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We investigate the spatio-temporal characteristics of the austral spring Ross Ice Shelf Polynya (RISP) and its relationship with atmospheric circulation anomalies based on the sea ice concentration data from the National Snow and Ice Data Center (NSIDC) and the ERA5 reanalysis data. The RISP area series is derived by choosing 25% sea ice concentration as the threshold. Then the principal spatial patterns of the RISP are acquired by using the empirical orthogonal function (EOF) analysis. The leading EOF (EOF1) has a spatial distribution of a strong negative core in the northeastern RISP with a weak positive core near the Cape Adare, explaining 48.1% of the variance. This mode matches the wind pattern of the northwesterly on the western Ross Sea while southwesterly on the eastern Ross Sea, which reflects the zonal variation of the RISP. There is also a strong positive correlation between the RISP area and the PC1. The EOF2 explains 27.4% of the variance, and is mainly characterized by a large region of low values in the northwestern Ross Sea with a small region of high value near Cape Colbeck. Matching the strong southerly over the western Ross Sea, the EOF2 partly depicts the meridional variation of the RISP. We further explored the connections between the RISP and sea level pressure, and found that a deeper and more eastward Amundsen Sea Low (ASL) in November often coincides with a larger and more eastward RISP in December. This lagged response is partly generated through the influence of the ASL on the RISP in November.

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Ambient lighting has been identified as a motivationally relevant context that affects cognition, emotion, and behavior, including food consumption and choice. This study adds to this body of work utilizing optimal foraging theory, which predicts individuals will prefer foods that deliver the most energy while costing the least energy to obtain. The environmental contexts in which one will have to forage alter perceived energy expenditure. An experiment was performed in which young adults viewed food advertisements that varied in energy density level in either dim or bright contexts. Metrics assessing motivational activation and attitudes were obtained across and post exposure. Individuals exhibited greater motivational intensity and preference when exposed to more energy dense foods in light contexts, but preference dissipated in dark contexts. Less energy dense foods elicited more motivational preference in dark contexts compared to light. Self-reported attitudes and intentions were only affected by context. Thus, variations in lighting may have larger implications for food choice and overall health.

Prostate cancer (PCa) with prostate-specific membrane antigen (PSMA)-specific high expression is well suited for molecularly targeted theranostics. PSMA expression correlates with the malignancy of PCa, and its dimeric form can promote tumor progression by exerting enzymatic activity to activate downstream signal transduction. However, almost no studies have shown that arresting the procancer signaling of the PSMA receptors themselves can cause tumor cell death. Meanwhile, supramolecular self-assembling peptides are widely used to design anticancer agents due to their unique and excellent properties. Here, a PSMA-targeting supramolecular self-assembling nanotheranostic agent, DBT-2FFGACUPA, which actively targets PSMA receptors on PCa cell membranes and induces them to enter the cell and form large aggregates, is developed. This process not only selectively images PSMA-positive tumor cells but also suppresses the downstream procancer signals of PSMA, causing tumor cell death. This work provides an alternative approach and an advanced agent for molecularly targeted theranostics options in PCa that can induce tumor cell death without relying on any reported anticancer drugs.

Patients with multiple myeloma (MM) who are treated with lenalidomide rarely develop a secondary B-cell acute lymphoblastic leukemia (B-ALL). The clonal and biological relationship between these sequential malignancies is not yet clear. We identified 17 patients with MM treated with lenalidomide, who subsequently developed B-ALL. Patient samples were evaluated through sequencing, cytogenetics/fluorescence in situ hybridization (FISH), immunohistochemical (IHC) staining, and immunoglobulin heavy chain (IgH) clonality assessment. Samples were assessed for shared mutations and recurrently mutated genes. Through whole exome sequencing and cytogenetics/FISH analysis of 7 paired samples (MM vs matched B-ALL), no mutational overlap between samples was observed. Unique dominant IgH clonotypes between the tumors were observed in 5 paired MM/B-ALL samples. Across all 17 B-ALL samples, 14 (83%) had a TP53 variant detected. Three MM samples with sufficient sequencing depth (>500×) revealed rare cells (average of 0.6% variant allele frequency, or 1.2% of cells) with the same TP53 variant identified in the subsequent B-ALL sample. A lack of mutational overlap between MM and B-ALL samples shows that B-ALL developed as a second malignancy arising from a founding population of cells that likely represented unrelated clonal hematopoiesis caused by a TP53 mutation. The recurrent variants in TP53 in the B-ALL samples suggest a common path for malignant transformation that may be similar to that of TP53-mutant, treatment-related acute myeloid leukemia. The presence of rare cells containing TP53 variants in bone marrow at the initiation of lenalidomide treatment suggests that cellular populations containing TP53 variants expand in the presence of lenalidomide to increase the likelihood of B-ALL development.

Sika deer are known to prefer oak leaves, which are rich in tannins and toxic to most mammals; however, the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear. In identifying the mechanism responsible for the tolerance of a highly toxic diet, we have made a major advancement in the elucidation of the genomics of sika deer. We generated the first high-quality, chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments. Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food, especially the expansion of UGT genes in a subfamily. The first chromosome-level assembly and genetic characterization of the tolerance toa highly toxic diet suggest that the sika deer genome will serve as an essential resource for understanding evolutionary events and tannin adaptation. Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.

Introduction Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder and regarded as one of the most frequent genetic causes of infant mortality. The aim of this study is to develop a cost-effectiveness analysis of AVXS-101 (Onasemnogene Abeparvovec/Zolgensma®) and nusinersen (Spinraza®) for SMA to inform decision-making on reimbursement policies in Australia. Methods A Markov model was developed with five health states to evaluate the costs and effects for patients with SMA Type I from a healthcare system perspective over a time-horizon of 100 years. The model parameters were based on clinical trials, parametric distributions, published literature, and Australian registries. One-way and probabilistic sensitivity analysis were performed to appraise the uncertainties of the parameters in the model. A threshold analysis was conducted to estimate the cost of AVXS-101 of being cost-effective. Results The incremental cost-effectiveness ratio (ICER) of AVXS-101 was $1,808,471 per quality-adjusted life year (QALY) and that of nusinersen was $2,772,798 per QALY, compared to standard of care, respectively. The ICER of AVXS-101 was $1,238,288 per QALY compared to nusinersen. The key drivers influencing on ICERs were costs of using treatments and utility values of sitting and walking independently. Conclusion Both nusinersen and AVXS-101 resulted in health benefits, but they were not cost-effective with a commonly used willingness-to-pay (WTP) threshold of $50,000 per QALY. Developing high-quality clinical data and exploring appropriate WTP thresholds are critical for decision-making on reimbursement policies in the treatment of rare diseases.

Triple negative breast cancer (TNBC) is an immunosuppressive "cold" tumor that lacks immune cell infiltration and activation, resulting in a poor response to immune checkpoint blockade (ICB) therapies. In addition, TNBC is poorly responsive to targeted therapies due to the absence of efficient molecular targets. A strategy that can block molecular signal transduction, stimulate immunogenicity, and activate the immune response is a promising approach to achieve ideal clinical benefit. Herein, we designed and synthesized an aggregation-induced emission luminogen (AIEgen)-conjugated self-assembling peptide that targets epidermal growth factor receptor (EGFR), named TPA-FFG-LA. TPA-FFG-LA peptides form nanoassemblies on the surface of EGFR-positive TNBC cells and are internalized into cells through endocytosis, which inhibit EGFR signaling transduction and provoke lysosomal membrane permeabilization (LMP). Upon light irradiation, the aggregated AIEgens produce massive reactive oxygen species (ROS) to exacerbate LMP and trigger immunogenic cell death (ICD), resulting in elimination of residual EGFR-negative tumor cells and exerting long-term antitumor effects. The in vitro and in vivo experiments verified that TPA-FFG-LA nanoassemblies suppress tumor growth, provoke immune cell activation and infiltration, and cause EGFR degradation and LMP. These results suggest that the combination of supramolecular assembly induced molecular targeting effects and lysosome dysfunction with ICD-stimulated immune activation is a plausible strategy for the efficient therapy of immunosuppressive TNBC.

Quasi-one-dimensional van der Waals (vdW) materials are a promising system for future applications in electronics and optoelectronics. Here we report systematic studies on the electronic and optoel...

Interpersonal rejection has been found to impair people’s prosocial actions. However, this relation may change as a function of theoretically relevant personality traits. The present study examined the potential moderating roles of trait mindfulness in the longitudinal relations between peer rejection and prosocial behaviors. At two time points with an interval of eight months, 654 adolescents nominated children in their class who have been rejected by peers and children who have enacted prosocial behaviors toward classmates and then completed the mindfulness questionnaire. Cross-lagged model results indicated that peer rejection could negatively predict prosocial behaviors in both high and low mindfulness groups of children while the reverse predictive relation from prosociality to peer rejection was not significant. More prominent, trait mindfulness might buffer the negative contribution of peer rejection to prosocial behaviors. Within a more ecologically valid context with a longitudinal design, our study contributed to a better understanding of the conditions under which interpersonal rejection may undermine prosocial behaviors.

Electrically responsive electrochemical actuators that contain a polymer electrolyte membrane laminated between two electrodes have attracted great attention due to their potential applications in smart electronics, wearable devices, and soft robotics. However, some challenges such as the achievement of large bending strain under low applied voltage and fast ion diffusion and accumulation still exist to be resolved. The key to the solution lies in the choice of electrode materials and the design of electrode structures. In this study, an engineering electrochemical actuator that presents large bending strain under low applied voltage based on MXene/polystyrene-MXene hybrid electrodes is developed. The developed electrochemical actuator based on the MXene/polystyrene-MXene 3D-structure is found to exhibit large bending strain (ca. 1.18%), broad frequency bandwidth, good durability (90% retention after 10,000 cycles) and considerable Young’s modulus (ca. 246 MPa). The high-performance actuation mainly stems from the excellent properties of MXene and 3D-structure of the electrode. The MXene provides excellent mechanical strength and high electrical conductivity which facilitate strong interaction and rapid electron transfer in electrodes. The 3D architectures formed by polystyrene microspheres generate unimpeded ion pathways for ionic short diffusion and fast injection. This study reveals that the 3D-structure hybrid electrodes play a crucial role in promoting the performance of such electrochemical actuators.

Shape memory polymers (SMPs) that change shapes as designed by external stimuli have become one of the most promising materials as actuators, sensors, and deployable devices. However, their practical applications have been greatly limited due to the long recovery time, which mainly originates from their low recovery stress, inherent viscoelastic hysteresis effect and low heat transmission efficiency. In this work, a novel method is proposed to prepare fast responsive reduced graphene oxide/shape memory polyurethane/polyurethane foam (rGO/SMPU/PU foam) shape memory composites. The elastic PU foam is used as framework to be coated with SMPU and rGO by solution polymerization and self-assembly methods, which result in rGO/SMPU/PU foam with three-dimensional networks. The rGO/SMPU/PU foam exhibits a fast response (of less than 1 s) under a large compressing deformation (80%) due to the synergistic effect of the high elasticity of PU foam, the short energy transmission distance of the SMPU layer and the high thermal conductivity of the rGO layer. Moreover, owing to the outstanding shape fixity ratio (Rf) and shape recovery ratio (Rr) of SMPU and the mechanical properties of PU foam, the rGO/SMPU/PU foam shows an excellent shape memory effect (more than 98% Rf and Rr at 80% strain) and cyclic stability simultaneously. Such rGO/SMPU/PU foam material demonstrates the potential applications in high-sensitivity temperature sensors and temperature codes.

We aimed to clarify the relationship between Chinese adolescents’ physical activity and academic achievement, the mediating role of physical and mental health, and provide a scientific reference for the integration of sports and education. Based on baseline data from the China Education Panel Survey, we conducted a nationwide study of 12,960 adolescents. We used nonlinear models, mediation effect analysis, and other measurement methods. Three significant findings emerged: (1) adolescent physical activity duration and academic achievement showed an inverted U-shaped relationship. Moderate physical activity improves academic achievement. The inverted U-shaped inflection point is about 3.549 h/week; (2) physical activity among the male group has a stronger effect on promoting academic achievement, while the positive effect of physical activity among females is not significant. The difference in effectiveness between urban and rural youth groups is relatively small, but the inflection point of rural youth groups is higher, and (3) the level of physical and mental health effectively mediates the inverted U-shaped influence of youth physical activity on academic achievement. We recommend that governments and schools should implement physical activity appropriately and suggest the feasibility of using physical activity to narrow the growth gap between urban and rural youth.

Two-dimensional (2D) transition metal dichalcogenide (TMDC) materials have garnered great attention on account of their novel properties and potential to advance modern technology. Recent studies have demonstrated that TMDCs can be utilized to create high-performing heterostructures with combined functionality of the individual layers and new phenomena at these interfaces. Here, we report an ultrafast photoresponse within MoSe2-based heterostructures in which heavily p-doped WSe2 and MoS2 flakes share an undoped MoSe2 channel, allowing us to directly compare the optoelectronic properties of MoSe2-based heterojunctions with different 2D materials. Strong photocurrent signals have been observed in both MoSe2-WSe2 and MoSe2-MoS2 heterojunctions with a photoresponse time constant of ∼16 μs, surmounting previous MoSe2-based devices by three orders of magnitude. Further studies have shown that the fast response is independent of the integrated 2D materials (WSe2 or MoS2) but is likely attributed to the high carrier mobility of 260 cm2 V-1 s-1 in the undoped MoSe2 channel as well as the greatly reduced Schottky barriers and near absence of interface states at MoSe2-WSe2/MoS2 heterojunctions, which lead to reduced carrier transit time and thus short photocurrent response time. Lastly, a high detectivity on the order of ∼1014 Jones has been achieved in MoSe2-based heterojunctions, which supersedes current industry standards. These fundamental studies not only shed light on photocurrent generation mechanisms in MoSe2-based heterojunctions but also open up new avenues for engineering future high-performance 2D optoelectronic devices.

Linear polyimides of intrinsic microporosity have been intensively investigated for gas separation due to their microporous structure and high surface area. The microporous structure in the linear polyimides of intrinsic microporosity comes from their contorted structure. Therefore, most linear polyimides without contorted structure do not have micropores. In this work, the microporous polyimides are constructed through the condensation of a cross-linkable dianhydride monomer with two novel nitrogen-rich diamine monomers and post crosslinking reaction. The linear polyimide precursors without contorted structure have the same main-chain structure. The introduction of crosslinked structure endow the crosslinked polyimides (PI-CLs) with microporous structure. The microporous structure in PI-CLs can be tuned by changing the substituents of the linear polyimide precursors. The PI-CLs have competitive CO2 uptake capacity (7.3–9.4 wt%) at 273 K and 1 bar. Particularly, the crosslinked polyimide containing trifluoromethyl groups (CF3-PI-CL) shows high CO2/N2 and CO2/CH4 selectivity (72 and 22) at 273 K, which are among the best results for reported porous materials. This work reveals that the introduction of crosslinked structure and changing substituents is an efficient method for constructing microporous polyimides with abundant micropores and excellent CO2 selective adsorption capacity. This method also has great potential for fabricating high-performance microporous polymers based on other linear polymers without rigid contorted structure.

High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that plays essential roles in embryonic development and cancer progression. However, the mechanism of HMGA2 regulation remains largely uncharacterized. Here, we demonstrate that HMGA2 can be modulated by hepatitis B X-interacting protein (HBXIP), an oncogenic transcriptional coactivator, in esophageal squamous cell carcinoma (ESCC). HMGA2 expression was positively associated with HBXIP expression in clinical ESCC tissues, and their high levels were associated with advanced tumor stage and reduced overall and disease-free survival. We found that oncogenic HBXIP could posttranslationally upregulate HMGA2 protein level in ESCC cells. HBXIP induced HMGA2 acetylation at the lysine 26 (K26), resulting in HMGA2 protein accumulation. In this process, HBXIP increased the acetyltransferase p300/CBP-associated factor (PCAF) phosphorylation and activation via the Akt pathway, then PCAF directly interacted with HMGA2, leading to HMGA2 acetylation in the cells. HMGA2 K26 acetylation enhanced its DNA binding capacity and blocked its ubiquitination and then inhibited proteasome-dependent degradation. Functionally, HBXIP-stabilized HMGA2 could promote ESCC cell growth in vitro and in vivo. Strikingly, aspirin suppressed ESCC growth by inhibiting HBXIP and HMGA2. Collectively, our findings disclose a new mechanism for the posttranslational regulation of HMGA2 mediated by HBXIP in ESCC.

In lost foam casting (LFC), the presence of an expanded polystyrene (EPS) inside the mold leads to new features for the filling of the melt. The burning of the EPS pattern has great effect on its filling. To provide benchmark experiments for the modeling and numerical simulation of the mold filling process for LFC, a vertical plate with a window was selected. The window was designed in variation of sizes and distances to the borders so as to investigate the melt filling of a series of narrow paths in LFC. The designed EPS pattern were made and the corresponding molds were prepared and melt cast iron was poured. The measurement system of liquid metal filling based on modified contact time method (METM) was used. The filling of measured points was illustrated by an array of light-emitting diodes (LED) arranged resembling the shape of the casting, with the lightening of each diode representing the filling time instant of the measurement point. The filling times of all the points were obtained by the image analysis of recorded movie. The filling profiles and filling velocity during filling process were obtained. The filling results provide support for numerical simulation of LFC. Keywords: Lost foam casting (LFC), mold filling, modified contact time method, LED display, plate casting, cast iron

Polyimides with intrinsic microporosity have been well developed and explored in the field of gas adsorption and separation. However, most linear polyimides without rigid and distorted segments do ...

Porphyrin units are a kind of ideal electron donor units, which have large π conjugation and well-defined planar and electron-rich structures. The inserted alkynyl π bridges between porphyrin units...

This study investigated the removal efficiencies of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and chlorobenzenes (CBzs) by different air pollution control devices (APCDs) in three municipal solid waste incinerators (MSWIs). These devices were the semi-dry flue gas desulfurization (SDFGD) system, activated carbon (AC) injector, bag filters (BF), selective catalytic reduction (SCR) reactor, and wet scrubber. The SDFGD system, AC injector, and BF exhibited similar removal efficiencies for all of the pollutants. Overall, the removal efficiency of CBzs was also considerably lower than the PCDD/Fs. The less chlorinated CBzs were also less likely to be adsorbed by AC and BF and more likely to be decomposed by the SCR reactor. Additionally, the “memory effect” in the wet scrubbers elevated the concentrations of the PCDD/Fs and even the CBzs in the flue gas, with the highest increases observed for penta- to hepta-chlorinated PCDD/Fs and TrCBzs. Given the different effects of these various devices, especially the wet scrubber, the correlation between PCDD/F and CBz removal should be individually assessed for each APCD unit. More accurate indicators of PCDD/F removal are also examined.

Given the serious work hardening phenomenon, high chemical activity, severe tool wear, and poor workpiece surface quality during the cutting of titanium alloys, placing micro-texture on the tool surface decreases the tool-chip contact area and friction and plays the role of wear resistance and friction reduction. In order to improve the cutting performance of cutting tools, the present study examins the effect of micro-texture parameters of a cemented carbide ball-end milling cutter on cutting force, tool wear, and workpiece surface roughness and establishes a regression analysis model via regression analysis. We consider the cutting performance of a cemented carbide micro-texture ball-end milling cutter as an evaluation standard. A genetic algorithm is applied to the multi-objective optimization of micro-texture parameters, and a regression analysis model of micro-texture design criteria is established. This provides a standardised reference to select standard micro-texture parameters in the design and preparation of a cemented carbide micro-texture ball-end milling cutter.

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In practice, a variety of composite indicators are created using the arithmetic average of different sub-indicators. However, this scheme is typically criticized of the possibility of compensation. For this reason, this paper re-constructs these composite indicators by means of a new methodology. Comprehensive individual judgements among the sub-indicators have been considered to determine the maximum total utilities. Then the best–worst method is introduced to determine the preference associated with various individual judgements. An illustration of Value Measure of health systems is presented to demonstrate the validity and usefulness of our methodology.

Titanium alloys is a typical difficult-to-cut material with many machining problems, build-up-edge, large cutting force, and high cutting heat. Previous research has shown that micro-texture on the tool surface can solve the above problems potentially, and that a blunt round edge of the cutting tool can enhance its strength and improve the tool wear resistance. Therefore, towards an optimal parameter of micro-texture and blunt round radius, a finite element method (FEM) simulation and an experiment are carried out, where the test result provides a set of data for a genetic algorithm–based prediction model. The optimized parameter combinations of the micro-textured ball-end milling cutter with a blunt round edge are obtained and compared in a set of experiments. The optimized parameters refer to a 40-μm radius of the blunt round edge, a 40-μm micro-texture diameter, a 175-μm spacing, a 120-μm distance from the cutting edge, and an 80-μm depth.

Interfacial phenomena and heat transfer associated with single droplet impact on a flowing liquid film are studied with three-dimensional simulations. Shear-induced sheet-film contact is detected s...

Lay abstract To date, the morbidity and mortality of clear cell renal cell carcinoma (ccRCC) are gradually increasing, and ccRCC is more aggressive than other kidney cancer types. The

The effects of biological factors on the vegetative growth process of mushrooms remain largely unexplored. We investigated the bacterial community in different growth stages of

Droplet impinging on the boundary between hydrophilic and hydrophobic regions of a hybrid-wettability surface is studied both experimentally and numerically in the present paper. The interfacial evolution and dynamic feature and the corresponding underlying mechanisms behind are mainly analyzed. Because of the unbalanced surface energy in the vicinity of a boundary, the droplet undergoes spreading-receding in the hydrophobic region before migration toward the hydrophilic region. This results in an increase first but then a decrease in the spreading factor in the hydrophobic region, while it increases continuously in the hydrophilic region. In addition, increasing Weber number leads to the increase in both the spreading factor and migration displacement of the droplet in the hydrophobic region, but the latter decreases in the hydrophilic region, resulting from different momentums of secondary spreading. The experimental determinations are verified in detail by a series of numerical simulations performed based on the single variable method by fixing contact angles in different regions separately and excluding the impact momentum. It is shown that the highly unsymmetrical pressure field is exactly one important reason for droplet migration on the hybrid-wettability surface. Despite the weak dependence of the spreading factor on the hydrophilic contact angle in the hydrophobic region, it has an appreciably positive effect on droplet migration, which is confirmed by the increased pressure gradient with its action area in the hydrophobic region when decreasing the hydrophilic contact angle. This paper advances the fundamental understanding for droplet migration on the hybrid-/gradient-wettability surface.

Myeloproliferative neoplasms (MPNs) are associated with significant alterations in the bone marrow microenvironment that include decreased expression of key niche factors and myelofibrosis. Here, we explored the contribution of TGF-β to these alterations by abrogating TGF-β signaling in bone marrow mesenchymal stromal cells. Loss of TGF-β signaling in Osx-Cre-targeted MSCs prevented the development of myelofibrosis in both MPLW515L and Jak2V617F models of MPNs. In contrast, despite the absence of myelofibrosis, loss of TGF-β signaling in mesenchymal stromal cells did not rescue the defective hematopoietic niche induced by MPLW515L, as evidenced by decreased bone marrow cellularity, hematopoietic stem/progenitor cell number, and Cxcl12 and Kitlg expression, and the presence of splenic extramedullary hematopoiesis. Induction of myelofibrosis by MPLW515L was intact in Osx-Cre Smad4fl/fl recipients, demonstrating that SMAD4-independent TGF-β signaling mediates the myelofibrosis phenotype. Indeed, treatment with a c-Jun N-terminal kinase (JNK) inhibitor prevented the development of myelofibrosis induced by MPLW515L. Together, these data show that JNK-dependent TGF-β signaling in mesenchymal stromal cells is responsible for the development of myelofibrosis but not hematopoietic niche disruption in MPNs, suggesting that the signals that regulate niche gene expression in bone marrow mesenchymal stromal cells are distinct from those that induce a fibrogenic program.

Forkhead box D1 (FOXD1) is a new member of FOX transcription factor family. FOXD1 has demonstrated multilevel roles during normal development, and several diseases’ pathogenesis. However, little is known about the role of FOXD1 in the progression of head and neck squamous cancer (HNSC). In the present study, we analyzed FOXD1 expression pattern using The Cancer Genome Atlas (TCGA) dataset, Gene Expression Omnibus (GEO) datasets, HNSC cell lines, and HNSC tissues. Then, we analyzed the correlation between FOXD1 expression and clinical characteristics, and evaluated the prognostic value of FOXD1 in HNSC. Moreover, we assessed the relationship between FOXD1 expression and tumor microenvironment (TME) and immune cell infiltration using Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) and Cell-type Identification By Estimating Relative Subsets Of known RNA Transcripts (CIBERSORT) algorithms. Finally, we predicted the FOXD1-related biological processes (BPs) and signal pathways. FOXD1 was up-regulated in HNSC tissues in TCGA datasets, validated by GEO datasets, HNSC cell lines and HNSC tissues. FOXD1 expression was significantly associated with tumor site and HPV infection. Univariate and multivariate Cox regression analyses showed that FOXD1 expression was an independent prognostic factor. Moreover, we found that the proportions of naïve B cells, plasma cells, and resting dendritic cells (DCs) were negatively correlated with FOXD1 expression, otherwise, the proportion of activated mast cells was positively correlated with FOXD1 expression using CIBERSORT algorithm. Gene Set Enrichment Analyses (GSEAs) revealed that FOXD1 was mainly involved in cancer-related signaling pathway and metabolism-related pathways. FOXD1 was a potential oncogene, and might represent an indicator for predicting overall survival (OS) of HNSC patients. Moreover, many cancer-related pathways and metabolism-related processes may be regulated by FOXD1.