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38,381 results on '"Timmermans, An"'

101. Transition Processes in Dutch Spatial Planning and Water Management: A Shift to the Natural

Author

Zoë van Eldik, Wim Timmermans, and Wim de Haas

Subjects
climate adaptation, landscape-based visioning, netherlands 2120, water management, City planning, HT165.5-169.9
Abstract

Climate change is causing more extreme weather conditions in the Netherlands. In response, local governments such as Provinces, Municipalities, and regional Water Boards are encouraged to explore more nature-inclusive ways to keep society safe from flooding and drought. This is considered a transition from the earlier belief that environmental and societal challenges can be solved solely through technical engineering. Instead, landscape-based, climate-adaptive visions offer alternatives on how Dutch regions can maintain water security while also incorporating space for biodiversity, climate mitigation, healthy livelihood and expanding populations. So far, not much is known about the challenges project leaders from different organisations and local governments are facing during the development and implementation of such visions. To address this gap, we used the concept of learning history to build an archive capturing the insider perspective of project leaders tasked with co-creating landscape-based, climate-adaptive visions for future spatial planning and water management across four regions of the Netherlands. By observing and interviewing project leaders, we noticed how co-creating long-term visions enabled more climate-conscious dialogues between local government authorities and civil stakeholder groups. Reflecting on this archive, we gained insights into the strategic challenges associated with adopting biophysical processes as a foundational framework for future spatial development and policy-making. Furthermore, we documented examples of tactical approaches employed by project leaders to navigate these challenges effectively.

Published
2024
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102. Technology supported High Intensity Training in chronic non-specific low back pain (the Techno-HIT trial): study protocol of a randomised controlled trial

Author

Mira Meeus, Wim Marneffe, Julie Sylvie van Eetvelde, Annick A A Timmermans, Karin Coninx, Kristof Kempeneers, Timo Meus, Iris Meuwissen, Nathalie Anne Roussel, Gaetane Stassijns, and Jonas Verbrugghe

Subjects
Medicine (General), R5-920
Abstract

Chronic low back pain (CLBP) is one of the most common chronic musculoskeletal disorders worldwide. Guidelines recommend exercise therapy (ET) in CLBP management, but more research is needed to investigate specific ET modalities and their underlying mechanisms. The primary goal of this study is to evaluate the short-term and long-term effectiveness of a time-contingent individualised high-intensity training (HIT) protocol on disability compared with a time-contingent moderate-intensity training (MIT) as used in usual care, in persons with severely disabling CLBP. Additionally, the effectiveness on central effects, the added value of prolonged training at home and technology support, and the cost-effectiveness are evaluated. In this randomised controlled trial, CLBP patients will be randomly divided into three groups of 56 participants. Group 1, ‘TechnoHIT’, receives HIT with technology-support in the home-phase. Group 2, ‘HIT’, receives HIT without technology support. Group 3, ‘MIT’, receives MIT, reflecting training intensity as used in usual care. The primary outcome is patient-reported disability, measured by the Modified Oswestry Disability Index. Secondary outcomes include quantitative sensory testing, psychosocial factors, broad physical fitness, quality of life, cost-effectiveness, adherence and usability of technology. Trial registration number NCT06491121.

Published
2024
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103. The impact of shipping on the air quality in European port cities with a detailed analysis for Rotterdam

Author

J.P. Tokaya, R. Kranenburg, R.M.A. Timmermans, P.W.H.G. Coenen, B. Kelly, J.S. Hullegie, T. Megaritis, and G. Valastro

Subjects
Environmental pollution, TD172-193.5, Meteorology. Climatology, QC851-999
Abstract

Air quality in cities with large maritime ports is considerably impacted by emissions from shipping activity which is of a growing relevance due to an increasing relative contribution. To explore the extent of shipping emissions to ambient air quality, simulations with the chemical transport model LOTOS-EUROS (LOng Term Ozone Simulation – EURopean Operational Smog model) were performed for the year 2018 at an approximate 1 × 1 km resolution for six European cities with large ports, i.e., Rotterdam, Antwerp, Hamburg, Amsterdam, Le Havre, and London. It was found that depending on the investigated city, 6.5%–62% of the nitrogen dioxide (NO2) concentration in the city centres is attributable to shipping activities. This corresponds to contributions of 1.8–11.5 μg/m3 to the ambient air NO2 concentrations. The average NO2 contribution of shipping in these six cities was 28% (7.1 μg/m3). The largest relative contribution was found for Le Havre where 62% (10.8 μg/m3) of the annual average NO2 concentration was caused by shipping emissions. The largest absolute contribution is found for the city centre of Hamburg with 11.5 μg/m3 (41%). The lowest absolute and relative contribution (respectively 1.8 μg/m3 and 6.5%) are found for London, also having the smallest port in terms of tonnage throughput, which is one of the influential factors that determine emission totals, investigated in this study. For the other investigated pollutants, i.e., PM2.5, PM10 and SO2, contributions from shipping were less pronounced with average contribution for all cities of 10% (1.2 μg/m3) 7% (1.5 μg/m3) and 4% (0.16 μg/m3) respectively. To assess the effect of model choices on these results, this study also looked into the choice of simulation resolution and relations between meteorological parameters and NO2 concentrations. Following simulations with varying chemical transport model resolutions (1 × 1 km to 24 × 24 km), it is found that a decrease in ambient air pollutant concentrations away from localized emission sources is more pronounced at higher (1 × 1 km) model resolutions and source contributions are influenced more significantly than total concentrations. Considering meteorology, generally low wind speeds (1–2 m/s) lead to high NO2 concentration in city centres. For the cities where the port is much closer to the city centre (e.g., London, Le Havre, Hamburg and Antwerp) the absolute NO2 concentrations as well as the contributions from shipping emissions become highest for windless conditions. The high concentrations (>60 μg/m3 NO2) only occur when wind speeds fall below 6 m/s.

Published
2024
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104. Longitudinal associations of air pollution and green space with cardiometabolic risk factor clustering among children in the Netherlands

Author

Mingwei Liu, Ilonca Vaartjes, Gerard Hoek, Vincent W.V. Jaddoe, Susana Santos, Anton Schreuder, Tanja G.M. Vrijkotte, Diederick E. Grobbee, and Erik J. Timmermans

Subjects
Cardiometabolic diseases, Environmental health, Cohort study, Pediatrics, Environmental sciences, GE1-350
Abstract

Background: This study examines longitudinal associations of air pollution and green space with cardiometabolic risk among children in the Netherlands. Methods: Three Dutch prospective cohorts with a total of 13,822 participants aged 5 to 17 years were included: (1) the Amsterdam Born Children and their Development (ABCD) study from Amsterdam (n = 2,547), (2) the Generation R study from Rotterdam (n = 5,431), and (3) the Lifelines study from northern Netherlands (n = 5,844). Air pollution (PM2.5, PM10, NO2, and elemental carbon (EC)) and green space exposures (density in multiple Euclidean buffer sizes) from 2006 to 2017 at home address level were used. Cardiometabolic risk factor clustering was assessed by a MetScore, which was derived from a confirmatory factor analysis of six cardiometabolic risk factors to assess the overall risk. Linear regression models with change in Metscore as the dependent variable, adjusted for multiple confounders, were conducted for each cohort separately. Meta-analyses were used to pool cohort-specific estimates. Results: Exposure to higher levels of NO2 and EC was significantly associated with increases in MetScore in Lifelines (per SD higher exposure: βNO2 = 0.006, 95 % CI = 0.001 to 0.010; βEC = 0.008, 95 % CI = 0.002 to 0.014). In the other two cohort studies, these associations were in the same direction but these were not significant. Higher green space density in 500-meter buffer zones around participants’ residential addresses was not significantly associated with decreases of MetScore in all three cohorts. Higher green space density in 2000-meter buffer zones was significantly associated with decreases of MetScore in ABCD and Lifelines (per SD higher green space density: βABCD = -0.008, 95 % CI = -0.013 to −0.003; βLifelines = -0.002, 95 % CI = -0.003 to −0.00003). The pooled estimates were βNO2 = 0.003 (95 % CI = -0.001 to 0.006) for NO2, βEC = 0.003 (95 % CI = -0.001, 0.007) for EC, and β500m buffer = -0.0014 (95 % CI = -0.0026 to −0.0001) for green space. Conclusions: More green space exposure at residence was associated with decreased cardiometabolic risk in children. Exposure to more NO2 and EC was also associated with increased cardiometabolic risk.

Published
2024
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107. Zero Trust and Compliance with Industry Frameworks and Regulations : A Structured Zero Trust Approach to Improve Cybersecurity and Reduce the Compliance Burden

Author

Bobbert, Yuri, Timmermans, Tim, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2024
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110. Precise near-infrared photometry, accounting for precipitable water vapour at SPECULOOS Southern Observatory

Author

Pedersen, Peter P., Murray, C. A., Queloz, D., Gillon, M., Demory, B. O., Triaud, A. H. M. J., de Wit, J., Delrez, L., Dransfield, G., Ducrot, E., Garcia, L. J., Chew, Y. Gómez Maqueo, Günther, M. N., Jehin, E., McCormac, J., Niraula, P., Pozuelos, F. J., Rackham, B. V., Schanche, N., Sebastian, D., Thompson, S. J., Timmermans, M., and Wells, R.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

The variability induced by precipitable water vapour (PWV) can heavily affect the accuracy of time-series photometric measurements gathered from the ground, especially in the near-infrared. We present here a novel method of modelling and mitigating this variability, as well as open-sourcing the developed tool -- Umbrella. In this study, we evaluate the extent to which the photometry in three common bandpasses (r', i', z'), and SPECULOOS' primary bandpass (I+z'), are photometrically affected by PWV variability. In this selection of bandpasses, the I+z' bandpass was found to be most sensitive to PWV variability, followed by z', i', and r'. The correction was evaluated on global light curves of nearby late M- and L-type stars observed by SPECULOOS' Southern Observatory (SSO) with the I+z' bandpass, using PWV measurements from the LHATPRO and local temperature/humidity sensors. A median reduction in RMS of 1.1% was observed for variability shorter than the expected transit duration for SSO's targets. On timescales longer than the expected transit duration, where long-term variability may be induced, a median reduction in RMS of 53.8% was observed for the same method of correction., Comment: Accepted for publication in MNRAS, 10 pages, 7 figures, 3 tables

Published
2022
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111. The TESS Grand Unified Hot Jupiter Survey. II. Twenty New Giant Planets

Author

Yee, Samuel W., Winn, Joshua N., Hartman, Joel D., Bouma, Luke G., Zhou, George, Quinn, Samuel N., Latham, David W., Bieryla, Allyson, Rodriguez, Joseph E., Collins, Karen A., Alfaro, Owen, Barkaoui, Khalid, Beard, Corey, Belinski, Alexander A., Benkhaldoun, Zouhair, Benni, Paul, Bernacki, Krzysztof, Boyle, Andrew W., Butler, R. Paul, Caldwell, Douglas A., Chontos, Ashley, Christiansen, Jessie L., Ciardi, David R., Collins, Kevin I., Conti, Dennis M., Crane, Jeffrey D., Daylan, Tansu, Dressing, Courtney D., Eastman, Jason D., Essack, Zahra, Evans, Phil, Everett, Mark E., Fajardo-Acosta, Sergio, Forés-Toribio, Raquel, Furlan, Elise, Ghachoui, Mourad, Gillon, Michaël, Hellier, Coel, Helm, Ian, Howard, Andrew W., Howell, Steve B., Isaacson, Howard, Jehin, Emmanuel, Jenkins, Jon M., Jensen, Eric L. N., Kielkopf, John F., Laloum, Didier, Leonhardes-Barboza, Naunet, Logsdon, Sarah E., Lubin, Jack, Lund, Michael B., MacDougall, Mason G., Mann, Andrew W., Maslennikova, Natalia A., Massey, Bob, McLeod, Kim K., Muñoz, Jose A., Newman, Patrick, Orlov, Valeri, Plavchan, Peter, Popowicz, Adam, Pozuelos, Francisco J., Pritchard, Tyler A., Radford, Don J., Reefe, Michael, Ricker, George R., Rudat, Alexander, Safonov, Boris S., Schwarz, Richard P., Schweiker, Heidi, Scott, Nicholas J., Seager, S., Shectman, Stephen A., Stockdale, Chris, Tan, Thiam-Guan, Teske, Johanna K., Thomas, Neil B., Timmermans, Mathilde, Vanderspek, Roland, Vermilion, David, Watanabe, David, Weiss, Lauren M., West, Richard G., Van Zandt, Judah, Zejmo, Michal, and Ziegler, Carl

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

NASA's Transiting Exoplanet Survey Satellite (TESS) mission promises to improve our understanding of hot Jupiters by providing an all-sky, magnitude-limited sample of transiting hot Jupiters suitable for population studies. Assembling such a sample requires confirming hundreds of planet candidates with additional follow-up observations. Here, we present twenty hot Jupiters that were detected using TESS data and confirmed to be planets through photometric, spectroscopic, and imaging observations coordinated by the TESS Follow-up Observing Program (TFOP). These twenty planets have orbital periods shorter than 7 days and orbit relatively bright FGK stars ($10.9 < G < 13.0$). Most of the planets are comparable in mass to Jupiter, although there are four planets with masses less than that of Saturn. TOI-3976 b, the longest period planet in our sample ($P = 6.6$ days), may be on a moderately eccentric orbit ($e = 0.18\pm0.06$), while observations of the other targets are consistent with them being on circular orbits. We measured the projected stellar obliquity of TOI-1937A b, a hot Jupiter on a 22.4 hour orbit with the Rossiter-McLaughlin effect, finding the planet's orbit to be well-aligned with the stellar spin axis ($|\lambda| = 4.0\pm3.5^\circ$). We also investigated the possibility that TOI-1937 is a member of the NGC 2516 open cluster, but ultimately found the evidence for cluster membership to be ambiguous. These objects are part of a larger effort to build a complete sample of hot Jupiters to be used for future demographic and detailed characterization work., Comment: 67 pages, 11 tables, 13 figures, 2 figure sets. Resubmitted to ApJS after revisions

Published
2022
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112. Searches for Ultra-High-Energy Photons at the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Pierre Auger Observatory, being the largest air-shower experiment in the world, offers an unprecedented exposure to neutral particles at the highest energies. Since the start of data taking more than 18 years ago, various searches for ultra-high-energy (UHE, $E\gtrsim10^{17}\,\text{eV}$) photons have been performed: either for a diffuse flux of UHE photons, for point sources of UHE photons or for UHE photons associated with transient events like gravitational wave events. In the present paper, we summarize these searches and review the current results obtained using the wealth of data collected by the Pierre Auger Observatory., Comment: Review article accepted for publication in Universe (special issue on ultra-high energy photons)

Published
2022
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113. Search for photons above 10$^{19}$ eV with the surface detector of the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Krohm, N., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We use the surface detector of the Pierre Auger Observatory to search for air showers initiated by photons with an energy above $10^{19}$ eV. Photons in the zenith angle range from 30$^\circ$ to 60$^\circ$ can be identified in the overwhelming background of showers initiated by charged cosmic rays through the broader time structure of the signals induced in the water-Cherenkov detectors of the array and the steeper lateral distribution of shower particles reaching ground. Applying the search method to data collected between January 2004 and June 2020, upper limits at 95\% CL are set to an $E^{-2}$ diffuse flux of ultra-high energy photons above $10^{19}$ eV, $2{\times}10^{19}$ eV and $4{\times}10^{19}$ eV amounting to $2.11{\times}10^{-3}$, $3.12{\times}10^{-4}$ and $1.72{\times}10^{-4}$ km$^{-2}$ sr$^{-1}$ yr$^{-1}$, respectively. While the sensitivity of the present search around $2 \times 10^{19}$ eV approaches expectations of cosmogenic photon fluxes in the case of a pure-proton composition, it is one order of magnitude above those from more realistic mixed-composition models. The inferred limits have also implications for the search of super-heavy dark matter that are discussed and illustrated., Comment: 21 pages, 8 figures

Published
2022

114. Two temperate super-Earths transiting a nearby late-type M dwarf

Author

Delrez, L., Murray, C. A., Pozuelos, F. J., Narita, N., Ducrot, E., Timmermans, M., Watanabe, N., Burgasser, A. J., Hirano, T., Rackham, B. V., Stassun, K. G., Van Grootel, V., Aganze, C., Cointepas, M., Howell, S., Kaltenegger, L., Niraula, P., Sebastian, D., Almenara, J. M., Barkaoui, K., Baycroft, T. A., Bonfils, X., Bouchy, F., Burdanov, A., Caldwell, D. A., Charbonneau, D., Ciardi, D. R., Collins, K. A., Daylan, T., Demory, B. -O., de Wit, J., Dransfield, G., Fajardo-Acosta, S. B., Fausnaugh, M., Fukui, A., Furlan, E., Garcia, L. J., Gnilka, C. L., Chew, Y. Gómez Maqueo, Gómez-Muñoz, M. A., Günther, M. N., Harakawa, H., Heng, K., Hooton, M. J., Hori, Y., Ikoma, M., Jehin, E., Jenkins, J. M., Kagetani, T., Kawauchi, K., Kimura, T., Kodama, T., Kotani, T., Krishnamurthy, V., Kudo, T., Kunovac, V., Kusakabe, N., Latham, D. W., Littlefield, C., McCormac, J., Melis, C., Mori, M., Murgas, F., Palle, E., Pedersen, P. P., Queloz, D., Ricker, G., Sabin, L., Schanche, N., Schroffenegger, U., Seager, S., Shiao, B., Sohy, S., Standing, M. R., Tamura, M., Theissen, C. A., Thompson, S. J., Triaud, A. H. M. J., Vanderspek, R., Vievard, S., Wells, R. D., Winn, J. N., Zou, Y., Zúñiga-Fernández, S., and Gillon, M.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

In the age of JWST, temperate terrestrial exoplanets transiting nearby late-type M dwarfs provide unique opportunities for characterising their atmospheres, as well as searching for biosignature gases. We report here the discovery and validation of two temperate super-Earths transiting LP 890-9 (TOI-4306, SPECULOOS-2), a relatively low-activity nearby (32 pc) M6V star. The inner planet, LP 890-9b, was first detected by TESS (and identified as TOI-4306.01) based on four sectors of data. Intensive photometric monitoring of the system with the SPECULOOS Southern Observatory then led to the discovery of a second outer transiting planet, LP 890-9c (also identified as SPECULOOS-2c), previously undetected by TESS. The orbital period of this second planet was later confirmed by MuSCAT3 follow-up observations. With a mass of 0.118$\pm$0.002 $M_\odot$, a radius of 0.1556$\pm$0.0086 $R_\odot$, and an effective temperature of 2850$\pm$75 K, LP 890-9 is the second-coolest star found to host planets, after TRAPPIST-1. The inner planet has an orbital period of 2.73 d, a radius of $1.320_{-0.027}^{+0.053}$ $R_\oplus$, and receives an incident stellar flux of 4.09$\pm$0.12 $S_\oplus$. The outer planet has a similar size of $1.367_{-0.039}^{+0.055}$ $R_\oplus$ and an orbital period of 8.46 d. With an incident stellar flux of 0.906 $\pm$ 0.026 $S_\oplus$, it is located within the conservative habitable zone, very close to its inner limit. Although the masses of the two planets remain to be measured, we estimated their potential for atmospheric characterisation via transmission spectroscopy using a mass-radius relationship and found that, after the TRAPPIST-1 planets, LP 890-9c is the second-most favourable habitable-zone terrestrial planet known so far. The discovery of this remarkable system offers another rare opportunity to study temperate terrestrial planets around our smallest and coolest neighbours., Comment: 31 pages, 19 figures, 7 tables. Accepted for publication in A&A

Published
2022
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115. The dynamics of viruslike capsid assembly and disassembly

Author

Timmermans, Suzanne B. P. E., Ramezani, Alireza, Montalvo, Toni, Nguyen, Mark, van der Schoot, Paul, van Hest, Jan C. M., and Zandi, Roya

Subjects
Physics - Biological Physics
Abstract

Cowpea chlorotic mottle virus (CCMV) is a widely used model for virus replication studies. A major challenge lies in distinguishing between the roles of the interaction between coat proteins and that between the coat proteins and the viral RNA in assembly and disassembly processes. Here, we report on the spontaneous and reversible size conversion of the empty capsids of a CCMV capsid protein functionalized with a hydrophobic elastin-like polypeptide which occurs following a pH jump. We monitor the concentration of T = 3 and T = 1 capsids as a function of time and show that the time evolution of the conversion from one T number to another is not symmetric: the conversion from T = 1 to T = 3 is a factor of 10 slower than that of T = 3 to T = 1. We explain our experimental findings using a simple model based on classical nucleation theory applied to virus capsids, in which we account for the change in the free protein concentration, as the different types of shells assemble and disassemble by shedding or absorbing single protein subunits. As far as we are aware, this is the first study confirming that both the assembly and disassembly of viruslike shells can be explained through classical nucleation theory, reproducing quantitatively results from time-resolved experiments.

Published
2022
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116. Observation Scheduling and Automatic Data Reduction for the Antarctic telescope, ASTEP+

Author

Dransfield, Georgina, Mekarnia, Djamel, Triaud, Amaury H. M. J., Guillot, Tristan, Abe, Lyu, Garcia, Lionel J., Timmermans, Mathilde, Crouzet, Nicolas, Schmider, Francois-Xavier, Agabi, Abdelkrim, Suarez, Olga, Bendjoya, Philippe, Gunther, Maximilian N., Lai, Olivier, Merın, Bruno, and Stee, Philippe

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The possibility to observe transiting exoplanets from Dome C in Antarctica provides immense benefits: stable weather conditions, limited atmospheric turbulence, and a night that lasts almost three months due to the austral winter. However, this site also presents significant limitations, such as limited access for maintenance and internet speeds of only a few KB/s. This latter factor means that the approximately 6 TB of data collected annually must be processed on site automatically, with only final data products being sent once a day to Europe. In this context, we present the current state of operations of ASTEP+, a 40 cm optical telescope located at Concordia Station in Antarctica. Following a successful summer campaign, ASTEP+ has begun the 2022 observing season with a brand-new two-colour photometer with increased sensitivity. A new Python data analysis pipeline installed on a dedicated server in Concordia will significantly improve the precision of the extracted photometry, enabling us to get higher signal-to-noise transit detections. The new pipeline additionally incorporates automatic transit modelling to reduce the amount of manual post-processing required. It also handles the automatic daily transfer of the photometric lightcurves and control data to Europe. Additionally, we present the Python and web-based systems used for selection and scheduling of transit observations; these systems have wide applicability for the scheduling of other astronomical observations with strong time constraints. We also review the type of science that ASTEP+ will be conducting and analyse how unique ASTEP+ is to exoplanet transit research., Comment: Submitted to SPIE Proceedings

Published
2022

117. Cosmological implications of photon-flux upper limits at ultra-high energies in scenarios of Planckian-interacting massive particles for dark matter

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Vegas, A. L. Garcia, Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., and Aloisio, R.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

Using the data of the Pierre Auger Observatory, we report on a search for signatures that would be suggestive of super-heavy particles decaying in the Galactic halo. From the lack of signal, we present upper limits for different energy thresholds above ${\gtrsim}10^8$\,GeV on the secondary by-product fluxes expected from the decay of the particles. Assuming that the energy density of these super-heavy particles matches that of dark matter observed today, we translate the upper bounds on the particle fluxes into tight constraints on the couplings governing the decay process as a function of the particle mass. Instantons, which are non-perturbative solutions to Yang-Mills equations, can give rise to decay channels otherwise forbidden and transform stable particles into meta-stable ones. Assuming such instanton-induced decay processes, we derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X \lesssim 0.09$, for $10^{9} \lesssim M_X/\text{GeV} < 10^{19}$. Conversely, we obtain that, for instance, a reduced coupling constant $\alpha_X = 0.09$ excludes masses $M_X \gtrsim 3\times 10^{13}~$GeV. In the context of dark matter production from gravitational interactions alone during the reheating epoch, we derive constraints on the parameter space that involves, in addition to $M_X$ and $\alpha_X$, the Hubble rate at the end of inflation, the reheating efficiency, and the non-minimal coupling of the Higgs with curvature., Comment: 15 pages, 8 figures, Accompanying paper of arXiv:2203.08854, accepted for publication in Phys. Rev. D

Published
2022

118. Are Track Recommendations Dependent on Schools and School Boards? A Study of Trends in the Level of Track Recommendations, Number of Double Recommendations and Reconsiderations in Dutch Urban and Rural Areas

Author

Timmermans, A. C., Dijks, M. A., and Warrens, M. J.

Abstract

Track recommendations provided to students in the final grade of primary education lead the allocation to specific school tracks in secondary education in the Netherlands. Where the results of a standardised test indicate that students are able to go to a higher track level, primary schools are required to reconsider and potentially adjust the track recommendation to a higher level. The current research aimed to (1) investigate trends in the level of track recommendations, double track recommendations and reconsiderations over the years 2014-2015 to 2018-2019, (2) explore the variation in (trends of) track recommendations between Dutch primary schools and their school boards, and (3) assess the association between track recommendations and the school level variables degree of urbanisation and type of primary education. We used multilevel growth curve modelling for continuous and count data based on publicly available school-level population data regarding track recommendations and school leavers tests from 2014-2015 to 2018-2019. The number of double track recommendations has increased over the cohorts, with a slightly decreasing gap between schools in rural and urban areas. The number of reconsiderations first decreased and then increased. The differences in reconsiderations between rural and urban areas are increasing over time. An initial trend towards higher average recommendations stabilising in the later cohorts appeared with no clear pattern for degree of urbanisation. The current study adds to the existing knowledge by assessing longitudinal trends instead of cross-sectional analyses and including multiple stakeholders and factors simultaneously.

Published
2023
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119. Comparing Instructional Strategies to Support Student Teachers' Learning to Prepare an Open-Minded Citizenship Education Lesson

Author

van Brussel, Suzan, Timmermans, Miranda, Verkoeijen, Peter, and Paas, Fr

Abstract

Open-mindedness is defined as one's willingness and ability to consider opposing beliefs and perspectives and give them a serious, impartial consideration by setting aside one's commitment towards one's own beliefs and perspectives. Learning to prepare and teach open-minded lessons is a crucial skill for student teachers because it fosters an atmosphere in which pupils feel free to express their own views and to learn about the views of others. The aim of this experiment was to examine which instructional strategy best supports student teachers' learning to prepare an open-minded citizenship education lesson. Therefore, participants (n = 176) processed an instruction on how to prepare an open-minded citizenship education lesson through learning by teaching on video, preparing to teach, or re-study (control condition), and as a post-test designed a lesson plan. We examined the completeness and accuracy of the explanations of the instructional content, feelings of social presence and arousal, open-mindedness levels, the completeness and accuracy of the lesson plans, and the conceptual knowledge of the instructional content. In addition, the lesson plans were graded on overall quality. Results showed that all participants scored higher on open-mindedness as measured with the Actively Open-minded Thinking scale after the experiment than before the experiment. Participants in the control condition prepared significantly more accurate and complete open-minded lessons than participants in the other two conditions, suggesting they have gained better understanding of the instructional content. There were no significant differences between the conditions on the other outcome measures.

Published
2023
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122. Communicating the results of risk-based breast cancer screening through visualizations of risk: a participatory design approach

Author

Inge S. van Strien-Knippenberg, Hannah Arjangi-Babetti, Danielle R. M. Timmermans, Laura Schrauwen, Mirjam P. Fransen, Marijke Melles, and Olga C. Damman

Subjects
Risk communication, Risk visualizations, Risk-based screening, Cancer screening, Breast cancer, Educational material, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background Risk-based breast cancer (BC) screening raises new questions regarding information provision and risk communication. This study aimed to: 1) investigate women’s beliefs and knowledge (i.e., mental models) regarding BC risk and (risk-based) BC screening in view of implications for information development; 2) develop novel informational materials to communicate the screening result in risk-based BC screening, including risk visualizations of both quantitative and qualitative information, from a Human-Centered Design perspective. Methods Phase 1: Interviews were conducted (n = 15, 40–50 years, 5 lower health literate) on women’s beliefs about BC risk and (risk-based) BC screening. Phase 2: In three participatory design sessions, women (n = 4–6 across sessions, 40–50 years, 2–3 lower health literate) made assignments and created and evaluated visualizations of risk information central to the screening result. Prototypes were evaluated in two additional sessions (n = 2, 54–62 years, 0–1 lower health literate). Phase 3: Experts (n = 5) and women (n = 9, 40–74 years) evaluated the resulting materials. Two other experts were consulted throughout the development process to ensure that the content of the information materials was accurate. Interviews were transcribed literally and analysed using qualitative thematic analysis, focusing on implications for information development. Notes, assignments and materials from the participatory design sessions were summarized and main themes were identified. Results Women in both interviews and design sessions were positive about risk-based BC screening, especially because personal risk factors would be taken into account. However, they emphasized that the rationale of risk-based screening and classification into a risk category should be clearly stated and visualized, especially for higher- and lower-risk categories (which may cause anxiety or feelings of unfairness due to a lower screening frequency). Women wanted to know their personal risk, preferably visualized in an icon array, and wanted advice on risk reduction and breast self-examination. However, most risk factors were considered modifiable by women, and the risk factor breast density was not known, implying that information should emphasize that BC risk depends on multiple factors, including breast density. Conclusions The information materials, including risk visualizations of both quantitative and qualitative information, developed from a Human-Centered Design perspective and a mental model approach, were positively evaluated by the target group.

Published
2024
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123. Self-management support (SMS) in primary care practice: a qualitative focus group study of care professionals’ experiences

Author

Lotte Timmermans, Dagje Boeykens, Muhammed Mustafa Sirimsi, Dominique Van de Velde, Patricia De Vriendt, Peter Decat, Veerle Foulon, Ann Van Hecke, Mieke Vermandere, Birgitte Schoenmakers, and the Primary Care Academy

Subjects
Self-management support, Healthcare professionals, Primary health care, Qualitative research, Medicine (General), R5-920
Abstract

Abstract Background To support self-management of chronically ill persons, innovative approaches of care practice are being developed. Unfortunately, many self-management supporting interventions struggle to achieve reliable and consistent improvements at various levels (patient, provider and healthcare system level). One possible strategy to facilitate translating theory into practice, is to consider the healthcare professionals’ perspective prior to the development of new interventions. An exploration of their knowledge and opinion about barriers and facilitators is necessary before employing any self-management support (SMS) intervention. Therefore, our study aims to explore care professionals’ perspectives about SMS within the Flemish primary care setting. Methods This study used a qualitative study design to examine SMS in primary care setting. Five focus groups were conducted, grouped into three waves. Participants were healthcare professionals in Flanders representing different disciplines and settings. A maximum variation purposive sampling was used to recruit participants. For the data analysis, the framework of thematic networks by Attride-Stirling was applied. Results A total of 34 healthcare professionals participated. Three global themes related to SMS were derived from the thematic analysis: (1) Characteristics, (2) Support strategies, (3) Barriers and facilitators. SMS was characterised as a collaboration-based and person-centred approach. A variety of supporting strategies were mentioned by the focus group participants. Most strategies consisted of informing and educating patients. Complementary to individual strategies, collaborative strategies were deemed necessary to support self-management. Regarding barriers and facilitators, different patient-related factors were identified. Additionally, competencies of healthcare providers and external factors seem to hinder the implementation of SMS in practice. Conclusions This focus group study highlights the importance of a collaborative, person-centred approach to SMS in the context of chronic diseases. Our findings point to the need for interventions that raise awareness and address barriers associated with SMS. Since generic SMS does not exist, the road to success is a growth process in which support must be adapted to the individual patient.

Published
2024
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124. Hospital infections and health-related quality of life after cardiac surgery: a multicenter survey

Author

Hilda G. Rijnhart-de Jong, Jo Haenen, Fabiano Porta, Marijke Timmermans, E. Christiaan Boerma, Kim de Jong, and on behalf of the participating centers of the Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration

Subjects
Health-related quality of life, Cardiac surgery, Multicenter registry, Hospital infections, Physical recovery, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background Recent research suggested that hospital infections are a predictive marker for physical non-recovery one year after cardiothoracic surgery. The purpose of this study was to explore whether this risk factor is etiologic. Additional, the influence of a potential effect modifying factor, diabetes mellitus, was investigated. Methods In this multicenter study, patients underwent elective or urgent cardiothoracic surgery between 01-01-2015 and 31-12-2019, and completed pre- and one year post-operative Short Form Health Survey 36/12 quality of life questionnaires. A binary logistic regression model, in which the inverse of the propensity score for infection risk was included as a weight variable, was used. Second, this analysis was stratified for diabetes mellitus status. Results 8577 patients were included. After weighing for the propensity score, the standardized mean differences of all variables decreased and indicated sufficient balance between the infection and non-infection groups. Hospital infections were found to be a risk factor for non-recovery after cardiothoracic surgery in the original and imputed dataset before weighting. However, after propensity score weighing, hospital infections did not remain significantly associated with recovery (OR for recovery = 0.79; 95% CI [0.60–1.03]; p = 0.077). No significant interaction between diabetes mellitus and hospital infections on recovery was found (p = 0.845). Conclusions This study could not convincingly establish hospital infections as an etiologic risk factor for non-improvement of physical recovery in patients who underwent cardiothoracic surgery. In addition, there was no differential effect of hospital infections on non-improvement of physical recovery for patients with and without diabetes mellitus. Trial registration International Clinical Trials Registry Platform ID NL9818; date of registration, 22-10-2021 ( https://trialsearch.who.int/ ).

Published
2024
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125. Arrival Directions of Cosmic Rays above 32 EeV from Phase One of the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

A promising energy range to look for angular correlation between cosmic rays of extragalactic origin and their sources is at the highest energies, above few tens of EeV ($1\:{\rm EeV}\equiv 10^{18}\:$eV). Despite the flux of these particles being extremely low, the area of ${\sim}\:3{,}000 \: \text{km}^2$ covered at the Pierre Auger Observatory, and the 17-year data-taking period of the Phase 1 of its operations, have enabled us to measure the arrival directions of more than 2,600 ultra-high energy cosmic rays above $32\:\text{EeV}$. We publish this data set, the largest available at such energies from an integrated exposure of $122{,}000 \: \text{km}^2\:\text{sr}\:\text{yr}$, and search it for anisotropies over the $3.4\pi$ steradians covered with the Observatory. Evidence for a deviation in excess of isotropy at intermediate angular scale, with ${\sim}\:15^\circ$ Gaussian spread or ${\sim}\:25^\circ$ top-hat radius, is obtained at the $4\:\sigma$ significance level for cosmic-ray energies above ${\sim}\:40\:\text{EeV}$., Comment: Published version, 33 pages, 10 figures. Dataset and analysis software available at https://doi.org/10.5281/zenodo.6504276

Published
2022
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126. Investigating Hadronic Interactions at Ultra-High Energies with the Pierre Auger Observatory

Author

Goos, Isabel, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Vegas, A. L. Garcia, Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

The development of an extensive air shower depends not only on the nature of the primary ultra-high-energy cosmic ray but also on the properties of the hadronic interactions. For energies above those achievable in human-made accelerators, hadronic interactions are only accessible through the studies of extensive air showers, which can be measured at the Pierre Auger Observatory. With its hybrid detector design, the Pierre Auger Observatory measures both the longitudinal development of showers in the atmosphere and the lateral distribution of particles that arrive at the ground. This way, observables that are sensitive to hadronic interactions at ultra-high energies can be obtained. While the hadronic interaction cross-section can be assessed from the longitudinal profiles, the number of muons and their fluctuations measured with the ground detectors are linked to other physical properties. In addition to these direct studies, we discuss here how measurements of the atmospheric depth of the maximum of air-shower profiles and the characteristics of the muon signal at the ground can be used to test the self-consistency of the post-LHC hadronic models., Comment: Proceedings of VHEPU 56th Rencontres de Moriond 2022

Published
2022

127. A search for photons with energies above $2{\times}10^{17}$ eV using hybrid data from the low-energy extensions of the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Vegas, A. L. Garcia, Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Ultra-high-energy photons with energies exceeding $10^{17}$ eV offer a wealth of connections to different aspects of cosmic-ray astrophysics as well as to gamma-ray and neutrino astronomy. The recent observations of photons with energies in the $10^{15}$ eV range further motivate searches for even higher-energy photons. In this paper, we present a search for photons with energies exceeding $2{\times}10^{17}$ eV using about 5.5 years of hybrid data from the low-energy extensions of the Pierre Auger Observatory. The upper limits on the integral photon flux derived here are the most stringent ones to date in the energy region between $10^{17}$ and $10^{18}$ eV., Comment: Accepted for publication in ApJ

Published
2022
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128. Double-hit separation and dE/dx resolution of a time projection chamber with GEM readout

Author

Aoki, Yumi, Attié, David, Behnke, Ties, Bellerive, Alain, Bezshyyko, Oleg, Sankar, Deb Bhattacharya, Bhattacharya, Purba, Bhattacharya, Sudeb, Chang, Yue, Colas, Paul, De Lentdecker, Gilles, Dehmelt, Klaus, Desch, Klaus, Diener, Ralf, Dixit, Madhu, Einhaus, Ulrich, Fedorchuk, Oleksiy, Fleck, Ivor, Fujii, Keisuke, Fusayasu, Takahiro, Ganjour, Serguei, Gros, Philippe, Hayman, Peter, Ikematsu, Katsumasa, Jönsson, Leif, Kaminski, Jochen, Kato, Yukihiro, Kleinwort, Claus, Martin, Peter Kluit, Kobayashi, Makoto, Krämer, Uwe, Lundberg, Björn, Lupberger, Michael, Majumdar, Nayana, Malek, Paul, Matsuda, Takeshi, Mjoernmark, Ulf, Mukhopadhyay, Supratik, Müller, Felix, Münnich, Astrid, Nakajima, Jurina, Narita, Shinya, Negishi, Kentaro, Ogawa, Tomohisa, Oskarsson, Anders, Österman, Lennart, Peterson, Daniel, Qi, Huirong, Riallot, Marc, Rosemann, Christoph, Roth, Stefan, Schade, Peter, Schaefer, Oliver, Settles, Ronald Dean, Shirazi, Amir Noori, Shoji, Aiko, Smirnova, Oxana, Sugiyama, Akira, Takahashi, Tohru, Timmermans, Jan, Titov, Maksym, Tsionou, Dimitra, Vauth, Annika, Watanabe, Takashi, Werthenbach, Ulrich, Wu, Mengqing, Yang, Yifan, Yonamine, Ryo, Yuan, Zhiyang, Yumino, Keita, and Zhang, Fan

Subjects
Physics - Instrumentation and Detectors
Abstract

A time projection chamber (TPC) with micropattern gaseous detector (MPGD) readout is investigated as main tracking device of the International Large Detector (ILD) concept at the planned International Linear Collider (ILC). A prototype TPC equipped with a triple gas electron multiplier (GEM) readout has been built and operated in an electron test beam. The TPC was placed in a 1 T solenoidal field at the DESY II Test Beam Facility, which provides an electron beam up to 6 GeV/c. The performance of the readout modules, in particular the spatial point resolution, is determined and compared to earlier tests. New studies are presented with first results on the separation of close-by tracks and the capability of the system to measure the specific energy loss dE/dx. This is complemented by a simulation study on the optimization of the readout granularity to improve particle identification by dE/dx., Comment: 29 pages, 30 figures, 6 tables. This is the Accepted Manuscript version of an article accepted for publication in Journal of Instrumentation. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1748-0221/17/11/P11027

Published
2022
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129. Ultra-High-Energy Cosmic Rays: The Intersection of the Cosmic and Energy Frontiers

Author

Coleman, A., Eser, J., Mayotte, E., Sarazin, F., Schröder, F. G., Soldin, D., Venters, T. M., Aloisio, R., Alvarez-Muñiz, J., Batista, R. Alves, Bergman, D., Bertaina, M., Caccianiga, L., Deligny, O., Dembinski, H. P., Denton, P. B., di Matteo, A., Globus, N., Glombitza, J., Golup, G., Haungs, A., Hörandel, J. R., Jaffe, T. R., Kelley, J. L., Krizmanic, J. F., Lu, L., Matthews, J. N., Mariş, I., Mussa, R., Oikonomou, F., Pierog, T., Santos, E., Tinyakov, P., Tsunesada, Y., Unger, M., Yushkov, A., Albrow, M. G., Anchordoqui, L. A., Andeen, K., Arnone, E., Barghini, D., Bechtol, E., Bellido, J. A., Casolino, M., Castellina, A., Cazon, L., Conceição, R., Cremonini, R., Dujmovic, H., Engel, R., Farrar, G., Fenu, F., Ferrarese, S., Fujii, T., Gardiol, D., Gritsevich, M., Homola, P., Huege, T., Kampert, K. -H., Kang, D., Kido, E., Klimov, P., Kotera, K., Kozelov, B., Leszczyńska, A., Madsen, J., Marcelli, L., Marisaldi, M., Martineau-Huynh, O., Mayotte, S., Mulrey, K., Murase, K., Muzio, M. S., Ogio, S., Olinto, A. V., Onel, Y., Paul, T., Piotrowski, L., Plum, M., Pont, B., Reininghaus, M., Riedel, B., Riehn, F., Roth, M., Sako, T., Schlüter, F., Shoemaker, D., Sidhu, J., Sidelnik, I., Timmermans, C., Tkachenko, O., Veberič, D., Verpoest, S., Verzi, V., Vícha, J., Winn, D., Zas, E., and Zotov, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The present white paper is submitted as part of the "Snowmass" process to help inform the long-term plans of the United States Department of Energy and the National Science Foundation for high-energy physics. It summarizes the science questions driving the Ultra-High-Energy Cosmic-Ray (UHECR) community and provides recommendations on the strategy to answer them in the next two decades., Comment: Prepared as a solicited white paper for the 2021 Snowmass process. To be published in the Journal of High Energy Astrophysics. v2: fixed typos in author list. v3: included all community feedback received by July 1st 2022 and added the list of endorsers. v4 is the post-reviewer preprint accepted to Astroparticle Physics vol. 149

Published
2022
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130. Lipopeptide-mediated Cas9 RNP delivery: A promising broad therapeutic strategy for safely removing deep-intronic variants in ABCA4

Author

Irene Vázquez-Domínguez, Mert Öktem, Florian A. Winkelaar, Thai Hoang Nguyen, Anita D.M. Hoogendoorn, Eleonora Roschi, Galuh D.N. Astuti, Raoul Timmermans, Nuria Suárez-Herrera, Ilaria Bruno, Albert Ruiz-Llombart, Joseph Brealey, Olivier G. de Jong, Rob W.J. Collin, Enrico Mastrobattista, and Alejandro Garanto

Subjects
MT: RNA/DNA Editing, peptide-mediated delivery, CRISPR-Cas9 genome editing, lipopeptide, intron removal, ABCA4 deep-intronic variants, Therapeutics. Pharmacology, RM1-950
Abstract

Deep-intronic (DI) variants represent approximately 10%–12% of disease-causing genetic defects in ABCA4-associated Stargardt disease (STGD1). Although many of these DI variants are amenable to antisense oligonucleotide-based splicing-modulation therapy, no treatment is currently available. These molecules are mostly variant specific, limiting their applicability to a broader patient population. In this study, we investigated the therapeutic potential of the CRISPR-Cas9 system combined with the amphipathic lipopeptide C18:1-LAH5 for intracellular delivery to correct splicing defects caused by different DI variants within the same intron. The combination of these components facilitated efficient editing of two target introns (introns 30 and 36) of ABCA4 in which several recurrent DI variants are found. The partial removal of these introns did not affect ABCA4 splicing or its expression levels when assessed in two different human cellular models: fibroblasts and induced pluripotent stem cell-derived photoreceptor precursor cells (PPCs). Furthermore, the DNA editing in STGD1 patient-derived PPCs led to a ∼50% reduction of the pseudoexon-containing transcripts resulting from the c.4539+2001G>A variant in intron 30. Overall, we provide proof-of-concept evidence of the use of C18:1-LAH5 as a delivery system for therapeutic genome editing for ABCA4-associated DI variants, offering new opportunities for clinical translation.

Published
2024
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131. Facilitating self-management support using the behaviour change wheel (BCW) to address healthcare professionals’ behaviour

Author

Lotte Timmermans, Peter Decat, Veerle Foulon, Ann Van Hecke, Mieke Vermandere, and Birgitte Schoenmakers

Subjects
Behaviour change wheel, COM-B model, Self-management support, Intervention, Theory and practice of education, LB5-3640
Abstract

Background: Supporting self-management in healthcare practice is essential to improve chronic patients’ daily life experiences. Primary care professionals play an indispensable role in this. Nevertheless, supporting self-management in practice comes with many challenges. The aim of this study is to identify determinants of professionals’ supportive behaviour and develop an intervention that facilitates self-management support in primary care practice, using these determinants as building blocks. Methods: To develop the intervention, the Behaviour Change Wheel (BCW) was used which involves eight steps in three stages: (1) Understanding the behaviour using the COM-B model, (2) Identifying intervention options, and (3) Identifying content and implementation options. The theoretical underpinnings for stage 1 included data from interviews, focus groups and brainstorm sessions, incorporated beforehand in a self-management support model. Subsequently, literature analysis, empirical research and expertise from the research group guided stages 2 and 3. Results: We found that changes in “psychological capability”, “physical opportunity”, “reflective motivation” and “automatic motivation” are required to optimize professionals’ behaviour towards self-management support. The two key intervention functions identified were “enablement” and “education”. Therefore, a blended learning trajectory that incorporated these interventional building blocks was developed, integrating specific behaviour change techniques (BCTs) including: (1) Information about social and environmental consequences, (2) Information about health consequences, and (3) Social support (practical). The learning design was finalized by applying the Absorb-Do-Connect learning framework developed by Horton. Conclusions: Application of the BCW framework shaped a self-management support intervention to educate and enable healthcare professionals. Future research will pilot and refine the intervention.

Published
2024
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132. Co-creation of a health literate-sensitive training and conversation aid to support shared decision-making in maternity care

Author

Laxsini Murugesu, Mirjam P. Fransen, Danielle R.M. Timmermans, Arwen H. Pieterse, Ellen M.A. Smets, and Olga C. Damman

Subjects
Shared decision-making, Maternity care, Health literacy, Co-creation, Training, Patient decision aids, Public aspects of medicine, RA1-1270
Abstract

Background: Maternity care increasingly aims to achieve Shared Decision-making (SDM), yet seemingly not to the benefit of clients with low health literacy (HL). We developed an SDM training for healthcare professionals (HCPs) and a conversation aid to support HL-sensitive SDM in maternity care. Methods: The training and conversation aid were based on previous needs assessments and expert consultation, and were developed in co-creation with clients (n = 15) and HCPs (n = 7). Usability, acceptability and comprehension of the conversation aid were tested among new clients (n = 14) and HCPs (n = 6). Acceptability of the training was tested among midwifery students (n = 5). Results: In the co-creation sessions, clients reported to expect that their midwife becomes acquainted with their general values, priorities and daily context. Clients also emphasized wanting to be supported in their preferred decisional role. User test interviews showed that clients and HCPs were positive towards using the conversation aid, but also apprehensive about the time it required. The user test of the training showed that more attention was needed for recognizing and adapting information provision to clients' HL level. Conclusion and innovation: The newly developed conversation aid and training have potential to support HCPs and clients in HL-sensitive SDM.

Published
2024
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133. Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Author

Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, and Karolien De Bosscher

Subjects
Nuclear receptor, Nuclear receptor crosstalk, PPARα, ERRα, Protein–protein interaction, PGC1α, Internal medicine, RC31-1245
Abstract

Objective: The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription factor is incompletely understood. An ORFeome-wide unbiased mammalian protein–protein interaction trap (MAPPIT) using PPARα as bait revealed a PPARα-ligand-dependent interaction with the orphan nuclear receptor estrogen-related receptor α (ERRα). The goal of this study was to characterize the nature of the interaction in depth and to explore whether it was of physiological relevance. Methods: We used orthogonal protein–protein interaction assays and pharmacological inhibitors of ERRα in various systems to confirm a functional interaction and study the impact of crosstalk mechanisms. To characterize the interaction surfaces and contact points we applied a random mutagenesis screen and structural overlays. We pinpointed the extent of reciprocal ligand effects of both nuclear receptors via coregulator peptide recruitment assays. On PPARα targets revealed from a genome-wide transcriptome analysis, we performed an ERRα chromatin immunoprecipitation analysis on both fast and fed mouse livers. Results: Random mutagenesis scanning of PPARα's ligand-binding domain and coregulator profiling experiments supported the involvement of (a) bridging coregulator(s), while recapitulation of the interaction in vitro indicated the possibility of a trimeric interaction with RXRα. The PPARα·ERRα interaction depends on 3 C-terminal residues within helix 12 of ERRα and is strengthened by both PGC1α and serum deprivation. Pharmacological inhibition of ERRα decreased the interaction of ERRα to ligand-activated PPARα and revealed a transcriptome in line with enhanced mRNA expression of prototypical PPARα target genes, suggesting a role for ERRα as a transcriptional repressor. Strikingly, on other PPARα targets, including the isolated PDK4 enhancer, ERRα behaved oppositely. Chromatin immunoprecipitation analyses demonstrate a PPARα ligand-dependent ERRα recruitment onto chromatin at PPARα-binding regions, which is lost following ERRα inhibition in fed mouse livers. Conclusions: Our data support the coexistence of multiple layers of transcriptional crosstalk mechanisms between PPARα and ERRα, which may serve to finetune the activity of PPARα as a nutrient-sensing transcription factor.

Published
2024
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134. Protocol for xenografting of BxPC-3 pancreatic tumors using a chorioallantoic membrane model

Author

Robin Colenbier, Lenny Coppens, Tine Logghe, Eke van Zwol, Jean-Pierre Timmermans, and Johannes Bogers

Subjects
Cell culture, Cancer, Model Organisms, Science (General), Q1-390
Abstract

Summary: The chorioallantoic membrane (CAM) model is an increasingly attractive model for the study of human tumors. However, concise techniques for the use of pancreatic ductal adenocarcinoma BxPC-3 xenografts in CAM assays are not yet available. Here, we present a protocol for the induction of BxPC-3 xenograft tumors with high grafting efficiency. We describe steps for embryo incubation, egg handling, and grafting, each of which has been optimized to prevent fungal contamination and minimize mortality. : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.

Published
2024
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135. The Role of Ocean Mesoscale Variability in Air‐Sea CO2 Exchange: A Global Perspective

Author

Yiming Guo and Mary‐Louise Timmermans

Subjects
Geophysics. Cosmic physics, QC801-809
Abstract

Abstract Ocean mesoscale flows significantly influence nutrient distribution and biological productivity, yet the scarcity of eddy‐permitting observational data sets and climate modeling hinders understanding their role in carbon sequestration. Using an eddy‐resolving global simulation, this study investigates the significance of ocean mesoscales in air‐sea carbon dioxide (CO2) exchange. Results show over 30% of CO2 flux variance in energetic regions attributed to flows with horizontal scales smaller than 2°. Mesoscale flows can drive a cumulative CO2 flux that is either a net carbon sink or source depending on region, with magnitudes on the order of 105 tonnes of carbon per year. Variations in this mesoscale‐related CO2 flux are correlated with local relative vorticity and the background gradient of ocean partial pressure of CO2. This analysis underscores the importance of considering ocean mesoscales in monitoring carbon flux, highlighting the need to explore the influence of increasing eddy activity on carbon uptake in a changing climate.

Published
2024
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136. GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment

Author

Bircan Coban, Zi Wang, Chen-yi Liao, Klara Beslmüller, Mieke A.M. Timmermans, John W.M. Martens, Jasmijn H.M. Hundscheid, Bram Slutter, Annelien J.M. Zweemer, Elsa Neubert, and Erik H.J. Danen

Subjects
Molecular biology, Immunology, Cell biology, Cancer, Science
Abstract

Summary: Tumor tissues often contain high extracellular adenosine, promoting an immunosuppressed environment linked to mesenchymal transition and immune evasion. Here, we show that loss of the epithelial transcription factor, GRHL2, triggers NT5E/CD73 ecto-enzyme expression, augmenting the conversion of AMP to adenosine. GRHL2 binds an intronic NT5E sequence and is negatively correlated with NT5E/CD73 in breast cancer cell lines and patients. Remarkably, the increased adenosine levels triggered by GRHL2 depletion in MCF-7 breast cancer cells do not suppress but mildly increase CD8 T cell recruitment, a response mimicked by a stable adenosine analog but prevented by CD73 inhibition. Indeed, NT5E expression shows a positive rather than negative association with CD8 T cell infiltration in breast cancer patients. These findings reveal a GRHL2-regulated immune modulation mechanism in breast cancers and show that extracellular adenosine, besides its established role as a suppressor of T cell-mediated cytotoxicity, is associated with enhanced T cell recruitment.

Published
2024
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138. A Study of Flares in the Ultra-Cool Regime from SPECULOOS-South

Author

Murray, C. A., Queloz, D., Gillon, M., Demory, B. O., Triaud, A. H. M. J., de Wit, J., Burdanov, A., Chinchilla, P., Delrez, L., Dransfield, G., Ducrot, E., Garcia, L. J., Chew, Y. Gómez Maqueo, Günther, M. N., Jehin, E., McCormac, J., Niraula, P., Pedersen, P. P., Pozuelos, F. J., Rackham, B. V., Schanche, N., Sebastian, D., Thompson, S. J., Timmermans, M., and Wells, R.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

We present a study of photometric flares on 154 low-mass ($\leq 0.2 \textrm{M}_{\odot}$) objects observed by the SPECULOOS-South Observatory from 1st June 2018 to 23rd March 2020. In this sample we identify 85 flaring objects, ranging in spectral type from M4 to L0. We detect 234 flares in this sample, with energies between $10^{29.2}$ and $10^{32.7}$ erg, using both automated and manual methods. With this work, we present the largest photometric sample of flares on late-M and ultra-cool dwarfs to date. By extending previous M dwarf flare studies into the ultra-cool regime, we find M5-M7 stars are more likely to flare than both earlier, and later, M dwarfs. By performing artificial flare injection-recovery tests we demonstrate that we can detect a significant proportion of flares down to an amplitude of 1 per cent, and we are most sensitive to flares on the coolest stars. Our results reveal an absence of high-energy flares on the reddest dwarfs. To probe the relations between rotation and activity for fully convective stars, we extract rotation periods for fast rotators and lower-bound period estimates of slow rotators. These rotation periods span from 2.2 hours to 65 days, and we find that the proportion of flaring stars increases for the very fastest rotators. Finally, we discuss the impact of our flare sample on planets orbiting ultra-cool stars. As stars become cooler, they flare less frequently; therefore, it is unlikely that planets around the very reddest dwarfs would enter the `abiogenesis' zone or drive visible-light photosynthesis through flares alone., Comment: 21 pages, 12 figures, to be published in MNRAS

Published
2022
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139. Limits to gauge coupling in the dark sector set by the non-observation of instanton-induced decay of Super-Heavy Dark Matter in the Pierre Auger Observatory data

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Vegas, A. L. Garcia, Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., and Aloisio, R.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

Instantons, which are non-perturbative solutions to Yang-Mills equations, provide a signal for the occurrence of quantum tunneling between distinct classes of vacua. They can give rise to decays of particles otherwise forbidden. Using data collected at the Pierre Auger Observatory, we search for signatures of such instanton-induced processes that would be suggestive of super-heavy particles decaying in the Galactic halo. These particles could have been produced during the post-inflationary epoch and match the relic abundance of dark matter inferred today. The non-observation of the signatures searched for allows us to derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X \lesssim 0.09$, for $10^{9} \lesssim M_X/{\rm GeV} < 10^{19}$. Conversely, we obtain that, for instance, a reduced coupling constant $\alpha_X = 0.09$ excludes masses $M_X \gtrsim 3\times 10^{13}~$GeV. In the context of dark matter production from gravitational interactions alone, we illustrate how these bounds are complementary to those obtained on the Hubble rate at the end of inflation from the non-observation of tensor modes in the cosmological microwave background., Comment: 9 pages, 3 figures, accepted for publication in Phys. Rev. Lett

Published
2022
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140. Electric dipole moments and the search for new physics

Author

Alarcon, Ricardo, Alexander, Jim, Anastassopoulos, Vassilis, Aoki, Takatoshi, Baartman, Rick, Baeßler, Stefan, Bartoszek, Larry, Beck, Douglas H., Bedeschi, Franco, Berger, Robert, Berz, Martin, Bethlem, Hendrick L., Bhattacharya, Tanmoy, Blaskiewicz, Michael, Blum, Thomas, Bowcock, Themis, Borschevsky, Anastasia, Brown, Kevin, Budker, Dmitry, Burdin, Sergey, Casey, Brendan C., Casse, Gianluigi, Cantatore, Giovanni, Cheng, Lan, Chupp, Timothy, Cianciolo, Vince, Cirigliano, Vincenzo, Clayton, Steven M., Crawford, Chris, Das, B. P., Davoudiasl, Hooman, de Vries, Jordy, DeMille, David, Denisov, Dmitri, Diwan, Milind V., Doyle, John M., Engel, Jonathan, Fanourakis, George, Fatemi, Renee, Filippone, Bradley W., Flambaum, Victor V., Fleig, Timo, Fomin, Nadia, Fischer, Wolfram, Gabrielse, Gerald, Ruiz, R. F. Garcia, Gardikiotis, Antonios, Gatti, Claudio, Geraci, Andrew, Gooding, James, Golub, Bob, Graham, Peter, Gray, Frederick, Griffith, W. Clark, Haciomeroglu, Selcuk, Gwinner, Gerald, Hoekstra, Steven, Hoffstaetter, Georg H., Huang, Haixin, Hutzler, Nicholas R., Incagli, Marco, Ito, Takeyasu M., Izubuchi, Taku, Jayich, Andrew M., Jeong, Hoyong, Kaplan, David, Karuza, Marin, Kawall, David, Kim, On, Koop, Ivan, Korsch, Wolfgang, Korobkina, Ekaterina, Lebedev, Valeri, Lee, Jonathan, Lee, Soohyung, Lehnert, Ralf, Leung, Kent K. H., Liu, Chen-Yu, Long, Joshua, Lusiani, Alberto, Marciano, William J., Maroudas, Marios, Matlashov, Andrei, Matsumoto, Nobuyuki, Mawhorter, Richard, Meot, Francois, Mereghetti, Emanuele, Miller, James P., Morse, William M., Mott, James, Omarov, Zhanibek, Orozco, Luis A., O'Shaughnessy, Christopher M., Ozben, Cenap, Park, SeongTae, Pattie Jr., Robert W., Petrov, Alexander N., Piacentino, Giovanni Maria, Plaster, Bradley R., Podobedov, Boris, Poelker, Matthew, Pocanic, Dinko, Prasannaa, V. S., Price, Joe, Ramsey-Musolf, Michael J., Raparia, Deepak, Rajendran, Surjeet, Reece, Matthew, Reid, Austin, Rescia, Sergio, Ritz, Adam, Roberts, B. Lee, Safronova, Marianna S., Sakemi, Yasuhiro, Schmidt-Wellenburg, Philipp, Shindler, Andrea, Semertzidis, Yannis K., Silenko, Alexander, Singh, Jaideep T., Skripnikov, Leonid V., Soni, Amarjit, Stephenson, Edward, Suleiman, Riad, Sunaga, Ayaki, Syphers, Michael, Syritsyn, Sergey, Tarbutt, M. R., Thoerngren, Pia, Timmermans, Rob G. E., Tishchenko, Volodya, Titov, Anatoly V., Tsoupas, Nikolaos, Tzamarias, Spyros, Variola, Alessandro, Venanzoni, Graziano, Vilella, Eva, Vossebeld, Joost, Winter, Peter, Won, Eunil, Zelenski, Anatoli, Zelevinsky, Tanya, Zhou, Yan, and Zioutas, Konstantin

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, High Energy Physics - Lattice, Nuclear Experiment, Nuclear Theory
Abstract

Static electric dipole moments of nondegenerate systems probe mass scales for physics beyond the Standard Model well beyond those reached directly at high energy colliders. Discrimination between different physics models, however, requires complementary searches in atomic-molecular-and-optical, nuclear and particle physics. In this report, we discuss the current status and prospects in the near future for a compelling suite of such experiments, along with developments needed in the encompassing theoretical framework., Comment: Contribution to Snowmass 2021; updated with community edits and endorsements

Published
2022

141. The International Linear Collider: Report to Snowmass 2021

Author

Aryshev, Alexander, Behnke, Ties, Berggren, Mikael, Brau, James, Craig, Nathaniel, Freitas, Ayres, Gaede, Frank, Gessner, Spencer, Gori, Stefania, Grojean, Christophe, Heinemeyer, Sven, Jeans, Daniel, Kruger, Katja, List, Benno, List, Jenny, Liu, Zhen, Michizono, Shinichiro, Miller, David W., Moult, Ian, Murayama, Hitoshi, Nakada, Tatsuya, Nanni, Emilio, Nojiri, Mihoko, Padamsee, Hasan, Perelstein, Maxim, Peskin, Michael E., Poeschl, Roman, Posen, Sam, Robson, Aidan, Strube, Jan, Suehara, Taikan, Tian, Junping, Titov, Maxim, Vos, Marcel, White, Andrew, Wilson, Graham, Yokoya, Kaoru, Zarnecki, Aleksander Filip, Adachi, Ichiro, Agashe, Kaustubh, Jovin, Tatjana Agatonovic, Aihara, Hiroaki, Altmannshofer, Wolfgang, Alves, Daniele, Anguiano, Justin, Aoki, Ken-Ichi, Aoki, Masato, Aoki, Toshihiro, Aoki, Yumi, Arai, Yasuo, Araki, Hayato, Asada, Haruka, Asai, Kento, Asai, Shoji, Attie, David, Baer, Howard, Bagger, Jonathan, Bai, Yang, Bailey, Ian, Barrue, Ricardo, Bartoldus, Rainer, Barzi, Emanuela, Basso, Matthew, Bauerdick, Lothar, Baum, Sebastian, Bellerive, Alain, Belomestnykh, Sergey, Antequera, Jorge Berenguer, Beyer, Jakob, Bhat, Pushpalatha, Bilki, Burak, Black, Kevin, Bloom, Kenneth, Bodwin, Geoffrey, Boisvert, Veronique, Boran, Fatma, Boudry, Vincent, Boughezal, Radja, Boveia, Antonio, Bozovic-Jelisavcic, Ivanka, Brient, Jean-Claude, Brodsky, Stanley, Brunetti, Laurent, Buesser, Karsten, Bulyak, Eugene, Burrows, Philip N., Burt, Graeme C., Cai, Yunhai, Cairo, Valentina, Canepa, Anadi, Celiberto, Francesco Giovanni, Cenni, Enrico, Chacko, Zackaria, Chaikovska, Iryna, Checchin, Mattia, Chen, Lisong, Chen, Thomas Y., Cheng, Hsin Chia, Cho, Gi-Chol, Choudhary, Brajesh, Clarke, Jim, Cline, James, Co, Raymond, Cohen, Timothy, Colas, Paul, Damerell, Chris, Das, Arindam, Dasu, Sridhara, Dawson, Sally, de Blas, Jorge, de Lima, Carlos Henrique, Deandrea, Aldo, Dehmelt, Klaus, Delayen, Jean, Demarteau, Marcel, Denisov, Dmitri, Dermisek, Radovan, Dieguez, Angel, Dohmae, Takeshi, Dopke, Jens, Dort, Katharina, Du, Yong, Dudar, Bohdan, Dutta, Bhaskar, Dutta, Juhi, Einhaus, Ulrich, Elsen, Eckhard, Endo, Motoi, Eremeev, Grigory, Eren, Engin, Erler, Jens, Esarey, Eric, Everett, Lisa, Golfe, Angeles Faus, Garcia, Marcos Fernandez, Foster, Brian, Fourches, Nicolas, Fouz, Mary-Cruz, Fujii, Keisuke, Fujimoto, Junpei, Torregrosa, Esteban Fullan, Furukawa, Kazuro, Fusayasu, Takahiro, Fuster, Juan, Ganjour, Serguei, Gao, Yuanning, Gaur, Naveen, Geng, Rongli, Georgi, Howard, Gherghetta, Tony, Goldstein, Joel, Goncalves, Dorival, Gonski, Julia, Gonzalo, Tomas, Goto, Takeyoshi, Goto, Toru, Graf, Norman, Grames, Joseph, Grannis, Paul, Gray, Lindsey, Grohsjean, Alexander, Gu, Jiayin, Guler, Yalcin, Gutierrez, Phillip, Haba, Junji, Haber, Howard, Hallford, John, Hamaguchi, Koichi, Han, Tao, Hara, Kazuhiko, Harada, Daisuke, Hashimoto, Koji, Hashino, Katsuya, Hayashi, Masahito, Heinrich, Gudrun, Hidaka, Keisho, Higuchi, Takeo, Hinode, Fujio, Hioki, Zenro, Hirose, Minoru, Hiroshima, Nagisa, Hisano, Junji, Hollik, Wolfgang, Homiller, Samuel, Hong, Sungwoo, Hook, Anson, Horii, Yasuyuki, Hoshina, Hiroki, Hristova, Ivana, Huitu, Katri, Hyakutake, Yoshifumi, Iijima, Toru, Ikematsu, Katsumasa, Ilderton, Anton, Inami, Kenji, Irles, Adrian, Ishikawa, Akimasa, Ishiwata, Koji, Ito, Hayato, Ivanov, Igor, Iwamoto, Sho, Iwamoto, Toshiyuki, Iwasaki, Masako, Iwashita, Yoshihisa, Jia, Haoyi, Morales, Fabricio Jimenez, Joshi, Prakash, Jung, Sunghoon, Kacarevic, Goran, Kagan, Michael, Kakizaki, Mitsuru, Kalinowski, Jan, Kaminski, Jochen, Kanaya, Kazuyuki, Kanemura, Shinya, Kanno, Hayato, Kano, Yuya, Kashiwagi, Shigeru, Kato, Yukihiro, Kawada, Nanami, Kawada, Shin-ichi, Kawagoe, Kiyotomo, Khoze, Valery, Kichimi, Hiromichi, Kim, Doojin, Kitahara, Teppei, Kitano, Ryuichiro, Klamka, Jan, Komamiya, Sachio, Kong, K. C., Konomi, Taro, Kotera, Katsushige, Kou, Emi, Kravchenko, Ilya, Kubo, Kiyoshi, Kubo, Takayuki, Kumaoka, Takuya, Kumar, Ashish, Kumar, Nilanjana, Kunath, Jonas, Kundu, Saumyen, Kunitomo, Hiroshi, Kurata, Masakazu, Kuriki, Masao, Kusenko, Alexander, Lagouri, Theodota, Lankford, Andrew J., Lastovicka-Medin, Gordana, Diberder, Francois Le, Lee, Claire, Liepe, Matthias, Linacre, Jacob, Liptak, Zachary, Lomte, Shivani, Low, Ian, Ma, Yang, Maalouf, Hani, MacFarlane, David, Madison, Brendon, Madlener, Thomas, Maeda, Tomohito, Malek, Paul, Mandal, Sanjoy, Markiewicz, Thomas, Marshall, John, Martens, Aurelien, Martin, Victoria, Martinello, Martina, Rivero, Celso Martinez, Maru, Nobuhito, Matheson, John, Matsumoto, Shigeki, Matsunaga, Hiroyuki, Matsuo, Yutaka, Mawatari, Kentarou, Mbagwu, Johnpaul, McIntosh, Peter, McKeown, Peter, Meade, Patrick, Mekala, Krzysztof, Merkel, Petra, Mihara, Satoshi, Miralles, Víctor, Lopez, Marcos Miralles, Mishima, Go, Mishima, Satoshi, Mistlberger, Bernhard, Mitov, Alexander, Miyabayashi, Kenkichi, Miyamoto, Akiya, Mohanty, Gagan, Monaco, Laura, Mondragon, Myriam, Montgomery, Hugh E., Moortgat-Pick, Gudrid, Morange, Nicolas, Llacer, María Moreno, Moretti, Stefano, Mori, Toshinori, Morii, Toshiyuki, Moroi, Takeo, Morrissey, David, Nachman, Benjamin, Nagano, Kunihiro, Nakajima, Jurina, Nakamura, Eiji, Narita, Shinya, Nath, Pran, Nelson, Timothy, Newbold, David, Niki, Atsuya, Nishimura, Yasuhiro, Nishiyama, Eisaku, Nomura, Yasunori, Nowak, Kacper, Nozaki, Mitsuaki, de Vera, María Teresa Nunez Pardo, Ochoa, Ines, Ogata, Masahito, Ohashi, Satoru, Ohta, Hikaru, Ohta, Shigemi, Ohuchi, Norihito, Oide, Hideyuki, Okada, Nobuchika, Okada, Yasuhiro, Okawa, Shohei, Okayasu, Yuichi, Okugawa, Yuichi, Okugi, Toshiyuki, Okui, Takemichi, Okuyama, Yoshitaka, Omet, Mathieu, Omori, Tsunehiko, Ono, Hiroaki, Onoe, Tomoki, Ootani, Wataru, Otono, Hidetoshi, Ozawa, Shuhei, Griso, Simone Pagan, Papa, Alessandro, Paparella, Rocco, Park, Eun-Kyung, Perez, Gilad, Perez-Lorenzana, Abdel, Peters, Yvonne, Petriello, Frank, Piedra, Jonatan, Porod, Werner, Potter, Christopher, Price, Alan, Radkhorrami, Yasser, Reina, Laura, Reuter, Juergen, Richard, Francois, Riemann, Sabine, Rimmer, Robert, Rizzo, Thomas, Robens, Tania, Ruber, Roger, Jimeno, Alberto Ruiz, Saeki, Takayuki, Saha, Ipsita, Saito, Tomoyuki, Sakaguchi, Makoto, Sakai, Tadakatsu, Sakaki, Yasuhito, Sakurai, Kodai, Salvatico, Riccardo, Salvatore, Fabrizio, San, Yik Chuen, Sandick, Pearl, Sanuki, Tomoyuki, Sasikumar, Kollassery Swathi, Schaefer, Oliver, Schaefer, Ruth, Schneekloth, Uwe, Schoerner-Sadenius, Thomas, Schroeder, Carl, Schuster, Philip, Schwartzman, Ariel, Schwienhorst, Reinhard, Sefkow, Felix, Seiya, Yoshihiro, Sekiguchi, Motoo, Sekizawa, Kazuyuki, Senyo, Katsumi, Sert, Hale, Sertore, Danielev, Settles, Ronald, Shafi, Qaisar, Shahdara, Tetsuo, Haghi, Barmak Shams Es, Sharma, Ashish, Shelton, Jessie, Shepherd-Themistocleous, Claire, Shibuya, Hiroto, Shidara, Tetsuo, Shimomura, Takashi, Shindou, Tetsuo, Shoji, Yutaro, Shu, Jing, Sievers, Ian, Simon, Frank, Singh, Rajeev, Soreq, Yotam, Stanitzki, Marcel, Stapnes, Steinar, Steinhebel, Amanda, Stupak, John, Su, Shufang, Suekane, Fumihiko, Sugamoto, Akio, Sugawara, Yuji, Sugimoto, Satoru, Sugimoto, Yasuhiro, Sugiyama, Hiroaki, Sumino, Yukinari, Sundrum, Raman, Suzuki, Atsuto, Suzuki, Shin, Swiatlowski, Maximilian, Tait, Tim M. P., Takahashi, Shota, Takahashi, Tohru, Takeshita, Tohru, Takeuchi, Michihisa, Takubo, Yosuke, Tanabe, Tomohiko, Tanedo, Philip, Tanimoto, Morimitsu, Tao, Shuichiro, Tata, Xerxes, Tauchi, Toshiaki, Taylor, Geoffrey, Terada, Takahiro, Terunuma, Nobuhiro, Thaler, Jesse, Thea, Alessandro, Tillinger, Finn, Timmermans, Jan, Tobioka, Kohsaku, Toda, Kouichi, Tokiyasu, Atsushi, Toma, Takashi, Torndal, Julie, Tosun, Mehmet, Tsai, Yu-Dai, Tseng, Shih-Yen, Tsumura, Koji, Tuckler, Douglas, Uchida, Yoshiki, Uchiyama, Yusuke, Ueda, Daiki, Ukegawa, Fumihiko, Umemori, Kensei, Urakawa, Junji, Vallee, Claude, Vega, Roberto, Velasco, Liliana, Verdu-Andres, Silvia, Vernieri, Caterina, Vila, Anna, Alvarez, Ivan Vila, Vossebeld, Joost, Vsrms, Raghava, Vukasinovic, Natasa, Wackeroth, Doreen, Wakida, Moe, Wang, Liantao, Washio, Masakazu, Watanabe, Takashi, Watson, Nigel, Watts, Gordon, Weiglein, Georg, Wells, James D., Wenskat, Marc, Westhoff, Susanne, White, Glen, Williams, Ciaran, Willocq, Stephane, Wing, Matthew, Winter, Alasdair, Winter, Marc, Wu, Yongcheng, Xie, Keping, Xu, Tao, Yakovlev, Vyacheslav, Yamada, Shuei, Yamamoto, Akira, Yamamoto, Hitoshi, Yamamoto, Kei, Yamamoto, Yasuchika, Yamanaka, Masato, Yamashita, Satoru, Yamatani, Masahiro, Yamatsu, Naoki, Yasui, Shigehiro, Yoda, Takuya, Yonamine, Ryo, Yoshihara, Keisuke, Yoshioka, Masakazu, Yoshioka, Tamaki, Yuasa, Fukuko, Yumino, Keita, Zerwas, Dirk, Zheng, Ya-Juan, Zhou, Jia, Zhu, Hua Xing, Zobov, Mikhail, and Zomer, Fabian

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community., Comment: 356 pages, Large pdf file (40 MB) submitted to Snowmass 2021; v2 references to Snowmass contributions added, additional authors; v3 references added, some updates, additional authors

Published
2022

142. Renormalization of One-Pion Exchange in Chiral Effective Field Theory for Antinucleon-Nucleon Scattering

Author

Zhou, Daren, Long, Bingwei, Timmermans, R. G. E., and van Kolck, U.

Subjects
Nuclear Theory, High Energy Physics - Phenomenology
Abstract

The renormalization of iterated one-pion exchange (OPE) is studied in Chiral Effective Field Theory ($\chi$EFT) for the antinucleon-nucleon ($\overline{N}\!N$) system. The OPE potential is cut off at a certain distance and contact interactions are represented by a complex spherical well with the same radius. We investigate the dependence on the cutoff radius of the phase shifts, inelasticities, and mixing angles for the low partial waves in $\overline{N}\!N$ scattering. We show that renormalization requires additional contact interactions compared to the expectation based on naive dimensional analysis. Results after renormalization are compared with the state-of-the-art energy-dependent partial-wave analysis of $\overline{N}\!N$ data. We compare our conclusions with applications of $\chi$EFT to the nucleon-nucleon system., Comment: 33 pages, 22 figures and 3 tables

Published
2022
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143. MPGDs for TPCs at future lepton colliders

Author

Bellerive, Alain, Kaminski, Jochen, Lewis, Peter M., Colas, Paul, Diener, Ralf, Kluit, Peter, Settles, Ronald Dean, Timmermans, Jan, Titov, Maxim, Centeno, Andreas Loschcke, Wessel, Christian, Hartbrich, Oskar, Vahsen, Sven, Marinas, Carlos, Qi, Huiron, and Zhang, Zhiyong

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This submission will focus on advancements and advantages of Micro Pattern Gas Detector (MPGD) technologies and their applications to the construction of a dedicated Time Projection Chamber (TPC) that can serve as an excellent main tracker for any multipurpose detector that can be foreseen to operate at a future lepton collider. The first portion of the report will be the executive summary. It will be followed by sections detailing the applications of MPGDs specifically to the construction of the LCTPC for the ILD at ILC, for a possible upgrade of the Belle II detector at SuperKEKB and for the design of a TPC for a detector at CEPC. MPGD technologies offer synergies with other detector R&D and several application domains; a few examples will be provided in the context of the ongoing Snowmass long range planning exercise in the USA. Links to industrial partnership and work with institutions in the USA will be highlighted when appropriate., Comment: Contribution to Snowmass 2021. And on behalf of the LCTPC Collaboration

Published
2022

144. TESS discovery of a sub-Neptune orbiting a mid-M dwarf TOI-2136

Author

Gan, Tianjun, Soubkiou, Abderahmane, Wang, Sharon X., Benkhaldoun, Zouhair, Mao, Shude, Artigau, Étienne, Fouqué, Pascal, Giacalone, Steven, Theissen, Christopher A., Aganze, Christian, Collins, Karen A., Shporer, Avi, Barkaoui, Khalid, Ghachoui, Mourad, Howell, Steve B., Lamman, Claire, Demangeon, Olivier D. S., Burdanov, Artem, Cadieux, Charles, Chouqar, Jamila, Collins, Kevin I., Cook, Neil J., Delrez, Laetitia, Demory, Brice-Olivier, Doyon, René, Dransfield, Georgina, Dressing, Courtney D., Ducrot, Elsa, Fan, Jiahao, Garcia, Lionel, Gill, Holden, Gillon, Michaël, Gnilka, Crystal L., Chew, Yilen Gómez Maqueo, Günther, Maximilian N., Henze, Christopher E., Huang, Chelsea X., Jehin, Emmanuel, Jensen, Eric L. N., Lin, Zitao, McCormac, James, Murray, Catriona A., Niraula, Prajwal, Pedersen, Peter P., Pozuelos, Francisco J., Queloz, Didier, Rackham, Benjamin V., Savel, Arjun B., Schanche, Nicole, Schwarz, Richard P., Sebastian, Daniel, Thompson, Samantha, Timmermans, Mathilde, Triaud, Amaury H. M. J., Vezie, Michael, Wells, Robert D., de Wit, Julien, Ricker, George R., Vanderspek, Roland, Latham, David W., Seager, Sara, Winn, Joshua N., and Jenkins, Jon M.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present the discovery of TOI-2136b, a sub-Neptune planet transiting every 7.85 days a nearby M4.5V-type star, identified through photometric measurements from the TESS mission. The host star is located $33$ pc away with a radius of $R_{\ast} = 0.34\pm0.02\ R_{\odot}$, a mass of $0.34\pm0.02\ M_{\odot}$ and an effective temperature of $\rm 3342\pm100\ K$. We estimate its stellar rotation period to be $75\pm5$ days based on archival long-term photometry. We confirm and characterize the planet based on a series of ground-based multi-wavelength photometry, high-angular-resolution imaging observations, and precise radial velocities from CFHT/SPIRou. Our joint analysis reveals that the planet has a radius of $2.19\pm0.17\ R_{\oplus}$, and a mass measurement of $6.4\pm2.4\ M_{\oplus}$. The mass and radius of TOI2136b is consistent with a broad range of compositions, from water-ice to gas-dominated worlds. TOI-2136b falls close to the radius valley for low-mass stars predicted by the thermally driven atmospheric mass loss models, making it an interesting target for future studies of its interior structure and atmospheric properties., Comment: 19 pages, 15 figures, submitted to MNRAS

Published
2022
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145. Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Author

Wallaeys, Charlotte, Garcia-Gonzalez, Natalia, Timmermans, Steven, Vandewalle, Jolien, Vanderhaeghen, Tineke, De Beul, Somara, Dufoor, Hester, Eggermont, Melanie, Moens, Elise, Bosteels, Victor, De Rycke, Riet, Thery, Fabien, Impens, Francis, Verbanck, Serge, Lienenklaus, Stefan, Janssens, Sophie, Blumberg, Richard S., Iwawaki, Takao, and Libert, Claude

Published
2024
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150. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants

Author

Zhou, Bin, Bennett, James E, Wickham, Aidan P, Singleton, Rosie K, Mishra, Anu, Carrillo-Larco, Rodrigo M, Ikeda, Nayu, Jain, Lakshya, Barradas-Pires, Ana, Heap, Rachel A, Lhoste, Victor PF, Sheffer, Kate E, Phelps, Nowell H, Rayner, Archie W, Gregg, Edward W, Woodward, Mark, Stevens, Gretchen A, Iurilli, Maria LC, Danaei, Goodarz, Di Cesare, Mariachiara, Aguilar-Salinas, Carlos A, Ahmad, Noor Ani, Bovet, Pascal, Chen, Zhengming, Damasceno, Albertino, Filippi, Sarah L, Janszky, Imre, Kengne, Andre P, Khang, Young-Ho, Khunti, Kamlesh, Laxmaiah, Avula, Lim, Lee-Ling, Lissner, Lauren, Margozzini, Paula, Mbanya, Jean Claude N, McGarvey, Stephen T, Shaw, Jonathan E, Söderberg, Stefan, Soto-Mota, Luis Adrián, Wang, Junyang, Zaccardi, Francesco, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Aekplakorn, Wichai, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkhatib, Buthaina M, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amougou, Norbert, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Auvinen, Juha, Avdičová, Mária, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Bacopoulou, Flora, Bahijri, Suhad, Bajramovic, Izet, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Basit, Abdul, Bastos, Joao Luiz, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bettiol, Heloísa, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bhargava, Santosh K, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boggia, Jose G, Bogova, Elena, Bonaccio, Marialaura, Bonilla-Vargas, Alice, Borghs, Herman, Botomba, Steve, Bourne, Rupert, Boymatova, Khadichamo, Braeckman, Lutgart, Braithwaite, Tasanee, Brajkovich, Imperia, Branca, Francesco, Brenner, Hermann, Brewster, Lizzy M, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brug, Johannes, Bugge, Anna, Buntinx, Frank, Buoncristiano, Marta, Burns, Con, Cabrera de León, Antonio, Caixeta, Roberta B, Cama, Tilema, Can, Günay, Cândido, Ana Paula C, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardoso, Viviane C, Carlsson, Axel C, Casanueva, Felipe F, Casas, Maribel, Censi, Laura, Cervantes‐Loaiza, Marvin, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Queenie, Chaturvedi, Nish, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Chong, Chean Lin, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Cohen, Emmanuel, Confortin, Susana C, Coppinger, Tara C, Cortés, Lilia Yadira, Cosmin, Cojocaru R, Costanzo, Simona, Cowan, Melanie J, Cowell, Chris, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Cucu, Alexandra M, Cureau, Felipe V, Cuschieri, Sarah, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva-Ferreira, Haroldo, Dahm, Christina C, Dallongeville, Jean, Dankner, Rachel, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, de Oliveira, Paula Duarte, de Paiva, Karina Mary, De Ridder, Karin, de Valois Correia Júnior, Marco Aurélio, Deepa, Mohan, DeGennaro, Vincent Jr, Demarest, Stefaan, Dennison, Elaine, Deschamps, Valérie, Dhimal, Meghnath, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Donoso, Silvana P, Dorobantu, Maria, Dörr, Marcus, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka L, Dushpanova, Anar, Dyussupova, Azhar, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eghtesad, Sareh, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Elosua, Roberto, Enang, Ofem, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Esmaeili, Ali, Evans, Roger G, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farzadfar, Farshad, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Fernando, Desha R, Ferrante, Daniel, Ferrari, Gerson, Ferrari, Marika, Ferreccio, Catterina, Ferrer, Eldridge, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galfo, Myriam, Garcia-de-la-Hera, Manoli, Garcia, Pablo, Garnett, Sarah P, Gasull, Magda, Gazzinelli, Andrea, Gehring, Ulrike, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Ghimire, Anup, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Goldberg, Marcel, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gonzalez, Angel R, Gottrand, Frederic, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Grodzicki, Tomasz, Grøholt, Else Karin, Grøntved, Anders, Guajardo, Viviana, Guallar-Castillón, Pilar, Guerchet, Maëlenn, Guerrero, Ramiro, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunter, Marc J, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gurzkowska, Beata, Gutierrez, Laura, Gwee, Xinyi, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Heinen, Mirjam, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M, Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hoogendijk, Emiel O, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huidumac Petrescu, Constanta, Huisman, Martijn, Husseini, Abdullatif, Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iakupova, Ellina M, Iannone, Anna G, Igland, Jannicke, Ijoma, Chinwuba, Iotova, Violeta, Irazola, Vilma E, Ishida, Takafumi, Isiguzo, Godsent C, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Ivanova-Pandourska, Ivaila Y, Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T, Jaddou, Hashem Y, Jadoul, Michel, Jafar, Tazeen, Jan, Nataša, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jha, Anjani Kumar, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Juolevi, Anne, Juresa, Vesna, Jureša, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Karki, Khem B, Kassi Anicet, Adoubi, Katibeh, Marzieh, Katulanda, Prasad, Katzmarzyk, Peter T, Kauhanen, Jussi, Kazakbaeva, Gyulli M, Kaze, François F, Ke, Calvin, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kersting, Mathilde, Khader, Yousef Saleh, Khaledifar, Arsalan, Khalili, Davood, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J, Kiechl, Stefan, Kim, Hyeon Chang, Klakk, Heidi, Klanarong, Suntara, Klanova, Jana, Klimek, Magdalena, Knoflach, Michael, Kobel, Susanne, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Koussoh Simone, Malik, Kovács, Éva, Kovalskys, Irina, Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krizan, Helena, Kroker-Lobos, Maria F, Krokstad, Steinar, Kruger, Herculina S, Kruger, Ruan, Kryst, Łukasz, Kubinova, Ruzena, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kulimbet, Mukhtar, Kumari, Meena, Kunešová, Marie, Kurjata, Pawel, Kyobutungi, Catherine, La, Quang Ngoc, Labadarios, Demetre, Lachat, Carl, Lai, Daphne, Laid, Youcef, Lall, Lachmie, Landaeta Jimenez, Maritza, Landais, Edwige, Lankila, Tiina, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Lateva, Mina P, Latt, Tint Swe, Laurenzi, Martino, Lazo-Porras, Maria, Le Coroller, Gwenaëlle, Le Nguyen Bao, Khanh, Lehtimäki, Terho, Lemogoum, Daniel, Leong, Elvynna, Leszczak, Justyna, Leung, Gabriel M, Li, Yanping, Liivak, Merike, Lim, Charlie, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Hsien-Ho, Lind, Lars, Litwin, Mieczyslaw, Liu, Liping, Liu, Xiaotian, Longo Abril, Guadalupe, Lopes, Oscar, Lopez-Garcia, Esther, López-Gil, José Francisco, Lopez, Tania, Lozano, José Eugenio, Lukrafka, Janice L, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lunogelo, Charles, Lustigová, Michala, M'Buyamba-Kabangu, Jean-René, Machado-Coelho, George LL, Machado-Rodrigues, Aristides M, Macia, Enguerran, Madar, Ahmed A, Maestre, Gladys E, Maggi, Stefania, Magliano, Dianna J, Magnacca, Sara, Magriplis, Emmanuella, Mahasampath, Gowri, Maire, Bernard, Makdisse, Marcia, Malekpour, Mohammad-Reza, Malekzadeh, Fatemeh, Malekzadeh, 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2024
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