation of a protective canopy on the Continuous Miner (CM), which is typically used for roadway developments, to shield mine workers from these deadly dynamic impacts of coal and rock resulting from a burst or outburst. This paper aims to introduce the design, manufacture and testing of an innovative modular protective structure on the CM in underground coal mines. The developed protective system can be easily assembled in the underground mining environment and provide a high level of protection against flying debris hazards in the event of a coal burst. The extensive experimental program and numerical simulations have confirmed the high performance of the protective system against high-speed impact loading by single and multiple coal rocks and projectiles.

AIM: To investigate the effect of modified Zhujing pill on retinal thickness and apoptosis in form deprivation myopia(FDM)mice.METHODS: Totally 72 C57BL/6J mice aged 3-week-old were randomly divided into control group 1, model group 1, intervention group 1, control group 2, model group 2 and intervention group 2, with 12 mice in each group. The first three groups were tested for 3wk and the last three groups were tested for 6wk, except for the groups of control 1 and control 2, all the mice used translucent goggles to cover their right eyes for form deprivation. The mice of intervention 1 and intervention 2 were respectively given intragastric administration modified Zhujing pill suspension 0.546g/(kg·d)(0.1mL/d)for 3wk at the beginning and after 3wk of the experiment. Same amount of saline was given to mice in other groups at the same time of modeling. The eye axis was measured before and after the experiment. At the end of the experiment, the eye of mice was taken for HE staining to observe the thickness changes of each layer of retina. Immunohistochemistry(IHC)and western blotting(WB)were used to detect Bcl-2 and Caspase3 expression of protein.RESULTS: At the end of the experiment, the axis of model group 1 was significantly higher than that of control group 1(P

Coal and gas outburst is tightly related to the existence of tectonic coal. Because large blocks of tectonic coals are difficult to be collected, reconstituted coal specimens are often used to study the mechanical properties. In this study, reconstituted coal specimens were prepared under different external forces. Then, triaxial compression tests were conducted under different confining pressures. The deviatoric stress, volumetric strain, axial strain and dilatancy ratio were analyzed. From the laboratory tests, the cohesion of reconstituted coal is positively related to the applied external force. Bonds are developed between coal particles. It is found that the deviatoric stress mainly contributes to bond breakage and internal friction. Under low confining pressure testing condition, the specimen is in over-consolidation state. The failure process is similar to the failure of intact coal. The deviatoric stress reaches the peak value. Then a strain-softening effect is observed with the bond breakage. But for normal consolidation scenario, the bond-breakage stress is smaller than the maximum internal friction force. With the increase of deviatoric stress, the shear stress exceeds the threshold limit value of bond breakage first and then, it exceeds the maximum internal force. Before the new unstable fracture development, extensive bond breakage happens. When the shear stress exceeds the maximum friction force, internal slippage occurs with sharp increases of dilatancy ratio. From this study, the failure behaviors of reconstituted coal are closely related to the stress conditions. The understanding of tectonic coal failure process is enhanced.

A Gram-stain-negative, aerobic, and yellow-pigmented bacterium, designated A3-108T, was isolated from seawater of the West Pacific Ocean. Cells were non-motile and rod-shaped, with carotenoid-type pigments. Strain A3-108T grew at pH 6.0–8.5 (optimum 6.5) and 15–40 °C (optimum 28 °C), in the presence of 0.5–10% (w/v) NaCl (optimum 1.0%). It possessed the ability to produce H2S. Based on the 16S rRNA gene analysis, strain A3-108T exhibited highest similarity with Aureisphaera salina A6D-50T (90.6%). Phylogenetic analysis shown that strain A3-108T affiliated with members of the family Flavobacteriaceae and represented an independent lineage. The principal fatty acids were iso-C15:0, iso-C17:0 3-OH, iso-C15:1 G, and summed feature 3 (C16:1ω7c and/or C16:1ω6c). The sole isoprenoid quinone was MK-6. The major polar lipids were phosphatidylethanolamine, one unidentified aminophospholipid, one unidentified aminolipid and one unidentified lipid. The ANIb, in silico DDH and AAI values among the genomes of strain A3-108T and three reference strains were 67.3–71.1%, 18.7–22.1%, and 58.8–71.4%, respectively. The G + C content was 41.0%. Distinctness of the phylogenetic position as well as differentiating chemotaxonomic and other phenotypic traits revealed that strain A3-108T represented a novel genus and species of the family Flavobacteriaceae, for which the name Luteirhabdus pelagi gen. nov., sp. nov. is proposed (type strain, A3-108T = CGMCC 1.18821T = KCTC 82563T).

Potato late blight caused by Phytophthora infestans is still one of the main factors limiting potato production. Epichloë spp. can provide host plants with various resistances, which makes them show great potential in the biological control of diseases. In this study, we explored the potential biological activity of crude extracts of 20 strains of Epichloë bromicola to control P. infestans. The crude extracts of strains 1 and 8 showed significant antifungal activity with an inhibition rate of 88% and 81%, respectively, and showed different effects on the mycelium morphology of P. infestans observed by scanning electron microscopy. Moreover, the two crude extracts demonstrated an interesting therapeutic and protective effect on potato late blight, and none of the extracts had an adverse effect against zebrafish embryos. A total of 13 metabolites were isolated from the crude extract of strain 8, and these tested compounds showed a weak antifungal effect and the inhibition rate was less than 80%. These findings suggested that strains 1 and 8 have potential for biocontrol of late potato blight.

This study aims to investigate the behavior of ground surface settlement in TBM double-line tunnels constructed under existing buildings and to devise a calculative representation for that behavior. Numerical simulation and field monitoring methods were used to examine the Zhongcong Tunnel in Chongqing Metro Line 9. The ground surface settlement was analyzed using an orthogonal test of 3D numerical simulation methods. The results showed that ground surface settlement was influenced by TBM tunneling parameters and the location of the existing building in the following manner. The existing building reduced the settlement trough width. Surface settlement was increased by frictional and palm surface thrust forces but reduced by grouting pressure. The settlement trough width of the first excavation iz correlated with that of the last excavation iy. To accommodate the influence of existing buildings, the tilt factor of the settlement trough TR was introduced to improve the formula for calculating the ground surface settlement of TBM double-line tunnels. The improved formula was validated by comparing the calculated results with actual measurements.

We study the impact of formal and informal institutions perceived and experienced by firms on their innovation using the 2012 World Bank Enterprise Survey data in China. We propose a framework to identify different innovator types of firms. Our analysis shows that (1) perceived constraints from the governmental system make firms more likely to be innovators than non-innovators; (2) perceived constraints from the legal system make firms more likely to be imitators than innovators; (3) lack of formal finance makes firms more likely to be non-innovators than innovators; (4) prevalence of bribery makes firms more likely to be non-innovators than innovators but less likely to be innovation pretenders than innovators. Our study enriches institutional theory and innovation research by establishing a framework that encompasses multiple dimensions of formal and informal institutions perceived and experienced by firms and the impacts of such perception and experience on firms’ propensity to become certain type of innovator.

The stability of underground rock engineering is strongly affected by cavities. To analyse the dynamic response and fracture evolution of rock mass containing cavities, intact specimens and those containing a single rectangular cavity or two rectangular cavities with different layouts were tested by using split Hopkinson pressure bar (SHPB) test system under three levels of nitrogen gas actuating pressures (0.35 MPa, 0.40 MPa and 0.45 MPa). During tests, failure process was recorded by a high-speed camera. Then, digital image correlation (DIC) techniques combined with displacement trend line method was employed to investigate the crack evolution and failure modes. Moreover, absorbed energy per unit volume was calculated to evaluate specimen fragmentation. Test results reveal that under a given impact pressure, the dynamic loading capacity is apparently higher for intact specimens than for those containing cavities. Although the incident energy has varying influence on the fragmentation of specimens in different cases, the crack evolution and failure modes seem to be independent on incident energy but mainly associated with cavity number and layout. The existence of cavities contributes to the degradation of dynamic loading capacity and absorbed energy. For specimens containing two cavities, the twin-cavity system with the connecting angle of 45° exhibits the maximum weakening effect on the mechanical parameters. In comparison, when the connecting angle is 90°, the specimens containing two cavities hold the maximum average dynamic loading capacity, which approximates that of the specimens containing a single cavity.

The fragmentation of coal produces abundant coal gases and is presumed to be the defining characteristic of coal and gas outbursts. Knowing the mechanism of these catastrophic hazards is one of the most important breakthroughs in mining geology. In the outburst process, coal spallation represents a unique failure type and typically leaves behind a spallation area (with a series of fracture textures) in the coal seam. Revealing its features and formation mechanism is crucial in accurately interpreting the outburst process. In this study, we conducted a series of outburst experiments with different gases, including CO2, N2, and He. We establish that a spallation area can develop spontaneously during CO2 and N2 tests, whereas an outburst caused by He tests (even under stressed conditions) does not produce a spallation area. That is, the spallation area cannot be observed in non-absorbable gas outbursts. We, therefore, focus on the role of coal gas in spallation and propose a viable mechanism to explain its formation. During the outburst development stage, the influence of gas ad-/desorption is critical, as it controls the width of the spallation area and the spallation thickness. In contrast, stress is not a necessary condition. Whether a spallation area will be produced is particularly determined by the generation of a sufficient internal pressure gradient. Moreover, because of gas desorption, the total outburst energy can be increased by 1.84–5.30 times; and the mean outburst propagation velocity and the mean frequency of coal spallation ejected can be enhanced by 0.38–8.76% and 1.28–12.07%, respectively. Consequently, the destructiveness of outbursts depends on the contribution of desorbed gas.

This paper presents a series of novel hybrid columns incorporating emerging materials, being the alternative to pumpable standing supports used in underground mines. The infill material of these hy...

This research reviewed the mechanics and gas desorption properties of intact coal, and tested the crushing work ratios of different intact coals, and then, studied the stress conditions for the failure or crushing of intact coal and the gas demand for the pulverization of intact coal particles. When a real-life outburst case is examined, the required minimum stress for intact coal outburst is estimated. The study concludes that the crushing work ratios of three intact coal samples vary from 294.3732 to 945.8048 J/m2. For the real-life case, more than 2300 MJ of transport work is needed, and 10062.09, 7046.57 and 5895.47 m3 of gas is required when the gas pressure is 1, 2 and 3 MPa, respectively. The crushing work exceeds the transport work and even reaches 13.96 times of the transport work. How to provide such an enormous crushing work is an energy-limiting factor for the outburst in intact coal. The strain energy is needed for the crushing work, and the required minimum stress is over 54.35 MPa, even reaching 300.44 MPa. These minimum stresses far exceed the in-situ vertical and horizontal stresses that can be provided at the 300–700 m mining depth range.

Effectively reducing manufacturing carbon dioxide (CO2) emissions is a vital strategy for China to curb its rapidly rising carbon footprint. Features of such a reduction in manufacturing include an increase in the share of high-tech manufacturing and optimization of the energy consumption structure. This study aims to analyze the case of Shenzhen, a unique post-industrial innovative manufacturing megacity, for its leading experience in China’s manufacturing transition. Disaggregated manufacturing emissions data of Shenzhen, including 27 sub-sectors in four categories, were collected, and driving factors were identified by the logarithmic mean Divisia index (LMDI) method. The results suggest that: (1) CO2 emissions from Shenzhen’s manufacturing show a phased difference between 2008–2012 and 2012–2020. CO2 emissions embodied in electricity consumption have increased by over 30% in the former period and have remained stable at a high level of over 90%. (2) Significant heterogeneity of CO2 emissions in various manufacturing sectors is revealed, with the largest emissions sources being factories that make communication equipment, computers, and other electronic equipment. (3) Lower carbon intensity is the primary factor in reducing CO2 emissions, while the economic activity effect of manufacturing possesses a stimulating impact. (4) The marginal impact of restructuring on CO2 emissions is insignificant since the manufacturing and energy structures of Shenzhen have been upgraded to a low carbon level. Therefore, strengthening the power saving management and improving the energy efficiency of the manufacturing, rather than optimizing the manufacturing and final energy structures, will be a necessary potential solution to the problem of how to reduce CO2 emissions in Shenzhen’s manufacturing.

Under the pressure of rapid urbanization, the spatiotemporal dynamics of urban green spaces (UGS) have enormous impacts on the local ecological system and environment at different scales. In this study, UGS in Hefei City, which has experienced rapid urbanization from 1995 to 2015, were extracted based on time-series Landsat-5 TM and Landsat-8 OLI images, and different types of parks were mapped based on GF-2 images combined with multi-source metadata. Dynamic patterns of green space were examined by drawing the spatial variations of green space at the city, inner city, and park scales. Results revealed that: (1) At the city level, UGS decreased with the rapid urbanization, especially farmland sharply lost in areas around existing urban areas and along the transportation corridors. (2) At the inner-city level, concentric analyses showed that UGS changes in different rings had unique trends, and the dynamic changes were the most significant in Rings 2 and 3. Comparative analysis of old and new districts showed that the common characteristics of UGS changes were the transfer-out of farmland and the transfer-in of built-up land, and the newer the region, the more intense the changes. (3) At the park level, the number and area of urban parks were increasing from the center to the periphery, and the type of park gradually changed from single to rich. Significant spatial heterogeneity was identified in the landscape patterns of urban parks based on fishnet cell analysis. It is fundamental to assign urban construction land for socio-economic development, while planning UGS at different scales; moreover, integrating different green space-related policies could protect the UGS and maintain its stability. Only in this way can UGS combine economic, social, and ecological benefits under the background of rapid urbanization.

Members of Apiales are monophyletic and radiated in the Late Cretaceous. Fruit morphologies are critical for Apiales evolution and negative selection and mutation pressure play important roles in environmental adaptation. Apiales include many foods, spices, medicinal, and ornamental plants, but the phylogenetic relationships, origin and divergence, and adaptive evolution remain poorly understood. Here, we reconstructed Apiales phylogeny based on 72 plastid genes from 280 species plastid genomes representing six of seven families of this order. Highly supported phylogenetic relationships were detected, which revealed that each family of Apiales is monophyletic and confirmed that Pennanticeae is a member of Apiales. Genera Centella and Dickinsia are members of Apiaceae, and the genus Hydrocotyle previously classified into Apiaceae is confirmed to belong to Araliaceae. Besides, coalescent phylogenetic analysis and gene trees cluster revealed ten genes that can be used for distinguishing species among families of Apiales. Molecular dating suggested that the Apiales originated during the mid-Cretaceous (109.51 Ma), with the families' radiation occurring in the Late Cretaceous. Apiaceae species exhibit higher differentiation compared to other families. Ancestral trait reconstruction suggested that fruit morphological evolution may be related to shifts in plant types (herbaceous or woody), which in turn is related to the distribution areas and species numbers. Codon bias and positive selection analyses suggest that negative selection and mutation pressure may play important roles in environmental adaptation of Apiales members. Our results improve the phylogenetic framework of Apiales and provide insights into the origin, divergence, and adaptive evolution of this order and its members.

In the future, suicide risk prediction and management should be transformed from psychiatrist’s judgment (mental illness-like symptoms) into modern technique-guided diagnostics and target drug therapeutics in larger clinical settings. To embrace modern scientific and technological advances, a number of unique diagnostic and therapeutic approaches must be established. This Article provides some important ideas and mechanisms proposed by translational programs.

CO2 geo-sequestration in unminable coal seams is one promising method to mitigate greenhouse gas emissions and would be a means of cleaner production. At the same time, the injected CO2 can enhance coalbed methane recovery and offsets the economic cost for CO2 transportation and injection. However, this technology is still at its primary stage and so far, no large scale of field CO2 injection has been implemented. One of the main difficulties encountered in this process is the permeability reduction induced by CO2 injection and as a result, the injection rate is sharply dropped in the later period. In this paper, detailed laboratory experiments are conducted to investigate the permeability reduction effects during CO2 injections. The dynamic permeability reduction effects are measured with the continuous CO2 injection under different confining pressure conditions. Permeability reduction effects of 13 %–77 % are obtained with respect to the CO2 exposure time in different testings. In low permeability scenario, the permeability reduction effects are severer. Specifically, when the absolute permeability is 1mD, 0.42mD, 0.18mD and 0.03mD, the permeability reduction is 13 %, 36 %, 48 % and 77 %, respectively. Compared with the coal triaxial adsorption tests, it is suggested that the permeability equilibrium is not equal to the adsorption equilibrium. The triaxial adsorption equilibrium process takes much longer time than that of permeability equilibrium process. Based on the testing results, a novel dynamic permeability model is proposed to illustrate the permeability evolutions. The existence of weak internal surface influences the matrix strain and the permeability. This model is also validated by other’s experimental results and can be used for explaining coal seam permeability reduction effects of CO2 injection in coal seams.

Abstract: Anticancer drug development is growing complexity and multi-factorials, which demands robust drug evaluative architecture in experimental and preclinical studies. To increase the number of drug licensing, biochemical, pharmacological, technical and economic changes (balance and integration) in evaluative systems should be focused in world labs. Despite a great progress, treatment breakthroughs and drug industry need new minds and more competitive technology (new generation of in vitro test systems) were emerging in the past. Overall, drug evaluative systems consisted half of anticancer drug development and licensing (medicinal chemistry and pharmacology in total) from initial screening to clinical validity. Its advances greatly impact the outcomes of drug production (rates of final drug licensing and efficacy of therapeutics in the clinic). In this regards, creative ideas and new techniques will change the norm and convention of drug screening and mechanic exploration in the future. This article provides multi-disciplinary approaches for experimental and preclinical anticancer drug evaluations, selections and combinations (chemistry and biomedicine). Future trends for drug evaluative systems are especially highlighted in depth, multilateral and multidisciplinary.

Panax ginseng C. A. Meyer (Ginseng) has traditionally been used to treat diabetes. Polysaccharide is the main active component of ginseng, and has been proved to have hypoglycaemic and hypolipidaemic effects, but its mechanism remains unclear.This study aimed to evaluate the effect and the potential mechanism of rhamnogalacturonan-I enriched pectin (GPS-1) from steamed ginseng on lipid metabolism in type 2 diabetes mellitus (T2DM) rats.GPS-1 was prepared by water extraction, ion-exchange and gel chromatography. High-glucose/high-fat diet combined with streptozotocin was used to establish T2DM rat models, and lipid levels in serum and liver were tested. 16S rRNA sequencing and gas chromatography-mass spectrometry were used to detect the changes of gut microbiota and metabolites. The protein and mRNA levels of lipid synthesis-related genes were detected by Western blot and quantitative real-time polymerase chain reaction.The polyphagia, polydipsia, weight loss, hyperglycaemia, hyperlipidaemia and hepatic lipid accumulation in T2DM rats were alleviated after GPS-1 intervention. GPS-1 modulated the gut microbiota composition of T2DM rats, increased the levels of short-chain fatty acids, and promoted the secretion of glucagon-like peptide-1 and peptide tyrosine tyrosine. Further, GPS-1 activated AMP-activated protein kinases, phosphorylated acetyl-CoA carboxylase, reduced the expression of sterol regulatory element-binding protein-1c and fatty acid synthases in T2DM rats.The regulation effects of GPS-1 on lipid metabolism in T2DM rats are related to the regulation of gut microbiota and activation of AMP-activated protein kinase pathway.

Essential oils produced by Cymbopogon distans and Ruta graveolens with a similar Chinese name could be explained as book fragrance in the Chinese idiom 'shu xiang men di', namely, a wealthy intellectual family according to ancient Chinese. Therefore, volatile oils from these two plants and their main compounds were tested to explore their antifungal, repellent, and insecticide actions. In this study, the essential olis (EO) of C. distans exhibited significant antifungal activity against Rhizopus stolonifera (97 %), Mucor racemosus (97 %), and Trichoderma viride (84 %); its main compounds exhibit interesting activity, such as methyleugenol (87 %) and elemicine (85 %) against T. viride and butyl hydroxytoluene against M. racemosus (90 %) and R. stolonifera (95 %). The EO of R. graveolens and other major chemical constituents showed weak inhibitory effects against other fungi (Aspergillus flavus and Fusarium oxysporum). Then, EO (C. distans and R. graveolens) and its main compounds exhibited obvious repellent activity (more than 85 %) at a concentration of 16 nL/cm

BACKGROUND In general, atlantoaxial dislocation is rare due to the stability of the C1-C2 complex. Traumatic atlantoaxial dislocations are usually anterior and accompanied by odontoid fractures. Posterior atlantoaxial dislocations are rare, and complete posterior dislocation without associated fracture is even more rare. A case of early recurrence of posterior atlantoaxial dislocation without fracture being in therapy of first closed reduction and then open reduction has not been previously reported. CASE SUMMARY A 45-year-old female presented with traumatic posterior atlantoaxial dislocation (TPAD) of C1-C2 without associated fractures, and Frankel Grade B spinal cord function. She was successfully managed by immediate closed reduction under skull traction. Unexpectedly, 17 d later, re-dislocation was discovered. On day 28, closed reduction was performed as before but failed. Then, open reduction and posterior internal fixation with autologous iliac bone grafts was performed. By 6 mo after surgery, atlantoaxial joint fusion was achieved, and neurological function had recovered to Frankel Grade E. At 12 mo follow-up, she had lost only 15° of cervical rotation, and atlantoaxial complex instability in joint flexing and extending were no longer observed under fluoroscopy. CONCLUSION Early assessment of transverse ligament is critical for TPAD without fracture avoiding re-dislocation after closed reduction.

Household debt is an important part of household financial decision-making, and commercial medical insurance has gradually become an important tool for households to use in improving their household balance sheets. Based on 2017 China Household Finance Survey (CHFS) data, this paper studies the impact of commercial medical insurance participation on household debt and analyzes the heterogeneity of household conditions, such as the location of the household, the age of the household head, and the health status of members. The study found that households participating in commercial medical insurance are more likely to be indebted, and their degree of debt is higher than that of households without commercial medical insurance. For urban households, young households, and households with healthy members, the participation of commercial medical insurance has a high effect on the likelihood and the degree of debt. Therefore, while strengthening household insurance awareness, the government should promote the strengthening of the risk-resistance function of commercial medical insurance and encourage financial institutions to design products that combine insurance and credit to release households’ consumption and investment potential.